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Interrelationships between the Retinal Neuroglia and Vasculature in Diabetes
Timothy S. Kern
Diabetes Metab J. 2014;38(3):163-170.   Published online June 17, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.3.163
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AbstractAbstract PDFPubReader   

For years, diabetic retinopathy has been defined based on vascular lesions, and neural abnormalities were not regarded as important. This review summarizes evidence that the neural retina has important effects on the retinal vasculature under normal conditions, and the interaction between the retinal neuroglial cells and vascular function is altered in diabetes. Importantly, new evidence raises a possibility that abnormalities within retinal neuroglial cells (notably photoreceptors) might actually be causing or initiating the vascular disease in diabetic retinopathy.

Citations

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  • A Systematic Review of Carotenoids in the Management of Diabetic Retinopathy
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    Current Bioactive Compounds.2021;[Epub]     CrossRef
  • Looking Ahead: Visual and Anatomical Endpoints in Future Trials of Diabetic Macular Ischemia
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  • Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice
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  • Targeting Neurovascular Interaction in Retinal Disorders
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    International Journal of Molecular Sciences.2020; 21(4): 1503.     CrossRef
  • Glycine receptor is differentially expressed in the rat retina at early stages of streptozotocin-induced diabetes
    Elizabeth Morales-Calixto, Miguel Ángel Velázquez-Flores, Gustavo Sánchez-Chávez, Ruth Ruiz Esparza-Garrido, Rocío Salceda
    Neuroscience Letters.2019; 712: 134506.     CrossRef
  • Effect of Autophagy Modulators on Vascular, Glial, and Neuronal Alterations in the Oxygen-Induced Retinopathy Mouse Model
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    Frontiers in Cellular Neuroscience.2019;[Epub]     CrossRef
  • Retinal Sensitivity Loss Correlates with Deep Capillary Plexus Impairment in Diabetic Macular Ischemia
    Fabio Scarinci, Monica Varano, Mariacristina Parravano
    Journal of Ophthalmology.2019; 2019: 1.     CrossRef
  • Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy
    S. Priya Narayanan, Esraa Shosha, Chithra D Palani
    Pharmacological Research.2019; 147: 104299.     CrossRef
  • Translational research in retinal vascular disease. An approach
    Toke Bek
    Acta Ophthalmologica.2019; 97(5): 441.     CrossRef
  • Protective Effects of Leukemia Inhibitory Factor on Retinal Vasculature and Cells in Streptozotocin-induced Diabetic Mice
    Xiu-Fen Yang, Ying-Xiang Huang, Ming Lan, Tao-Ran Zhang, Jie Zhou
    Chinese Medical Journal.2018; 131(1): 75.     CrossRef
  • SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets
    Maria Vähätupa, Janika Nättinen, Antti Jylhä, Ulla Aapola, Marko Kataja, Peeter Kööbi, Tero A. H. Järvinen, Hannu Uusitalo, Hannele Uusitalo-Järvinen
    Investigative Opthalmology & Visual Science.2018; 59(8): 3294.     CrossRef
  • Association Between Vessel Density and Visual Acuity in Patients With Diabetic Retinopathy and Poorly Controlled Type 1 Diabetes
    Bénédicte Dupas, Wilfried Minvielle, Sophie Bonnin, Aude Couturier, Ali Erginay, Pascale Massin, Alain Gaudric, Ramin Tadayoni
    JAMA Ophthalmology.2018; 136(7): 721.     CrossRef
  • Diabetic macular oedema: clinical risk factors and emerging genetic influences
    Ebony Liu, Jamie E Craig, Kathryn Burdon
    Clinical and Experimental Optometry.2017; 100(6): 569.     CrossRef
  • Comparison of spectral-domain optical coherence tomography for intra-retinal layers thickness measurements between healthy and diabetic eyes among Chinese adults
    Shu-ting Li, Xiang-ning Wang, Xin-hua Du, Qiang Wu, Demetrios G. Vavvas
    PLOS ONE.2017; 12(5): e0177515.     CrossRef
  • RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis
    Ye Sun, Chi‐Hsiu Liu, Zhongxiao Wang, Steven S. Meng, Samuel B. Burnim, John Paul SanGiovanni, Theodore M. Kamenecka, Laura A. Solt, Jing Chen
    The FASEB Journal.2017; 31(10): 4492.     CrossRef
  • Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina
    Dalia Al-Dosari, Mohammed Ahmed, Salim Al-Rejaie, Abdullah Alhomida, Mohammad Ola
    Nutrients.2017; 9(10): 1161.     CrossRef
  • Do photoreceptor cells cause the development of retinal vascular disease?
    Timothy S. Kern
    Vision Research.2017; 139: 65.     CrossRef
  • Putative protective role of lutein and zeaxanthin in diabetic retinopathy
    Kumari Neelam, Catherina J Goenadi, Katherine Lun, Chee Chew Yip, Kah-Guan Au Eong
    British Journal of Ophthalmology.2017; 101(5): 551.     CrossRef
  • Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy
    Katherine J Wert, Vinit B Mahajan, Lijuan Zhang, Yuanqing Yan, Yao Li, Joaquin Tosi, Chun Wei Hsu, Takayuki Nagasaki, Kerstin M Janisch, Maria B Grant, MaryAnn Mahajan, Alexander G Bassuk, Stephen H Tsang
    Signal Transduction and Targeted Therapy.2016;[Epub]     CrossRef
  • Poly(ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors Reduce Reactive Gliosis and Improve Angiostatin Levels in Retina of Diabetic Rats
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    Neurochemical Research.2016; 41(10): 2526.     CrossRef
  • Neuroprotective actions of progesterone in an in vivo model of retinitis pigmentosa
    V. Sánchez-Vallejo, S. Benlloch-Navarro, R. López-Pedrajas, F.J. Romero, M. Miranda
    Pharmacological Research.2015; 99: 276.     CrossRef
  • Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview
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    BioMed Research International.2015; 2015: 1.     CrossRef
  • Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy
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    Progress in Retinal and Eye Research.2015; 48: 40.     CrossRef
  • Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence
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    Progress in Retinal and Eye Research.2015; 48: 160.     CrossRef
  • SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth
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    Science Signaling.2015;[Epub]     CrossRef
  • Enriched Environment Protects the Optic Nerve from Early Diabetes-Induced Damage in Adult Rats
    Damián Dorfman, Marcos L. Aranda, Ruth E. Rosenstein, Rafael Linden
    PLOS ONE.2015; 10(8): e0136637.     CrossRef
  • Epigenetic Modifications and Potential New Treatment Targets in Diabetic Retinopathy
    Lorena Perrone, Carmela Matrone, Lalit P. Singh
    Journal of Ophthalmology.2014; 2014: 1.     CrossRef

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