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1 "Hyperandrogenism"
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Original Article
FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women
Do Kyeong Song, Hyejin Lee, Jee-Young Oh, Young Sun Hong, Yeon-Ah Sung
Diabetes Metab J. 2014;38(4):302-310.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.302
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  • 25 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   
Background

The fat mass and obesity-associated (FTO) gene is associated with obesity and type 2 diabetes mellitus. Obesity and insulin resistance are also common features of polycystic ovary syndrome (PCOS). Therefore, the FTO gene might be a candidate gene for PCOS susceptibility. The aim of the present study was to evaluate the effects of FTO gene variants on PCOS susceptibility and metabolic and reproductive hormonal parameters.

Methods

We recruited 432 women with PCOS (24±5 years) and 927 healthy women with regular menstrual cycles (27±5 years) and performed a case-control association study. We genotyped the single nucleotide polymorphisms rs1421085, rs17817449, and rs8050136 in the FTO gene and collected metabolic and hormonal measurements.

Results

Logistic regression revealed that the G/G genotype (rs1421085, 1.6%), the C/C genotype (rs17817449, 1.6%), and the A/A genotype (rs8050136, 1.6%) were strongly associated with an increased risk of PCOS (odds ratio, 2.551 to 2.559; all P<0.05). The strengths of these associations were attenuated after adjusting for age and BMI. The women with these genotypes were more obese and exhibited higher free androgen indices (P<0.05) and higher free testosterone levels (P=0.053 to 0.063) compared to the other genotypes. However the significant differences disappeared after adjusting for body mass index (BMI). When we analyzed the women with PCOS and the control groups separately, there were no significant differences in the metabolic and reproductive hormonal parameters according to the FTO gene variants.

Conclusion

The rs1421085, rs17817449, and rs8050136 variants of the FTO gene were associated with PCOS susceptibility and hyperandrogenemia in young Korean women. These associations may be mediated through an effect of BMI.

Citations

Citations to this article as recorded by  
  • Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
    Prakash Patil, Neevan D'Souza, Sudeep D. Ghate, Lakshmi Nagendra, Harish B. Girijashankar
    Journal of Health and Allied Sciences NU.2023; 13(03): 380.     CrossRef
  • Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS
    Wassim Y. Almawi, Rita Nemr, Tomiris Atazhanova, Zainab H. Malalla, Sameh Sarray, Fekria E. Mustafa, Naeema A. Mahmood
    Reproductive Sciences.2023; 30(7): 2166.     CrossRef
  • FTO: a critical role in obesity and obesity-related diseases
    Dan Yin, Yiyang Li, Xingyue Liao, Dewei Tian, Yunsi Xu, Cuilan Zhou, Jun Liu, Suyun Li, Jing Zhou, Yulin Nie, Hongqing Liao, Cuiying Peng
    British Journal of Nutrition.2023; 130(10): 1657.     CrossRef
  • Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India
    Hiral Chaudhary, Jalpa Patel, Nayan K. Jain, Sonal Panchal, Naresh Laddha, Rushikesh Joshi
    BMC Medical Genomics.2023;[Epub]     CrossRef
  • ASSOCIATION BETWEEN FAT MASS AND OBESITY ASSOCIATED (FTO) RS17817449 GENE POLYMORPHISM WITH INSULIN RESISTANCE AND OBESITY IN THE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
    Mahbobeh Moayeri, Masoumeh Nezhadali, Mahnaz Mohamadi
    Studies in Medical Sciences.2023; 33(12): 868.     CrossRef
  • Association of FTO gene variants rs9939609 and rs1421085 with polycystic ovary syndrome
    Alaa A. Alnafjan, Afrah F. Alkhuriji, Hussah M. Alobaid, Zainb A. Babay, Mahmoud I. Khalil
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
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    Zeinab Naghshband, Suttur S. Malini
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome
    Giorgia Scarfò, Simona Daniele, Jonathan Fusi, Marco Gesi, Claudia Martini, Ferdinando Franzoni, Vito Cela, Paolo Giovanni Artini
    Biomedicines.2022; 10(6): 1305.     CrossRef
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    Sadaf Parveen, Saba Khan, Haseeb Ahsan, Priyanka Thapa Manger, Bhavana Gupta, Roshan Alam
    Human Nutrition & Metabolism.2022; 30: 200174.     CrossRef
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    Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi, Mehdi Moradinazar
    Genes & Nutrition.2022;[Epub]     CrossRef
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    Umayal Branavan, Sulochana Wijesundera, Vishvanath Chandrasekaran, Carukshi Arambepola, Chandrika Wijeyaratne
    BMC Medical Genetics.2020;[Epub]     CrossRef
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    Ayçıl ÖZTURAN ŞİRİN, Yasemin AKDEVELİOĞLU
    Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi.2020; 4(3): 275.     CrossRef
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    Do Kyeong Song, Hyejin Lee, Young Sun Hong, Yeon-Ah Sung
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
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    Jin Ju Kim, Young Min Choi
    Journal of Obstetrics and Gynaecology Research.2019; 45(12): 2330.     CrossRef
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    Ritu Deswal, Arun Yadav, Amita Suneja Dang
    Systems Biology in Reproductive Medicine.2018; 64(1): 12.     CrossRef
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    Farzaneh Ghafarian-Alipour, Shayan Ziaee, Mohamad Reza Ashoori, Mir Saeid Zakeri, Mohammad Ali Boroumand, Naser Aghamohammadzadeh, Maryam Abbasi-Majdi, Fatemeh Shool, Navid Sarakhs Asbaghi, Abolghasem Mohammadi, Nosratollah Zarghami
    Gene.2018; 641: 361.     CrossRef
  • The role of FTO variants in the susceptibility of polycystic ovary syndrome and in vitro fertilization outcomes in Chinese women
    Ai Ling Liu, Hong Qing Liao, Jing Zhou, Yu Lin Nie, Cui Lan Zhou, Zhi Liang Li, Zi Fen Guo, Dong Xiu He, Yun Hua Zhu, Cui Ying Peng
    Gynecological Endocrinology.2018; 34(8): 719.     CrossRef
  • Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
    Joel Eriksson, Robin Haring, Niels Grarup, Liesbeth Vandenput, Henri Wallaschofski, Erik Lorentzen, Torben Hansen, Dan Mellström, Oluf Pedersen, Matthias Nauck, Mattias Lorentzon, Lise Lotte Nystrup Husemoen, Henry Völzke, Magnus Karlsson, Sebastian E. Ba
    PLOS ONE.2017; 12(4): e0176277.     CrossRef
  • Post-transcriptional gene regulation by mRNA modifications
    Boxuan Simen Zhao, Ian A. Roundtree, Chuan He
    Nature Reviews Molecular Cell Biology.2017; 18(1): 31.     CrossRef
  • The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
    Do Kyeong Song, Yeon-Ah Sung, Hyejin Lee, Wan-Xi Yang
    PLOS ONE.2016; 11(9): e0163756.     CrossRef
  • Haplotyping strategy highlights the specificity of FTO gene association with polycystic ovary syndrome in Tunisian women population
    Assila Ben Salem, Redha Attaoua, Nabil Mtiraoui, Sawssen Meddeb, Olfa Kacem, Mounir Ajina, Moncef Souissi, Patrick Poucheret, Christophe Normand, Touhami Mahjoub, Florin Grigorescu
    Gene.2015; 565(2): 166.     CrossRef
  • FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil
    Ramon B. Ramos, Poli Mara Spritzer
    Gene.2015; 560(1): 25.     CrossRef
  • Interaction between common variants of FTO and MC4R is associated with risk of PCOS
    Huiqin Yuan, Guoping Zhu, Fang Wang, Xiang Wang, Huihui Guo, Mo Shen
    Reproductive Biology and Endocrinology.2015;[Epub]     CrossRef

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