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Association of Body Composition Changes with the Development of Diabetes Mellitus: A Nation-Wide Population Study
Hyung Jun Kim, Hyung-Woo Lee, Min-Kyoung Kang, Gwang Hyun Leem, Min-Ho Kim, Tae-Jin Song
Diabetes Metab J. 2024;48(6):1093-1104.   Published online May 21, 2024
DOI: https://doi.org/10.4093/dmj.2023.0243
  • 1,859 View
  • 109 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
We investigated the association between body composition changes and new-onset diabetes mellitus (DM) development according to the body mass index (BMI) in a longitudinal setting in the general Korean population.
Methods
From 2010 to 2011 (1st) and 2012 to 2013 (2nd), we included 1,607,508 stratified random sample participants without DM from the National Health Insurance Service-Health Screening dataset of Korean. The predicted appendicular skeletal muscle mass index (pASMMI), body fat mass index (pBFMI), and lean body mass index (pLBMI) were calculated using pre-validated anthropometric prediction equations. A prediction equation was constructed by combining age, weight, height, waist circumference, serum creatinine levels, alcohol consumption status, physical activity, and smoking history as variables affecting body composition.
Results
Decreased pASMMI (men: hazard ratio [HR], 0.866; 95% confidence interval [CI], 0.830 to 0.903; P<0.001; women: HR, 0.748; 95% CI, 0.635 to 0.881; P<0.001), decreased pLBMI (men: HR, 0.931; 95% CI, 0.912 to 0.952; P<0.001; women: HR, 0.906; 95% CI, 0.856 to 0.959; P=0.007), and increased pBFMI (men: HR, 1.073; 95% CI, 1.050 to 1.096; P<0.001; women: HR, 1.114; 95% CI, 1.047 to 1.186; P=0.007) correlated with the development of new-onset DM. Notably, only in the overweight and obese BMI categories, decreases in pASMMI and pLBMI and increases in pBFMI associated with new-onset DM, regardless of gender.
Conclusion
Decreased pASMMI and pLBMI, and increased pBFMI with excess fat accumulation may enhance the risk of newonset DM. Therefore, appropriate changes in body composition can help prevent new-onset DM.
Epidemiology
Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Yeonju La, Da Eun Kwon, Sang Hoon Han
Diabetes Metab J. 2019;43(6):815-829.   Published online January 21, 2019
DOI: https://doi.org/10.4093/dmj.2018.0167
  • 5,962 View
  • 83 Download
  • 20 Web of Science
  • 19 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM).

Methods

From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 million, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Diseases and Related-Health Problems 10th Revision (ICD-10) B25 code between 2010 and 2014 after exclusion of patients with T2DM to 2006. The 2,880 control patients without T2DM from 2006 to cohort entry point were selected between 2010 and 2014 by age, sex matching with case group. The subjects without new-onset T2DM were followed until 2015. T2DM, hypertension (HTN), dyslipidemia (DYS), and end-stage renal disease (ESRD) were coded as ICD-10.

Results

The frequency of new-onset T2DM in case group was significantly higher than that in control (5.6% vs. 2.2%, P<0.001). The group with T2DM (n=95) had higher incidence of CMV diseases than the group without T2DM (n=3,361) (33.7% vs. 16.2%, P<0.001). In multivariate regression model adjusted by age, sex, lower income, HTN, and DYS, the incidence rate (IR) of T2DM in case group was significantly higher than that in the control group (IR per 1,000, 19.0 vs. 7.3; odds ratio, 2.1; 95% confidence interval, 1.3 to 3.2). The co-existence of HTN, DYS, and ESRD with CMV diseases did not influence the IR of T2DM.

Conclusion

CMV diseases increase the patients' risk of developing T2DM.

Citations

Citations to this article as recorded by  
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    Viruses.2021; 13(11): 2245.     CrossRef
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Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System
Sun Ok Song, Chang Hee Jung, Young Duk Song, Cheol-Young Park, Hyuk-Sang Kwon, Bong Soo Cha, Joong-Yeol Park, Ki-Up Lee, Kyung Soo Ko, Byung-Wan Lee
Diabetes Metab J. 2014;38(5):395-403.   Published online October 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.5.395
  • 11,575 View
  • 134 Download
  • 507 Web of Science
  • 510 Crossref
AbstractAbstract PDFPubReader   
Background

The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access to the databases within the Korean Diabetes Association for the benefit of Korean subjects with diabetes. Here, we present the history, structure, contents, and way to use data procurement in the Korean National Health Insurance (NHI) system for the benefit of Korean researchers.

Methods

The NHIS in Korea is a single-payer program and is mandatory for all residents in Korea. The three main healthcare programs of the NHI, Medical Aid, and long-term care insurance (LTCI) provide 100% coverage for the Korean population. The NHIS in Korea has adopted a fee-for-service system to pay health providers. Researchers can obtain health information from the four databases of the insured that contain data on health insurance claims, health check-ups and LTCI.

Results

Metabolic disease as chronic disease is increasing with aging society. NHIS data is based on mandatory, serial population data, so, this might show the time course of disease and predict some disease progress, and also be used in primary and secondary prevention of disease after data mining.

Conclusion

The NHIS database represents the entire Korean population and can be used as a population-based database. The integrated information technology of the NHIS database makes it a world-leading population-based epidemiology and disease research platform.

Citations

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    Inha Jung, Da Young Lee, Seung Min Chung, So Young Park, Ji Hee Yu, Jun Sung Moon, Ji A Seo, Kyungdo Han, Nan Hee Kim
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    European Archives of Oto-Rhino-Laryngology.2023; 280(5): 2181.     CrossRef
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    Hee‐Kyung Joh, Hyuktae Kwon, Ki Young Son, Jae Moon Yun, Su Hwan Cho, Kyungdo Han, Jin‐Ho Park, Belong Cho
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    European Journal of Internal Medicine.2023; 107: 66.     CrossRef
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    Byungyoon Yun, Juyeon Oh, Sang Hoon Ahn, Jin-Ha Yoon, Beom Kyung Kim
    American Journal of Gastroenterology.2023; 118(6): 1001.     CrossRef
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    Jung Eun Yoo, Kyungdo Han, Jin‐Hyung Jung, Yang‐Im Hur, Yang Hyun Kim, Eun Sook Kim, Jang Won Son, Eun‐Jung Rhee, Won‐Young Lee, Ga Eun Nam
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 369.     CrossRef
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    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 585.     CrossRef
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    Yoonjeong Choi, Young-Eun Kim, Ja-Ho Leigh, Ye Seol Lee, Han-Kyoul Kim, You Gyoung Yi, Jinyoung Lee, Min-Yong Lee, Gangpyo Lee, Hyung-Ik Shin, Moon Suk Bang
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    International Journal of Drug Policy.2023; 112: 103953.     CrossRef
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    Journal of Integrative Medicine.2023; 21(2): 176.     CrossRef
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    Graefe's Archive for Clinical and Experimental Ophthalmology.2023;[Epub]     CrossRef
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    Hyein Han, Du Hyun Ro, Sungho Won, Hyuk-Soo Han
    The Journal of Arthroplasty.2023; 38(8): 1470.     CrossRef
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    IEEE Access.2023; 11: 17983.     CrossRef
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    Daniel Duck-Jin Hwang, Kyung-Eun Lee, Yuwon Kim, Myoung-Suk Kim, Tyler Hyungtaek Rim, Mina Kim, Hasung Kim, Dae-Sung Kyoung, Ji In Park
    JAMA Network Open.2023; 6(3): e233068.     CrossRef
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    Dojoon Park, Yong-Moon Park, Seung-Hyun Ko, Kang-Se Hyun, Youn-Ho Choi, Dong-Uk Min, Kyungdo Han, Hae-Seok Koh
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    Bokyung Kim, Jin-Hyung Jung, Kyungdo Han, Seungkyung Kang, Eunwoo Lee, Hyunsoo Chung, Sang Gyun Kim, Soo-Jeong Cho
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    Mi Hee Cho, Kyungdo Han, Seungwoo Lee, Su-Min Jeong, Jung Eun Yoo, SangYun Kim, Jinkook Lee, Sohyun Chun, Dong Wook Shin
    Alzheimer's Research & Therapy.2023;[Epub]     CrossRef
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    Sanghyun Oh, Jihwan Lee, Yoo S Hong, Kyuwoong Kim
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    Juncheol Lee, Yongil Cho, Jaehoon Oh, Hyunggoo Kang, Tae Ho Lim, Byuk Sung Ko, Kyung Hun Yoo, Sang Hwan Lee
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    Journal of Clinical Medicine.2023; 12(8): 2860.     CrossRef
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  • The Association between Metabolic Syndrome and Epithelial Cell Abnormalities Detected on Pap Smear: A Nationwide Population-Based Study
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    Eun‐Saem Choi, Young Mi Jung, Kyu‐Dong Cho, Sungyeon Ha, Jeongwon Sohn, Su Jung Hong, Min‐Jeong Oh, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
    BJOG: An International Journal of Obstetrics & Gynaecology.2023; 130(11): 1370.     CrossRef
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    Journal of Crohn's and Colitis.2023; 17(5): 681.     CrossRef
  • Lifestyle factors and long-term survival in patients with chronic non-cancer pain: a nationwide cohort study in South Korea
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    Journal of Anesthesia.2023; 37(4): 522.     CrossRef
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    Woo Hyun Paik, Dong Kee Jang, Soyoung Cho, Jin Ho Choi, Min Kyu Kim, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Kyung-Do Han, Sang Hyub Lee
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  • Association between regular physical activity and lower incidence of colorectal cancer in patients with diabetes mellitus: a nationwide cohort study
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    Hong Rae Kim, Jino Park, Sung Jun Park, Ho Jin Kim, Seonok Kim, Ye-Jee Kim, Jung-Min Ahn, Dae-Hee Kim, Joon Bum Kim
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    Diabetes Research and Clinical Practice.2023; 202: 110819.     CrossRef
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    SuYeon Kwon, Seungwoo Cha, Junsik Kim, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim, Sina Azadnajafabad
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    European Journal of Endocrinology.2023; 189(2): 225.     CrossRef
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    PLOS ONE.2023; 18(10): e0292362.     CrossRef
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    Psychiatry Investigation.2023; 20(9): 834.     CrossRef
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    Journal of Psychiatric Research.2023; 167: 93.     CrossRef
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    Psychiatry Research.2023; 330: 115613.     CrossRef
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    European Journal of Clinical Pharmacology.2023; 79(12): 1699.     CrossRef
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    Journal of the American Heart Association.2023;[Epub]     CrossRef
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    Journal of Clinical Medicine.2023; 13(1): 92.     CrossRef
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    Nutrients.2023; 15(24): 5040.     CrossRef
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    Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
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    Journal of Korean Neurosurgical Society.2023;[Epub]     CrossRef
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    So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
    Cardiovascular Drugs and Therapy.2022; 36(4): 679.     CrossRef
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    Asian Journal of Surgery.2022; 45(1): 189.     CrossRef
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    Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906.     CrossRef
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    The Korean Journal of Internal Medicine.2022; 37(6): 1250.     CrossRef
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    Hypertension.2022; 79(1): 218.     CrossRef
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    Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
    Neurological Sciences.2022; 43(5): 3395.     CrossRef
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    Journal of Chemotherapy.2022; 34(8): 534.     CrossRef
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    Bum Sik Tae, Young Eun Yoon, Woong Na, Kyung Jin Oh, Sung Yul Park, Jae Young Park, Hong Sang Moon
    Investigative and Clinical Urology.2022; 63(1): 92.     CrossRef
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    Korean Circulation Journal.2022; 52(2): 136.     CrossRef
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    BMC Pulmonary Medicine.2022;[Epub]     CrossRef
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    Journal of Neurotrauma.2022; 39(5-6): 390.     CrossRef
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    Biomedicines.2022; 10(2): 303.     CrossRef
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    Clinical Nutrition Research.2022; 11(1): 32.     CrossRef
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    Resuscitation.2022; 173: 31.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    JAMA Network Open.2022; 5(2): e220262.     CrossRef
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    Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
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    Diagnostics.2022; 12(3): 663.     CrossRef
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    Journal of Psychiatric Research.2022; 149: 226.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    The Breast.2022; 63: 46.     CrossRef
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    Journal of Bone and Mineral Metabolism.2022; 40(4): 602.     CrossRef
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    Archives of Orthopaedic and Trauma Surgery.2022; 143(5): 2307.     CrossRef
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    PLOS ONE.2022; 17(4): e0266262.     CrossRef
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    Cancer Research and Treatment.2022; 54(2): 572.     CrossRef
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    International Journal of Environmental Research and Public Health.2022; 19(9): 4949.     CrossRef
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    Nutrients.2022; 14(8): 1644.     CrossRef
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    Journal of Personalized Medicine.2022; 12(5): 691.     CrossRef
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    Frontiers in Neurology.2022;[Epub]     CrossRef
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    Cancers.2022; 14(11): 2604.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Hepatology Communications.2022; 6(9): 2455.     CrossRef
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    Yonsei Medical Journal.2022; 63(8): 774.     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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    Scientific Reports.2022;[Epub]     CrossRef
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  • Association of Hypertension With the Risk and Severity of Epistaxis
    Hayoung Byun, Jae Ho Chung, Seung Hwan Lee, Jiin Ryu, Changsun Kim, Jeong-Hun Shin
    JAMA Otolaryngology–Head & Neck Surgery.2021; 147(1): 34.     CrossRef
  • The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
    Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur
    Bone.2021; 142: 115691.     CrossRef
  • Increased atrial fibrillation risk in Parkinson’s disease: A nationwide population‐based study
    Seokmoon Han, Inki Moon, Eue‐Keun Choi, Kyung‐Do Han, Hae‐Chan Cho, Seo‐Young Lee, Seokhun Yang, Soonil Kwon, You‐jung Choi, Hyun‐Jung Lee, Euijae Lee, So‐Ryung Lee, Seil Oh
    Annals of Clinical and Translational Neurology.2021; 8(1): 238.     CrossRef
  • Risk of Cancer Following the Use of N-Nitrosodimethylamine (NDMA) Contaminated Ranitidine Products: A Nationwide Cohort Study in South Korea
    Hong Jin Yoon, Jie-Hyun Kim, Gi Hyeon Seo, Hyojin Park
    Journal of Clinical Medicine.2021; 10(1): 153.     CrossRef
  • The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
    Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Alzheimer's Research & Therapy.2021;[Epub]     CrossRef
  • Ten-Year Relative Survival From the Diagnosis of Parkinson's Disease: A Nationwide Database Study
    Han Gil Seo, Seong Jun Byun, Byung-Mo Oh, Sang Jun Park
    Journal of the American Medical Directors Association.2021; 22(8): 1757.     CrossRef
  • Short- and long-term exposure to air pollution and lack of sunlight are associated with an increased risk of depression: A nested case-control study using meteorological data and national sample cohort data
    So Young Kim, Minji Bang, Jee Hye Wee, Chanyang Min, Dae Myoung Yoo, Sang-Min Han, Seungdo Kim, Hyo Geun Choi
    Science of The Total Environment.2021; 757: 143960.     CrossRef
  • Associations between metabolic syndrome and type of dementia: analysis based on the National Health Insurance Service database of Gangwon province in South Korea
    Yeo Jin Kim, Sang Mi Kim, Dae Hyun Jeong, Sang-Kyu Lee, Moo-Eob Ahn, Ohk-Hyun Ryu
    Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
  • Repeatedly elevated γ-glutamyltransferase levels are associated with an increased incidence of digestive cancers: A population-based cohort study
    Chang-Hoon Lee, Kyungdo Han, Da Hye Kim, Min-Sun Kwak
    World Journal of Gastroenterology.2021; 27(2): 176.     CrossRef
  • Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: A nationwide population-based study
    Min Kyung Chung, Jin Su Park, Hyunsun Lim, Chan Hee Lee, Jisoo Lee
    Lupus.2021; 30(4): 674.     CrossRef
  • Effect of institutional case volume on mid-term mortality after coronary artery bypass grafting surgery
    Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongyeon Jang, Bo Rim Kim, Ho Geol Ryu
    General Thoracic and Cardiovascular Surgery.2021; 69(9): 1275.     CrossRef
  • Rheumatoid arthritis in low‐level toluene‐exposed workers based on nationwide medical surveillance data in Korea
    Young‐Sun Min, Sungho Lee, Mingi Kim, Yeon‐Soon Ahn
    American Journal of Industrial Medicine.2021; 64(4): 245.     CrossRef
  • Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
    Seong-Su Moon, Chong Hwa Kim, Seon Mee Kang, Eun Sook Kim, Tae Jung Oh, Jae-Seung Yun, Ho Chan Cho, Dae Jung Kim, Tae Sun Park
    Diabetes & Metabolism Journal.2021; 45(1): 115.     CrossRef
  • Risk factors associated with failure of total ankle arthroplasty: a nationwide cohort study
    Dong Hun Suh, Kyungdo Han, Jin Woo Lee, Hak Jun Kim, Bongsung Kim, Bong Mo Koo, Hak Kyu Kim, Gi Won Choi
    Scientific Reports.2021;[Epub]     CrossRef
  • Impact of body mass index on development of nontuberculous mycobacterial pulmonary disease
    Jin Hwa Song, Bong Seong Kim, Nakwon Kwak, Kyungdo Han, Jae-Joon Yim
    European Respiratory Journal.2021; 57(2): 2000454.     CrossRef
  • Survival in untreated hepatocellular carcinoma: A national cohort study
    Young Ae Kim, Danbee Kang, Hyeyoung Moon, Donghyun Sinn, Minwoong Kang, Sang Myung Woo, Yoon Jung Chang, Boram Park, Sun-Young Kong, Eliseo Guallar, Soo-Yong Shin, Geunyeon Gwak, Joung Hwan Back, Eun Sook Lee, Juhee Cho, Gianfranco D. Alpini
    PLOS ONE.2021; 16(2): e0246143.     CrossRef
  • Early and Two-year Outcomes after Sutureless and Conventional Aortic Valve Replacement: a Nationwide Population-based Study
    Jae Woong Choi, Ho Jin Kim, Joon Bum Kim, Sak Lee, Cheong Lim, Byung Chul Chang, Youshin Suh, Na Rae Lee, Ho Young Hwang
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Assessment of Trends in the Incidence Rates of Central Retinal Artery Occlusion in Korea From 2002 to 2015
    Jongshin Kim, Seong Jun Byun, Se Joon Woo, Kyu Hyung Park, Sang Jun Park
    JAMA Ophthalmology.2021; 139(4): 399.     CrossRef
  • The incidence of myocardial infarction and stroke in head and neck cancer patients
    Hyun-Keun Kwon, Kyung-Do Han, Yong-Il Cheon, Sung-Chan Shin, Minhyung Lee, Eui-Suk Sung, Jin-Choon Lee, Byung-Joo Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • Long-term impacts of appendectomy associated with increased incidence of inflammatory bowel disease, infection, and colorectal cancer
    Seohee Lee, Eun Jin Jang, Junwoo Jo, So Jung Park, Ho Geol Ryu
    International Journal of Colorectal Disease.2021; 36(8): 1643.     CrossRef
  • Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
    Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
    Scientific Reports.2021;[Epub]     CrossRef
  • Proteinuria Is Associated with the Development of Crohn’s Disease: A Nationwide Population-Based Study
    Seona Park, Hyun Jung Lee, Kyung-Do Han, Hosim Soh, Jung Min Moon, Seung Wook Hong, Eun Ae Kang, Jong Pil Im, Joo Sung Kim
    Journal of Clinical Medicine.2021; 10(4): 799.     CrossRef
  • Lifestyle is associated with atrial fibrillation development in patients with type 2 diabetes mellitus
    Chan Soon Park, Kyung-Do Han, Eue-Keun Choi, Da Hye Kim, Hyun-Jung Lee, So-Ryoung Lee, Seil Oh
    Scientific Reports.2021;[Epub]     CrossRef
  • Determining the association between repeatedly elevated serum gamma‐glutamyltransferase levels and risk of respiratory cancer: A nationwide population‐based cohort study
    Ye Jin Lee, Kyung‐Do Han, Da Hye Kim, Chang‐Hoon Lee
    Cancer Medicine.2021; 10(4): 1366.     CrossRef
  • The Repeatedly Elevated Fatty Liver Index Is Associated With Increased Mortality: A Population-Based Cohort Study
    Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • A nationwide population-based study in South Korea on a relationship between height and anosmia
    Jeong Wook Kang, Young Chan Lee, Kyung Do Han, Kun Hee Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • Effect of healthcare benefits on short‐term adherence of positive airway pressure therapy
    Taehun Lim, Sung Hwan Lim, Beom Mo Koo, Junho Hwang, Joo Hyung Oh, Jihye Rhee, Pona Park
    The Clinical Respiratory Journal.2021; 15(7): 735.     CrossRef
  • Comparative Surgical Outcomes of Prosthetic and Native Valve Endocarditis
    Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
    Korean Circulation Journal.2021; 51(6): 504.     CrossRef
  • Analysis of application of dental sedation in attention deficit hyperactivity disorder (ADHD) patients using the Korean National Health Insurance data
    Seong In Chi, Hyuk Kim, Kwang-Suk Seo
    Journal of Dental Anesthesia and Pain Medicine.2021; 21(2): 99.     CrossRef
  • Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
    Chang-Soon Lee, Young Jae Park, Jee Youn Moon, Yong-Chul Kim
    Anesthesiology.2021; 134(6): 925.     CrossRef
  • Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
    Jong Keun Kim, Young Goo Lee, Kyungdo Han, Jun Hyun Han
    Scientific Reports.2021;[Epub]     CrossRef
  • Pre-transplant Dementia is Associated with Poor Survival After Hematopoietic Stem Cell Transplantation: A Nationwide Cohort Study with Propensity Score Matched Control
    Sheng-Min Wang, Sung-Soo Park, See Hyun Park, Nak-Young Kim, Dong Woo Kang, Hae-Ran Na, Young-Yi Bae, Jong Wook Lee, Seunghoon Han, Hyun Kook Lim
    Clinical Psychopharmacology and Neuroscience.2021; 19(2): 294.     CrossRef
  • Risks and Prognoses of Alzheimer's Disease and Vascular Dementia in Patients With Insomnia: A Nationwide Population-Based Study
    Min Seok Baek, Kyungdo Han, Hyuk-Sung Kwon, Yong-ho Lee, Hanna Cho, Chul Hyoung Lyoo
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • The Association Between Second-Line Oral Antihyperglycemic Medication on Types of Dementia in Type 2 Diabetes: A Nationwide Real-World Longitudinal Study
    Won Jun Kim, Jung Hyun Noh, Kyungdo Han, Cheol-Young Park
    Journal of Alzheimer's Disease.2021; 81(3): 1263.     CrossRef
  • Effect of Short-Term Exposure to Fine Particulate Matter and Temperature on Acute Myocardial Infarction in Korea
    Jiyoung Shin, Jongmin Oh, In-Sook Kang, Eunhee Ha, Wook-Bum Pyun
    International Journal of Environmental Research and Public Health.2021; 18(9): 4822.     CrossRef
  • Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
    Seon Ha Baek, Sehoon Park, Mi-yeon Yu, Ji Eun Kim, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • Proteinuria and Psoriasis Risk: A Nationwide Population-Based Study
    Eun Hui Bae, Bongseong Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
    Journal of Clinical Medicine.2021; 10(11): 2356.     CrossRef
  • Risk of COVID-19 and major adverse clinical outcomes among people with disabilities in South Korea
    Jae Woo Choi, Euna Han, Sang Gyu Lee, Jaeyong Shin, Tae Hyun Kim
    Disability and Health Journal.2021; 14(4): 101127.     CrossRef
  • Use of Proton Pump Inhibitors vs Histamine 2 Receptor Antagonists for the Risk of Gastric Cancer: Population-Based Cohort Study
    Ga-Yeong Shin, Jae Myung Park, Jinhyuk Hong, Yu Kyung Cho, Hyeon Woo Yim, Myung-Gyu Choi
    American Journal of Gastroenterology.2021; 116(6): 1211.     CrossRef
  • Risk of upper gastrointestinal bleeding in patients on oral anticoagulant and proton pump inhibitor co-therapy
    Hyun-Jung Lee, Hyung-Kwan Kim, Bong-Sung Kim, Kyung-Do Han, Jun-Bean Park, Heesun Lee, Seung-Pyo Lee, Yong-Jin Kim, Timir Paul
    PLOS ONE.2021; 16(6): e0253310.     CrossRef
  • Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
    Tak Kyu Oh, Eun Sun Jang, In-Ae Song
    Scientific Reports.2021;[Epub]     CrossRef
  • Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
    Kyung-Hee Cho, Sun U. Kwon, Ji Sung Lee, Sungwook Yu, A-Hyun Cho
    Scientific Reports.2021;[Epub]     CrossRef
  • Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
    Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song, Rajesh Hosadurga
    PLOS ONE.2021; 16(6): e0253257.     CrossRef
  • Anemia May Increase the Overall Risk of Cancer: Findings from a Cohort Study with a 12-Year Follow-up Period in South Korea
    Tak Kyu Oh, In-Ae Song
    Cancer Epidemiology, Biomarkers & Prevention.2021; 30(7): 1440.     CrossRef
  • Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
    Hyunsook Choi, Haine Lee, Sang-Soo Lee, Jeonghoon Ahn, Jin Hyun Joh, Moo-Yeol Lee
    Annals of Surgical Treatment and Research.2021; 101(1): 20.     CrossRef
  • Seasonal variation of patulous Eustachian tube diagnoses using climatic and national health insurance data
    S Lee, S-W Choi, J Kim, H M Lee, S-J Oh, S-K Kong
    The Journal of Laryngology & Otology.2021; 135(8): 695.     CrossRef
  • Clinical Study Using Healthcare Claims Database
    Jin-Su Park, Chan Hee Lee
    Journal of Rheumatic Diseases.2021; 28(3): 119.     CrossRef
  • History of anemia and long-term mortality due to infection: a cohort study with 12 years follow-up in South Korea
    Tak Kyu Oh, Kyung-Ho Song, In-Ae Song
    BMC Infectious Diseases.2021;[Epub]     CrossRef
  • Trends of age‐related non‐communicable diseases in people living with HIV and comparison with uninfected controls: A nationwide population‐based study in South Korea
    Jung Ho Kim, Juhwan Noh, Woojin Kim, Hye Seong, Jun Hyoung Kim, Woon Ji Lee, YaeJee Baek, JongHoon Hyun, Yujin Sohn, Yunsuk Cho, Moo Hyun Kim, SangMin Ahn, Yongseop Lee, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon‐Sup Yeom, Changsoo Kim, Jun Yong Choi
    HIV Medicine.2021; 22(9): 824.     CrossRef
  • Risk of Heart Disease after Cholecystectomy: A Nationwide Population-Based Cohort Study in South Korea
    Yoo Jin Kim, Young Soo Park, Cheol Min Shin, Kyungdo Han, Sang Hyun Park, Hyuk Yoon, Nayoung Kim, Dong Ho Lee
    Journal of Clinical Medicine.2021; 10(15): 3253.     CrossRef
  • Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea
    Se Eun Park, Mi Hae Seo, Jung-Hwan Cho, Hyemi Kwon, Yang-Hyun Kim, Kyung-Do Han, Jin-Hyung Jung, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
    Diabetes & Metabolism Journal.2021; 45(4): 539.     CrossRef
  • Automatic Classification of Thyroid Findings Using Static and Contextualized Ensemble Natural Language Processing Systems: Development Study
    Dongyup Shin, Hye Jin Kam, Min-Seok Jeon, Ha Young Kim
    JMIR Medical Informatics.2021; 9(9): e30223.     CrossRef
  • Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours
    Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung-Young Oh, Ho Geol Ryu
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Prior antiviral treatment and mortality among patients with hepatitis C virus-related hepatocellular carcinoma: A national cohort study
    Dong Hyun Sinn, Danbee Kang, Yun Soo Hong, Kwang Cheol Koh, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak, Luca Rinaldi
    PLOS ONE.2021; 16(8): e0255624.     CrossRef
  • Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
    Yong Suk Jo, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Yuji Kim, Bumhee Yang, Hayoung Choi, Jang Won Sohn, Dong Wook Shin, Hyun Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • Effect of aspirin on coronavirus disease 2019
    Minkook Son, Myung-giun Noh, Jeong Hoon Lee, Jeongkuk Seo, Hansoo Park, Sung Yang
    Medicine.2021; 100(30): e26670.     CrossRef
  • The Association between Peri-Transplant RBC Transfusion and Graft Failure after Kidney Transplantation: A Nationwide Cohort Study
    Kyungho Lee, Seohee Lee, Eun Jin Jang, Ga Hee Kim, Seokha Yoo, Minkyoo Lee, Hye Ryoun Jang, Ho Geol Ryu
    Journal of Clinical Medicine.2021; 10(16): 3750.     CrossRef
  • Empathy With Patients and Post-Traumatic Stress Response in Verbally Abused Healthcare Workers
    Soo-hyun Nam, Dong-Wook Lee, Hwa-yeon Seo, Yun-Chul Hong, Je-Yeon Yun, Sung-jun Cho, Nami Lee
    Psychiatry Investigation.2021; 18(8): 770.     CrossRef
  • Smoking cessation, but not reduction, reduces cardiovascular disease incidence
    Su-Min Jeong, Keun Hye Jeon, Dong Wook Shin, Kyungdo Han, Dahye Kim, Sang Hyun Park, Mi Hee Cho, Cheol Min Lee, Ki-Woong Nam, Seung Pyo Lee
    European Heart Journal.2021; 42(40): 4141.     CrossRef
  • Does Exposure of Lead and Cadmium Affect the Endometriosis?
    Min-Gi Kim, Young-Sun Min, Yeon-Soon Ahn
    International Journal of Environmental Research and Public Health.2021; 18(17): 9077.     CrossRef
  • Association of Periodontal Disease with the Occurrence of Unruptured Cerebral Aneurysm among Adults in Korea: A Nationwide Population-Based Cohort Study
    Ho-Geol Woo, Yoon-Kyung Chang, Ji-Sung Lee, Tae-Jin Song
    Medicina.2021; 57(9): 910.     CrossRef
  • Synergistic harmful interaction between sustained physical inactivity and hypertension/diabetes mellitus on the risk of all-cause mortality: a retrospective observational cohort study
    Chang-Hoon Lee, Kyung-Do Han, Juhwan Yoo, Min-Sun Kwak
    Journal of Hypertension.2021; 39(10): 2058.     CrossRef
  • Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study
    Bumhee Yang, Kyungdo Han, Sang Hyuk Kim, Dong-Hwa Lee, Sang Hyun Park, Jung Eun Yoo, Dong Wook Shin, Hayoung Choi, Hyun Lee
    Nutrients.2021; 13(9): 3206.     CrossRef
  • Particular matter influences the incidence of acute otitis media in children
    Mina Park, Jiyeon Han, Jiwon Park, Myoung-jin Jang, Moo Kyun Park
    Scientific Reports.2021;[Epub]     CrossRef
  • Changes in the Prosthesis Types Used for Aortic Valve Replacement after the Introduction of Sutureless and Rapid Deployment Valves in Korea: A Nationwide Population-Based Cohort Study
    Hyeok Sang Woo, Ho Young Hwang, Ho Jin Kim, Joon Bum Kim, Sak Lee, Cheong Lim, Byung-Cheul Chang, Na Rae Lee, Youshin Suh, Jae Woong Choi
    Journal of Chest Surgery.2021; 54(5): 369.     CrossRef
  • Association between haemorrhagic fever with renal syndrome and cancers
    Yong Jin Yi, Minsun Kang, Won-Keun Kim, Kyungmin Huh, Jonas Klingström, Jin-Won Song, Jaehun Jung
    International Journal of Infectious Diseases.2021; 113: 127.     CrossRef
  • Blood Pressure and Cardiovascular Disease in Older Patients With Diabetes: Retrospective Cohort Study
    Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Relationship between blood pressure levels and ischemic stroke, myocardial infarction, and mortality in very elderly patients taking antihypertensives: a nationwide population-based cohort study
    Myung-Sun Song, Yeon joo Choi, Hyunjin Kim, Myung Ji Nam, Chung-woo Lee, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Do-Hoon Kim, Joo-Hyun Park
    BMC Geriatrics.2021;[Epub]     CrossRef
  • Effects of menopausal hormone therapy on cardiovascular diseases and type 2 diabetes in middle-aged postmenopausal women: analysis of the Korea National Health Insurance Service Database
    Ji-Eun Kim, Jaesung Choi, JooYong Park, Aesun Shin, Nam-Kyong Choi, Ji-Yeob Choi
    Menopause.2021; 28(11): 1225.     CrossRef
  • Epidemiology of Achilles Tendon Rupture in South Korea: Claims Data of the National Health Insurance Service from 2009 to 2017
    Hong-Gi Park, Dukyoung Youn, Jong-Min Baik, Jae Ho Hwang
    Clinics in Orthopedic Surgery.2021; 13(4): 539.     CrossRef
  • Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
    In-Soo Kim, Yeon-Jik Choi, Eui-Young Choi, Pil-Ki Min, Young Won Yoon, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Jong-Youn Kim, Luigi Sciarra
    PLOS ONE.2021; 16(11): e0258770.     CrossRef
  • Comparison of Risk of Pneumonia Caused by Fluticasone Propionate versus Budesonide in Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Cohort Study
    Jae-Hwa Choi, Keun-Bae Jeong, You Hyun Park, Iseul Yu, Seok Jeong Lee, Myoung Kyu Lee, Sang-Ha Kim, Won-Yeon Lee, Suk Joong Yong, Ji-Ho Lee
    International Journal of Chronic Obstructive Pulmonary Disease.2021; Volume 16: 3229.     CrossRef
  • Clinical Impact of Hormone Replacement Therapy on Atrial Fibrillation in Postmenopausal Women: A Nationwide Cohort Study
    Jaehoon Lee, Yuntae Kim, Hyunji Park, Changsoo Kim, Sihyun Cho, Jongyoun Kim
    Journal of Clinical Medicine.2021; 10(23): 5497.     CrossRef
  • Rheumatoid Arthritis in Silica-Exposed Workers
    Young-Sun Min, Min-Gi Kim, Yeon-Soon Ahn
    International Journal of Environmental Research and Public Health.2021; 18(23): 12776.     CrossRef
  • Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study
    Hyun Ji Lee, Kyung Do Han, Hae Eun Park, Ju Hee Han, Chul Hwan Bang, Young Min Park, Ji Hyun Lee
    Scientific Reports.2021;[Epub]     CrossRef
  • Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study
    Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
    Journal of Clinical Medicine.2021; 10(24): 5948.     CrossRef
  • Female Reproductive Factors and Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
    Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Associations of Systolic Blood Pressure With Incident CKD G3-G5: A Cohort Study of South Korean Adults
    Tae Ik Chang, Hyunsun Lim, Cheol Ho Park, Connie M. Rhee, Hamid Moradi, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han
    American Journal of Kidney Diseases.2020; 76(2): 224.     CrossRef
  • Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
    Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Jee-In Heo, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study
    Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song
    Parkinson's Disease.2020; 2020: 1.     CrossRef
  • Physical performance and chronic kidney disease development in elderly adults: results from a nationwide cohort study
    Young Su Joo, Jong Hyun Jhee, Hyung-Woo Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
    Aging.2020; 12(17): 17393.     CrossRef
  • Association Between Income Disparities and Risk of Chronic Kidney Disease
    Tae Ik Chang, Hyunsun Lim, Cheol Ho Park, Connie M. Rhee, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han
    Mayo Clinic Proceedings.2020; 95(2): 231.     CrossRef
  • Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study
    Sheng-Min Wang, Sung-Soo Park, Si-Hyun Park, Nak-Young Kim, Dong Woo Kang, Hae-Ran Na, Jong Wook Lee, Seunghoon Han, Hyun Kook Lim
    Scientific Reports.2020;[Epub]     CrossRef
  • Label Adherence of Direct Oral Anticoagulants Dosing and Clinical Outcomes in Patients With Atrial Fibrillation
    Hee Tae Yu, Pil‐Sung Yang, Eunsun Jang, Tae‐Hoon Kim, Jae‐Sun Uhm, Jong‐Youn Kim, Hui‐Nam Pak, Moon‐Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Associations among Obesity Degree, Glycemic Status, and Risk of Heart Failure in 9,720,220 Korean Adults
    Eun-Jung Rhee, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Won-Young Lee
    Diabetes & Metabolism Journal.2020; 44(4): 592.     CrossRef
  • Obesity Fact Sheet in Korea, 2019: Prevalence of Obesity and Abdominal Obesity from 2009 to 2018 and Social Factors
    Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Eun-Jung Rhee, Seong-Su Lee, Dae Jung Kim, Kwan-Woo Lee, Won-Young Lee
    Journal of Obesity & Metabolic Syndrome.2020; 29(2): 124.     CrossRef
  • Safety of acupuncture during pregnancy: a retrospective cohort study in Korea
    H‐Y Moon, M‐r Kim, D‐S Hwang, J‐B Jang, J Lee, J‐S Shin, I Ha, YJ Lee
    BJOG: An International Journal of Obstetrics & Gynaecology.2020; 127(1): 79.     CrossRef
  • Bell’s palsy and obesity, alcohol consumption and smoking: A nested case-control study using a national health screening cohort
    So Young Kim, Dong Jun Oh, Bumjung Park, Hyo Geun Choi
    Scientific Reports.2020;[Epub]     CrossRef
  • Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study
    Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study
    Min-Kyung Lee, Kyungdo Han, Mee Kyoung Kim, Eun Sil Koh, Eun Sook Kim, Ga Eun Nam, Hyuk-Sang Kwon
    Scientific Reports.2020;[Epub]     CrossRef
  • Increased Cardiovascular Risk and All-cause Death in Patients with Behçet Disease: A Korean Nationwide Population-based Dynamic Cohort Study
    Hyo-Suk Ahn, Dongjae Lee, Soo Young Lee, Yeong Ho Kim, Ji Hyun Lee, Dong Soo Yu, Kyung-Do Han, Yong Gyu Park, Young Bok Lee
    The Journal of Rheumatology.2020; 47(6): 903.     CrossRef
  • Gamma-Glutamyl Transferase Variability and Risk of Dementia in Diabetes Mellitus: A Nationwide Population-Based Study
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  • The Population Prevalence, Associations of Congenital Heart Defect and Mortality Risk for Down’s Syndrome in South Korea Based on National Health Insurance Service (NHIS) Data


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    Jun Yup Kim, Keon-Joo Lee, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Seong-Eun Kim, Heeyoung Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Moo-Seok Park, Sang-Soon Park, Kyung Bok Lee, Hong-Kyun Park,
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  • Impact of Mitral Valve Repair Case Volume on Postoperative Mortality ― A Nationwide Korean Cohort Study ―
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  • The Clinical Impact of Body Mass Index on Breast Cancer in Korea: A Nationwide Population-Based Cohort Study
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  • Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide population-based cohort study
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  • Pneumonia risk and its associated factors in Parkinson's disease: A National Database Study
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  • The Association with rhegmatogenous retinal detachment and paediatric atopic dermatitis: a 12-year Nationwide Cohort Study
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  • Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study


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  • The Burden of Cervical Cancer in Korea: A Population-Based Study
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  • Trend of prevalence and incidence of systemic lupus erythematosus in South Korea, 2005 to 2015: a nationwide population-based study
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  • Association between Height and Actinic Keratosis: A Nationwide Population-based Study in South Korea
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Increasing Prevalence of Type 2 Diabetes in a Rural Bangladeshi Population: A Population Based Study for 10 Years
Bishwajit Bhowmik, Faria Afsana, Lien My Diep, Sanjida Binte Munir, Erica Wright, Sharif Mahmood, A. K. Azad Khan, Akhtar Hussain
Diabetes Metab J. 2013;37(1):46-53.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.46
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AbstractAbstract PDFPubReader   
Background

To observe changes in the prevalence of type 2 diabetes mellitus (DM) and impaired fasting glucose (IFG) and its associated risk factors in a rural Bangladeshi population over a 10-year period.

Methods

Three cross-sectional studies were undertaken in a rural community (aged ≥20 years) in 1999, 2004, and 2009. Structured questionnaires including sociodemographic parameters, anthropometric measurements, blood pressure, and blood glucose values were recorded. DM and IFG were diagnosed using 1999 World Health Organization criteria.

Results

Age standardized prevalence of DM increased significantly (P<0.001) from 1999 to 2009 (2.3%, 6.8%, and 7.9% in 1999, 2004, and 2009, respectively). The prevalence of IFG increased significantly (P=0.011) from 4.6% to 5.8% between 1999 and 2004 but then decreased from 5.8% to 5.3% during 2004 to 2009. Significant linear trends were shown in both sexes for general and central obesity as indicated by body mass index, waist circumference, and waist hip ratio (WHR). Increasing age and systolic blood pressure were significant risk factors for DM in all three studies. WHR for males was also significantly associated with the risk of DM in all three studies. WHR for females was only significantly associated with DM in 2009.

Conclusion

A significant rise in the prevalence of DM was observed in this population over 10 years. This increase was seen in both sexes, and in all age groups. A significant increase in the prevalence of the associated risk factors of general and central obesity was observed in both sexes.

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Leptin Concentration in Diabetin and Non-diabetin Subjects in the Community Population.
Kee Up Lee, Seong Kwan Hong, Sang Wook Kim, Young Il Kim, Yun Ey Chung, Moo Song Lee, Joong Yeoul Park, Jin Yup Kim
Korean Diabetes J. 1999;23(4):592-600.   Published online January 1, 2001
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AbstractAbstract PDF
BACKGROUND
It has been suggested that adipose tissue releases leptin, a satiety factor, which circulates in blood and acts on the hypothalamus to suppress appetite. However, serum leptin concentration in obese human subjects is higher than that in lean subjects, suggesting leptin resistance. Although there have been several studies investigating serum leptin concentrations in Korean subjects, there has been no population-based study. This study was undertaken to investigate serum leptin concentration and associated factors in diabetic and non-diabetic subjects living in a rural area of Korea. METHOD: Among 898 subjects originally included in the Jung-up epidemiologic study, 119 men and 124 women with varying degrees of glucose tolerance were randomly selected. Serum leptin concentration was measured by radioimmunoassay. RESULTS: In agreement with previous studies, women had significantly higher serum leptin concentration than men. Serum leptin concentration in Korean men and women was apparently lower than in other populations, even after adjustment for BMI. Leptin concentration was not different among the three groups of glucose tolerance (normal glucose tolerance, impaired glucose tolerance and diabetes). Serum leptin concentration was positively correlated with serum true insulin, proinsulin and BMI in non-diabetic subjects. Serum leptin concentration was also significantly related with serum proinsulin/true insulin ratio in non-diabetic women. CONCLUSION: Serum leptin concentration in Korean subjects was lower than that reported in other populations. Serum leptin concentration was associated with BMI, serum true insulin and proinsulin levels in non-diabetic subjects, but not in diabetic ubjects.
The Appropriteness of New ADA Diagnostin Criteria for Diabetes Mellitus in Korean Population.
Moon kyu Lee, Myung Shik Lee, Young Ki Min, Sung Hoon Kim, Byoung Joon Kim, Dong Jun Kim, Jong Ryeal Hahm, Eun Young Oh, Yun Jae Chung, Kyoung Ah Kim, Jae Hoon Chung, Kwang Won Kim
Korean Diabetes J. 1999;23(3):336-351.   Published online January 1, 2001
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AbstractAbstract PDF
BACKGROUND
The ADA has proposed a new diagnostic criteria for diabetes based on fasting plasma glucose, redefining diabetes as fasting plasma glucose 7.0 mmol/L. Since only a few studies for the appropriateness of tbis new ADA criteria were undertaken in the Korean population, we examined the appropriateness of the new ADA criteria by analyzing the results of oral glucose tolerance tests done in our hospital. METHODS: 507 oral glucose tolerance tests were conducted. Cases with diabetes and diseases that could affect the glucose tolerance were excluded. Plasma glucose was measured by the hexokinase method. Three groups of NGT, IGT, and DM by the WHO criteria of 2 hour-plasma glucose were redivided at each level of fasting plasma glucose. We calculated the sensitivity and specificity of each level of fasting plasma glucose (FPG), and the FPG value of maximum accuracy to diagnose diabetes with reference to the WHO criteria of 2 hour-plasma glucose. RESULTS: Correlation between the levels of fasting plasma glucose and 2 hour-plasma glucose was relatively low (r=0.676). FPG of 7.0 mmol/L for diagnosing diabetes was relatively specific (specificity=0.934), but not sensitive (sensitivity= 0.552). FPG value of maximum accuracy for diagnosing diabetes was 6.8 mmol/L. 39 % of IFG (> 6.1mmol/L and < 7.0mmol/L) was reclassified as diabetes by the criteria of 2 hour plasma glucose 11.1 mmol/L and 34 % of NFG (<6.1mmol/L) was reclassified as impaired glucose tolerance by the criteria of 2 hour plasma glucose > 7.8 mmol/L. CONCLUSION: The fasting plasma glucose of 7.0 mmol/L was relatively specific for diagnosing diabetes. However, the new ADA criteria tended to underestimate the prevalence of diabetes and impaired glucose tolerance in the Korean population. Therefore, oral glucose tolerance test may be needed to diagnose diabetes in high risk subjects. Large-scale cross-sectional and prospective studies will be needed to clarify these points.
Microalbuminuria in Diabetic and Non-diabetic Subjects: A population Based Study.
Young Il Kim, Yun Ey Chung, Jin Yup Kim, Sang Wook Kim, Eun Sook Kim, Moo Song Lee, Joong Yeoul Park, Sung Kwan Hong, Ki Up Lee
Korean Diabetes J. 1999;23(1):79-86.   Published online January 1, 2001
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AbstractAbstract PDF
BACKGROUND
Microalbuminuria is associated with increased cardiovascular mortality in type 2 diabetic patients and non-diabetic subjects. This study was undertaken to determine the prevalence ot microalbuminuria among diabetic and non-diabetic subjects in Korea and to determine the factors associated with microalbuminuria. METHOD: A sample of 1,791 subjects aged > 40 years living in Jungup district were selected from the 28,380 inhabitants using a random cluster sampling method. Among these subjects, 1,006 of them (56.1%) underwent the 75 g oral glucose tolerance test that was also part of the timed overnight urine collection. 46 subjects were excluded because they had signs of urinary tract infection (n=41) or overt proteinuria (n=5). Microalbuminuria was defined as urinary albumin excretion rate (UAER) between 20 and 200 pg/min. RESULTS: Subjects with microalbuminuria had a higher weight and body mass index (BMI), abdominal circumference, systolic and diastolic blood pressure (BP), fasting and 2hr plasma glucose, fasting semm insulin and proinsulin concentrations than subjects without microalbuminuria. The prevalence of micro- albuminuria increased as the glucose tolerance worsened[6.0% in normal glucose tolerance, 11.8% in impaired glucose tolerance (IGT) and 21.8% in diabetes, respectively; x trend=25.9, p<0.(0001]. Mean UAER of subjects with hypertension was greater than that of subjects without hypertension (7.8+0.9ug/min vs. 9.6+0.7ug/min, p<0.001). Univariate analysis revealed that the UAER was significantly (p<0.05) correlated with weight and BMI, abdominal circumference, systolic and diastolic BP, fasting and 2hr plasma glucose, fasting serum insulin and proinsulin after sex-adjustment. Multiple regression analysis revealed that weight or BMI, diastolic BP, 2hr plasma glucose and fasting serum insulin were independently associated with UAER in non-diabetic subjects. CONCLUSION: The present study demonstrates that the prevalence of microalburninuria is higher in patients with glucose intolerance. The association of the UAER with BMI, diastolic BP, 2hr plasma glucose and fasting serum insulin suggest that microalbuminuria is a feature of the insulin resistance syndrome.

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