Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
3 "Lipotoxicity"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
Obesity and Metabolic Syndrome
In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-Cells
Claudia Velasquez, Juan Sebastian Vasquez, Norman Balcazar
Diabetes Metab J. 2017;41(4):303-315.   Published online May 24, 2017
DOI: https://doi.org/10.4093/dmj.2017.41.4.303
  • 3,963 View
  • 38 Download
  • 8 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic β-cells. We evaluated the effect of FFAs reconstituted according to the profile of circulating fatty acids found in obese adolescents on the viability and function of the murine insulinoma cell line (mouse insulinoma [MIN6]).

Methods

From fatty acids obtained commercially, plasma-FFA profiles of three different youth populations were reconstituted: obese with metabolic syndrome; obese without metabolic syndrome; and normal weight without metabolic syndrome. MIN6 cells were treated for 24 or 48 hours with the three FFA profiles, and glucose-stimulated insulin secretion, cell viability, mitochondrial function and antioxidant activity were evaluated.

Results

The high FFA content and high polyunsaturated ω6/ω3 ratio, present in plasma of obese adolescents with metabolic syndrome had a toxic effect on MIN6 cell viability and function, increasing oxidative stress and decreasing glucose-dependent insulin secretion.

Conclusion

These results could help to guide nutritional management of obese young individuals, encouraging the increase of ω-3-rich food consumption in order to reduce the likelihood of deterioration of β-cells and the possible development of type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • The reversible effects of free fatty acids on sulfonylurea-stimulated insulin secretion are related to the expression and dynamin-mediated endocytosis of KATP channels in pancreatic β cells
    Chenmin Wei, Zichen Zhang, Qi Fu, Yunqiang He, Tao Yang, Min Sun
    Endocrine Connections.2023;[Epub]     CrossRef
  • Preparation of fatty acid solutions exerts significant impact on experimental outcomes in cell culture models of lipotoxicity
    Axel Römer, Divya Rawat, Thomas Linn, Sebastian F Petry
    Biology Methods and Protocols.2022;[Epub]     CrossRef
  • Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review
    Axel Römer, Thomas Linn, Sebastian F. Petry
    Antioxidants.2021; 10(2): 293.     CrossRef
  • Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
    Petr Ježek, Martin Jabůrek, Lydie Plecitá-Hlavatá
    Antioxidants & Redox Signaling.2019; 31(10): 722.     CrossRef
  • The role of polyunsaturated fatty acids (n-3 PUFAs) on the pancreatic β-cells and insulin action
    Habtamu Wondifraw Baynes, Seifu Mideksa, Sintayehu Ambachew
    Adipocyte.2018; : 1.     CrossRef
  • Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
    Petr Ježek, Martin Jabůrek, Blanka Holendová, Lydie Plecitá-Hlavatá
    Molecules.2018; 23(6): 1483.     CrossRef
Reviews
Others
Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis
Davide Povero, Ariel E. Feldstein
Diabetes Metab J. 2016;40(1):1-11.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.1
  • 6,047 View
  • 55 Download
  • 45 Web of Science
  • 46 Crossref
AbstractAbstract PDFPubReader   

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, host genetics, and gut microbiota leads to excessive accumulation of lipids in the liver (steatosis), which may result in lipotoxicity and trigger hepatocyte cell death, liver inflammation, fibrosis, and pathological angiogenesis. NASH can further progress towards liver cirrhosis and cancer. Over the last few years, cell-derived extracellular vesicles (EVs) have been identified as effective cell-to-cell messengers that transfer several bioactive molecules in target cells, modulating the pathogenesis and progression of NASH. In this review, we focused on recently highlighted aspects of molecular pathogenesis of NASH, mediated by EVs via their bioactive components. The studies included in this review summarize the state of art regarding the role of EVs during the progression of NASH and bring novel insight about the potential use of EVs for diagnosis and therapeutic strategies for patients with this disease.

Citations

Citations to this article as recorded by  
  • Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats
    Esra Palabiyik, Ayse Nurseli Sulumer, Handan Uguz, Bahri Avci, Seda Askin, Hakan Askin
    European Journal of Lipid Science and Technology.2024;[Epub]     CrossRef
  • Extracellular Vesicles and Their Correlation with Inflammatory Factors in an Experimental Model of Steatotic Liver Disease Associated with Metabolic Dysfunction
    Melina Belén Keingeski, Larisse Longo, Vitória Brum da Silva Nunes, Fabrício Figueiró, Danieli Rosane Dallemole, Adriana Raffin Pohlmann, Thalia Michele Vier Schmitz, Patrícia Luciana da Costa Lopez, Mário Reis Álvares-da-Silva, Carolina Uribe-Cruz
    Metabolic Syndrome and Related Disorders.2024;[Epub]     CrossRef
  • β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
    Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail, Mostafa A. Farrag
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • Phospholipid metabolism in the liver – Implications for phosphatidylserine in non-alcoholic fatty liver disease
    Marziyeh Anari, Magdalene K. Montgomery
    Biochemical Pharmacology.2023; 213: 115621.     CrossRef
  • Exosome GLUT1 derived from hepatocyte identifies the risk of non-alcoholic steatohepatitis and fibrosis
    Wenyan Zhang, Jing Zhang, Honglin Shi, Fang Liu, Haibin Yu, Hongbo Shi
    Hepatology International.2023; 17(5): 1170.     CrossRef
  • Role of extracellular vesicles in nonalcoholic fatty liver disease
    Wei Jiang, Youhui Xu, Jou-Chen Chen, Yi-Hung Lee, Yushin Hu, Chang-Hai Liu, Enqiang Chen, Hong Tang, Hua Zhang, Dongbo Wu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Angiopoietin-2 levels correlates with disease activity in children with nonalcoholic fatty liver disease
    Melania Manco, Nadia Panera, Annalisa Crudele, Maria Rita Braghini, Marzia Bianchi, Donatella Comparcola, Rita De Vito, Giuseppe Maggiore, Anna Alisi
    Pediatric Research.2022; 91(7): 1781.     CrossRef
  • The Neglected Role of Bile Duct Epithelial Cells in NASH
    Massimiliano Cadamuro, Alberto Lasagni, Samantha Sarcognato, Maria Guido, Roberto Fabris, Mario Strazzabosco, Alastair J. Strain, Paolo Simioni, Erica Villa, Luca Fabris
    Seminars in Liver Disease.2022; 42(01): 034.     CrossRef
  • Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: A systematic review and meta-analysis
    Binjing Pan, Jing Cai, Pingping Zhao, Jingfang Liu, Songbo Fu, Gaojing Jing, Qianglong Niu, Qiong Li
    Osteoporosis International.2022; 33(11): 2275.     CrossRef
  • Ethanol Extract of Pinus koraiensis Leaves Mitigates High Fructose-Induced Hepatic Triglyceride Accumulation and Hypertriglyceridemia
    Min-Ho Lee, Sunyeong Park, Yinzhu Xu, Jung-Eun Kim, Hengmin Han, Jae-Hyeon Lee, Jean Kyung Paik, Hyo-Jeong Lee
    Applied Sciences.2022; 12(13): 6745.     CrossRef
  • TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis
    Yanmei Zhang, Xiaoxiao Ge, Yongqing Li, Bingyang Zhang, Peijun Wang, Mingju Hao, Peng Gao, Yueyi Zhao, Tao Sun, Sumei Lu, Wanshan Ma
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Tabebuia rosea (Bertol.) DC. ethanol extract attenuates body weight gain by activation of molecular mediators associated with browning
    Elsa Cecilia Pagaza-Straffon, Carla Elena Mezo-González, David Armando Chavaro-Pérez, Jorge Cornejo-Garrido, Laurence A. Marchat, Claudia G. Benítez-Cardoza, Maricruz Anaya-Reyes, Cynthia Ordaz-Pichardo
    Journal of Functional Foods.2021; 86: 104740.     CrossRef
  • Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
    Zhangya He, Xiaomin Li, Hexiang Yang, Pei Wu, Shanshan Wang, Dan Cao, Xiaoxiao Guo, Zhangrui Xu, Jiayi Gao, Wanyu Zhang, Xiaoqin Luo
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Hepatic lipid droplet homeostasis and fatty liver disease
    Fabian Seebacher, Anja Zeigerer, Nora Kory, Natalie Krahmer
    Seminars in Cell & Developmental Biology.2020; 108: 72.     CrossRef
  • Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
    Johanna Matilainen, Anne-Mari Mustonen, Kirsi Rilla, Reijo Käkelä, Sanna P. Sihvo, Petteri Nieminen
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Liver fibrogenesis: un update on established and emerging basic concepts
    Erica Novo, Claudia Bocca, Beatrice Foglia, Francesca Protopapa, Marina Maggiora, Maurizio Parola, Stefania Cannito
    Archives of Biochemistry and Biophysics.2020; 689: 108445.     CrossRef
  • Relative contribution of fat diet and physical inactivity to the development of metabolic syndrome and non-alcoholic fat liver disease in Wistar rats
    Antonio Bovolini, Juliana Garcia, Maria Amparo Andrade, José Alberto Duarte
    Physiology & Behavior.2020; 225: 113040.     CrossRef
  • Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway
    Li Zhang, Hui-Xia Li, Wu-Si Pan, Farhan Ullah Khan, Cheng Qian, Feng-Rong Qi-Li, Xiaojun Xu
    Biomedicine & Pharmacotherapy.2019; 110: 571.     CrossRef
  • Association Between Nonalcoholic Fatty Liver Disease and Future Deterioration of Metabolic Health: A Cohort Study
    You‐Cheol Hwang, Hong‐Yup Ahn, Cheol‐Young Park
    Obesity.2019; 27(8): 1360.     CrossRef
  • Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer
    Hongbo Wang, Zaiming Lu, Xiangxuan Zhao
    Journal of Hematology & Oncology.2019;[Epub]     CrossRef
  • Elastography in the Diagnosis of Non-Alcoholic Fatty Liver Disease
    Elena N. Shirokova, Chavdar S. Pavlov, Anna D. Karaseva, Aliya M. Alieva, Alla V. Sedova, Vladimir T. Ivashkin
    Annals of the Russian academy of medical sciences.2019; 74(1): 5.     CrossRef
  • Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro
    Xiao-qun Han, San-qing Xu, Jian-guo Lin
    Current Medical Science.2019; 39(5): 766.     CrossRef
  • Lipid mediators of liver injury in nonalcoholic fatty liver disease
    Suthat Liangpunsakul, Naga Chalasani
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 316(1): G75.     CrossRef
  • Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
    Maurizio Parola, Massimo Pinzani
    Molecular Aspects of Medicine.2019; 65: 37.     CrossRef
  • Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis
    Lili Nimri, Katerina Staikin, Irena Peri, Einav Yehuda‐Shnaidman, Betty Schwartz
    Journal of Gastroenterology and Hepatology.2018; 33(12): 1990.     CrossRef
  • miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
    Chang-Hai Liu, Javier Ampuero, Antonio Gil-Gómez, Rocío Montero-Vallejo, Ángela Rojas, Rocío Muñoz-Hernández, Rocío Gallego-Durán, Manuel Romero-Gómez
    Journal of Hepatology.2018; 69(6): 1335.     CrossRef
  • Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells
    Jae Min Cha, Eun Kyoung Shin, Ji Hee Sung, Gyeong Joon Moon, Eun Hee Kim, Yeon Hee Cho, Hyung Dal Park, Hojae Bae, Jinseok Kim, Oh Young Bang
    Scientific Reports.2018;[Epub]     CrossRef
  • Changes in the Structure of the Liver during Obesity (Literature Review)
    V. I. Prymachenko
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 4(2): 45.     CrossRef
  • Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease
    Juan Pablo Arab, Marco Arrese, Michael Trauner
    Annual Review of Pathology: Mechanisms of Disease.2018; 13(1): 321.     CrossRef
  • Apoptosis and non-alcoholic fatty liver diseases
    Tatsuo Kanda, Shunichi Matsuoka, Motomi Yamazaki, Toshikatsu Shibata, Kazushige Nirei, Hiroshi Takahashi, Tomohiro Kaneko, Mariko Fujisawa, Teruhisa Higuchi, Hitomi Nakamura, Naoki Matsumoto, Hiroaki Yamagami, Masahiro Ogawa, Hiroo Imazu, Kazumichi Kuroda
    World Journal of Gastroenterology.2018; 24(25): 2661.     CrossRef
  • Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: a novel gut-immune system-based therapy for metaflammation and NASH
    Y Ilan, K Shailubhai, A Sanyal
    Clinical and Experimental Immunology.2018; 193(3): 275.     CrossRef
  • Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice
    Karla Frida Torres Flister, Bruno Araújo Serra Pinto, Lucas Martins França, Caio Fernando Ferreira Coêlho, Pâmela Costa dos Santos, Caroline Castro Vale, Daniela Kajihara, Victor Debbas, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Paes
    The Journal of Nutritional Biochemistry.2018; 62: 155.     CrossRef
  • Blood-Based Novel Biomarkers for Nonalcoholic Steatohepatitis
    Yun Qiu, Sufan Wang, Ting Wan, Mingtong Ye, Rui Jiang, Lei Pei, Lili Yang
    Biomarkers in Medicine.2018; 12(5): 501.     CrossRef
  • The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
    Bojan Jorgačević, Danijela Vučević, Ivana Đuričić, Slađana Šobajić, Dušan Mladenović, Milena Vesković, Rada Ješić Vukićević, Tatjana Radosavljević
    Chemistry and Physics of Lipids.2017; 204: 85.     CrossRef
  • Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition
    Soo Hyun Kim, Gyuri Kim, Dai Hoon Han, Milim Lee, Irene Kim, Bohkyung Kim, Kook Hwan Kim, Young-Mi Song, Jeong Eun Yoo, Hye Jin Wang, Soo Han Bae, Yong-Ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Myung-Shik Lee
    Autophagy.2017; 13(10): 1767.     CrossRef
  • Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status
    Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Seung Hwan Han, Kwang-Hyub Han, Bong-Soo Cha, Choon Hee Chung, Byung-Wan Lee
    Metabolism.2017; 66: 23.     CrossRef
  • Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease
    Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim, Salvatore Petta
    PLOS ONE.2017; 12(7): e0182202.     CrossRef
  • Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation
    Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Susanne Kaser
    PLOS ONE.2017; 12(7): e0180118.     CrossRef
  • Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats
    Xu-Jia Chen, Wen-Jing Liu, Meng-Liang Wen, Hong Liang, Shao-Mei Wu, Yun-Zhen Zhu, Jiang-Yuan Zhao, Xiang-Qian Dong, Ming-Gang Li, Li Bian, Cheng-Gang Zou, Lan-Qing Ma
    Scientific Reports.2017;[Epub]     CrossRef
  • Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH
    Melanie Tran, Sang-Min Lee, Dong-Ju Shin, Li Wang
    JCI Insight.2017;[Epub]     CrossRef
  • Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis
    Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic, Miodrag L Lukic
    World Journal of Gastroenterology.2016; 22(44): 9706.     CrossRef
  • Hepatocyte mitochondrial DNA released in microparticles and toll‐like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis
    Maria Eugenia Inzaugarat, Alexander Wree, Ariel E. Feldstein
    Hepatology.2016; 64(2): 669.     CrossRef
  • Metabolic aspects of adult patients with nonalcoholic fatty liver disease
    Ludovico Abenavoli, Natasa Milic, Laura Di Renzo, Tomislav Preveden, Milica Medić-Stojanoska, Antonino De Lorenzo
    World Journal of Gastroenterology.2016; 22(31): 7006.     CrossRef
  • Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions
    Maria Grazia Clemente, Claudia Mandato, Marco Poeta, Pietro Vajro
    World Journal of Gastroenterology.2016; 22(36): 8078.     CrossRef
  • Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals
    Sabri Rial, Antony Karelis, Karl-F. Bergeron, Catherine Mounier
    Nutrients.2016; 8(5): 281.     CrossRef
Glucolipotoxicity in Pancreatic β-Cells
Ji-Won Kim, Kun-Ho Yoon
Diabetes Metab J. 2011;35(5):444-450.   Published online October 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.5.444
  • 54,718 View
  • 101 Download
  • 59 Crossref
AbstractAbstract PDFPubReader   

The recent epidemic of type 2 diabetes in Asia differs from that reported in other regions of the world in several key areas: it has evolved over a much shorter time, in an earlier stage of life, and in people with lower body mass indices. These phenotypic characteristics of patients strongly suggest that insulin secretory defects may perform a more important function in the development and progression of diabetes. A genetic element clearly underlies β-cell dysfunction and insufficient β-cell mass; however, a number of modifiable factors are also linked to β-cell deterioration, most notably chronic hyperglycemia and elevated free fatty acid (FFA) levels. Neither glucose nor FFAs alone cause clinically meaningful β-cell toxicity, especially in patients with normal or impaired glucose tolerance. Thus the term "glucolipotoxicity" is perhaps more appropriate in describing the phenomenon. Several mechanisms have been proposed to explain glucolipotoxicity-induced β-cell dysfunction and death, but its major factors appear to be depression of key transcription factor gene expression by altered intracellular energy metabolism and oxidative stress. Therefore, stabilization of metabolic changes induced by glucolipotoxicity in β-cells represents a new avenue for the treatment of type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Intravoxel incoherent motion diffusion-weighted imaging of pancreas: Probing evidence of β-cell dysfunction in asymptomatic adults with hyperglycemia in vivo
    Yingying Song, Bo Chen, Kejing Zeng, Kejia Cai, Hui Sun, Deqing Liu, Ping Liu, Gugen Xu, Guihua Jiang
    Magnetic Resonance Imaging.2024; 108: 161.     CrossRef
  • PIMT Controls Insulin Synthesis and Secretion through PDX1
    Rahul Sharma, Sujay K. Maity, Partha Chakrabarti, Madhumohan R. Katika, Satyamoorthy Kapettu, Kishore V. L. Parsa, Parimal Misra
    International Journal of Molecular Sciences.2023; 24(9): 8084.     CrossRef
  • Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells
    Mohamed Asrih, Rodolphe Dusaulcy, Yvan Gosmain, Jacques Philippe, Emmanuel Somm, François R. Jornayvaz, Baeki E. Kang, Yunju Jo, Min Jeong Choi, Hyon-Seung Yi, Dongryeol Ryu, Karim Gariani
    Molecular and Cellular Endocrinology.2022; 541: 111503.     CrossRef
  • Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
    Jasvinder Singh Bhatti, Abhishek Sehrawat, Jayapriya Mishra, Inderpal Singh Sidhu, Umashanker Navik, Naina Khullar, Shashank Kumar, Gurjit Kaur Bhatti, P. Hemachandra Reddy
    Free Radical Biology and Medicine.2022; 184: 114.     CrossRef
  • Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
    Jonnell C. Small, Aidan Joblin-Mills, Kaycee Carbone, Maria Kost-Alimova, Kumiko Ayukawa, Carol Khodier, Vlado Dancik, Paul A. Clemons, Andrew B. Munkacsi, Bridget K. Wagner
    ACS Chemical Biology.2022; 17(5): 1131.     CrossRef
  • Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
    Svetlana Dinić, Jelena Arambašić Jovanović, Aleksandra Uskoković, Mirjana Mihailović, Nevena Grdović, Anja Tolić, Jovana Rajić, Marija Đorđević, Melita Vidaković
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Targeting pancreatic β cells for diabetes treatment
    Chirag Jain, Ansarullah, Sara Bilekova, Heiko Lickert
    Nature Metabolism.2022; 4(9): 1097.     CrossRef
  • The high-fructose intake of dams during pregnancy and lactation exerts sex-specific effects on adult rat offspring metabolism
    Francisca A. Tobar-Bernal, Sergio R. Zamudio, Lucía Quevedo-Corona
    Journal of Developmental Origins of Health and Disease.2021; 12(3): 411.     CrossRef
  • Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies
    Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
    International Journal of Molecular Sciences.2021; 22(10): 5303.     CrossRef
  • A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives
    Josh Reed, Stephen Bain, Venkateswarlu Kanamarlapudi
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 3567.     CrossRef
  • Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2 Diabetes?
    Ana Elena Rodriguez-Rodriguez, Esteban Porrini, Armando Torres
    International Journal of Molecular Sciences.2021; 22(19): 10311.     CrossRef
  • Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis
    Piotr Wójcik, Neven Žarković, Agnieszka Gęgotek, Elżbieta Skrzydlewska
    Biomolecules.2020; 10(3): 402.     CrossRef
  • Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential
    Maria Karmella Apaya, Tien-Fen Kuo, Meng-Ting Yang, Greta Yang, Chiao-Ling Hsiao, Song-Bin Chang, Yenshou Lin, Wen-Chin Yang
    Pharmacological Research.2020; 156: 104754.     CrossRef
  • Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases
    Waihong Chung, Kittichai Promrat, Jack Wands
    World Journal of Hepatology.2020; 12(9): 533.     CrossRef
  • Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos
    Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, Willi
    Cell Reports.2019; 28(3): 759.     CrossRef
  • Metabolic signatures suggest o-phosphocholine to UDP-N-acetylglucosamine ratio as a potential biomarker for high-glucose and/or palmitate exposure in pancreatic β-cells
    Saleem Yousf, Devika M. Sardesai, Abraham B. Mathew, Rashi Khandelwal, Jhankar D. Acharya, Shilpy Sharma, Jeetender Chugh
    Metabolomics.2019;[Epub]     CrossRef
  • Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets
    Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
    Diabetes.2019; 68(10): 1965.     CrossRef
  • Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation
    Hyun-Je Kim, Ji Hwan Moon, Hyunwoo Chung, Jun-Seop Shin, Bongi Kim, Jong-Min Kim, Jung-Sik Kim, Il-Hee Yoon, Byoung-Hoon Min, Seong-Jun Kang, Yong-Hee Kim, Kyuri Jo, Joungmin Choi, Heejoon Chae, Won-Woo Lee, Sun Kim, Chung-Gyu Park
    Scientific Reports.2019;[Epub]     CrossRef
  • Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action
    Miloš Đorđević, Nevena Grdović, Mirjana Mihailović, Jelena Arambašić Jovanović, Aleksandra Uskoković, Jovana Rajić, Marija Sinadinović, Anja Tolić, Danijela Mišić, Branislav Šiler, Goran Poznanović, Melita Vidaković, Svetlana Dinić
    Journal of Ethnopharmacology.2019; 242: 112043.     CrossRef
  • Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis
    Wen Zeng, Jiansong Tang, Haicheng Li, Haixia Xu, Hongyun Lu, Hangya Peng, Chuwen Lin, Rili Gao, Shuo Lin, Keyi Lin, Kunying Liu, Yan Jiang, Jianping Weng, Longyi Zeng
    Cellular Signalling.2018; 47: 65.     CrossRef
  • Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity
    Zonghong Li, Hongyang Liu, Zhangjing Niu, Wen Zhong, Miaomiao Xue, Jifeng Wang, Fuquan Yang, Yue Zhou, Yifa Zhou, Tao Xu, Junjie Hou
    Molecular & Cellular Proteomics.2018; 17(11): 2119.     CrossRef
  • Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass
    Blandine Laferrère, François Pattou
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia
    Aparecida Gabriela Bexiga Veloso, Nathalia Edviges Alves Lima, Elisabete de Marco Ornelas, Clever Gomes Cardoso, Mara Rubia Marques, Beatriz da Costa Aguiar Alves Reis, Fernando Luiz Affonso Fonseca, Laura Beatriz Mesiano Maifrino
    Medical Molecular Morphology.2018; 51(2): 118.     CrossRef
  • Cardiac Glucolipotoxicity and Cardiovascular Outcomes
    Marlon E. Cerf
    Medicina.2018; 54(5): 70.     CrossRef
  • High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant
    Jianhui Liu, Kunimasa Yagi, Atsushi Nohara, Daisuke Chujo, Azusa Ohbatake, Aya Fujimoto, Yukiko Miyamoto, Junji Kobayashi, Masakazu Yamagishi
    Journal of Clinical Lipidology.2018; 12(2): 331.     CrossRef
  • Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven
    Dulce Morales, Guillermo Ramirez, Armando Herrera-Arellano, Jaime Tortoriello, Miguel Zavala, Alejandro Zamilpa
    Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
  • The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response
    Jingqi Fu, Qi Cui, Bei Yang, Yongyong Hou, Huihui Wang, Yuanyuan Xu, Difei Wang, Qiang Zhang, Jingbo Pi
    Food and Chemical Toxicology.2017; 100: 161.     CrossRef
  • Phenolic constituents and modulatory effects of Raffia palm leaf ( Raphia hookeri ) extract on carbohydrate hydrolyzing enzymes linked to type-2 diabetes
    Felix A. Dada, Sunday I. Oyeleye, Opeyemi B. Ogunsuyi, Tosin A. Olasehinde, Stephen A. Adefegha, Ganiyu Oboh, Aline A. Boligon
    Journal of Traditional and Complementary Medicine.2017; 7(4): 494.     CrossRef
  • A gene-environment interaction analysis of plasma selenium with prevalent and incident diabetes: The Hortega study
    Inmaculada Galan-Chilet, Maria Grau-Perez, Griselda De Marco, Eliseo Guallar, Juan Carlos Martin-Escudero, Alejandro Dominguez-Lucas, Isabel Gonzalez-Manzano, Raul Lopez-Izquierdo, Laisa Socorro Briongos-Figuero, Josep Redon, Felipe Javier Chaves, Maria T
    Redox Biology.2017; 12: 798.     CrossRef
  • Differential dose-dependent Effects of Zinc Oxide Nanoparticles on Oxidative stress-mediated Pancreatic β-cell Death
    Swati C Asani, Rinku D Umrani, Kishore M Paknikar
    Nanomedicine.2017; 12(7): 745.     CrossRef
  • Mild hyperglycemia triggered islet function recovery in streptozotocin‐induced insulin‐deficient diabetic rats
    Yu Cheng, Jing Shen, Weizheng Ren, Haojie Hao, Zongyan Xie, Jiejie Liu, Yiming Mu, Weidong Han
    Journal of Diabetes Investigation.2017; 8(1): 44.     CrossRef
  • The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells
    Atsuko Kitahara, Kazuto Takahashi, Naru Morita, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Toshiaki Tanaka, Takuma Kondo, Toshio Hosaka, Hitoshi Ishida
    Marine Drugs.2017; 15(6): 185.     CrossRef
  • Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice
    Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, Margit Mahlapuu
    Journal of Endocrinology.2017; 234(1): 15.     CrossRef
  • Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
    Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
    Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
  • The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
    Ji Sung Yoon, Jun Sung Moon, Yong-Woon Kim, Kyu Chang Won, Hyoung Woo Lee
    Journal of Korean Medical Science.2016; 31(4): 547.     CrossRef
  • The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients
    Chenxiao Liu, Xianjin Ke, Ying Wang, Xiu Feng, Qi Li, Ying Zhang, Jian Zhu, Qian Li
    BMC Endocrine Disorders.2016;[Epub]     CrossRef
  • Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
    Midhat H. Abdulreda, Rayner Rodriguez-Diaz, Alejandro Caicedo, Per-Olof Berggren
    Cell Metabolism.2016; 23(3): 541.     CrossRef
  • Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes
    Purvi C. Trivedi, Jordan J. Bartlett, Lester J. Perez, Keith R. Brunt, Jean Francois Legare, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2016; 1861(12): 1893.     CrossRef
  • Diabetes risk prediction model for non‐obese Asian Indians residing in North India using cut‐off values for pancreatic and intra‐abdominal fat volume and liver span
    Shajith Anoop, Anoop Misra, Kalaivani Mani, Ravindra Mohan Pandey, Seema Gulati
    Journal of Diabetes.2016; 8(5): 729.     CrossRef
  • Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis
    K. Petropoulou, E. S. Chambers, D. J. Morrison, T. Preston, I. F. Godsland, P. Wilde, A. Narbad, R. Parker, L. Salt, V. J. Morris, C. Domoney, S. J. Persaud, E. Holmes, S. Penson, J. Watson, M. Stocks, M. Buurman, M. Luterbacher, G. Frost
    Nutrition Bulletin.2016; 41(4): 372.     CrossRef
  • Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets
    CHENGHU HUANG, LI YUAN, SHUYI CAO
    International Journal of Molecular Medicine.2015; 36(1): 173.     CrossRef
  • Mitochondrien als Kraftwerk der β-Zelle
    S. Baltrusch, F. Reinhardt, M. Tiedge
    Der Diabetologe.2015; 11(3): 231.     CrossRef
  • Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells
    LiLi Gao, Wei Tang, ZhengZheng Ding, DingYu Wang, XiaoQiang Qi, HuiWen Wu, Jun Guo
    Molecular Medicine.2015; 21(1): 154.     CrossRef
  • Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
    Sergio Wehinger, Rina Ortiz, María Inés Díaz, Adam Aguirre, Manuel Valenzuela, Paola Llanos, Christopher Mc Master, Lisette Leyton, Andrew F.G. Quest
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(5): 693.     CrossRef
  • Body Fat Patterning, Hepatic Fat and Pancreatic Volume of Non-Obese Asian Indians with Type 2 Diabetes in North India: A Case-Control Study
    Anoop Misra, Shajith Anoop, Seema Gulati, Kalaivani Mani, Surya Prakash Bhatt, Ravindra Mohan Pandey, Anna Alisi
    PLOS ONE.2015; 10(10): e0140447.     CrossRef
  • CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells
    Udayakumar Karunakaran, Jun Sung Moon, Hyoung Woo Lee, Kyu Chang Won
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(11): 2414.     CrossRef
  • Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1
    Mark F McCarty, James J DiNicolantonio
    Open Heart.2015; 2(1): e000205.     CrossRef
  • Acarbose: safe and effective for lowering postprandial hyperglycaemia and improving cardiovascular outcomes
    James J DiNicolantonio, Jaikrit Bhutani, James H O'Keefe
    Open Heart.2015; 2(1): e000327.     CrossRef
  • P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells
    Lingli Zhou, Xiaoling Cai, Xueyao Han, Linong Ji
    Journal of Diabetes Research.2014; 2014: 1.     CrossRef
  • ImpairedβCell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia
    Yuhang Ma, Yufan Wang, Qianfang Huang, Qian Ren, Su Chen, Aifang Zhang, Li Zhao, Qin Zhen, Yongde Peng
    Journal of Diabetes Research.2014; 2014: 1.     CrossRef
  • Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation
    Ana L. Guadarrama-López, Roxana Valdés-Ramos, Beatríz E. Martínez-Carrillo
    Journal of Immunology Research.2014; 2014: 1.     CrossRef
  • A Comparative Study of the Effects of a Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability in Patients with Type 2 Diabetes with Inadequate Glycemic Control on Metformin
    Hun-Sung Kim, Jeong-Ah Shin, Seung-Hwan Lee, Eun-Sook Kim, Jae-Hyoung Cho, Ho-Young Son, Kun-Ho Yoon
    Diabetes Technology & Therapeutics.2013; 15(10): 810.     CrossRef
  • Localization and regulation of pancreatic selenoprotein P
    Holger Steinbrenner, Anna-Lena Hotze, Bodo Speckmann, Antonio Pinto, Helmut Sies, Matthias Schott, Margret Ehlers, Werner A Scherbaum, Sven Schinner
    Journal of Molecular Endocrinology.2013; 50(1): 31.     CrossRef
  • Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction
    Young Mi Song, Sun Ok Song, Young-Hye You, Kun-Ho Yoon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Ji-Won Kim, Byung-Wan Lee
    Endocrinology.2013; 154(8): 2626.     CrossRef
  • miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models
    J.-W. Kim, Y.-H. You, S. Jung, H. Suh-Kim, I.-K. Lee, J.-H. Cho, K.-H. Yoon
    Diabetologia.2013; 56(4): 847.     CrossRef
  • Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population
    E. M. Brady, D. R. Webb, D. H. Morris, K. Khunti, D. S. C. Talbot, N. Sattar, M. J. Davies
    Experimental Diabetes Research.2012; 2012: 1.     CrossRef
  • Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells
    Yong-Woon Kim, Jun Sung Moon, Ye Jin Seo, So-Young Park, Jong-Yeon Kim, Ji Sung Yoon, In-Kyu Lee, Hyoung Woo Lee, Kyu Chang Won
    Biochemical and Biophysical Research Communications.2012; 420(2): 462.     CrossRef
  • Human Monoclonal Antibodies against Glucagon Receptor Improve Glucose Homeostasis by Suppression of Hepatic Glucose Output in Diet-Induced Obese Mice
    Wook-Dong Kim, Yong-ho Lee, Min-Hee Kim, Sun-Young Jung, Woo-Chan Son, Seon-Joo Yoon, Byung-Wan Lee, Nigel Irwin
    PLoS ONE.2012; 7(12): e50954.     CrossRef
  • Understanding Pancreas Development for β-Cell Repair and Replacement Therapies
    Aurelia Raducanu, Heiko Lickert
    Current Diabetes Reports.2012; 12(5): 481.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer