Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal



Page Path
HOME > Search
2 "Glycation end products, advanced"
Article category
Publication year
Funded articles
Article image
Treatment of Diabetic Kidney Disease: Current and Future
Tomotaka Yamazaki, Imari Mimura, Tetsuhiro Tanaka, Masaomi Nangaku
Diabetes Metab J. 2021;45(1):11-26.   Published online January 22, 2021
  • 20,424 View
  • 1,371 Download
  • 95 Web of Science
  • 94 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Diabetic kidney disease (DKD) is the major cause of end-stage kidney disease. However, only renin-angiotensin system inhibitor with multidisciplinary treatments is effective for DKD. In 2019, sodium-glucose cotransporter 2 (SGLT2) inhibitor showed efficacy against DKD in Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, adding a new treatment option. However, the progression of DKD has not been completely controlled. The patients with transient exposure to hyperglycemia develop diabetic complications, including DKD, even after normalization of their blood glucose. Temporary hyperglycemia causes advanced glycation end product (AGE) accumulations and epigenetic changes as metabolic memory. The drugs that improve metabolic memory are awaited, and AGE inhibitors and histone modification inhibitors are the focus of clinical and basic research. In addition, incretin-related drugs showed a renoprotective ability in many clinical trials, and these trials with renal outcome as their primary endpoint are currently ongoing. Hypoxia-inducible factor prolyl hydroxylase inhibitors recently approved for renal anemia may be renoprotective since they improve tubulointerstitial hypoxia. Furthermore, NF-E2–related factor 2 activators improved the glomerular filtration rate of DKD patients in Bardoxolone Methyl Treatment: Renal Function in chronic kidney disease/Type 2 Diabetes (BEAM) trial and Phase II Study of Bardoxolone Methyl in Patients with Chronic Kidney Disease and Type 2 Diabetes (TSUBAKI) trial. Thus, following SGLT2 inhibitor, numerous novel drugs could be utilized in treating DKD. Future studies are expected to provide new insights.


Citations to this article as recorded by  
  • Clinical value of serum MMP-3 in chronic kidney disease
    Yulin Fu, Cheng Song, Yuan Qin, Tianyu Zheng, Xiumei Zhou, Xueqin Zhao, Jian Zou, Biao Huang
    Clinica Chimica Acta.2024; 553: 117725.     CrossRef
  • β2-Adrenergic receptor agonists as a treatment for diabetic kidney disease
    Ehtesham Arif, Danira Medunjanin, Ashish Solanki, Xiaofeng Zuo, Yanhui Su, Yujing Dang, Brennan Winkler, Kasey Lerner, Ahmed I. Kamal, Oleg Palygin, Marc-Andre Cornier, Bethany J. Wolf, Kelly J. Hunt, Joshua H. Lipschutz
    American Journal of Physiology-Renal Physiology.2024; 326(1): F20.     CrossRef
  • β2-Adrenergic receptor agonists: a new treatment for diabetic kidney disease?
    Zhiwen Liu, Zheng Dong
    American Journal of Physiology-Renal Physiology.2024; 326(1): F1.     CrossRef
  • Urinary exosomal microRNA-145-5p and microRNA-27a-3p act as noninvasive diagnostic biomarkers for diabetic kidney disease
    Lu-Lu Han, Sheng-Hai Wang, Ming-Yan Yao, Hong Zhou
    World Journal of Diabetes.2024; 15(1): 92.     CrossRef
  • Placenta-derived mesenchymal stem cells protect against diabetic kidney disease by upregulating autophagy-mediated SIRT1/FOXO1 pathway
    Honghong Liu, Jiao Wang, Guanru Yue, Jixiong Xu
    Renal Failure.2024;[Epub]     CrossRef
  • Association of serum Nrf2 protein levels with disease activity and renal impairment in lupus nephritis
    Jicui Li, Qiaoyan Guo, Xianping Wei, Yuexin Zhu, Manyu Luo, Ping Luo
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Effects of Qidan Tangshen Granule on diabetic kidney disease in patients with type 2 diabetes
    Hua Yang, Shisi Xia, Yilei Cong, Xinyu Yang, Jie Min, Tengfei Wu
    Diabetes Research and Clinical Practice.2024; 209: 111128.     CrossRef
  • Comparison of conventional mathematical model and machine learning model based on recent advances in mathematical models for predicting diabetic kidney disease
    Yingda Sheng, Caimei Zhang, Jing Huang, Dan Wang, Qian Xiao, Haocheng Zhang, Xiaoqin Ha
    DIGITAL HEALTH.2024;[Epub]     CrossRef
  • Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy
    Yinfeng Chen, Xiaying Wang, Jie Min, Jie Zheng, Xuanli Tang, Xiaoling Zhu, Dongrong Yu, De Jin
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 739.     CrossRef
  • Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway
    Xinwang Zhu, Congxiao Zhang, Linlin Liu, Li Xu, Li Yao
    International Journal of Molecular Medicine.2024;[Epub]     CrossRef
  • Decreased risk of renal cell carcinoma in patients with type 2 diabetes treated with sodium glucose cotransporter‐2 inhibitors
    Chun‐Huei Chiu, Wei‐Yao Wang, Hung‐Yi Chen, Pei‐Lun Liao, Gwo‐Ping Jong, Tsung‐Yuan Yang
    Cancer Science.2024; 115(6): 2059.     CrossRef
  • System biology approaches for systemic diseases: Emphasis on type II diabetes mellitus and allied metabolism
    Mohan Das, Moumita Chakraborty, Promi Das, Sayantan Santra, Abhishek Mukherjee, Sarobi Das, Krisztian Banyai, Souvik Roy, Lopamudra Choudhury, Rudrak Gupta, Tama Dey, Dibya Das, Anirbandeep Bose, Balasubramanian Ganesh, Rintu Banerjee
    Biocatalysis and Agricultural Biotechnology.2024; 58: 103176.     CrossRef
  • Two-Dimensional Ultrasound-Based Radiomics Nomogram for Diabetic Kidney Disease: A Pilot Study
    Xingyue Huang, Yugang Hu, Yao Zhang, Qing Zhou
    International Journal of General Medicine.2024; Volume 17: 1877.     CrossRef
  • Autocatalytic, Brain Tumor‐Targeting Delivery of Bardoxolone Methyl Self‐Assembled Nanoparticles for Glioblastoma Treatment
    Zhang Ye, Wendy C. Sheu, Huan Qu, Bin Peng, Jia Liu, Li Zhang, Fanen Yuan, Yuxin Wei, Jiangbing Zhou, Qianxue Chen, Xuan Xiao, Shenqi Zhang
    Small Science.2024;[Epub]     CrossRef
  • Beneficial effects of ginsenosides on diabetic nephropathy: A systematical review and meta-analysis of preclinical evidence
    Xiao-Mei Chen, Gui-Xuan Lin, Xue Wang, Hong-Yan Ma, Ru-Shang Wang, Shu-Mei Wang, Dan Tang
    Journal of Ethnopharmacology.2023; 302: 115860.     CrossRef
  • Waist circumference and end‐stage renal disease based on glycaemic status: National Health Insurance Service data 2009–2018
    Yun Kyung Cho, Ji Hye Huh, Shinje Moon, Yoon Jung Kim, Yang‐Hyun Kim, Kyung‐do Han, Jun Goo Kang, Seong Jin Lee, Sung‐Hee Ihm
    Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 585.     CrossRef
  • A Narrative Review of New Treatment Options for Diabetic Nephropathy
    Aadhira Pillai, Darshna Fulmali
    Cureus.2023;[Epub]     CrossRef
  • Shenkang recipe alleviates renal aging in diabetic kidney disease by interfering with the lysine-specific demethylase KDM6B to modulate the PPAR-γ signaling pathway
    Anna Zuo, Jiarun Xie, Junqiao Shao, Shuyu Li, Haoyu Lin, Shaoting Wang, Wei Sun, Jinjin Xia, Weiqiang Jiang, Jia Sun, Ming Wang
    Pharmacological Research - Modern Chinese Medicine.2023; 6: 100216.     CrossRef
  • miR-223-3p mediates the diabetic kidney disease progression by targeting IL6ST/STAT3 pathway
    Ping Tang, Yushan Xu, Jingrong Zhang, Juanli Nan, Ruxian Zhong, Jingmei Luo, Dazhi Xu, Shaoqing Shi, Lihua Zhang
    Biochemical and Biophysical Research Communications.2023; 648: 50.     CrossRef
  • miR‐124‐3p improves mitochondrial function of renal tubular epithelial cells in db/db mice
    Luqun Liang, Chunxin Wo, Yao Yuan, Hongjuan Cao, Wanlin Tan, Xingcheng Zhou, Dan Wang, Rongyu Chen, Mingjun Shi, Fan Zhang, Ying Xiao, Lingling Liu, Yuxia Zhou, Tian Zhang, Yuanyuan Wang, Bing Guo
    The FASEB Journal.2023;[Epub]     CrossRef
  • Hypoxia-Inducible Factor-Prolyl-Hydroxylase and Sodium-Glucose Cotransporter 2 Inhibitors for Low-Risk Myelodysplastic Syndrome-Related Anemia in Patients with Chronic Kidney Disease: A Report of Three Cases
    Satoshi Yamasaki, Takahiko Horiuchi
    Hematology Reports.2023; 15(1): 180.     CrossRef
  • Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus
    Amul Badr, Omayma Elkholy, Mona Said, Sally Fahim, Mohamed El-Khatib, Dina Sabry, Radwa Gaber
    Journal of Medical Biochemistry.2023; 42(2): 239.     CrossRef
  • The emerging insight into E3 ligases as the potential therapeutic target for diabetic kidney disease
    Vivek Akhouri, Syamantak Majumder, Anil Bhanudas Gaikwad
    Life Sciences.2023; 321: 121643.     CrossRef
  • Klotho’s impact on diabetic nephropathy and its emerging connection to diabetic retinopathy
    Anqi Tang, Yu Zhang, Ling Wu, Yong Lin, Lizeyu Lv, Liangbin Zhao, Bojun Xu, Youqun Huang, Mingquan Li
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries
    Hui Liu, Dongyan Wang, Jingnan Tang, Linlin Yu, Shanshan Su
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1085.     CrossRef
  • Medial Arterial Calcification and the Risk of Amputation of Diabetic Foot Ulcer in Patients With Diabetic Kidney Disease
    Joon Myeong So, Ji Ho Park, Jin Gyeong Kim, Il Rae Park, Eun Yeong Ha, Seung Min Chung, Jun Sung Moon, Chul Hyun Park, Woo-Sung Yun, Tae-Gon Kim, Woong Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy
    Baranca Buijsers, Marjolein Garsen, Mark de Graaf, Marinka Bakker-van Bebber, Chunming Guo, Xue Li, Johan van der Vlag
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • Influence of non-alcoholic steatohepatitis on the renal functional status in patients with type 2 diabetes and diabetic kidney disease
    Z.Ya. Кotsiubiichuk, O.S. Khukhlina, А.А. Аntoniv, O.Ye. Mandryk
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(2): 100.     CrossRef
  • Roles of extracellular vesicles in ageing-related chronic kidney disease: Demon or angel
    Siqi Yin, Zixuan Zhou, Peiwen Fu, Chaoying Jin, Peipei Wu, Cheng Ji, Yunjie Shan, Linru Shi, Min Xu, Hui Qian
    Pharmacological Research.2023; 193: 106795.     CrossRef
  • Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer
    Giovanni Tossetta, Sonia Fantone, Daniela Marzioni, Roberta Mazzucchelli
    Cancers.2023; 15(11): 3037.     CrossRef
  • Risk factors for heart, cerebrovascular, and kidney diseases: evaluation of potential side effects of medications to control hypertension, hyperglycemia, and hypercholesterolemia
    Kazumitsu Nawata
    Frontiers in Cardiovascular Medicine.2023;[Epub]     CrossRef
  • Rationale and design of a prospective, clinical study of kidney biopsies in people with type 2 diabetes and severely increased albuminuria (the PRIMETIME 2 study)
    Marie Møller, Rikke Borg, Iain Bressendorff, Lisbeth N Fink, Eva Gravesen, Karina Haar Jensen, Torben Hansen, Dorrit Krustrup, Frederik Persson, Peter Rossing, Frederikke E Sembach, Anne C B Thuesen, Ditte Hansen
    BMJ Open.2023; 13(6): e072216.     CrossRef
  • Oral Chinese patent medicines for diabetic kidney disease: An overview of systematic reviews
    Xue Xue, Ke-ying Li, Shang-zhi Liu, Jia-xuan Li, Xin-yan Jin, Xue-han Liu, La-mei Lin, Xin-rong Zou, Chun-li Lu, Fang-fang Zhao, Jian-ping Liu, Xiao-qin Wang
    European Journal of Integrative Medicine.2023; 61: 102269.     CrossRef
  • Recent Advances in Proteinuric Kidney Disease/Nephrotic Syndrome: Lessons from Knockout/Transgenic Mouse Models
    Ryosuke Saiki, Kan Katayama, Kaoru Dohi
    Biomedicines.2023; 11(7): 1803.     CrossRef
  • Epigenetic regulation of angiogenesis and ischemic response by long noncoding RNA LEENE in diabetes
    Imari Mimura, Masaomi Nangaku
    Kidney International.2023; 104(6): 1048.     CrossRef
  • Advances in the pharmacological study of Chinese herbal medicine to alleviate diabetic nephropathy by improving mitochondrial oxidative stress
    Ming Chen, Yao Chen, Wenhui Zhu, Xiaoming Yan, Jing Xiao, Peiqing Zhang, Peng Liu, Ping Li
    Biomedicine & Pharmacotherapy.2023; 165: 115088.     CrossRef
  • A Systematic Review and Meta-Analysis on the Efficacy and Safety of Finerenone Therapy in Patients with Cardiovascular and Chronic Kidney Diseases in Type 2 Diabetes Mellitus
    FNU Jyotsna, Kamran Mahfooz, Tirath Patel, FNU Parshant, Fnu Simran, Fnu Harsha, Fnu Neha, Dev Jyotishna, Dipesh Mishra, Sirjana Subedi, Mahima Khatri, Satesh Kumar, Giustino Varrassi
    Cureus.2023;[Epub]     CrossRef
  • Molecular implications of glycosaminoglycans in diabetes pharmacotherapy
    Tanya Waseem, Madiha Ahmed, Tausif Ahmed Rajput, Mustafeez Mujtaba Babar
    International Journal of Biological Macromolecules.2023; 247: 125821.     CrossRef
  • SGLT2 Inhibitors in the Treatment of Diabetic Kidney Disease: More than Just Glucose Regulation
    Jasna Klen, Vita Dolžan
    Pharmaceutics.2023; 15(7): 1995.     CrossRef
  • CUL3 induces mitochondrial dysfunction via MRPL12 ubiquitination in renal tubular epithelial cells
    Xingzhao Ji, Xiaoli Yang, Xia Gu, Lingju Chu, Shengnan Sun, Jian Sun, Peng Song, Qian Mu, Ying Wang, Xiaoming Sun, Dun Su, Tong Su, Shaoshuai Hou, Yao Lu, Chen Ma, Mingqiang Liu, Tianyi Zhang, Weiying Zhang, Yi Liu, Qiang Wan
    The FEBS Journal.2023; 290(22): 5340.     CrossRef
  • HP1 induces ferroptosis of renal tubular epithelial cells through NRF2 pathway in diabetic nephropathy
    Chuanqiang Zhou, Min Wu, Gaolun Liu, Li Zhou
    Open Life Sciences.2023;[Epub]     CrossRef
  • A Review of the Potential of Nuclear Factor [Erythroid-Derived 2]-like 2 Activation in Autoimmune Diseases
    Ilker Ates, Ayşe Didem Yılmaz, Brigitta Buttari, Marzia Arese, Luciano Saso, Sibel Suzen
    Brain Sciences.2023; 13(11): 1532.     CrossRef
  • Astragalus membranaceus and Salvia miltiorrhiza ameliorate diabetic kidney disease via the “gut-kidney axis”
    Zhen Shen, Tao Cui, Yao Liu, Shuai Wu, Cong Han, Jie Li
    Phytomedicine.2023; 121: 155129.     CrossRef
  • The relevance of the non-invasive biomarkers lncRNA GAS5/miR-21 ceRNA regulatory network in the early identification of diabetes and diabetic nephropathy
    He Sun, Tong Chen, Xin Li, Yonghong Zhu, Shuang Zhang, Ping He, Yali Peng, Qiuling Fan
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy
    Jian Lu, Xue Qi Li, Pei Pei Chen, Jia Xiu Zhang, Liang Liu, Gui Hua Wang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Kun Ling Ma
    JCI Insight.2023;[Epub]     CrossRef
  • SET7, a lysine-specific methyl transferase: An intriguing epigenetic target to combat diabetic nephropathy
    Samarth Dwivedi, Atharva Chavan, Atish T. Paul
    Drug Discovery Today.2023; 28(10): 103754.     CrossRef
  • Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia
    Tomotaka Yamazaki, Imari Mimura, Yu Kurata, Tetsuhiro Tanaka, Masaomi Nangaku
    Physiological Reports.2023;[Epub]     CrossRef
  • GLP-1RAs inhibit the activation of the NLRP3 inflammasome signaling pathway to regulate mouse renal podocyte pyroptosis
    Xiang Li, Xiao Jiang, Mei Jiang, Zhi-feng Wang, Tao Zhao, Si-ming Cao, Qiu-Mei Li
    Acta Diabetologica.2023; 61(2): 225.     CrossRef
  • Highly Sensitive, Portable Detection System for Multiplex Chemiluminescence Analysis
    Yannan Yu, Wei Nie, Kaiqin Chu, Xi Wei, Zachary J. Smith
    Analytical Chemistry.2023; 95(39): 14762.     CrossRef
  • From normal population to prediabetes and diabetes: study of influencing factors and prediction models
    Di Gong, Xiaohong Chen, Lin Yang, Yongjian Zhang, Qianqian Zhong, Jing Liu, Chen Yan, Yongjiang Cai, Weihua Yang, Jiantao Wang
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Diabetes Monitoring through Urine Analysis Using ATR-FTIR Spectroscopy and Machine Learning
    Sajid Farooq, Denise Maria Zezell
    Chemosensors.2023; 11(11): 565.     CrossRef
  • Treatment and practical considerations of diabetic kidney disease
    Yara Bilen, Allaa Almoushref, Kenda Alkwatli, Omar Osman, Ali Mehdi, Hanny Sawaf
    Frontiers in Medicine.2023;[Epub]     CrossRef
  • Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment
    Jing Li, Na Zhu, Yaqiong Wang, Yanlei Bao, Feng Xu, Fengjuan Liu, Xuefeng Zhou
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 4269.     CrossRef
  • Cardiovascular autonomic neuropathy and incident diabetic kidney disease in patients with type 2 diabetes
    Ji Eun Jun, Min Sun Choi, Jae Hyeon Kim
    Diabetes Research and Clinical Practice.2022; 184: 109181.     CrossRef
  • Lipidomic Analysis Reveals the Protection Mechanism of GLP-1 Analogue Dulaglutide on High-Fat Diet-Induced Chronic Kidney Disease in Mice
    Martin Ho Yin Yeung, Ka Long Leung, Lai Yuen Choi, Jung Sun Yoo, Susan Yung, Pui-Kin So, Chi-Ming Wong
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • GLP-1 receptor agonists in diabetic kidney disease: current evidence and future directions
    Ji Hee Yu, So Young Park, Da Young Lee, Nan Hee Kim, Ji A Seo
    Kidney Research and Clinical Practice.2022; 41(2): 136.     CrossRef
  • Evolving Type 2 diabetes management focuses on clinical outcomes
    Caroline Fenton, Connie Kang
    Drugs & Therapy Perspectives.2022; 38(4): 165.     CrossRef
  • Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease
    Chan-Young Jung, Tae-Hyun Yoo
    Diabetes & Metabolism Journal.2022; 46(2): 181.     CrossRef
  • Critical shear stress of red blood cells as a novel integrated biomarker for screening chronic kidney diseases in cases of type 2 diabetes
    Il Rae Park, Jimi Choi, Eun Young Ha, Seung Min Chung, Jun Sung Moon, Sehyun Shin, Sin Gon Kim, Kyu Chang Won
    Clinical Hemorheology and Microcirculation.2022; 81(4): 293.     CrossRef
  • Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells
    Donghee Kim, Ga-Young Nam, Eunhui Seo, Hee-Sook Jun
    Journal of Biomedical Science.2022;[Epub]     CrossRef
  • The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1
    Yuji Oe, Volker Vallon
    Kidney and Dialysis.2022; 2(2): 349.     CrossRef
  • Dapagliflozin for the treatment of chronic kidney disease
    Yu Kurata, Masaomi Nangaku
    Expert Review of Endocrinology & Metabolism.2022; 17(4): 275.     CrossRef
  • Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease
    Javier Donate-Correa, María Dolores Sanchez-Niño, Ainhoa González-Luis, Carla Ferri, Alberto Martín-Olivera, Ernesto Martín-Núñez, Beatriz Fernandez-Fernandez, Víctor G Tagua, Carmen Mora-Fernández, Alberto Ortiz, Juan F Navarro-González
    Clinical Kidney Journal.2022; 15(12): 2200.     CrossRef
  • Cyproheptadine, a SET7/9 inhibitor, reduces hyperglycaemia-induced ER stress alleviating inflammation and fibrosis in renal tubular epithelial cells
    Himanshu Sankrityayan, Ajinath Kale, Vishwadeep Shelke, Anil Bhanudas Gaikwad
    Archives of Physiology and Biochemistry.2022; : 1.     CrossRef
  • Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
    Debra Dorotea, Songling Jiang, Eun Seon Pak, Jung Beom Son, Hwan Geun Choi, Sung-Min Ahn, Hunjoo Ha
    Experimental & Molecular Medicine.2022; 54(8): 1086.     CrossRef
  • Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics
    Nam Hoon Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(4): 543.     CrossRef
  • Effect of once-weekly dulaglutide on renal function in patients with chronic kidney disease
    Sungmin Kim, Jung Nam An, Young Rim Song, Sung Gyun Kim, Hyung Seok Lee, AJin Cho, Jwa-Kyung Kim, Tomislav Bulum
    PLOS ONE.2022; 17(8): e0273004.     CrossRef
  • Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives
    Daniela Maria Tanase, Evelina Maria Gosav, Madalina Ioana Anton, Mariana Floria, Petronela Nicoleta Seritean Isac, Loredana Liliana Hurjui, Claudia Cristina Tarniceriu, Claudia Florida Costea, Manuela Ciocoiu, Ciprian Rezus
    Biomolecules.2022; 12(9): 1227.     CrossRef
  • Preventive and healing effect of high dosing grape seed flour on CKD patients of various stages and aetiologies
    Wiem Bejaoui, Mohamed Mahmoudi, Kamel Charradi, Monia Abbes-Belhadj, Habib Boukhalfa, Mossadok Ben-Attia, Ferid Limam, Ezzedine Aouani
    Biomarkers.2022; 27(8): 795.     CrossRef
  • Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics
    Miyesaier Abudureyimu, Xuanming Luo, Xiang Wang, James R Sowers, Wenshuo Wang, Junbo Ge, Jun Ren, Yingmei Zhang, Wei-Ping Jia
    Journal of Molecular Cell Biology.2022;[Epub]     CrossRef
  • Recent Advances in the Emerging Therapeutic Strategies for Diabetic Kidney Diseases
    Wei Huang, Yi-Yuan Chen, Zi-Qi Li, Fang-Fang He, Chun Zhang
    International Journal of Molecular Sciences.2022; 23(18): 10882.     CrossRef
  • Serum isthmin-1 levels are positively and independently correlated with albuminuria in patients with type 2 diabetes mellitus
    Chuan Wang, Mingyue Xu, Ruiying Feng, Lei Zhang, Xiaofei Yin, Ruoqi Feng, Kai Liang, Jinbo Liu
    BMJ Open Diabetes Research & Care.2022; 10(5): e002972.     CrossRef
  • hucMSC-sEVs-Derived 14-3-3ζ Serves as a Bridge between YAP and Autophagy in Diabetic Kidney Disease
    Siqi Yin, Wanzhu Liu, Cheng Ji, Yuan Zhu, Yunjie Shan, Zixuan Zhou, Wenya Chen, Leilei Zhang, Zixuan Sun, Wenqin Zhou, Hui Qian, Chaoliang Tang
    Oxidative Medicine and Cellular Longevity.2022; 2022: 1.     CrossRef
  • Adenosine receptors as emerging therapeutic targets for diabetic kidney disease
    Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha
    Kidney Research and Clinical Practice.2022; 41(Suppl 2): S74.     CrossRef
  • REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
    Siddharth Sunilkumar, Esma I. Yerlikaya, Allyson L. Toro, William P. Miller, Han Chen, Kebin Hu, Scot R. Kimball, Michael D. Dennis
    Diabetes.2022; 71(11): 2412.     CrossRef
  • The Role of Hypoxia-Inducible Factor-1 Alpha in Renal Disease
    Huixia Liu, Yujuan Li, Jing Xiong
    Molecules.2022; 27(21): 7318.     CrossRef
  • Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease
    Anna M. Drake, Melinda T. Coughlan, Claus T. Christophersen, Matthew Snelson
    Nutrients.2022; 14(21): 4547.     CrossRef
  • Aggravated renal fibrosis is positively associated with the activation of HMGB1-TLR2/4 signaling in STZ-induced diabetic mice
    Yan Yuan, Yuanxia Liu, Mengyao Sun, Huijing Ye, Yuchen Feng, Zhenzhen Liu, Lingyu Pan, Hongbo Weng
    Open Life Sciences.2022; 17(1): 1451.     CrossRef
  • Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids
    Jessica L. Davis, Ciaran Kennedy, Shane Clerkin, Niall J. Treacy, Thomas Dodd, Catherine Moss, Alison Murphy, Derek P. Brazil, Gerard Cagney, Dermot F. Brougham, Rabi Murad, Darren Finlay, Kristiina Vuori, John Crean
    Communications Biology.2022;[Epub]     CrossRef
  • Oxidized Albumin: Evaluation of Oxidative Stress as a Marker for the Progression of Kidney Disease
    Hiroshi Watanabe
    Biological and Pharmaceutical Bulletin.2022; 45(12): 1728.     CrossRef
  • Whether Renal Pathology Is an Independent Predictor for End-Stage Renal Disease in Diabetic Kidney Disease Patients with Nephrotic Range Proteinuria: A Biopsy-Based Study
    Tingli Wang, Junlin Zhang, Yiting Wang, Lijun Zhao, Yucheng Wu, Honghong Ren, Yutong Zou, Rui Zhang, Huan Xu, Zhonglin Chai, Mark Cooper, Jie Zhang, Fang Liu
    Journal of Clinical Medicine.2022; 12(1): 88.     CrossRef
  • What’s New in the Molecular Mechanisms of Diabetic Kidney Disease: Recent Advances
    Kimio Watanabe, Emiko Sato, Eikan Mishima, Mariko Miyazaki, Tetsuhiro Tanaka
    International Journal of Molecular Sciences.2022; 24(1): 570.     CrossRef
  • Clinical efficacy and safety of astragalus injection combined with ACEI/ARB in the treatment of diabetic kidney disease: Protocol for a systematic review and meta-analysis
    Zhiyue Zhu, Qi Zhang, Le Liu, Pengjie Bao, Shilin Liu, Chaoqun Song, Wenbo Yang, Zheng Nan
    Medicine.2022; 101(49): e31490.     CrossRef
  • Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells
    Donghee Kim, Jayeon Cheon, Haelim Yoon, Hee-Sook Jun, Evangelia Dounousi
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control
    Tomoaki Takata, Hajime Isomoto
    International Journal of Molecular Sciences.2021; 22(9): 4374.     CrossRef
  • HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
    Kiichi Hirota
    Biomedicines.2021; 9(5): 468.     CrossRef
  • Nephropathie bei Diabetes
    Roland E. Schmieder
    CardioVasc.2021; 21(3): 31.     CrossRef
  • Clinical Predictors of Nondiabetic Kidney Disease in Patients with Diabetes: A Single-Center Study
    Francesco Fontana, Rossella Perrone, Francesco Giaroni, Gaetano Alfano, Silvia Giovanella, Giulia Ligabue, Riccardo Magistroni, Gianni Cappelli, Udeme Ekrikpo
    International Journal of Nephrology.2021; 2021: 1.     CrossRef
  • Activated Histone Acetyltransferase p300/CBP-Related Signalling Pathways Mediate Up-Regulation of NADPH Oxidase, Inflammation, and Fibrosis in Diabetic Kidney
    Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea
    Antioxidants.2021; 10(9): 1356.     CrossRef
  • Plasma and urine biomarkers in chronic kidney disease: closer to clinical application
    Azadeh Zabetian, Steven G. Coca
    Current Opinion in Nephrology & Hypertension.2021; 30(6): 531.     CrossRef
  • Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy
    Fanrui Meng, Yukai Cao, Mir Hassan Khoso, Kai Kang, Guiping Ren, Wei Xiao, Deshan Li
    Archives of Biochemistry and Biophysics.2021; 713: 109063.     CrossRef
  • Mineralocorticoid Receptor Antagonists in Diabetic Kidney Disease
    Daiji Kawanami, Yuichi Takashi, Yoshimi Muta, Naoki Oda, Dai Nagata, Hiroyuki Takahashi, Makito Tanabe
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules
    Aleksandra Owczarek, Katarzyna B. Gieczewska, Robert Jarzyna, Zuzanna Frydzinska, Katarzyna Winiarska
    International Journal of Molecular Sciences.2021; 22(24): 13299.     CrossRef
  • The effect of modern hypoglycemic therapy on the course of chronic kidney disease in patients with type 2 diabetes mellitus
    V.I. Katerenchuk
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2021; 17(8): 624.     CrossRef
Sulwon Lecture 2017
The Role of Advanced Glycation End Products in Diabetic Vascular Complications
Sang Youl Rhee, Young Seol Kim
Diabetes Metab J. 2018;42(3):188-195.   Published online May 31, 2018
  • 9,398 View
  • 160 Download
  • 156 Web of Science
  • 155 Crossref
AbstractAbstract PDFPubReader   

In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.


Citations to this article as recorded by  
  • Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia‐derived neuroinflammation
    Xiaoyan Zhou, Yandong Zhu, Lin Gao, Yan Li, Hui Li, Chengyu Huang, Yan Liu, Ankang Hu, Changjiang Ying, Yuanjian Song
    CNS Neuroscience & Therapeutics.2024;[Epub]     CrossRef
  • Homeopathic Formulations of Syzygium jambolanum Alleviate Glycation-Mediated Structural and Functional Modifications of Albumin: Evaluation through Multi-Spectroscopic and Microscopic Approaches
    Nilima S. Bangar, Selvan Ravindran, Shamim A. Shaikh, Nilesh Shah, Rashmi S. Tupe
    Homeopathy.2024; 113(02): 098.     CrossRef
  • Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
    Dharmsheel Shrivastav, Desh Deepak Singh
    World Journal of Clinical Cases.2024; 12(3): 525.     CrossRef
  • Unraveling the Link between Ιnsulin Resistance and Bronchial Asthma
    Konstantinos Bartziokas, Andriana I. Papaioannou, Fotios Drakopanagiotakis, Evanthia Gouveri, Nikolaos Papanas, Paschalis Steiropoulos
    Biomedicines.2024; 12(2): 437.     CrossRef
  • Comparison of metabolic fate, target organs, and microbiota interactions of free and bound dietary advanced glycation end products
    Xiaojin Yuan, Chenxi Nie, Huicui Liu, Qingyu Ma, Bo Peng, Min Zhang, Zhifei Chen, Juxiu Li
    Critical Reviews in Food Science and Nutrition.2023; 63(19): 3612.     CrossRef
  • Advanced glycation end products: Key mediator and therapeutic target of cardiovascular complications in diabetes
    Savita Bansal, Archana Burman, Asok Kumar Tripathi
    World Journal of Diabetes.2023; 14(8): 1146.     CrossRef
  • Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review
    Vahid Maleki, Sepideh Abbaszadeh, Seyyed Morteza Seyyed Shoura, Asma Sohrabnavi, Mojtaba Sepandi, Maryam Taghdir
    Clinical and Experimental Pharmacology and Physiology.2023; 50(2): 121.     CrossRef
  • Piperine mitigates aortic vasculopathy in streptozotocin-diabetic rats via targeting TXNIP-NLRP3 signaling
    Fatma M. Amin, George S.G. Shehatou, Manar A. Nader, Rania R. Abdelaziz
    Life Sciences.2023; 314: 121275.     CrossRef
  • Endothelial-to-mesenchymal transition: An underappreciated mediator of diabetic complications
    Eric Wang, Honglin Wang, Subrata Chakrabarti
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Detection of Advanced Glycosylation End Products in the Cornea Based on Molecular Fluorescence and Machine Learning
    Jianming Zhu, Sifeng Lian, Haochen Zhong, Ruiyang Sun, Zhenbang Xiao, Hua Li
    Biosensors.2023; 13(2): 170.     CrossRef
    A. A. Spasov, O. N. Zhukovskaya, A. I. Rashchenko, A. A. Brigadirova, R. A. Litvinov, N. A. Gurova, A. V. Smirnov, N. G. Pan’shin, H. S.A. Abbas, A. S. Morkovnik
    Pharmacy & Pharmacology.2023; 10(6): 549.     CrossRef
  • Dietary advanced glycation end products (dAGEs): An insight between modern diet and health
    Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li
    Food Chemistry.2023; 415: 135735.     CrossRef
  • Predictive Value of Noninvasive Peripheral Atherosclerosis Measurement for Coronary Artery Disease in Patients with Long T2DM Duration
    Wanjiao Chen, Li Wang, Bin Hu, Ying Zheng, Shuya Zhang, Zhong Zhou, Yifeng Mai
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 1075.     CrossRef
  • Cereal polyphenols inhibition mechanisms on advanced glycation end products and regulation on type 2 diabetes
    Lezhen Dong, Ying Li, Qin Chen, Yahui Liu, Zufang Wu, Daodong Pan, Ning Yan, Lianliang Liu
    Critical Reviews in Food Science and Nutrition.2023; : 1.     CrossRef
  • Artemisinin attenuates type 2 diabetic cardiomyopathy in rats through modulation of AGE-RAGE/HMGB-1 signaling pathway
    Eman A. E. Farrag, Maha O. Hammad, Sally M. Safwat, Shereen Hamed, Doaa Hellal
    Scientific Reports.2023;[Epub]     CrossRef
  • Glycemic Control and Adverse Clinical Outcomes in Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus: Results from KNOW-CKD
    Ga Young Heo, Hee Byung Koh, Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Jayoun Kim, Soo Wan Kim, Yeong Hoon Kim, Su Ah Sung, Kook-Hwan Oh, Seung Hyeok Han
    Diabetes & Metabolism Journal.2023; 47(4): 535.     CrossRef
  • Chronic sildenafil citrate use decreases retinal vascular endothelial growth factor expression in diabetic rats: a pilot study
    Osama A. Sorour, Elsayed Nassar, Naglaa Sarhan, Noha El-Anwar, Reem A ElKholy, Dina M. Tahoon, Aalaa Sweilam, Dina Tadros
    International Journal of Retina and Vitreous.2023;[Epub]     CrossRef
  • Pathophysiology of diabetic kidney disease and autophagy: A review
    Jiawei Yu, Yan Liu, Hongjie Li, Peirong Zhang
    Medicine.2023; 102(30): e33965.     CrossRef
  • Evidence that methylglyoxal and receptor for advanced glycation end products are implicated in bladder dysfunction of obese diabetic ob/ob mice
    Akila L. Oliveira, Matheus L. Medeiros, Ana Carolina Ghezzi, Gabriel Alonso dos Santos, Glaucia Coelho Mello, Fabíola Z. Mónica, Edson Antunes
    American Journal of Physiology-Renal Physiology.2023; 325(4): F436.     CrossRef
  • Effects of Advanced Glycation End Products via Oxidative Stress on Beta Cells: Insights from in vitro and in vivo Studies and Update on Emerging Therapies
    Ioanna A. Anastasiou, Konstantinos N. Tentolouris, Vaia Lambadiari, Ioanna Eleftheriadou, Maria Tektonidou, Nikolaos Tentolouris
    Mini-Reviews in Medicinal Chemistry.2023; 23(21): 2041.     CrossRef
  • Carvedilol improves heart rate variability indices, biomarkers but not cardiac nerve density in streptozotocin-induced T2DM model of diabetic cardiac autonomic neuropathy
    Olawale Mathias Akinlade, Bamidele Owoyele, Olufemi Ayodele Soladoye
    Journal of Basic and Clinical Physiology and Pharmacology.2022; 33(2): 213.     CrossRef
  • Cerebral small vessel disease: A glymphopathy?
    Helene Benveniste, Maiken Nedergaard
    Current Opinion in Neurobiology.2022; 72: 15.     CrossRef
  • Impact of glucose variability on coronary plaque vulnerability in patients with dysglycemia: A whole coronary analysis with multislice computed tomography
    Tsuyoshi Ito, Kosuke Nakasuka, Hiroshi Fujita, Masashi Yokoi, Takafumi Nakayama, Tomonori Sugiura, Nobuyuki Ohte, Yoshihiro Seo
    Journal of Cardiology.2022; 79(1): 58.     CrossRef
  • Inhibition of Advanced Glycation End Product Formation in Rat Tail Tendons by Polydatin and p-Coumaric acid: an In Vitro Study
    Gopika Selvakumar, Dhanalakshmi Venu, Iyappan Kuttalam, Suguna Lonchin
    Applied Biochemistry and Biotechnology.2022; 194(1): 339.     CrossRef
  • Anti-α-Glucosidase and Antiglycation Activities of α-Mangostin and New Xanthenone Derivatives: Enzymatic Kinetics and Mechanistic Insights through In Vitro Studies
    Francine Medjiofack Djeujo, Valeria Francesconi, Maddalena Gonella, Eugenio Ragazzi, Michele Tonelli, Guglielmina Froldi
    Molecules.2022; 27(2): 547.     CrossRef
  • Metabolic and Metabo-Clinical Signatures of Type 2 Diabetes, Obesity, Retinopathy, and Dyslipidemia
    Noha A. Yousri, Karsten Suhre, Esraa Yassin, Alya Al-Shakaki, Amal Robay, Maha Elshafei, Omar Chidiac, Steven C. Hunt, Ronald G. Crystal, Khalid A. Fakhro
    Diabetes.2022; 71(2): 184.     CrossRef
  • An Insight into Potential Pharmacotherapeutic Agents for Painful Diabetic Neuropathy
    Zunaira Qureshi, Murtaza Najabat Ali, Minahil Khalid, Nikolaos Papanas
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • Glycation: A connecting link between diabetes and COVID-19
    SnehaB Bansode, RakeshS Joshi, AshokP Giri, MaheshJ Kulkarni
    Chronicle of Diabetes Research and Practice.2022; 1(1): 35.     CrossRef
  • Controlled Formation of Pyrazines: Inhibition by Ellagic Acid Interaction with N-(1-Deoxy-d-xylulos-1-yl)-glycine and Promotion through Ellagic Acid Oxidation
    Ziyan Wang, Heping Cui, Mengyu Ma, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho
    Journal of Agricultural and Food Chemistry.2022; 70(5): 1618.     CrossRef
  • The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
    Matthew Snelson, Elisa Lucut, Melinda T. Coughlan
    International Journal of Molecular Sciences.2022; 23(3): 1766.     CrossRef
  • Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum
    Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou
    Molecules.2022; 27(5): 1457.     CrossRef
  • Alterations in pro- and anti-inflammatory mediators are involved in microvascular dysfunction in postmenopausal women with type 2 diabetes mellitus
    A.P. Jarrete, L.T. Giollo-Junior, J.F. Vilela-Martin, I.P. Novais, M.A. Delbin, A. Zanesco
    Brazilian Journal of Medical and Biological Research.2022;[Epub]     CrossRef
  • Is dietary intake of advanced glycation end products associated with mortality among adults with diabetes?
    Alain K. Koyama, Meda E. Pavkov, Yanjue Wu, Karen R. Siegel
    Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(6): 1402.     CrossRef
  • Antidiabetic and antiglycating potential of chrysin is enhanced after nano formulation: An in vitro approach
    Asimah Khalid, Imrana Naseem
    Journal of Molecular Structure.2022; 1261: 132906.     CrossRef
  • The Role of Advanced Glycation End Products and Its Soluble Receptor in Kidney Diseases
    Mieke Steenbeke, Reinhart Speeckaert, Stéphanie Desmedt, Griet Glorieux, Joris R. Delanghe, Marijn M. Speeckaert
    International Journal of Molecular Sciences.2022; 23(7): 3439.     CrossRef
  • Nɛ-(carboxymethyl)lysine, Available Lysine, and Volatile Compound Profile of Biscuits Enriched with Grape by-Product During Storage
    Sylwia Mildner-Szkudlarz, Aleksander Siger, Krzysztof Przygoński, Elżbieta Radziejewska-Kubzdela, Renata Zawirska-Wojtasiak
    Plant Foods for Human Nutrition.2022; 77(2): 190.     CrossRef
  • Chlorophytum alismifolium mitigates microvascular complications of type 2 diabetes mellitus: the involvement of oxidative stress and aldose reductase
    Abdulhakim Abubakar, Abdullahi Balarabe Nazifi, Idris Mohammed Maje, Yusuf Tanko, Joseph Akpojo Anuka, Ezzeldin Mukthar Abdurahman
    Drug Metabolism and Personalized Therapy.2022; 37(1): 69.     CrossRef
  • A brief review of vitamin D as a potential target for the regulation of blood glucose and inflammation in diabetes-associated periodontitis
    Cheng Dong, Xuzhi Hu, Alok Shiomurti Tripathi
    Molecular and Cellular Biochemistry.2022; 477(9): 2257.     CrossRef
  • Cerebral Microvascular Senescence and Inflammation in Diabetes
    Ashley Phoenix, Raghavendar Chandran, Adviye Ergul
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Effects of natural dihydrochalcones in sweet tea (Lithocarpus polystachyus) on diabetes: a systematical review and meta-analysis of animal studies
    Xue-Min Chen, Wei-Qi Yang, Xue Wang, Chong Chen, Zheng-Ming Qian, Shu-Mei Wang, Dan Tang
    Food & Function.2022; 13(11): 5899.     CrossRef
  • Investigation of DHA-Induced Regulation of Redox Homeostasis in Retinal Pigment Epithelium Cells through the Combination of Metabolic Imaging and Molecular Biology
    Giada Bianchetti, Maria Elisabetta Clementi, Beatrice Sampaolese, Cassandra Serantoni, Alessio Abeltino, Marco De Spirito, Shlomo Sasson, Giuseppe Maulucci
    Antioxidants.2022; 11(6): 1072.     CrossRef
  • Almond and date fruits enhance antioxidant status and have erectogenic effect: Evidence from in vitro and in vivo studies
    Adeniyi A. Adebayo, Ganiyu Oboh, Ayokunle O. Ademosun
    Journal of Food Biochemistry.2022;[Epub]     CrossRef
  • Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
    Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
    Pharmacological Research.2022; 182: 106358.     CrossRef
  • Advanced Glycation End Products and Their Effect on Vascular Complications in Type 2 Diabetes Mellitus
    Jeongmin Lee, Jae-Seung Yun, Seung-Hyun Ko
    Nutrients.2022; 14(15): 3086.     CrossRef
  • Interaction behavior between glycated human serum albumin and metformin in the presence of silver nanoparticles: a combination study of spectroscopic, calorimetric and molecular dynamic
    Sara Ezazi-Toroghi, Sana Abdul-Jabbar Ali, Dmitry Olegovich Bokov, Maryam Dareini, Malihe Bahadori, Parisa Mokaberi, Zeinab Amiri-Tehranizadeh, Mohammad Reza Saberi, Jamshidkhan Chamani
    Journal of the Iranian Chemical Society.2022; 19(12): 4569.     CrossRef
  • The AGEs/RAGE Transduction Signaling Prompts IL-8/CXCR1/2-Mediated Interaction between Cancer-Associated Fibroblasts (CAFs) and Breast Cancer Cells
    Maria Francesca Santolla, Marianna Talia, Francesca Cirillo, Domenica Scordamaglia, Salvatore De Rosis, Asia Spinelli, Anna Maria Miglietta, Bruno Nardo, Gianfranco Filippelli, Ernestina Marianna De Francesco, Antonino Belfiore, Rosamaria Lappano, Marcell
    Cells.2022; 11(15): 2402.     CrossRef
  • Association study of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with diabetic retinopathy in Egyptian patients: crosslinks with angiogenic, inflammatory, and anti-inflammatory markers
    Mahmoud K. Mohamed, Azza A. Atef, Leqaa A. Moemen, Amira A. Abdel Azeem, Islam A. Mohalhal, Alshaimaa M. Taha
    Journal of Genetic Engineering and Biotechnology.2022; 20(1): 122.     CrossRef
  • The association between advanced glycation end products (AGEs) and ABC (hemoglobin A1C, blood pressure, and low-density lipoprotein cholesterol) control parameters among patients with type 2 diabetes mellitus
    Mohaddeseh Rezaei, Soghra Rabizadeh, Maryam Mirahmad, Minoo Sadat Hajmiri, Manouchehr Nakhjavani, Mahboobeh Hemmatabadi, Nooshin Shirzad
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Endogenous advanced glycation end products in the pathogenesis of chronic diabetic complications
    Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • Antiglycation potential of plant based TiO2 nanoparticle in D‐ribose glycated BSA in vitro
    Fahaad Alenazi, Mohd Saleem, Azharuddin Sajid Syed Khaja, Mubashir Zafar, Mohammed Salem Alharbi, Turki Al Hagbani, Mohd Yasir Khan, Waseem Ahmad, Saheem Ahmad
    Cell Biochemistry and Function.2022; 40(7): 784.     CrossRef
    О.V. Tkachuk, S.S. Tkachuk, М.А. Povar, S.I. Anokhina, O.V. Yasinska, S.N. Vadziuk
    Fiziolohichnyĭ zhurnal.2022; 68(4): 40.     CrossRef
  • Impact of High Aspartame and High Fructose Diet on Vascular Reactivity, Glucose Metabolism and Liver Structure in Diabetic Rats
    Adel Shalaby, Marwa Al-Gholam, Safa Elfiky, Ghada Elgarawany
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 1433.     CrossRef
  • KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect
    Jiun-Chi Huang, Szu-Chia Chen, Wei-An Chang, Wei-Wen Hung, Ping-Hsun Wu, Ling-Yu Wu, Jer-Ming Chang, Ya-Ling Hsu, Yi-Chun Tsai
    International Journal of Molecular Sciences.2022; 23(19): 11723.     CrossRef
  • Comparative Evaluation of the Antiglycation and Anti-α-Glucosidase Activities of Baicalein, Baicalin (Baicalein 7-O-Glucuronide) and the Antidiabetic Drug Metformin
    Guglielmina Froldi, Francine Medjiofack Djeujo, Nadia Bulf, Emma Caparelli, Eugenio Ragazzi
    Pharmaceutics.2022; 14(10): 2141.     CrossRef
  • Reduced coupling between the global blood-oxygen-level-dependent signal and cerebrospinal fluid inflow is associated with the severity of small vessel disease
    Yao Zhang, Ruiting Zhang, Shuyue Wang, Hui Hong, Yeerfan Jiaerken, Kaicheng Li, Qingze Zeng, Xiao Luo, Xinfeng Yu, Minming Zhang, Peiyu Huang
    NeuroImage: Clinical.2022; 36: 103229.     CrossRef
  • To Investigate the Protective Effect and Mechanism of Isoorientin on Aortic in T2DM Macrovascular Disease Mice
    娟 谭
    Advances in Clinical Medicine.2022; 12(10): 9140.     CrossRef
  • Low grade intravascular hemolysis associates with peripheral nerve injury in type 2 diabetes
    Sylvain Le Jeune, Sihem Sadoudi, Dominique Charue, Salwa Abid, Jean-Michel Guigner, Dominique Helley, Hélène Bihan, Camille Baudry, Hélène Lelong, Tristan Mirault, Eric Vicaut, Robin Dhote, Jean-Jacques Mourad, Chantal M. Boulanger, Olivier P. Blanc-Brude
    PLOS ONE.2022; 17(10): e0275337.     CrossRef
  • Vascular contributions to cognitive impairment/dementia in diabetes: role of endothelial cells and pericytes
    Mia Edgerton-Fulton, Adviye Ergul
    American Journal of Physiology-Cell Physiology.2022; 323(4): C1177.     CrossRef
  • The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats
    Khulood Hussein
    Pharmacophore.2022; 13(3): 98.     CrossRef
  • Aqueous extract of Massularia acuminata exerts erectogenic effect by modulating critical enzymes and hormones in streptozotocin‐induced erectile dysfunction in rats
    Stephen Adeniyi Adefegha, Ganiyu Oboh, Abraham Olanrewaju Adedipe
    Andrologia.2022;[Epub]     CrossRef
  • The Synthetic Flavonoid Hidrosmin Improves Endothelial Dysfunction and Atherosclerotic Lesions in Diabetic Mice
    Luna Jiménez-Castilla, Lucas Opazo-Ríos, Gema Marin-Royo, Macarena Orejudo, Raquel Rodrigues-Diez, Constanza Ballesteros-Martínez, Manuel Soto-Catalán, Teresa Caro-Ordieres, Inés Artaiz, Tatiana Suarez-Cortés, Arturo Zazpe, Gonzalo Hernández, Marcelino Co
    Antioxidants.2022; 11(12): 2499.     CrossRef
  • Protective effects of Vitex pseudo-negundo leaves on diabetic-induced nephropathy in rats
    Hasan Rezaei Seresht, Esrafil Mansouri, Mahsa Daei Milani, Bahareh Vahidiyanfar, Arash Ramezanpour Shahi, Mohammad Javad Namazi, Hossein Moallaei, Maryam Latifnia, Mojtaba Fattahi Abdizadeh
    Journal of Basic and Clinical Physiology and Pharmacology.2021;[Epub]     CrossRef
  • Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status
    Aurelia Magdalena Pisoschi, Aneta Pop, Florin Iordache, Loredana Stanca, Gabriel Predoi, Andreea Iren Serban
    European Journal of Medicinal Chemistry.2021; 209: 112891.     CrossRef
  • Diabetes, insulin resistance, and asthma: a review of potential links
    Tianshi David Wu
    Current Opinion in Pulmonary Medicine.2021; 27(1): 29.     CrossRef
  • Translational insight into prothrombotic state and hypercoagulation in nonalcoholic fatty liver disease
    Alessandro Ciavarella, Davide Gnocchi, Carlo Custodero, Gennaro Mariano Lenato, Giorgio Fiore, Carlo Sabbà, Antonio Mazzocca
    Thrombosis Research.2021; 198: 139.     CrossRef
  • A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds
    Shehwaz Anwar, Shifa Khan, Ahmad Almatroudi, Amjad Ali Khan, Mohammed A. Alsahli, Saleh A. Almatroodi, Arshad Husain Rahmani
    Molecular Biology Reports.2021; 48(1): 787.     CrossRef
  • Acetoacetate enhancement of glucose mediated DNA glycation
    M. Bagherzadeh-Yazdi, M. Bohlooli, M. Khajeh, F. Ghamari, M. Ghaffari-Moghaddam, N. Poormolaie, A. Khatibi, P. Hasanein, N. Sheibani
    Biochemistry and Biophysics Reports.2021; 25: 100878.     CrossRef
  • Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
    Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L. Corrêa-Giannella, Mario Laut
    Clinical Science.2021; 135(1): 19.     CrossRef
  • Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties
    Christopher A. Rock, Samuel Keeney, Andrey Zakharchenko, Hajime Takano, David A. Spiegel, Abba M. Krieger, Giovanni Ferrari, Robert J. Levy
    Acta Biomaterialia.2021; 123: 275.     CrossRef
  • Intestinal microbiota and diabetic kidney diseases: the Role of microbiota and derived metabolites inmodulation of renal inflammation and disease progression
    C.M. Mosterd, M. Kanbay, B.J.H. van den Born, D.H. van Raalte, E. Rampanelli
    Best Practice & Research Clinical Endocrinology & Metabolism.2021; 35(3): 101484.     CrossRef
  • Attenuation of protein glycation by functional polyphenolics of dragon fruit (Hylocereus polyrhizus); an in vitro and in silico evaluation
    Guna Ravichandran, Dinesh Kumar Lakshmanan, Selvakumar Murugesan, Abbirami Elangovan, Namakkal S. Rajasekaran, Sivasudha Thilagar
    Food Research International.2021; 140: 110081.     CrossRef
  • Sex May Modulate the Effects of Combined Polyphenol Extract and L-citrulline Supplementation on Ambulatory Blood Pressure in Adults with Prehypertension: A Randomized Controlled Trial
    Cécile Vors, Maryka Rancourt-Bouchard, Charles Couillard, Iris Gigleux, Patrick Couture, Benoît Lamarche
    Nutrients.2021; 13(2): 399.     CrossRef
  • Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury
    Wiramon Rungratanawanich, Ying Qu, Xin Wang, Musthafa Mohamed Essa, Byoung-Joon Song
    Experimental & Molecular Medicine.2021; 53(2): 168.     CrossRef
  • Biological variation of glycated albumin, glucose and albumin in healthy Turkish subjects
    Osman Oğuz, Hilal Mercan, F. Sinem Hocaoglu-Emre
    Turkish Journal of Biochemistry.2021; 46(2): 197.     CrossRef
  • Platelet Indices and Its Association with Microvascular Complications Among Type 2 Diabetes Mellitus Patients in Northeast Ethiopia: A Cross-Sectional Study
    Mitku Mammo Taderegew, Gashaw Garedew Woldeamanuel, Mamo Solomon Emeria, Melkamu Tilahun, Getachew Yideg Yitbarek, Betregiorgis Zegeye
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 865.     CrossRef
  • Protective role of Clitoria ternatea L. flower extract on methylglyoxal-induced protein glycation and oxidative damage to DNA
    Poramin Chayaratanasin, Sirichai Adisakwattana, Thavaree Thilavech
    BMC Complementary Medicine and Therapies.2021;[Epub]     CrossRef
  • Phytochemicals against anti‐diabetic complications: targeting the advanced glycation end product signaling pathway
    Amna Parveen, Razia Sultana, Seung Min Lee, Tae Hun Kim, Sun Yeou Kim
    Archives of Pharmacal Research.2021; 44(4): 378.     CrossRef
  • Sesamin suppresses advanced glycation end products induced microglial reactivity using BV2 microglial cell line as a model
    Sasimol Udomruk, Benjawan Wudtiwai, Thuzar Hla Shwe, Thanyaluck Phitak, Peraphan Pothacharoen, Mattabhorn Phimphilai, Prachya Kongtawelert
    Brain Research Bulletin.2021; 172: 190.     CrossRef
  • The Role of Sarcopenic Obesity in Cancer and Cardiovascular Disease: A Synthesis of the Evidence on Pathophysiological Aspects and Clinical Implications
    Erika Aparecida Silveira, Rômulo Roosevelt da Silva Filho, Maria Claudia Bernardes Spexoto, Fahimeh Haghighatdoost, Nizal Sarrafzadegan, Cesar de Oliveira
    International Journal of Molecular Sciences.2021; 22(9): 4339.     CrossRef
  • Pterostilbene prevents methylglyoxal-induced cytotoxicity in endothelial cells by regulating glyoxalase, oxidative stress and apoptosis
    Dan Tang, Wei Xiao, Wen-Ting Gu, Zhi-Tong Zhang, Shu-Hong Xu, Zhi-Quan Chen, You-Hua Xu, Lu-Yong Zhang, Shu-Mei Wang, Hong Nie
    Food and Chemical Toxicology.2021; 153: 112244.     CrossRef
  • Therapeutic Potential of Polyphenols in the Management of Diabetic Neuropathy
    Md. Tanvir Kabir, Nuzhat Tabassum, Md. Sahab Uddin, Faissal Aziz, Tapan Behl, Bijo Mathew, Md. Habibur Rahman, Raushanara Akter, Abdur Rauf, Lotfi Aleya, Rajeev K Singla
    Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
  • EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress
    Roberta Giordo, Yusra M. A. Ahmed, Hilda Allam, Salah Abusnana, Lucia Pappalardo, Gheyath K. Nasrallah, Arduino Aleksander Mangoni, Gianfranco Pintus
    Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
  • Novel advances in inhibiting advanced glycation end product formation using natural compounds
    Qinghe Song, Junjun Liu, Liyuan Dong, Xiaolei Wang, Xiandang Zhang
    Biomedicine & Pharmacotherapy.2021; 140: 111750.     CrossRef
  • Inhibitory effect of Salvia coccinea on inflammatory responses through NF-κB signaling pathways in THP-1 cells and acute rat diabetes mellitus
    Arun Sudaramoorthy, Gobinath Shanmugam, Narkunaraja Shanmugam
    Acta Histochemica.2021; 123(5): 151735.     CrossRef
  • The effects of different accumulated pressure-time integral stimuli on plantar blood flow in people with diabetes mellitus
    Yijie Duan, Weiyan Ren, Liqiang Xu, Wenqiang Ye, Yih-Kuen Jan, Fang Pu
    BMC Musculoskeletal Disorders.2021;[Epub]     CrossRef
  • Piperine exhibits preventive and curative effect on erythrocytes membrane modifications and oxidative stress against in vitro albumin glycation
    Rashmi S. Tupe, Nilima Bangar, Akib Nisar, Amruta Kulkarni, Neena Sankhe, Rohan Chauhan, Nidhi Mistry, Shamim Shaikh
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • An Integrated Peptidomics and In Silico Approach to Identify Novel Anti-Diabetic Peptides in Parmigiano-Reggiano Cheese
    Serena Martini, Lisa Solieri, Alice Cattivelli, Valentina Pizzamiglio, Davide Tagliazucchi
    Biology.2021; 10(6): 563.     CrossRef
  • The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis
    Christos Chatzakis, Alexandros Sotiriadis, Evangelia Tsakmaki, Maria Papagianni, George Paltoglou, Konstantinos Dinas, George Mastorakos
    Nutrients.2021; 13(7): 2284.     CrossRef
  • Hydroxytyrosol Selectively Affects Non-Enzymatic Glycation in Human Insulin and Protects by AGEs Cytotoxicity
    Ivana Sirangelo, Margherita Borriello, Maria Liccardo, Marika Scafuro, Paola Russo, Clara Iannuzzi
    Antioxidants.2021; 10(7): 1127.     CrossRef
  • Tinospora cordifolia activates PPARγ pathway and mitigates glomerular and tubular cell injury in diabetic kidney disease
    Vikram Patial, Swati Katoch, Jyoti Chhimwal, Prithvi Pal Singh, Patil Shivprasad Suresh, Yogendra Padwad
    Phytomedicine.2021; 91: 153663.     CrossRef
  • Phloroglucinol prevents albumin glycation as well as diminishes ROS production, glycooxidative damage, nitrosative stress and inflammation in hepatocytes treated with high glucose
    Krzysztof Drygalski, Eliza Fereniec, Anna Zalewska, Adam Krętowski, Małgorzata Żendzian-Piotrowska, Mateusz Maciejczyk
    Biomedicine & Pharmacotherapy.2021; 142: 111958.     CrossRef
  • Advanced glycation end products (AGEs) and its receptor, RAGE, modulate age-dependent COVID-19 morbidity and mortality. A review and hypothesis
    Durai Sellegounder, Parisa Zafari, Misagh Rajabinejad, Mahdi Taghadosi, Pankaj Kapahi
    International Immunopharmacology.2021; 98: 107806.     CrossRef
  • Phytochemical Composition, Antiglycation, Antioxidant Activity and Methylglyoxal-Trapping Action of Brassica Vegetables
    Thavaree Thilavech, Marisa Marnpae, Kittana Mäkynen, Sirichai Adisakwattana
    Plant Foods for Human Nutrition.2021; 76(3): 340.     CrossRef
  • Chlorophytum alismifolium mitigates microvascular complications of type 2 diabetes mellitus: the involvement of oxidative stress and aldose reductase
    Abdulhakim Abubakar, Abdullahi Balarabe Nazifi, Idris Mohammed Maje, Yusuf Tanko, Joseph Akpojo Anuka, Ezzeldin Mukthar Abdurahman
    Drug Metabolism and Personalized Therapy.2021;[Epub]     CrossRef
  • Dietary advanced glycation end-products elicit toxicological effects by disrupting gut microbiome and immune homeostasis
    Yingjia Chen, Tai L. Guo
    Journal of Immunotoxicology.2021; 18(1): 93.     CrossRef
  • Antioxidant compounds of Kielmeyera coriacea Mart. with α-amylase, lipase and advanced glycation end-product inhibitory activities
    Allisson Benatti Justino, Eder C. Santana, Rodrigo Rodrigues Franco, Julia Silveira Queiroz, Heitor Cappato Guerra Silva, Joed Pires de Lima, André Lopes Saraiva, Mário Machado Martins, Sérgio Antônio Lemos de Morais, Alberto de Oliveira, Luiz Ricardo Gou
    Journal of Pharmaceutical and Biomedical Analysis.2021; 206: 114387.     CrossRef
  • Association of Novel Advanced Glycation End-Product (AGE10) with Complications of Diabetes as Measured by Enzyme-Linked Immunosorbent Assay
    Agnieszka Bronowicka-Szydełko, Małgorzata Krzystek-Korpacka, Małgorzata Gacka, Jadwiga Pietkiewicz, Urszula Jakobsche-Policht, Andrzej Gamian
    Journal of Clinical Medicine.2021; 10(19): 4499.     CrossRef
  • Glycyrrhizic Acid Scavenges Reactive Carbonyl Species and Attenuates Glycation-Induced Multiple Protein Modification: An In Vitro and In Silico Study
    Sahir Sultan Alvi, Rabia Nabi, Mohd. Shahnawaz Khan, Firoz Akhter, Saheem Ahmad, M. Salman Khan, Carla Tatone
    Oxidative Medicine and Cellular Longevity.2021; 2021: 1.     CrossRef
  • Effects of Psoralea corylifolia L. seed extract on AGEs‑induced cell proliferation and fibrotic factor expression in mesangial cells
    Hyunah Chung, Eunhui Seo, Hee-Sook Jun
    Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef
  • Skin Autofluorescence as a Novel and Noninvasive Technology for Advanced Glycation End Products in Diabetic Foot Ulcers: A Systematic Review and Meta-analysis
    Seshadri Reddy Varikasuvu, Saurabh Varshney, Harish Sulekar
    Advances in Skin & Wound Care.2021; 34(11): 1.     CrossRef
  • Characterization of the Oral Microbiome Among Children With Type 1 Diabetes Compared With Healthy Children
    Moti Moskovitz, Mira Nassar, Nadav Moriel, Avital Cher, Sarit Faibis, Diana Ram, David Zangen, Moran Yassour, Doron Steinberg
    Frontiers in Microbiology.2021;[Epub]     CrossRef
  • Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways
    Han-Kyul Nam, So-Ra Jeong, Min Cheol Pyo, Sang-Keun Ha, Mi-Hyun Nam, Kwang-Won Lee
    Biological and Pharmaceutical Bulletin.2021; 44(11): 1697.     CrossRef
  • A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations
    Tessa Keenan, Richard J. Spears, Saeed Akkad, Clare S. Mahon, Natasha E. Hatton, Julia Walton, Amanda Noble, Nicholas D. Yates, Christoph G. Baumann, Alison Parkin, Nathalie Signoret, Martin A. Fascione
    ACS Chemical Biology.2021; 16(11): 2387.     CrossRef
  • Skin Advanced Glycation End Products among Subjects with Type 2 Diabetes Mellitus with or without Distal Sensorimotor Polyneuropathy
    Stella Papachristou, Kalliopi Pafili, Grigorios Trypsianis, Dimitrios Papazoglou, Konstantinos Vadikolias, Nikolaos Papanas, Bernd Stratmann
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • Liver fibrosis indices are related to diabetic peripheral neuropathy in individuals with type 2 diabetes
    Kyuho Kim, Tae Jung Oh, Hyen Chung Cho, Yun Kyung Lee, Chang Ho Ahn, Bo Kyung Koo, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Scientific Reports.2021;[Epub]     CrossRef
  • Isolation of Anti-Diabetic Active Compounds from Benincasae Exocarpium and Development of Simultaneous Analysis by HPLC-PDA
    Hye Sung Ryu, Suk Jin Lee, Wan Kyunn Whang
    Molecules.2021; 27(1): 9.     CrossRef
  • Association of Oxidative Stress Markers with Vascular Stiffness Parameters in Patients with Diabetic Neuropathy
    Dominika Mačáková, Markéta Plchová, Lubica Cibičková, Ondřej Krystyník, David Karásek, Josef Zadrazil
    BioMed.2021; 2(1): 1.     CrossRef
  • Gly-LysPred: Identification of Lysine Glycation Sites in Protein Using Position Relative Features and Statistical Moments Via Chou’s 5 Step Rule
    Shaheena Khanum, Muhammad Adeel Ashraf, Asim Karim, Bilal Shoaib, Muhammad Adnan Khan, Rizwan Ali Naqvi, Kamran Siddique, Mohammed Alswaitti
    Computers, Materials & Continua.2021; 66(2): 2165.     CrossRef
  • Multiple fingerprint profiling for quality evaluation of polysaccharides and related biological activity analysis of Chinese patent drugs: Zishen Yutai Pills as a case study
    Hongyi Li, Jiliang Cao, Xu Wu, Yun Deng, Na Ning, Chunxian Geng, Ting Lei, Ruizhen Lin, Dingtao Wu, Shengpeng Wang, Peng Li, Yitao Wang
    Journal of Ethnopharmacology.2020; 260: 113045.     CrossRef
  • Association Between Continuous Glucose Monitoring-Derived Time in Range, Other Core Metrics, and Albuminuria in Type 2 Diabetes
    Jee Hee Yoo, Min Sun Choi, Jiyeon Ahn, Sung Woon Park, Yejin Kim, Kyu Yeon Hur, Sang-Man Jin, Gyuri Kim, Jae Hyeon Kim
    Diabetes Technology & Therapeutics.2020; 22(10): 768.     CrossRef
  • Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway
    Fatma M. Amin, Rania R. Abdelaziz, Mohamed F. Hamed, Manar A. Nader, George S.G. Shehatou
    Life Sciences.2020; 256: 117887.     CrossRef
  • Aliskiren – A promising antioxidant agent beyond hypertension reduction
    Saeed Alshahrani
    Chemico-Biological Interactions.2020; 326: 109145.     CrossRef
  • Glycation of fibronectin inhibits VEGF‐induced angiogenesis by uncoupling VEGF receptor‐2‐c‐Src crosstalk
    Tangting Chen, Jinling Dong, Haiyan Zhou, Xin Deng, Rong Li, Ni Chen, Mao Luo, Yongjie Li, Jianbo Wu, Liqun Wang
    Journal of Cellular and Molecular Medicine.2020; 24(16): 9154.     CrossRef
  • Association between carbonyl stress markers and the risk of acute coronary syndrome in patients with type 2 diabetes mellitus–A pilot study
    Sushmita Bora, Prashant S. Adole, Nissy Motupalli, Vinay R. Pandit, Kolar V. Vinod
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(6): 1751.     CrossRef
  • A biochemical & biophysical study on in-vitro anti-glycating potential of iridin against d-Ribose modified BSA
    Rabia Nabi, Sahir Sultan Alvi, Mohammad Shafi Shah, Saheem Ahmad, Mohammad Faisal, Abdulrahman A. Alatar, M. Salman Khan
    Archives of Biochemistry and Biophysics.2020; 686: 108373.     CrossRef
  • Esculin reduces P2X7 and reverses mitochondrial dysfunction in the renal cortex of diabetic rats
    R.S. Serralha, I.F. Rodrigues, A. Bertolini, D.Y. Lima, M. Nascimento, M.G. Mouro, G.R. Punaro, I. Visoná, A.M. Rodrigues, E.M.S. Higa
    Life Sciences.2020; 254: 117787.     CrossRef
  • Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes
    Francesca Iannantuoni, Aranzazu M. de Marañon, Zaida Abad-Jiménez, Francisco Canet, Pedro Díaz-Pozo, Sandra López-Domènech, Carlos Morillas, Milagros Rocha, Víctor M. Víctor
    Journal of Clinical Medicine.2020; 9(7): 2155.     CrossRef
  • Comparative Evaluation of Dental Implant Failure among Healthy and Well-Controlled Diabetic Patients—A 3-Year Retrospective Study
    Mohammed Ghazi Sghaireen, Abdulrahman A. Alduraywish, Kumar Chandan Srivastava, Deepti Shrivastava, Santosh R Patil, Selham Al Habib, May Hamza, Saifulizan Ab Rahman, Edward Lynch, Mohammad Khursheed Alam
    International Journal of Environmental Research and Public Health.2020; 17(14): 5253.     CrossRef
  • Allithiamine Alleviates Hyperglycaemia-Induced Endothelial Dysfunction
    Attila Biró, Arnold Markovics, Mónika Éva Fazekas, Gábor Fidler, Gábor Szalóki, Melinda Paholcsek, János Lukács, László Stündl, Judit Remenyik
    Nutrients.2020; 12(6): 1690.     CrossRef
  • Endothelial Dysfunction in Diabetic Retinopathy
    Fu Gui, Zhipeng You, Shuhua Fu, Hongxi Wu, Yulan Zhang
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Diabetes affects endothelial cell function and alters fibrin clot formation in a microvascular flow model: A pilot study
    Lorenz Jenny, Andreas Melmer, Markus Laimer, Elaissa T Hardy, Wilbur A Lam, Verena Schroeder
    Diabetes and Vascular Disease Research.2020; 17(1): 147916412090304.     CrossRef
  • Measures of lung function and their relationship with advanced glycation end-products
    Suneela Zaigham, Margaretha Persson, Amra Jujic, Sophia Frantz, Yan Borné, Andrei Malinovschi, Per Wollmer, Gunnar Engström
    ERJ Open Research.2020; 6(2): 00356-2019.     CrossRef
  • LSEC model of aging
    Laurent Grosse, Dmitry V. Bulavin
    Aging.2020; 12(11): 11152.     CrossRef
  • Mitochondrial superoxide/hydrogen peroxide: An emerging therapeutic target for metabolic diseases
    Jialong Yan, Jinyong Jiang, Lu He, Linxi Chen
    Free Radical Biology and Medicine.2020; 152: 33.     CrossRef
  • Hepatic fibrosis is associated with total proteinuria in Korean patients with type 2 diabetes
    Eugene Han, Yongin Cho, Kyung-won Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-wan Lee
    Medicine.2020; 99(33): e21038.     CrossRef
  • Cognitive impairments in type 2 diabetes, risk factors and preventive strategies
    Garima Sharma, Arti Parihar, Tanay Talaiya, Kirti Dubey, Bhagyesh Porwal, Mordhwaj S. Parihar
    Journal of Basic and Clinical Physiology and Pharmacology.2020;[Epub]     CrossRef
  • Recent Updates on Vascular Complications in Patients with Type 2 Diabetes Mellitus
    Chan-Hee Jung, Ji-Oh Mok
    Endocrinology and Metabolism.2020; 35(2): 260.     CrossRef
  • Pathophysiology of atherosclerosis: Association of risk factors and treatment strategies using plant‐based bioactive compounds
    Hina Sharif, Muhammad Sajid Hamid Akash, Kanwal Rehman, Kanwal Irshad, Imran Imran
    Journal of Food Biochemistry.2020;[Epub]     CrossRef
  • Purification and identification of buckwheat hull flavonoids and its comparative evaluation on antioxidant and cytoprotective activity in vitro
    Yang Cui, Ziying Zhao, Ziqi Liu, Junmei Liu, Chunhong Piao, Dailin Liu
    Food Science & Nutrition.2020; 8(7): 3882.     CrossRef
  • Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications
    Eleftheria Papachristoforou, Vaia Lambadiari, Eirini Maratou, Konstantinos Makrilakis, Celestino Sardu
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Comparing the incidence of major cardiovascular events and severe microvascular complications in patients with type 2 diabetes mellitus: A systematic review and meta-analysis
    Ying-Ying Zhu, Zu-Yao Yang, Ping Li, Xin-Ying Huang, Xue-Hong Zhang, Li-Nong Ji, Jin-Ling Tang
    World Journal of Meta-Analysis.2020; 8(5): 400.     CrossRef
  • Influence of melatonin on the kidneys of rats with experimental diabetes mellitus type 2
    A. V. Semenko, Y. V. Murdasov, S. V. Kirichenko, V. I. Zhyliuk, G. A. Ushakovа
    Regulatory Mechanisms in Biosystems.2020; 11(3): 384.     CrossRef
  • Diabetes and cardiovascular disease: inter-relation of risk factors and treatment
    Aman Sharma, Shweta Mittal, Rohan Aggarwal, Meenakshi K. Chauhan
    Future Journal of Pharmaceutical Sciences.2020;[Epub]     CrossRef
  • In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox
    Sebastiano Intagliata, Angelo Spadaro, Miriam Lorenti, Annamaria Panico, Edy A. Siciliano, Sabrina Barbagallo, Benito Macaluso, Shyam H. Kamble, Maria N. Modica, Lucia Montenegro
    Antioxidants.2020; 10(1): 12.     CrossRef
  • Blood–Nerve Barrier (BNB) Pathology in Diabetic Peripheral Neuropathy and In Vitro Human BNB Model
    Yukio Takeshita, Ryota Sato, Takashi Kanda
    International Journal of Molecular Sciences.2020; 22(1): 62.     CrossRef
  • Prediction of Antiglycation Activity by Calculating the Energies of Frontier Molecular Orbitals for New 4-Hydroxy-1,4-Dihydroazolo[5,1-c]-1,2,4-Triazines Used as an Example
    R. A. Litvinov, R. A. Drokin, D. D. Shamshina, M. Yu. Kalenova, L. E. Usmianova, E. A. Muraveva, P. M. Vasiliev, E. K. Voinkov, E. N. Ulomskiy, A. A. Spasov, V. L. Rusinov
    Russian Journal of Bioorganic Chemistry.2020; 46(6): 1278.     CrossRef
  • Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and sRAGE Be the Panacea?
    Chinedum Eleazu, Norsuhana Omar, Oon Zhi Lim, Boon Seng Yeoh, Nik Hazlina Nik Hussain, Mahaneem Mohamed
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Glucose Variability and Coronary Artery Disease
    Jinggang Xia, Chunlin Yin
    Heart, Lung and Circulation.2019; 28(4): 553.     CrossRef
  • Recent advances in the pathogenesis of microvascular complications in diabetes
    Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
    Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
  • Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health
    Vidhu Gill, Vijay Kumar, Kritanjali Singh, Ashok Kumar, Jong-Joo Kim
    Biomolecules.2019; 9(12): 888.     CrossRef
  • DeepGly: A Deep Learning Framework With Recurrent and Convolutional Neural Networks to Identify Protein Glycation Sites From Imbalanced Data
    Jingui Chen, Runtao Yang, Chengjin Zhang, Lina Zhang, Qian Zhang
    IEEE Access.2019; 7: 142368.     CrossRef
  • Lysophosphatidic Acid Signaling in Diabetic Nephropathy
    Jong Lee, Donghee Kim, Yoon Oh, Hee-Sook Jun
    International Journal of Molecular Sciences.2019; 20(11): 2850.     CrossRef
  • Vascular Inflammation Risk Factors in Retinal Disease
    Ileana Soto, Mark P. Krebs, Alaina M. Reagan, Gareth R. Howell
    Annual Review of Vision Science.2019; 5(1): 99.     CrossRef
  • Diabetes, a Contemporary Risk for Parkinson’s Disease: Epidemiological and Cellular Evidences
    Domenico Sergi, Justine Renaud, Nicola Simola, Maria-Grazia Martinoli
    Frontiers in Aging Neuroscience.2019;[Epub]     CrossRef
  • Advanced Glycation End Products Are Associated With Inflammation and Endothelial Dysfunction in HIV
    Vanessa El Kamari, Alicia Thomas, Lingpeng Shan, Abdus Sattar, Vincent Monnier, Scott K. Howell, Paul J. Beisswenger, Grace A. McComsey
    JAIDS Journal of Acquired Immune Deficiency Syndromes.2019; 81(2): e55.     CrossRef
  • 1,25-(OH)2D3 protects Schwann cells against advanced glycation end products-induced apoptosis through PKA-NF-κB pathway
    Shiqing Xu, Jing Li, Min Zhai, Xiaoqi Yao, Honglin Liu, Tingting Deng, Hanqing Cai, Wan Zhang, Wenjian Zhang, Jinning Lou, Liang Peng
    Life Sciences.2019; 225: 107.     CrossRef
  • Maize bran feruloylated oligosaccharides inhibited AGEs formation in glucose/amino acids and glucose/BSA models
    Junqing Huang, Jiayi Ren, Gabriel Tao, Yongsheng Chen, Shengwen Yao, Duoduo Han, Ruixia Qiu
    Food Research International.2019; 122: 443.     CrossRef
  • Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy
    Tingting Zeng, Xiaoyi Wang, Wei Wang, Qiling Feng, Guojuan Lao, Ying Liang, Chuan Wang, Jing Zhou, Yuying Chen, Jing Liu, Haiqi Gao, Biyun Lan, Yuxi Wu, Yuting Han, Yanyan Liu, Hongxing Chen, Liyi Liu, Chuan Yang, Li Yan, Meng Ren, Kan Sun
    Clinical Science.2019;[Epub]     CrossRef
  • Almond-supplemented diet improves sexual functions beyond Phosphodiesterase-5 inhibition in diabetic male rats
    Adeniyi A. Adebayo, Ganiyu Oboh, Ayokunle O. Ademosun
    Heliyon.2019; 5(12): e03035.     CrossRef
  • Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy
    Mette Richner, Nelson Ferreira, Anete Dudele, Troels S. Jensen, Christian B. Vaegter, Nádia P. Gonçalves
    Frontiers in Neuroscience.2019;[Epub]     CrossRef
  • Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial
    Gerald Chen Jie Tan, Suzanne May Quinn Tan, Sonia Chew Wen Phang, Yeek Tat Ng, En Yng Ng, Badariah Ahmad, Uma Devi M. Palamisamy, Khalid Abdul Kadir
    Therapeutic Advances in Endocrinology and Metabolism.2019; 10: 204201881989546.     CrossRef
  • Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology
    Matthew Snelson, Melinda Coughlan
    Nutrients.2019; 11(2): 215.     CrossRef
  • Degradation of Peptide-Bound Maillard Reaction Products in Gastrointestinal Digests of Glyoxal-Glycated Casein by Human Colonic Microbiota
    Dan Xu, Lin Li, Xia Zhang, Hong Yao, Mingquan Yang, Zuoqi Gai, Bing Li, Di Zhao
    Journal of Agricultural and Food Chemistry.2019; 67(43): 12094.     CrossRef
  • Targeting inflammation in diabetic nephropathy: a tale of hope
    Juan Antonio Moreno, Carmen Gomez-Guerrero, Sebastian Mas, Ana Belen Sanz, Oscar Lorenzo, Marta Ruiz-Ortega, Lucas Opazo, Sergio Mezzano, Jesus Egido
    Expert Opinion on Investigational Drugs.2018; 27(11): 917.     CrossRef
  • Red Meat Consumption (Heme Iron Intake) and Risk for Diabetes and Comorbidities?
    Ranjita Misra, Padmini Balagopal, Sudha Raj, Thakor G. Patel
    Current Diabetes Reports.2018;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer