Diabetes & Metabolism Journal

Review

Oxidative Stress and Cell Dysfunction in Diabetes: Role of ROS Produced by Mitochondria and NAD(P)H Oxidase.: Sang Soo Kim, Seok Man Son; Korean Diabetes J. 2008;32(5):389-398. Published online October 1, 2008; DOI: https://doi.org/10.4093/kdj.2008.32.5.389

2,979 View
89 Download
10 Crossref

Oxidative stress has been considered to be a major contributor to the pathogenesis of the diabetic macrovascular and microvascular complications. In the absence of an appropriate antioxidant defense mechanism, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause damage and contribute to the late complications ofdiabetes. The source of reactive oxygen species (ROS) in the pancreatic beta cells and insulin sensitive cells has postulated to be the mitochondrial electron transport chain. NAD(P)H oxidase-dependent ROS production is also important as the source both in pancreatic beta cells and other cells. NAD(P)H oxidase mediated ROS can alter parameters of signal transduction, insulin secretion, insulin action, cell proliferation and cell death. Additionally, oxidative stress as the pathogenic mechanism linking insulin resistance with dysfunction of both pancreatic beta cells and endothelial cells, eventually leads to diabetes and its complications. Further investigation of the mechanisms and its therapeutic interventions based on focusing NAD(P)H oxidase associated ROS production in the islet cells and other islet cells are needed

Citations

Citations to this article as recorded by

Cytoprotective Effect of Hot-Water Extracts of Protaetia brevitarsis seulensis Larvae in Cisplatin-Treated Macrophages
Bo-Gyeong Yoo, Jun-Pyo Hong, Ha-Yeon Song, Eui-Hong Byun
Journal of the Korean Society of Food Science and Nutrition.2022; 51(12): 1252. CrossRef
The Effects of LR3 and SP6 Acupuncture on Renal Damage in Streptozotocin-induced Diabetic Mice
Cho In Lee, Hyun Jong Lee, Yun Kyu Lee, Seong Chul Lim, Jae Soo Kim
The Acupuncture.2015; 32(3): 41. CrossRef
Effect of Chungkukjang supplementation on oxidative stress and antioxidant nutrients of diabetic rats induced by streptozotocin
Heyun-Sook Park, Hyun-Joo Kong, Eon-Hee Lee, Eun-Mi Choi, Joung-Hyeon Jang, Myoung-Hee Lee, Ju-Yeon Hong, Su-Jung Hwang, Hyeon-A Jung, Kyung-Mi Yang
Korean Journal of Food Preservation.2015; 22(2): 281. CrossRef
The Effects of Several Halophytes on Insulin Resistance in Otsuka Long-evans Tokushima Fatty Rats
Jeong-Yong Cho, Zhangjun Huang, Sun-Young Park, Kyung-Hee Park, Tong-Kun Pai, So-Young Kim, Haeng-Ran Kim, Kyung-Sik Ham
Korean Journal of Food Science and Technology.2014; 46(1): 100. CrossRef
Protective Effects of Radiation-induced Blackberry Mutant Extract on Carbon Tetrachloride (CCl4)-induced Liver Injury in Sprague-Dawley Rats
Byoung Ok Cho, Chang-Wook Lee, Yangkang So, Chang-Hyun Jin, Hong-Sun Yook, Myung-Woo Byun, Yong-Wook Jeong, Jong Chun Park, Il-Yun Jeong
Journal of the Korean Society of Food Science and Nutrition.2014; 43(6): 807. CrossRef
Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants
Hyun Sook Kim, Tae Woo Kim, Dae Jung Kim, Jae Sung Lee, Kyoung Kon Kim, Myeon Choe
Korean Journal of Medicinal Crop Science.2013; 21(3): 197. CrossRef
Antioxidant Effect of Hot water and Ethanol extracts from Cheonnyuncho (Opuntia humifusa) on Reactive Oxygen Species (ROS) Production in 3T3-L1 Adipocytes
Bo-Ra Yoon, Young-Jun Lee, Sun-Gu Kim, Jung-Young Jang, Hyo-Ku Lee, Seong-Kap Rhee, Hee-Do Hong, Hyeon-Son Choi, Boo-Yong Lee, Ok-Hwan Lee
Korean Journal of Food Preservation.2012; 19(3): 443. CrossRef
Inhibitory Effects of Panax ginseng C. A. Mayer Treated with High Temperature and High Pressure on Oxidative Stress
Bo-Ra Yoon, Young-Jun Lee, Hee-Do Hong, Young-Chul Lee, Young-Chan Kim, Young Kyoung Rhee, Kyung-Tack Kim, Ok-Hwan Lee
The Korean Journal of Food And Nutrition.2012; 25(4): 800. CrossRef
Effect of Dietary Supplementation of β-Carotene on Hepatic Antioxidant Enzyme Activities and Glutathione Concentration in Diabetic Rats
Jung-Hyun Jang, Kyeung-Soon Lee, Jung-Sook Seo
Journal of the Korean Society of Food Science and Nutrition.2011; 40(8): 1092. CrossRef
An Association between 609 C →T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population
Dohee Kim
Korean Diabetes Journal.2009; 33(1): 24. CrossRef

First
Prev
Page of 1
Next
Last

Search