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Associations between Fatness, Fitness, IGF and IMT among Obese Korean Male Adolescents
Eun Sung Kim, Ji-Hye Park, Mi Kyung Lee, Dong Hoon Lee, Eun Seok Kang, Hyun Chul Lee, Yoonsuk Jekal, Justin Y. Jeon
Diabetes Metab J. 2011;35(6):610-618.   Published online December 26, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.6.610
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  • 44 Download
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents.

Methods

A total of 225 high school males with a mean age of 16.96±0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured.

Results

The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein.

Conclusion

There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.

Citations

Citations to this article as recorded by  
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    Journal of Pediatric Endocrinology and Metabolism.2021; 34(3): 301.     CrossRef
  • Enerji Metabolizması, Obezite ve Hormonlar
    Derya Selda SINAR, Nasuh Evrim ACAR, İrfan YILDIRIM
    Türkiye Spor Bilimleri Dergisi.2020; 4(1): 30.     CrossRef
  • Carotid Intima‐Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass
    Matthew Arnold, Andrew Linden, Robert Clarke, Yu Guo, Huaidong Du, Zheng Bian, Eric Wan, Meng Yang, Liang Wang, Yuexin Chen, Jianwei Chen, Huajun Long, Qijun Gu, Rory Collins, Liming Li, Zhengming Chen, Sarah Parish, Junshi Chen, Jun Lv, Richard Peto, Rob
    Journal of the American Heart Association.2019;[Epub]     CrossRef
  • Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity
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    Sports Medicine.2018; 48(12): 2725.     CrossRef
  • Protein Intake in Infancy and Carotid Intima Media Thickness at 5 Years - A Secondary Analysis from a Randomized Trial
    Dariusz Gruszfeld, Martina Weber, Monika Nowakowska-Rysz, Roman Janas, Rainer Kozlik-Feldmann, Annick Xhonneux, Clotilde Carlier, Enrica Riva, Elvira Verduci, Ricardo Closa-Monasterolo, Joaquin Escribano, Anna Dobrzanska, Berthold Koletzko
    Annals of Nutrition and Metabolism.2015; 66(1): 51.     CrossRef
  • High Prevalence of Cardiometabolic Risk Factors in Hispanic Adolescents: Correlations with Adipocytokines and Markers of Inflammation
    Cynthia M. Pérez, Ana P. Ortiz, Enrique Fuentes-Mattei, Guermarie Velázquez-Torres, Damarys Santiago, Katya Giovannetti, Raúl Bernabe, Mong-Hong Lee, Sai-Ching J. Yeung
    Journal of Immigrant and Minority Health.2014; 16(5): 865.     CrossRef
  • Cross-sectional and longitudinal relation of IGF1 and IGF-binding protein 3 with lipid metabolism
    Marie-Luise Eggert, Henri Wallaschofski, Anne Grotevendt, Matthias Nauck, Henry Völzke, Stefanie Samietz, Nele Friedrich
    European Journal of Endocrinology.2014; 171(1): 9.     CrossRef
  • Association between insulin‐like growth factor‐1, measures of overnutrition and undernutrition and insulin resistance in black adolescents living in the north‐west province, South Africa
    Ramoteme L. Mamabolo, Cristiana Berti, Makama A. Monyeki, H. Salome Kruger
    American Journal of Human Biology.2014; 26(2): 189.     CrossRef
  • Prevalence and trend of dyslipidaemia from 1996 to 2006 among normal and overweight adolescents in Taiwan
    Philip Kuo, Jhu-Ting Syu, Isabel Lin Tzou, Pi-Yun Chen, Hsiu-Yueh Su, Nain-Feng Chu
    BMJ Open.2014; 4(2): e003800.     CrossRef
  • Relationship of serum insulin-like growth factor I (IGF-I) with nutritional status in pediatric patients with malignant diseases—a single Romanian center experience
    Mihaela Ioana Chinceşan, Oana Mărginean, Ana-Maria Pitea, Minodora Dobreanu
    European Journal of Pediatrics.2013; 172(10): 1401.     CrossRef
  • Gene x environment interactions impact endometrial function and the menstrual cycle: PROGINS, life history, anthropometry, and physical activity
    Elizabeth J. Rowe, Toby K. Eisenstein, Joseph Meissler, L. Christie Rockwell
    American Journal of Human Biology.2013; 25(5): 681.     CrossRef
  • Insulin-like growth factor-I (IGF-I) and clinical nutrition
    Callum Livingstone
    Clinical Science.2013; 125(6): 265.     CrossRef
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    Barthelemy Liabaud, David A. Patrick, Jeffrey A. Geller
    The Journal of Arthroplasty.2013; 28(4): 563.     CrossRef
  • The Relationship Between Fitness, BMI and Risk Factors of Metabolic Syndrome Among University Students in Korea
    Dong-il Kim, Ji Young Kim, Mi Kyoung Lee, Hae-Dong Lee, Ji-Won Lee, Justin Y. Jeon
    The Korean Journal of Obesity.2012; 21(2): 99.     CrossRef
  • The Insulin-Like Growth Factor System and Nutritional Assessment
    Callum Livingstone
    Scientifica.2012; 2012: 1.     CrossRef
Role of Activation of NF- B and AP-1 by Oxidative Stress in Atherosclerosis in Diabetic Patients.
Chul Sik Kim, Geun Taek Lee, Jina Park, Min Ho Cho, Joo Young Nam, Jong Suk Park, Dol Mi Kim, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
Korean Diabetes J. 2004;28(4):255-264.   Published online August 1, 2004
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AbstractAbstract PDF
BACKGROUND
The aim of this study was to evaluate the possible role of NF- B activation and AP-1 by oxidative stress in atherosclerosis in diabetic patients by measuring the carotid intima-media thickness, intracellular ROS generation and activation of transcription factors, including nuclear factor-kappa B (NF- B) and activator protein-1 (AP-1). METHODS: Sixty-six patients (28 males, 38 females; age 56.1 13.4 years; duration of diabetes 115.7 83.4 months) with type 2 diabetes mellitus (DM) were selected for this study. The DM patients included in this study were divided into those with a normal carotid intima-media thickness (Group II) and those with an increased intima-media thickness (Group III). 57 healthy controls matched for age and sex with the DM patients (Group I) were randomly selected. Dichlorodifluorescein (DCF)-sensitive intracellular ROS was measured by fluorescent spectrometry. The activities of NF- B and AP-1 in PBMCs were measured by an electrophoretic mobility shift assay. RESULTS: No differences were evident between the groups in terms of gender, age, BMI, blood pressure, total cholesterol, triglyceride, LDL-cholesterol and HDL-cholesterol. Spontaneous and H2O2 (or phorbol-12-myristate-13-acetate, PMA) stimulated ROS were significantly higher in the PBMCs from the DM patients with an increased intima-media thickness (Group III) than in those without (Group II), and were also higher in the control group (Group I). Moreover, the activities of NF- B and AP-1 were significantly higher in Group III than in Groups I or II. CONCLUSION: The present study demonstrates that intracellular ROS generation, and NF- B and AP-1 activation in PBMCs strongly correlates with the carotid artery IMT. These clinical results suggest that increased oxidative stress in PBMCs may play a role in the pathogenesis of atherosclerosis in DM patients .
High Sensitive C-reactive Protein and Carotid Intima Media Thickness in Korean Population.
Dae Jung Kim, Seung Hee Choi, Se Hwa Kim, Sang Su Chung, Chul Woo Ahn, Bong Soo Cha, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee, Kap Bum Huh
Korean Diabetes J. 2003;27(1):49-62.   Published online February 1, 2003
  • 1,018 View
  • 21 Download
AbstractAbstract PDF
BACKGROUND
A chronic inflammatory response is an important component in the development and progression of atherosclerosis. Since the development of the high-sensitive C-reactive protein (hs-CRP) assay, the association between subtle increases in the hs-CRP concentration and the development of atherosclerosis, has recently been reported. In this study, the relationship between hs-CRP, conventional cardiovascular risk factors and carotid intima media thickness (IMT), were investigated, and whether hs-CRP concentrations analyzed to see if it could be used as an independent risk factor, of early subclinical atherosclerosis in apparently healthy subjects. METHODS: This report was conducted as part of the Korean Metabolic Syndrome Study. Of 1,230 individuals having undergone a routine check-up, 849 were selected, based on their medical history of cardiovascular diseases. The hs-CRP was measured by an ELISA method, using human anti-CRP (CRP II Latex X2, Denka Seiken, Japan). RESULTS: The distribution of the hs-CRP concentration was positively skewed, and the hs-CRP levels ranged from 0.10 to 43.7 mg/L (mean 2.06, median 0.77 mg/L). There were significant positive correlations between the hs-CRP and age, BMI, waist, BP, insulin resistance (HOMA-IR) and the TC/HDL-C ratio. From a multiple regression analysis, independent relationships between the hs-CRP and obesity, hypertension, age ( 60 years), current smoking, male and insulin resistance were found. There were positive correlations between the carotid IMT and age, BMI, waist circumference, SBP, DBP, TC, TG, LDL-C, fasting blood glucose, HOMA-IR and hs-CRP, and a negative correlation between the carotid IMT and the HDL-C. From the multiple regression analysis, independent relationships between the carotid IMT and age, SBP, TC/HDLc, HOMA-IR, waist circumference, and DBP also persisted. After adjusting for the conventional risk factors in the multiple regression, there was no longer a significant relationship between the hs-CRP and the carotid IMT. CONCLUSION: There were strong correlations between the hs-CRP and the conventional cardiovascular risk factors, especially with that of obesity. Also, a highly significant association was also found between the hs-CRP and the carotid IMT. However, the hs-CRP, per se, is not a major independent risk factor of early subclinical atherosclerosis in Koreans.

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