Diabetes & Metabolism Journal

Original Articles

Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells: Hae-Jung Lee, Yoon-Jung Choi, So-Young Park, Jong-Yeon Kim, Kyu-Chang Won, Jong-Keun Son, Yong-Woon Kim; Diabetes Metab J. 2015;39(1):51-58. Published online February 16, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.1.51

5,095 View
75 Download
11 Web of Science
8 Crossref

Background

Hyperglycemia, a characteristic feature of diabetes, induces glucotoxicity in pancreatic β-cells, resulting in further impairment of insulin secretion and worsening glycemic control. Thus, preservation of insulin secretory capacity is essential for the management of type 2 diabetes. In this study, we evaluated the ability of an Orthosiphon stamineus (OS) extract to prevent glucotoxicity in insulin-producing cells.

Methods

We measured insulin mRNA expression and glucose-stimulated insulin secretion (GSIS) in OS-treated INS-1 cells after exposure to a high glucose (HG; 30 mM) concentration.

Results

The hexane extract of OS elevated mRNA expression of insulin as well as pancreatic and duodenal homeobox-1 of INS-1 cells in a dose-dependent manner. The hexane OS extract also increased the levels of phosphorylated phosphatidylinositol 3-kinase (PI3K) in a concentration-dependent manner. Additionally, Akt phosphorylation was elevated by treatment with 100 and 200 µmol of the hexane OS extract. Three days of HG exposure suppressed insulin mRNA expression and GSIS; these expressions were restored by treatment with the hexane OS extract. HG elevated peroxide levels in the INS-1 cells. These levels were unaffected by OS treatment under both normal and hyperglycemic conditions.

Conclusion

Our results suggested that the hexane extract of OS elevates insulin mRNA expression and prevents glucotoxicity induced by a 3-day treatment with HG. This was associated with the activation of PI-3K and Akt.

Citations

Citations to this article as recorded by

An Updated Review of Ethnobotany, Ethnopharmacology, Phytochemistry and Pharmacological Activities of Orthosiphon stamineus Benth
Anandarajagopal Kalusalingam, Dania Najiha Hasnu, Abdullah Khan, Ching Siang Tan, Bama Menon, Venkateshan Narayanan, Khang Wen Goh, Asmuni Mohd Ikmal, Noraini Talip, Poonguzhali Subramanian, Long Chiau Ming
Malaysian Applied Biology.2024; 53(1): 1. CrossRef
Scopoletin protects INS-1 pancreatic β cells from glucotoxicity by reducing oxidative stress and apoptosis
Jae Eun Park, Ji Sook Han
Toxicology in Vitro.2023; 93: 105665. CrossRef
A Systematic Review of Orthosiphon stamineus Benth. in the Treatment of Diabetes and Its Complications
Qirou Wang, Jia Wang, Nannan Li, Junyu Liu, Jingna Zhou, Pengwei Zhuang, Haixia Chen
Molecules.2022; 27(2): 444. CrossRef
Comprehensive chemical and metabolic profiling of anti‐hyperglycemic active fraction from Clerodendranthi Spicati Herba
Yun Luo, Yue Liu, Quan Wen, Yulin Feng, Ting Tan
Journal of Separation Science.2021; 44(9): 1805. CrossRef
Short-Term Protocols to Obtain Insulin-Producing Cells from Rat Adipose Tissue: Signaling Pathways and In Vivo Effect
Krista Minéia Wartchow, Letícia Rodrigues, Lucas Zingano Suardi, Barbara Carolina Federhen, Nicholas Guerini Selistre, Carlos-Alberto Gonçalves, Patrícia Sesterheim
International Journal of Molecular Sciences.2019; 20(10): 2458. CrossRef
Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants
Chintha Lankatillake, Tien Huynh, Daniel A. Dias
Plant Methods.2019;[Epub] CrossRef
50% Ethanol extract of Orthosiphon stamineus modulates genotoxicity and clastogenicity induced by mitomycin C
Dhamraa Waleed Al-dualimi, Aman Shah Abdul Majid, Sarah Furqan Faisal Al-Shimary, Amal Aziz Al-Saadi, Raghdaa Al Zarzour, Muhammad Asif, Chern Ein Oon, Amin Malik Shah Abdul Majid
Drug and Chemical Toxicology.2018; 41(1): 82. CrossRef
Can Tea Extracts Exert a Protective Effect Against Diabetes by Reducing Oxidative Stress and Decreasing Glucotoxicity in Pancreatic β-Cells?
Heeyoung Chae, Patrick Gilon
Diabetes & Metabolism Journal.2015; 39(1): 27. CrossRef

Protective Effect of Heme Oxygenase-1 on High Glucose-Induced Pancreatic β-Cell Injury: Eun-Mi Lee, Young-Eun Lee, Esder Lee, Gyeong Ryul Ryu, Seung-Hyun Ko, Sung-Dae Moon, Ki-Ho Song, Yu-Bae Ahn; Diabetes Metab J. 2011;35(5):469-479. Published online October 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.5.469

4,559 View
42 Download
19 Crossref

Abstract PDF PubReader

Background

Glucose toxicity that is caused by chronic exposure to a high glucose concentration leads to islet dysfunction and induces apoptosis in pancreatic β-cells. Heme oxygenase-1 (HO-1) has been identified as an anti-apoptotic and cytoprotective gene. The purpose of this study is to investigate whether HO-1 up-regulation when using metalloprotophyrin (cobalt protoporphyrin, CoPP) could protect pancreatic β-cells from high glucose-induced apoptosis.

Methods

Reverse transcription-polymerase chain reaction was performed to analyze the CoPP-induced mRNA expression of HO-1. Cell viability of INS-1 cells cultured in the presence of CoPP was examined by acridine orange/propidium iodide staining. The generation of intracellular reactive oxygen species (ROS) was measured using flow cytometry. Glucose stimulated insulin secretion (GSIS) was determined following incubation with CoPP in different glucose concentrations.

Results

CoPP increased HO-1 mRNA expression in both a dose- and time-dependent manner. Overexpression of HO-1 inhibited caspase-3, and the number of dead cells in the presence of CoPP was significantly decreased when exposed to high glucose conditions (HG). CoPP also decreased the generation of intracellular ROS by 50% during 72 hours of culture with HG. However, decreased GSIS was not recovered even in the presence of CoPP.

Conclusion

Our data suggest that CoPP-induced HO-1 up-regulation results in protection from high glucose-induced apoptosis in INS-1 cells; however, glucose stimulated insulin secretion is not restored.

Citations

Citations to this article as recorded by

Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
Jeffrey Cummings, Andrew Ortiz, Janelle Castellino, Jefferson Kinney
European Journal of Neuroscience.2022; 56(9): 5727. CrossRef
The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. V. Johnson
Scientific Reports.2022;[Epub] CrossRef
CYTOCHROMES OF MITOCHONDRIES AND ACTIVITY OF HEME METABOLISM ENZYMES IN THE LIVER UNDER DIFFERENT NUTRIENT REGIMES
G.P. Kopylchuk, Z.-M. I. Grynenkiv, O.M. Voloshchuk
Fiziolohichnyĭ zhurnal.2021; 67(2): 37. CrossRef
Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
Mawieh Hamad, Abdul Khader Mohammed, Mahmood Y. Hachim, Debasmita Mukhopadhy, Anila Khalique, Amina Laham, Sarah Dhaiban, Khuloud Bajbouj, Jalal Taneera
Molecular and Cellular Endocrinology.2021; 538: 111462. CrossRef
Food-derived cyanidin-3-O-glucoside alleviates oxidative stress: evidence from the islet cell line and diabetic db/db mice
Xiang Ye, Wen Chen, Pengcheng Tu, Ruoyi Jia, Yangyang Liu, Yonglu Li, Qiong Tang, Xiaodong Zheng, Qiang Chu
Food & Function.2021; 12(22): 11599. CrossRef
Telmisartan protects against high glucose/high lipid‐induced apoptosis and insulin secretion by reducing the oxidative and ER stress
Yan Wang, Jingjing Xue, Yan Li, Xin Zhou, Shun Qiao, Dewu Han
Cell Biochemistry and Function.2019; 37(3): 161. CrossRef
Ropivacaine regulates the expression and function of heme oxygenase-1
Xiangbiao Yan, Yu Li, Xuechang Han, Xu Dong, Yajie Zhang, Qunzhi Xing
Biomedicine & Pharmacotherapy.2018; 103: 284. CrossRef
A review on heme oxygenase-1 induction: is it a necessary evil
Ajaz Ahmad Waza, Zeenat Hamid, Sajad Ali, Shabir Ahmad Bhat, Musadiq Ahmad Bhat
Inflammation Research.2018; 67(7): 579. CrossRef
Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects
Hee Jae Lee, Hye In Seo, Hee Yun Cha, Yun Jung Yang, Soo Hyun Kwon, Soo Jin Yang
Clinical Nutrition Research.2018; 7(4): 229. CrossRef
Social, economic, and policy implications of organ preservation advances
Alyssa Ward, David K. Klassen, Kate M. Franz, Sebastian Giwa, Jedediah K. Lewis
Current Opinion in Organ Transplantation.2018; 23(3): 336. CrossRef
Geniposide protects pancreatic β cells from high glucose‐mediated injury by activation of AMP‐activated protein kinase
Chunyan Liu, Yanan Hao, Fei Yin, Yonglan Zhang, Jianhui Liu
Cell Biology International.2017; 41(5): 544. CrossRef
Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats
N. M. Aziz, M. Y. Kamel, R. A. Rifaai
Endocrine Regulations.2017; 51(1): 20. CrossRef
Downregulation of microRNA-155 ameliorates high glucose-induced endothelial injury by inhibiting NF-κB activation and promoting HO-1 and NO production
Xi Zhang, Xiangyang Liu, Yang Li, Jingbo Lai, Nana Zhang, Jie Ming, Xianjie Ma, Qiuhe Ji, Ying Xing
Biomedicine & Pharmacotherapy.2017; 88: 1227. CrossRef
Sulforaphane Protects against High Cholesterol‐Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreatic β‐Cells Function
Catalina Carrasco-Pozo, Kah Ni Tan, Martin Gotteland, Karin Borges, Giuseppe Cirillo
Oxidative Medicine and Cellular Longevity.2017;[Epub] CrossRef
Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines
Kyril Turpaev, Nils Welsh
European Journal of Pharmacology.2016; 784: 69. CrossRef
Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion
Han-Hung Huang, Lisa Stehno-Bittel
Islets.2015; 7(5): e1129097. CrossRef
A newly identified polysaccharide from Ganoderma atrum attenuates hyperglycemia and hyperlipidemia
Kexue Zhu, Shaoping Nie, Chuan Li, Suli Lin, Mengmeng Xing, Wenjuan Li, Deming Gong, Mingyong Xie
International Journal of Biological Macromolecules.2013; 57: 142. CrossRef
Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction
Young Mi Song, Sun Ok Song, Young-Hye You, Kun-Ho Yoon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Ji-Won Kim, Byung-Wan Lee
Endocrinology.2013; 154(8): 2626. CrossRef
Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice
Young-Eun Lee, Ji-Won Kim, Eun-Mi Lee, Yu-Bae Ahn, Ki-Ho Song, Kun-Ho Yoon, Hyung-Wook Kim, Cheol-Whee Park, Guolian Li, Zhenqi Liu, Seung-Hyun Ko, Kathrin Maedler
PLoS ONE.2012; 7(11): e50412. CrossRef

Review

Glucolipotoxicity in Pancreatic β-Cells: Ji-Won Kim, Kun-Ho Yoon; Diabetes Metab J. 2011;35(5):444-450. Published online October 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.5.444

55,812 View
129 Download
59 Crossref

Abstract PDF PubReader

The recent epidemic of type 2 diabetes in Asia differs from that reported in other regions of the world in several key areas: it has evolved over a much shorter time, in an earlier stage of life, and in people with lower body mass indices. These phenotypic characteristics of patients strongly suggest that insulin secretory defects may perform a more important function in the development and progression of diabetes. A genetic element clearly underlies β-cell dysfunction and insufficient β-cell mass; however, a number of modifiable factors are also linked to β-cell deterioration, most notably chronic hyperglycemia and elevated free fatty acid (FFA) levels. Neither glucose nor FFAs alone cause clinically meaningful β-cell toxicity, especially in patients with normal or impaired glucose tolerance. Thus the term "glucolipotoxicity" is perhaps more appropriate in describing the phenomenon. Several mechanisms have been proposed to explain glucolipotoxicity-induced β-cell dysfunction and death, but its major factors appear to be depression of key transcription factor gene expression by altered intracellular energy metabolism and oxidative stress. Therefore, stabilization of metabolic changes induced by glucolipotoxicity in β-cells represents a new avenue for the treatment of type 2 diabetes mellitus.

Citations

Citations to this article as recorded by

Intravoxel incoherent motion diffusion-weighted imaging of pancreas: Probing evidence of β-cell dysfunction in asymptomatic adults with hyperglycemia in vivo
Yingying Song, Bo Chen, Kejing Zeng, Kejia Cai, Hui Sun, Deqing Liu, Ping Liu, Gugen Xu, Guihua Jiang
Magnetic Resonance Imaging.2024; 108: 161. CrossRef
PIMT Controls Insulin Synthesis and Secretion through PDX1
Rahul Sharma, Sujay K. Maity, Partha Chakrabarti, Madhumohan R. Katika, Satyamoorthy Kapettu, Kishore V. L. Parsa, Parimal Misra
International Journal of Molecular Sciences.2023; 24(9): 8084. CrossRef
Growth differentiation factor-15 prevents glucotoxicity and connexin-36 downregulation in pancreatic beta-cells
Mohamed Asrih, Rodolphe Dusaulcy, Yvan Gosmain, Jacques Philippe, Emmanuel Somm, François R. Jornayvaz, Baeki E. Kang, Yunju Jo, Min Jeong Choi, Hyon-Seung Yi, Dongryeol Ryu, Karim Gariani
Molecular and Cellular Endocrinology.2022; 541: 111503. CrossRef
Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives
Jasvinder Singh Bhatti, Abhishek Sehrawat, Jayapriya Mishra, Inderpal Singh Sidhu, Umashanker Navik, Naina Khullar, Shashank Kumar, Gurjit Kaur Bhatti, P. Hemachandra Reddy
Free Radical Biology and Medicine.2022; 184: 114. CrossRef
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity
Jonnell C. Small, Aidan Joblin-Mills, Kaycee Carbone, Maria Kost-Alimova, Kumiko Ayukawa, Carol Khodier, Vlado Dancik, Paul A. Clemons, Andrew B. Munkacsi, Bridget K. Wagner
ACS Chemical Biology.2022; 17(5): 1131. CrossRef
Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management
Svetlana Dinić, Jelena Arambašić Jovanović, Aleksandra Uskoković, Mirjana Mihailović, Nevena Grdović, Anja Tolić, Jovana Rajić, Marija Đorđević, Melita Vidaković
Frontiers in Endocrinology.2022;[Epub] CrossRef
Targeting pancreatic β cells for diabetes treatment
Chirag Jain, Ansarullah, Sara Bilekova, Heiko Lickert
Nature Metabolism.2022; 4(9): 1097. CrossRef
The high-fructose intake of dams during pregnancy and lactation exerts sex-specific effects on adult rat offspring metabolism
Francisca A. Tobar-Bernal, Sergio R. Zamudio, Lucía Quevedo-Corona
Journal of Developmental Origins of Health and Disease.2021; 12(3): 411. CrossRef
Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies
Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
International Journal of Molecular Sciences.2021; 22(10): 5303. CrossRef
A Review of Current Trends with Type 2 Diabetes Epidemiology, Aetiology, Pathogenesis, Treatments and Future Perspectives
Josh Reed, Stephen Bain, Venkateswarlu Kanamarlapudi
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 3567. CrossRef
Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2 Diabetes?
Ana Elena Rodriguez-Rodriguez, Esteban Porrini, Armando Torres
International Journal of Molecular Sciences.2021; 22(19): 10311. CrossRef
Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis
Piotr Wójcik, Neven Žarković, Agnieszka Gęgotek, Elżbieta Skrzydlewska
Biomolecules.2020; 10(3): 402. CrossRef
Phytochemicals as modulators of β-cells and immunity for the therapy of type 1 diabetes: Recent discoveries in pharmacological mechanisms and clinical potential
Maria Karmella Apaya, Tien-Fen Kuo, Meng-Ting Yang, Greta Yang, Chiao-Ling Hsiao, Song-Bin Chang, Yenshou Lin, Wen-Chin Yang
Pharmacological Research.2020; 156: 104754. CrossRef
Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases
Waihong Chung, Kittichai Promrat, Jack Wands
World Journal of Hepatology.2020; 12(9): 533. CrossRef
Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos
Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, Willi
Cell Reports.2019; 28(3): 759. CrossRef
Metabolic signatures suggest o-phosphocholine to UDP-N-acetylglucosamine ratio as a potential biomarker for high-glucose and/or palmitate exposure in pancreatic β-cells
Saleem Yousf, Devika M. Sardesai, Abraham B. Mathew, Rashi Khandelwal, Jhankar D. Acharya, Shilpy Sharma, Jeetender Chugh
Metabolomics.2019;[Epub] CrossRef
Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets
Elin Hall, Josefine Jönsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
Diabetes.2019; 68(10): 1965. CrossRef
Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation
Hyun-Je Kim, Ji Hwan Moon, Hyunwoo Chung, Jun-Seop Shin, Bongi Kim, Jong-Min Kim, Jung-Sik Kim, Il-Hee Yoon, Byoung-Hoon Min, Seong-Jun Kang, Yong-Hee Kim, Kyuri Jo, Joungmin Choi, Heejoon Chae, Won-Woo Lee, Sun Kim, Chung-Gyu Park
Scientific Reports.2019;[Epub] CrossRef
Centaurium erythraea extract improves survival and functionality of pancreatic beta-cells in diabetes through multiple routes of action
Miloš Đorđević, Nevena Grdović, Mirjana Mihailović, Jelena Arambašić Jovanović, Aleksandra Uskoković, Jovana Rajić, Marija Sinadinović, Anja Tolić, Danijela Mišić, Branislav Šiler, Goran Poznanović, Melita Vidaković, Svetlana Dinić
Journal of Ethnopharmacology.2019; 242: 112043. CrossRef
Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis
Wen Zeng, Jiansong Tang, Haicheng Li, Haixia Xu, Hongyun Lu, Hangya Peng, Chuwen Lin, Rili Gao, Shuo Lin, Keyi Lin, Kunying Liu, Yan Jiang, Jianping Weng, Longyi Zeng
Cellular Signalling.2018; 47: 65. CrossRef
Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity
Zonghong Li, Hongyang Liu, Zhangjing Niu, Wen Zhong, Miaomiao Xue, Jifeng Wang, Fuquan Yang, Yue Zhou, Yifa Zhou, Tao Xu, Junjie Hou
Molecular & Cellular Proteomics.2018; 17(11): 2119. CrossRef
Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass
Blandine Laferrère, François Pattou
Frontiers in Endocrinology.2018;[Epub] CrossRef
Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia
Aparecida Gabriela Bexiga Veloso, Nathalia Edviges Alves Lima, Elisabete de Marco Ornelas, Clever Gomes Cardoso, Mara Rubia Marques, Beatriz da Costa Aguiar Alves Reis, Fernando Luiz Affonso Fonseca, Laura Beatriz Mesiano Maifrino
Medical Molecular Morphology.2018; 51(2): 118. CrossRef
Cardiac Glucolipotoxicity and Cardiovascular Outcomes
Marlon E. Cerf
Medicina.2018; 54(5): 70. CrossRef
High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant
Jianhui Liu, Kunimasa Yagi, Atsushi Nohara, Daisuke Chujo, Azusa Ohbatake, Aya Fujimoto, Yukiko Miyamoto, Junji Kobayashi, Masakazu Yamagishi
Journal of Clinical Lipidology.2018; 12(2): 331. CrossRef
Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven
Dulce Morales, Guillermo Ramirez, Armando Herrera-Arellano, Jaime Tortoriello, Miguel Zavala, Alejandro Zamilpa, Mohammed S. Razzaque
Evidence-Based Complementary and Alternative Medicine.2018;[Epub] CrossRef
The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response
Jingqi Fu, Qi Cui, Bei Yang, Yongyong Hou, Huihui Wang, Yuanyuan Xu, Difei Wang, Qiang Zhang, Jingbo Pi
Food and Chemical Toxicology.2017; 100: 161. CrossRef
Phenolic constituents and modulatory effects of Raffia palm leaf ( Raphia hookeri ) extract on carbohydrate hydrolyzing enzymes linked to type-2 diabetes
Felix A. Dada, Sunday I. Oyeleye, Opeyemi B. Ogunsuyi, Tosin A. Olasehinde, Stephen A. Adefegha, Ganiyu Oboh, Aline A. Boligon
Journal of Traditional and Complementary Medicine.2017; 7(4): 494. CrossRef
A gene-environment interaction analysis of plasma selenium with prevalent and incident diabetes: The Hortega study
Inmaculada Galan-Chilet, Maria Grau-Perez, Griselda De Marco, Eliseo Guallar, Juan Carlos Martin-Escudero, Alejandro Dominguez-Lucas, Isabel Gonzalez-Manzano, Raul Lopez-Izquierdo, Laisa Socorro Briongos-Figuero, Josep Redon, Felipe Javier Chaves, Maria T
Redox Biology.2017; 12: 798. CrossRef
Differential dose-dependent Effects of Zinc Oxide Nanoparticles on Oxidative stress-mediated Pancreatic β-cell Death
Swati C Asani, Rinku D Umrani, Kishore M Paknikar
Nanomedicine.2017; 12(7): 745. CrossRef
Mild hyperglycemia triggered islet function recovery in streptozotocin‐induced insulin‐deficient diabetic rats
Yu Cheng, Jing Shen, Weizheng Ren, Haojie Hao, Zongyan Xie, Jiejie Liu, Yiming Mu, Weidong Han
Journal of Diabetes Investigation.2017; 8(1): 44. CrossRef
The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells
Atsuko Kitahara, Kazuto Takahashi, Naru Morita, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Toshiaki Tanaka, Takuma Kondo, Toshio Hosaka, Hitoshi Ishida
Marine Drugs.2017; 15(6): 185. CrossRef
Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice
Esther Nuñez-Durán, Belén Chanclón, Silva Sütt, Joana Real, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Emmelie Cansby, Margit Mahlapuu
Journal of Endocrinology.2017; 234(1): 15. CrossRef
Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
Journal of Diabetes and its Complications.2017; 31(1): 21. CrossRef
The Glucotoxicity Protecting Effect of Ezetimibe in Pancreatic Beta Cells via Inhibition of CD36
Ji Sung Yoon, Jun Sung Moon, Yong-Woon Kim, Kyu Chang Won, Hyoung Woo Lee
Journal of Korean Medical Science.2016; 31(4): 547. CrossRef
The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients
Chenxiao Liu, Xianjin Ke, Ying Wang, Xiu Feng, Qi Li, Ying Zhang, Jian Zhu, Qian Li
BMC Endocrine Disorders.2016;[Epub] CrossRef
Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
Midhat H. Abdulreda, Rayner Rodriguez-Diaz, Alejandro Caicedo, Per-Olof Berggren
Cell Metabolism.2016; 23(3): 541. CrossRef
Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes
Purvi C. Trivedi, Jordan J. Bartlett, Lester J. Perez, Keith R. Brunt, Jean Francois Legare, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2016; 1861(12): 1893. CrossRef
Diabetes risk prediction model for non‐obese Asian Indians residing in North India using cut‐off values for pancreatic and intra‐abdominal fat volume and liver span
Shajith Anoop, Anoop Misra, Kalaivani Mani, Ravindra Mohan Pandey, Seema Gulati
Journal of Diabetes.2016; 8(5): 729. CrossRef
Identifying crop variants with high resistant starch content to maintain healthy glucose homeostasis
K. Petropoulou, E. S. Chambers, D. J. Morrison, T. Preston, I. F. Godsland, P. Wilde, A. Narbad, R. Parker, L. Salt, V. J. Morris, C. Domoney, S. J. Persaud, E. Holmes, S. Penson, J. Watson, M. Stocks, M. Buurman, M. Luterbacher, G. Frost
Nutrition Bulletin.2016; 41(4): 372. CrossRef
Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets
CHENGHU HUANG, LI YUAN, SHUYI CAO
International Journal of Molecular Medicine.2015; 36(1): 173. CrossRef
Mitochondrien als Kraftwerk der β-Zelle
S. Baltrusch, F. Reinhardt, M. Tiedge
Der Diabetologe.2015; 11(3): 231. CrossRef
Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells
LiLi Gao, Wei Tang, ZhengZheng Ding, DingYu Wang, XiaoQiang Qi, HuiWen Wu, Jun Guo
Molecular Medicine.2015; 21(1): 154. CrossRef
Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells
Sergio Wehinger, Rina Ortiz, María Inés Díaz, Adam Aguirre, Manuel Valenzuela, Paola Llanos, Christopher Mc Master, Lisette Leyton, Andrew F.G. Quest
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(5): 693. CrossRef
Body Fat Patterning, Hepatic Fat and Pancreatic Volume of Non-Obese Asian Indians with Type 2 Diabetes in North India: A Case-Control Study
Anoop Misra, Shajith Anoop, Seema Gulati, Kalaivani Mani, Surya Prakash Bhatt, Ravindra Mohan Pandey, Anna Alisi
PLOS ONE.2015; 10(10): e0140447. CrossRef
CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells
Udayakumar Karunakaran, Jun Sung Moon, Hyoung Woo Lee, Kyu Chang Won
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2015; 1852(11): 2414. CrossRef
Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1
Mark F McCarty, James J DiNicolantonio
Open Heart.2015; 2(1): e000205. CrossRef
Acarbose: safe and effective for lowering postprandial hyperglycaemia and improving cardiovascular outcomes
James J DiNicolantonio, Jaikrit Bhutani, James H O'Keefe
Open Heart.2015; 2(1): e000327. CrossRef
P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells
Lingli Zhou, Xiaoling Cai, Xueyao Han, Linong Ji
Journal of Diabetes Research.2014; 2014: 1. CrossRef
ImpairedβCell Function in Chinese Newly Diagnosed Type 2 Diabetes Mellitus with Hyperlipidemia
Yuhang Ma, Yufan Wang, Qianfang Huang, Qian Ren, Su Chen, Aifang Zhang, Li Zhao, Qin Zhen, Yongde Peng
Journal of Diabetes Research.2014; 2014: 1. CrossRef
Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation
Ana L. Guadarrama-López, Roxana Valdés-Ramos, Beatríz E. Martínez-Carrillo
Journal of Immunology Research.2014; 2014: 1. CrossRef
A Comparative Study of the Effects of a Dipeptidyl Peptidase-IV Inhibitor and Sulfonylurea on Glucose Variability in Patients with Type 2 Diabetes with Inadequate Glycemic Control on Metformin
Hun-Sung Kim, Jeong-Ah Shin, Seung-Hwan Lee, Eun-Sook Kim, Jae-Hyoung Cho, Ho-Young Son, Kun-Ho Yoon
Diabetes Technology & Therapeutics.2013; 15(10): 810. CrossRef
Localization and regulation of pancreatic selenoprotein P
Holger Steinbrenner, Anna-Lena Hotze, Bodo Speckmann, Antonio Pinto, Helmut Sies, Matthias Schott, Margret Ehlers, Werner A Scherbaum, Sven Schinner
Journal of Molecular Endocrinology.2013; 50(1): 31. CrossRef
Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction
Young Mi Song, Sun Ok Song, Young-Hye You, Kun-Ho Yoon, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Ji-Won Kim, Byung-Wan Lee
Endocrinology.2013; 154(8): 2626. CrossRef
miRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models
J.-W. Kim, Y.-H. You, S. Jung, H. Suh-Kim, I.-K. Lee, J.-H. Cho, K.-H. Yoon
Diabetologia.2013; 56(4): 847. CrossRef
Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population
E. M. Brady, D. R. Webb, D. H. Morris, K. Khunti, D. S. C. Talbot, N. Sattar, M. J. Davies
Experimental Diabetes Research.2012; 2012: 1. CrossRef
Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells
Yong-Woon Kim, Jun Sung Moon, Ye Jin Seo, So-Young Park, Jong-Yeon Kim, Ji Sung Yoon, In-Kyu Lee, Hyoung Woo Lee, Kyu Chang Won
Biochemical and Biophysical Research Communications.2012; 420(2): 462. CrossRef
Human Monoclonal Antibodies against Glucagon Receptor Improve Glucose Homeostasis by Suppression of Hepatic Glucose Output in Diet-Induced Obese Mice
Wook-Dong Kim, Yong-ho Lee, Min-Hee Kim, Sun-Young Jung, Woo-Chan Son, Seon-Joo Yoon, Byung-Wan Lee, Nigel Irwin
PLoS ONE.2012; 7(12): e50954. CrossRef
Understanding Pancreas Development for β-Cell Repair and Replacement Therapies
Aurelia Raducanu, Heiko Lickert
Current Diabetes Reports.2012; 12(5): 481. CrossRef

First
Prev
Page of 1
Next
Last

Search