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Diabetes Metab J : Diabetes & Metabolism Journal



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Prevalence of Metabolic Syndrome in Young Korean Women with Polycystic Ovary Syndrome.
Hyejin Lee, Jee Young Oh, Youngsun Hong, Yeon Ah Sung, Hyewon Chung
Korean Diabetes J. 2006;30(4):285-291.   Published online July 1, 2006
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  • 3 Crossref
AbstractAbstract PDF
Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and consequent hyperinsulinemia. Insulin resistance plays an important role in the development of metabolic syndrome (MS). We conducted a cross-sectional study to determine the prevalence of the MS and whether the insulin resistance or hyperandrogenemia is related to the MS in young Korean women with PCOS. METHODS: 143 women with PCOS (mean age 26+/-5 years) were studied to evaluate the prevalence of MS by modified Adult Treatment Panel III. Insulin sensitivity was evaluated by euglycemic hyperinsulinemic clamp technique. RESULTS: The prevalence of MS in women with PCOS was 11.9%, 2.8-fold higher than age matched women in Korean urban population. The most frequent component of MS was low HDL cholesterol (39.4%), and the least frequent one was high fasting serum glucose levels (6.7%). The frequency of MS was 40.7% in obese PCOS (BMI > or = 25 kg/m2, n = 38), 10.0% in overweight PCOS (BMI 23~24.9 kg/m2, n = 13), and 0% in lean PCOS (BMI < 23 kg/m2, n = 92). The frequency of MS was 26.1% in insulin resistant PCOS (insulin mediated glucose uptake, IMGU < lowest 10th percentile of lean controls, n = 65), whereas no one had MS in insulin sensitive PCOS (IMGU > or = lowest 10th percentile of lean controls, n = 78). CONCLUSION: MS is frequent in young women with PCOS, and obesity and insulin resistance might be essential for the development of MS in this study group.


Citations to this article as recorded by  
  • Relationship between flavonoids intake and metabolic syndrome in Korean women with polycystic ovary syndrome
    Ji Soo Oh, Mi Jin Ahn, Chan Jung Han, Hyesook Kim, Oran Kwon, Hye Won Chung, Namsoo Chang
    Journal of Nutrition and Health.2014; 47(3): 176.     CrossRef
  • Inappropriate gonadotropin secretion in polycystic ovary syndrome: The relationship with clinical, hormonal and metabolic characteristics
    A Ra Shim, Yu Im Hwang, Kyung Jin Lim, Young Mi Choi, Young Eun Jeon, Seok Kyo Seo, Si Hyun Cho, Young Sik Choi, Byung Seok Lee
    Korean Journal of Obstetrics & Gynecology.2011; 54(11): 659.     CrossRef
  • Diagnosis and Treatment of Polycystic Ovary Syndrome
    Hyejin Lee, Yeon-ah Sung
    Journal of Korean Endocrine Society.2007; 22(4): 252.     CrossRef
Serum Adiponectin, TNF-alpha, IL-6 and Insulin Resistance in Women with Polycystic Ovary Syndrome.
Young A Kim, Jung Hyun Noh, Dong Jun Kim, Tae Hyun Um, Chong Rae Cho, Na young Jang, Soo Kyung Kwon, Soon Hee Lee, Jeong Hyun Park, Kyung Soo Ko, Byoung Doo Rhee, Kyung Ho Lim
Korean Diabetes J. 2006;30(2):104-111.   Published online March 1, 2006
  • 2,651 View
  • 19 Download
  • 1 Crossref
AbstractAbstract PDF
To determine plasma adipokines such as adiponectin, IL-6 and TNF-alpha concentrations in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adipocytokines to the hormonal and metabolic parameters, including measures of insulin resistance (IR). METHODS: Forty-four selected women were classified as follows: 13 obese (body mass index [BMI] > or = 25 kg/m(2)) with PCOS; 15 non-obese (BMI < 25 kg/m(2)) with PCOS; 8 obese without PCOS, and 8 non-obese without PCOS. Blood samples were collected from all women with or without PCOS after an overnight fast. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), insulin, glucose, adiponectin, TNF-alpha and IL-6 were measured. Measures of IR included HOMA-IR and QUICKI. RESULTS: In non-obese group, fasting insulin levels and HOMA-IR in PCOS were significantly higher compared to control. However, Adiponectin, TNF-alpha and IL-6 concentrations were found not to be different in obese women with PCOS as compared with obese women without PCOS and in non-obese women with PCOS as compared with non-obese women without PCOS. Adiponectin concentrations correlated inversely with BMI, waist circumference (WC), total fat mass, serum insulin, and HOMA-IR in PCOS group. However, multiple regression analysis showed that BMI was the only independent determinant of adiponectin concentration. CONCLUSION: Our results suggest that insulin sensitivity per se probably does not play any role in the control of adipokines levels such as adiponectin, TNF-alpha and IL-6 in PCOS women


Citations to this article as recorded by  
  • Adiponectin in Women with Polycystic Ovary Syndrome
    Hyun-Young Shin, Duk-Chul Lee, Ji-Won Lee
    Korean Journal of Family Medicine.2011; 32(4): 243.     CrossRef

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