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Extracellular Vimentin Alters Energy Metabolism And Induces Adipocyte Hypertrophy
Ji-Hae Park, Soyeon Kwon, Young Mi Park
Diabetes Metab J. 2024;48(2):215-230.   Published online September 26, 2023
DOI: https://doi.org/10.4093/dmj.2022.0332
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Previous studies have reported that oxidative stress contributes to obesity characterized by adipocyte hypertrophy. However, mechanism has not been studied extensively. In the current study, we evaluated role of extracellular vimentin secreted by oxidized low-density lipoprotein (oxLDL) in energy metabolism in adipocytes.
Methods
We treated 3T3-L1-derived adipocytes with oxLDL and measured vimentin which was secreted in the media. We evaluated changes in uptake of glucose and free fatty acid, expression of molecules functioning in energy metabolism, synthesis of adenosine triphosphate (ATP) and lactate, markers for endoplasmic reticulum (ER) stress and autophagy in adipocytes treated with recombinant vimentin.
Results
Adipocytes secreted vimentin in response to oxLDL. Microscopic evaluation revealed that vimentin treatment induced increase in adipocyte size and increase in sizes of intracellular lipid droplets with increased intracellular triglyceride. Adipocytes treated with vimentin showed increased uptake of glucose and free fatty acid with increased expression of plasma membrane glucose transporter type 1 (GLUT1), GLUT4, and CD36. Vimentin treatment increased transcription of GLUT1 and hypoxia-inducible factor 1α (Hif-1α) but decreased GLUT4 transcription. Adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor γ (PPARγ), sterol regulatory element-binding protein 1 (SREBP1), diacylglycerol O-acyltransferase 1 (DGAT1) and 2 were decreased by vimentin treatment. Markers for ER stress were increased and autophagy was impaired in vimentin-treated adipocytes. No change was observed in synthesis of ATP and lactate in the adipocytes treated with vimentin.
Conclusion
We concluded that extracellular vimentin regulates expression of molecules in energy metabolism and promotes adipocyte hypertrophy. Our results show that vimentin functions in the interplay between oxidative stress and metabolism, suggesting a mechanism by which adipocyte hypertrophy is induced in oxidative stress.

Citations

Citations to this article as recorded by  
  • Novel secreted regulators of glucose and lipid metabolism in the development of metabolic diseases
    Lianna W. Wat, Katrin J. Svensson
    Diabetologia.2024;[Epub]     CrossRef
  • Mechanobiology in Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity
    Emily L. Rudolph, LiKang Chin
    Current Issues in Molecular Biology.2024; 46(7): 7134.     CrossRef
  • Context-specific fatty acid uptake is a finely-tuned multi-level effort
    Juan Wang, Huiling Guo, Lang-Fan Zheng, Peng Li, Tong-Jin Zhao
    Trends in Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • The Functions of SARS-CoV-2 Receptors in Diabetes-Related Severe COVID-19
    Adam Drzymała
    International Journal of Molecular Sciences.2024; 25(17): 9635.     CrossRef
Review
Complications
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Treatment of Diabetic Kidney Disease: Current and Future
Tomotaka Yamazaki, Imari Mimura, Tetsuhiro Tanaka, Masaomi Nangaku
Diabetes Metab J. 2021;45(1):11-26.   Published online January 22, 2021
DOI: https://doi.org/10.4093/dmj.2020.0217
  • 24,496 View
  • 1,516 Download
  • 116 Web of Science
  • 120 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However, only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD. In 2019, sodium-glucose cotransporter 2 (SGLT2) inhibitor showed efficacy against DKD in Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, adding a new treatment option. However, the progression of DKD has not been completely controlled. The patients with transient exposure to hyperglycemia develop diabetic complications, including DKD, even after normalization of their blood glucose. Temporary hyperglycemia causes advanced glycation end product (AGE) accumulations and epigenetic changes as metabolic memory. The drugs that improve metabolic memory are awaited, and AGE inhibitors and histone modification inhibitors are the focus of clinical and basic research. In addition, incretin-related drugs showed a renoprotective ability in many clinical trials, and these trials with renal outcome as their primary endpoint are currently ongoing. Hypoxia-inducible factor prolyl hydroxylase inhibitors recently approved for renal anemia may be renoprotective since they improve tubulointerstitial hypoxia. Furthermore, NF-E2–related factor 2 activators improved the glomerular filtration rate of DKD patients in Bardoxolone Methyl Treatment: Renal Function in chronic kidney disease/Type 2 Diabetes (BEAM) trial and Phase II Study of Bardoxolone Methyl in Patients with Chronic Kidney Disease and Type 2 Diabetes (TSUBAKI) trial. Thus, following SGLT2 inhibitor, numerous novel drugs could be utilized in treating DKD. Future studies are expected to provide new insights.

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    Archives of Physiology and Biochemistry.2024; 130(4): 411.     CrossRef
  • Clinical value of serum MMP-3 in chronic kidney disease
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    Clinica Chimica Acta.2024; 553: 117725.     CrossRef
  • β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease
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    American Journal of Physiology-Renal Physiology.2024; 326(1): F20.     CrossRef
  • β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?
    Zhiwen Liu, Zheng Dong
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    Lu-Lu Han, Sheng-Hai Wang, Ming-Yan Yao, Hong Zhou
    World Journal of Diabetes.2024; 15(1): 92.     CrossRef
  • Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway
    Honghong Liu, Jiao Wang, Guanru Yue, Jixiong Xu
    Renal Failure.2024;[Epub]     CrossRef
  • Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis
    Jicui Li, Qiaoyan Guo, Xianping Wei, Yuexin Zhu, Manyu Luo, Ping Luo
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Effects of Qidan Tangshen Granule on diabetic kidney disease in patients with type 2 diabetes
    Hua Yang, Shisi Xia, Yilei Cong, Xinyu Yang, Jie Min, Tengfei Wu
    Diabetes Research and Clinical Practice.2024; 209: 111128.     CrossRef
  • Comparison of conventional mathematical model and machine learning model based on recent advances in mathematical models for predicting diabetic kidney disease
    Yingda Sheng, Caimei Zhang, Jing Huang, Dan Wang, Qian Xiao, Haocheng Zhang, Xiaoqin Ha
    DIGITAL HEALTH.2024;[Epub]     CrossRef
  • Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy
    Yinfeng Chen, Xiaying Wang, Jie Min, Jie Zheng, Xuanli Tang, Xiaoling Zhu, Dongrong Yu, De Jin
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 739.     CrossRef
  • Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway
    Xinwang Zhu, Congxiao Zhang, Linlin Liu, Li Xu, Li Yao
    International Journal of Molecular Medicine.2024;[Epub]     CrossRef
  • Decreased risk of renal cell carcinoma in patients with type 2 diabetes treated with sodium glucose cotransporter‐2 inhibitors
    Chun‐Huei Chiu, Wei‐Yao Wang, Hung‐Yi Chen, Pei‐Lun Liao, Gwo‐Ping Jong, Tsung‐Yuan Yang
    Cancer Science.2024; 115(6): 2059.     CrossRef
  • System biology approaches for systemic diseases: Emphasis on type II diabetes mellitus and allied metabolism
    Mohan Das, Moumita Chakraborty, Promi Das, Sayantan Santra, Abhishek Mukherjee, Sarobi Das, Krisztian Banyai, Souvik Roy, Lopamudra Choudhury, Rudrak Gupta, Tama Dey, Dibya Das, Anirbandeep Bose, Balasubramanian Ganesh, Rintu Banerjee
    Biocatalysis and Agricultural Biotechnology.2024; 58: 103176.     CrossRef
  • Two-Dimensional Ultrasound-Based Radiomics Nomogram for Diabetic Kidney Disease: A Pilot Study
    Xingyue Huang, Yugang Hu, Yao Zhang, Qing Zhou
    International Journal of General Medicine.2024; Volume 17: 1877.     CrossRef
  • Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment
    Zhang Ye, Wendy C. Sheu, Huan Qu, Bin Peng, Jia Liu, Li Zhang, Fanen Yuan, Yuxin Wei, Jiangbing Zhou, Qianxue Chen, Xuan Xiao, Shenqi Zhang
    Small Science.2024;[Epub]     CrossRef
  • Diabetic Nephropathy as a Result of Uncontrolled Hyperglycemia
    Camila Silva de Aquino, Estênio Gabriel Miranda, Francisco José Pascoal Ribeiro Júnior, Hérika Juliana de Araújo Lucena, Jéssica Pará Amaral de Oliveira, João Ferreira Lima Neto, Lênio Airam de Pinho, Miguel Valentim Rodrigues, Pedro Henrique Borges Silve
    Revista de Gestão Social e Ambiental.2024; 18(1): e07716.     CrossRef
  • Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy
    Bin Zhang, Changkai Bu, Qingchi Wang, Qingqing Chen, Deling Shi, Hongyan Qiu, Zhangjie Wang, Jian Liu, Zhe Wang, Qunye Zhang, Lianli Chi
    Journal of Biological Chemistry.2024; 300(8): 107493.     CrossRef
  • In Silico Investigation against Inhibitors of Alpha-Amylase Using Structure-based Screening, Molecular Docking, and Molecular Simulations Studies
    Fariya Khan, Altaf Ahmad Shah, Ajay Kumar, Salman Akhtar
    Cell Biochemistry and Biophysics.2024; 82(3): 2873.     CrossRef
  • Associations between Anemia and Glomerular Filtration Rate and Albuminuria in Korean Adults by Metabolic Syndrome Status: Analysis of KNHNES V-3 Data
    Hyun YOON
    Korean Journal of Clinical Laboratory Science.2024; 56(2): 125.     CrossRef
  • Urine biomarkers in type 2 diabetes mellitus with or without microvascular complications
    Chanyuan Zhang, Tiebing Liu, Xiaoqian Wang, Jing Yang, Dongfang Qin, Yin Liang, Xuejing Wang
    Nutrition & Diabetes.2024;[Epub]     CrossRef
  • Quercetin‐4′‐O‐β‐D‐glucopyranoside inhibits podocyte injury by SIRT5‐mediated desuccinylation of NEK7
    Menghua Wu, Xiaoli Ye
    Clinical and Experimental Pharmacology and Physiology.2024;[Epub]     CrossRef
  • Mesenchymal stem cell-derived exosomes ameliorate diabetic kidney disease through NOD2 signaling pathway
    Yinghui Wang, Donglin Lu, Shasha Lv, Xiangchun Liu, Gang Liu
    Renal Failure.2024;[Epub]     CrossRef
  • Real-World Clinical Effectiveness of Glucagon-Like Peptide-1 Receptor Agonist on Mild-to-Moderate Diabetic Kidney Disease in Patients with Type 2 Diabetes: A Retrospective, Single-Arm Clinical Trial
    Yongsheng Cao, Jianqin Zhao, Yanjuan Ma, Shujie Cao, Ying Liu
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2913.     CrossRef
  • Single-cell RNA sequencing in diabetic kidney disease: a literature review
    Wei Tan, Jiaoyan Chen, Yunyan Wang, Kui Xiang, Xianqiong Lu, Qiuyu Han, Mingyue Hou, Jurong Yang
    Renal Failure.2024;[Epub]     CrossRef
  • Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetic kidney disease in mice via inhibiting the SGLT2/glycolysis pathway
    Ziyang Lin, Hongyan Huo, Minyi Huang, Jie Tao, Yiqi Yang, Jiao Guo
    Journal of Ethnopharmacology.2024; 335: 118698.     CrossRef
  • Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets
    Suye Zhong, Na Wang, Chun Zhang
    International Journal of Molecular Sciences.2024; 25(16): 9035.     CrossRef
  • Astragaloside IV attenuates fatty acid-induced renal tubular injury in diabetic kidney disease by inhibiting fatty acid transport protein-2
    Jing Wang, Lingchen Wang, Xiaoxuan Feng, Yizeng Xu, Liang Zhou, Chen Wang, Meng Wang
    Phytomedicine.2024; 134: 155991.     CrossRef
  • Deciphering interleukin‐18 in diabetes and its complications: Biological features, mechanisms, and therapeutic perspectives
    Runlin Gui, Yuanyuan Ren, Zhen Wang, Yang Li, Chengsong Wu, Xiaofang Li, Man Li, Yujia Li, Lu Qian, Yuyan Xiong
    Obesity Reviews.2024;[Epub]     CrossRef
  • Cardiovascular autonomic neuropathy and the risk of diabetic kidney disease
    Injeong Cho, Seohyun Lim, Minjae Kwon, Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Molecular Therapeutics for Diabetic Kidney Disease: An Update
    Man Guo, Fangfang He, Chun Zhang
    International Journal of Molecular Sciences.2024; 25(18): 10051.     CrossRef
  • Effect of GLP-1 Receptor Agonists on Renal Functions and Diabetic Nephropathy in Type 2 Diabetes Mellitus (T2DM) Patients: A Systematic Review and Meta-Analysis
    Ali J Mohamed, Ali H AlSaffar, Ali A Mohamed , Mohamed H Khamis, Ahmed A Khalaf, Husain J AlAradi, Abdulla I Abuhamaid, Ali H Sanad, Hasan L Abbas, Abdulla M Abdulla, Osama A Alkhamis
    Cureus.2024;[Epub]     CrossRef
  • Radish red protects against early diabetic kidney disease through inhibiting inflammation, pyroptosis and insulin resistance via IRAK1 signaling suppression
    Qiang Li, Yanbin Zheng, Jianyu Zhao, Xinyi Wei, Zongxin Shi, Haonan Fan, Chenxu Ge, Minxuan Xu, Jun Tan
    Journal of Functional Foods.2024; 122: 106470.     CrossRef
  • New insights on genetic background of major diabetic vascular complications
    Zuira Tariq, Salah Abusnana, Bashair M. Mussa, Hala Zakaria
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
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    Biernat Paweł, Radosław Balwierz, Dyliński Mieszko, Kołacki Mikołaj, Ewa Micewicz, Bursy Dawid, Łukasz Pogorzelec
    Scientific Reports.2024;[Epub]     CrossRef
  • Crosstalk of Hyperglycaemia and Cellular Mechanisms in the Pathogenesis of Diabetic Kidney Disease
    Esienanwan Esien Efiong, Homa Bazireh, Markéta Fuchs, Peter Uchenna Amadi, Emmanuel Effa, Sapna Sharma, Christoph Schmaderer
    International Journal of Molecular Sciences.2024; 25(20): 10882.     CrossRef
  • A mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy
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    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulations Reveal the Mechanisms of Cinnamomum tamala in Diabetic Nephropathy Treatment: An In Silico Study
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    Current Issues in Molecular Biology.2024; 46(11): 11868.     CrossRef
  • Exercise as a therapeutic approach to alleviate diabetic kidney disease: mechanisms, clinical evidence and potential exercise prescriptions
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    Xiaofeng Liu, Yuwei Huang, Xianchen Zhao, Yingjun Guan, Yanchun Li, Lei Yuan, Chuncheng Wang, Chao Ma, Enlong Ma
    Bioorganic Chemistry.2024; 153: 107961.     CrossRef
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    Journal of Diabetes Investigation.2024;[Epub]     CrossRef
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    Journal of Diabetes Research.2024;[Epub]     CrossRef
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    Journal of Ethnopharmacology.2023; 302: 115860.     CrossRef
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    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 585.     CrossRef
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    Pharmacological Research - Modern Chinese Medicine.2023; 6: 100216.     CrossRef
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    Biochemical and Biophysical Research Communications.2023; 648: 50.     CrossRef
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  • Hypoxia-Inducible Factor-Prolyl-Hydroxylase and Sodium-Glucose Cotransporter 2 Inhibitors for Low-Risk Myelodysplastic Syndrome-Related Anemia in Patients with Chronic Kidney Disease: A Report of Three Cases
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    Hematology Reports.2023; 15(1): 180.     CrossRef
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    Journal of Medical Biochemistry.2023; 42(2): 239.     CrossRef
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    Physiological Reports.2023;[Epub]     CrossRef
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    Analytical Chemistry.2023; 95(39): 14762.     CrossRef
  • From normal population to prediabetes and diabetes: study of influencing factors and prediction models
    Di Gong, Xiaohong Chen, Lin Yang, Yongjian Zhang, Qianqian Zhong, Jing Liu, Chen Yan, Yongjiang Cai, Weihua Yang, Jiantao Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetes Monitoring through Urine Analysis Using ATR-FTIR Spectroscopy and Machine Learning
    Sajid Farooq, Denise Maria Zezell
    Chemosensors.2023; 11(11): 565.     CrossRef
  • Treatment and practical considerations of diabetic kidney disease
    Yara Bilen, Allaa Almoushref, Kenda Alkwatli, Omar Osman, Ali Mehdi, Hanny Sawaf
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment
    Jing Li, Na Zhu, Yaqiong Wang, Yanlei Bao, Feng Xu, Fengjuan Liu, Xuefeng Zhou
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 4269.     CrossRef
  • Cardiovascular autonomic neuropathy and incident diabetic kidney disease in patients with type 2 diabetes
    Ji Eun Jun, Min Sun Choi, Jae Hyeon Kim
    Diabetes Research and Clinical Practice.2022; 184: 109181.     CrossRef
  • Lipidomic Analysis Reveals the Protection Mechanism of GLP-1 Analogue Dulaglutide on High-Fat Diet-Induced Chronic Kidney Disease in Mice
    Martin Ho Yin Yeung, Ka Long Leung, Lai Yuen Choi, Jung Sun Yoo, Susan Yung, Pui-Kin So, Chi-Ming Wong
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions
    Ji Hee Yu, So Young Park, Da Young Lee, Nan Hee Kim, Ji A Seo
    Kidney Research and Clinical Practice.2022; 41(2): 136.     CrossRef
  • Evolving Type 2 diabetes management focuses on clinical outcomes
    Caroline Fenton, Connie Kang
    Drugs & Therapy Perspectives.2022; 38(4): 165.     CrossRef
  • Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease
    Chan-Young Jung, Tae-Hyun Yoo
    Diabetes & Metabolism Journal.2022; 46(2): 181.     CrossRef
  • Critical shear stress of red blood cells as a novel integrated biomarker for screening chronic kidney diseases in cases of type 2 diabetes
    Il Rae Park, Jimi Choi, Eun Young Ha, Seung Min Chung, Jun Sung Moon, Sehyun Shin, Sin Gon Kim, Kyu Chang Won
    Clinical Hemorheology and Microcirculation.2022; 81(4): 293.     CrossRef
  • Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
    Donghee Kim, Ga-Young Nam, Eunhui Seo, Hee-Sook Jun
    Journal of Biomedical Science.2022;[Epub]     CrossRef
  • The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1
    Yuji Oe, Volker Vallon
    Kidney and Dialysis.2022; 2(2): 349.     CrossRef
  • Dapagliflozin for the treatment of chronic kidney disease
    Yu Kurata, Masaomi Nangaku
    Expert Review of Endocrinology & Metabolism.2022; 17(4): 275.     CrossRef
  • Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease
    Javier Donate-Correa, María Dolores Sanchez-Niño, Ainhoa González-Luis, Carla Ferri, Alberto Martín-Olivera, Ernesto Martín-Núñez, Beatriz Fernandez-Fernandez, Víctor G Tagua, Carmen Mora-Fernández, Alberto Ortiz, Juan F Navarro-González
    Clinical Kidney Journal.2022; 15(12): 2200.     CrossRef
  • Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
    Debra Dorotea, Songling Jiang, Eun Seon Pak, Jung Beom Son, Hwan Geun Choi, Sung-Min Ahn, Hunjoo Ha
    Experimental & Molecular Medicine.2022; 54(8): 1086.     CrossRef
  • Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics
    Nam Hoon Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(4): 543.     CrossRef
  • Effect of once-weekly dulaglutide on renal function in patients with chronic kidney disease
    Sungmin Kim, Jung Nam An, Young Rim Song, Sung Gyun Kim, Hyung Seok Lee, AJin Cho, Jwa-Kyung Kim, Tomislav Bulum
    PLOS ONE.2022; 17(8): e0273004.     CrossRef
  • Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives
    Daniela Maria Tanase, Evelina Maria Gosav, Madalina Ioana Anton, Mariana Floria, Petronela Nicoleta Seritean Isac, Loredana Liliana Hurjui, Claudia Cristina Tarniceriu, Claudia Florida Costea, Manuela Ciocoiu, Ciprian Rezus
    Biomolecules.2022; 12(9): 1227.     CrossRef
  • Preventive and healing effect of high dosing grape seed flour on CKD patients of various stages and aetiologies
    Wiem Bejaoui, Mohamed Mahmoudi, Kamel Charradi, Monia Abbes-Belhadj, Habib Boukhalfa, Mossadok Ben-Attia, Ferid Limam, Ezzedine Aouani
    Biomarkers.2022; 27(8): 795.     CrossRef
  • Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics
    Miyesaier Abudureyimu, Xuanming Luo, Xiang Wang, James R Sowers, Wenshuo Wang, Junbo Ge, Jun Ren, Yingmei Zhang, Wei-Ping Jia
    Journal of Molecular Cell Biology.2022;[Epub]     CrossRef
  • Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases
    Wei Huang, Yi-Yuan Chen, Zi-Qi Li, Fang-Fang He, Chun Zhang
    International Journal of Molecular Sciences.2022; 23(18): 10882.     CrossRef
  • Serum isthmin-1 levels are positively and independently correlated with albuminuria in patients with type 2 diabetes mellitus
    Chuan Wang, Mingyue Xu, Ruiying Feng, Lei Zhang, Xiaofei Yin, Ruoqi Feng, Kai Liang, Jinbo Liu
    BMJ Open Diabetes Research & Care.2022; 10(5): e002972.     CrossRef
  • hucMSC-sEVs-Derived 14-3-3ζ Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease
    Siqi Yin, Wanzhu Liu, Cheng Ji, Yuan Zhu, Yunjie Shan, Zixuan Zhou, Wenya Chen, Leilei Zhang, Zixuan Sun, Wenqin Zhou, Hui Qian, Chaoliang Tang
    Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
  • Adenosine receptors as emerging therapeutic targets for diabetic kidney disease
    Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha
    Kidney Research and Clinical Practice.2022; 41(Suppl 2): S74.     CrossRef
  • REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
    Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
    Diabetes.2022; 71(11): 2412.     CrossRef
  • The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease
    Huixia Liu, Yujuan Li, Jing Xiong
    Molecules.2022; 27(21): 7318.     CrossRef
  • Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease
    Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson
    Nutrients.2022; 14(21): 4547.     CrossRef
  • Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice
    Yan Yuan, Yuanxia Liu, Mengyao Sun, Huijing Ye, Yuchen Feng, Zhenzhen Liu, Lingyu Pan, Hongbo Weng
    Open Life Sciences.2022; 17(1): 1451.     CrossRef
  • Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
    Jessica L. Davis, Ciaran Kennedy, Shane Clerkin, Niall J. Treacy, Thomas Dodd, Catherine Moss, Alison Murphy, Derek P. Brazil, Gerard Cagney, Dermot F. Brougham, Rabi Murad, Darren Finlay, Kristiina Vuori, John Crean
    Communications Biology.2022;[Epub]     CrossRef
  • Oxidized Albumin: Evaluation of Oxidative Stress as a Marker for the Progression of Kidney Disease
    Hiroshi Watanabe
    Biological and Pharmaceutical Bulletin.2022; 45(12): 1728.     CrossRef
  • Whether Renal Pathology Is an Independent Predictor for End-Stage Renal Disease in Diabetic Kidney Disease Patients with Nephrotic Range Proteinuria: A Biopsy-Based Study
    Tingli Wang, Junlin Zhang, Yiting Wang, Lijun Zhao, Yucheng Wu, Honghong Ren, Yutong Zou, Rui Zhang, Huan Xu, Zhonglin Chai, Mark Cooper, Jie Zhang, Fang Liu
    Journal of Clinical Medicine.2022; 12(1): 88.     CrossRef
  • What’s New in the Molecular Mechanisms of Diabetic Kidney Disease: Recent Advances
    Kimio Watanabe, Emiko Sato, Eikan Mishima, Mariko Miyazaki, Tetsuhiro Tanaka
    International Journal of Molecular Sciences.2022; 24(1): 570.     CrossRef
  • Clinical efficacy and safety of astragalus injection combined with ACEI/ARB in the treatment of diabetic kidney disease: Protocol for a systematic review and meta-analysis
    Zhiyue Zhu, Qi Zhang, Le Liu, Pengjie Bao, Shilin Liu, Chaoqun Song, Wenbo Yang, Zheng Nan
    Medicine.2022; 101(49): e31490.     CrossRef
  • Cudrania tricuspidata Root Extract Prevents Methylglyoxal‐Induced Inflammation and Oxidative Stress via Regulation of the PKC‐NOX4 Pathway in Human Kidney Cells
    Donghee Kim, Jayeon Cheon, Haelim Yoon, Hee-Sook Jun, Evangelia Dounousi
    Oxidative Medicine and Cellular Longevity.2021;[Epub]     CrossRef
  • Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control
    Tomoaki Takata, Hajime Isomoto
    International Journal of Molecular Sciences.2021; 22(9): 4374.     CrossRef
  • HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
    Kiichi Hirota
    Biomedicines.2021; 9(5): 468.     CrossRef
  • Nephropathie bei Diabetes
    Roland E. Schmieder
    CardioVasc.2021; 21(3): 31.     CrossRef
  • Clinical Predictors of Nondiabetic Kidney Disease in Patients with Diabetes: A Single-Center Study
    Francesco Fontana, Rossella Perrone, Francesco Giaroni, Gaetano Alfano, Silvia Giovanella, Giulia Ligabue, Riccardo Magistroni, Gianni Cappelli, Udeme Ekrikpo
    International Journal of Nephrology.2021; 2021: 1.     CrossRef
  • Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
    Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea
    Antioxidants.2021; 10(9): 1356.     CrossRef
  • Plasma and urine biomarkers in chronic kidney disease: closer to clinical application
    Azadeh Zabetian, Steven G. Coca
    Current Opinion in Nephrology & Hypertension.2021; 30(6): 531.     CrossRef
  • Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy
    Fanrui Meng, Yukai Cao, Mir Hassan Khoso, Kai Kang, Guiping Ren, Wei Xiao, Deshan Li
    Archives of Biochemistry and Biophysics.2021; 713: 109063.     CrossRef
  • Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease
    Daiji Kawanami, Yuichi Takashi, Yoshimi Muta, Naoki Oda, Dai Nagata, Hiroyuki Takahashi, Makito Tanabe
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules
    Aleksandra Owczarek, Katarzyna B. Gieczewska, Robert Jarzyna, Zuzanna Frydzinska, Katarzyna Winiarska
    International Journal of Molecular Sciences.2021; 22(24): 13299.     CrossRef
  • The effect of modern hypoglycemic therapy on the course of chronic kidney disease in patients with type 2 diabetes mellitus
    V.I. Katerenchuk
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2021; 17(8): 624.     CrossRef
Original Articles
Basic Research
Article image
Hypoxia Increases β-Cell Death by Activating Pancreatic Stellate Cells within the Islet
Jong Jin Kim, Esder Lee, Gyeong Ryul Ryu, Seung-Hyun Ko, Yu-Bae Ahn, Ki-Ho Song
Diabetes Metab J. 2020;44(6):919-927.   Published online May 11, 2020
DOI: https://doi.org/10.4093/dmj.2019.0181
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AbstractAbstract PDFPubReader   ePub   
Background

Hypoxia can occur in pancreatic islets in type 2 diabetes mellitus. Pancreatic stellate cells (PSCs) are activated during hypoxia. Here we aimed to investigate whether PSCs within the islet are also activated in hypoxia, causing β-cell injury.

Methods

Islet and primary PSCs were isolated from Sprague Dawley rats, and cultured in normoxia (21% O2) or hypoxia (1% O2). The expression of α-smooth muscle actin (α-SMA), as measured by immunostaining and Western blotting, was used as a marker of PSC activation. Conditioned media (hypoxia-CM) were obtained from PSCs cultured in hypoxia.

Results

Islets and PSCs cultured in hypoxia exhibited higher expressions of α-SMA than did those cultured in normoxia. Hypoxia increased the production of reactive oxygen species. The addition of N-acetyl-L-cysteine, an antioxidant, attenuated the hypoxia-induced PSC activation in islets and PSCs. Islets cultured in hypoxia-CM showed a decrease in cell viability and an increase in apoptosis.

Conclusion

PSCs within the islet are activated in hypoxia through oxidative stress and promote islet cell death, suggesting that hypoxia-induced PSC activation may contribute to β-cell loss in type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Effects of hypoxia in the diabetic corneal stroma microenvironment
    Purnima Sharma, Jian-Xing Ma, Dimitrios Karamichos
    Experimental Eye Research.2024; 240: 109790.     CrossRef
  • High‐resolution magic angle spinning nuclear magnetic resonance of donor pancreatic tissue may predict islet viability prior to isolation
    Carolyn M. Slupsky, Brian D. Sykes, Jonathan R. T. Lakey
    NMR in Biomedicine.2024;[Epub]     CrossRef
  • Nanomedicine regulating PSC-mediated intercellular crosstalk: Mechanisms and therapeutic strategies
    Hui Wang, Liang Qi, Han Han, Xuena Li, Mengmeng Han, Lei Xing, Ling Li, Hulin Jiang
    Acta Pharmaceutica Sinica B.2024;[Epub]     CrossRef
  • Visualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient
    Kai Duan, Mengyang Zhou, Yong Wang, Jose Oberholzer, Joe F. Lo
    Microsystems & Nanoengineering.2023;[Epub]     CrossRef
  • Pancreatic stellate cells promote pancreatic β-cell death through exosomal microRNA transfer in hypoxia
    Esder Lee, Gyeong Ryul Ryu, Seung-Hyun Ko, Yu-Bae Ahn, Ki-Ho Song
    Molecular and Cellular Endocrinology.2023; 572: 111947.     CrossRef
  • Pancreatic stellate cells in pancreatic cancer: as potential targets for future therapy
    Zhengfeng Wang, Ru He, Shi Dong, Wence Zhou
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Recent advances in the development of bioartificial pancreas using 3D bioprinting for the treatment of type 1 diabetes: a review
    Anushikha Ghosh, Arka Sanyal, Abhik Mallick
    Exploration of Medicine.2023; : 886.     CrossRef
  • Pancreas and islet morphology in cystic fibrosis: clues to the etiology of cystic fibrosis-related diabetes
    Sarah S. Malik, Diksha Padmanabhan, Rebecca L. Hull-Meichle
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetic mellitus, vascular calcification and hypoxia: A complex and neglected tripartite relationship
    Xue-Jiao Sun, Nai-Feng Liu
    Cellular Signalling.2022; 91: 110219.     CrossRef
  • HIF-1 and NRF2; Key Molecules for Malignant Phenotypes of Pancreatic Cancer
    Shin Hamada, Ryotaro Matsumoto, Atsushi Masamune
    Cancers.2022; 14(2): 411.     CrossRef
  • Pancreatic Stellate Cells and Metabolic Alteration: Physiology and Pathophysiology
    Shin Hamada, Ryotaro Matsumoto, Atsushi Masamune
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Exosomal miR-140–3p and miR-143–3p from TGF-β1-treated pancreatic stellate cells target BCL2 mRNA to increase β-cell apoptosis
    Xiangyun Zhu, Dechen Liu, Guoqing Li, Mengmeng Zhi, Ji Sun, Liang Qi, Jingbo Li, Stephen J. Pandol, Ling Li
    Molecular and Cellular Endocrinology.2022; 551: 111653.     CrossRef
  • Mitochondria oxidative stress mediated nicotine-promoted activation of pancreatic stellate cells by regulating mitochondrial dynamics
    Yue Yuan, Zhiren Li, Miaomiao Li, Tong Jin, Xiaoyun Zhang, Xinjuan Liu, Jianyu Hao
    Toxicology in Vitro.2022; 84: 105436.     CrossRef
  • Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects
    Miaomiao Li, Yue Yuan, Xue Han, Xinjuan Liu, Weizhen Zhang, Jianyu Hao
    Journal of Inflammation Research.2022; Volume 15: 4409.     CrossRef
  • Diabetic Ferroptosis and Pancreatic Cancer: Foe or Friend?
    Le Li, Xing-jia Yu, Lei Gao, Long Cheng, Bei Sun, Gang Wang
    Antioxidants & Redox Signaling.2022; 37(16-18): 1206.     CrossRef
  • Melatonin Induces Apoptosis and Modulates Cyclin Expression and MAPK Phosphorylation in Pancreatic Stellate Cells Subjected to Hypoxia
    Matias Estaras, Manuel R. Gonzalez-Portillo, Miguel Fernandez-Bermejo, Jose M. Mateos, Daniel Vara, Gerardo Blanco-Fernandez, Diego Lopez-Guerra, Vicente Roncero, Gines M. Salido, Antonio González
    International Journal of Molecular Sciences.2021; 22(11): 5555.     CrossRef
  • Integrated pancreatic microcirculatory profiles of streptozotocin‐induced and insulin‐administrated type 1 diabetes mellitus
    Yuan Li, Bingwei Li, Bing Wang, Mingming Liu, Xiaoyan Zhang, Ailing Li, Jian Zhang, Honggang Zhang, Ruijuan Xiu
    Microcirculation.2021;[Epub]     CrossRef
  • Pancreatic stellate cells - rising stars in pancreatic pathologies
    P Hrabák, M Kalousová, T Krechler, T Zima
    Physiological Research.2021; (S4): S597.     CrossRef
Pathophysiology
Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice
Yan Wang, Mary Yuk Kwan Lee, Judith Choi Wo Mak, Mary Sau Man Ip
Diabetes Metab J. 2019;43(5):659-674.   Published online April 23, 2019
DOI: https://doi.org/10.4093/dmj.2018.0196
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

The relationship between obstructive sleep apnoea (OSA) and metabolic disorders is complex and highly associated. The impairment of adipogenic capacity in pre-adipocytes may promote adipocyte hypertrophy and increase the risk of further metabolic dysfunction. We hypothesize that intermittent hypoxia (IH), as a pathophysiologic feature of OSA, may regulate adipogenesis by promoting macrophage polarization.

Methods

Male C57BL/6N mice were exposed to either IH (240 seconds of 10% O2 followed by 120 seconds of 21% O2, i.e., 10 cycles/hour) or intermittent normoxia (IN) for 6 weeks. Stromal-vascular fractions derived from subcutaneous (SUB-SVF) and visceral (VIS-SVF) adipose tissues were cultured and differentiated. Conditioned media from cultured RAW 264.7 macrophages after air (Raw) or IH exposure (Raw-IH) were incubated with SUB-SVF during adipogenic differentiation.

Results

Adipogenic differentiation of SUB-SVF but not VIS-SVF from IH-exposed mice was significantly downregulated in comparison with that derived from IN-exposed mice. IH-exposed mice compared to IN-exposed mice showed induction of hypertrophic adipocytes and increased preferential infiltration of M1 macrophages in subcutaneous adipose tissue (SAT) compared to visceral adipose tissue. Complementary in vitro analysis demonstrated that Raw-IH media significantly enhanced inhibition of adipogenesis of SUB-SVF compared to Raw media, in agreement with corresponding gene expression levels of differentiation-associated markers and adipogenic transcription factors.

Conclusion

Low frequency IH exposure impaired adipogenesis of SAT in lean mice, and macrophage polarization may be a potential mechanism for the impaired adipogenesis.

Citations

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  • Obstructive sleep apnea hypopnea syndrome and vascular lesions: An update on what we currently know
    Zhenyu Mao, Pengdou Zheng, Xiaoyan Zhu, Lingling Wang, Fengqin Zhang, Huiguo Liu, Hai Li, Ling Zhou, Wei Liu
    Sleep Medicine.2024; 119: 296.     CrossRef
  • Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice
    Xinyi Li, Fan Wang, Zhenfei Gao, Weijun Huang, Xiaoman Zhang, Feng Liu, Hongliang Yi, Jian Guan, Xiaolin Wu, Huajun Xu, Shankai Yin
    Microbiological Research.2023; 276: 127480.     CrossRef
  • Clinical outcomes and plaque characteristics in patients with coronary artery disease and concomitant sleep-disordered breathing treated by continuous positive airway pressure
    Kazuhiro Fujiyoshi, Taiki Tojo, Yoshiyasu Minami, Kohki Ishida, Miwa Ishida, Ken-ichiro Wakabayashi, Takayuki Inomata, Junya Ako
    Sleep Medicine.2023; 101: 543.     CrossRef
  • Potential Pathophysiological Pathways in the Complex Relationships between OSA and Cancer
    Manuel Sánchez-de-la-Torre, Carolina Cubillos, Olivia J. Veatch, Francisco Garcia-Rio, David Gozal, Miguel Angel Martinez-Garcia
    Cancers.2023; 15(4): 1061.     CrossRef
  • Effects of Chronic Intermittent Hypoxia and Chronic Sleep Fragmentation on Gut Microbiome, Serum Metabolome, Liver and Adipose Tissue Morphology
    Fan Wang, Juanjuan Zou, Huajun Xu, Weijun Huang, Xiaoman Zhang, Zhicheng Wei, Xinyi Li, Yupu Liu, Jianyin Zou, Feng Liu, Huaming Zhu, Hongliang Yi, Jian Guan, Shankai Yin
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • C‐X3‐C motif chemokine ligand 1/receptor 1 regulates the M1 polarization and chemotaxis of macrophages after hypoxia/reoxygenation injury
    Shuiming Guo, Lei Dong, Junhua Li, Yuetao Chen, Ying Yao, Rui Zeng, Nelli Shushakova, Hermann Haller, Gang Xu, Song Rong
    Chronic Diseases and Translational Medicine.2021; 7(4): 254.     CrossRef
Sulwon Lecture 2018
Pathophysiology
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Chang-Yun Woo, Jung Eun Jang, Seung Eun Lee, Eun Hee Koh, Ki-Up Lee
Diabetes Metab J. 2019;43(3):247-256.   Published online March 27, 2019
DOI: https://doi.org/10.4093/dmj.2018.0221
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AbstractAbstract PDFPubReader   

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation.

Citations

Citations to this article as recorded by  
  • Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat–High-Sucrose Diet in a Rat Model
    Nada Abughazaleh, Kevin Boldt, Jaqueline Lourdes Rios, Stela Marcia Mattiello, Kelsey H. Collins, Ruth-Anne Seerattan, Walter Herzog
    CARTILAGE.2024; 15(4): 453.     CrossRef
  • Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men
    Ronni Eg Sahl, Ioanna Patsi, Mikkel Thunestvedt Hansen, Tue Rømer, Jacob Frandsen, Hanne Kruuse Rasmusen, Arthur Ingersen, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Jørn Wulff Helge
    The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e799.     CrossRef
  • Diabetes Mellitus, Energy Metabolism, and COVID-19
    Caterina Conte, Elisa Cipponeri, Michael Roden
    Endocrine Reviews.2024; 45(2): 281.     CrossRef
  • The Role of Ion-Transporting Proteins in Human Disease
    Yoshinori Marunaka
    International Journal of Molecular Sciences.2024; 25(3): 1726.     CrossRef
  • The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
    Preethi Chandrasekaran, Ralf Weiskirchen
    International Journal of Molecular Sciences.2024; 25(3): 1882.     CrossRef
  • The Metabolic Syndrome, a Human Disease
    Marià Alemany
    International Journal of Molecular Sciences.2024; 25(4): 2251.     CrossRef
  • Inflammation‐mediated metabolic regulation in adipose tissue
    Shujie Xu, Feng Lu, Jianhua Gao, Yi Yuan
    Obesity Reviews.2024;[Epub]     CrossRef
  • Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial Dysfunction Associated with Metabolic Syndrome
    Micaela M. Rossi, Franco J. Signorini, Tomas A. Castillo, María P. Scribano Parada, Federico Moser, Maria dC Baez
    Obesity Surgery.2024; 34(6): 2042.     CrossRef
  • The relationships between high-fat diet and metabolic syndrome: Potential mechanisms
    Chao Tang, Yuxin Wang, Zeyu Xu, Dan Chen, Jingguo Xu, Duo Yang, Li Zhang, Jun Liu, Juan Kan
    Food Bioscience.2024; 59: 104261.     CrossRef
  • Obesity, Dietary Patterns, and Hormonal Balance Modulation: Gender-Specific Impacts
    Elisa Mazza, Ersilia Troiano, Yvelise Ferro, Fabrizia Lisso, Martina Tosi, Ettore Turco, Roberta Pujia, Tiziana Montalcini
    Nutrients.2024; 16(11): 1629.     CrossRef
  • Mitochondrial quality control in human health and disease
    Bo-Hao Liu, Chen-Zhen Xu, Yi Liu, Zi-Long Lu, Ting-Lv Fu, Guo-Rui Li, Yu Deng, Guo-Qing Luo, Song Ding, Ning Li, Qing Geng
    Military Medical Research.2024;[Epub]     CrossRef
  • Adalimumab Treatment Effects on Inflammation and Adipose Tissue Mitochondrial Respiration in Hidradenitis Suppurativa
    Ronni Eg Sahl, Axel Illeris Poggi, Valdemar Wendelboe Nielsen, Yiqiu Yao, Ioanna Patsi, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Simon Francis Thomsen, Jørn Wulff Helge
    Endocrinology, Diabetes & Metabolism.2024;[Epub]     CrossRef
  • Dietary vegetable Sarcochlamys pulcherrima Gaud. and its bioactive compound myricitrin promotes white adipose browning in obese models via AMPK/SIRT1/UCP1 upregulation.
    Shalini Gurumayum, Devi Basumatary, Pranamika Sarma, Kangkon Saikia, Deepsikha Swargiary, Semim Ahmed Akhtar, Abhipsha Saikia, Jagat Chandra Borah
    Food Bioscience.2024; : 105292.     CrossRef
  • Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence
    Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
    Critical Reviews in Food Science and Nutrition.2023; 63(26): 8320.     CrossRef
  • The emergent role of mitochondrial RNA modifications in metabolic alterations
    Hatim Boughanem, Yvonne Böttcher, João Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, Akin Cayir, Manuel Macias‐González
    WIREs RNA.2023;[Epub]     CrossRef
  • Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
    Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
    Aging Cell.2023;[Epub]     CrossRef
  • Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023
    Harold Edward Bays, Shagun Bindlish, Tiffany Lowe Clayton
    Obesity Pillars.2023; 5: 100056.     CrossRef
  • A role of STING signaling in obesity-induced lung inflammation
    Yong Qi, Zhuhua Wu, Dan Chen, Li Zhu, Yunlei Yang
    International Journal of Obesity.2023; 47(4): 325.     CrossRef
  • Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
    Alina Kuryłowicz
    Biomedicines.2023; 11(3): 690.     CrossRef
  • White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
    Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz
    Nutrients.2023; 15(7): 1722.     CrossRef
  • Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process
    Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Muñoz, Rita de Cássia Marqueti, José Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
    Ageing Research Reviews.2023; 87: 101935.     CrossRef
  • The impact of metabolic endotoxaemia on the browning process in human adipocytes
    Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian
    BMC Medicine.2023;[Epub]     CrossRef
  • Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH
    Yoshinori Marunaka
    Biomolecules.2023; 13(5): 779.     CrossRef
  • From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs
    Gina Cavaliere, Fabiano Cimmino, Giovanna Trinchese, Angela Catapano, Lidia Petrella, Margherita D’Angelo, Lucio Lucchin, Maria Pina Mollica
    Antioxidants.2023; 12(6): 1172.     CrossRef
  • Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism
    Klaudia Gutowska, Krzysztof Czajkowski, Alina Kuryłowicz
    International Journal of Molecular Sciences.2023; 24(13): 10982.     CrossRef
  • Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction
    Dandan Jia, Zhenjun Tian, Ru Wang
    Ageing Research Reviews.2023; 91: 102087.     CrossRef
  • Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
    Ines Martic, Federica Papaccio, Barbara Bellei, Maria Cavinato
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review
    Dominika Mazur, Małgorzata Satora, Anna K. Rekowska, Zuzanna Kabała, Aleksandra Łomża, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak
    Current Issues in Molecular Biology.2023; 45(11): 9003.     CrossRef
  • AGER-1 Long Non-Coding RNA Levels Correlate with the Expression of the Advanced Glycosylation End-Product Receptor, a Regulator of the Inflammatory Response in Visceral Adipose Tissue of Women with Obesity and Type 2 Diabetes Mellitus
    Klaudia Gutowska, Krzysztof Koźniewski, Michał Wąsowski, Marta Izabela Jonas, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka, Krzysztof Czajkowski, Ali
    International Journal of Molecular Sciences.2023; 24(24): 17447.     CrossRef
  • Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
    Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
    Cardiovascular Research.2022; 118(2): 489.     CrossRef
  • Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer
    Simon Lecoutre, Karine Clément, Isabelle Dugail
    International Journal of Molecular Sciences.2022; 23(2): 632.     CrossRef
  • IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity
    Tuan Anh Phu, Martin Ng, Ngan K. Vu, Laura Bouchareychas, Robert L. Raffai
    Molecular Therapy.2022; 30(6): 2274.     CrossRef
  • Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
    Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen, Vesa M. Olkkonen
    Molecular Medicine.2022;[Epub]     CrossRef
  • Modulation of adipose inflammation by cellular retinoic acid-binding protein 1
    Chin-Wen Wei, Jennifer Nhieu, Yu-Lung Lin, Li-Na Wei
    International Journal of Obesity.2022; 46(10): 1759.     CrossRef
  • The Role of Adipokines in Pancreatic Cancer
    Qi Wang, Huizhi Wang, Yuntao Ding, Mengtian Wan, Min Xu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
    Federica Zatterale, Gregory Alexander Raciti, Immacolata Prevenzano, Alessia Leone, Michele Campitelli, Veronica De Rosa, Francesco Beguinot, Luca Parrillo
    Biomolecules.2022; 12(7): 982.     CrossRef
  • Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy
    Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci
    International Journal of Molecular Sciences.2022; 23(15): 8659.     CrossRef
  • Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease
    Ioan-Andrei Iliuta, Xuewen Song, Lauren Pickel, Amirreza Haghighi, Ravi Retnakaran, James Scholey, Hoon-Ki Sung, Gregory R. Steinberg, York Pei
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
    Ruwen Wang, Qin Sun, Xianmin Wu, Yiyin Zhang, Xiaorui Xing, Kaiqing Lin, Yue Feng, Mingqi Wang, Yibing Wang, Ru Wang
    Cells.2022; 11(23): 3735.     CrossRef
  • Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
    Liwen Wang, Jie Hu, Haiyan Zhou
    The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
  • ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
    Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo
    Autophagy.2021; 17(10): 2856.     CrossRef
  • GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH
    Kook Hwan Kim, Myung-Shik Lee
    Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(3): 129834.     CrossRef
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    Alison J. Eastman, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy, David M. Aronoff
    Clinical Therapeutics.2021; 43(2): 265.     CrossRef
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    Geetanjali Sharma, Eric R. Prossnitz
    Endocrine and Metabolic Science.2021; 2: 100080.     CrossRef
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    Journal of Clinical Medicine.2021; 10(4): 745.     CrossRef
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    Ye-shi Chen, Xin-ping Ouyang, Xiao-hua Yu, Petr Novák, Le Zhou, Ping-ping He, Kai Yin
    Journal of Cardiovascular Translational Research.2021; 14(5): 857.     CrossRef
  • From Metabolic Syndrome to Neurological Diseases: Role of Autophagy
    Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
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    Sofie Lionett, Ida Almenning Kiel, Ragnhild Røsbjørgen, Stian Lydersen, Steen Larsen, Trine Moholdt
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
    Yoshinori Marunaka
    Biochemical Society Transactions.2021; 49(2): 715.     CrossRef
  • The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview
    Dimitrios Tsilingiris, Evangelia Tzeravini, Chrysi Koliaki, Maria Dalamaga, Alexander Kokkinos
    Current Obesity Reports.2021; 10(3): 191.     CrossRef
  • Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity
    Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto, Eduardo Tibirica
    Journal of Inflammation Research.2021; Volume 14: 2267.     CrossRef
  • Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
    Bruna B. Brandão, Ankita Poojari, Atefeh Rabiee
    International Journal of Molecular Sciences.2021; 22(11): 5906.     CrossRef
  • Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis
    Sylwia Dziegielewska-Gesiak
    Clinical Interventions in Aging.2021; Volume 16: 1057.     CrossRef
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    Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Na
    Redox Biology.2021; 46: 102087.     CrossRef
  • New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes
    Hannah Maude, Winston Lau, Nikolas Maniatis, Toby Andrew
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats
    Ying Xue, Ran Li, Yong Zhao, Ling Li, Yun Zhou
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
    Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
    Scientific Reports.2021;[Epub]     CrossRef
  • Reliability and variation in mitochondrial respiration in human adipose tissue
    Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen
    Adipocyte.2021; 10(1): 605.     CrossRef
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    Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz
    Cell Communication and Signaling.2021;[Epub]     CrossRef
  • microRNAs in Human Adipose Tissue Physiology and Dysfunction
    Alina Kurylowicz
    Cells.2021; 10(12): 3342.     CrossRef
  • Aging, obese-insulin resistance, and bone remodeling
    Napatsorn Imerb, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
    Mechanisms of Ageing and Development.2020; 191: 111335.     CrossRef
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    Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele, Francesco Beguinot
    Frontiers in Physiology.2020;[Epub]     CrossRef
  • Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
    Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R Krycer, Pablo E Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A Rothermel, Sergio Lavandero
    Endocrine Reviews.2020;[Epub]     CrossRef
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    Farah Omran, Mark Christian
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
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    Marta Fernández-Galilea, Elisa Félix-Soriano, Ignacio Colón-Mesa, Xavier Escoté, Maria J. Moreno-Aliaga
    Journal of Physiology and Biochemistry.2020; 76(2): 251.     CrossRef
  • Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
    Alina Kuryłowicz, Krzysztof Koźniewski
    Molecules.2020; 25(9): 2224.     CrossRef
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    Mariana Renovato-Martins, Catharina Moreira-Nunes, Georgia C. Atella, Christina Barja-Fidalgo, João Alfredo de Moraes
    Nutrients.2020; 12(9): 2828.     CrossRef
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    Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
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    Fei Wang, Shuchun Chen, Luping Ren, Yichao Wang, Zelin Li, Tiantian Song, He Zhang, Qiwen Yang
    Frontiers in Pharmacology.2020;[Epub]     CrossRef
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    Journal of Clinical Medicine.2020; 9(1): 213.     CrossRef
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    Food Science and Biotechnology.2020; 29(11): 1511.     CrossRef
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    Endocrine and Metabolic Science.2020; 1(3-4): 100061.     CrossRef
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  • Adipogenesis: A Necessary but Harmful Strategy
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    International Journal of Molecular Sciences.2019; 20(15): 3657.     CrossRef
Original Article
Inducible Nitric Oxide Synthase (iNOS) Expression in the Hypoxic Injury to Pancreatic Beta (MIN6) Cells.
Seung Hyun Ko, Seung Bum Kim, Kyung Ryul Ryu, Ji Won Kim, Yu Bai Ahn, Sung Dae Moon, Sung Rae Kim, Jung Min Lee, Hyuk Snag Kwon, Kun Ho Yoon, Ki Ho Song
Korean Diabetes J. 2006;30(5):336-346.   Published online September 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.5.336
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AbstractAbstract PDF
BACKGROUND
Islet transplantation is an alternative potential strategy to cure type 1 diabetes mellitus. However, two or more donors are usually needed for one recipient because a substantial part of the graft becomes nonfunctional due to several factors including hypoxia. Though hypoxic exposure of pancreatic beta cells has been reported to induce apoptotic cell death, the molecular processes involved in hypoxia-induced cell death are poorly understood. In type I diabetes, Nitric Oxide (NO) is known as an important cytokine, involved in the pathogenesis of beta cell dysfunction. Pancreatic beta cells are sensitive to the induction of inducible nitric oxide synthase (iNOS) when stimulated by TNF-a or IL-1beta. But contribution of iNOS in response to hypoxia is not yet fully understood. METHODS: Mouse insulinoma cells (MIN6) were incubated in an anaerobic chamber (75% N2/15% CO2/5% H2) for up to 12 hours. Cell viability was measured after AO/PI staining. Caspase-3 activation was also determined using Western blot analysis. Nitric Oxide (NO) release into culture medium was measured using a Griess reagent. The expression of iNOS and PDX-1 mRNA and iNOS protein was examined using real time PCR and Western blot analysis. RESULTS: Marked cell death was observed within 6 hours after hypoxic exposure of MIN6 cells (control, < 5%; 2 hr, 11.0+/-7.6%; 6 hr, 46.2+/-12.8%, P < 0.05). Immunoreactivity to activated caspase-3 was observed at 2, 4 and 6 hrs. NO production was increased in a time dependent manner. Expression of iNOS mRNA and protein was significantly increased at 4 and 6 hour after hypoxia. iNOS expression was confirmed by immunostaining. Of note, Pdx-1 mRNA expression was markedly attenuated by hypoxic treatment. Pretreatment with a selective iNOS inhibitor, 1400 W, significantly prevented beta cell death induced by hypoxic injury. CONCLUSION: Our data suggest that iNOS-NO play an important role in hypoxic injury to MIN6 cells. Therefore, iNOS-NO might be a potential therapeutic target for improving engraftment of the transplanted islets and suppression of iNOS would be helpful for prevention of beta cells damage to hypoxic injury.

Diabetes Metab J : Diabetes & Metabolism Journal
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