Diabetes & Metabolism Journal

Sulwon Lecture 2025

Lifestyle and Behavioral Interventions
Exercise, Exerkines, and Sarcopenia: Hye Soo Chung, Kyung Mook Choi; Diabetes Metab J. 2026;50(1):19-29. Published online January 1, 2026; DOI: https://doi.org/10.4093/dmj.2025.0972

2,907 View
198 Download

Abstract PDF PubReader ePub: Sarcopenia is a progressive age-related musculoskeletal disorder characterized by loss of skeletal muscle mass, strength, and physical function. Closely associated with aging and physical inactivity, it significantly compromises mobility, independence, and quality of life in older adults. Exercise is widely recognized as an effective non-pharmacological intervention for managing sarcopenia. However, the underlying molecular mechanisms remain incompletely elucidated. Among the emerging mediators, exerkines, physical exercise-induced signaling molecules, are secreted by multiple tissues, including the skeletal muscle, bone, liver, and adipose tissue, and mediate the systemic beneficial impacts of exercise via autocrine, paracrine, and endocrine signaling. These factors play critical roles in interorgan communication, regulation of muscle regeneration, mitochondrial function, inflammation, and metabolic homeostasis. Importantly, the secretion profiles and biological functions of exerkines are modulated by exercise-specific parameters such as mode, intensity, and duration. Understanding the regulatory dynamics of exerkine signaling may offer novel therapeutic avenues, particularly for individuals unable to engage in regular physical activity. This review focuses on the recently identified exerkines relevant to skeletal muscle physiology and their implications in the pathophysiology of sarcopenia. We also provided a comprehensive overview of exerkine responses to various exercise modalities in the prevention and treatment of sarcopenia.

Review

Lifestyle and Behavioral Interventions
Optimizing Physical Activity Strategies for Older Adults with Diabetes: Hyeon-Jin Yu, Doyoun Hong, Kyuho Kim, Ji Hye Heo, Dong-Hyeok Cho, Yoshitaka Hashimoto, Jae-Seung Yun; Diabetes Metab J. 2025;49(6):1178-1197. Published online November 1, 2025; DOI: https://doi.org/10.4093/dmj.2025.0967

2,197 View
125 Download

Abstract PDF PubReader ePub: The increasing prevalence of diabetes among older adults has emerged as a major socioeconomic burden. This population is highly heterogeneous, ranging from functionally independent to severely impaired individuals, making it difficult to establish standardized recommendations. Physical activity (PA) is a cornerstone of diabetes management; however, current exercise guidelines do not adequately address the wide spectrum of functional capacities observed in older adults. For those with physical limitations, relatively simple activities such as walking, breaking up sedentary time, incorporating movement into daily routines, and aquatic exercise have been proposed, yet supporting evidence remains limited. This review summarizes the pathophysiologic mechanisms of metabolic and functional changes associated with aging and diabetes—including sarcopenia, altered body composition, and cardiovascular decline—and comprehensively discusses the benefits and precautions of various exercise modalities, tailored recommendations according to diabetes-related complications, and key clinical considerations. We further classified older adults with diabetes into three functional levels, individuals in good health, those with some comorbidities or mild disabilities, and those with high comorbidities and/or functional impairment, and proposed corresponding physical activity strategies for each level. Finally, we highlight practical and feasible approaches, including walking, interrupting sedentary behavior, daily functional movements, and aquatic exercise, to enhance clinical applicability for individuals with reduced physical capacity. These tailored, function-based strategies may help older adults with diabetes achieve safer, more effective, and sustainable improvements in glycemic control and overall health.

Original Articles

Cardiovascular Risk/Epidemiology
Associations of Cardiocerebrovascular Risks and Exercise according to Menopausal Status in Women with Type 2 Diabetes Mellitus: A Nationwide Cohort Study: Ji-Hee Ko, Sun Joon Moon, Kyung-Do Han, Hye-Mi Kwon, Se-Eun Park, Eun-Jung Rhee, Won-Young Lee; Diabetes Metab J. 2026;50(1):101-114. Published online August 13, 2025; DOI: https://doi.org/10.4093/dmj.2024.0487

1,723 View
60 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Menopausal status can increase the risk of cardiocerebrovascular diseases (CCVDs) in women with type 2 diabetes mellitus (T2DM). Regular exercise is well-known to reduce this risk. This study explored the impact of exercise on CCVD and mortality in women with T2DM according to their menopausal status.
Methods
A total of 32,477 premenopausal and 53,690 postmenopausal Korean women with T2DM aged 40 to 60 years from a national health examination cohort (2009 to 2018) were included. We evaluated risks for stroke, myocardial infarction (MI), and mortality based on exercise intensity. Cox proportional hazard regression analyses were performed to obtain the adjusted hazard ratio (aHR) and 95% confidence interval.
Results
Exercise reduced stroke, MI, and mortality risks in women with T2DM, regardless of menopausal status. The highest effects of aHR compared to the sedentary group were 0.68 for stroke, 0.66 for MI, and 0.81 for mortality. Postmenopausal women experienced significant MI risk reductions at most exercise intensities, with the greatest reduction in the ≥1,500 metabolic equivalent of task score group unlike premenopausal women. However, stroke and mortality risk reductions in postmenopausal women were less pronounced compared to premenopausal women.
Conclusion
Exercise reduces CCVD risk in women with T2DM across menopausal status. Postmenopausal women with T2DM had more benefits from exercise on MI but fewer benefits on stroke and mortality than premenopausal women. In premenopausal women with T2DM, exercise was not associated with a lower MI risk.

Lifestyle and Behavioral Interventions
The Preventive Effect of Physical Activity on Gestational Diabetes Mellitus: A Korean Longitudinal Prospective Cohort Study: Ji Hyae Lim, Min Hyoung Kim, Hye-Ji Han, Su Ji Yang, Myung-Gwan Kim, Hyun Jung Lee, You Jung Han, Jin Hoon Chung, Dong Wook Kwak, Seongwoo Yang, Moon Young Kim, Hyun Mee Ryu; Diabetes Metab J. 2025;49(5):1116-1125. Published online April 23, 2025; DOI: https://doi.org/10.4093/dmj.2024.0280

3,461 View
212 Download
2 Web of Science
2 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
To assess longitudinally physical activity patterns and intensity from pre-pregnancy to postpartum and evaluate the association between timing and type of physical activity and the development of gestational diabetes mellitus (GDM).
Methods
The Korean Pregnancy Outcome Study (KPOS) is a prospective cohort study conducted from 2013 to 2017. Our study included 3,457 participants with singleton pregnancies in KPOS, classified according to the pregnancy outcome: GDM (n=231) and normal (n=3,226). Physical activity data were collected at five time points using the short form of the International Physical Activity Questionnaire: before pregnancy, at 12, 24, and 36 gestational weeks (GW), and 6–8 weeks postpartum. Pre-pregnancy physical activity was collected through recall at 12 GW.
Results
Maternal age, pre-pregnancy body mass index, educational status, smoking, mini dietary assessment index, first-degree family history of diabetes, hypertension, parity, pre-existing GDM, and previous macrosomia showed significant differences between the GDM group and the normal group (P<0.05 for all). Pre-pregnancy muscle-strengthening activity was significantly associated with a lower risk of GDM (adjusted odds ratio, 0.46; 95% confidence interval, 0.25 to 0.85).
Conclusion
These findings suggest that physical activity, such as muscle-strengthening activities before pregnancy, could be a preventive strategy to reduce GDM risk. Although the study does not provide evidence that physical activity during pregnancy and postpartum reduces GDM risk, it offers significant insights into the importance of maintaining a healthy level of physical activity from pre-pregnancy to prevent GDM.

Citations

Citations to this article as recorded by

Pre-Conception Physical Activity and the Risk of Gestational Diabetes Mellitus: Findings from the BORN 2020 Study
Antigoni Tranidou, Antonios Siargkas, Ioannis Tsakiridis, Emmanuela Magriplis, Aikaterini Apostolopoulou, Georgia Koutsouki, Michail Chourdakis, Themistoklis Dagklis
Nutrients.2025; 17(11): 1832. CrossRef
Prediction of Gestational Diabetes Mellitus: A Nomogram Model Incorporating Lifestyle, Nutrition and Health Literacy Factors
Minghan Fu, Menglu Qiu, Zhencheng Xie, Laidi Guo, Yun Zhou, Jia Yin, Wanyi Yang, Lishan Ouyang, Ye Ding, Zhixu Wang
Nutrients.2025; 17(21): 3400. CrossRef

Basic and Translational Research
Effect of 4 Weeks Resonance Frequency Breathing on Glucose Metabolism and Autonomic Tone in Healthy Adults: Benedict Herhaus, Andreas Peter, Julia Hummel, Thomas Kubiak, Martin Heni, Katja Petrowski; Diabetes Metab J. 2025;49(6):1219-1228. Published online April 3, 2025; DOI: https://doi.org/10.4093/dmj.2024.0647

3,605 View
118 Download
1 Web of Science
1 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
The autonomic nervous system plays a crucial role in the brain’s communication with metabolically important peripheral organs, modulating insulin sensitivity and secretion. Increased sympathetic tone is a common feature in prediabetes and diabetes. The parasympathetic nervous system activity might be improvable through resonance frequency breathing (RFB) with heart rate variability biofeedback (HRV-BF) training.
Methods
We here investigated the effect of a 4-week mobile RFB-HRV-BF intervention on glucose metabolism and HRV of 30 healthy adults (17 females; mean age 25.77±3.64 years; mean body mass index 22.65±2.95 kg/m²). Before and after the intervention, glucose metabolism was assessed by 75 g oral glucose tolerance tests (with blood sampling every 30 minutes over 2 hours) and HRV was measured through electrocardiography.
Results
RFB-HRV-BF training did not influence glucose metabolism in healthy adults but reduced fasting as well as 2-hour-postload glucose in participants categorized as more insulin resistant before the intervention. In addition, RFB-HRV-BF training was associated with an increase in the time and frequency domain HRV parameters standard deviation of all NN-intervals, root mean square successive differences, HRV high-frequency and HRV low-frequency after 4 weeks of intervention.
Conclusion
Our findings introduce RFB-HRV-BF training as an effective tool to modulate the autonomic nervous system with a shift towards the parasympathetic tone. Along with the observed decrease in glycemia in those with lower insulin sensitivity, RFB-HRV-BF training emerges as a promising non-pharmacological approach to improve glucose metabolism which has to be further investigated in prediabetes and diabetes.

Citations

Citations to this article as recorded by

The autonomic nervous system in the regulation of glucose and lipid metabolism
Sabrina Wangler, Marc N. Jarczok, Matthew Ennis, Benedict Herhaus, Róbert Wagner, Ratika Sehgal, Martin Heni
Nature Reviews Endocrinology.2026;[Epub] CrossRef

Reviews

Cardiovascular Risk/Epidemiology
Artificial Light at Night and Type 2 Diabetes Mellitus: Jong-Ha Baek, Yong Zhu, Chandra L. Jackson, Yong-Moon Mark Park; Diabetes Metab J. 2024;48(5):847-863. Published online September 1, 2024; DOI: https://doi.org/10.4093/dmj.2024.0237

25,595 View
527 Download
11 Web of Science
11 Crossref

Abstract PDF PubReader ePub

The widespread and pervasive use of artificial light at night (ALAN) in our modern 24-hour society has emerged as a substantial disruptor of natural circadian rhythms, potentially leading to a rise in unhealthy lifestyle-related behaviors (e.g., poor sleep; shift work). This phenomenon has been associated with an increased risk of type 2 diabetes mellitus (T2DM), which is a pressing global public health concern. However, to date, reviews summarizing associations between ALAN and T2DM have primarily focused on the limited characteristics of exposure (e.g., intensity) to ALAN. This literature review extends beyond prior reviews by consolidating recent studies from 2000 to 2024 regarding associations between both indoor and outdoor ALAN exposure and the incidence or prevalence of T2DM. We also described potential biological mechanisms through which ALAN modulates glucose metabolism. Furthermore, we outlined knowledge gaps and investigated how various ALAN characteristics beyond only light intensity (including light type, timing, duration, wavelength, and individual sensitivity) influence T2DM risk. Recognizing the detrimental impact of ALAN on sleep health and the behavioral correlates of physical activity and dietary patterns, we additionally summarized studies investigating the potential mediating role of each component in the relationship between ALAN and glucose metabolism. Lastly, we proposed implications of chronotherapies and chrononutrition for diabetes management in the context of ALAN exposure.

Citations

Citations to this article as recorded by

Impact of bedroom light exposure on glucose metabolic markers and the role of circadian-dependent meal timing: A population-based cross-sectional study
Qi Li, Yu-xiang Xu, Xiu-zhen Lu, Yu-ting Shen, Yu-hui Wan, Pu-yu Su, Fang-biao Tao, Xin Chen, Ying Sun
Ecotoxicology and Environmental Safety.2025; 290: 117589. CrossRef
The impact of environmental pollution on metabolic health and the risk of non-communicable chronic metabolic diseases in humans
Caterina Formichi, Sonia Caprio, Laura Nigi, Francesco Dotta
Nutrition, Metabolism and Cardiovascular Diseases.2025; 35(6): 103975. CrossRef
Synergistic effects of air pollution and artificial light at night on diabetes risk: A prospective cohort study
Desong Wen, Fei Lin, Chaowei Zhang, Ziyu Ge, Xiaohang Li, Zhenzhou Liu, Hanqing Zhao, Weimin Wang, Zhigang Chen, Guoan Zhao
Environmental Pollution.2025; 379: 126472. CrossRef
Artificial light exposure at night: A hidden risk factor for type 2 diabetes
Izere Salomon, Shema Sam, Yahya Ur Rehman, Intwari Munyaneza Hope
Sleep Medicine: X.2025; 10: 100146. CrossRef
Timing and Amplitude of Light Exposure, Not Photoperiod, Predict Blood Lipids in Arctic Residents: A Circadian Light Hypothesis
Denis Gubin, Sergey Kolomeichuk, Konstantin Danilenko, Oliver Stefani, Alexander Markov, Ivan Petrov, Kirill Voronin, Marina Mezhakova, Mikhail Borisenkov, Aislu Shigabaeva, Julia Boldyreva, Julianna Petrova, Larisa Alkhimova, Dietmar Weinert, Germaine Co
Biology.2025; 14(7): 799. CrossRef
Association between outdoor artificial light at night, circadian health, and LDL-C in intracranial artery atherosclerotic stenosis
Le Yang, Quan Wang, He Zheng, Yiqing Wang, Zhigang Miao, Hao Li, Yi Yang
Clinical Epigenetics.2025;[Epub] CrossRef
Independent and combined relationships between light at night, air pollutants, PM2.5 components and risk of cardiovascular-kidney-metabolic syndrome: a cohort study
Ziyue Liang, Siyu Qing, Yifang Liang, Renfang Zhang, Mengyao Sun, Ziyu Ren, Chunejie Xu, Fei Lin, Yongbin Wang
BMC Public Health.2025;[Epub] CrossRef
Independent and combined relationships between nighttime light exposure, air pollution, PM2.5 constituents, greenness and diabetes or high blood sugar: a national prospective cohort study
Siyu Qing, Ziyue Liang, Yifang Liang, Renfang Zhang, Xiaojie Chen, Wenqing Wang, Chunejie Xu, Fei Lin, Yongbin Wang
BMC Public Health.2025;[Epub] CrossRef
Glucose homeostasis during recurrent periods of sleep restriction and recovery in healthy young adults
Yuki Y Y Cheung, Torance Y L Tan, Tiffany B Koa, Chin Meng Khoo, June C Lo
SLEEPJ.2025;[Epub] CrossRef
Normalized Amplitude of Blue Light Exposure (NA BLE) as a Novel Index for Circadian Light Hygiene: Associations with Actigraphy Measures and Seasonal Dependencies
Denis G. Gubin, Julia V. Boldyreva, Liina A. Danilova, Sergei N. Kolomeichuk, Larisa E. Alkhimova, Alexander A. Markov, Olga A. Malyugina, Natalya V. Kuznetsova, Oliver Stefani, Dietmar Weinert, Germaine Cornelissen
Russian Open Medical Journal.2025;[Epub] CrossRef
Circadian Deregulation: Back Facing the Sun Toward Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development
Mariana Verdelho Machado
Nutrients.2024; 16(24): 4294. CrossRef

Lifestyle
Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies: Jakub Mesinovic, Jackson J. Fyfe, Jason Talevski, Michael J. Wheeler, Gloria K.W. Leung, Elena S. George, Melkamu T. Hunegnaw, Costas Glavas, Paul Jansons, Robin M. Daly, David Scott; Diabetes Metab J. 2023;47(6):719-742. Published online September 14, 2023; DOI: https://doi.org/10.4093/dmj.2023.0112

29,181 View
967 Download
46 Web of Science
53 Crossref

Abstract PDF PubReader ePub

Type 2 diabetes mellitus (T2DM) and sarcopenia (low skeletal muscle mass and function) share a bidirectional relationship. The prevalence of these diseases increases with age and they share common risk factors. Skeletal muscle fat infiltration, commonly referred to as myosteatosis, may be a major contributor to both T2DM and sarcopenia in older adults via independent effects on insulin resistance and muscle health. Many strategies to manage T2DM result in energy restriction and subsequent weight loss, and this can lead to significant declines in muscle mass in the absence of resistance exercise, which is also a first-line treatment for sarcopenia. In this review, we highlight recent evidence on established treatments and emerging therapies targeting weight loss and muscle mass and function improvements in older adults with, or at risk of, T2DM and/or sarcopenia. This includes dietary, physical activity and exercise interventions, new generation incretin-based agonists and myostatin-based antagonists, and endoscopic bariatric therapies. We also highlight how digital health technologies and health literacy interventions can increase uptake of, and adherence to, established and emerging treatments and therapies in older adults with T2DM and/or sarcopenia.

Citations

Citations to this article as recorded by

Comparing bone and muscle parameters in community-dwelling older adults with obesity, with or without type 2 diabetes mellitus
Costas Glavas, Jakub Mesinovic, Peter R. Ebeling, Surbhi Sood, Elena S. George, Melkamu Tamir Hunegnaw, Ayse Zengin, Robin M. Daly, Paul Jansons, David Scott
Bone.2026; 202: 117680. CrossRef
Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta‐analysis
Yueh‐Chu Wu, Man‐Ting Mao, Hung‐En Huang, Chien‐Ning Huang, Wen‐Chun Liao
Journal of Diabetes Investigation.2026; 17(1): 83. CrossRef
Sarcopenia and MASLD: novel insights and the future
Chang-Hai Liu, Qing-Min Zeng, Won Kim, Seung Up Kim, Zobair M. Younossi, Giovanni Targher, Christopher D. Byrne, Christos S. Mantzoros, Phunchai Charatcharoenwitthaya, Isabelle Anne Leclercq, Manuel Romero-Gómez, Hong Tang, Ming-Hua Zheng
Nature Reviews Endocrinology.2026; 22(3): 139. CrossRef
Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study
Shuxu Wei, Zhouwu Shu, Xinyi Li, Suiqin Zhong, Ling Xiao, Ronghuai Shen, Xiaojia Lu, Lingbin He, Youti Zhang, Yan Quan, Xianxi Huang
Metabolism.2026; 175: 156452. CrossRef
Ageing of human myofibres in the Vastus Lateralis muscle: A narrative review
Antoneta Granic, Davina C.M. Simoes, T. Scott Bowen, Nessrin Almaghtuf, Gavin Richardson, Avan A. Sayer
Ageing Research Reviews.2026; 115: 103022. CrossRef
Assessment of screening tools for diabetic sarcopenia in type 2 diabetes mellitus: evidence from a scoping review
Jiawei Yin, Xiaotu Zhang, Jing Cai, Hongshi Zhang, Xuefeng Sun, Zilin Wang, Ye Zhang, Lin Li
Frontiers in Endocrinology.2026;[Epub] CrossRef
Body composition and bone mineral density in patients with type 2 diabetes mellitus and sarcopenia
Mo Li, Qing Zhao
International Journal of Diabetes in Developing Countries.2026;[Epub] CrossRef
How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review
Sophie Van Heden, Zoubayda Baoubbou, Dolores Sanchez‐Rodriguez, Yoke Mun Chan, Charlotte Beaudart
Journal of Cachexia, Sarcopenia and Muscle.2026;[Epub] CrossRef
Exercise, Exerkines, and Sarcopenia
Hye Soo Chung, Kyung Mook Choi
Diabetes & Metabolism Journal.2026; 50(1): 19. CrossRef
Development and validation of a machine learning-based sarcopenia prediction model using the triglyceride glucose–frailty index
Wang Xiang, Houcheng Zhu, Xiandong Liu, Qingsong Wu
Journal of International Medical Research.2026;[Epub] CrossRef
Association between weight-adjusted waist index and the incidence of low back pain among middle-aged and older adults: a nationwide prospective cohort study in China
Xiujie Meng, Wenlong Yu, Junming Ma
European Spine Journal.2026;[Epub] CrossRef
Investigation of the Relationship Between Glycemic Control and Inflammation–Nutrition Indices in Older Adults with Type 2 Diabetes
Feyza Mutlay, Murat Das, Merve Durmaz Yıldız, Ferhan Demirer Aydemir, Ece Ünal Çetin, Özge Kurtkulağı
Medicina.2026; 62(2): 369. CrossRef
Higher body mass index increases the risk of shoulder adhesive capsulitis in young adults: a nationwide cohort study
Jong-Ho Kim, Jae-Yoon Baek, Kyung-Do Han, Bong-Seoung Kim, Hyuk-Sang Kwon
Journal of Shoulder and Elbow Surgery.2025; 34(1): 26. CrossRef
Unraveling the dual threat: sarcopenia and insufficient physical activity in diabetes risk
Hui Shi
Frontiers in Endocrinology.2025;[Epub] CrossRef
Molecular insights into Parkinson's disease and type 2 diabetes mellitus: Metformin's role and genetic pathways explored
Tingting Liu, Haojie Wu, Jianshe Wei
Experimental Neurology.2025; 385: 115137. CrossRef
Relationship between Muscle Mass by Bioimpedance and Vascular Complications in Type 2 Diabetes Mellitus
Alejandra Calderón, Cristina Arteaga, Elizabeth Quiroga, Lisbeth Reales, Marcelo Pilamunga, Fernanda Marizande, Alberto Bustillos
Salud, Ciencia y Tecnología.2025;[Epub] CrossRef
Impact of socioeconomic status on utilisation of a Virtual Emergency Department: An exploratory analysis
Jason Talevski, Shady Rizk, Loren Sher, Rebecca L Jessup, Adam I Semciw, James H Boyd, Suzanne M Miller, Jennie Hutton
Emergency Medicine Australasia.2025;[Epub] CrossRef
Risk factors for sarcopenia in community setting across the life course: A systematic review and a meta-analysis of longitudinal studies
Yajing Gao, Yuli Huang, Ran An, Yi Yang, Xinyao Chen, Qiaoqin Wan
Archives of Gerontology and Geriatrics.2025; 133: 105807. CrossRef
Development and validation of a predictive model for the risk of possible sarcopenia in middle-aged and older adult diabetes mellitus in China
Mengyuan Qiao, Haiyan Wang, Mengzhen Qin, Taohong Xing, Yingyang Li
Frontiers in Public Health.2025;[Epub] CrossRef
Primary Hyperparathyroidism: An Analysis Amid the Co-Occurrence of Type 2 Diabetes Mellitus
Ana-Maria Gheorghe, Mihaela Stanciu, Claudiu Nistor, Ioana Codruta Lebada, Mara Carsote
Life.2025; 15(4): 677. CrossRef
A comparative analysis of sarcopenia screening methods in Thai people with type 2 diabetes mellitus in an outpatient setting
Ornpicha Laohajaroensombat, Thanapat Limpaarayakul, Nattapol Sathavarodom, Apussanee Boonyavarakul, Parinya Samakkarnthai
BMC Geriatrics.2025;[Epub] CrossRef
Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide
Jakub Mesinovic, Christopher Hurst, Gloria K. W. Leung, Jack R. Ryan, Robin M. Daly, David Scott
Reviews in Endocrine and Metabolic Disorders.2025; 26(5): 785. CrossRef
Exploring the link between age at menarche, anthropometry and body fat composition with type II diabetes in a Singapore multi-ethnic cohort
Paula Benny, Qian Yang, Beverly Wen-Xin Wong, Cuilin Zhang, Eu-Leong Yong, Ling-Jun Li, Zhongwei Huang
BMC Medicine.2025;[Epub] CrossRef
Current status of older people with chronic diseases adopting digital health technologies: A scoping review
Chengjin Li, Hansong Wang, Jiajun Yuan, Lili Shi, Yunhao Chen, Zefang Gao, Liebin Zhao, Abilio Oliveira
DIGITAL HEALTH.2025;[Epub] CrossRef
САРКОПЕНІЯ У ПАЦІЄНТІВ ІЗ ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ: СУЧАСНІ ДІАГНОСТИЧНІ КРИТЕРІЇ, МЕХАНІЗМИ РОЗВИТКУ ТА СТРАТЕГІЇ ЛІКУВАННЯ
Лариса Журавльова, Олена Кривоносова, Анна Журавльова
PROBLEMS OF ENDOCRINE PATHOLOGY.2025; 82(2): 54. CrossRef
Mediation effects of age, intramuscular adipose tissue index and serum albumin on survival status in initial dialysis patients
Meng-huan Wu, Yu-ting Gao, Yu-xin Ren, Wen Zhou, Jing Zheng, Shi-mei Hou, Yao Wang, Jing-yuan Cao, Xiao-xu Wang, Yan Yang, Bin Wang, Min Yang, Jing-ting Jiang, Min Li
Renal Failure.2025;[Epub] CrossRef
Associations of circulating apolipoprotein J and myostatin with sarcopenia in older adults with and without type 2 diabetes: a cross-sectional study
Inha Jung, Da-Hye Shin, Hyun Joo Cho, So Young Park, Da Young Lee, Ji Hee Yu, Nan Hee Kim, Minjin Lee, Young-Bum Kim, Ji A Seo
Frontiers in Endocrinology.2025;[Epub] CrossRef
Therapeutic advances in sarcopenia management: From traditional interventions to personalized medicine
Xiangliang Liu, Xinqiao Chen, Jiuwei Cui
Clinical Nutrition.2025; 51: 187. CrossRef
The Potential of SARMs and Antimyostatin Agents in Addressing Lean Body Mass Loss From GLP‐1 Agonists: A Literature Review
Jimmy Wen, Ubaid Ansari, Mouhamad Shehabat, Zaid Ansari, Burhaan Syed, Adam Razick, Daniel Razick, Muzammil Akhtar, Eldo Frezza
Journal of Diabetes.2025;[Epub] CrossRef
Effects of Blood-Glucose Lowering Therapies on Body Composition and Muscle Outcomes in Type 2 Diabetes: A Narrative Review
Ioana Bujdei-Tebeică, Doina Andrada Mihai, Anca Mihaela Pantea-Stoian, Simona Diana Ștefan, Claudiu Stoicescu, Cristian Serafinceanu
Medicina.2025; 61(8): 1399. CrossRef
Vitamin D and Sarcopenia: Implications for Muscle Health
Héctor Fuentes-Barría, Raúl Aguilera-Eguía, Lissé Angarita-Davila, Diana Rojas-Gómez, Miguel Alarcón-Rivera, Olga López-Soto, Juan Maureira-Sánchez, Valmore Bermúdez, Diego Rivera-Porras, Julio Cesar Contreras-Velázquez
Biomedicines.2025; 13(8): 1863. CrossRef
Diabetes and Sarcopenia: Metabolomic Signature of Pathogenic Pathways and Targeted Therapies
Anamaria Andreea Danciu, Cornelia Bala, Georgeta Inceu, Camelia Larisa Vonica, Adriana Rusu, Gabriela Roman, Dana Mihaela Ciobanu
International Journal of Molecular Sciences.2025; 26(15): 7574. CrossRef
Effectiveness of Sodium-Glucose Transporter 2 Inhibitors and Semaglutide on Body Composition in Type 2 Diabetes Mellitus and Chronic Kidney Disease: A Real-World Cohort Study with Bioelectrical Impedance Analysis
Qing Yang, Chunmei Qin, Yanlin Lang, Wenjie Yang, Fenghao Yang, Jia Yang, Ke Liu, Jiamin Yuan, Yutong Zou, Fang Liu
Diabetes, Metabolic Syndrome and Obesity.2025; Volume 18: 2885. CrossRef
Understanding the Role of Sarcopenia and Diet in Diabetes-Related Mortality
Wonjin Kim
CardioMetabolic Syndrome Journal.2025; 5(2): 112. CrossRef
Comparison of SGLT-2i and GLP-1RA on cardiovascular and renal outcomes in elderly patients with T2DM: a single-center retrospective cohort study
Yawei Qin, Xvguang Xv, Liang Cheng, Bin Liu
International Urology and Nephrology.2025;[Epub] CrossRef
The association between living habits, physical activity level and sarcopenia in chinese older adults with type 2 diabetes mellitus: a cross-sectional study
Yiting Yue, Huaping Shen, Hongmei Li, Yongjing Zhang, Yiwei Zhao, Rui Zhang, Xiaoyan Xue
Frontiers in Public Health.2025;[Epub] CrossRef
Phosphoglycerate kinase 1 as a potential biomarker and therapeutic target for diabetic sarcopenia
Fangyu Li, Qingsheng Wang, Rui Li, Yuanyuan Gao, Ying Wang, Qi Chen
QJM: An International Journal of Medicine.2025;[Epub] CrossRef
High “sarcopenia index” reduce all-cause mortality in patients with acute myocardial infarction
Hui Pan, C. Yu Dong, Z. Cheng Yang, Y. Bin Xi, He Lin, J. Lu Zhu, X. Wen Wang, H. Jie Zhan, Z. Hao Wang
Clinical Nutrition.2025; 54: 91. CrossRef
Myosteatosis and Type 2 Diabetes Mellitus
Lucian Batista de Oliveira, Vanessa de Oliveira e Silva, Ítalo Caio Lopes Jucá, João Victor Gonçalves dos Santos Torres, Maria Roseneide dos Santos Torres, Fabio Moura, Francisco Bandeira
Acta Medica (Hradec Kralove, Czech Republic).2025; 68(2): 37. CrossRef
Association between Cardiovascular-Kidney-Metabolic Syndrome and Relative Muscle Loss in American Adults
Cheng-Di Yuan, Bo-Shui Huang, Zhong-Peng Li, Ji-Wei Zhao, Yao-Wei Zhi
International Heart Journal.2025; 66(6): 925. CrossRef
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy
Qianlan Dong, Longhao Dong, Yanting Zhu, Xiaoming Wang, Xiaohui Yan
Functional & Integrative Genomics.2025;[Epub] CrossRef
End-Users’ Perspectives on Implementation Outcomes of Digital Voice Assistants Delivering a Home-Based Lifestyle Intervention in Older Obese Adults with Type 2 Diabetes Mellitus: A Qualitative Analysis
Costas Glavas, Jiani Ma, Surbhi Sood, Elena S. George, Robin M. Daly, Eugene Gvozdenko, Barbora de Courten, David Scott, Paul Jansons
Technologies.2025; 13(11): 511. CrossRef
Current Strategies for Healthy Aging: The Interplay Between Nutrition, Metabolism, and Exercise
Ana Matos, Cezara Tihon, Carolina Costa, Catarina Domingues
Cureus.2025;[Epub] CrossRef
Is the experience of chronic pain different in frail older adults? A cross-sectional exploratory study
Nayara Tasse de Oliveira Cirino, Marcos Paulo Miranda de Aquino, Camila Astolphi Lima, Fânia Cristina dos Santos, Mauricio de Miranda Ventura, Monica Rodrigues Perracini
Arquivos de Neuro-Psiquiatria.2025; 83(10): 001. CrossRef
Ophiopogon japonicus Root Extract Attenuates Obesity-Induced Muscle Atrophy Through Regulation of the PI3K-AKT-mTOR/FoxO3a Signaling Pathway and Lipid Metabolism in Mice and C2C12 Myotubes
Yang Wang, Haifeng Shao, Chenzi Lyu, Kyung Hee Park, Tran Khoa Nguyen, In Jun Yang, Hyo Won Jung, Yong-Ki Park
Nutrients.2025; 17(24): 3946. CrossRef
Clinical Nutrition Strategies for the Prevention and Management of Sarcopenia in Older Adults with Type 2 Diabetes
Sohye Kim
The Journal of Korean Diabetes.2025; 26(4): 238. CrossRef
Fucoidan ameliorates diabetic skeletal muscle atrophy through PI3K/Akt pathway
Caixia Li, Yaping Liu, Mingzhi Yang, Haoyue Huang, Lulu Tang, Yufan Miao, Wenjie Li, Xing Li
Journal of Functional Foods.2024; 114: 106076. CrossRef
Evaluation of the effect of testosterone replacement therapy with a transdermal testosterone on glycemic control in men with type 2 diabetes mellitus
R. V. Rozhivanov, M. O. Chernova, V. A. Ioutsi, G. A. Mel’nichenko, M. V. Shestakova, E. R. Rozhivanova, E. N. Andreeva, N. G. Mokrysheva
Diabetes mellitus.2024; 27(2): 120. CrossRef
Higher dietary live microbe intake is associated with a lower risk of sarcopenia
Kemin Yan, Xiaoyi Ma, Chen Li, Xiang Zhang, Manxuan Shen, Sai Chen, Jia Zhao, Wen He, Hua Hong, Yingying Gong, Gang Yuan
Clinical Nutrition.2024; 43(7): 1675. CrossRef
d-Pinitol Improves Diabetic Sarcopenia by Regulation of the Gut Microbiome, Metabolome, and Proteome in STZ-Induced SAMP8 Mice
Xin Yu, Pei Li, Baoying Li, Fei Yu, Wenqian Zhao, Xue Wang, Yajuan Wang, Haiqing Gao, Mei Cheng, Xiaoli Li
Journal of Agricultural and Food Chemistry.2024; 72(25): 14466. CrossRef
Proteomics Analysis Provides Insights into the Role of Lipid Metabolism in T2DM-Related Sarcopenia
Jingying Wu, Shengnan Wang, Huafeng Zhuang, Weichun Wang, Yaoguo Wang, Youfang Chen, Zhengping Huang, Chunnuan Chen, Xiaofeng Chen
ACS Omega.2024; 9(31): 34056. CrossRef
Age- and sex-dependent associations between self-reported physical activity levels and self-reported cardiovascular risk factors: a population-based cross-sectional survey
Johannes Burtscher, Martin Kopp, Jeannette Klimont, Hanno Ulmer, Barbara Strasser, Martin Burtscher
BMC Public Health.2024;[Epub] CrossRef
Addressing broader dietary patterns and physical activity in the study of dietary live microbe intake and sarcopenia
Chun-Yu Shen, Chen-Pi Li, Hui-Chin Chang, Shuo-Yan Gau
Clinical Nutrition.2024; 43(10): 2388. CrossRef

Original Article

Basic Research
Effects Of Exercise Training And Chlorogenic Acid Supplementation On Hepatic Lipid Metabolism In Prediabetes Mice: Samaneh Shirkhani, Sayyed Mohammad Marandi, Mohammad Hossein Nasr-Esfahani, Seung Kyum Kim; Diabetes Metab J. 2023;47(6):771-783. Published online September 8, 2023; DOI: https://doi.org/10.4093/dmj.2022.0265

7,840 View
222 Download
4 Web of Science
5 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Since prediabetes is a risk factor for metabolic syndromes, it is important to promote a healthy lifestyle to prevent prediabetes. This study aimed to determine the effects of green coffee (GC), chlorogenic acid (CGA) intake, and exercise training (EX) on hepatic lipid metabolism in prediabetes male C57BL/6 mice.
Methods
Forty-nine mice were randomly divided into two groups feeding with a normal diet (n=7) or a high-fat diet (HFD, n=42) for 12 weeks. Then, HFD mice were further divided into six groups (n=7/group): control (pre-D), GC, CGA, EX, GC+EX, and CGA+EX. After additional 10 weeks under the same diet, plasma, and liver samples were obtained.
Results
HFD-induced prediabetes conditions with increases in body weight, glucose, insulin, insulin resistance, and lipid profiles were alleviated in all treatment groups. Acsl3, a candidate gene identified through an in silico approach, was lowered in the pre-D group, while treatments partly restored it. HFD induced adverse alterations of de novo lipogenesis- and β oxidation-associated molecules in the liver. However, GC and CGA supplementation and EX reversed or ameliorated these changes. In most cases, GC or CGA supplementation combined with EX has no synergistic effect and the GC group had similar results to the CGA group.
Conclusion
These findings suggest that regular exercise is an effective non-therapeutic approach for prediabetes, and CGA supplementation could be an alternative to partially mimic the beneficial effects of exercise on prediabetes.

Citations

Citations to this article as recorded by

Stevioside Improves Liver Insulin Resistance in Prediabetic Mice via IRS1/PI3K/AKT Signaling Pathway
Changfa Zhang, Lili Kang, Kangjun Li, Jingyi Zhang, Yingxin Liu, Ruoting Wang, Guowei Li
Molecular Nutrition & Food Research.2025;[Epub] CrossRef
Advances in the research on phenolic acids and flavonoids in vinegar: Sources, formation and degradation mechanisms, and functional properties
Cheng-Hao Jin, Yong-Zhu Zhang, Feng-Hua Wu, Chang-Ling Wu, Peng Wang, Wei Feng, Lin-Mei Liang, Wei-Jiang Xu, Xiao-Tao Sun, Xing-Quan Liu, Guan-Yu Fang
Food Research International.2025; 222: 117702. CrossRef
Integrated Genomic–Metabolomic Analysis for Tri-Categorical Classification of Type 2 Diabetes Status in the Korean Ansan–Ansung Cohort
Junho Cha, Sungkyoung Choi
International Journal of Molecular Sciences.2025; 26(23): 11688. CrossRef
TFEB activator tanshinone IIA and derivatives derived from Salvia miltiorrhiza Bge. Attenuate hepatic steatosis and insulin resistance
Lulu Zheng, Beiyan Li, Anlei Yuan, Shijie Bi, Harrison Puscher, Chaoqun Liu, Liansheng Qiao, Yanjiang Qiao, Shifeng Wang, Yanling Zhang
Journal of Ethnopharmacology.2024; 335: 118662. CrossRef
Research progress on the pharmacological activity and mechanism of chlorogenic acid in alleviating acute kidney injury in sepsis patients
Renke Sun, Hui Su, Kecheng Zhai, Yangmengna Gao, Shangping Fang
Perioperative Precision Medicine.2023;[Epub] CrossRef

Sulwon Lecture 2021

Basic Research
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c): Tae Kwan Yoon, Chan Hee Lee, Obin Kwon, Min-Seon Kim; Diabetes Metab J. 2022;46(3):402-413. Published online May 25, 2022; DOI: https://doi.org/10.4093/dmj.2022.0092

12,937 View
314 Download
19 Web of Science
20 Crossref

Abstract PDF PubReader ePub

Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism. Exercise-related mitohormesis involves reactive oxygen species production, mitochondrial unfolded protein response (UPR^mt), and release of mitochondria-derived peptides (MDPs). MDPs are a group of small peptides encoded by mitochondrial DNA with beneficial metabolic effects. Among MDPs, mitochondrial ORF of the 12S rRNA type-c (MOTS-c) is the most associated with exercise. MOTS-c expression levels increase in skeletal muscles, systemic circulation, and the hypothalamus upon exercise. Systemic MOTS-c administration increases exercise performance by boosting skeletal muscle stress responses and by enhancing metabolic adaptation to exercise. Exogenous MOTS-c also stimulates thermogenesis in subcutaneous white adipose tissues, thereby enhancing energy expenditure and contributing to the anti-obesity effects of exercise training. This review briefly summarizes the mitohormetic mechanisms of exercise with an emphasis on MOTS-c.

Citations

Citations to this article as recorded by

Aerobic exercise and MOTS-c attenuate diabetic myocardial fibrosis via inhibition of the THBS1/TGF-β signaling pathway
Zhiyu Li, Tutu Wang, Yu Fu, Feilong Chen, Shunchang Li
Frontiers in Endocrinology.2026;[Epub] CrossRef
Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion
Yiwei Feng, Zhijian Rao, Xu Tian, Yi Hu, Liantian Yue, Yifan Meng, Qiuling Zhong, Wei Chen, Wenlong Xu, Haoran Li, Yingjia Hu, Rengfei Shi
Free Radical Biology and Medicine.2025; 227: 619. CrossRef
The impact of mitokine MOTS-c administration on the soleus muscle of rats subjected to a 7-day hindlimb suspension
Daria A. Sidorenko, Irina D. Lvova, Sergey A. Tyganov, Boris S. Shenkman, Kristina A. Sharlo
Journal of Muscle Research and Cell Motility.2025; 46(3): 215. CrossRef
Aging-associated Aberrant Mitochondrial Redox Signaling, Physical Activity, and Sarcopenia
Mehmet Can Atayik, Erdem Atasever, Seydanur Turgut, Ufuk Cakatay
Current Aging Science.2025; 18(2): 120. CrossRef
Mitochondria, Sex, and Cardiovascular Disease: A Complex Interplay
Andrea Iboleon-Jimenez, Alberto Contreras-Muñoz, Cristian Peláez-Berdún, Rafael Franco-Hita, Alba Sesmero, Ainhoa Robles-Mezcua, Jose M. García-Pinilla, Manuel Jimenez-Navarro, Mora Murri
International Journal of Molecular Sciences.2025; 26(18): 8971. CrossRef
Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization
RABIE ELHUSSEINY, MOHAMMED IHSAN, MARIEM LABIDI, MARINE ALHAMMOUD, KHOULOUD MTIBAA, NELDA NADER, NADA NASIR, ABDULAZIZ FAROOQ, EMMANOUI PAPAKOSTAS, BRUNO OLORY, FLAVIO CRUZ, PIETER D’HOOGHE, SEBASTIEN RACINAIS, LOUISE DELDICQUE
Medicine & Science in Sports & Exercise.2025; 57(12): 2764. CrossRef
Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives
Satadeepa Kal, Sumana Mahata, Suborno Jati, Sushil K. Mahata
Peptides.2024; 172: 171147. CrossRef
Beneficial Effects of Low-Grade Mitochondrial Stress on Metabolic Diseases and Aging
Se Hee Min, Gil Myoung Kang, Jae Woo Park, Min-Seon Kim
Yonsei Medical Journal.2024; 65(2): 55. CrossRef
Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions
Jie Zhang, Yunfang Gao, Jiangwei Yan
Metabolites.2024; 14(2): 88. CrossRef
The current insights of mitochondrial hormesis in the occurrence and treatment of bone and cartilage degeneration
Wacili Da, Quan Chen, Bin Shen
Biological Research.2024;[Epub] CrossRef
Mitochondria-derived peptide is an effective target for treating streptozotocin induced painful diabetic neuropathy through induction of activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1alpha -mediated mitochondrial b
Lingfei Xu, Xihui Tang, Long Yang, Min Chang, Yuqing Xu, Qingsong Chen, Chen Lu, Su Liu, Jinhong Jiang
Molecular Pain.2024;[Epub] CrossRef
MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated <?A3B2 pi6?>mitochondrial biogenesis
Long Yang, Miaomiao Li, Yucheng Liu, Yang Bai, Tianyu Yin, Yangyang Chen, Jinhong Jiang, Su Liu
Acta Biochimica et Biophysica Sinica.2024; 56(9): 1323. CrossRef
Adipose thermogenic mechanisms by cold, exercise and intermittent fasting: Similarities, disparities and the application in treatment
Linshan Chen, Longhua Liu
Clinical Nutrition.2024; 43(9): 2043. CrossRef
Sedentary Lifestyles and a Hypercaloric Diets During Middle Age, are Binomial Conducive to Fatal Progression, That is Counteracted by the Hormetic Treatment of Exercise, Metformin, and Tert-Butyl Hydroquinone: An Analysis of Female Middle-Aged Rat Liver M
Stefanie Paola López-Cervantes, Rafael Toledo-Pérez, Jaime Abraham De Lira-Sánchez, Giovanni García-Cruz, Mercedes Esparza-Perusquía, Armando Luna-López, Juan Pablo Pardo, Oscar Flores-Herrera, Mina Konigsberg
Dose-Response.2024;[Epub] CrossRef
Antifragility and antiinflammaging: Can they play a role for a healthy longevity?
Fabiola Olivieri, Francesco Prattichizzo, Fabrizia Lattanzio, Anna Rita Bonfigli, Liana Spazzafumo
Ageing Research Reviews.2023; 84: 101836. CrossRef
MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation
Yuejun Zheng, Zilin Wei, Tianhui Wang
Frontiers in Endocrinology.2023;[Epub] CrossRef
MOTS-c: A potential anti-pulmonary fibrosis factor derived by mitochondria
Zewei Zhang, Dongmei Chen, Kaili Du, Yaping Huang, Xingzhe Li, Quwen Li, Xiaoting Lv
Mitochondrion.2023; 71: 76. CrossRef
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
Byung Soo Kong, Changhan Lee, Young Min Cho
Diabetes & Metabolism Journal.2023; 47(3): 315. CrossRef
MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake—A Preliminary Study
Remigiusz Domin, Michał Pytka, Mikołaj Żołyński, Jan Niziński, Marcin Rucinski, Przemysław Guzik, Jacek Zieliński, Marek Ruchała
International Journal of Molecular Sciences.2023; 24(19): 14951. CrossRef
Unique Properties of Apicomplexan Mitochondria
Ian M. Lamb, Ijeoma C. Okoye, Michael W. Mather, Akhil B. Vaidya
Annual Review of Microbiology.2023; 77(1): 541. CrossRef

Review

Metabolic Risk/Epidemiology
Lifestyle Interventions for Non-Obese Patients Both with, and at Risk, of Non-Alcoholic Fatty Liver Disease: Xin-Lei Zhang, Ting-Yao Wang, Giovanni Targher, Christopher D. Byrne, Ming-Hua Zheng; Diabetes Metab J. 2022;46(3):391-401. Published online May 25, 2022; DOI: https://doi.org/10.4093/dmj.2022.0048

11,700 View
322 Download
24 Web of Science
24 Crossref

Abstract PDF PubReader ePub

Non-alcoholic fatty liver disease occurring in non-obese subjects (the so-called non-obese NAFLD) is a highly prevalent but neglected liver condition, which is closely associated with metabolic disorders and suboptimal lifestyles. Landmark studies have shown that lifestyle interventions are potentially beneficial in decreasing the risk of developing non-obese NAFLD and in ameliorating NAFLD in non-obese individuals with pre-existing NAFLD. Lifestyle interventions usually refer to changes in eating habits and physical activity, both of which have a powerful effect on non-obese NAFLD and on risk factors for non-obese NAFLD. However, to date, patients and health-care professionals have a poor awareness and understanding of non-obese NAFLD and the beneficial effects of lifestyle interventions in this patient population. The aim of this narrative review is to briefly discuss the evidence for the effects of lifestyle changes and what changes are needed amongst medical personnel and other stakeholders in order to raise awareness of non-obese NAFLD.

Citations

Citations to this article as recorded by

Long-term outcomes following hepatectomy in patients with lean non-alcoholic fatty liver disease-associated hepatocellular carcinoma versus overweight and obese counterparts: A multicenter analysis
Wei Zhang, Min-Yu Li, Zi-Qiang Li, Yong-Kang Diao, Xing-Kai Liu, Hong-Wei Guo, Xiao-Chang Wu, Hong Wang, Si-Yuan Wang, Ya-Hao Zhou, Jun Lu, Kong-Ying Lin, Wei-Min Gu, Ting-Hao Chen, Jie Li, Ying-Jian Liang, Lan-Qing Yao, Ming-Da Wang, Chao Li, Dong-Xu Yin
Asian Journal of Surgery.2025; 48(1): 150. CrossRef
Lipid profile and non-alcoholic fatty liver disease detected by ultrasonography: is systemic inflammation a necessary mediator?
Wenzhen Li, Feng Wang, Zhimin Li, Wenting Feng, Hongying Huang, Mei-Po Kwan, Lap Ah Tse
Annals of Medicine.2025;[Epub] CrossRef
Targeting Metabolism: Innovative Therapies for MASLD Unveiled
Weixin Wang, Xin Gao, Wentong Niu, Jinping Yin, Kan He
International Journal of Molecular Sciences.2025; 26(9): 4077. CrossRef
Clinical Guidelines of the Russian Society for the Study of the Liver, Russian Gastroenterological Association, Russian Society for the Prevention of Non-Communicable Diseases, Russian Association of Endocrinologists, Russian Scientific Medical Society of
V. T. Ivashkin, O. M. Drapkina, M. V. Maevskaya, K. L. Raikhelson, S. V. Okovityi, M. S. Zharkova, V. R. Grechishnikova, D. I. Abdulganieva, S. A. Alekseenko, M. D. Ardatskaya, I. G. Bakulin, N. V. Bakulina, P. O. Bogomolov, V. V. Breder, E. V. Vinnitskay
Russian Journal of Gastroenterology, Hepatology, Coloproctology.2025; 35(1): 94. CrossRef
Associations between skeletal muscle strength and chronic kidney disease in patients with MASLD
Xin-Lei Zhang, Yeqing Gu, Jing Zhao, Pei-Wu Zhu, Wen-Ying Chen, Gang Li, Wen-Yue Liu, Wen Zheng, Ni Zhang, Li-Li Chen, Giovanni Targher, Christopher D. Byrne, Kaijun Niu, Dan-Qin Sun, Ming-Hua Zheng
Communications Medicine.2025;[Epub] CrossRef
Beyond obesity: lean metabolic dysfunction-associated steatohepatitis from unveiling molecular pathogenesis to therapeutic advancement
Indrajit Bhattacharya, Deep Kumar Maity, Amit Kumar, Sampriti Sarkar, Teeshyo Bhattacharya, Amrita Sahu, Remya Sreedhar, Somasundaram Arumugam
Naunyn-Schmiedeberg's Archives of Pharmacology.2025; 398(10): 13647. CrossRef
Strategies for Mitigating Fatty Liver Disease Risk: A Systematic Review of Policy Interventions
Mohamad Ali Abyazi, Mohammadkarim Bahadori, Parisa Mehdizadeh, Emad Nobahar
Hepatitis Monthly.2025;[Epub] CrossRef
Gut microbiota and metabolomics in metabolic dysfunction-associated fatty liver disease: interaction, mechanism, and therapeutic value
Luyu Wang, Hongtao Wang, Jian Wu, Changyi Ji, Ying Wang, Mengmeng Gu, Miaomiao Li, Hongwei Yang
Frontiers in Cellular and Infection Microbiology.2025;[Epub] CrossRef
Cholecystectomy and non-alcoholic fatty liver disease: Exploring the hidden connection and implications
Xue-Yan Liu, Jing Ma, Yan Jiao
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef
Knowledge, attitude, and practice on dietary management among patients with non-alcoholic fatty liver disease: a cross-sectional study in Sichuan
Li Xu, Shanshan Hu, Ying Ye, Xiaoli Xie, Pinghui Zhou, Hong Shen, Xiaochen Zhao
BMC Public Health.2025;[Epub] CrossRef
Triglycerides Mediate the Influence of Body Mass Index on Non-Alcoholic Fatty Liver Disease in a Non-Obese Chinese Population with Normal Low-Density Lipoprotein Cholesterol Levels
Xixi Han, Jingwen Kong, Hemin Zhang, Yuan Zhao, Yafeng Zheng, Chao Wei
Obesity Facts.2024; 17(2): 191. CrossRef
AI‐based digital pathology provides newer insights into lifestyle intervention‐induced fibrosis regression in MASLD: An exploratory study
Hai‐Yang Yuan, Xiao‐Fei Tong, Ya‐Yun Ren, Yang‐Yang Li, Xin‐Lei Wang, Li‐Li Chen, Sui‐Dan Chen, Xiao‐Zhi Jin, Xiao‐Dong Wang, Giovanni Targher, Christopher D. Byrne, Lai Wei, Vincent W.‐S Wong, Dean Tai, Arun J. Sanyal, Hong You, Ming‐Hua Zheng
Liver International.2024; 44(10): 2572. CrossRef
Current strategies for nonalcoholic fatty liver disease treatment (Review)
Jing Sun, Xiuli Jin, Yiling Li
International Journal of Molecular Medicine.2024;[Epub] CrossRef
Lifestyle deterioration linked to elevated inflammatory cytokines over a two-month follow-up
Kai Guo, Xuejiao Zeng, Xiaoming Liu, Panpan He, Zhiwei Zhang, Qianwen Yang, Lei Wang, Lipeng Jing
Scientific Reports.2024;[Epub] CrossRef
Exploration of the potential mechanism of aqueous extract of Artemisia capillaris for the treatment of non-alcoholic fatty liver disease based on network pharmacology and experimental verification
Meng Liang, Siyu Dong, Yi Guo, Yuyi Zhang, Xiao Xiao, Jun Ma, Xiaowen Jiang, Wenhui Yu
Journal of Pharmacy and Pharmacology.2024; 76(10): 1328. CrossRef
Meta-analysis of randomized controlled trials of the effects of synbiotics, probiotics, or prebiotics in controlling glucose homeostasis in non-alcoholic fatty liver disease patients
Siqi Ding, Qing Hong, Yuanyue Yao, Minwen Gu, Jie Cui, Wenhui Li, Jian Zhang, Chengcheng Zhang, Jinchi Jiang, Yonghong Hu
Food & Function.2024; 15(19): 9954. CrossRef
Investigation of the mechanism by which Tegillarca granosa polysaccharide regulates non-alcoholic fatty liver disease in mice by modulating Lactobacillus Johnsonii
Hanwen Zhang, Xingwen Yang, Jinyu Chen, Qihong Jiang, Shiwei Yao, Lin Chen, Xingwei Xiang
International Journal of Biological Macromolecules.2024; 282: 137259. CrossRef
Patients with NAFLD exhibit more advanced fibrosis in liver biopsy than patients with other chronic liver diseases
Lydia Rohr, Peter Lemmer, Marie Henning, Andrea Tannapfel, Theodor Baars, Paul Manka, Ali Canbay, Jan-Peter Sowa
Zeitschrift für Gastroenterologie.2023; 61(01): 29. CrossRef
Performance of Simple Fibrosis Score in Non-Alcoholic Fatty Liver Disease with and without Type 2 Diabetes
Seung Min Chung, Min Kyu Kang, Jun Sung Moon, Jung Gil Park
Endocrinology and Metabolism.2023; 38(2): 277. CrossRef
An international multidisciplinary consensus statement on MAFLD and the risk of CVD
Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Virend Somers, Seung Up Kim, C. Anwar A. Chahal, Vincent Wai-Sun Wong, Jingjing Cai, Michael D. Shapiro, Mohammed Eslam, Philippe Gabriel Steg, Ki-Chul Sung, Anoop Misra, Jian-Jun Li, Carlos Brotons,
Hepatology International.2023; 17(4): 773. CrossRef
Lean or Non-obese Nonalcoholic Fatty Liver Disease Patients: Are They Really Lean?
Eugene Han, Yong-ho Lee
Clinical and Molecular Hepatology.2023; 29(4): 980. CrossRef
Sex-Based Differences and Risk Factors for Comorbid Nonalcoholic Fatty Liver Disease in Patients with Bipolar Disorder: A Cross-Sectional Retrospective Study
Ying Wang, Yiyi Liu, Xun Zhang, Qing Wu
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3533. CrossRef
Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity
Valeria Calcaterra, Vittoria Magenes, Matteo Vandoni, Clarissa Berardo, Luca Marin, Alice Bianchi, Erika Cordaro, Giustino Silvestro, Dario Silvestri, Vittoria Carnevale Pellino, Cristina Cereda, Gianvincenzo Zuccotti
Children.2022; 9(8): 1174. CrossRef
The effects of supplementation of probiotics, prebiotics, or synbiotics on patients with non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials
Wenmin Xing, Wenyan Gao, Xiaoling Lv, Zhenlei Zhao, Genxiang Mao, Xiaoyan Dong, Zuyong Zhang
Frontiers in Nutrition.2022;[Epub] CrossRef

Original Articles

Lifestyle
Effectiveness of Resistance Exercise on Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Systematic Review with Meta-Analysis: Rubén Fernández-Rodríguez, Sonia Monedero-Carrasco, Bruno Bizzozero-Peroni, Miriam Garrido-Miguel, Arthur Eumann Mesas, Vicente Martínez-Vizcaíno; Diabetes Metab J. 2023;47(1):118-134. Published online April 29, 2022; DOI: https://doi.org/10.4093/dmj.2022.0007

19,852 View
433 Download
23 Web of Science
25 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Type 2 diabetes mellitus (T2DM) is related to increased inflammatory processes. The effects of resistance exercise on inflammatory biomarkers in T2DM are controversial. Our purpose was to determine the effectiveness of resistance exercise on inflammatory biomarkers in patients diagnosed with T2DM.
Methods
We searched four databases until September 2021. We included randomized clinical trials (RCTs) of the effects of resistance exercise on inflammatory biomarkers (C-reactive protein [CRP], tumor necrosis factor alpha, interleukin-6, and interleukin-10) in patients with T2DM. A random effects meta-analysis was conducted to determine the standardized mean difference (SMD) and the raw mean difference (MD) for CRP.
Results
Thirteen RCTs were included in the review, and 11 in the meta-analysis for CRP. Lower CRP levels were observed when resistance exercise was compared with the control groups (SMD=–0.20; 95% confidence interval [CI], –0.37 to –0.02). When conducting the MD meta-analysis, resistance exercise showed a significant decrease in CRP of –0.59 mg/dL (95% CI, –0.88 to –0.30); otherwise, in the control groups, the CRP values increased 0.19 mg/dL (95% CI, 0.17 to 0.21).
Conclusion
Evidence supports resistance exercise as an effective strategy to manage systemic inflammation by decreasing CRP levels in patients with T2DM. The evidence is still inconclusive for other inflammatory biomarkers.

Citations

Citations to this article as recorded by

Inflammation biomarker and physical exercise: A bibliometric study
Andi Sri Dewi Anggraeni M, Ulfah Widyastuti Arsal, Andi Ainun Zulkiah Surur
BIO Web of Conferences.2026; 217: 02005. CrossRef
Exercise Interventions for the Prevention and Treatment of Anthracycline-Induced Cardiotoxicity in Women with Breast Cancer: A Systematic Review
Hongmei Li, Haiyun Liu, Boliang Wang, Xiao Jia, Jingjing Yu, Yurong Zhang, Die Sang, Yimin Zhang
Journal of Science in Sport and Exercise.2025; 7(1): 14. CrossRef
Predictors of Resistance Training Behavior among Glucagon-like Peptide 1 Medication Users
Justin M. Kompf, Ryan E. Rhodes
Translational Journal of the American College of Sports Medicine.2025;[Epub] CrossRef
Comparative Efficacy of Different Exercise Modes on Inflammatory Markers in Patients With Type 2 Diabetes Mellitus: A Systematic Review With Pairwise and Network Meta‐Analyses
Mousa Khalafi, Aref Habibi Maleki, Michael E. Symonds, Karim Azali Alamdari, Mahsa Ehsanifar, Sara K. Rosenkranz
Obesity Reviews.2025;[Epub] CrossRef
Effect of heat therapy compared with strength training on metabolic profile, heat shock response, inflammation, cardiovascular responses and microbiota in individuals with type 2 diabetes: study protocol of a randomized trial
Patrícia Martins Bock, Lucas Stahlhöfer Kowalewski, Layane Ramos Ayres, Mariana Kras Borges Russo, Gabriela Tomedi Leites, Andreza Francisco Martins, Álvaro Reischak de Oliveira, Mauricio Krause
Sao Paulo Medical Journal.2025;[Epub] CrossRef
The impact of exercise on chronic systemic inflammation: a systematic review and meta–meta-analysis
Olga Magni, Giannis Arnaoutis, Demosthenes Panagiotakos
Sport Sciences for Health.2025; 21(3): 1405. CrossRef
Risk of End-Stage Kidney Disease in Individuals with Diabetes Living Alone: A Large-Scale Population-Based Study
Kyunghun Sung, Jae-Seung Yun, Bongseong Kim, Hun-Sung Kim, Jae-Hyoung Cho, Yong-Moon Mark Park, Kyungdo Han, Seung-Hwan Lee
Diabetes & Metabolism Journal.2025; 49(4): 862. CrossRef
Impact of home-based multi-task exercise training on executive function and TNF/IL-10 ratio in postmenopausal women with diabetes
A. Jamali, M. Molanouri Shamsi, M. Behmanesh, A. Kouhkan, P. Hassani-Abharian, M. Pourmohammad, R. Negaresh, H. Adibi, S. Soudi
Cytokine.2025; 194: 157001. CrossRef
Physical activity for prevention of cardiovascular disease: consensus statement of Korean Society of Cardio-cerebrovascular Disease Prevention
Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee
The Korean Journal of Internal Medicine.2025; 40(5): 696. CrossRef
The Anti-Inflammatory Effects of Resistance Training in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Nikolaos P. E. Kadoglou, Chrysostomos Georgiou, Nikolaos Balaskas, Chrystalla Panayiotou, Michail Vardas, Andreas Mitsis, Constantine N. Antonopoulos
Biomolecules.2025; 15(10): 1417. CrossRef
Physical activity for prevention of cardiovascular disease: a consensus statement of the Korean Society of Cardio-cerebrovascular Disease Prevention
Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee
Cardiovascular Prevention and Pharmacotherapy.2025; 7(4): 120. CrossRef
Resistance Training Improves Hemodynamics Involving Autonomic and Immune Responses
Eduarda Teodora Rachid-Wolpp, Boris Brill, Anamei Silva Reis, Meiry Souza Moura-Maia, Naiara Nadia Moreira-Silva, Mariana Alvarez-Souza, Max Silva-Sousa, Elano Silva-Sousa, Fernanda Rodrigues Monteiro, André Luis Lacerda Bachi, Luis V F de Oliveira, Yanes
International Journal of Sports Medicine.2025;[Epub] CrossRef
Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis
Wei Feng, Yanzhong Wang, Xin Gu, Duonan Yu, Zhiwei Liu
BMC Sports Science, Medicine and Rehabilitation.2025;[Epub] CrossRef
Körperliche Aktivität und Trainingstherapie bei Typ-2-Diabetes – ein Update
Andreas M. Nieß, Ansgar Thiel
Diabetologie und Stoffwechsel.2024; 19(01): 38. CrossRef
Genetic predisposition, lifestyle inflammation score, food-based dietary inflammatory index, and the risk for incident diabetes: Findings from the KoGES data
Hye Ah Lee, Hyesook Park, Bomi Park
Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(3): 642. CrossRef
Associations of meeting 24-h movement guidelines and metabolic syndrome in Korean adults during the COVID-19 pandemic
S.W. Shin, Y. Choi, Y.H. Kang, J. Kim
Public Health.2024; 227: 187. CrossRef
Association of hypoglycemic events with cognitive impairment in patients with type 2 diabetes mellitus: Protocol for a dose-response meta-analysis
Min Ye, Ai Hong Yuan, Qi Qi Yang, Qun Wei Li, Fei Yue Li, Yan Wei, Muhammad Shahzad Aslam
PLOS ONE.2024; 19(2): e0296662. CrossRef
Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials
Jingxian Xue, Xi Han, Yan Zheng, Qiuxia Zhang, Lingyu Kong
Frontiers in Immunology.2024;[Epub] CrossRef
Low-Intensity Resistance Exercise in Cardiac Rehabilitation: A Narrative Review of Mechanistic Evidence and Clinical Implications
Jemima Jansen, Paul W. Marshall, Jocelyne R. Benatar, Rebecca Cross, Tia K. Lindbom, Michael Kingsley
Journal of Clinical Medicine.2024; 13(23): 7338. CrossRef
Long-term impact of adherence to muscle-strengthening guidelines on inflammation markers: a 17-year follow-up study with obesity parameters as mediators
Antonio Garcia-Hermoso, Yasmin Ezzatvar, Rodrigo Yáñez-Sepúlveda, Jorge Olivares-Arancibia, Jacqueline Páez-Herrera, José Francisco López-Gil
BMJ Open Sport & Exercise Medicine.2024; 10(4): e002229. CrossRef
Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study
Eyun Song, Soon Young Hwang, Min Jeong Park, Ahreum Jang, Kyeong Jin Kim, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
Metabolism.2023; 148: 155678. CrossRef
Endothelial progenitor cell response to a multicomponent exercise training program in adults with cardiovascular risk factors
Suiane Cavalcante, Manuel Teixeira, Marisol Gouveia, Ana Duarte, Miriam Ferreira, Maria I. Simões, Maria Conceição, Mariana Costa, Ilda P. Ribeiro, Ana Cristina Gonçalves, José Oliveira, Fernando Ribeiro
German Journal of Exercise and Sport Research.2023; 53(2): 225. CrossRef
“Does Physical Exercise Promote Health Benefits for Diabetic Patients during the COVID-19 Pandemic?”: A Systematic Review
Erivaldo de Souza, Daniela Meneses-Santos, Josué Cruz Santos, Felipe J. Aidar, Carla Roberta de Oliveira Carvalho, Jymmys Lopes dos Santos, Anderson Carlos Marçal
Sports.2023; 11(10): 192. CrossRef
Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis
Liang Tan, Weihua Yan, Weilin Yang, Agata Kamionka, Mariusz Lipowski, Zijian Zhao, Gang Zhao
Experimental Gerontology.2023; 183: 112310. CrossRef
Resistance Training Improves Beta Cell Glucose Sensing and Survival in Diabetic Models
Gabriela Alves Bronczek, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, José Maria Costa-Júnior
International Journal of Molecular Sciences.2022; 23(16): 9427. CrossRef

Lifestyle
Changes in Patterns of Physical Activity and Risk of Heart Failure in Newly Diagnosed Diabetes Mellitus Patients: Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee; Diabetes Metab J. 2022;46(2):327-336. Published online November 24, 2021; DOI: https://doi.org/10.4093/dmj.2021.0046

9,583 View
268 Download
11 Web of Science
14 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
Exercise is recommended for type 2 diabetes mellitus (T2DM) patients to prevent cardiovascular disease. However, the effects of physical activity (PA) for reducing the risk of heart failure (HF) has yet to be elucidated. We aimed to assess the effect of changes in patterns of PA on incident HF, especially in newly diagnosed diabetic patients.
Methods
We examined health examination data and claims records of 294,528 participants from the Korean National Health Insurance Service who underwent health examinations between 2009 and 2012 and were newly diagnosed with T2DM. Participants were classified into the four groups according to changes in PA between before and after the diagnosis of T2DM: continuously inactive, inactive to active, active to inactive, and continuously active. The development of HF was analyzed until 2017.
Results
As compared with those who were continuously inactive, those who became physically active after diagnosis showed a reduced risk for HF (adjusted hazard ratio [aHR], 0.79; 95% confidence interval [CI], 0.66 to 0.93). Those who were continuously active had the lowest risk for HF (aHR, 0.77; 95% CI, 0.62 to 0.96). As compared with those who were inactive, those who exercised regularly, either performing vigorous or moderate PA, had a lower HF risk (aHR, 0.79; 95% CI, 0.69 to 0.91).
Conclusion
Among individuals with newly diagnosed T2DM, the risk of HF was reduced in those with higher levels of PA after diagnosis was made. Our results suggest either increasing or maintaining the frequency of PA after the diagnosis of T2DM may lower the risk of HF.

Citations

Citations to this article as recorded by

Global, regional, and national burden of major diabetes-related complications attributable to physical inactivity
Jayne Feter, Natan Feter, Rodrigo Leal-Menezes, Pedro C. Hallal, Daniel Umpierre
Journal of Sport and Health Science.2026; : 101123. CrossRef
Life-course obesity and heart failure: a two-sample Mendelian randomization study
Haili Wang, Jie Min, Lei Zhong, Jinyu Zhang, Lili Ye, Chunrong Chen
Internal and Emergency Medicine.2025; 20(1): 171. CrossRef
Critical Appraisal of Pharmaceutical Therapy in Diabetic Cardiomyopathy—Challenges and Prospectives
Elina Khattab, Michaelia Kyriakou, Elena Leonidou, Stefanos Sokratous, Angeliki Mouzarou, Michael M. Myrianthefs, Nikolaos P. E. Kadoglou
Pharmaceuticals.2025; 18(1): 134. CrossRef
Sitagliptin, diabetes mellitus, and heart failure: an in-depth review of sitagliptin therapy and heart failure in patients with diabetes mellitus
Mohammadjavad Sotoudeheian, Seyed-Mohamad-Sadegh Mirahmadi, Pedram Salehi Darjani, Mohammad Moradi, Mohammad Pirhayati, Mohammad Sedigh Dakkali, Mehdi Taghizadeh, Reza Azarbad, Hamidreza Pazoki Toroudi
Diabetology International.2025; 16(2): 237. CrossRef
Exploring the Lack of Physical Activity among Adolescents Worldwide
Dalmacito A. Cordero Jr.
Diabetes & Metabolism Journal.2025; 49(3): 513. CrossRef
Physical activity for prevention of cardiovascular disease: consensus statement of Korean Society of Cardio-cerebrovascular Disease Prevention
Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee
The Korean Journal of Internal Medicine.2025; 40(5): 696. CrossRef
Physical activity for prevention of cardiovascular disease: a consensus statement of the Korean Society of Cardio-cerebrovascular Disease Prevention
Ye Seul Yang, Eu Jeong Ku, Seung-Hyun Ko, Eun-Jung Rhee, Sang-Hyun Ihm, Sung Hee Choi, Won-Young Lee
Cardiovascular Prevention and Pharmacotherapy.2025; 7(4): 120. CrossRef
Associations Between Physical Activity and the Risk of Hip Fracture Depending on Glycemic Status: A Nationwide Cohort Study
Kyoung Min Kim, Kyoung Jin Kim, Kyungdo Han, Yumie Rhee
The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1194. CrossRef
Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study
Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim
BMC Medicine.2024;[Epub] CrossRef
Dose-Response Relationship Between Physical Activity and the Morbidity and Mortality of Cardiovascular Disease Among Individuals With Diabetes: Meta-Analysis of Prospective Cohort Studies
Yang Chen, Xingsheng Jin, Guochong Chen, Ru Wang, Haili Tian
JMIR Public Health and Surveillance.2024; 10: e54318. CrossRef
Evaluation and Management of Patients With Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
International Journal of Heart Failure.2023; 5(1): 1. CrossRef
Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Diabetes & Metabolism Journal.2023; 47(1): 10. CrossRef
Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults
Eun Roh, Soon Young Hwang, Eyun Song, Min Jeong Park, Hye Jin Yoo, Sei Hyun Baik, Miji Kim, Chang Won Won, Kyung Mook Choi
Scientific Reports.2022;[Epub] CrossRef
The associations between changes in hepatic steatosis and heart failure and mortality: a nationwide cohort study
Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, Sang-Man Jin, Jae Hyeon Kim
Cardiovascular Diabetology.2022;[Epub] CrossRef

Metabolic Risk/Epidemiology
Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018: Jiun Chae, Moon Young Seo, Shin-Hye Kim, Mi Jung Park; Diabetes Metab J. 2021;45(6):880-889. Published online July 6, 2021; DOI: https://doi.org/10.4093/dmj.2020.0185

10,932 View
290 Download
26 Web of Science
27 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Background
There is a lack of recent research on the changes in risk factors for metabolic syndrome (MetS) in the Asian pediatric population. We aimed to determine the 12-year trends in the prevalence of MetS and relevant lifestyle factors such as smoking, exercise, and calorie intake among Korean adolescents.
Methods
We investigated trends in MetS and lifestyle factors among 6,308 adolescents aged 12 to 18 years from the Korea National Health and Nutrition Examination Survey, 2007 to 2018.
Results
The prevalence of MetS was stable from 2007 to 2018 (1.7% to 2.2%). There were significant increases in the prevalence of central obesity (from 8.1% to 11.2%, P=0.012) and hyperglycemia (from 5.3% to 10.4%, P<0.001) and decreases in hypo-high-density lipoprotein (HDL)-cholesterolemia (from 22.4% to 14.8%, P<0.001). Total calorie intake and calorie intake from fat significantly increased (P<0.001), whereas calorie intake from carbohydrates significantly decreased (P<0.001) during the study period. The proportions of tobacco smokers and regular walkers significantly decreased from 2007 to 2018. After controlling for all covariates, total calorie intake was positively correlated with waist circumference (P<0.05). HDL-cholesterol was negatively associated with carbohydrate consumption (P<0.01) and positively associated with fat consumption (P<0.001). Regular walking and regular strength training were associated with lower waist circumference (P<0.05). Smoking was associated with lower fasting glucose levels (P<0.01).
Conclusion
Although the prevalence rate of MetS is stable among Korean adolescents, the prevalence of central obesity and hyperglycemia has increased greatly in the recent decade. Public education on proper dietary intake and lifestyle modification is required.

Citations

Citations to this article as recorded by

Association between vitamin D status and insulin resistance in Korean adolescents: differential effects of obesity using non-insulin-based indices
Eunji Mun, Kyung Hee Kim, Jung Eun Choi, Hyesook Park, Hye Ah Lee, Hae Soon Kim
BMC Pediatrics.2026;[Epub] CrossRef
National Trends of Vascular Risk Factor Control Among Stroke Survivors in Korea: From the National Health and Nutrition Examination Survey 2010 to 2021
Eung-Joon Lee, Han-Yeong Jeong, Keun-Hwa Jung
Journal of Korean Medical Science.2025;[Epub] CrossRef
Concentrations of Serum Per- and Polyfluoroalkyl Substances and Lipid Health in Adolescents: A Cross-Sectional Study from the Korean National Environmental Health Survey 2018–2020
Min-Won Shin, Habyeong Kang, Shin-Hye Kim
Toxics.2025; 13(2): 91. CrossRef
Hidden link between endocrine-disrupting chemicals and pediatric obesity
Min Won Shin, Shin-Hye Kim
Clinical and Experimental Pediatrics.2025; 68(3): 199. CrossRef
Association between mothers’ working hours and metabolic syndrome in children and adolescents: data from the Korea National Health and Nutrition Examination Survey, 2016–2020
Myoung-hye Lee, Joo-Eun Jeong, Hoon-Ki Park, Hwan-Sik Hwang, Kye-Yeung Park
Korean Journal of Family Medicine.2025; 46(2): 84. CrossRef
Age-related insulin resistance changes in children and adolescents and its impact on the accuracy of diagnosis of metabolic syndrome
Insung Kim, Kyu-Na Lee, Juyoung Sung, Yoon Ji Ahn, Minji Im, Kyungdo Han, Sung Yoon Cho
Annals of Pediatric Endocrinology & Metabolism.2025; 30(4): 213. CrossRef
Binational comparison of the association between socioeconomic status and metabolic syndrome: A nationally representative study in South Korea and the United States
Yoon Lee, Ye Won Kim, Juyeong Kim, André Hajek, Yusheng Li, Jiyoung Hwang, Selin Woo, Dong Keon Yon
Preventive Medicine Reports.2025; 60: 103298. CrossRef
Relationship between sedentary time and cognitive decline in hypertensive patients-mediating role of the weight-adjusted waist circumference index
Mengdi Zhang, Donghai Liu, Shunxin Lv, Cong Wang, Huachen Jiao
Scientific Reports.2025;[Epub] CrossRef
Impact of Overseas Deployment on Fatty Liver and Metabolic Diseases Among Korean Soldiers
Chang In Han, Jaejun Lee
Military Medicine.2024; 189(7-8): e1621. CrossRef
The impacts of dietary sphingomyelin supplementation on metabolic parameters of healthy adults: a systematic review and meta-analysis of randomized controlled trials
Chen-Zi Li, Li-Mei Wu, Chen-Xi Zhu, Huan-Yu Du, Guo-Xun Chen, Fang Yang
Frontiers in Nutrition.2024;[Epub] CrossRef
Association between Thyroid Function and Insulin Resistance Indices in Korean Adolescents: Findings from the 2014–2015 Korea National Health and Nutrition Examination Survey
Eunji Mun, Hye Ah Lee, Jung Eun Choi, Rosie Lee, Kyung Hee Kim, Hyesook Park, Hae Soon Kim
Children.2024; 11(3): 370. CrossRef
The Association Between Obesity Measures and Metabolic Syndrome Risk in Korean Adolescents Aged 10–18 Years
Munku Song, Seamon Kang, Hyunsik Kang
Journal of Multidisciplinary Healthcare.2024; Volume 17: 1769. CrossRef
Harnessing Metabolic Indices as a Predictive Tool for Cardiovascular Disease in a Korean Population without Known Major Cardiovascular Event
Hyun-Jin Kim, Byung Sik Kim, Yonggu Lee, Sang Bong Ahn, Dong Wook Kim, Jeong-Hun Shin
Diabetes & Metabolism Journal.2024; 48(3): 449. CrossRef
Estimated pulse wave velocity as a forefront indicator of developing metabolic syndrome in Korean adults
Hyun-Jin Kim, Byung Sik Kim, Dong Wook Kim, Jeong-Hun Shin
The Korean Journal of Internal Medicine.2024; 39(4): 612. CrossRef
Ongoing increasing trends in central precocious puberty incidence among Korean boys and girls from 2008 to 2020
Sinyoung Kang, Mi Jung Park, Jung Min Kim, Jin-Sung Yuk, Shin-Hye Kim, Jun Mori
PLOS ONE.2023; 18(3): e0283510. CrossRef
The association between urinary cotinine level and metabolic syndrome profiles among adolescents: findings from the Ewha Birth and growth study
Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Seunghee Jun, Bomi Park, Hye Ah Lee, Hae Soon Kim, Hyesook Park
BMC Public Health.2023;[Epub] CrossRef
Artificial Intelligence-Based Speech Analysis System for Medical Support
Eui-Sun Kim, Dong Jin Shin, Sung Tae Cho, Kyung Jin Chung
International Neurourology Journal.2023; 27(2): 99. CrossRef
The effect of hypothalamic involvement and growth hormone treatment on cardiovascular risk factors during the transition period in patients with childhood-onset craniopharyngioma
Sang Hee Park, Yun Jeong Lee, Jung-Eun Cheon, Choong Ho Shin, Hae Woon Jung, Young Ah Lee
Annals of Pediatric Endocrinology & Metabolism.2023; 28(2): 107. CrossRef
Increase of Prevalence of Obesity and Metabolic Syndrome in Children and Adolescents in Korea during the COVID-19 Pandemic: A Cross-Sectional Study Using the KNHANES
Jung Eun Choi, Hye Ah Lee, Sung Won Park, Jung Won Lee, Ji Hyen Lee, Hyesook Park, Hae Soon Kim
Children.2023; 10(7): 1105. CrossRef
The Prevalence of Abdominal Obesity and Metabolic Syndrome in Korean Children and Adolescents
Ja Hyang Cho
Journal of Obesity & Metabolic Syndrome.2023; 32(2): 103. CrossRef
Temporal Trends of the Prevalence of Abdominal Obesity and Metabolic Syndrome in Korean Children and Adolescents between 2007 and 2020
Jieun Lee, Sung-Chan Kang, Obin Kwon, Seung-sik Hwang, Jin Soo Moon, Hyun Wook Chae, Jaehyun Kim
Journal of Obesity & Metabolic Syndrome.2023; 32(2): 170. CrossRef
Changes in the Number of Children and Adolescents with Complex Chronic Conditions and Medical Spending: Analyzing National Health Insurance Claims Data from 2011 to 2021
Jeong-Yoon Oh, Su-Jin Cho, Jin-Seon Jung, Jin-Suk Cho, Choon-Seon Park
Health Insurance Review & Assessment Service Research.2023; 3(2): 155. CrossRef
Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018 (Diabetes Metab J 2021;45:880-9)
Dae Jung Kim
Diabetes & Metabolism Journal.2022; 46(2): 349. CrossRef
Trends and Risk Factors of Metabolic Syndrome among Korean Adolescents, 2007 to 2018 (Diabetes Metab J 2021;45:880-9)
Jiun Chae, Moon Young Seo, Shin-Hye Kim, Mi Jung Park
Diabetes & Metabolism Journal.2022; 46(2): 351. CrossRef
Comprehensive Understanding for Application in Korean Patients with Type 2 Diabetes Mellitus of the Consensus Statement on Carbohydrate-Restricted Diets by Korean Diabetes Association, Korean Society for the Study of Obesity, and Korean Society of Hyperte
Jong Han Choi, Jee-Hyun Kang, Suk Chon
Diabetes & Metabolism Journal.2022; 46(3): 377. CrossRef
Environmental polycyclic aromatic hydrocarbon exposure in relation to metabolic syndrome in US adults
Xue Yang, Qingping Xue, Ying Wen, Yichao Huang, Yi Wang, Gaga Mahai, Tong Yan, Yanjun Liu, Tao Rong, Yixin Wang, Da Chen, Shuqin Zeng, Chun-Xia Yang, Xiong-Fei Pan
Science of The Total Environment.2022; 840: 156673. CrossRef
Commentary on "Single point insulin sensitivity estimator for predicting type 2 diabetes mellitus in obese adolescents"
Shin-Hye Kim
Annals of Pediatric Endocrinology & Metabolism.2022; 27(3): 155. CrossRef

Others
Can Habitual Exercise Help Reduce Serum Concentrations of Lipophilic Chemical Mixtures? Association between Physical Activity and Persistent Organic Pollutants: Yu-Mi Lee, Ji-Yeon Shin, Se-A Kim, David R. Jacobs, Duk-Hee Lee; Diabetes Metab J. 2020;44(5):764-774. Published online May 11, 2020; DOI: https://doi.org/10.4093/dmj.2019.0158

9,100 View
98 Download
10 Web of Science
13 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs), have emerged as a new risk factor of many chronic diseases. As serum concentrations of POPs in humans are mainly determined by both their release from adipose tissue to circulation and their elimination from circulation, management of these internal pathways may be important in controlling the serum concentrations of POPs. As habitual physical activity can increase the elimination of POPs from circulation, we evaluated whether chronic physical activity is related to low serum POP concentrations.

Methods

A cross-sectional study of 1,850 healthy adults (age ≥20 years) without cardio-metabolic diseases who participated in the U.S. National Health and Nutrition Examination Survey 1999 to 2004 was conducted. Information on moderate or vigorous leisure-time physical activity was obtained based on questionnaires. Serum concentrations of OCPs and polychlorinated biphenyls were investigated as typical POPs.

Results

Serum concentrations of OCPs among physically active subjects were significantly lower than those among physically inactive subjects (312.8 ng/g lipid vs. 538.0 ng/g lipid, P<0.001). This difference was maintained after adjustment for potential confounders. When analyses were restricted to physically active subjects, there were small decreases in the serum concentrations of OCPs with increasing duration of physical activity, showing a curvilinear relationship over the whole range of physical activity (P_quadratic <0.001). In analyses stratified by age, sex, body mass index, and smoking status, a strong inverse association was similarly observed among all subgroups.

Conclusion

Physical activity may assist in decreasing serum concentrations of lipophilic chemical mixtures such as OCPs.

Citations

Citations to this article as recorded by

Associations between per- and polyfluoroalkyl substances and menstrual cycle regularity in reproductive-aged female: A cross-sectional study
Aiqin Qiu, Kai Luo, Huan Liu, Jialing Huang, Xiaotu Liu, Jun Zhang, Da Chen, Weiwei Cheng, Wei Huang
Emerging Contaminants.2025; 11(1): 100438. CrossRef
Association of Human Milk Dioxin Like-POPs Levels with Maternal Characteristics and Newborn Anthropometric Measurements: A Cross-sectional Study from Southern India
Amala Varghese, Rahul M. Chirackal, V. C. Manoj, C. Kesavachandran, K. P. Prathish
Exposure and Health.2025; 17(4): 1047. CrossRef
Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review
Quentin A. Serrano, Sébastien Le Garf, Vincent Martin, Serge S. Colson, Nicolas Chevalier
International Journal of Molecular Sciences.2024; 25(2): 883. CrossRef
Untargeted metabolomics reveal signatures of a healthy lifestyle
Wimal Pathmasiri, Blake R. Rushing, Susan McRitchie, Mansi Choudhari, Xiuxia Du, Alexsandr Smirnov, Matteo Pelleigrini, Michael J. Thompson, Camila A. Sakaguchi, David C. Nieman, Susan J. Sumner
Scientific Reports.2024;[Epub] CrossRef
Unraveling the pesticide-diabetes connection: A case-cohort study integrating Mendelian randomization analysis with a focus on physical activity's mitigating effect
Dandan Wei, Jiayu Shi, Zhiwei Chen, Haoran Xu, Xuyan Wu, Yao Guo, Xin Zen, Caini Fan, Xiaotian Liu, Jian Hou, Wenqian Huo, Linlin Li, Tao Jing, Chongjian Wang, Zhenxing Mao
Ecotoxicology and Environmental Safety.2024; 283: 116778. CrossRef
Prospective study on the joint effect of persistent organic pollutants and glucose metabolism on chronic kidney disease: Modifying effects of lifestyle interventions
Dandan Wei, Jiayu Shi, Haoran Xu, Yao Guo, Xueyan Wu, Zhiwei Chen, Taimeng Chen, Huilin Lou, Erbao Han, Guozhen Han, Yumeng Yan, Xiaotian Liu, Xin Zeng, Caini Fan, Jian Hou, Wenqian Huo, Linlin Li, Tao Jing, Chongjian Wang, Zhenxing Mao
Science of The Total Environment.2024; 951: 175694. CrossRef
Associations between polychlorinated biphenyls and cancer risk among type 2 diabetes: The modifying effects of lifestyle
Peiwen Li, Yu Wang, Qianying Liu, Yan Yan, Zhuoya Zhao, Shiyang Zhang, Chengyong Jia, Jun An, Cheng Xu, Xin Zhang, Tao Jing, Huan Guo, Meian He
Chemosphere.2024; 366: 143442. CrossRef
Physical exercise and persistent organic pollutants
Chang Liu, Hui sheng Hou
Heliyon.2023; 9(9): e19661. CrossRef
Exposure to a low concentration of mixed organochlorine pesticides impairs glucose metabolism and mitochondrial function in L6 myotubes and zebrafish
Chul-Min Park, Ki-Tae Kim, Dong-Young Rhyu
Journal of Hazardous Materials.2021; 414: 125437. CrossRef
Can Environmental Pollutants Be a Factor Linking Obesity and COVID-19?
Duk-Hee Lee
Journal of Korean Medical Science.2021;[Epub] CrossRef
Letter to the Editor: Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial
Yu-Mi Lee, Duk-Hee Lee
Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(5): 849. CrossRef
Can habitual exercise really increase serum concentrations of persistent organic pollutants?
Yu-Mi Lee, Duk-Hee Lee
Environment International.2020; 140: 105615. CrossRef
Response to correspondence ENVINT_2020_552 “Can habitual exercise really increase serum concentrations of persistent organic pollutants?”
Sidsel L. Domazet, Tina K. Jensen, Anders Grøntved
Environment International.2020; 140: 105616. CrossRef

Lifesytle
Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women: Yun Kyung Jeon, Sang Soo Kim, Jong Ho Kim, Hyun Jeong Kim, Hyun Jun Kim, Jang Jun Park, Yuen Suk Cho, So Hee Joung, Ji Ryang Kim, Bo Hyun Kim, Sang Heon Song, In Joo Kim, Yong Ki Kim, Young-Bum Kim; Diabetes Metab J. 2020;44(1):103-112. Published online February 21, 2020; DOI: https://doi.org/10.4093/dmj.2018.0160

14,950 View
229 Download
28 Web of Science
25 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown. Here, we investigated whether a combined exercise can alter the circulating ApoJ level, and whether these changes are associated with metabolic indices in patients with type 2 diabetes mellitus.

Methods

Postmenopausal women with type 2 diabetes mellitus were randomly assigned into either an exercise (EXE, n=30) or control (CON, n=15) group. Participants in the EXE group were enrolled in a 12-week program consisting of a combination of aerobic and resistance exercises. At baseline, 4, 8, and 12 weeks, body composition and metabolic parameters including homeostatic model assessment of insulin resistance (HOMA-IR) and serum ApoJ levels were assessed.

Results

In the EXE group, ApoJ levels decreased 26.3% and 19.4%, relative to baseline, at 8 and 12 weeks, respectively. Between-group differences were significant at 8 and 12 weeks (P<0.05 and P<0.001, respectively). In the EXE group, 12 weeks of exercise resulted in significant decreases in body weight, percent body fat, and HOMA-IR indices. Concurrently, weight-adjusted appendicular skeletal muscle mass (ASM/wt) was increased in the EXE group compared with the CON group. Importantly, changes in the ApoJ level were significantly correlated with changes in ASM/wt.

Conclusion

Exercise training resulted in a significant decrease in the circulating ApoJ level, with changes in ApoJ associated with an improvement in some insulin resistance indices. These data suggest that circulating ApoJ may be a useful metabolic marker for assessing the effects of exercise on insulin resistance.

Citations

Citations to this article as recorded by

Treinamento físico combinado melhora componentes para síndrome metabólica em mulheres jovens: um estudo de coorte retrospectiva
Stefhany Beatriz Almeida da Silva, Vanessa Goltzman, Brenna Emmanuella Carvalho Agostinho, Franklin Fernandes Dias, Beatriz Gonçalves Barbosa da Fonsêca, Luis Ângelo Macedo Santiago
Revista de Educação Física / Journal of Physical Education.2025; 93(4): 244. CrossRef
Effect of combined aerobic exercise and resistance training on postmenopausal women with type 2 diabetes: a systematic review and meta-analysis
Vitor Engracia Valenti, André dos Santos Chagas, Peter Chedraui, Ingrid Soares de Souza, Andrey Alves Porto, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Júnior, Juliana Zangirolami-Raimundo, David M. Garner, Rodrigo Daminello Raimundo
Gynecological Endocrinology.2025;[Epub] CrossRef
Bridging systemic metabolic dysfunction and Alzheimer’s disease: the liver interface
Dan Song, Yang Li, Ling-Ling Yang, Ya-Xi Luo, Xiu-Qing Yao
Molecular Neurodegeneration.2025;[Epub] CrossRef
Associations of circulating apolipoprotein J and myostatin with sarcopenia in older adults with and without type 2 diabetes: a cross-sectional study
Inha Jung, Da-Hye Shin, Hyun Joo Cho, So Young Park, Da Young Lee, Ji Hee Yu, Nan Hee Kim, Minjin Lee, Young-Bum Kim, Ji A Seo
Frontiers in Endocrinology.2025;[Epub] CrossRef
Effects of concurrent continuous aerobic and short rest resistance exercise training on metabolic biomarkers in type 2 diabetes patients: a systematic review and meta-analysis
Friew Amare, Alemmebrat Kiflu, Aschenaki Taddese
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Effects of different exercise modes on the risk factors of arteriosclerosis in postmenopausal women: A systematic review and network meta-analysis
Jin Li, Peizhen Zhang, Yuting Yang
Journal of Human Hypertension.2025; 39(9): 601. CrossRef
Combined Effects of Exercise and Broccoli Supplementation on Metabolic and Lipoprotein Biomarkers in Adults with Type 2 Diabetes: A Randomized Controlled Trial
Maryam Delfan, Masoumeh Gharedaghi, Farzaneh Zeynali, Rawad El Hage, Anthony C. Hackney, Halil İbrahim Ceylan, Ayoub Saeidi, Ismail Laher, Nicola Luigi Bragazzi, Hassane Zouhal
Nutrients.2025; 17(17): 2735. CrossRef
Sociodemographic, Lifestyle, and Social Isolation Correlates of TyG, METS-IR, and SPISE-IR Scores in a Large Spanish Working Population
Pere Riutord-Sbert, Pedro Juan Tárraga López, Ángel Arturo López-González, Irene Coll Campayo, Carla Busquets-Cortés, José Ignacio Ramírez Manent
Medical Sciences.2025; 13(3): 171. CrossRef
Network meta-analysis of the effects of combined exercise and vitamin intervention on insulin resistance and related indicators in patients with type 2 diabetes
Fangquan Deng, Yin Ji, Haijun Kong, Yebiao Fu, Hanqiao Zhang, Junting Zhang
Frontiers in Nutrition.2025;[Epub] CrossRef
Effects of aerobic, resistance, interval, and combined training on glucose metabolism in older adults: insights into type, dose, and mechanism
Qilong Zhang, Yifan Guo, Hengyi Zhang, Weiliang Xu, Lijun Yin
Frontiers in Physiology.2025;[Epub] CrossRef
Effectiveness of multi-component exercise in individuals with type 2 diabetes: a systematic review and meta-analysis
Zhiyuan Sun, Haiqing Zeng, Hualei Liu, Mengqi Hu, Xuewen Tian, Dewei Mao, Rui Zhang
PeerJ.2025; 13: e20146. CrossRef
Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery
Kellen Cristina da Cruz Rodrigues, Minjin Lee, Yejee Lim, Jennie Young, Brendon Chung, Susan Phillips, Theodore P. Ciaraldi, Young‐Bum Kim
Clinical Endocrinology.2025;[Epub] CrossRef
The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases
Xuepeng Bian, Qian Wang, Yibing Wang, Shujie Lou
Frontiers in Molecular Neuroscience.2024;[Epub] CrossRef
A randomized controlled trial of an app-based intervention on physical activity and glycemic control in people with type 2 diabetes
Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
BMC Medicine.2024;[Epub] CrossRef
Exercise modalities for type 2 diabetes: A systematic review and network meta‐analysis of randomized trials
Liangying Hou, Qi Wang, Bei Pan, Rui Li, Yanfei Li, Juanjuan He, Tianzhu Qin, Liujiao Cao, Na Zhang, Changhao Cao, Long Ge, Kehu Yang
Diabetes/Metabolism Research and Reviews.2023;[Epub] CrossRef
Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials
Gina Wood, Emily Taylor, Vanessa Ng, Anna Murrell, Aditya Patil, Tom van der Touw, Mitch Wolden, Nick Andronicos, Neil A. Smart
Sports Medicine.2023; 53(4): 871. CrossRef
2023 update on Italian guidelines for the treatment of type 2 diabetes
Edoardo Mannucci, Riccardo Candido, Lina delle Monache, Marco Gallo, Andrea Giaccari, Maria Luisa Masini, Angela Mazzone, Gerardo Medea, Basilio Pintaudi, Giovanni Targher, Marina Trento, Giuseppe Turchetti, Valentina Lorenzoni, Matteo Monami
Acta Diabetologica.2023; 60(8): 1119. CrossRef
The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome
Seyed Amir Hosain Diba Hosaini, Morvarid Vafaee, Bahram Abedi
Hormozgan Medical Journal.2023; 27(1): 43. CrossRef
An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome: Insights for Novel Therapeutic Approaches
Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Leonardo A. C. Marques, Gabriela S. Santos, Gisele Simão, Laryssa R. Bueno, Daniele Maria-Ferreira, Marcelo N. Muscará, Elizabeth S. Fernandes
Cells.2022; 11(8): 1292. CrossRef
Effect of Yijinjing combined with elastic band exercise on muscle mass and function in middle-aged and elderly patients with prediabetes: A randomized controlled trial
Yunda Huang, Junhua Han, Qing Gu, Yanwei Cai, Jingyuan Li, Shasha Wang, Suijun Wang, Ru Wang, Xiangyun Liu
Frontiers in Medicine.2022;[Epub] CrossRef
Effect of combined aerobic and resistance exercise on blood pressure in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials
Huihui Xi, Yayu He, Yirou Niu, Xin Sui, Jun Zhang, Ruiting Zhu, Haiyan Xu, Shuang Zhang, Yang Li, Yuan Yuan, Lirong Guo
Experimental Gerontology.2021; 155: 111560. CrossRef
Effects of Augmented-Reality-Based Exercise on Muscle Parameters, Physical Performance, and Exercise Self-Efficacy for Older Adults
Sangwan Jeon, Jiyoun Kim
International Journal of Environmental Research and Public Health.2020; 17(9): 3260. CrossRef
Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity
Ji A Seo, Min-Cheol Kang, Won-Mo Yang, Won Min Hwang, Sang Soo Kim, Soo Hyun Hong, Jee-In Heo, Achana Vijyakumar, Leandro Pereira de Moura, Aykut Uner, Hu Huang, Seung Hwan Lee, Inês S. Lima, Kyong Soo Park, Min Seon Kim, Yossi Dagon, Thomas E. Willnow, V
Nature Communications.2020;[Epub] CrossRef
Impact of Skeletal Muscle Mass on Metabolic Health
Gyuri Kim, Jae Hyeon Kim
Endocrinology and Metabolism.2020; 35(1): 1. CrossRef
Habitual Combined Exercise Protects against Age-Associated Decline in Vascular Function and Lipid Profiles in Elderly Postmenopausal Women
Elizabeth J. Pekas, John Shin, Won-Mok Son, Ronald J. Headid, Song-Young Park
International Journal of Environmental Research and Public Health.2020; 17(11): 3893. CrossRef

Lifestyle
Body Fat Is Related to Sedentary Behavior and Light Physical Activity but Not to Moderate-Vigorous Physical Activity in Type 2 Diabetes Mellitus: Keun Hee An, Kyung Ah Han, Tae Seo Sohn, Ie Byung Park, Hae Jin Kim, Sung Dae Moon, Kyung Wan Min; Diabetes Metab J. 2020;44(2):316-325. Published online November 12, 2019; DOI: https://doi.org/10.4093/dmj.2019.0029

9,893 View
162 Download
14 Web of Science
17 Crossref

Abstract PDF PubReader ePub

Background

Sedentary behavior (SB) has emerged as a new risk factor for cardiovascular accidents. We investigated whether physical activity levels or SB were related to percent body fat (%BF) in type 2 diabetes mellitus (T2DM).

Methods

In this cross sectional study, we measured the duration of SB, light physical activity (LPA), moderate to vigorous physical activity (MVPA), total energy expenditure, and step counts using a wireless activity tracker (Fitbit HR; FB) for 7 days in free-living conditions, along with %BF using a bio impedance analyzer (Inbody; Biospace) in 120 smartphone users with T2DM. Subjects were divided into exercise (Exe, n=68) and non-exercise (nonExe, n=52) groups based on self-reports of whether the recommended exercises (30 min/day, 3 days/week for 3 months) were performed. SBt, LPAt, MVPAt were transformed from SB, LPA, MVPA for normally distributed variables.

Results

Participants were: female, 59.2%; age, 59.3±8.4 years; body mass index, 25.5±3.4 kg/m²; glycosylated hemoglobin (HbA1c), 7.6%±1.2%; %BF, 30.4%±7.1%. They performed SB for 15.7±3.7 hr/day, LPA for 4.4±1.7 hr/day, and MVPA for 0.9±0.8 hr/day. The %BF was related to SBt and LPAt, but not to MVPA after adjustments for age, gender, and HbA1c. VPA was significantly higher in the Exe group than in the nonExe group, but SB, LPA, and moderate physical activity were not different. Predicted %BF was 89.494 to 0.105 (age), −13.047 (gender), −0.507 (HbA1c), −7.655 (LPAt) (F[4, 64]=62.929, P<0.001), with an R² of 0.785 in multiple linear regression analysis.

Conclusion

Reduced body fat in elderly diabetic patients might be associated with reduced inactivity and increased LPA.

Citations

Citations to this article as recorded by

Associations of nonoccupational sedentary behaviors with cardiometabolic outcomes: coronary artery risk development in young adults (CARDIA)
Gabriel Zieff, Michael P Bancks, Kelley Pettee Gabriel, Bethany Barone Gibbs, Justin B Moore, Jared P Reis, Keeron Stone, Lee Stoner
Annals of Behavioral Medicine.2025;[Epub] CrossRef
The Power of Movement: Linking Physical Activity with Nutritional Health and Blood Sugar Balance in a Dalmatian Type 2 Diabetic Population
Josipa Radić, Andrej Belančić, Hana Đogaš, Marijana Vučković, Tina Đogaš, Leida Tandara, Marina Grubić, Lucija Šolić Šegvić, Ivana Novak, Mislav Radić
Nutrients.2025; 17(1): 187. CrossRef
Development and validation of a prognostic model for critically ill type 2 diabetes patients in ICU based on composite inflammatory indicators
Lin Liu, Yan-Bo Zhao, Zhuo-Ting Cheng, Ya-Hui Li, Yang Liu
Scientific Reports.2025;[Epub] CrossRef
Cardiovascular Disease Risk Factors and Arterial Health in Adults With Down Syndrome
Brantley K. Ballenger, Stanley P. Brown, Bo Fernhall, Robert W. Motl, Stamatis Agiovlasitis
Journal of Clinical Exercise Physiology.2025; 14(1): 10. CrossRef
Revolutionizing diabetes management: Artificial intelligence (AI) from assessment to advanced monitoring
Mobin Ghaderi, Kosar Chitzan-Zadeh, Milad Mokarami, Mobina Mokarami, Marzieh Shokoohi, Reza Golchin Vafa
Next Research.2025; 2(3): 100472. CrossRef
The importance of daily life activities in managing obesity in patients with type 2 diabetes mellitus: a study using physical activity records
Yushin Yamamoto, Minoru Yamada, Yusuke Terao, Akiyoshi Miyazawa, Iwao Kojima, Shu Tanaka, Kosaku Katsumata, Keigo Sato, Ryosuke Kita, Shunya Mimatsu, Naoki Tani, Keita Aida, Shunsuke Funazaki, Hodaka Yamada, Masashi Yoshida, Kazuo Hara
Diabetology International.2025; 16(4): 801. CrossRef
Explanatory variables of objectively measured 24-h movement behaviors in people with prediabetes and type 2 diabetes: A systematic review
Lotte Bogaert, Iris Willems, Patrick Calders, Eveline Dirinck, Manon Kinaupenne, Marga Decraene, Bruno Lapauw, Boyd Strumane, Margot Van Daele, Vera Verbestel, Marieke De Craemer
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(4): 102995. CrossRef
Short-Term Effects of a Mobile Health Intervention on Healthy Behaviors and Cardiometabolic Health in Sedentary Employees: A Quasi-Experimental Study (Preprint)
Yun-Ping Lin, Shu-Hua Lu, Kwo-Chen Lee, Wei-Fen Ma, Ya-Fang Ho, Wen-Chun Liao, Hui-Ting Yang, OiSaeng Hong
JMIR mHealth and uHealth.2024;[Epub] CrossRef
Association between depression, anemia and physical activity using isotemporal substitution analysis
Hee-kyoung Nam, Jungmi Park, Sung-il Cho
BMC Public Health.2023;[Epub] CrossRef
The Impact of Wearable Technologies in Health Research: Scoping Review
Sophie Huhn, Miriam Axt, Hanns-Christian Gunga, Martina Anna Maggioni, Stephen Munga, David Obor, Ali Sié, Valentin Boudo, Aditi Bunker, Rainer Sauerborn, Till Bärnighausen, Sandra Barteit
JMIR mHealth and uHealth.2022; 10(1): e34384. CrossRef
The Correlation of Prediabetes and Type 2 Diabetes With Adiposity in Adults
Juan Sun, Zhen Liu, Zimu Zhang, Ziyang Zeng, Weiming Kang
Frontiers in Nutrition.2022;[Epub] CrossRef
The Physical Activity Assessment of Adults With Type 2 Diabetes Using Accelerometer-Based Cut Points: Scoping Review
Ioana A Moldovan, Alexa Bragg, Anna S Nidhiry, Barbara A De La Cruz, Suzanne E Mitchell
Interactive Journal of Medical Research.2022; 11(2): e34433. CrossRef
Effects of 4 Weeks of a Technique-Specific Protocol with High-Intensity Intervals on General and Specific Physical Fitness in Taekwondo Athletes: An Inter-Individual Analysis
Alex Ojeda-Aravena, Tomás Herrera-Valenzuela, Pablo Valdés-Badilla, Jorge Cancino-López, José Zapata-Bastias, José Manuel García-García
International Journal of Environmental Research and Public Health.2021; 18(7): 3643. CrossRef
Inter-Individual Variability of a High-Intensity Interval Training With Specific Techniques vs. Repeated Sprints Program in Sport-Related Fitness of Taekwondo Athletes
Alex Ojeda-Aravena, Tomás Herrera-Valenzuela, Pablo Valdés-Badilla, Jorge Cancino-López, José Zapata-Bastias, José Manuel García-García
Frontiers in Physiology.2021;[Epub] CrossRef
EFFECT OF SPORTS MEDICINE ON REDUCING BODY FAT PERCENTAGE AND LEAN BODY MASS
Chunyan Fan
Revista Brasileira de Medicina do Esporte.2021; 27(7): 714. CrossRef
Validation of the effectiveness of a digital integrated healthcare platform utilizing an AI-based dietary management solution and a real-time continuous glucose monitoring system for diabetes management: a randomized controlled trial
Sung Woon Park, Gyuri Kim, You-Cheol Hwang, Woo Je Lee, Hyunjin Park, Jae Hyeon Kim
BMC Medical Informatics and Decision Making.2020;[Epub] CrossRef
Brain activity during a working memory task in different postures: an EEG study
Ju-Yeon Jung, Hwi-Young Cho, Chang-Ki Kang
Ergonomics.2020; 63(11): 1359. CrossRef

Short Communication

Clinical Diabetes & Therapeutics
Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients: Ilenia Cirilli, Sonia Silvestri, Fabio Marcheggiani, Fabiola Olivieri, Roberta Galeazzi, Roberto Antonicelli, Rina Recchioni, Fiorella Marcheselli, Tiziana Bacchetti, Luca Tiano, Patrick Orlando; Diabetes Metab J. 2019;43(6):893-897. Published online June 27, 2019; DOI: https://doi.org/10.4093/dmj.2018.0254

7,141 View
59 Download
14 Web of Science
14 Crossref

Abstract PDF PubReader ePub

Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.

Citations

Citations to this article as recorded by

The comparison of miRNA expression levels in Type 2 diabetes and diabetic peripheral neuropathy patients
Aleyna Ayaz, Sibel Kuras, Bekir Erdogan, Hanife Serife Aktas, Mahmud Esad Pence, Halime Hanim Pence
Clinical Biochemistry.2025; 138: 110946. CrossRef
Effectiveness of Wearable Technologies in Supporting Physical Activity and Metabolic Health in Adults with Type 2 Diabetes: A Systematic–Narrative Hybrid Review
Alessandra Laffi, Michela Persiani, Alessandro Piras, Andrea Meoni, Milena Raffi
Healthcare.2025; 13(19): 2422. CrossRef
Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes
Aref Basereh, Karen Khoramipour, Najmeh Hosseini, Mahdieh HajHosseini, Adeleh Khodabakhshi, Ladan Amirkhosravi, Kayvan Khoramipour
Scientific Reports.2025;[Epub] CrossRef
Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
Dharmsheel Shrivastav, Desh Deepak Singh
World Journal of Clinical Cases.2024; 12(3): 525. CrossRef
Is It Possible to Train the Endothelium?—A Narrative Literature Review
Karolina Biernat, Natalia Kuciel, Justyna Mazurek, Katarzyna Hap
Life.2024; 14(5): 616. CrossRef
The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases—A Systematic Review
Moomna Afzal, Francesca Greco, Federico Quinzi, Francesca Scionti, Samantha Maurotti, Tiziana Montalcini, Annamaria Mancini, Pasqualina Buono, Gian Pietro Emerenziani
International Journal of Molecular Sciences.2024; 25(13): 6813. CrossRef
Dose-Response Relationship Between Physical Activity and the Morbidity and Mortality of Cardiovascular Disease Among Individuals With Diabetes: Meta-Analysis of Prospective Cohort Studies
Yang Chen, Xingsheng Jin, Guochong Chen, Ru Wang, Haili Tian
JMIR Public Health and Surveillance.2024; 10: e54318. CrossRef
Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases
Waleska Dornas, Maisa Silva
Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(12): 2611. CrossRef
Research Landscape of Diabetes mHealth Technologies
Pedro F. Castillo-Valdez, Marisela Rodriguez-Salvador, Yuh-Shan Ho
Foresight and STI Governance.2024; 18(1): 19. CrossRef
Effects of Seven Weeks of Combined Physical Training on High-Density Lipoprotein Functionality in Overweight/Obese Subjects
Tiziana Bacchetti, Camilla Morresi, Gianna Ferretti, Anders Larsson, Torbjörn Åkerfeldt, Michael Svensson
Metabolites.2023; 13(10): 1068. CrossRef
Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases
Juan Gao, Xue Pan, Guoping Li, Emeli Chatterjee, Junjie Xiao
Journal of Cardiovascular Translational Research.2022; 15(3): 604. CrossRef
Effects of Exercise Training on the Paracrine Function of Circulating Angiogenic Cells
William S. Evans, Ryan M. Sapp, Katherine I. Kim, James M. Heilman, James Hagberg, Steven J. Prior
International Journal of Sports Medicine.2021; 42(12): 1047. CrossRef
Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes
Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Aneta Balcerczyk, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska
International Journal of Molecular Sciences.2021; 22(13): 6964. CrossRef
The Potential Role of MicroRNA in Diabetic Cardiomyopathy
Jin Hwa Kim
Diabetes & Metabolism Journal.2020; 44(1): 54. CrossRef

Original Articles

Clinical Diabetes & Therapeutics
Effectiveness of Exercise Intervention in Reducing Body Weight and Glycosylated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus in Korea: A Systematic Review and Meta-Analysis: Ji-Eun Jang, Yongin Cho, Byung Wan Lee, Ein-Soon Shin, Sun Hee Lee; Diabetes Metab J. 2019;43(3):302-318. Published online November 19, 2018; DOI: https://doi.org/10.4093/dmj.2018.0062

11,434 View
138 Download
16 Web of Science
19 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

This study aimed to assess the effectiveness of exercise intervention in reducing body weight and glycosylated hemoglobin (HbA1c) level in patients with type 2 diabetes mellitus (T2DM) in Korea.

Methods

Cochrane, PubMed, Embase, KoreaMed, KMbase, NDSL, KCI, RISS, and DBpia databases were used to search randomized controlled trials and controlled clinical trials that compared exercise with non-exercise intervention among patients with non-insulin-treated T2DM in Korea. The effectiveness of exercise intervention was estimated by the mean difference in body weight changes and HbA1c level. Weighted mean difference (WMD) with its corresponding 95% confidence interval (CI) was used as the effect size. The pooled mean differences of outcomes were calculated using a random-effects model.

Results

We identified 7,692 studies through literature search and selected 23 articles (723 participants). Compared with the control group, exercise intervention (17 studies) was associated with a significant decline in HbA1c level (WMD, −0.58%; 95% CI, −0.89 to −0.27; I²=73%). Although no significant effectiveness on body weight was observed, eight aerobic training studies showed a significant reduction in body weight (WMD, −2.25 kg; 95% CI, −4.36 to −0.13; I²=17%) in the subgroup analysis.

Conclusion

Exercise significantly improves glycemic control; however, it does not significantly reduce body weight. Aerobic training can be beneficial for patients with non-insulin-treated T2DM in Korea.

Citations

Citations to this article as recorded by

A Feasibility Study of a Web Application Intervention for Persons With Uncontrolled Diabetes
Atchara Meenasantirak, Chalee Siripitakchai, Natthawut Suriya
Health Promotion Journal of Australia.2025;[Epub] CrossRef
Surface electromyography for characterizing neuromuscular changes in diabetic peripheral neuropathy
I. Junquera-Godoy, J.L. Martinez-De-Juan, G. González Lorente, J.M. Carot-Sierra, J. Gomis-Tena, J. Saiz, R. López Mateu, G.C. Mas Penalva, S.Garcia Blasco, E. Boix Carreño, E. Soler Climent, G. Prats-Boluda
Journal of Electromyography and Kinesiology.2025; 82: 102991. CrossRef
2025 Clinical Practice Guidelines for Diabetes Management in Korea: Recommendation of the Korean Diabetes Association
Shinae Kang, Seon Mee Kang, Jong Han Choi, Seung-Hyun Ko, Bo Kyung Koo, Hyuk-Sang Kwon, Mi Kyung Kim, Sang Yong Kim, Soo-Kyung Kim, Young-eun Kim, Eun Sook Kim, Jae Hyeon Kim, Chong Hwa Kim, Ji Min Kim, Hae Jin Kim, Min Kyong Moon, Sun Joon Moon, Jun Sung
Diabetes & Metabolism Journal.2025; 49(4): 582. CrossRef
Lifestyle Management of Hypertension and Type 2 Diabetes
JungHwan Kim
Korean Journal of Family Practice.2025; 15(3): 120. CrossRef
Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial
Emily R. Cox, Trishan Gajanand, Shelley E. Keating, Matthew D. Hordern, Nicola W. Burton, Daniel J. Green, Joyce S. Ramos, Maximiano V. Ramos, Robert G. Fassett, Stephen V. Cox, Jeff S. Coombes, Tom G. Bailey
European Journal of Applied Physiology.2024; 124(9): 2819. CrossRef
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef
Exercise as a Therapeutic Intervention for Chronic Disease Management: A Comprehensive Review
Maryam Fairag, Saif A Alzahrani, Naif Alshehri, Arjwan O Alamoudi, Yazeed Alkheriji, Omar A Alzahrani, Abdulrahman M Alomari, Yahya A Alzahrani, Shahad Mohammed Alghamdi, Amer Fayraq
Cureus.2024;[Epub] CrossRef
The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis
Georgia Papagianni, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Constantinos Antonopoulos, Dimitrios Tachmatzidis, Triantafyllos Didangelos, Vaia Lambadiari, Nikolaos P.E. Kadoglou
Cytokine.2023; 164: 156157. CrossRef
Glucose Control in Korean Patients with Type 2 Diabetes Mellitus according to Body Mass Index
Ye-lim Shin, Heesoh Yoo, Joo Young Hong, Jooeun Kim, Kyung-do Han, Kyu-Na Lee, Yang-Hyun Kim
Journal of Obesity & Metabolic Syndrome.2023; 32(1): 55. CrossRef
Exercise therapy for diabetes mellitus
Chaiho Jeong, Tae-Seo Sohn
Journal of the Korean Medical Association.2023; 66(7): 427. CrossRef
Effects of an evidence‐based nursing intervention on prevention of anxiety and depression in the postpartum period
Jun Meng, Junying Du, Xiaoli Diao, Yingxia Zou
Stress and Health.2022; 38(3): 435. CrossRef
Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
International Journal of Obesity.2021; 45(5): 982. CrossRef
Development and validation of the type 2 diabetes mellitus 10-year risk score prediction models from survey data
Gregor Stiglic, Fei Wang, Aziz Sheikh, Leona Cilar
Primary Care Diabetes.2021; 15(4): 699. CrossRef
Pioglitazone for NAFLD Patients With Prediabetes or Type 2 Diabetes Mellitus: A Meta-Analysis
Jingxuan Lian, Jianfang Fu
Frontiers in Endocrinology.2021;[Epub] CrossRef
Exercise Training: The Holistic Approach in Cardiovascular Prevention
Francesco Giallauria, Teresa Strisciuglio, Gianluigi Cuomo, Anna Di Lorenzo, Andrea D’Angelo, Mario Volpicelli, Raffaele Izzo, Maria Virginia Manzi, Emanuele Barbato, Carmine Morisco
High Blood Pressure & Cardiovascular Prevention.2021; 28(6): 561. CrossRef
Effect of chronic High Intensity Interval Training on glycosylated haemoglobin in people with type 2 diabetes: a meta-analysis
María Cristina Arrieta-Leandro, Jessenia Hernández-Elizondo, Judith Jiménez-Díaz
Human Movement.2021; 24(1): 32. CrossRef
Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee
Diabetes & Metabolism Journal.2020; 44(3): 382. CrossRef
Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
Kyung-Soo Kim, Byung-Wan Lee
Clinical and Molecular Hepatology.2020; 26(4): 430. CrossRef
Factors Influencing Glycemic Control among Type 2 Diabetes Mellitus Patients: The Sixth Korea National Health and Nutrition Examination Survey (2013~2015)
Mee Ock Gu
Korean Journal of Adult Nursing.2019; 31(3): 235. CrossRef

Obesity and Metabolic Syndrome
Beneficial Effects of Aerobic Exercise Training Combined with Rosiglitazone on Glucose Metabolism in Otsuka Long Evans Tokushima Fatty Rats: Shan-Ji Piao, So Hun Kim, Young Ju Suh, Seong-Bin Hong, Seong Hee Ahn, Da Hae Seo, In-Sun Park, Moonsuk Nam; Diabetes Metab J. 2017;41(6):474-485. Published online November 15, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.6.474

6,668 View
42 Download
4 Web of Science
3 Crossref

Abstract PDF PubReader ePub

Background

Regular aerobic exercise is essential for the prevention and management of type 2 diabetes mellitus and may be particularly beneficial for those treated with thiazolidinediones, since it may prevent associated weight gain. This study aimed to evaluate the effect of combined exercise and rosiglitazone treatment on body composition and glucose metabolism in obese diabetes-prone animals.

Methods

We analyzed metabolic parameters, body composition, and islet profiles in Otsuka Long Evans Tokushima Fatty rats after 28 weeks of aerobic exercise, rosiglitazone treatment, and combined exercise and rosiglitazone treatment.

Results

Combined exercise with rosiglitazone showed significantly less increase in weight and epididymal fat compared to rosiglitazone treatment. Aerobic exercise alone and combined rosiglitazone and exercise treatment led to similar retention of lean body mass. All experimental groups showed a decrease in fasting glucose. However, the combined exercise and rosiglitazone therapy group showed prominent improvement in glucose tolerance compared to the other groups. Rescue of islet destruction was observed in all experimental groups, but was most prominent in the combined therapy group.

Conclusion

Regular aerobic exercise combined with rosiglitazone treatment can compensate for the adverse effect of rosiglitazone treatment and has benefit for islet preservation.

Citations

Citations to this article as recorded by

A Review of Animal Models for Studying Bone Health in Type-2 Diabetes Mellitus (T2DM) and Obesity
Saiful Iqbal Norazman, Anis Syauqina Mohd Zaffarin, Ahmad Nazrun Shuid, Haniza Hassan, Ima Nirwana Soleiman, Wong Sok Kuan, Ekram Alias
International Journal of Molecular Sciences.2024; 25(17): 9399. CrossRef
Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review
Shuang Zhang, Yaru Wei, Chunxiao Wang
International Journal of Environmental Research and Public Health.2022; 19(12): 7229. CrossRef
Molecular mechanisms by which aerobic exercise induces insulin sensitivity
Habib Yaribeygi, Stephen L. Atkin, Luis E. Simental‐Mendía, Amirhossein Sahebkar
Journal of Cellular Physiology.2019; 234(8): 12385. CrossRef

Others
The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women: Zeinab AminiLari, Mohammad Fararouei, Sasan Amanat, Ehsan Sinaei, Safa Dianatinasab, Mahmood AminiLari, Nima Daneshi, Mostafa Dianatinasab; Diabetes Metab J. 2017;41(3):205-212. Published online May 18, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.3.205

10,279 View
149 Download
69 Web of Science
70 Crossref

Abstract PDF PubReader ePub

Background

Recent studies have shown that omentin-1 derived from adipokines can affect physiological regulations and some metabolic dis-eases such as type 2 diabetes mellitus (T2DM).

Methods

The purpose of this study was to examine the impact of 12 weeks of aerobic (cycle ergometer), resistance, and combined exercises on omentin-1 level, glucose and insulin resistance indices in overweight middle age women with T2DM. In this study, 60 overweight middle age diabetic women were selected using simple random sampling and they were assigned to three groups of aerobic exercise (n=12), resistant exercise (n=12) and combined exercise (n=13), and one control group (n=15). Exercises were done in a three times per week sessions for a total of 12 weeks. Blood samples were collected before each exercise session and 24 hours after of the last session.

Results

Present study showed that fasting blood sugar decreased significantly in all intervention groups, while homeostasis model assessment of insulin resistance (HOMA-IR) decreased only in the aerobic and combined exercises groups. Furthermore, there was a significant increase in the omentin-1 level only in the combined exercise group.

Conclusion

Compared to aerobic and resistance exercises, 12 weeks of combined exercise was more efficient in improving HOMA-IR and increasing serum omentin-1 among women with T2DM.

Citations

Citations to this article as recorded by

Impact of exercise sequence in concurrent training on insulin resistance, glycemic control, and blood pressure in Type 2 diabetes
Friew Amare, Alemmebrat Kiflu, Aschenaki Taddese, Ozeas de Lima Lins-Filho
PLOS One.2026; 21(1): e0340587. CrossRef
Effects of exercise training on oxidative phosphorylation-related genes in a diabetic heart via microarray analysis
Iqbal Ali Shah, Shahid Ishaq, Shin-Da Lee, Bor-Tsang Wu
BMC Cardiovascular Disorders.2026;[Epub] CrossRef
Optimal strategies for exercise intervention in older people diabetic patients: The impacts of intensity, form, and frequency on glycemic control
Xueru Yan, Yujuan Lu, Haoda Zhang, Chen Zhu, Lan Tian, Jishuai Chen, Enpeng He, Yingying Li
Archives of Gerontology and Geriatrics.2025; 128: 105621. CrossRef
The Function of Myostatin in Ameliorating Bone Metabolism Abnormalities in Individuals with Type 2 Diabetes Mellitus by Exercise
Chenghao Zhong, Xinyu Zeng, Xiaoyan Yi, Yuxin Yang, Jianbo Hu, Rongbin Yin, Xianghe Chen
Current Issues in Molecular Biology.2025; 47(3): 158. CrossRef
Exerkine-mediated organ interactions: A new interpretation of exercise on cardiovascular function improvement
Renhan Liu, Yue Xi, Xinyan Duan, Yifei Zhao, Zhenjun Tian
Life Sciences.2025; 371: 123628. CrossRef
Mechanisms of endurance and resistance exercise in type 2 diabetes mellitus: A Narrative review
Xinwen Zhao, Fengwei Huang, Yidi Sun, Lisha Li
Biochemical and Biophysical Research Communications.2025; 761: 151731. CrossRef
The Effects of Concurrent Training Versus Aerobic or Resistance Training Alone on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis
Mousa Khalafi, Shokoufeh Kheradmand, Aref Habibi Maleki, Michael E. Symonds, Sara K. Rosenkranz, Alexios Batrakoulis
Healthcare.2025; 13(7): 776. CrossRef
Effects of Commuter Cycling on Physical Activity, Cardiometabolic Health and Body Composition
B. James Novis, Elaine A. Hargreaves, Tim Jowett, Nancy J. Rehrer
European Journal of Sport Science.2025;[Epub] CrossRef
Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search
Tim Havers, Steffen Held, Martin Schönfelder, Stephan Geisler, Henning Wackerhage
Sports Medicine.2025; 55(8): 1867. CrossRef
Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis
Li Cui, Donglei Lu, Sijie Tan, Liquan Cao
Frontiers in Endocrinology.2025;[Epub] CrossRef
Effects of concurrent continuous aerobic and short rest resistance exercise training on metabolic biomarkers in type 2 diabetes patients: a systematic review and meta-analysis
Friew Amare, Alemmebrat Kiflu, Aschenaki Taddese
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
The effects of resistance training on glycemic control, cardiometabolic health, and body composition in middle-aged and older women with type 2 diabetes and overweight or obesity: A systematic review and meta-analysis
Ruojiang Liu, Xiaofeng Shi, Xiang Zhang
Maturitas.2025; 201: 108691. CrossRef
Genetica e attività fisica: dalla prestazione atletica alla clinica
Antonio IMPERATORE, Cristina MENNITTI, Giulia DE FONZO, Raffaele AMITRANO, Mariella CALVANESE, Alessandro GENTILE, Fabiana DI FUSCO, Victoria DI MARTINO, Ludovica PRETE, Fernanda IAFUSCO, Mattia DIGNO, Paola BORRELLI, Giulia FRISSO, Nadia TINTO, Barbara L
Biochimica Clinica.2025;[Epub] CrossRef
Toward a Multi-Trait Genetic Panel Targeting Training, Rehabilitation, and Chronic Disease Prevention: A Narrative Review
Antonio Imperatore, Cristina Mennitti, Giulia De Fonzo, Raffaele Amitrano, Alessandro Gentile, Mariella Calvanese, Fernanda Iafusco, Serena Coppola, Mattia Digno, Paola Borrelli, Barbara Lombardo, Giulia Frisso, Roberto Berni Canani, Nadia Tinto, Valeria
Genes.2025; 16(11): 1309. CrossRef
Network meta-analysis of the effects of combined exercise and vitamin intervention on insulin resistance and related indicators in patients with type 2 diabetes
Fangquan Deng, Yin Ji, Haijun Kong, Yebiao Fu, Hanqiao Zhang, Junting Zhang
Frontiers in Nutrition.2025;[Epub] CrossRef
Omentin-1 and diabetes: more evidence but far from enough
Jing Xu, Min Li, Xinli Jiang, Yuling Wang, Huijie Ma, Yaru Zhou, Meimei Tian, Yan Liu
Archives of Physiology and Biochemistry.2024; 130(6): 599. CrossRef
Effect of Exercise Training on Some Anti-Inflammatory Adipokines, High Sensitivity C-Reactive Protein, and Clinical Outcomes in Sedentary Adults With Metabolic Syndrome
Kelian Gao, Zhanguo Su, Junyan Meng, Yuzhong Yao, LiGuang Li, Yiping Su, Gholam Rasul Mohammad Rahimi
Biological Research For Nursing.2024; 26(1): 125. CrossRef
The effect of exercise training on serum Omentin-1 levels, glycemic control and body composition in adults population: a systematic review and meta-analysis of randomized controlled trials
Ali Asgari, Arghavan Niyazi, Ali Nejatian Hoseinpour, Shayan Setayesh, Rokhsare Fazolahzade Mousavi, Gholam Rasul Mohammad Rahimi
International Journal of Diabetes in Developing Countries.2024; 44(3): 437. CrossRef
Enhancing cardiometabolic health: unveiling the synergistic effects of high-intensity interval training with spirulina supplementation on selected adipokines, insulin resistance, and anthropometric indices in obese males
Maryam Delfan, Ayoub Saeidi, Rashmi Supriya, Kurt A Escobar, Ismail Laher, Katie M. Heinrich, Katja Weiss, Beat Knechtle, Hassane Zouhal
Nutrition & Metabolism.2024;[Epub] CrossRef
Mitochondria‐associated membranes contribution to exercise‐mediated alleviation of hepatic insulin resistance: Contrasting high‐intensity interval training with moderate‐intensity continuous training in a high‐fat diet mouse model
Xi Li, Jun Yang Yang, Wen Zhi Hu, YuXin Ruan, Hong Ying Chen, Qiang Zhang, Zhe Zhang, Zhe Shu Ding
Journal of Diabetes.2024;[Epub] CrossRef
The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Yuwen Wan, Zhanguo Su
Biological Research For Nursing.2024; 26(4): 597. CrossRef
Impact of resistance exercise program on muscle strength, cardiopulmonary function and glycolipid metabolism of bedridden population aged 80 years and above: A randomized controlled trial
Yingjie Wang, Xiaopeng Huo, Xiaojing Wang, Hongwei Zhu, Xiaoxing Lai, Tong Yu
Medicine.2024; 103(24): e38412. CrossRef
Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Yan Sun, Mingwei Sun, Xia Zeng, Liojuan Xiang Je, Zhannguo Su Guo
Acta Diabetologica.2024; 62(1): 11. CrossRef
Aerobic Exercise and Weight Loss in Adults
Ahmad Jayedi, Sepideh Soltani, Alireza Emadi, Mahdieh-Sadat Zargar, Ali Najafi
JAMA Network Open.2024; 7(12): e2452185. CrossRef
Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Antonio García-Hermoso, Robinson Ramírez-Vélez, Javier Díez, Arantxa González, Mikel Izquierdo
Journal of Sport and Health Science.2023; 12(2): 147. CrossRef
Physical Activity Types, Physical Activity Levels and Risk of Diabetes in General Adults: The NHANES 2007–2018
Chunnan Li, Shaomei Shang, Wannian Liang
International Journal of Environmental Research and Public Health.2023; 20(2): 1398. CrossRef
Intensity Differences of Resistance Training for Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis
Tenglong Fan, Man-Hsu Lin, Kijin Kim
Healthcare.2023; 11(3): 440. CrossRef
Chronic Resistance Training Effects on Serum Adipokines in Type 2 Diabetes Mellitus: A Systematic Review
Pablo Jiménez-Martínez, Rodrigo Ramirez-Campillo, Carlos Alix-Fages, Javier Gene-Morales, Amador García-Ramos, Juan C. Colado
Healthcare.2023; 11(4): 594. CrossRef
The impact of high intensity interval training on serum omentin-1 levels, lipid profile, and insulin resistance in obese men with type 2 diabetes mellitus
Ahmed S. Ahmed, Marwan S. Ahmed
Isokinetics and Exercise Science.2023; 31(3): 221. CrossRef
Long‐term effects of different exercise training modes on cytokines and adipokines in individuals with overweight/obesity and cardiometabolic diseases: A systematic review, meta‐analysis, and meta‐regression of randomized controlled trials
Sebastian Del Rosso, María Lucía Baraquet, Adrián Barale, María Daniela Defagó, Fernando Tortosa, Nilda Raquel Perovic, Maria Pilar Aoki
Obesity Reviews.2023;[Epub] CrossRef
The Effects of Eight Weeks of Circuit Resistance Training on Serum METRNL Levels and Insulin Resistance in Individuals with Type 2 Diabetes
Seyed Morteza Tayebi, Milad Golmohammadi, Rasoul Eslami, Nadia Shakiba, Pablo B. Costa
Journal of Diabetes & Metabolic Disorders.2023; 22(2): 1151. CrossRef
The Effect of Eight Weeks of Concurrent Training on Serum Levels of Paraxonase-1, Irisin, Lipid Profile, and Insulin Resistance in Men With Metabolic Syndrome
Seyed Amir Hosain Diba Hosaini, Morvarid Vafaee, Bahram Abedi
Hormozgan Medical Journal.2023; 27(1): 43. CrossRef
Astaxanthin Supplementation Augments the Benefits of CrossFit Workouts on Semaphorin 3C and Other Adipokines in Males with Obesity
Rashmi Supriya, Sevda Rahbari Shishvan, Movahed Kefayati, Hossein Abednatanzi, Omid Razi, Reza Bagheri, Kurt A. Escobar, Zhaleh Pashaei, Ayoub Saeidi, Shahnaz Shahrbanian, Sovan Bagchi, Pallav Sengupta, Maisa Hamed Al Kiyumi, Katie M. Heinrich, Hassane Zo
Nutrients.2023; 15(22): 4803. CrossRef
Joint Association of Relative Grip Strength and Resting Heart Rate with the Risk of Developing Diabetes in Middle-Aged Adults
DooYong Park, YeonSoo Kim, Eunkyung Kim
The Korean Journal of Sports Medicine.2023; 41(4): 216. CrossRef
High-intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity
Sirvan Atashak, Stephen R. Stannard, Ali Daraei, Mohammad Soltani, Ayoub Saeidi, Fatah Moradi, Ismail Laher, Anthony C. Hackney, Hassane Zouhal
International Journal of Sports Medicine.2022; 43(04): 328. CrossRef
Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
BMJ Open Diabetes Research & Care.2022; 10(2): e002595. CrossRef
Exercise and Type II Diabetes Mellitus: A Brief Guide for Exercise Professionals
Alexios Batrakoulis, Athanasios Z. Jamurtas, Ioannis G. Fatouros
Strength & Conditioning Journal.2022; 44(6): 64. CrossRef
Effects of High-Intensity Interval Training on Selected Adipokines and Cardiometabolic Risk Markers in Normal-Weight and Overweight/Obese Young Males—A Pre-Post Test Trial
Nejmeddine Ouerghi, Mohamed Kacem Ben Fradj, Martine Duclos, Anissa Bouassida, Moncef Feki, Katja Weiss, Beat Knechtle
Biology.2022; 11(6): 853. CrossRef
Comparison of the Effect of Endurance, Strength and Endurance-Strength Training on Glucose and Insulin Homeostasis and the Lipid Profile of Overweight and Obese Subjects: A Systematic Review and Meta-Analysis
Małgorzata Jamka, Aleksandra Makarewicz-Bukowska, Kamila Bokayeva, Angelika Śmidowicz, Jakub Geltz, Marta Kokot, Nina Kaczmarek, Agnieszka Żok, Victoria Kononets, Judyta Cielecka-Piontek, Edyta Mądry, Jarosław Walkowiak
International Journal of Environmental Research and Public Health.2022; 19(22): 14928. CrossRef
The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review
Ayoub Saeidi, Marjan Mosalman Haghighi, Sarkawt Kolahdouzi, Ali Daraei, Abderraouf Ben Abderrahmane, M. Faadiel Essop, Ismail Laher, Anthony C. Hackney, Hassane Zouhal
Obesity Reviews.2021;[Epub] CrossRef
The effect of combined resistance aerobic exercise training on concentrations of asprosin and complement C1q tumor necrosis factor-related protein-1 in men with type 2 diabetes
Mehdi Zarei, Javad Nakhzari Khodakheyr, Amin Rashidlamir, Amir Montazeri
Sport Sciences for Health.2021; 17(4): 863. CrossRef
Relationships between serum omentin-1 concentration, body composition and physical activity levels in older women
Shuo Li, Jingjing Xue, Ping Hong
Medicine.2021; 100(10): e25020. CrossRef
Markers of branched-chain amino acid catabolism are not affected by exercise training in pregnant women with obesity
Brittany R. Allman, Beverly J. Spray, Kelly E. Mercer, Aline Andres, Elisabet Børsheim
Journal of Applied Physiology.2021; 130(3): 651. CrossRef
Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications
Hassane Zouhal, Navabeh Zare-kookandeh, Marjan Mosalman Haghighi, Ali Daraei, Maysa de Sousa, Mohammad Soltani, Abderraouf Ben Abderrahman, Jed M. Tijani, Anthony C. Hackney, Ismail Laher, Ayoub Saeidi
Reviews in Endocrine and Metabolic Disorders.2021; 22(4): 987. CrossRef
Effects of Aerobic Exercise on Fasting Blood Glucose and Blood Pressure Levels of Diabetic-Hypertensive Clients at a Diabetes Clinicin Accra, Ghana
Edmund Lotsu, Samuel Kwakye, Tawagidu Mohammed, Bridgette Opoku, Jonathan Quartey, Henry Lawson
Journal of Preventive and Rehabilitative Medicine.2021; 3(2): 75. CrossRef
The Effects of Different Exercise Modalities in the Treatment of Cardiometabolic Risk Factors in Obese Adolescents with Sedentary Behavior—A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Daxin Li, Ping Chen
Children.2021; 8(11): 1062. CrossRef
Effectiveness of combined exercise in people with type 2 diabetes and concurrent overweight/obesity: a systematic review and meta-analysis
Xiaoyan Zhao, Qianyu He, Yongmei Zeng, Li Cheng
BMJ Open.2021; 11(10): e046252. CrossRef
Effects of aerobic, resistance, and combined exercise on metabolic syndrome parameters and cardiovascular risk factors: a systematic review and network meta-analysis
Minyu Liang, Yichao Pan, Tong Zhong, Yingchun Zeng, Andy S.K. Cheng
Reviews in Cardiovascular Medicine.2021;[Epub] CrossRef
Latihan Senam dapat Menurunkan Kadar Glukosa Darah Pada Penderita Diabetes Melitus Tipe II

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan.2021;[Epub] CrossRef
The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial
Aria Dianatinasab, Roghayeh Koroni, Mehrdad Bahramian, Zahra Bagheri-Hosseinabadi, Mojtaba Vaismoradi, Mohammad Fararouei, Sasan Amanat
Journal of Exercise Science & Fitness.2020; 18(3): 168. CrossRef
The association between serum omentin level and bodyweight: A systematic review and meta-analysis of observational studies
Arman Arab, Seyedeh Parisa Moosavian, Amir Hadi, Elham Karimi, Maryam Nasirian
Clinical Nutrition ESPEN.2020; 39: 22. CrossRef
Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes

Addisu Dabi Wake
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 2909. CrossRef
Role of swimming on muscle PGC-1α, FNDC5 mRNA, and assessment of serum omentin, adropin, and irisin in high carbohydrate high fat (HCHF) diet induced obesity in rats
Ehsan Badawy, Nabila A. El-laithy, Safaa M. Morsy, Magdi N. Ashour, Tahany R. Elias, Mahmoud M. Masoud, Omnia Aly
Egyptian Journal of Medical Human Genetics.2020;[Epub] CrossRef
A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR
Sasan Amanat, Ehsan Sinaei, Mohammad Panji, Reza MohammadporHodki, Zahra Bagheri-Hosseinabadi, Hadis Asadimehr, Mohammad Fararouei, Aria Dianatinasab
Frontiers in Physiology.2020;[Epub] CrossRef
The Impact of Aging on Adipose Function and Adipokine Synthesis
Peter Mancuso, Benjamin Bouchard
Frontiers in Endocrinology.2019;[Epub] CrossRef
Omentin-1 in diabetes mellitus: A systematic review and meta-analysis
Xiongfeng Pan, Atipatsa C. Kaminga, Shi Wu Wen, Kwabena Acheampong, Aizhong Liu, Omid Beiki
PLOS ONE.2019; 14(12): e0226292. CrossRef
Physical Exercise and Neuroinflammation in Major Depressive Disorder
Zuleide M. Ignácio, Renato S. da Silva, Marcos E. Plissari, João Quevedo, Gislaine Z. Réus
Molecular Neurobiology.2019; 56(12): 8323. CrossRef
Effects of Eight Weeks of High Intensity Functional Training on Glucose Control and Body Composition among Overweight and Obese Adults
Yuri Feito, Pratik Patel, Andrea Sal Redondo, Katie M. Heinrich
Sports.2019; 7(2): 51. CrossRef
Exercise and Omentin: Their Role in the Crosstalk Between Muscle and Adipose Tissues in Type 2 Diabetes Mellitus Rat Models
Cynthia Aparecida de Castro, Karina Ana da Silva, Marina Campos Rocha, Marcela Sene-Fiorese, Keico Okino Nonaka, Iran Malavazi, Fernanda de Freitas Anibal, Ana Cláudia Garcia de Oliveira Duarte
Frontiers in Physiology.2019;[Epub] CrossRef
Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
International Journal of Environmental Research and Public Health.2019; 16(1): 140. CrossRef
Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics
Eric Francelino Andrade, Víviam de Oliveira Silva, Débora Ribeiro Orlando, Luciano José Pereira
Current Diabetes Reviews.2019; 15(2): 105. CrossRef
Effects of 12 weeks of high intensity circuit training on abdominal fat, physical fitness, blood lipids, and insulin resistance in middle-aged obese women
Won-Beom Park, Hyun-Seok Cho, Man-Gyoon Lee
Korean Journal of Sport Science.2019; : 236. CrossRef
The effect of a 12-week combinational exercise program on CD4 count and mental health among HIV infected women: A randomized control trial
Mostafa Dianatinasab, Mohammad Fararouei, Valiollah Padehban, Aria Dianatinasab, Yousef Alimohamadi, Shohreh Beheshti, Zeinab AminiLari, Mahmood AminiLari
Journal of Exercise Science & Fitness.2018; 16(1): 21. CrossRef
Green tea consumption reduces apelin and orexin-A in overweight and obese women with different training modalities
Rahman Soori, Azadeh Safei, Parisa Pournemati, Amine Ghram
Sport Sciences for Health.2018; 14(2): 421. CrossRef
Lifestyle interventions for improving health and health behaviours in women with type 2 diabetes: A systematic review of the literature 2011–2017
Charrlotte Seib, Joy Parkinson, Nicole McDonald, Haruka Fujihira, Stephanie Zietek, Debra Anderson
Maturitas.2018; 111: 1. CrossRef
Association of Self-Care Behaviors and Quality of Life among Patients with Type 2 Diabetes Mellitus: Chaldoran County, Iran
Towhid Babazadeh, Mostafa Dianatinasab, Amin Daemi, Hossein Ali Nikbakht, Fatemeh Moradi, Saber Ghaffari-fam
Diabetes & Metabolism Journal.2017; 41(6): 449. CrossRef
Response: The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women (Diabetes Metab J2017;41:205-12)
Sasan Amanat, Mohammad Fararouei, Mostafa Dianatinasab
Diabetes & Metabolism Journal.2017; 41(4): 324. CrossRef
Effects of Resistance Training on Serum Inflammatory Markers and CatSper 1-4 Protein Expression in Testis of OLETF Rats
Min-Ki Lee, Se-Hwan Park, Jin-Hwan Yoon
Exercise Science.2017; 26(3): 204. CrossRef
Letter: The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women (Diabetes Metab J 2017;41:205-12)
Hye Soon Kim
Diabetes & Metabolism Journal.2017; 41(4): 322. CrossRef
Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development
Xavier Escoté, Saioa Gómez-Zorita, Miguel López-Yoldi, Iñaki Milton-Laskibar, Alfredo Fernández-Quintela, J. Martínez, María Moreno-Aliaga, María Portillo
International Journal of Molecular Sciences.2017; 18(8): 1770. CrossRef

Maximal Fat Oxidation Rate during Exercise in Korean Women with Type 2 Diabetes Mellitus: Min Hwa Suk, Yeo-Jin Moon, Sung Woo Park, Cheol-Young Park, Yun A Shin; Diabetes Metab J. 2015;39(4):328-334. Published online July 8, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.4.328

8,537 View
50 Download
16 Web of Science
11 Crossref

Abstract PDF PubReader ePub

Background

The purpose of this study was to determine the appropriate exercise intensity associated with maximum fat oxidation, improvement of body composition, and metabolic status in Korean women with type 2 diabetes mellitus (T2DM).

Methods

The study included a T2DM group (12 women) and a control group (12 women). The groups were matched in age and body mass index. The subjects performed a graded exercise test on a cycle ergometer to measure their maximal fat oxidation (Fat_max). We also measured their body composition, metabolic profiles, and mitochondrial DNA (mtDNA).

Results

The exercise intensity for Fat_max was significantly lower in the T2DM group (34.19% maximal oxygen uptake [VO₂ max]) than the control group (51.80% VO₂ max). Additionally, the rate of fat oxidation during exercise (P<0.05) and mtDNA (P<0.05) were significantly lower in the T2DM group than the control group. The VO₂ max level (P<0.001) and the insulin level (P<0.05) were positively correlated with the rate of fat oxidation.

Conclusion

The results of this study suggest lower exercise intensity that achieves Fat_max is recommended for improving fat oxidation and enhancing fitness levels in Korean women with T2DM. Our data could be useful when considering an exercise regimen to improve health and fitness.

Citations

Citations to this article as recorded by

Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise
Huiying Zhu, Jianchao Pan, Jianxuan Wen, Xiaojing Dang, Xiankun Chen, Yunxiang Fan, Weihui Lu, Wei Jiang
Frontiers in Cardiovascular Medicine.2025;[Epub] CrossRef
Methodological issues related to maximal fat oxidation and FATmax reproducibility: a narrative review
Isaac A. Chávez Guevara, Francisco J. Amaro-Gahete
International Journal of Obesity.2025; 49(10): 1984. CrossRef
Toward Exercise Guidelines for Optimizing Fat Oxidation During Exercise in Obesity: A Systematic Review and Meta-Regression
Isaac A. Chávez-Guevara, Francisco J. Amaro-Gahete, Arnulfo Ramos-Jiménez, Jean Frederic Brun
Sports Medicine.2023; 53(12): 2399. CrossRef
Cardiorespiratory fitness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis
Aline Chagastelles Pinto de Macedo, Camila Wohlgemuth Schaan, Patricia Martins Bock, Mariana Brutto de Pinto, Cintia Ehlers Botton, Daniel Umpierre, Beatriz D. Schaan
Archives of Endocrinology and Metabolism.2023;[Epub] CrossRef
Inclusion of sprints during moderate-intensity continuous exercise enhances post-exercise fat oxidation in young males
Bruno Nicanor Mello-Silva, Gabriel Völz Protzen, Fabrício Boscolo Del Vecchio
Applied Physiology, Nutrition, and Metabolism.2022; 47(2): 165. CrossRef
Resting and exercise metabolic characteristics in obese children with insulin resistance
Cao Youxiang, Zhu Lin, Chen Zekai, Xie Weijun
Frontiers in Physiology.2022;[Epub] CrossRef
Impact of Acute Eccentric versus Concentric Running on Exercise‐Induced Fat Oxidation and Postexercise Physical Activity in Untrained Men
Shaea Alkahtani, Osama Aljuhani, Nasser Alkhalidi, Naif Almasuod, Omar Hezam, Ibrahim Aljaloud, Haitham Abdel Hamid Dawoud, Ahmed Abdusalam, Danilo Sales Bocalini
BioMed Research International.2020;[Epub] CrossRef
Diurnal influences of fasted and non-fasted brisk walking on gastric emptying rate, metabolic responses, and appetite in healthy males
Victoria J. McIver, Lewis R. Mattin, Gethin H. Evans, Adora M.W. Yau
Appetite.2019; 143: 104411. CrossRef
Myokine/Adipokine Response to “Aerobic” Exercise: Is It Just a Matter of Exercise Load?
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2019;[Epub] CrossRef
Exercise as ‘precision medicine’ for insulin resistance and its progression to type 2 diabetes: a research review
Fred J. DiMenna, Avigdor D. Arad
BMC Sports Science, Medicine and Rehabilitation.2018;[Epub] CrossRef
High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes
Eva Maria Støa, Sondre Meling, Lill-Katrin Nyhus, Glenn Strømstad, Karl Magnus Mangerud, Jan Helgerud, Solfrid Bratland-Sanda, Øyvind Støren
European Journal of Applied Physiology.2017; 117(3): 455. CrossRef

Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes: Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han; Diabetes Metab J. 2014;38(6):439-448. Published online December 15, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.6.439

8,286 View
41 Download
11 Web of Science
8 Crossref

Abstract PDF PubReader ePub

Background

Arterial stiffness is an important factor in atherosclerosis. Thus we examined whether aerobic exercise could reduce arterial stiffness in obese women with type 2 diabetes without diabetic complication.

Methods

A total of 35 women with type 2 diabetes (body mass index, 26.6±2.8 kg/m²; age, 56.4±1.9 years; duration of diabetes, 4.7±4.8 years) were assigned to aerobic exercise group (AEG) or control group (CG). AEG completed a 12-week exercise program (3.6 to 5.2 metabolic equivalents, 3 day/week, 60 min/day), with their exercise activities monitored by accelerometers. We measured abdominal total fat area (TFA), visceral fat area (VFA), and subcutaneous fat area (SFA) by computed tomography, insulin sensitivity by insulin tolerance test (K_ITT), and augmentation index (AIx) by SphygmoCor at baseline and at the end of the 12-week program.

Results

The AIx was improved in the AEG compared with the CG (P<0.001). The percent change of AIx had significant correlation with the improvement of physical activity energy expenditure (PAEE), aerobic capacity, TFA, and SFA (r=-0.416, P=0.013; r=0.560, P<0.001; r=0.489, P=0.003; r=0.531, P=0.001, respectively), but not with insulin sensitivity, energy intake, or VFA.

Conclusion

Improvement in aortic stiffness by aerobic exercise is related with the improvement of aerobic capacity, PAEE, and total fat but not with insulin sensitivity or energy intake in obese women with type 2 diabetes.

Citations

Citations to this article as recorded by

Relationship between objectively measured physical activity and subclinical cardiovascular disease: a systematic review
Aparna Narendrula, Ellen Brinza, Christine Horvat Davey, Chris T Longenecker, Allison R Webel
BMJ Open Sport & Exercise Medicine.2024; 10(1): e001596. CrossRef
The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Aerobic Exercise and Weight Loss in Adults
Ahmad Jayedi, Sepideh Soltani, Alireza Emadi, Mahdieh-Sadat Zargar, Ali Najafi
JAMA Network Open.2024; 7(12): e2452185. CrossRef
Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
Diabetes/Metabolism Research and Reviews.2022;[Epub] CrossRef
Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
Obesity Reviews.2022;[Epub] CrossRef
Aortic waveform responses to insulin in late versus early chronotype with metabolic syndrome
Mary‐Margaret E. Remchak, Emily M. Heiston, Anna Ballantyne, Brielle L. Dotson, Steven K. Malin
Physiological Reports.2022;[Epub] CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
Arterial Stiffness Measured with the Cuff Oscillometric Method Is Predictive of Exercise Capacity in Patients with Cardiac Diseases
Yasushi Tazawa, Nobuyoshi Mori, Yoshiko Ogawa, Osamu Ito, Masahiro Kohzuki
The Tohoku Journal of Experimental Medicine.2016; 239(2): 127. CrossRef

Effect of Treadmill Exercise on Interleukin-15 Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats: Hee-Jae Kim, Jae Young Park, Seung Lyul Oh, Yong-An Kim, Byunghun So, Je Kyung Seong, Wook Song; Diabetes Metab J. 2013;37(5):358-364. Published online October 17, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.5.358

7,478 View
43 Download
26 Crossref

Abstract PDF PubReader ePub

Background

Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models.

Methods

Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles.

Results

After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15 was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04).

Conclusion

The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats.

Citations

Citations to this article as recorded by

Physical Activity, Exerkines, and Their Role in Cancer Cachexia
Jan Bilski, Aleksandra Szlachcic, Agata Ptak-Belowska, Tomasz Brzozowski
International Journal of Molecular Sciences.2025; 26(16): 8011. CrossRef
Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta‐analysis
Miriam Ringleb, Florian Javelle, Simon Haunhorst, Wilhelm Bloch, Lena Fennen, Sabine Baumgart, Sebastian Drube, Philipp A. Reuken, Mathias W. Pletz, Heiko Wagner, Holger H. W. Gabriel, Christian Puta
The FASEB Journal.2024;[Epub] CrossRef
The effects of gut microbiome manipulation on glycemic indices in patients with non-alcoholic fatty liver disease: a comprehensive umbrella review
Azin Vakilpour, Ehsan Amini-Salehi, Arman Soltani Moghadam, Mohammad-Hossein Keivanlou, Negin Letafatkar, Arman Habibi, Mohammad Hashemi, Negar Eslami, Reza Zare, Naeim Norouzi, Hamed Delam, Farahnaz Joukar, Fariborz Mansour-Ghanaei, Soheil Hassanipour, S
Nutrition & Diabetes.2024;[Epub] CrossRef
Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism
Linjing Yan, Liang Guo
Journal of Cellular Physiology.2023; 238(8): 1670. CrossRef
Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats
Luciele Guerra Minuzzi, Luciana Renata da Conceição, Vitor Rosetto Muñoz, Renan Fudoli Lins Vieira, Rafael Calais Gaspar, Adelino S.R. da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Ana Maria Teixeira, José Rodrigo Pauli
Cytokine.2021; 137: 155306. CrossRef
Swimming Program on Mildly Diabetic Rats in Pregnancy
Nathália C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Débora C. Damasceno
Reproductive Sciences.2021; 28(8): 2223. CrossRef
Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari, Hassan Tavassoli
Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef
Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview
Jenny Hyosun Kwon, Kyoung Min Moon, Kyueng-Whan Min
Healthcare.2020; 8(4): 378. CrossRef
Myokine/Adipokine Response to “Aerobic” Exercise: Is It Just a Matter of Exercise Load?
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2019;[Epub] CrossRef
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle
Taku Fujimoto, Ken Sugimoto, Toshimasa Takahashi, Yukiko Yasunobe, Keyu Xie, Minoru Tanaka, Yuri Ohnishi, Shino Yoshida, Hitomi Kurinami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi
Biochemical and Biophysical Research Communications.2019; 509(4): 994. CrossRef
Insights from Exercise-induced Cardioprotection-from Clinical Application to Basic Research
Hao Jiang, Beijian Zhang, Daile Jia, Wenlong Yang, Aijun Sun, Junbo Ge
Current Pharmaceutical Design.2019; 25(35): 3751. CrossRef
Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2018;[Epub] CrossRef
A systematic review of “myokines and metabolic regulation”
Henry H. León-Ariza, María P. Mendoza-Navarrete, María I. Maldonado-Arango, Daniel A. Botero-Rosas
Apunts. Medicina de l'Esport.2018; 53(200): 155. CrossRef
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Carmen Fiuza-Luces, Alejandro Santos-Lozano, Michael Joyner, Pedro Carrera-Bastos, Oscar Picazo, José L. Zugaza, Mikel Izquierdo, Luis M. Ruilope, Alejandro Lucia
Nature Reviews Cardiology.2018; 15(12): 731. CrossRef
Effects of 8 Weeks Resistance Exercise on GSH, SOD, TBARS Activities and GLUT2 mRNA Expression of Pancreas in OLETF Rats
Min-Ki Lee, Jin-Hwan Yoon
The Korean Journal of Physical Education.2017; 56(3): 551. CrossRef
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function
B C S Boa, J S Yudkin, V W M van Hinsbergh, E Bouskela, E C Eringa
British Journal of Pharmacology.2017; 174(20): 3466. CrossRef
IL15RA is required for osteoblast function and bone mineralization
Emanuele Loro, Girish Ramaswamy, Abhishek Chandra, Wei-Ju Tseng, Manoj K. Mishra, Eileen M. Shore, Tejvir S. Khurana
Bone.2017; 103: 20. CrossRef
Interleukin‐15 in obesity and metabolic dysfunction: current understanding and future perspectives
Y. Duan, F. Li, W. Wang, Q. Guo, C. Wen, Y. Li, Y. Yin
Obesity Reviews.2017; 18(10): 1147. CrossRef
Effects of interval aerobic training combined with strength exercise on body composition, glycaemic and lipid profile and aerobic capacity of obese rats
Irene Coll-Risco, Virginia A. Aparicio, Elena Nebot, Daniel Camiletti-Moirón, Rosario Martínez, Garyfallia Kapravelou, María López-Jurado, Jesús M. Porres, Pilar Aranda
Journal of Sports Sciences.2016; 34(15): 1452. CrossRef
Exercise-induced alterations in pancreatic oxidative stress and mitochondrial function in type 2 diabetic Goto-Kakizaki rats
Haider Raza, Annie John, Jasmin Shafarin, Frank C. Howarth
Physiological Reports.2016; 4(8): e12751. CrossRef
Interval aerobic training combined with strength-endurance exercise improves metabolic markers beyond caloric restriction in Zucker rats
V.A. Aparicio, I. Coll-Risco, D. Camiletti-Moirón, E. Nebot, R. Martínez, M. López-Jurado, P. Aranda
Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(8): 713. CrossRef
IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats
Hong-Tao Yang, Li-Jie Luo, Wen-Jia Chen, Lei Zhao, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang
Endocrine.2015; 48(1): 152. CrossRef
Time course of IL-15 expression after acute resistance exercise in trained rats: effect of diabetes and skeletal muscle phenotype
Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan, LeBris S. Quinn, Reza Gharakhanlou, Leila Baghersad, Mehdi Mahdavi
Endocrine.2015; 49(2): 396. CrossRef
The search for exercise factors in humans
Milène Catoire, Sander Kersten
The FASEB Journal.2015; 29(5): 1615. CrossRef
Muscle-specific deletion of exons 2 and 3 of theIL15RAgene in mice: effects on contractile properties of fast and slow muscles
Grant O'Connell, Ge Guo, Janelle Stricker, LeBris S. Quinn, Averil Ma, Emidio E. Pistilli
Journal of Applied Physiology.2015; 118(4): 437. CrossRef
Exercise-induced myokines in health and metabolic diseases
Byunghun So, Hee-Jae Kim, Jinsoo Kim, Wook Song
Integrative Medicine Research.2014; 3(4): 172. CrossRef

Reviews

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate: Dumitru Constantin-Teodosiu; Diabetes Metab J. 2013;37(5):301-314. Published online October 17, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.5.301

12,020 View
101 Download
47 Crossref

Abstract PDF PubReader ePub

Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the skeletal muscle insulin resistance, metabolic syndrome, and the onset of type 2 diabetes (T2D). There are also situations where muscle insulin resistance can occur independently from high-fat dietary intake such as sepsis, inflammation, or drug administration though they all may share the same underlying mechanism, i.e., via activation of forkhead box family of transcription factors, and to a lower extent via peroxisome proliferator-activated receptors. The main feature of T2D is a chronic elevation in blood glucose levels. Chronic systemic hyperglycaemia is toxic and can lead to cellular dysfunction that may become irreversible over time due to deterioration of the pericyte cell's ability to provide vascular stability and control to endothelial proliferation. Therefore, it may not be surprising that T2D's complications are mainly macrovascular and microvascular related, i.e., neuropathy, retinopathy, nephropathy, coronary artery, and peripheral vascular diseases. However, life style intervention such as exercise, which is the most potent physiological activator of muscle PDC, along with pharmacological intervention such as administration of dichloroacetate or L-carnitine can prove to be viable strategies for treating muscle insulin resistance in obesity and T2D as they can potentially restore whole body glucose disposal.

Citations

Citations to this article as recorded by

Oxidative stress and metabolism meet epigenetic modulation in physical exercise
José Luis García-Giménez, Irene Cánovas-Cervera, Federico V. Pallardó
Free Radical Biology and Medicine.2024; 213: 123. CrossRef
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
Peter W. Stacpoole, Charles E. McCall
Mitochondrion.2023; 70: 59. CrossRef
Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger
Nick Schoenmann, Nicholas Tannenbaum, Ryan M. Hodgeman, Raghavan Pillai Raju
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(7): 166769. CrossRef
Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls
Héctor F. Escobar-Morreale, María Ángeles Martínez-García, María Insenser, Nicolau Cañellas, Xavier Correig, Manuel Luque-Ramírez
Biology of Sex Differences.2023;[Epub] CrossRef
Metabolomics and mitochondrial dysfunction in cardiometabolic disease
Abhishek Shastry, Kimberly Dunham-Snary
Life Sciences.2023; 333: 122137. CrossRef
Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee
Journal of Diabetes Investigation.2021; 12(1): 21. CrossRef
Targeting pyruvate dehydrogenase kinase signaling in the development of effective cancer therapy
Saleha Anwar, Anas Shamsi, Taj Mohammad, Asimul Islam, Md. Imtaiyaz Hassan
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(1): 188568. CrossRef
Effect of exercise training on skeletal muscle protein expression in relation to insulin sensitivity: Per‐protocol analysis of a randomized controlled trial (GO‐ACTIWE)
Lea Bruhn, Rasmus Kjøbsted, Jonas Salling Quist, Anne Sofie Gram, Mads Rosenkilde, Kristine Færch, Jørgen F.P. Wojtaszewski, Bente Stallknecht, Martin Bæk Blond
Physiological Reports.2021;[Epub] CrossRef
The Mechanism behind Influenza Virus Cytokine Storm
Yinuo Gu, Xu Zuo, Siyu Zhang, Zhuoer Ouyang, Shengyu Jiang, Fang Wang, Guoqiang Wang
Viruses.2021; 13(7): 1362. CrossRef
Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
Nives Škorja Milić, Klemen Dolinar, Katarina Miš, Urška Matkovič, Maruša Bizjak, Mojca Pavlin, Matej Podbregar, Sergej Pirkmajer
International Journal of Molecular Sciences.2021; 22(16): 8610. CrossRef
The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis
Hannah Crossland, Dumitru Constantin-Teodosiu, Paul L. Greenhaff
International Journal of Molecular Sciences.2021; 22(18): 9775. CrossRef
PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes
Hung-Che Chien, Despina Constantin, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
Biology.2021; 10(11): 1098. CrossRef
Molecular Mechanisms of Muscle Fatigue
Dumitru Constantin-Teodosiu, Despina Constantin
International Journal of Molecular Sciences.2021; 22(21): 11587. CrossRef
Coronavirus Disease-19 (COVID-19) and Modern Lifestyle Diseases
Pallav Sengupta, Sulagna Dutta
Biomedical and Pharmacology Journal.2021; 14(4): 2245. CrossRef
A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes
Adam J. Bittel, Daniel C. Bittel, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Jun Yoshino, Lane C. Porter, Nada A. Abumrad, Dominic N. Reeds, W. Todd Cade
Diabetologia.2020; 63(3): 611. CrossRef
An integrative approach to the regulation of mitochondrial respiration during exercise: Focus on high-intensity exercise
Jose A.L. Calbet, Saúl Martín-Rodríguez, Marcos Martin-Rincon, David Morales-Alamo
Redox Biology.2020; 35: 101478. CrossRef
PPARδ and FOXO1 Mediate Palmitate-Induced Inhibition of Muscle Pyruvate Dehydrogenase Complex and CHO Oxidation, Events Reversed by Electrical Pulse Stimulation
Hung-Che Chien, Paul L. Greenhaff, Dumitru Constantin-Teodosiu
International Journal of Molecular Sciences.2020; 21(16): 5942. CrossRef
Cancer cachexia has many symptoms but only one cause: anoxia
Tomas Koltai
F1000Research.2020; 9: 250. CrossRef
Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds
Jihoon Kang, Haushabhau S. Pagire, Donguk Kang, Yo Han Song, In Kyu Lee, Kang Taek Lee, Chin-Ju Park, Jin Hee Ahn, Jungwook Kim
Biochemical and Biophysical Research Communications.2020; 527(3): 778. CrossRef
Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
Livio Luzi, Maria Grazia Radaelli
Acta Diabetologica.2020; 57(6): 759. CrossRef
Changes in gene expression of lactate carriers (MCT1 and CD147) in cardiac muscle of diabetic male rats: the effect of dichloroacetate and endurance training
H. Rezaeinasab, A. Habibi, M. Nikbakht, M. Rashno, S. Shakerian
The Ukrainian Biochemical Journal.2020; 92(5): 111. CrossRef
Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li
Diabetes.2019; 68(12): 2197. CrossRef
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice
Takuya Ohba, Shinichi Domoto, Miyu Tanaka, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara
Biological and Pharmaceutical Bulletin.2019; 42(7): 1140. CrossRef
The Beta Cell in Type 2 Diabetes
Ashley A. Christensen, Maureen Gannon
Current Diabetes Reports.2019;[Epub] CrossRef
Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
Scientific Reports.2018;[Epub] CrossRef
PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels
Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
Diabetes.2018; 67(10): 2054. CrossRef
Differences in Muscle Metabolism Between Triathletes and Normally Active Volunteers Investigated Using Multinuclear Magnetic Resonance Spectroscopy at 7T
Radka Klepochová, Ladislav Valkovič, Thomas Hochwartner, Christoph Triska, Norbert Bachl, Harald Tschan, Siegfried Trattnig, Michael Krebs, Martin Krššák
Frontiers in Physiology.2018;[Epub] CrossRef
Defining the contribution of skeletal muscle pyruvate dehydrogenase α1 to exercise performance and insulin action
Kristoffer Svensson, Jessica R. Dent, Shahriar Tahvilian, Vitor F. Martins, Abha Sathe, Julien Ochala, Mulchand S. Patel, Simon Schenk
American Journal of Physiology-Endocrinology and Metabolism.2018; 315(5): E1034. CrossRef
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
María Isabel Hernández-Alvarez, Angels Díaz-Ramos, María Berdasco, Jeff Cobb, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzystof Wanic, Declan O’Hanlon, Antonio Gomez, Laura R. de la Ballina, Manel Esteller, Manuel Palacin, Donal J. O’Gorman, Joh
Scientific Reports.2017;[Epub] CrossRef
Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer
Peter W Stacpoole
JNCI: Journal of the National Cancer Institute.2017;[Epub] CrossRef
Hyperpalatable Diet and Physical Exercise Modulate the Expression of the Glial Monocarboxylate Transporters MCT1 and 4
Luis V. Portela, Andressa W. Brochier, Clarissa B. Haas, Afonso Kopczynski de Carvalho, Jussania A. Gnoato, Eduardo R. Zimmer, Eduardo Kalinine, Luc Pellerin, Alexandre P. Muller
Molecular Neurobiology.2017; 54(8): 5807. CrossRef
Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock
Kumar Subramani, Sumin Lu, Marie Warren, Xiaogang Chu, Haroldo A. Toque, R. William Caldwell, Michael P. Diamond, Raghavan Raju
Scientific Reports.2017;[Epub] CrossRef
The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate‐intensity exercise in human skeletal muscle
A. Vigelsø, M. Gram, R. Dybboe, A. B. Kuhlman, C. Prats, P. L. Greenhaff, D. Constantin‐Teodosiu, J. B. Birk, J. F. P. Wojtaszewski, F. Dela, J. W. Helge
The Journal of Physiology.2016; 594(8): 2339. CrossRef
Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum
Michael A. Moxley, Daniel A. Beard, Jason N. Bazil
Journal of Biological Chemistry.2016; 291(6): 2712. CrossRef
Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
Scientific Reports.2016;[Epub] CrossRef
Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A
S.A. Ljunggren, M. Iggland, M. Rönn, L. Lind, P.M. Lind, H. Karlsson
Toxicology.2016; 347-349: 6. CrossRef
Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
Bjorn T. Tam, Xiao M. Pei, Benjamin Y. Yung, Shea P. Yip, Lawrence W. Chan, Cesar S. Wong, Parco M. Siu
Pflügers Archiv - European Journal of Physiology.2015; 467(12): 2555. CrossRef
Sex-related differences in the effects of high-fat diets on DHEA-treated rats
Ana Lúcia Cecconello, Marcia Trapp, Ana Lúcia Hoefel, Cláudia Vieira Marques, Bruno Dutra Arbo, Gabriela Osterkamp, Luiz Carlos Rios Kucharski, Maria Flávia Marques Ribeiro
Endocrine.2015; 48(3): 985. CrossRef
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
Sergio Arrabal, Miguel Angel Lucena, Miren Josune Canduela, Almudena Ramos-Uriarte, Patricia Rivera, Antonia Serrano, Francisco Javier Pavón, Juan Decara, Antonio Vargas, Elena Baixeras, Mercedes Martín-Rufián, Javier Márquez, Pedro Fernández-Llébrez, Bau
PLOS ONE.2015; 10(12): e0145244. CrossRef
A glance at … exercise and glucose uptake
Michael J. Glade, Kyl Smith
Nutrition.2015; 31(6): 893. CrossRef
Perpetual muscle PDH activation in PDH kinase knockout mice protects against high-fat feeding–induced muscle insulin resistance
Dumitru Constantin-Teodosiu, Francis B. Stephens, Paul L. Greenhaff
Proceedings of the National Academy of Sciences.2015;[Epub] CrossRef
Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial Content
Craig A. Goodman, Derk Pol, Evelyn Zacharewicz, Robert S. Lee-Young, Rod J. Snow, Aaron P. Russell, Glenn K. McConell, Ashok Kumar
PLOS ONE.2015; 10(5): e0128398. CrossRef
13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet, Marta Cascante
BMC Systems Biology.2014;[Epub] CrossRef
Translational Research: From Biological Discovery to Public Benefit (or Not)
Michael R. Emmert-Buck
Advances in Biology.2014; 2014: 1. CrossRef
Diabetic Worker with History of Falls: A Case Study
Ann R. Lurati
Workplace Health & Safety.2014; 62(5): 175. CrossRef
Diabetic Worker With History of Falls: A Case Study
Ann R. Lurati
Workplace Health & Safety.2014; 62(5): 175. CrossRef
Mitochondrial Pyruvate Carrier 2 Hypomorphism in Mice Leads to Defects in Glucose-Stimulated Insulin Secretion
Patrick A. Vigueira, Kyle S. McCommis, George G. Schweitzer, Maria S. Remedi, Kari T. Chambers, Xiaorong Fu, William G. McDonald, Serena L. Cole, Jerry R. Colca, Rolf F. Kletzien, Shawn C. Burgess, Brian N. Finck
Cell Reports.2014; 7(6): 2042. CrossRef

Effects of Exercise Alone on Insulin Sensitivity and Glucose Tolerance in Obese Youth: SoJung Lee, YoonMyung Kim; Diabetes Metab J. 2013;37(4):225-232. Published online August 14, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.4.225

8,011 View
62 Download
19 Crossref

Abstract PDF PubReader ePub

As with the dramatic increases in childhood obesity over the past decades, the incidence of type 2 diabetes has increased among children and adolescents in the United States. Insulin resistance is a common feature of childhood obesity and increases the risk of type 2 diabetes, metabolic syndrome, and atherogenic lipoprotein profile in obese youth. Although cross-sectional studies report beneficial effects of physical activity or cardiorespiratory fitness on insulin sensitivity, the role of regular exercise alone (e.g., no calorie restriction) as a strategy to reduce the risk of type 2 diabetes is unclear in obese children and adolescents. In this mini review, we examined the independent effects of various exercise on glucose tolerance and insulin sensitivity in obese youth.

Citations

Citations to this article as recorded by

Obesity blunts insulin sensitivity improvements and attenuates strength gains following resistance training in nondiabetic men
Ramzi A. Al-Horani, Khaled M. Alsays, Osama Abo Alrob
European Journal of Applied Physiology.2024; 124(5): 1425. CrossRef
Lifestyle and Pharmacological Interventions and Treatment Indications for the Management of Obesity in Children and Adolescents
Despina Herouvi, George Paltoglou, Alexandra Soldatou, Christina Kalpia, Spyridon Karanasios, Kyriaki Karavanaki
Children.2023; 10(7): 1230. CrossRef
Predictors of postprandial glycaemia, insulinaemia and insulin resistance in adolescents
Ryan A. Williams, Karah J. Dring, Simon B. Cooper, John G. Morris, Caroline Sunderland, Mary E. Nevill
British Journal of Nutrition.2021; 125(10): 1101. CrossRef
HHOM-051608 A Whey Protein Formulation Fortified with Herbal Actives Improves Exercise Performance and Muscle Strength
Kamlesh K. Vishwakarma, Madan M. Narendra, Mohammed M. Azeemuddin, Poornima Shankar, Prathibha Babshet, Mohamed Rafiq, Uddagiri V. Babu
International Journal of Nutrition, Pharmacology, Neurological Diseases.2021; 11(1): 80. CrossRef
New insights into the pharmacological treatment of pediatric patients with type 2 diabetes
Tatsuhiko Urakami
Clinical Pediatric Endocrinology.2018; 27(1): 1. CrossRef
Effect of 7 days of exercise on exogenous carbohydrate oxidation and insulin resistance in children with obesity
Lisa Chu, Katherine M. Morrison, Michael C. Riddell, Sandeep Raha, Brian W. Timmons
Applied Physiology, Nutrition, and Metabolism.2018; 43(7): 677. CrossRef
12-Week aerobic exercise and nutritional program minimized the presence of the 64Arg allele on insulin resistance
Gerusa E. Milano-Gai, Lupe Furtado-Alle, Jorge Mota, Leilane Lazarotto, Gisele E. Milano, Ricardo R. de Souza Lehtonen, Ana C.K. Titski, Íncare C. Jesus, Luciane V. Tureck, Rosana B. Radominski, Manuel João Coelho-e-Silva, Neiva Leite
Journal of Pediatric Endocrinology and Metabolism.2018; 31(9): 1033. CrossRef
ADRB2 Gln27Glu polymorphism influenced changes in leptin but not body composition or metabolic and other inflammatory parameters after twelve weeks of combined training in overweight adolescents
Neiva Leite, Larissa Rosa da Silva, Íncare Correa de Jesus, Wendell Arthur Lopes, Claudia Regina Cavaglieri, Cássio Leandro Consentino, Rosana Bento Radominski, Ricardo Lehtonen Rodrigues de Souza, Luciane Viater Tureck, Lupe Furtado-Alle
Motriz: Revista de Educação Física.2018;[Epub] CrossRef
Patterns of Physical Activity Adherence by Adolescents With Diabetes or Obesity Enrolled in a Personalized Community-Based Intervention
Sara F. Michaliszyn, Melinda Higgins, Melissa Spezia Faulkner
The Diabetes Educator.2018; 44(6): 519. CrossRef
Diet Quality and Mortality Risk in Metabolically Obese Normal-Weight Adults
Yong-Moon Mark Park, Teresa T. Fung, Susan E. Steck, Jiajia Zhang, Linda J. Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T. Merchant
Mayo Clinic Proceedings.2016; 91(10): 1372. CrossRef
Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes
Y-M Park, S E Steck, T T Fung, J Zhang, L J Hazlett, K Han, A T Merchant
International Journal of Obesity.2016; 40(10): 1541. CrossRef
Efeitos metabólicos do exercício físico na obesidade infantil: uma visão atual
Santiago Tavares Paes, João Carlos Bouzas Marins, Ana Eliza Andreazzi
Revista Paulista de Pediatria.2015; 33(1): 122. CrossRef
Metabolic effects of exercise on childhood obesity: a current view
Santiago Tavares Paes, João Carlos Bouzas Marins, Ana Eliza Andreazzi
Revista Paulista de Pediatria (English Edition).2015; 33(1): 122. CrossRef
Impact of regular physical activity on blood glucose control and cardiovascular risk factors in adolescents with type 2 diabetes mellitus - a multicenter study of 578 patients from 225 centres
A Herbst, T Kapellen, E Schober, C Graf, T Meissner, RW Holl
Pediatric Diabetes.2015; 16(3): 204. CrossRef
Impact of exercise training without caloric restriction on inflammation, insulin resistance and visceral fat mass in obese adolescents
M. Mendelson, A.‐S. Michallet, D. Monneret, C. Perrin, F. Estève, P. R. Lombard, P. Faure, P. Lévy, A. Favre‐Juvin, J.‐L. Pépin, B. Wuyam, P. Flore
Pediatric Obesity.2015; 10(4): 311. CrossRef
Early-life sleep deprivation persistently depresses melatonin production and bio-energetics of the pineal gland: potential implications for the development of metabolic deficiency
Li-You Chen, Cheng Tiong, Chung-Hung Tsai, Wen-Chieh Liao, Shun-Fa Yang, Su-Chung Youn, Fu-Der Mai, Hung-Ming Chang
Brain Structure and Function.2015; 220(2): 663. CrossRef
Whey Protein Improves Exercise Performance and Biochemical Profiles in Trained Mice
WEN-CHYUAN CHEN, WEN-CHING HUANG, CHIEN-CHAO CHIU, YU-KAI CHANG, CHI-CHANG HUANG
Medicine & Science in Sports & Exercise.2014; 46(8): 1517. CrossRef
Type 2 diabetes in the child and adolescent
Phil Zeitler, Junfen Fu, Nikhil Tandon, Kristen Nadeau, Tatsuhiko Urakami, Timothy Barrett, David Maahs
Pediatric Diabetes.2014; 15(S20): 26. CrossRef
ENDOCRINOLOGY AND ADOLESCENCE: Aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials
Antonio García-Hermoso, Jose M Saavedra, Yolanda Escalante, Mairena Sánchez-López, Vicente Martínez-Vizcaíno
European Journal of Endocrinology.2014; 171(4): R163. CrossRef

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity: Hayley M. O'Neill; Diabetes Metab J. 2013;37(1):1-21. Published online February 15, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.1.1

30,074 View
348 Download
216 Crossref

Abstract PDF PubReader ePub

AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).

Citations

Citations to this article as recorded by

Exercise-induced stress pathways: Crosstalk between AMPK, HSPs, and inflammation
Lijuan Xiang, Zhanguo Su
Journal of Investigative Medicine.2026; 74(2): 95. CrossRef
Therapeutic effects of Angelica gigas Nakai in experimental rat model of polycystic ovary syndrome with network pharmacology
Bomee Lee, Go Woon Lee, La Yoon Choi, Sujin Kwon, Yong-Deok Jeon, Mi Hye Kim, Sae Hun Kim
Food Science and Biotechnology.2026; 35(1): 285. CrossRef
Residential Greenness and Subtypes of Gestational Diabetes Mellitus: A Metabolomic Investigation
Jun Cao, Wen Jiang, Tian Zhang, Zhichao Yuan, Dongjian Yang, Liu Liu, Qingli Zhang, Jun Zhang
Ecotoxicology and Environmental Safety.2026; 309: 119667. CrossRef
Improvements in glucose metabolism after high-, but not low-, volume strength exercise in individuals with obesity are associated with baseline insulin resistance: a secondary analysis from a randomized clinical trial
Luis Filipe Rocha Silva, Paulo H. Evangelista Silva, Jordan Ottoni do Carmo, Bruna Caroline Chaves Garcia, Elizabethe Adriana Esteves, Marco Fabrício Dias-Peixoto, Fernando Gripp, Oscar Chavez, Valmor Tricoli, Zachary Aaron Mang, Fabiano Trigueiro Amorim,
European Journal of Applied Physiology.2026;[Epub] CrossRef
Nur77 Regulates the Phosphorylation of Smad3, Thereby Influencing Skeletal Muscle Fibrosis Caused by Obesity
Na Li, Tingting Tian, Qihe Zhao, Difei Wang
The FASEB Journal.2026;[Epub] CrossRef
Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
Abduldaheem Turki Jalil, Hassan Hadi Al-Kazzaz, Firas A. Hassan, Safaa Halool Mohammed, Muna S. Merza, Tahani Aslandook, Ahmed Elewadi, Ali Fadhil, Ali Alsalamy
Indian Journal of Clinical Biochemistry.2025; 40(2): 165. CrossRef
1-Deoxynojirimycin affects high glucose-induced pancreatic beta-cell dysfunction through regulating CEBPA expression and AMPK pathway
Xiaoying Li, Shenggui Liu, Siqi Wang, Xinghui Ai, Lin Wei
Biochemistry and Cell Biology.2025; 103: 1. CrossRef
Myogenic differentiation markers in muscle tissue after aerobic training
Rastegar Hoseini, Zahra Hoseini, Ayob Kamangar
Heliyon.2025; 11(2): e41888. CrossRef
Tomatine Improves Glucose Metabolism and Mitochondrial Respiration in Insulin-Resistant Hepatocyte Cell Lines AML12 and HepG2 via an AMP-Activated Protein Kinase-Dependent Pathway
Yu Geon Lee, Donghwan Kim
Cells.2025; 14(5): 329. CrossRef
The Combined Effect of High-Intensity Interval Training and Time-Restricted Feeding on the AKT-IGF-1-mTOR Signaling Pathway in the Muscle Tissue of Type 2 Diabetic Rats
Motahareh Mohebinejad, Fatemeh Kazeminasab, Mahtab Ghanbari Rad, Reza Bagheri, Mazdak Razi, Darryn Willoughby, Fred Dutheil
Nutrients.2025; 17(9): 1404. CrossRef
Meeting physical activity and resistance exercise guidelines associated with significantly reduced prevalence of diabetes in older adults
Chiho Kim, Dong-Hyuk Park, YongJun Lee, Eun Chan Kim, Chang-geun Oh, Dong Hoon Lee, Justin Y Jeon
Age and Ageing.2025;[Epub] CrossRef
Insulin resistance mediates the association between physical activity and mortality in US adults with metabolic syndrome
Kedi Gao, Youliang Lin
Scientific Reports.2025;[Epub] CrossRef
Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain–muscle–liver axis to slow down aging and neurodegeneration: a narrative review
Jianda Kong, Yingao Xie, Rao Fan, Qinglu Wang, Ying Luo, Panpan Dong
European Journal of Medical Research.2025;[Epub] CrossRef
The Role of Seaweed Derived Bioactive Compounds in Preventing Cellular Senescence and Aging
Hiruni S Kumarasinghe, Thilina L Gunathilaka
Natural Product Communications.2025;[Epub] CrossRef
Impact of polymorphisms on gene expression and splicing in response to exercise and diet-induced weight loss in human skeletal muscle tissues
Wenjing Wang, Wei Lin Liew, Shiqi Huang, Edmund Chan, Amelia Li Min Tan, Chi Tian, Yihan Tong, Yuntian Zhang, Fei Liu, Yixian Qin, Sean Jun Leong Ou, Suresh Anand Sadananthan, Sambasivam Sendhil Velan, Kavita Venkataraman, Sarah R. Langley, Petretto Enric
Cell Genomics.2025; 5(9): 100951. CrossRef
Keel Bone Damage in Commercial Laying Hen Hybrids
N. Abdallah, K. Kursun, M. Baylan
Veterinary Medicine and Science.2025;[Epub] CrossRef
AMPK/mTOR balance during exercise: implications for insulin resistance in aging muscle
Xie Mingzheng, Weng You
Molecular and Cellular Biochemistry.2025; 480(12): 5941. CrossRef
The Impact of Aerobic vs. Resistance Exercises on Serum miR-204, miR-181, Metabolic Biomarkers and Physical Fitness in Diabetic Children: A Randomized Control Trial
Mohammad Ali Shams, Vazgen Minasian, Mahin Hashemipour, Silva Hovsepian
Zahedan Journal of Research in Medical Sciences.2025;[Epub] CrossRef
Physical activity and glioblastoma: a paradigm shift in neuro-oncology therapy
Lin Xie, Feng Wang
Frontiers in Oncology.2025;[Epub] CrossRef
Antidiabetic potential of Gynura procumbens (Lour.) Merr.: a review of in vitro and in vivo studies
Nurul Hafizah Mohd Nor, Farah Hanan Fathihah Jaffar, Mohd Izhar Ariff Mohd Kashim, Mohd Helmy Mokhtar
Frontiers in Pharmacology.2025;[Epub] CrossRef
Effects of different exercise prescription parameters on metabolic and inflammatory biomarkers in cancer patients: a systematic review, meta-analysis, and meta-regression
Jingyu Wang, Yuxuan He, Ziqian Wang, Zhouluo Wang, Yongqi Miao, Jae-Young Choi
Frontiers in Immunology.2025;[Epub] CrossRef
Therapeutic Potential of Citrus Species Against Metabolic Syndrome: Insights from Preclinical and Clinical Studies
Punam Kumari, Pervej Alom Barbhuiya, Manash Pratim Pathak
Current Nutrition Reports.2025;[Epub] CrossRef
Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium
Kanittha Chantarasakha, Arunrat Yangchum, Masahiko Isaka, Surapun Tepaamorndech
Natural Products and Bioprospecting.2025;[Epub] CrossRef
Impact of Arabinoxylan Consumption on Glycemic Control: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies
Yujing Xu, Yuxin Liang, Jung Eun Kim
Nutrients.2025; 17(17): 2840. CrossRef
Mixed twitch and tetanus electrical stimulation via belt-electrode effectively attenuates denervation-induced muscle atrophy
Hiroyuki Uno, Mako Isemura, Shohei Kamiya, Ryuji Akimoto, Katsu Hosoki, Shunta Tadano, Karina Kouzaki, Yuki Tamura, Takaya Kotani, Koichi Nakazato, Atsushi Asakura,
PLOS One.2025; 20(10): e0334691. CrossRef
Ayurvedic perspective of mitochondrial dysfunction and vitiation of Meda Dhatu in obesity (Sthaulya) through insights from quantum biology
Dhara Nileshkumar Deliwala, Yogesh Shamrao Deole
Journal of Drug Research in Ayurvedic Sciences.2025; 10(Suppl 2): S144. CrossRef
THE IMPACT OF VARIOUS LIFESTYLE FACTORS ON BLOOD GLUCOSE CONTROL IN INDIVIDUALS WITH TYPE 2 DIABETES: A REVIEW OF CURRENT RESEARCH AND CLINICAL RECOMMENDATIONS
Ryszard Łagowski, Julia Kosęda, Honorata Juniewicz, Zuzanna Kudlińska, Patryk Heryć, Karolina Kananowicz, Zofia Laska, Marianna Latour, Anna Jędrasiak, Jakub Piotrowski
International Journal of Innovative Technologies in Social Science.2025;[Epub] CrossRef
Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and muscles of high fat diet-fed rats
Zakiah N. Almohawes, Attalla El-Kott, Kareem Morsy, Ali A. Shati, Ayman E. El-Kenawy, Heba S. Khalifa, Fahmy G. Elsaid, Abd-El-Karim M. Abd-Lateif, Ahmed Abu-Zaiton, Eman R. Ebealy, Mohamed M. Abdel-Daim, Reham A. Ghanem, Eman M. Abd-Ella
Archives of Physiology and Biochemistry.2024; 130(3): 257. CrossRef
Risks and benefits of salicylates in food: a narrative review
Joanna Suliburska, Rafsan Syabani Cholik
Nutrition Reviews.2024; 82(11): 1594. CrossRef
Effectiveness of Combined Aerobic and Resistance Exercise on Cognition, Metabolic Health, Physical Function, and Health-related Quality of Life in Middle-aged and Older Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
Jinghua Zhang, Wilson Wai San Tam, Kanokwan Hounsri, Joji Kusuyama, Vivien Xi Wu
Archives of Physical Medicine and Rehabilitation.2024; 105(8): 1585. CrossRef
Molecular mechanisms underlying sarcopenia in heart failure
Cody A. Rutledge
The Journal of Cardiovascular Aging.2024;[Epub] CrossRef
Diarrhea induced by insufficient fat absorption in weaned piglets: Causes and nutrition regulation
Yuying Li, Pengjun Shi, Kang Yao, Qian Lin, Mansheng Wang, Zhenping Hou, Wenjie Tang, Hui Diao
Animal Nutrition.2024; 16: 299. CrossRef
Small peptides: could they have a big role in metabolism and the response to exercise?
Muhammed M. Atakan, İbrahim Türkel, Berkay Özerkliğ, Şükran N. Koşar, Dale F. Taylor, Xu Yan, David J. Bishop
The Journal of Physiology.2024; 602(4): 545. CrossRef
The genetic and dietary landscape of the muscle insulin signalling network
Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
eLife.2024;[Epub] CrossRef
Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation
Liang Wang, Yang Qiao, Jingzhi Yu, Qihao Wang, Xinyu Wu, Qiqi Cao, Zeyu Zhang, Zhen Feng, Huan He
Redox Biology.2024; 70: 103079. CrossRef
The genetic and dietary landscape of the muscle insulin signalling network
Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
eLife.2024;[Epub] CrossRef
AMPK activation modulates IL‐36‐induced inflammatory responses by regulating IκBζ expression in the skin
Yi‐Ting Huang, Ling‐Ya Chiu, Po‐Hsuan Lu, Pa‐Fan Hsiao, Jen‐Yu Wang, Ping‐Hsun Lu, Nan‐Lin Wu
British Journal of Pharmacology.2024; 181(15): 2429. CrossRef
Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
Manar Mohammed El Tabaa, Maram Mohammed El Tabaa, Eman Rashad, Mohammed Salah Elballal, Ola Elazazy
International Immunopharmacology.2024; 132: 111954. CrossRef
Exercise-Mediated Protection against Air Pollution-Induced Immune Damage: Mechanisms, Challenges, and Future Directions
Xingsheng Jin, Yang Chen, Bingxiang Xu, Haili Tian
Biology.2024; 13(4): 247. CrossRef
The beneficial effects of metformin inclusion on growth performance, glucose utilization, antioxidant capacity and apoptosis of largemouth bass (Micropterus salmoides) fed with high dietary carbohydrates
Xiaoyuan Wang, Ye Gong, Wenfei Li, Ning Liu, Zishuo Fang, Nihe Zhang, Naisong Chen, Songlin Li
Aquaculture.2024; 588: 740957. CrossRef
Anthracycline Cardiotoxicity Induces Progressive Changes in Myocardial Metabolism and Mitochondrial Quality Control
Anabel Díaz-Guerra, Rocío Villena-Gutiérrez, Agustín Clemente-Moragón, Mónica Gómez, Eduardo Oliver, Miguel Fernández-Tocino, Carlos Galán-Arriola, Laura Cádiz, Borja Ibáñez
JACC: CardioOncology.2024; 6(2): 217. CrossRef
Exploring the Potential of Ribes nigrum L., Aronia melanocarpa (Michx.) Elliott, and Sambucus nigra L. Fruit Polyphenol‐Rich Composition and Metformin Synergy in Type 2 Diabetes Management
Katarzyna Zima, Barbara Khaidakov, Laura Banaszkiewicz, Krzysztof Lemke, Paulina Karolina Kowalczyk, Manishekhar Kumar
Journal of Diabetes Research.2024;[Epub] CrossRef
Exercise intervention may play a potential therapeutic role in patients with glioblastoma multiforme (Review)
Salaheddin Sharif, Nicholas Harman, David Hydock, Thomas Olson
World Academy of Sciences Journal.2024;[Epub] CrossRef
The Impact of Organized Exercise and Non-organized Leisured Time Activity on Serum Pentraxin3 and C-reactive Protein Levels, Lipid Profile and Physical Fitness in Diabetic Children
Maryam Nazari, Vazgen Minasian
Asian Journal of Sports Medicine.2024;[Epub] CrossRef
Resistin alleviates lipopolysaccharide-induced inflammation in bovine alveolar macrophages by activating the AMPK/mTOR signaling pathway and autophagy
Xiaoping Ma, Aining Yang, Xiaoben Fan, Hong Liu, Yu Gu, Zhisheng Wang, Hongrui Guo, Jing Fang, Hengmin Cui, Liping Gou, Junliang Deng, Dongjie Cai, Zhicai Zuo
Heliyon.2024; 10(19): e38026. CrossRef
Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration
Mohammad El-Nablaway, Fatema Rashed, Ehab S. Taher, Ahmed Abdeen, Noha Taymour, Magdalen M. Soliman, Hany K. Shalaby, Liana Fericean, Bănățean-Dunea Ioan, Mohamed El-Sherbiny, Elturabi Ebrahim, Afaf Abdelkader, Mohamed Abdo, Cucui-Cozma Alexandru, Gamal A
Frontiers in Bioengineering and Biotechnology.2024;[Epub] CrossRef
Exercise training to preserve vitality capacity in ageing
Raymond Jones, Taylor L. Taylor, Robert T. Mankowski, Fitzgerald Dodds, Michael Hankes, Joanna Hobson, Yi Lin, Keith Saffold, Silvienne C. Sint Jago, McKenna A. Tharpe, Emily L. Zumbro, Anna Thalacker‐Mercer, Thomas W. Buford
Experimental Physiology.2024;[Epub] CrossRef
The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model
Arafat Hassan Razon, Md. Alauddin, Nisat Farzana, Sanaullah Mazumdar, Md. Ruhul Amin, Md. Mahedi Hassan Tusher, Md. Asrafuzzaman, Nahid Hasan, Mahfuzur Rahman, Muhammad Saiedullah, Begum Rokeya, Md. Omar Faruque, Eusebio Chiefari
Journal of Diabetes Research.2024;[Epub] CrossRef
Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy
Krish Chandrasekaran, Joungil Choi, Mohammad Salimian, Ahmad F. Hedayat, James W. Russell
International Journal of Molecular Sciences.2024; 26(1): 80. CrossRef
Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study
Daiahun Thabah, Donkupar Syiem, Careen Liza Pakyntein, Sagnik Banerjee, Cynthia Erica Kharshiing, Atanu Bhattacharjee
Archives of Physiology and Biochemistry.2023; 129(5): 1071. CrossRef
The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review
Eren Canbolat, Funda Pınar Cakıroglu
Critical Reviews in Food Science and Nutrition.2023; 63(4): 449. CrossRef
Hydrogen Sulfide Regulates Glucose Uptake in Skeletal Muscles via S-Sulfhydration of AMPK in Muscle Fiber Type-Dependent Way
Kelin Li, Minghui Wang, Ruxia Wang, Xiaojuan Wang, Hongchao Jiao, Jingpeng Zhao, Yunlei Zhou, Haifang Li, Hai Lin
The Journal of Nutrition.2023; 153(10): 2878. CrossRef
Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
Ishitha Reddy, Yamini Yadav, Chinmoy Sankar Dey
Cellular and Molecular Neurobiology.2023; 43(4): 1551. CrossRef
Gene expression profile analysis unravelled the systems level association of renal cell carcinoma with diabetic nephropathy and Matrix-metalloproteinase-9 as a potential therapeutic target
Aditya Rao, Pavan Gollapalli, Nandini Prasad Shetty
Journal of Biomolecular Structure and Dynamics.2023; 41(16): 7535. CrossRef
Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
Ha-Thanh-Tung Pham, Eun-Jin Park, Byeol Ryu, Hee-Ju Lee, Thi-Phuong Doan, Hyo-Moon Cho, Thi-Linh-Giang Pham, Won-Keun Oh
Phytochemistry.2023; 205: 113513. CrossRef
The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB–mediated inflammatory response
Jingjing Liu, Jiao Lu, Liumei Zhang, Yuting Liu, Yuan Zhang, Yaran Gao, Xinmeng Yuan, Mengqi Xiang, Qiang Tang
Biomedicine & Pharmacotherapy.2023; 157: 114080. CrossRef
Recent advances in sea cucumber peptide: Production, bioactive properties, and prospects
Jiacong Man, A. M. Abd El‐Aty, Zuzhe Wang, Mingqian Tan
Food Frontiers.2023; 4(1): 131. CrossRef
Betulinic Acid: Triterpenoid Derivative Induced NADPH-d Expression in the Urinary System with a Possible Renal Protective Role of Nitric Oxide
Soo Yue Yin, Siddiqua Ayesha, Chellasamy Panneerselvam, Adel Ibrahim Alalawy, Fahad Mohamed Almutairi, Mohamed Ali Seyed
Drugs and Drug Candidates.2023; 2(1): 52. CrossRef
Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review
Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou, Baoan Chen
Biomolecules.2023; 13(2): 250. CrossRef
The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
Nutrients.2023; 15(7): 1660. CrossRef
Modulation of GPC-4 and GPLD1 serum levels by improving glycemic indices in type 2 diabetes: Resistance training and hawthorn extract intervention
Ali Heidarianpour, Maryam Keshvari, Siamak Shahidi, Mohammad Zarei
Heliyon.2023; 9(4): e15537. CrossRef
Oral administration of wild plant‐derived minerals and red ginseng ameliorates insulin resistance in fish through different pathways
Kiyomi Takase, Izuru Kakuta
Physiological Reports.2023;[Epub] CrossRef
Anti‐fatigue properties of the ethanol extract of Moringa oleifera leaves in mice
Xiangyu Bian, Yawen Wang, Renren Yang, Yuying Ma, Weiyun Dong, Changjiang Guo, Weina Gao
Journal of the Science of Food and Agriculture.2023; 103(11): 5500. CrossRef
AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis
Ankita Sharma, Sumit Kr Anand, Neha Singh, Upendra Nath Dwivedi, Poonam Kakkar
Experimental Cell Research.2023; 428(1): 113614. CrossRef
Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells
Caizhu Wang, Ruqin Lin, Xueying Qi, Qiang Xu, Xingsheng Sun, Yurong Zhao, Tianqing Jiang, Jun Jiang, Yu Sun, Yiqun Deng, Jikai Wen
Biochemical Pharmacology.2023; 214: 115645. CrossRef
Gαi‐coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals
Do‐Hyung Lee, Kyung‐Sun Heo, Chang‐Seon Myung
Obesity.2023; 31(7): 1871. CrossRef
Sapogeninas de Chenopodium quinoa Willd como activadores potenciales de AMPKβ2 para la homeostasis independiente de insulina
Ricardo Enrique Grados Torrez, Dayana Pamela Bello- Kopa, Ricardo Enrique Grados-Torrez
Gaceta Médica Boliviana.2023; 46(1): 6. CrossRef
Potential mechanisms of multimodal prehabilitation effects on surgical complications: a narrative review
Daniel Sibley, Maggie Chen, Malcolm A West, Andrew G Matthew, Daniel Santa Mina, Ian Randall
Applied Physiology, Nutrition, and Metabolism.2023; 48(9): 639. CrossRef
Insights into the molecular mechanism of muscle textural quality improvement treated by exercise using comparative transcriptome analysis on the hybrid (Erythroculter ilishaeformis ♀ × Ancherythroculter nigrocauda ♂)
Lang Zhang, Huijie Wei, Yali Yu, Qing Li, Ziwei Song, Yanhong Sun, Pei Li, Jian Chen, Jinhua Gan, Hui Zhang, Xiaorong Lu, Guiying Wang, Li He
Aquaculture Reports.2023; 31: 101672. CrossRef
Nrf2 modulates the benefits of evening exercise in type 2 diabetes
Babatunde Fasipe, Ismail Laher
Sports Medicine and Health Science.2023; 5(4): 251. CrossRef
Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats
Douglas Lopes Almeida, Gabriel Sergio Fabricio, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Camila Cristina Ianoni Matiusso, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Audrei Pavanello, Ananda Malta, Kesia Palma-Rigo, Paulo Cezar de F
Journal of Developmental Origins of Health and Disease.2022; 13(3): 406. CrossRef
Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function
Xue Wang, Yu-ting Zhu, Yi Zhu, Yan-ling Sun, Jun Huang, Zhe Li, Yan Wang, Jun-chao Wu, Zheng-hong Qin, Fang Lin
Acta Pharmacologica Sinica.2022; 43(4): 850. CrossRef
The Molecular Signature of High-intensity Training in the Human Body
Patrick Wahl, Wilhelm Bloch, Sebastian Proschinger
International Journal of Sports Medicine.2022; 43(03): 195. CrossRef
Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin
Xiaowei Yang, Qi Lai, Xinmin Yang, Banglin Xie, Bin Zhang, Xiaoyong Zhang, Yen Wei
Materials Chemistry Frontiers.2022; 6(2): 128. CrossRef
Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisic
International Journal of Molecular Sciences.2022; 23(1): 548. CrossRef
The Effect of Various Training on the Expression of the 5’amp-Activated Protein Kinase Α2 and Glucose Transporter - 4 in Type-2 Diabetes Mellitus Rat
Rahmi Rahmi, Yetty Machrina, Zulham Yamamoto
Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 1. CrossRef
Avian Orexin: Feed Intake Regulator or Something Else?
Alison Ramser, Sami Dridi
Veterinary Sciences.2022; 9(3): 112. CrossRef
Luteolin Synergistically Enhances Antitumor Activity of Oxaliplatin in Colorectal Carcinoma via AMPK Inhibition
Chan Ho Jang, Nayoung Moon, Jinkyung Lee, Min Jeong Kwon, Jisun Oh, Jong-Sang Kim
Antioxidants.2022; 11(4): 626. CrossRef
Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity
Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
Frontiers in Physiology.2022;[Epub] CrossRef
Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition
Jinsoo Kim, Jinyoung Son, Dohee Ahn, Gibeom Nam, Xiaodi Zhao, Hyuna Park, Woojoo Jeong, Sang J. Chung
International Journal of Molecular Sciences.2022; 23(7): 3927. CrossRef
Effect of Long-Term Supplementation with Acetic Acid on the Skeletal Muscle of Aging Sprague Dawley Rats
Hitomi Maruta, Reina Abe, Hiromi Yamashita
International Journal of Molecular Sciences.2022; 23(9): 4691. CrossRef
AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway
Vishal Kothari, Jeganathan Ramesh Babu, Suresh T. Mathews, Regis Moreau
PLOS ONE.2022; 17(5): e0266472. CrossRef
Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling
Md Badrul Alam, Jeong‐Sic Ra, Ji‐Young Lim, Bo‐Rim Song, Ahsan Javed, Sang‐Han Lee
Molecular Nutrition & Food Research.2022;[Epub] CrossRef
Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome
Tara McDonnell, Leanne Cussen, Marie McIlroy, Michael W. O’Reilly
Therapeutic Advances in Endocrinology and Metabolism.2022;[Epub] CrossRef
Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats
Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu
Food Science and Human Wellness.2022; 11(6): 1614. CrossRef
Hernandezine, a natural herbal alkaloid, ameliorates type 2 diabetes by activating AMPK in two mouse models
Jing Bai, Shuai Zhang, Jinjing Cao, Hongbin Sun, Zhiguo Mang, Wei L. Shen, Hao Li
Phytomedicine.2022; 105: 154366. CrossRef
N-Octyl Caffeamide, a Caffeic Acid Amide Derivative, Prevents Progression of Diabetes and Hepatic Steatosis in High-Fat Diet Induced Obese Mice
Miao-Yi Wu, Chia-Chu Liu, Su-Chu Lee, Yueh-Hsiung Kuo, Tusty-Jiuan Hsieh
International Journal of Molecular Sciences.2022; 23(16): 8948. CrossRef
The Potential Therapeutic Role of Metformin in Diabetic and Non-Diabetic Bone Impairment
Wei Mu, Guoqiang Liang, Yue Feng, Yunyun Jiang, Falin Qu
Pharmaceuticals.2022; 15(10): 1274. CrossRef
Characteristics of the Protocols Used in Electrical Pulse Stimulation of Cultured Cells for Mimicking In Vivo Exercise: A Systematic Review, Meta-Analysis, and Meta-Regression
Eleni Nintou, Eleni Karligiotou, Maria Vliora, Leonidas G. Ioannou, Andreas D. Flouris
International Journal of Molecular Sciences.2022; 23(21): 13446. CrossRef
Heliciopsides A−E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake
Byeol Ryu, Eun-Jin Park, Thi-Phuong Doan, Hyo-Moon Cho, Jin-Pyo An, Thi-Linh-Giang Pham, Ha-Thanh-Tung Pham, Won-Keun Oh
Pharmaceuticals.2022; 15(11): 1315. CrossRef
Why are physical activity breaks more effective than a single session of isoenergetic exercise in reducing postprandial glucose? A systemic review and meta-analysis
Hannah Gouldrup, Tongyu Ma
Journal of Sports Sciences.2021; 39(2): 212. CrossRef
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation
Hee-Seon Park, Ji-Won Song, Jin-Ho Park, Byung-Kwan Lim, Og-Sung Moon, Hwa-Young Son, Jae-Hyuk Lee, Bin Gao, Young-Suk Won, Hyo-Jung Kwon
Autophagy.2021; 17(9): 2549. CrossRef
Dissecting the molecular pathways involved in the effects of physical activity on breast cancers cells: A narrative review
Francesca Maria Orlandella, Anna Elisa De Stefano, Paola Lucia Chiara Iervolino, Pasqualina Buono, Andrea Soricelli, Giuliana Salvatore
Life Sciences.2021; 265: 118790. CrossRef
In silico study to quantify the effect of exercise on surface GLUT4 translocation in diabetes management
Darshna M. Joshi, Jignesh Patel, Hardik Bhatt
Network Modeling Analysis in Health Informatics and Bioinformatics.2021;[Epub] CrossRef
Rationale for the use of metformin and exercise to counteract statin‐associated side effects
Jonida Haxhi, Paul D. Thompson
International Journal of Clinical Practice.2021;[Epub] CrossRef
Effects of long-term taurine supplementation on age-related changes in skeletal muscle function of Sprague–Dawley rats
Yun Ma, Hitomi Maruta, Baojun Sun, Chengduo Wang, Chiaki Isono, Hiromi Yamashita
Amino Acids.2021; 53(2): 159. CrossRef
The Effect of Swimming Training and Cinnamon Consumption on the Gene Expression of GLUT4 and Insulin Receptor in the Brown Adipose Tissue of Diabetic Rats
Mojtaba Karimi Fard, Ali Khajehlandi, Amin Mohammadi
Gene, Cell and Tissue.2021;[Epub] CrossRef
Antiobesity effect of Brassica juncea cultivated in Jeongseon with optimized sinigrin content using 3T3‐L1 adipocytes
Hee‐Yeon Kwon, Sun‐Il Choi, Xionggao Han, Xiao Men, Gill‐Woong Jang, Ye‐Eun Choi, Ok‐Hwan Lee
Journal of Food Biochemistry.2021;[Epub] CrossRef
Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel
Yuan Guan, Hefei Sun, Huiying Chen, Peijun Li, Yang Shan, Xia Li
Food & Function.2021; 12(9): 4221. CrossRef
Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle
Ji H. Kang, Ji E. Park, Jason Dagoon, Stewart W. C. Masson, Troy L. Merry, Shannon N. Bremner, Jessica R. Dent, Simon Schenk
Journal of Applied Physiology.2021; 130(6): 1893. CrossRef
TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells
Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
Cells.2021; 10(6): 1560. CrossRef
Effects of exercise on cellular and tissue aging
Priscila Viana Carapeto, Cristina Aguayo-Mazzucato
Aging.2021; 13(10): 14522. CrossRef
Biglycan reduces body weight by regulating food intake in mice and improves glucose metabolism through AMPK/AKT dual pathways in skeletal muscle
InHyeok Chung, Shin Ae Kim, Seolsong Kim, Jung Ok Lee, Clara Yongjoo Park, Juhee Lee, Jun Kang, Jin Young Lee, Ilhyeok Seo, Hye Jeong Lee, Jeong Ah Han, Min Ju Kang, Eunice Lim, Su Jin Kim, Sang Woo Wu, Joo Yeon Oh, Ji Hyung Chung, Eun‐Kyoung Kim, Hyeon S
The FASEB Journal.2021;[Epub] CrossRef
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
Ibrahim Mohammed, Morley D. Hollenberg, Hong Ding, Chris R. Triggle
Frontiers in Endocrinology.2021;[Epub] CrossRef
The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever
Fred J. DiMenna, Avigdor D. Arad
Cardiovascular Endocrinology & Metabolism.2021; 10(3): 149. CrossRef
Comparative analyses of liver transcriptomes reveal the effect of exercise on growth-, glucose metabolism-, and oxygen transport-related genes and signaling pathways in grass carp (Ctenopharyngodon idella)
Lang Zhang, Xiaohui Li, Yali Yu, Lin Zhang, Lixue Dong, Jinhua Gan, Tao Mao, Ting Liu, Jie Peng, Li He
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2021; 262: 111081. CrossRef
Effects of moderate exercise on hepatic amino acid and fatty acid composition, liver transcriptome, and intestinal microbiota in channel catfish (Ictalurus punctatus)
Lang Zhang, Yali Yu, Lixue Dong, Jinhua Gan, Tao Mao, Ting Liu, Xiaohui Li, Li He
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics.2021; 40: 100921. CrossRef
Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ
Sih-Pei Chen, Shian-Ren Lin, Ting-Hsu Chen, Hui-Suan Ng, Hip-Seng Yim, Max K. Leong, Ching-Feng Weng
Biomedicine & Pharmacotherapy.2021; 144: 112333. CrossRef
The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells
Lakshi A. Dayarathne, Sachithra S. Ranaweera, Premkumar Natraj, Priyanka Rajan, Young Jae Lee, Chang-Hoon Han
Journal of Veterinary Science.2021;[Epub] CrossRef
Inhibition of Digestive Enzyme and Stimulation of Human Liver Cells (HepG2) Glucose Uptake by Date Seeds Extract
Hira Shakoor, Fatima Abdelfattah, Khaula Albadi, Mentalla Adib, Jaleel Kizhakkayil, Carine Platat, Armando Zarrelli
Evidence-Based Complementary and Alternative Medicine.2020;[Epub] CrossRef
Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin
Saman Bahrambeigi, Vahid Shafiei-Irannejad
Biochemical Pharmacology.2020; 174: 113787. CrossRef
Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle
Sung Sup Park, Young-Kyo Seo
International Journal of Molecular Sciences.2020; 21(6): 1949. CrossRef
Regulation of podocytes function by AMP-activated protein kinase
Dorota Rogacka, Irena Audzeyenka, Agnieszka Piwkowska
Archives of Biochemistry and Biophysics.2020; 692: 108541. CrossRef
AMPK'nin Biyokimyası: Etki Mekanizmaları ve Diyabetin Tedavisindeki Önemi
Cemalettin KİSMİROĞLU, Serdar CENGİZ, Mustafa YAMAN
European Journal of Science and Technology.2020; : 162. CrossRef
Potent Inhibitory Effect of BJ-3105, a 6-Alkoxypyridin-3-ol Derivative, on Murine Colitis Is Mediated by Activating AMPK and Inhibiting NOX
Pallavi Gurung, Sadan Dahal, Prakash Chaudhary, Diwakar Guragain, Ujjwala Karmacharya, Jung-Ae Kim, Byeong-Seon Jeong
International Journal of Molecular Sciences.2020; 21(9): 3145. CrossRef
Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in skeletal muscle
Wai-Kin So, Hyoung Kyu Kim, Yingxian Chen, Seung Hun Jeong, Patrick Ka Kit Yeung, Billy C. K. Chow, Jin Han, Sookja K. Chung
Pflügers Archiv - European Journal of Physiology.2020; 472(2): 195. CrossRef
Metformin ameliorates animal models of dermatitis
Soo Young Choi, Chanmi Lee, Min-Jeong Heo, Yeong Min Choi, In-sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung
Inflammopharmacology.2020; 28(5): 1293. CrossRef
Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators
Junwei Wang, Junhua Liu, Zhifu Xie, Jia Li, Jingya Li, Lihong Hu
Bioorganic & Medicinal Chemistry Letters.2020; 30(2): 126790. CrossRef
The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
Jung Ok Lee, Won Seok Byun, Min Ju Kang, Jeong Ah Han, Jiyoung Moon, Min‐Jeong Shin, Ho Jun Lee, Ji Hyung Chung, Jin‐Seok Lee, Chang‐Gue Son, Kwon‐Ho Song, Tae Woo Kim, Eun‐Soo Lee, Hong Min Kim, Choon Hee Chung, Kevin R. W. Ngoei, Naomi X. Y. Ling, Jonat
The FEBS Journal.2020; 287(10): 2087. CrossRef
Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes
Khanyisani Ziqubu, Christo J. F. Muller, Phiwayinkosi V. Dludla, Sinenhlanhla X. H. Mthembu, Nnini Obonye, Johan Louw, Abidemi P. Kappo, Sonia Silvestri, Patrick Orlando, Luca Tiano, Sithandiwe E. Mazibuko-Mbeje
Molecules.2020; 25(8): 1773. CrossRef
Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner
Dong-Yeon Kim, Su-Geun Lim, Kyoungho Suk, Won-Ha Lee
Biochemistry and Cell Biology.2020; 98(2): 137. CrossRef
cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells
Toshio Norikura, Shiori Kajiya, Mami Sugawara, Miwa Kubo, Yoshiyasu Fukuyama, Shin Sato
Journal of Functional Foods.2020; 64: 103632. CrossRef
Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice
Florian Juszczak, Maud Vlassembrouck, Olivia Botton, Thomas Zwakhals, Morgane Decarnoncle, Alexandra Tassin, Nathalie Caron, Anne-Emilie Declèves
International Journal of Molecular Sciences.2020; 22(1): 350. CrossRef
The Regulation of Fat Metabolism during Aerobic Exercise
Antonella Muscella, Erika Stefàno, Paola Lunetti, Loredana Capobianco, Santo Marsigliante
Biomolecules.2020; 10(12): 1699. CrossRef
Chronic neuromuscular electrical stimulation improves muscle mass and insulin sensitivity in a mouse model
Adiel Lotri-Koffi, Marion Pauly, Emeline Lemarié, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pépin, Isabelle Vivodtzev
Scientific Reports.2019;[Epub] CrossRef
Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer
Kyuwan Lee, Debu Tripathy, Wendy Demark-Wahnefried, Kerry S. Courneya, Nathalie Sami, Leslie Bernstein, Darcy Spicer, Thomas A. Buchanan, Joanne E. Mortimer, Christina M. Dieli-Conwright
JAMA Oncology.2019; 5(5): 710. CrossRef
Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
Jiyoung Moon, Min Jin Ha, Min-Jeong Shin, Oh Yoen Kim, Eun Hye Yoo, Juhyun Song, Ji Hyung Chung
Nutrients.2019; 11(12): 3035. CrossRef
Anthraquinone-type inhibitor of α-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes
Md Badrul Alam, Vivek K. Bajpai, Jeong-Sic Ra, Ji-Young Lim, Hongyan An, Shruti Shukla, Khong Trong Quan, Imran Khan, Yun Suk Huh, Young-Kyu Han, MinKyun Na, Sang-Han Lee
Food and Chemical Toxicology.2019; 129: 337. CrossRef
AMPKα2 Deficiency Does Not Affect the Exercise-Induced Improvements in Glucose Tolerance and Metabolic Disorders in Mice Fed a High-Fat Diet
Zhong-Guang SUN, Ge TIAN, Xiao-Ci ZHENG, Wen-Ying LIU, Xue-Ting LUO, Jing XIAO, Hui SONG, Xin XU
Journal of Nutritional Science and Vitaminology.2019; 65(6): 491. CrossRef
Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals
Sanghee Park, Kristen D. Turner, Donghai Zheng, Jeffrey J. Brault, Kai Zou, Alec B. Chaves, Thomas S. Nielsen, Charles J. Tanner, Jonas T. Treebak, Joseph A. Houmard
The Journal of Physiology.2019; 597(2): 449. CrossRef
Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics
Eric Francelino Andrade, Víviam de Oliveira Silva, Débora Ribeiro Orlando, Luciano José Pereira
Current Diabetes Reviews.2019; 15(2): 105. CrossRef
Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway
Nami Kim, Mi Sun Kang, Miso Nam, Shin Ae Kim, Geum-Sook Hwang, Hyeon Soo Kim
International Journal of Molecular Sciences.2019; 20(19): 4751. CrossRef
Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats
Jeong Rim Ko, Dae Yun Seo, Tae Nyun Kim, Se Hwan Park, Hyo-Bum Kwak, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
Journal of Clinical Medicine.2019; 8(5): 666. CrossRef
Metformin; an old antidiabetic drug with new potentials in bone disorders
Saman Bahrambeigi, Bahman Yousefi, Mahdi Rahimi, Vahid Shafiei-Irannejad
Biomedicine & Pharmacotherapy.2019; 109: 1593. CrossRef
A comparative analysis of various flavonoids in the regulation of obesity and diabetes: An in vitro and in vivo study
Ritu Varshney, Rutusmita Mishra, Neeladrisingha Das, Debabrata Sircar, Partha Roy
Journal of Functional Foods.2019; 59: 194. CrossRef
Akt activation: A potential strategy to ameliorate insulin resistance
Zhengyi Zhang, Huadong Liu, Jiankang Liu
Diabetes Research and Clinical Practice.2019; 156: 107092. CrossRef
Chitosan encapsulated nanocurcumin induces GLUT-4 translocation and exhibits enhanced anti-hyperglycemic function
Pratibha Chauhan, Akhilesh Kumar Tamrakar, Sunil Mahajan, G.B.K.S. Prasad
Life Sciences.2018; 213: 226. CrossRef
Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity
Victor Castro, Marta Skowronska, Jorge Lombardi, Jane He, Neil Seth, Martina Velichkovska, Michal Toborek
Journal of Cerebral Blood Flow & Metabolism.2018; 38(2): 317. CrossRef
Interactions between dietary carbohydrate and metformin: Implications on energy sensing, insulin signaling pathway, glycolipid metabolism and glucose tolerance in blunt snout bream Megalobrama amblycephala
Chao Xu, Wen-Bin Liu, Ding-Dong Zhang, Xiu-Fei Cao, Hua-Juan Shi, Xiang-Fei Li
Aquaculture.2018; 483: 183. CrossRef
Gossypol from Cottonseeds Ameliorates Glucose Uptake by Mimicking Insulin Signaling and Improves Glucose Homeostasis in Mice with Streptozotocin‐Induced Diabetes
Md Badrul Alam, Hongyan An, Jeong-Sic Ra, Ji-young Lim, Seung-Hyun Lee, Chi-Yeol Yoo, Sang-Han Lee, Mohamed M. Abdel-Daim
Oxidative Medicine and Cellular Longevity.2018;[Epub] CrossRef
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist, Madelene Ericsson, Björn Eriksson, Kajsa Linde, Jacob Westman, Thomas Edlund, Helena Edlund
JCI Insight.2018;[Epub] CrossRef
Aerobic exercise training decreases cereblon and increases AMPK signaling in the skeletal muscle of STZ-induced diabetic rats
Jeong Rim Ko, Dae Yun Seo, Se Hwan Park, Hyo Bum Kwak, Min Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
Biochemical and Biophysical Research Communications.2018; 501(2): 448. CrossRef
AMPK in skeletal muscle function and metabolism
Rasmus Kjøbsted, Janne R. Hingst, Joachim Fentz, Marc Foretz, Maria‐Nieves Sanz, Christian Pehmøller, Michael Shum, André Marette, Remi Mounier, Jonas T. Treebak, Jørgen F. P. Wojtaszewski, Benoit Viollet, Louise Lantier
The FASEB Journal.2018; 32(4): 1741. CrossRef
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins
Tianyi Wang, Yanmei Niu, Sujuan Liu, Hairui Yuan, Xiaolei Liu, Li Fu
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(10): 3368. CrossRef
Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury
Peng Wang, Lizhu Jiang, Nian Zhou, Hao Zhou, Huzhe Liu, Wenrui Zhao, Hanxiang Zhang, Xiang Zhang, Zhenming Hu
Oncotarget.2018; 9(9): 8427. CrossRef
Cocoa Flavanol Supplementation and Exercise: A Systematic Review
Lieselot Decroix, Danusa Dias Soares, Romain Meeusen, Elsa Heyman, Cajsa Tonoli
Sports Medicine.2018; 48(4): 867. CrossRef
Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes
Hojun Lee, Wook Song
Journal of Obesity & Metabolic Syndrome.2018; 27(3): 150. CrossRef
Vernonia cinerea water extract improves insulin resistance in high-fat diet–induced obese mice
Jarinyaporn Naowaboot, Supaporn Wannasiri, Patchareewan Pannangpetch
Nutrition Research.2018; 56: 51. CrossRef
Cell-Specific “Competition for Calories” Drives Asymmetric Nutrient-Energy Partitioning, Obesity, and Metabolic Diseases in Human and Non-human Animals
Edward Archer, Gregory Pavela, Samantha McDonald, Carl J. Lavie, James O. Hill
Frontiers in Physiology.2018;[Epub] CrossRef
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
Baile Wang, Kenneth King-Yip Cheng
International Journal of Molecular Sciences.2018; 19(11): 3552. CrossRef
Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
Danqing Feng, Tesfaye Biftu, F. Anthony Romero, Ahmet Kekec, James Dropinski, Andrew Kassick, Shiyao Xu, Marc M. Kurtz, Anantha Gollapudi, Qing Shao, Xiaodong Yang, Ku Lu, Gaochao Zhou, Daniel Kemp, Robert W. Myers, Hong-Ping Guan, Maria E. Trujillo, Cai
ACS Medicinal Chemistry Letters.2018; 9(1): 39. CrossRef
2-Bromo-4′-methoxychalcone and 2-Iodo-4′-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5′-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice
Chi-Ting Hsieh, Fang-Rong Chang, Yi-Hong Tsai, Yang-Chang Wu, Tusty-Jiuan Hsieh
International Journal of Molecular Sciences.2018; 19(9): 2763. CrossRef
Dynamic transcriptomic analysis in hircine longissimus dorsi muscle from fetal to neonatal development stages
Siyuan Zhan, Wei Zhao, Tianzeng Song, Yao Dong, Jiazhong Guo, Jiaxue Cao, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang
Functional & Integrative Genomics.2018; 18(1): 43. CrossRef
Oyster mushroom functions as an anti-hyperglycaemic through phosphorylation of AMPK and increased expression of GLUT4 in type 2 diabetic model rats
Mohammad Asrafuzzaman, Mohammad M. Rahman, Manoj Mandal, Mohammad Marjuque, Amrita Bhowmik, Begum Rokeya, Zahid Hassan, Mohammad Omar Faruque
Journal of Taibah University Medical Sciences.2018; 13(5): 465. CrossRef
AMP-activated protein kinase α1 in Megalobrama amblycephala: Molecular characterization and the transcriptional modulation by nutrient restriction and glucose and insulin loadings
Chao Xu, Xiang-Fei Li, Hua-Juan Shi, Jie Liu, Li Zhang, Wen-Bin Liu
General and Comparative Endocrinology.2018; 267: 66. CrossRef
Comprehensive Relevance of AMPK in Adaptive Responses of Physical Exercise, Skeletal Muscle and Neuromuscular Disorders
Jun-Ho Lee
Journal of The Korean Society of Physical Medicine.2018; 13(3): 141. CrossRef
Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism
Natalie R. Janzen, Jamie Whitfield, Nolan J. Hoffman
International Journal of Molecular Sciences.2018; 19(11): 3344. CrossRef
Exercising with blocked muscle glycogenolysis: Adaptation in the McArdle mouse
Tue L. Nielsen, Tomàs Pinós, Astrid Brull, John Vissing, Thomas O. Krag
Molecular Genetics and Metabolism.2018; 123(1): 21. CrossRef
Pharmacological Activities of Mogrosides
Can Liu, Longhai Dai, Yueping Liu, Dequan Dou, Yuanxia Sun, Lanqing Ma
Future Medicinal Chemistry.2018; 10(8): 845. CrossRef
Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4
Kevin R.W. Ngoei, Christopher G. Langendorf, Naomi X.Y. Ling, Ashfaqul Hoque, Swapna Varghese, Michelle A. Camerino, Scott R. Walker, Ylva E. Bozikis, Toby A. Dite, Ashley J. Ovens, William J. Smiles, Roxane Jacobs, He Huang, Michael W. Parker, John W. Sc
Cell Chemical Biology.2018; 25(6): 728. CrossRef
Fiber type-specific analysis of AMPK isoforms in human skeletal muscle: advancement in methods via capillary nanoimmunoassay
Irene S. Tobias, Kara K. Lazauskas, Jose A. Arevalo, James R. Bagley, Lee E. Brown, Andrew J. Galpin
Journal of Applied Physiology.2018; 124(4): 840. CrossRef
Insulin Mimetic Activity of 3,4-Seco and Hexanordammarane Triterpenoids Isolated from Gynostemma longipes
Ha Thanh Tung Pham, Thi Kim Quy Ha, Hyo Moon Cho, Ba Wool Lee, Jin Pyo An, Van On Tran, Won Keun Oh
Journal of Natural Products.2018; 81(11): 2470. CrossRef
Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism
A.D. Booth, A.M. Magnuson, J. Fouts, Y. Wei, D. Wang, M.J. Pagliassotti, M.T. Foster
Adipocyte.2018; 7(4): 261. CrossRef
Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase
Kasandra S. Hunter, Stephen J. Davies
Frontiers in Immunology.2018;[Epub] CrossRef
Neurogenic obesity and systemic inflammation following spinal cord injury: A review
Gary J. Farkas, David R. Gater
The Journal of Spinal Cord Medicine.2018; 41(4): 378. CrossRef
In Defense of Sugar: A Critique of Diet-Centrism
Edward Archer
Progress in Cardiovascular Diseases.2018; 61(1): 10. CrossRef
Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation
Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand, Lars Rönnbäck
Journal of Neuroinflammation.2018;[Epub] CrossRef
Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin‐Induced Diabetic Mice
Joo‐Hui Han, Nguyen Quoc Tuan, Min‐Ho Park, Khong Trong Quan, Joonseok Oh, Kyung‐Sun Heo, MinKyun Na, Chang‐Seon Myung
Molecular Nutrition & Food Research.2018;[Epub] CrossRef
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Robert W. Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M. Kurtz, Maria Trujillo, Dinko Gonzalez Trotter, Danqing Feng, Shiyao Xu, George Eiermann, Marie A. Holahan, Daniel Rubins, Stacey C
Science.2017; 357(6350): 507. CrossRef
Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: A portrait of molecular crosstalk
Mohammad Adil, Mohd Nizam Mansoori, Divya Singh, Amit Dattatraya Kandhare, Manju Sharma
Biomedicine & Pharmacotherapy.2017; 94: 1010. CrossRef
Rb2 inhibits α-glucosidase and regulates glucose metabolism by activating AMPK pathways in HepG2 cells
Hui Teng, Lei Chen, Ting Fang, Benyao Yuan, Qiyang Lin
Journal of Functional Foods.2017; 28: 306. CrossRef
The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury
Bing F. Wang, Jun Yoshioka
Journal of Cardiovascular Pharmacology and Therapeutics.2017; 22(3): 219. CrossRef
Efectos del ejercicio físico en los factores de riesgo cardiovascular que constituyen el síndrome metabólico: una alternativa para reducir su tendencia
Adrián Hernández Alonso
Revista Colombiana de Médicina Física y Rehabilitación.2017; 27(2): 140. CrossRef
Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells
Nami Kim, Miso Nam, Mi Sun Kang, Jung Ok Lee, Yong Woo Lee, Geum-Sook Hwang, Hyeon Soo Kim
Scientific Reports.2017;[Epub] CrossRef
Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
Prasenjit Manna, Arunkumar E. Achari, Sushil K. Jain
Archives of Biochemistry and Biophysics.2017; 615: 22. CrossRef
Care of the Athlete With Type 1 Diabetes Mellitus: A Clinical Review
William B. Horton, Jose S. Subauste
International Journal of Endocrinology and Metabolism.2016;[Epub] CrossRef
Cheonggukjang, a soybean paste fermented with B. licheniformis-67 prevents weight gain and improves glycemic control in high fat diet induced obese mice
Joo-Hee Choi, P.B.Tirupathi Pichiah, Min-Jung Kim, Youn-Soo Cha
Journal of Clinical Biochemistry and Nutrition.2016; 59(1): 31. CrossRef
Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes
Min Joo Kim, Young Do Koo, Min Kim, Soo Lim, Young Joo Park, Sung Soo Chung, Hak C. Jang, Kyong Soo Park
Diabetes & Metabolism Journal.2016; 40(5): 406. CrossRef
Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss
H.P. Vasantha Rupasinghe, Satvir Sekhon-Loodu, Theodora Mantso, Mihalis I. Panayiotidis
Pharmacology & Therapeutics.2016; 165: 153. CrossRef
Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise
Haiyan Wang, Naveen Sharma, Edward B. Arias, Gregory D. Cartee
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.2016; 71(3): 323. CrossRef
Acute resistance exercise-induced IGF1 expression and subsequent GLUT4 translocation
Kohei Kido, Satoru Ato, Takumi Yokokawa, Yuhei Makanae, Koji Sato, Satoshi Fujita
Physiological Reports.2016; 4(16): e12907. CrossRef
Regulation and function of AMPK in physiology and diseases
Sang-Min Jeon
Experimental & Molecular Medicine.2016; 48(7): e245. CrossRef
Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
Junjeong Choi, Ji-Hyun Lee, Ilkyoo Koh, Jin-Kyoung Shim, Junseong Park, Jeong Yong Jeon, Mijin Yun, Se Hoon Kim, Jong In Yook, Eui Hyun Kim, Jong Hee Chang, Sun Ho Kim, Yong Min Huh, Su Jae Lee, Michael Pollak, Pilnam Kim, Seok-Gu Kang, Jae-Ho Cheong
Oncotarget.2016; 7(40): 65643. CrossRef
[6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects
Jung Ok Lee, Nami Kim, Hye Jeong Lee, Ji Wook Moon, Soo Kyung Lee, Su Jin Kim, Joong Kwan Kim, Sun Hwa Park, Hyeon Soo Kim
Journal of Cellular Biochemistry.2015; 116(7): 1401. CrossRef
A glance at … exercise and glucose uptake
Michael J. Glade, Kyl Smith
Nutrition.2015; 31(6): 893. CrossRef
Exercising insulin sensitivity: AMPK turns on autophagy!
Yossi Dagon, Christos Mantzoros, Young-Bum Kim
Metabolism.2015; 64(6): 655. CrossRef
Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice
José M. Costa Júnior, Morgana R. Rosa, André O. Protzek, Flávia M. de Paula, Sandra M. Ferreira, Luiz F. Rezende, Emerielle C. Vanzela, Cláudio C. Zoppi, Leonardo R. Silveira, Isis C. Kettelhut, Antonio C. Boschero, Camila A. M. de Oliveira, Everardo M. C
Amino Acids.2015; 47(4): 745. CrossRef
Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells
Xiang-Yang Zhang, Tong-Tong Zhang, Dan-Dan Song, Jun- Hao Zhou, Rong Han, Zheng-Hong Qin, Rui Sheng
Molecular Brain.2015;[Epub] CrossRef
Identification of adenine modulating AMPK activation in NIH/3T3 cells by proteomic approach
Guang-Huar Young, Jiun-Tsai Lin, Yi-Fang Cheng, Chun-Fang Huang, Cheng-Yu Chao, Jing-Yi Nong, Po-Ku Chen, Han-Min Chen
Journal of Proteomics.2015; 120: 204. CrossRef
Mechanisms for independent and combined effects of calorie restriction and acute exercise on insulin-stimulated glucose uptake by skeletal muscle of old rats
Naveen Sharma, Haiyan Wang, Edward B. Arias, Carlos M. Castorena, Gregory D. Cartee
American Journal of Physiology-Endocrinology and Metabolism.2015; 308(7): E603. CrossRef
Human muscle fibre type‐specific regulation of AMPK and downstream targets by exercise
Dorte E. Kristensen, Peter H. Albers, Clara Prats, Otto Baba, Jesper B. Birk, Jørgen F. P. Wojtaszewski
The Journal of Physiology.2015; 593(8): 2053. CrossRef
Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK
Qun Huang, Lei Chen, Hui Teng, Hongbo Song, Xiaoqi Wu, Meiyu Xu
Journal of Functional Foods.2015; 19: 487. CrossRef
Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells
Mohamad Abu Bakar, Kian-Kai Cheng, Mohamad Sarmidi, Harisun Yaakob, Hasniza Huri
Molecules.2015; 20(5): 8242. CrossRef
Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance
Mark J. W. Hanssen, Roel Wierts, Joris Hoeks, Anne Gemmink, Boudewijn Brans, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
Diabetologia.2015; 58(3): 586. CrossRef
Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise
Hayley M. O'Neill, James S. Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J. Ford, Jason R. B. Dyck, Bryce J. van Denderen, Bruce E. Kemp, Gregory R. Steinberg
Physiological Reports.2015; 3(7): e12444. CrossRef
Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation
Sukriti Krishan, Des R. Richardson, Sumit Sahni
Molecular Pharmacology.2015; 87(3): 363. CrossRef
Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle
Takashi Sasaki, Rieko Nakata, Hiroyasu Inoue, Makoto Shimizu, Jun Inoue, Ryuichiro Sato
American Journal of Physiology-Endocrinology and Metabolism.2014; 306(9): E1085. CrossRef
A novel heterozygous mutation in the glucokinase gene conferring exercise-induced symptomatic hyperglycaemia responsive to sulfonylurea
M.S.E. Ebrahim, M.L. Lawson, M.T. Geraghty
Diabetes & Metabolism.2014; 40(4): 310. CrossRef
Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice
Kwon-Il Seo, Jin Lee, Ra-Yeong Choi, Hae-In Lee, Ju-Hye Lee, Yong-Ki Jeong, Myung-Joo Kim, Mi-Kyung Lee
Food & Function.2014; 5(7): 1579. CrossRef
The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions
M.F.P. Silvestre, B. Viollet, P.W. Caton, J. Leclerc, I. Sakakibara, M. Foretz, M.C. Holness, M.C. Sugden
Life Sciences.2014; 100(1): 55. CrossRef
Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation
Fan-Lun Liu, Jui-Ling Hsu, Yean-Jang Lee, Yu-Shun Dong, Fan-Lu Kung, Ching-Shih Chen, Jih-Hwa Guh
European Journal of Pharmacology.2014; 730: 90. CrossRef
Fighting obesity: When muscle meets fat
Xin Yang, Pengpeng Bi, Shihuan Kuang
Adipocyte.2014; 3(4): 280. CrossRef
Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway
Bo-Lin Chen, Li-Ting Wang, Kuo-How Huang, Ching-Chia Wang, Chih-Kang Chiang, Shing-Hwa Liu
The Journal of Nutritional Biochemistry.2014; 25(11): 1226. CrossRef
AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
Louise Lantier, Joachim Fentz, Rémi Mounier, Jocelyne Leclerc, Jonas T. Treebak, Christian Pehmøller, Nieves Sanz, Iori Sakakibara, Emmanuelle Saint‐Amand, Stéphanie Rimbaud, Pascal Maire, André Marette, Renée Ventura‐Clapier, Arnaud Ferry, Jørgen F. P. W
The FASEB Journal.2014; 28(7): 3211. CrossRef
Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity
Mario Ost, Franziska Werner, Janine Dokas, Susanne Klaus, Anja Voigt, Juergen Eckel
PLoS ONE.2014; 9(4): e94689. CrossRef
Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
Min-Jung Park, Dong-Il Kim, Seul-Ki Lim, Joo-Hee Choi, Jong-Choon Kim, Kyung-Chul Yoon, Jee-Bum Lee, Jae-Hyuk Lee, Ho-Jae Han, In-Pyo Choi, Hyoung-Chin Kim, Soo-Hyun Park
Journal of Hepatology.2014; 61(5): 1151. CrossRef
Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells
Zhu Li, Chang-Lin Ni, Zhi Yao, Li-Ming Chen, Wen-Yan Niu
Metabolism.2014; 63(8): 1022. CrossRef
Effects of metformin on weight loss
Steven K. Malin, Sangeeta R. Kashyap
Current Opinion in Endocrinology, Diabetes & Obesity.2014; 21(5): 323. CrossRef
Changes of Blood Glucose and Lactate Concentration in Body Wearing Firefighting Protective Equipments
Chang-Hoon Bang
Journal of Korean Society of Hazard Mitigation.2014; 14(1): 263. CrossRef
Exercise, Energy Intake, Glucose Homeostasis, and the Brain
Henriette van Praag, Monika Fleshner, Michael W. Schwartz, Mark P. Mattson
The Journal of Neuroscience.2014; 34(46): 15139. CrossRef
The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
Takuya Sakurai, Junetsu Ogasawara, Takako Kizaki, Shogo Sato, Yoshinaga Ishibashi, Motoko Takahashi, Osamu Kobayashi, Shuji Oh-ishi, Junichi Nagasawa, Kazuto Takahashi, Hitoshi Ishida, Tetsuya Izawa, Hideki Ohno
International Journal of Endocrinology.2013; 2013: 1. CrossRef
Flavonoids from Tetrastigma obtectum enhancing glucose consumption in insulin-resistance HepG2 cells via activating AMPK
Mei-Na Jin, Guo-Ru Shi, Sheng-An Tang, Nan-Qin, Wei Qiao, Hong-Quan Duan
Fitoterapia.2013; 90: 240. CrossRef
AMPK, insulin resistance, and the metabolic syndrome
Neil B. Ruderman, David Carling, Marc Prentki, José M. Cacicedo
Journal of Clinical Investigation.2013; 123(7): 2764. CrossRef
Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
Veronica Martinez Marignac, Sarah Smith, Nader Toban, Miguel Bazile, Raquel Aloyz
Oncotarget.2013; 4(12): 2550. CrossRef
Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats
Wenjuan Xing, Youyou Li, Haifeng Zhang, Chunjuan Mi, Zuoxu Hou, Michael J. Quon, Feng Gao
American Journal of Physiology-Heart and Circulatory Physiology.2013; 305(8): H1111. CrossRef
AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma
Chin-Jung Hsu, Min-Huan Wu, Chin-Yuan Chen, Chun-Hao Tsai, Horng-Chaung Hsu, Chih-Hsin Tang
Cell Communication and Signaling.2013;[Epub] CrossRef

Original Articles

Effects of Aerobic Exercise Intensity on Abdominal and Thigh Adipose Tissue and Skeletal Muscle Attenuation in Overweight Women with Type 2 Diabetes Mellitus: Ji Yeon Jung, Kyung Ah Han, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min; Diabetes Metab J. 2012;36(3):211-221. Published online June 14, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.3.211

9,004 View
53 Download
26 Crossref

Abstract PDF PubReader ePub

Background

We investigated the effects of exercise intensity on abdominal and mid-thigh adipose tissue, attenuation of skeletal muscle, and insulin sensitivity in overweight women with type 2 diabetes mellitus (T2DM).

Methods

Twenty-eight patients were randomly assigned to control (CG, n=12), moderate intensity exercise (MEG, n=8), or vigorous intensity exercise (VEG, n=8) group. Subjects in both exercise groups completed a 12-week exercise program (MEG, 3.6 to 5.2 METs; VEG, ≥5.2 METs) that was monitored by accelerometers. We assessed body mass index (BMI), total fat area (TFA), visceral fat area (VFA), subcutaneous fat area (SFA), mid-thigh intramuscular adipose tissue (TIMAT), total skeletal muscle (TTM), low density skeletal muscle (TLDM), and normal density skeletal muscle (TNDM) using computed tomography, and measured insulin sensitivity with an insulin tolerance test (K_ITT), before and after the intervention.

Results

At baseline, the mean age was 53.8±7.9 years, duration of diabetes was 3.8±2.3 years, and BMI was 26.6±2.6 kg/m². After 12 weeks, the percent change (%C) in BMI, TIMAT, and TLDM were not different among three groups. However, %C in TFA and VFA were significantly reduced in MEG compared to CG (P=0.026 and P=0.008, respectively). %C SFA was significantly reduced in VEG compared to CG (P=0.038) and %C TTM, TNDM, and K_ITT were significantly increased in VEG compared to the CG (P=0.044, P=0.007, and P=0.016, respectively).

Conclusion

Although there was no difference in the change in BMI among groups, TFA and VFA were more reduced in MEG, and only VEG increased TTM, TNDM, and insulin sensitivity compared to CG.

Citations

Citations to this article as recorded by

Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review
Konstantinos Prokopidis, Alyssa N. Varanoske, Nicola Veronese, Ben Kirk, Konstantinos Katsikas Triantafyllidis, Christoforos D. Giannaki, Pinelopi S. Stavrinou, David D. Church, Gustavo Duque
Aging Clinical and Experimental Research.2025;[Epub] CrossRef
Comparative Efficacy of Exercise Type on Visceral Adipose Tissue in Patients With Prediabetes and Type 2 Diabetes Mellitus: A Systematic Review With Pairwise and Network Meta‐Analyses
Mousa Khalafi, Saeid Fatolahi, Michael E. Symonds, Farnaz Dinizadeh, Sara K. Rosenkranz, Alexios Batrakoulis
Obesity Reviews.2025;[Epub] CrossRef
The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Aerobic Exercise and Weight Loss in Adults
Ahmad Jayedi, Sepideh Soltani, Alireza Emadi, Mahdieh-Sadat Zargar, Ali Najafi
JAMA Network Open.2024; 7(12): e2452185. CrossRef
Intermuscular adipose tissue in metabolic disease
Bret H. Goodpaster, Bryan C. Bergman, Andrea M. Brennan, Lauren M. Sparks
Nature Reviews Endocrinology.2023; 19(5): 285. CrossRef
Dose–response effects of exercise and caloric restriction on visceral adiposity in overweight and obese adults: a systematic review and meta-analysis of randomised controlled trials
Francesco Recchia, Chit K. Leung, Angus P. Yu, Welton Leung, Danny J. Yu, Daniel Y. Fong, David Montero, Chi-Ho Lee, Stephen H.S. Wong, Parco M. Siu
British Journal of Sports Medicine.2023; 57(16): 1035. CrossRef
Muscle quality: the assessment, prognosis, and intervention
翔畑中, 洋祐大須賀
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics.2023; 60(2): 103. CrossRef
Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function
Kristine M. Erlandson, Triin Umbleja, Michael T. Lu, Jana Taron, Heather J. Ribaudo, Edgar T. Overton, Rachel M. Presti, David W. Haas, Paul E. Sax, Michael T. Yin, Bingxue Kris Zhai, Rochelle Louis, Namrata Upadhyay, Parastou Eslami, Pamela S. Douglas, M
JAIDS Journal of Acquired Immune Deficiency Syndromes.2023; 94(2): 174. CrossRef
Aerobic training reduces pancreatic fat content and improves β‐cell function: A randomized controlled trial using IDEAL‐IQ magnetic resonance imaging
Min Li, Qidong Zheng, Joshua D. Miller, Panpan Zuo, Xiaodan Yuan, Jitao Feng, Chao Liu, Shan Bao, Qingqing Lou
Diabetes/Metabolism Research and Reviews.2022;[Epub] CrossRef
Effect of aerobic exercise on waist circumference in adults with overweight or obesity: A systematic review and meta‐analysis
Alex Armstrong, Klaus Jungbluth Rodriguez, Angelo Sabag, Yorgi Mavros, Helen M. Parker, Shelley E. Keating, Nathan A. Johnson
Obesity Reviews.2022;[Epub] CrossRef
Effect of exercise on myosteatosis in adults: a systematic review and meta-analysis
Robinson Ramírez-Vélez, Yasmin Ezzatvar, Mikel Izquierdo, Antonio García-Hermoso
Journal of Applied Physiology.2021; 130(1): 245. CrossRef
Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
International Journal of Obesity.2021; 45(5): 982. CrossRef
Exercise Training to Decrease Ectopic Intermuscular Adipose Tissue in Individuals With Chronic Diseases: A Systematic Review and Meta-Analysis
Mauro Tuñón-Suárez, Alvaro Reyes-Ponce, Rodrigo Godoy-Órdenes, Nicolás Quezada, Marcelo Flores-Opazo
Physical Therapy.2021;[Epub] CrossRef
Low-attenuation muscle is a predictor of diabetes mellitus: A population-based cohort study
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Nutrition.2020; 74: 110752. CrossRef
Drop-out ratio between moderate to high-intensity physical exercise treatment by patients with, or at risk of, type 2 diabetes mellitus: A systematic review and meta-analysis
Guillem Jabardo-Camprubí, Rafel Donat-Roca, Mercè Sitjà-Rabert, Raimon Milà-Villarroel, Judit Bort-Roig
Physiology & Behavior.2020; 215: 112786. CrossRef
High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in Middle-Aged and Older Patients with Type 2 Diabetes: A Randomized Controlled Crossover Trial of the Acute Effects of Treadmill Walking on Glycemic Control
Romeu Mendes, Nelson Sousa, José Luís Themudo-Barata, Victor Machado Reis
International Journal of Environmental Research and Public Health.2019; 16(21): 4163. CrossRef
Trunk muscle quality assessed by computed tomography: Association with adiposity indices and glucose tolerance in men
Alexandre Maltais, Natalie Alméras, Isabelle Lemieux, Angelo Tremblay, Jean Bergeron, Paul Poirier, Jean-Pierre Després
Metabolism.2018; 85: 205. CrossRef
Counting Footsteps with a Pedometer to Improve HMW Adiponectin and Metabolic Syndrome among Young Female Adults in the United Arab Emirates
Hayder Hasan, Amita Attlee, Hamid Jan Bin Jan Mohamed, Norliyana Aris, Wan Abdul Manan Bin Wan Muda
Journal of Obesity.2018; 2018: 1. CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
Acta Diabetologica.2016; 53(5): 769. CrossRef
A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
Obesity Reviews.2016; 17(8): 664. CrossRef
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Thomas Brioche, Allan F. Pagano, Guillaume Py, Angèle Chopard
Molecular Aspects of Medicine.2016; 50: 56. CrossRef
Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes
Ji Yeon Jung, Kyung Wan Min, Hee Jung Ahn, Hwi Ryun Kwon, Jae Hyuk Lee, Kang Seo Park, Kyung Ah Han
Diabetes & Metabolism Journal.2014; 38(6): 439. CrossRef
Intermuscular Fat: A Review of the Consequences and Causes
Odessa Addison, Robin L. Marcus, Paul C. LaStayo, Alice S. Ryan
International Journal of Endocrinology.2014; 2014: 1. CrossRef
Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome
Byung Sam Park, Ji Sung Yoon
Diabetes & Metabolism Journal.2013; 37(6): 458. CrossRef
Effect of exercise on abdominal fat loss in men and women with and without type 2 diabetes
Devon A Dobrosielski, Bethany Barone Gibbs, Sameer Chaudhari, Pamela Ouyang, Harry A Silber, Kerry J Stewart
BMJ Open.2013; 3(11): e003897. CrossRef

Effects of Resistance Training and Aerobic Exercise on Insulin Sensitivity in Overweight Korean Adolescents: A Controlled Randomized Trial: Sunghwan Suh, In-Kyong Jeong, Mi Yeon Kim, Yeon Soo Kim, Sue Shin, Sun Sin Kim, Jae Hyeon Kim; Diabetes Metab J. 2011;35(4):418-426. Published online August 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.4.418

29,217 View
89 Download
27 Crossref

Abstract PDF PubReader ePub

Background

Data on the impact of resistance training on insulin resistance in overweight or obese children are inconclusive.

Methods

Thirty overweight South Korean adolescents (mean age of 13.10 years) were divided by sex, and then randomly assigned to one of three treatment groups, which were the diet only (DO), diet with aerobic exercise (AE), or diet with resistance training (RT) group. Physiologic and metabolic parameters were assessed at baseline and after 12 weeks of exercise training and diet modification.

Results

Both exercise groups (aerobic and resistance) showed significant improvements in their insulin area under the curve and insulin sensitivity index values when compared to their baseline values while the DO group showed no significant changes in these variables. Age-, sex-, and body mass index (BMI)-adjusted intergroup comparison analyses showed a marked reduction in BMI and a significant reduction in muscle mass in the AE group when compared to the RT group and the DO group, respectively.

Conclusion

A 12-week exercise training program of either resistance or aerobic activity improved insulin sensitivity in overweight adolescents, although it failed to show superiority over a DO program. Aerobic exercise decreased both body weight and BMI, and it was noted that this group also had a significant reduction in muscle mass when compared to the DO group.

Citations

Citations to this article as recorded by

Individual Variability in Insulin Sensitivity, Visceral Fat, and Cardiorespiratory Fitness in Response to Exercise in Adolescents with Obesity
Parmis Mirzadeh, SoJung Lee, Silva Arslanian, Jennifer L. Kuk
Nutrition, Metabolism and Cardiovascular Diseases.2026; : 104615. CrossRef
Impact of exercise on anthropometric outcomes in children and adolescents with overweight or obesity: a systematic review and meta-analysis based on 113 randomized controlled trials worldwide
Jie Men, Pengbo Wang, Qihui Gao, Yishan Li, Guoyu Zhu, Zhengyang Yu, Simin Wu, Yuxi Zhang, Weiqi An, Jingwen Wang, Yu Wu, Zhaowei Li, Jun Zhang
BMC Public Health.2025;[Epub] CrossRef
Role of Yoga in Distinctly Targeting Modifiable Risk Factors in Type 2 Diabetes to Improve Immuno-Metabolic Axis
Harshit B Joshi, Aswathy S Nair, Ramya Bellave, Krishna Raghava Hebbar, Anupama Nayak, Nandi Krishnamurthy Manjunath, Shashikiran Umakanth, Basavaraj Hadapad, Manjunath B Joshi
Journal of Evidence-Based Integrative Medicine.2025;[Epub] CrossRef
Is aerobic combined with resistance training a more suitable exercise program for obese college students? Evidence-based on subjective reports and objective measurements
Yan Li, Yanbin Hu
Frontiers in Physiology.2025;[Epub] CrossRef
Effect of high-intensity interval training and moderate-intensity continuous training on cardiovascular risk factors in adolescents: Systematic review and meta-analysis of randomized controlled trials
Ya Wang, Shun Wang, Xiangwu Meng, Husheng Zhou
Physiology & Behavior.2024; 275: 114459. CrossRef
Exploring molecular mechanisms of exercise on metabolic syndrome: a bibliometric and visualization study using CiteSpace
Kang Wan, Yue Jin, Ruobing Fan, Qizi Xu, Xiaoshi Li, Hongmei Yan, Ru Wang
Frontiers in Endocrinology.2024;[Epub] CrossRef
Exercise and Nutrition Strategies for Combating Sarcopenia and Type 2 Diabetes Mellitus in Older Adults
Dionysia Argyropoulou, Nikolaos D. Geladas, Tzortzis Nomikos, Vassilis Paschalis
Journal of Functional Morphology and Kinesiology.2022; 7(2): 48. CrossRef
Effects and dose-response relationships of exercise intervention on weight loss in overweight and obese children: a meta-regression and system review
Rui Xu, Qiao-Ting Huang, Yu-Ting Chen, Peng-Yin Wang
Journal of Pediatric Endocrinology and Metabolism.2022; 35(9): 1117. CrossRef
The Benefits of Resistance Training in Obese Adolescents: A Systematic Review and Meta-analysis
Bruno Ribeiro, Pedro Forte, Raquel Vinhas, Daniel A. Marinho, Luís B. Faíl, Ana Pereira, Fernando Vieira, Henrique P. Neiva
Sports Medicine - Open.2022;[Epub] CrossRef
Effects of Eight Weeks of Combined Training with Antioxidant Vitamins E and C on Glutathione, Glutathione Peroxidase, and Superoxide Dismutase in the Heart Tissue of Streptozotocin-induced Diabetic Rats
Elaheh Heydarnia, Farzaneh Taghian, Khosro Jalali Dehkodi, Mehrzad Moghadasi
Gene, Cell and Tissue.2021;[Epub] CrossRef
Effect of resistance training with and without caloric restriction on visceral fat: A systemic review and meta‐analysis
Mousa Khalafi, Abbas Malandish, Sara K. Rosenkranz, Ali A. Ravasi
Obesity Reviews.2021;[Epub] CrossRef
IMPACT OF TREADMILL RUNNING ON BLOOD GLUCOSE LEVEL OF TYPE 2 DIABETES MELLITUS PATIENTS IN GHURKI TRUST AND TEACHING HOSPITAL
Samiya Noreen, Muhammad Shafique, Tayyaba Mustafa Mian, Hafiz Abdul Rehman, Abdul Rehman, Muhammad Saad Shafiq, Ibraheem Zafar, Ramsha Masood
Pakistan BioMedical Journal.2021;[Epub] CrossRef
Role of exercise on insulin sensitivity and beta-cell function: is exercise sufficient for the prevention of youth-onset type 2 diabetes?
Joon Young Kim, Justin Y. Jeon
Annals of Pediatric Endocrinology & Metabolism.2020; 25(4): 208. CrossRef
Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis
LiQiang Su, JinMei Fu, ShunLi Sun, GuangGao Zhao, Wei Cheng, ChuanChuan Dou, MingHui Quan, Belinda Parmenter
PLOS ONE.2019; 14(1): e0210644. CrossRef
What Is the Role of Resistance Exercise in Improving the Cardiometabolic Health of Adolescents with Obesity?
SoJung Lee, YoonMyung Kim, Jennifer L. Kuk
Journal of Obesity & Metabolic Syndrome.2019; 28(2): 76. CrossRef
Does exercise training affect resting metabolic rate in adolescents with obesity?
Angela S. Alberga, Denis Prud’homme, Ronald J. Sigal, Gary S. Goldfield, Stasia Hadjiyannakis, Réjeanne Gougeon, Penny Phillips, Janine Malcolm, George A. Wells, Steve Doucette, Jinhui Ma, Glen P. Kenny
Applied Physiology, Nutrition, and Metabolism.2017; 42(1): 15. CrossRef
Iniciación al entrenamiento de fuerza en edades tempranas: revisión
G. Peña, J.R. Heredia, C. Lloret, M. Martín, M.E. Da Silva-Grigoletto
Revista Andaluza de Medicina del Deporte.2016; 9(1): 41. CrossRef
Effects of aerobic training, resistance training, or both on cardiorespiratory and musculoskeletal fitness in adolescents with obesity: the HEARTY trial
Angela S. Alberga, Denis Prud’homme, Ronald J. Sigal, Gary S. Goldfield, Stasia Hadjiyannakis, Penny Phillips, Janine Malcolm, Jinhui Ma, Steve Doucette, Rejeanne Gougeon, George A. Wells, Glen P. Kenny
Applied Physiology, Nutrition, and Metabolism.2016; 41(3): 255. CrossRef
The response of circulating omentin-1 concentration to 16-week exercise training in male children with obesity
Farzad Zehsaz, Negin Farhangi, Mehri Ghahramani
The Physician and Sportsmedicine.2016; 44(4): 355. CrossRef
Epidemiology of Childhood Obesity in Korea
Kyoung Hwa Ha, Dae Jung Kim
Endocrinology and Metabolism.2016; 31(4): 510. CrossRef
Muscle strength in youth and cardiovascular risk in young adulthood (the European Youth Heart Study)
Anders Grøntved, Mathias Ried-Larsen, Niels Christian Møller, Peter Lund Kristensen, Karsten Froberg, Søren Brage, Lars Bo Andersen
British Journal of Sports Medicine.2015; 49(2): 90. CrossRef
Position statement on youth resistance training: the 2014 International Consensus
Rhodri S Lloyd, Avery D Faigenbaum, Michael H Stone, Jon L Oliver, Ian Jeffreys, Jeremy A Moody, Clive Brewer, Kyle C Pierce, Teri M McCambridge, Rick Howard, Lee Herrington, Brian Hainline, Lyle J Micheli, Rod Jaques, William J Kraemer, Michael G McBride
British Journal of Sports Medicine.2014; 48(7): 498. CrossRef
Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study
Claudia-María Velásquez-Rodríguez, Marcela Velásquez-Villa, Leidy Gómez-Ocampo, Juliana Bermúdez-Cardona
BMC Pediatrics.2014;[Epub] CrossRef
Exercise and Insulin Resistance in Youth: A Meta-Analysis
Michael V. Fedewa, Nicholas H. Gist, Ellen M. Evans, Rod K. Dishman
Pediatrics.2014; 133(1): e163. CrossRef
What is the Effect of Resistance Training on the Strength, Body Composition and Psychosocial Status of Overweight and Obese Children and Adolescents? A Systematic Review and Meta-Analysis
Natasha Schranz, Grant Tomkinson, Tim Olds
Sports Medicine.2013; 43(9): 893. CrossRef
A Review of Randomized Controlled Trials of Aerobic Exercise Training on Fitness and Cardiometabolic Risk Factors in Obese Adolescents
A. S. Alberga, A. Frappier, R. J. Sigal, D. Prud'homme, G. P. Kenny
The Physician and Sportsmedicine.2013; 41(2): 44. CrossRef
Effects of Aerobic Versus Resistance Exercise Without Caloric Restriction on Abdominal Fat, Intrahepatic Lipid, and Insulin Sensitivity in Obese Adolescent Boys
SoJung Lee, Fida Bacha, Tamara Hannon, Jennifer L. Kuk, Chris Boesch, Silva Arslanian
Diabetes.2012; 61(11): 2787. CrossRef

Effects of Aerobic Exercise vs. Resistance Training on Endothelial Function in Women with Type 2 Diabetes Mellitus: Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Jae Hyuk Lee, Gang Seo Park, Kyung Ah Han; Diabetes Metab J. 2011;35(4):364-373. Published online August 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.4.364

14,515 View
134 Download
79 Crossref

Abstract PDF PubReader ePub

Background

There is controversy over whether aerobic or resistance exercise is more effective for improving endothelial function in type 2 diabetes mellitus (T2DM). This study was aimed to investigate the effects of an aerobic and resistance training program on endothelial function, and the influences of glycemic control, body weight changes, and aerobic capacity in T2DM.

Methods

Total 40 overweight women with T2DM were assigned into 3 groups: an aerobic exercise group (AEG, n=13), resistance exercise group (REG, n=12), and control group (CG, n=15), and followed either brisk walking for the AEG or resistance band training for the REG, 60 minutes per day, 5 days per week for 12 weeks with monitoring daily activity using accelerometers. We assessed endothelial function by flow-mediated dilation (FMD), and aerobic capacity by oxygen uptake at anaerobic threshold (AT_VO₂) at baseline and following training program.

Results

The mean participants' age was 57.0±6.8 years, and body mass index (BMI) was 27.0±2.3 kg/m². After intervention, FMD increased by 2.2±1.9% in AEG, which differed from REG and CG (P=0.002), despite of decreased body weight (BW) in both AG and RG (2.8±2.5%, P=0.002; 1.6±2.0%, P=0.017, respectively). A significant increased AT_VO₂ and decreased HbA1c were found only in AEG. In all participants, FMD was changed with the significant relations to the AT_VO₂ (r=0.348, P=0.035), but not to HbA1c levels or BW.

Conclusion

Aerobic exercise appears to be more beneficial than resistance exercise for improving endothelial function in T2DM. In addition, aerobic capacity could be a better predictor of changes in FMD than BW and glycemic control.

Citations

Citations to this article as recorded by

Circular RNA-Directed Therapeutic Strategy for Cold–Induced Diabetic Macrovascular Disease
Nan Jia, Kangling Xie, Cui Li, Yangjie Li, Yujiao Zong, Jiahao Li, Fan Hu, Ying Cai
Antioxidants & Redox Signaling.2026;[Epub] CrossRef
Effects of moderate-intensity aerobic exercise on coronary artery structure and function in type 2 diabetic rats
Dan Wang, Yaodong Guo, Lianhua Yin, Zhiwei Yan, Chenxi Li, Xiao Liu, Yiping Liu
Scientific Reports.2026;[Epub] CrossRef
Influence of different exercise types on vascular endothelial function in middle-aged and older adults – A systematic review and network meta-analysis
Qin Chen, Xin Gao, Chen Wang, Peizhen Zhang
Archives of Gerontology and Geriatrics.2025; 128: 105624. CrossRef
Optimal strategies for exercise intervention in older people diabetic patients: The impacts of intensity, form, and frequency on glycemic control
Xueru Yan, Yujuan Lu, Haoda Zhang, Chen Zhu, Lan Tian, Jishuai Chen, Enpeng He, Yingying Li
Archives of Gerontology and Geriatrics.2025; 128: 105621. CrossRef
Effects of home- and gym-based resistance training on glycemic control in patients with type 2 diabetes mellitus—a systematic review and meta-analysis
Magnus Bärg, Veronica Idiart-Borda Polotto, Stefanie Geiger, Steffen Held, Christian Brinkmann
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Arteries and Hearts in Motion: Sex Differences in Exercise-Mediated Protection Against Atherosclerotic Cardiovascular Disease Risk
Zachary S. Clayton, Mackenzie N. Kehmeier, Ryan Rosenberry, Emily A. Larson, Amélie Debray, Susan Cheng, Kerrie L. Moreau
Current Atherosclerosis Reports.2025;[Epub] CrossRef
Intervention effect of combined resistance and aerobic exercise on type 2 diabetes: A meta-analysis
Jiang-Chen Ma, Song Shu, Tian-Xiao Chen, Hui-Jing Bai, Ya Yang, Xiao-Wei Ding
World Journal of Diabetes.2025;[Epub] CrossRef
Comparative effectiveness of various combined interventions for type 2 diabetes and obesity: a systematic review and network meta-analysis
Li Cui, Donglei Lu, Sijie Tan, Liquan Cao
Frontiers in Endocrinology.2025;[Epub] CrossRef
Effects of different exercise types on vascular endothelial function in individuals with abnormal glycaemic control: a systematic review and network meta-analysis
Zongxiang Li, Shengyao Luo, Xuebing Bai, Lu Huang, Hongyan Guo, Song Chen, Dan Wang
PeerJ.2025; 13: e19839. CrossRef
The effects of resistance training on glycemic control, cardiometabolic health, and body composition in middle-aged and older women with type 2 diabetes and overweight or obesity: A systematic review and meta-analysis
Ruojiang Liu, Xiaofeng Shi, Xiang Zhang
Maturitas.2025; 201: 108691. CrossRef
Resistance training enhances metabolic and muscular health and reduces systemic inflammation in middle-aged and older adults with type 2 diabetes: a meta-analysis
Jingwen Wang, Shiqian Fan, Jianshe Wang
Diabetes Research and Clinical Practice.2025; 229: 112941. CrossRef
Comparing Aerobic Interval Training with Other Forms of Physical Exercise for Brachial Artery Endothelial Function Improvement: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials
Armin H. Paravlic, Simon Iskra, Ensar Abazovic, Nicola Lamberti, Fabio Manfredini, Kristina Drole
Sports Medicine - Open.2025;[Epub] CrossRef
The effect of exercise on flow-mediated dilation in people with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Bopeng Qiu, Yilun Zhou, Xifeng Tao, Xiao Hou, Liwen Du, Yuanyuan Lv, Laikang Yu
Frontiers in Endocrinology.2024;[Epub] CrossRef
The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Yuwen Wan, Zhanguo Su
Biological Research For Nursing.2024; 26(4): 597. CrossRef
The effects of resistance training on cardiovascular factors and anti-inflammation in diabetic rats
Jin Yoo, Jinsu Hwang, Jiyun Choi, Mahesh Ramalingam, Haewon Jeong, Sujeong Jang, Han-Seong Jeong, Daeyeol Kim
Heliyon.2024; 10(17): e37081. CrossRef
Protocol for a randomized controlled trial of moderate intensity interval training in individuals with chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome who have excessive daytime sleepiness
Madalina Macrea, Richard Casaburi, Richard ZuWallack, Atul Malhotra, Kris Ann Oursler
Contemporary Clinical Trials.2024; 145: 107663. CrossRef
A systematic review and meta‐analysis on effect of different exercise training on grip strength and upper extremity muscle strength in patients with type 2 diabetes mellitus
Mamta Boora, Manoj Malik, Jaspreet Kaur
Physiotherapy Research International.2024;[Epub] CrossRef
The Impact of Various Types of Exercise on Lipid Metabolism in Patients with Type 2 Diabetes and Concurrent Overweight/Obesity: A Narrative Review
Sameer Badri Al-mhanna, Wan Syaheedah Wan Ghazali, Alexios Batrakoulis, Nouf H. Alkhamees, Clemens Drenowatz, Mahaneem Mohamed, Mehmet Gülü, Hafeez Abiola Afolabi, Georgian Badicu
Annals of Applied Sport Science.2024;[Epub] CrossRef
Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Yan Sun, Mingwei Sun, Xia Zeng, Liojuan Xiang Je, Zhannguo Su Guo
Acta Diabetologica.2024; 62(1): 11. CrossRef
Low-Intensity Resistance Training Improves Flow-Mediated Dilation in Young Hispanic Adults
José M. Briceño-Torres, Elizabeth Carpio-Rivera, Andrea Solera-Herrera, Jeffrey Forsse, Peter W. Grandjean, José Moncada-Jiménez
Journal of Strength & Conditioning Research.2023; 37(2): 298. CrossRef
Intensity Differences of Resistance Training for Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis
Tenglong Fan, Man-Hsu Lin, Kijin Kim
Healthcare.2023; 11(3): 440. CrossRef
Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials
Xifeng Tao, Yiyan Chen, Kai Zhen, Shiqi Ren, Yuanyuan Lv, Laikang Yu
Frontiers in Physiology.2023;[Epub] CrossRef
Original article – Effect of different resistance training intensities on endothelial function in people with type 2 diabetes mellitus: A systematic review
Thiago Borges Madureira Sabino, Denise Maria Martins Vancea, Manoel da Cunha Costa, Raphael José Perrier de Melo, Iago Vilela Dantas, Jonathan Nicolas dos Santos Ribeiro
Diabetes Research and Clinical Practice.2023; 200: 110676. CrossRef
장기간의 저항성 트레이닝이 전문 보디빌더의 중심 동맥 혈압 및 경직도에 미치는 영향
동현 이, 원일 박, 재성 이, 형진 백, 광석 홍
The Korean Journal of Physical Education.2023; 62(4): 1. CrossRef
Dose-response relationships of resistance training in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials
Wanying Su, Meiyi Tao, Lin Ma, Ke Tang, Fang Xiong, Xuan Dai, Yuelan Qin
Frontiers in Endocrinology.2023;[Epub] CrossRef
Insight into type 2 diabetes impaired exercising mitochondrial oxidative flux: is it blood flow, mitochondria, or neither?
Noah A. John, Liam T. O'Brien
The Journal of Physiology.2022; 600(4): 707. CrossRef
Does exercise training improve the function of vascular smooth muscle? A systematic review and meta-analysis
Yujia Liu, Zhenjia Sun, Tong Chen, Chen Yang
Research in Sports Medicine.2022; 30(6): 577. CrossRef
Effect of resistance training on HbA1c in adults with type 2 diabetes mellitus and the moderating effect of changes in muscular strength: a systematic review and meta-analysis
Anna K Jansson, Li X Chan, David R Lubans, Mitch J Duncan, Ronald C Plotnikoff
BMJ Open Diabetes Research & Care.2022; 10(2): e002595. CrossRef
Does Aerobic plus Machine-Assisted Resistance Training Improve Vascular Function in Type 2 Diabetes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Trial Sequential Analysis
Xianshan Guo, Shizhe Guo, Hongmei Zhang, Zhen Li
Journal of Clinical Medicine.2022; 11(15): 4257. CrossRef
Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training
Małgorzata Jamka, Paweł Bogdański, Patrycja Krzyżanowska-Jankowska, Anna Miśkiewicz-Chotnicka, Joanna Karolkiewicz, Monika Duś-Żuchowska, Radosław Mądry, Aleksandra Lisowska, Anna Gotz-Więckowska, Saule Iskakova, Jarosław Walkowiak, Edyta Mądry
Journal of Clinical Medicine.2021; 10(8): 1639. CrossRef
The Role of Physical Therapy in the Combined Treatment of Patients with Lower Extremities Diabetic Angiopathies
Denis V. Frolov
Bulletin of Rehabilitation Medicine.2021; 20(2): 80. CrossRef
Low-to-Moderate-Intensity Resistance Exercise Is More Effective than High-Intensity at Improving Endothelial Function in Adults: A Systematic Review and Meta-Analysis
Yong Zhang, Ya-Jun Zhang, Hong-Wei Zhang, Wei-Bing Ye, Mallikarjuna Korivi
International Journal of Environmental Research and Public Health.2021; 18(13): 6723. CrossRef
Effects of resistance training on endothelial function: A systematic review and meta-analysis
Jessika Karla T.N.F. Silva, Annelise L. Menêses, Belinda J. Parmenter, Raphael M. Ritti-Dias, Breno Q. Farah
Atherosclerosis.2021; 333: 91. CrossRef
Vascular Ageing and Aerobic Exercise
Michaela Kozakova, Carlo Palombo
International Journal of Environmental Research and Public Health.2021; 18(20): 10666. CrossRef
High-Intensity Endurance and Strength Training in Water Polo Olympic Team Players: Impact on Arterial Wall Properties
Evangelos Oikonomou, Gerasimos Siasos, Georgios Marinos, Marina Zaromitidou, Dimitris Athanasiou, Petros Fountoulakis, Sotiris Tsalamandris, Georgios Charalambous, Georgios Lazaros, Charalambos Vlachopoulos, Dimitris Tousoulis
Cardiology.2021; 146(1): 119. CrossRef
Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta‐analysis
Pedro Acosta‐Manzano, María Rodriguez‐Ayllon, Francisco M. Acosta, David Niederseer, Josef Niebauer
Obesity Reviews.2020;[Epub] CrossRef
Aerobic Exercise Increases Tear Secretion and Decreases Inflammatory Cytokines in Healthy Subjects
Hao Li, Fei Li, Rouxi Zhou, Kai Gao, Lingyi Liang, Xiulan Zhang
Asia-Pacific Journal of Ophthalmology.2020; 9(5): 404. CrossRef
The Role of Aerobic Training Variables Progression on Glycemic Control of Patients with Type 2 Diabetes: a Systematic Review with Meta-analysis
Rodrigo Sudatti Delevatti, Cláudia Gomes Bracht, Salime Donida Chedid Lisboa, Rochelle Rocha Costa, Elisa Corrêa Marson, Nathalie Netto, Luiz Fernando Martins Kruel
Sports Medicine - Open.2019;[Epub] CrossRef
Effect of Exercise on Risk Factors of Diabetic Foot Ulcers
Fuyuan Liao, Ruopeng An, Fang Pu, Stephanie Burns, Sa Shen, Yih-Kuen Jan
American Journal of Physical Medicine & Rehabilitation.2019; 98(2): 103. CrossRef
Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes
João S. Teodoro, Sara Nunes, Anabela P. Rolo, Flávio Reis, Carlos M. Palmeira
Frontiers in Physiology.2019;[Epub] CrossRef
Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial
Anderson Rech, Cíntia Ehlers Botton, Pedro Lopez, André Quincozes-Santos, Daniel Umpierre, Ronei Silveira Pinto
Experimental Gerontology.2019; 118: 19. CrossRef
Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
Yubo Liu, Weibing Ye, Qian Chen, Yong Zhang, Chia-Hua Kuo, Mallikarjuna Korivi
International Journal of Environmental Research and Public Health.2019; 16(1): 140. CrossRef
Effects of Resistance Exercise on Glycated Hemoglobin and Functional Performance in Older Patients with Comorbid Diabetes Mellitus and Knee Osteoarthritis: A Randomized Trial
Shu-Mei Chen, Feng-Chih Shen, Jung-Fu Chen, Wen-Dien Chang, Nai-Jen Chang
International Journal of Environmental Research and Public Health.2019; 17(1): 224. CrossRef
Endothelial function following interval exercise plus low‐calorie diet treatment in obese females
Nicole M. Gilbertson, Stephanie L. Miller, Natalie Z.M. Eichner, Steven K. Malin
Physiological Reports.2019;[Epub] CrossRef
The effects of exercise on vascular endothelial function in type 2 diabetes: a systematic review and meta-analysis
Jung-Hoon Lee, Ruda Lee, Moon-Hyon Hwang, Marc T. Hamilton, Yoonjung Park
Diabetology & Metabolic Syndrome.2018;[Epub] CrossRef
Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis
Shanhu Qiu, Xue Cai, Han Yin, Zilin Sun, Martina Zügel, Jürgen Michael Steinacker, Uwe Schumann
Cardiovascular Diabetology.2018;[Epub] CrossRef
Responses of healthy young males to fine-particle exposure are modified by exercise habits: a panel study
Xi Chen, Wu Chen, Yanwen Wang, Yiqun Han, Tong Zhu
Environmental Health.2018;[Epub] CrossRef
Aerobic exercise regulates blood lipid and insulin resistance via the toll‑like receptor 4‑mediated extracellular signal‑regulated kinases/AMP‑activated protein kinases signaling pathway
Mei Wang, Sen Li, Fubaihui Wang, Jinhui Zou, Yanfeng Zhang
Molecular Medicine Reports.2018;[Epub] CrossRef
Efectos del ejercicio físico en los factores de riesgo cardiovascular que constituyen el síndrome metabólico: una alternativa para reducir su tendencia
Adrián Hernández Alonso
Revista Colombiana de Médicina Física y Rehabilitación.2017; 27(2): 140. CrossRef
Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial
Anne Sofie Gram, Else-Marie Bladbjerg, Jonas Salling Quist, Martin Bæk Petersen, Mads Rosenkilde, Bente Stallknecht
Atherosclerosis.2017; 265: 318. CrossRef
The Effects of Exercise Training on Brachial Artery Flow-Mediated Dilation
Kate S. Early, Abigail Stewart, Neil Johannsen, Carl J. Lavie, Jerry R. Thomas, Michael Welsch
Journal of Cardiopulmonary Rehabilitation and Prevention.2017; 37(2): 77. CrossRef
Effects of Self-directed Exercise Programmes on Individuals with Type 2 Diabetes Mellitus: A Systematic Review Evaluating Their Effect on HbA1c and Other Metabolic Outcomes, Physical Characteristics, Cardiorespiratory Fitness and Functional Outcomes
Hugh Byrne, Brian Caulfield, Giuseppe De Vito
Sports Medicine.2017; 47(4): 717. CrossRef
Effects of Combination of Baduanjin and Elastic Band on Physical Fitness and Glycemic Control in Patients with Type 2 Diabetes Mellitus
强庄
Advances in Physical Sciences.2017; 05(01): 5. CrossRef
Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes
Eliza G. Miller, Parneet Sethi, Caryl A. Nowson, David W. Dunstan, Robin M. Daly
European Journal of Applied Physiology.2017; 117(8): 1669. CrossRef
Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men
Else-Marie Bladbjerg, Jane Skov, Pernille Nordby, Bente Stallknecht
Thrombosis Research.2017; 152: 69. CrossRef
Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis
Younsun Son, Kyungun Kim, Soeun Jeon, Minsoo Kang, Sukho Lee, Yoonjung Park
International Journal of Vascular Medicine.2017; 2017: 1. CrossRef
Effects of Elastic Band Resistance Training on Glucose Control, Body Composition, and Physical Function in Women With Short- vs. Long-Duration Type-2 Diabetes
Bong-Sup Park, Andy V. Khamoui, Lee E. Brown, Do-Youn Kim, Kyung-Ah Han, Kyung-Wan Min, Geun-Hee An
Journal of Strength and Conditioning Research.2016; 30(6): 1688. CrossRef
Glycemic reductions following water- and land-based exercise in patients with type 2 diabetes mellitus
Rodrigo Sudatti Delevatti, Carolina Dertzbocher Feil Pinho, Ana Carolina Kanitz, Cristine Lima Alberton, Elisa Corrêa Marson, Luciana Peruchena Bregagnol, Salime Chedid Lisboa, Beatriz D. Schaan, Luiz Fernando Martins Kruel
Complementary Therapies in Clinical Practice.2016; 24: 73. CrossRef
Short-term exercise training improves flow-mediated dilation and circulating angiogenic cell number in older sedentary adults
Rian Q. Landers-Ramos, Kelsey J. Corrigan, Lisa M. Guth, Christine N. Altom, Espen E. Spangenburg, Steven J. Prior, James M. Hagberg
Applied Physiology, Nutrition, and Metabolism.2016; 41(8): 832. CrossRef
Glucose control can be similarly improved after aquatic or dry-land aerobic training in patients with type 2 diabetes: A randomized clinical trial
Rodrigo S. Delevatti, Ana Carolina Kanitz, Cristine L. Alberton, Elisa Corrêa Marson, Salime Chedid Lisboa, Carolina Dertzbocher Feil Pinho, Gisele A. Lovatel, Arthiese Korb, Karine Bertoldi, Rodrigo C.O. Macedo, Ionara R. Siqueira, Beatriz D. Schaan, Lui
Journal of Science and Medicine in Sport.2016; 19(8): 688. CrossRef
Assessment of endothelial function by flow-mediated dilation in diabetic patients: Effects of physical exercise
Aline P Jarrete, Angelina Zanesco, Maria Andréia Delbin
Motriz: Revista de Educação Física.2016; 22(1): 3. CrossRef
Psychosocial Variables Related to Why Women are Less Active than Men and Related Health Implications
Elizabeth Skidmore Edwards, Sarah Carson Sackett
Clinical Medicine Insights: Women's Health.2016; 9s1: CMWH.S34668. CrossRef
In Search of the Ideal Resistance Training Program to Improve Glycemic Control and its Indication for Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Hajime Ishiguro, Satoru Kodama, Chika Horikawa, Kazuya Fujihara, Ayumi Sugawara Hirose, Reiko Hirasawa, Yoko Yachi, Nobumasa Ohara, Hitoshi Shimano, Osamu Hanyu, Hirohito Sone
Sports Medicine.2016; 46(1): 67. CrossRef
Effects of exercise training using resistance bands on glycaemic control and strength in type 2 diabetes mellitus: a meta-analysis of randomised controlled trials
Samantha K. McGinley, Marni J. Armstrong, Normand G. Boulé, Ronald J. Sigal
Acta Diabetologica.2015; 52(2): 221. CrossRef
Impact of combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats
Iris C. Sanches, Filipe F. Conti, Nathalia Bernardes, Janaina de O Brito, Elia G. Galdini, Cláudia R. Cavaglieri, Maria-Cláudia Irigoyen, Kátia De Angelis
Journal of Applied Physiology.2015; 119(6): 656. CrossRef
Three months of strictly controlled daily endurance exercise reduces thrombin generation and fibrinolytic risk markers in younger moderately overweight men
Anne Sofie Gram, Else-Marie Bladbjerg, Jane Skov, Thorkil Ploug, Anders Sjödin, Mads Rosenkilde, Daniel Elenius Madsen, Bente Merete Stallknecht
European Journal of Applied Physiology.2015; 115(6): 1331. CrossRef
Exercise Modalities and Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials
Ammar W. Ashor, Jose Lara, Mario Siervo, Carlos Celis-Morales, Clio Oggioni, Djordje G. Jakovljevic, John C. Mathers
Sports Medicine.2015; 45(2): 279. CrossRef
The Impact of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Vascular Function: a Systematic Review and Meta-Analysis
Joyce S. Ramos, Lance C. Dalleck, Arnt Erik Tjonna, Kassia S. Beetham, Jeff S. Coombes
Sports Medicine.2015; 45(5): 679. CrossRef
Safety of Aerobic Exercise in People With Diabetic Peripheral Neuropathy: Single-Group Clinical Trial
Patricia M. Kluding, Mamatha Pasnoor, Rupali Singh, Linda J. D'Silva, Min Yoo, Sandra A. Billinger, Joseph W. LeMaster, Mazen M. Dimachkie, Laura Herbelin, Douglas E. Wright
Physical Therapy.2015; 95(2): 223. CrossRef
Sleep and exercise: A reciprocal issue?
Mounir Chennaoui, Pierrick J. Arnal, Fabien Sauvet, Damien Léger
Sleep Medicine Reviews.2015; 20: 59. CrossRef
Blood glucose response to aerobic exercise training program among patients with type 2 diabetes mellitus at the University of Nigeria Teaching Hospital, Enugu South-East, Nigeria
C. I. Ezema, S. Lamina, Amarachi A. Onwunali, U. A. Ezugwu, A. A. Amaeze, M. J. Nwankwo
International Journal of Diabetes in Developing Countries.2015; 35(S2): 88. CrossRef
Endothelial Function Increases after a 16-Week Diet and Exercise Intervention in Overweight and Obese Young Women
Lisa M. Cotie, Andrea R. Josse, Stuart M. Phillips, Maureen J. MacDonald
BioMed Research International.2014; 2014: 1. CrossRef
Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and network meta-analysis
Lukas Schwingshackl, Benjamin Missbach, Sofia Dias, Jürgen König, Georg Hoffmann
Diabetologia.2014; 57(9): 1789. CrossRef
Exercise as a Therapeutic Strategy for Primary Mitochondrial Cytopathies
Mark A. Tarnopolsky
Journal of Child Neurology.2014; 29(9): 1225. CrossRef
Effects of weight management by exercise modes on markers of subclinical atherosclerosis and cardiometabolic profile among women with abdominal obesity: a randomized controlled trial
Jina Choo, Juneyoung Lee, Jeong-Hyun Cho, Lora E Burke, Akira Sekikawa, Sae Young Jae
BMC Cardiovascular Disorders.2014;[Epub] CrossRef
Walking disability in patients with peripheral artery disease is associated with arterial endothelial function
S. Marlene Grenon, Karen Chong, Hugh Alley, Emily Nosova, Warren Gasper, Jade Hiramoto, W. John Boscardin, Christopher D. Owens
Journal of Vascular Surgery.2014; 59(4): 1025. CrossRef
Cardiovascular Function and Predictors of Exercise Capacity in Patients With Colorectal Cancer
Larissa Cramer, Bert Hildebrandt, Thomas Kung, Kristin Wichmann, Jochen Springer, Wolfram Doehner, Anja Sandek, Miroslava Valentova, Tatjana Stojakovic, Hubert Scharnagl, Hanno Riess, Stefan D. Anker, Stephan von Haehling
Journal of the American College of Cardiology.2014; 64(13): 1310. CrossRef
Effects of Exercise Training on Arterial Function in Type 2 Diabetes Mellitus
David Montero, Guillaume Walther, Eric Benamo, Antonia Perez-Martin, Agnès Vinet
Sports Medicine.2013; 43(11): 1191. CrossRef
A randomized trial of exercise for blood pressure reduction in type 2 diabetes: Effect on flow-mediated dilation and circulating biomarkers of endothelial function
Bethany Barone Gibbs, Devon A. Dobrosielski, Susanne Bonekamp, Kerry J. Stewart, Jeanne M. Clark
Atherosclerosis.2012; 224(2): 446. CrossRef

Exercise Treadmill Test in Detecting Asymptomatic Coronary Artery Disease in Type 2 Diabetes Mellitus: Mee Kyoung Kim, Ki Hyun Baek, Ki Ho Song, Hyuk Sang Kwon, Jung Min Lee, Moo Il Kang, Kun Ho Yoon, Bong Yun Cha, Ho Young Son, Kwang Woo Lee; Diabetes Metab J. 2011;35(1):34-40. Published online February 28, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.1.34

28,500 View
62 Download
16 Crossref

Abstract PDF PubReader ePub

Background

The present study was designed to develop criteria for screening patients with type 2 diabetes mellitus (T2DM) for asymptomatic coronary artery disease (CAD).

Methods

A total of 213 patients with T2DM without typical angina or chest pain were studied between 2002 and 2007. We also evaluated 53 patients with T2DM who had reported chest discomfort using an exercise treadmill test (ETT).

Results

Thirty-one of the 213 asymptomatic patients had positive ETT results. We performed coronary angiography on 23 of the 31 patients with a positive ETT and found that 11 of them had significant coronary stenosis. The main differences between the patients with significant stenosis and those with a negative ETT were age (63.1±9.4 vs. 53.7±10.1 years, P=0.008) and duration of diabetes (16.0±7.5 vs. 5.5±5.7 years, P<0.001). The positive predictive value (PPV) of the ETT was calculated to be 47.8%. The PPV of the ETT increased to 87.5% in elderly patients (≥60 years) with a long duration of diabetes (≥10 years). The latter value is similar to that of patients with T2DM who presented with chest discomfort or exertional dyspnea. The PPV of the ETT in symptomatic patients was 76.9%.

Conclusion

In the interest of cost-effectiveness, screening for asymptomatic CAD could be limited to elderly patients with a duration of diabetes ≥10 years.

Citations

Citations to this article as recorded by

Duke Treadmill Score Predicts Coronary Artery Disease Severity in Diabetics and Non-Diabetics
Muhammad Khalil, Muhammad Shafique Arshad, Asma Zafar Khawaja, Iffat Aqeel, . Hidayatullah, Mahboob Ur Rehman, Sumeet Kumar, Shoaib Ahmed
Pakistan Journal of Health Sciences.2023; : 126. CrossRef
Prevalence of Coronary Artery Disease in Asymptomatic type 2 Diabetes Mellitus Patients with Invasive Correlation in North India
V Kumar, B Yadav, A Nachankar
Indian Journal of Endocrinology and Metabolism.2023; 27(2): 133. CrossRef
Anatomical and Neuromuscular Factors Associated to Non-Contact Anterior Cruciate Ligament Injury
Marc Dauty, Vincent Crenn, Bastien Louguet, Jérôme Grondin, Pierre Menu, Alban Fouasson-Chailloux
Journal of Clinical Medicine.2022; 11(5): 1402. CrossRef
Prevalence of Asymptomatic Silent Myocardial Ischemia among Type 2 Diabetes Mellitus Patients in Bangalore - A Hospital-Based Cross-Sectional Study
Nagappa H Handargal, Shristi J Shetty
Journal of the Practice of Cardiovascular Sciences.2021; 7(3): 207. CrossRef
Influence of sex on the incidence of potential coronary artery disease and long-term outcomes in asymptomatic patients with diabetes mellitus
Chisato Sato, Kohei Wakabayashi, Naoko Ikeda, Yuki Honda, Ken Sato, Toshiaki Suzuki, Keita Shibata, Kaoru Tanno
IJC Heart & Vasculature.2020; 27: 100504. CrossRef
Gauging the Positive Predictive Value of Exercise Tolerance Test Using Angiographic Evaluation: A Cross-Sectional Analysis From a Developing Country
Ismail Khan, Maria Hasan, Javeria Hasan, Ali Imran Dhillon, Moosa Khan, Mehwish Kaneez
Cureus.2020;[Epub] CrossRef
EVALUATION OF SILENT MYOCARDIAL ISCHEMIA IN ASYMPTOMATIC TYPE 2 DIABETES MELLITUS PATIENTS BY TREAD MILL TEST IN TERTIARY CARE CENTER IN SOUTH INDIA
Malepati Sai Sarath Reddy, Uma Mylandlahalli Anandkumar, Srinivasa Rao
Journal of Evolution of Medical and Dental Sciences.2019; 8(10): 740. CrossRef
Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes
Stefan Kopf, Jan B. Groener, Zoltan Kender, Thomas Fleming, Maik Brune, Christin Riedinger, Nadine Volk, Esther Herpel, Dominik Pesta, Julia Szendrödi, Mark O. Wielpütz, Hans-Ulrich Kauczor, Hugo A. Katus, Michael Kreuter, Peter P. Nawroth
Respiration.2018; 96(1): 29. CrossRef
Comparison of the presence of fragmented QRS complexes in the inferior versus the anterior leads for predicting coronary artery disease severity
Mehmet Eyuboglu, Ugur Kucuk, Omer Senarslan, Bahri Akdeniz
Revista Portuguesa de Cardiologia.2017; 36(2): 89. CrossRef
Comparison of the presence of fragmented QRS complexes in the inferior versus the anterior leads for predicting coronary artery disease severity
Mehmet Eyuboglu, Ugur Kucuk, Omer Senarslan, Bahri Akdeniz
Revista Portuguesa de Cardiologia (English Edition).2017; 36(2): 89. CrossRef
High Serum Ykl-40 Level Positively Correlates With Coronary Artery Disease
Yan Jin, Jia-Ning Cao, Chun-Xia Wang, Qiu-Ting Feng, Xin-He Ye, Xin Xu, Cheng-Jian Yang
Biomarkers in Medicine.2017; 11(2): 133. CrossRef
Fragmented QRS Is Associated with Improved Predictive Value of Exercise Treadmill Testing in Patients with Intermediate Pretest Likelihood of Significant Coronary Artery Disease
Eyyup Tusun, Abdulselam Ilter, Feyzullah Besli, Emre Erkus, Ibrahim Halil Altiparmak, Mehmet Bozbay
Annals of Noninvasive Electrocardiology.2016; 21(2): 196. CrossRef
Use of imaging and clinical data to screen for cardiovascular disease in asymptomatic diabetics
Carlos Henrique Reis Esselin Rassi, Timothy W. Churchill, Carlos A. Fernandes Tavares, Mateus Guimaraes Fahel, Fabricia P. O. Rassi, Augusto H. Uchida, Bernardo L. Wajchenberg, Antonio C. Lerario, Edward Hulten, Khurram Nasir, Márcio S. Bittencourt, Carlo
Cardiovascular Diabetology.2016;[Epub] CrossRef
Obese sedentary patients with dyspnoea on exertion who are at low risk for coronary artery disease by clinical criteria have a very low prevalence of coronary artery disease
J. T. Bruckel, G. Larsen, M. R. Benson
Clinical Obesity.2014; 4(3): 143. CrossRef
Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee
Cardiovascular Diabetology.2012;[Epub] CrossRef
Exercise Treadmill Test for Evaluation of Cardiovascular Disease in Diabetic Patients
Ju Youn Kim, Mee Kyoung Kim, Woo-Baek Chung
The Journal of Korean Diabetes.2012; 13(4): 182. CrossRef

Effects of Aerobic Exercise on Abdominal Fat, Thigh Muscle Mass and Muscle Strength in Type 2 Diabetic Subject: Hwi Ryun Kwon, Kyung Wan Min, Hee Jung Ahn, Hee Geum Seok, Bo Kyung Koo, Ho Chul Kim, Kyung Ah Han; Korean Diabetes J. 2010;34(1):23-31. Published online February 28, 2010; DOI: https://doi.org/10.4093/kdj.2010.34.1.23

8,470 View
59 Download
20 Crossref

Abstract PDF PubReader ePub

Background

Aerobic exercise can effectively reduce visceral fat. However, few studies have examined the effect of daily physical activity on obesity and cardiopulmonary function in the subjects with diabetes. We examined the effect of moderate intensity of walking in obese diabetes patients by monitoring of daily activity and measuring the change in abdominal fat area, muscle are and maximal muscle strength.

Methods

We randomly assigned 27 obese women with type 2 diabetes to an aerobic exercise group (AG, n = 13) and control group (CG, n = 14). The AG performed moderate intensity walking for 60 minutes per exercise, 5 times per week, and for 12 weeks. The activity energy expenditure was monitored by a multi-record accelerometer. The CG maintained routine daily activities. At the time of the initiation of the study and after 12 weeks of exercise, the aerobic exercise capacity was assessed using oxygen consumption rate at anaerobic threshold (VO₂-AT). The abdominal fat area and the quadriceps muscle area were measured by computed tomography, and the maximum muscle strength of the upper and lower limbs was measured by a chest press and a leg press, respectively.

Results

The mean age of the study subjects was 56.6 ± 8.0 years, the mean duration of diabetes was 6.3 ± 6.0 years, and the body weight index (BMI) was 27.3 ± 2.7 kg/m². The BMI of the AG was significantly decreased (P = 0.003). In the AG, the visceral fat area and subcutaneous fat area were also significantly decreased (P = 0.018 and P < 0.001, respectively) but not in CG. VO₂-AT of the AG was significantly improved, while that of the CG did not change (P = 0.009 and P = 0.115, respectively). The quadriceps muscle mass and the maximal muscle strength of the AG did not change, however, the CG showed a significant decrease. Duration of moderate intensity exercise was correlated with the decrease in total abdominal fat area (r = -0.484; P = 0.011) and that of high intensity exercise was correlated with improvement of cardiopulmonary function (r = 0.414; P = 0.032).

Conclusion

Daily moderate intensity aerobic exercise is effective at reducing abdominal fat mass, while high intensity exercise improves cardiopulmonary function.

Citations

Citations to this article as recorded by

Are strategies to increase muscle mass and strength as effective in people with type 2 diabetes?
Amina A. Al-Awadi, Stuart R. Gray, Ebaa Al-Ozairi
Reviews in Endocrine and Metabolic Disorders.2025; 26(5): 857. CrossRef
Relationship Between Visceral Fat Tissue and Exercise
Ebru Ceviz
Türk Spor Bilimleri Dergisi.2024; 7(1): 10. CrossRef
The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Nasim Behzadnejad, Saba Belyani, Sara K. Rosenkranz, Reza Bagheri, Fred Dutheil
Journal of Clinical Medicine.2024; 13(17): 5005. CrossRef
Walking for subjects with type 2 diabetes: a systematic review and joint AMD/SID/SISMES evidence-based practical guideline
P. Moghetti, S. Balducci, L. Guidetti, P. Mazzuca, E. Rossi, F. Schena, P. Moghetti, S. Balducci, L. Guidetti, F. Schena, P. Mazzuca, E. Rossi
Sport Sciences for Health.2021; 17(1): 1. CrossRef
Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
Yu-Hsuan Chang, Hui-Ying Yang, Shiow-Ching Shun
International Journal of Obesity.2021; 45(5): 982. CrossRef
Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985. CrossRef
The Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
Siyao Gao, Jialing Tang, Guozhong Yi, Zhong Li, Zhenyin Chen, Ling Yu, Feng Zheng, Yajing Hu, Zhangui Tang
Diabetes Therapy.2021; 12(10): 2767. CrossRef
Walking for subjects with type 2 diabetes: A systematic review and joint AMD/SID/SISMES evidence-based practical guideline
P. Moghetti, S. Balducci, L. Guidetti, P. Mazzuca, E. Rossi, F. Schena
Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(11): 1882. CrossRef
Effect of Coordinative Locomotor Training Program on Body Fat and Muscle mass of Male University students
Hyung chun Nam, Nam jeong Cho, Jae yong Choi
Archives of Orthopedic and Sports Physical Therapy.2019; 15(2): 109. CrossRef
Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
Bei Pan, Long Ge, Yang-qin Xun, Ya-jing Chen, Cai-yun Gao, Xue Han, Li-qian Zuo, Hou-qian Shan, Ke-hu Yang, Guo-wu Ding, Jin-hui Tian
International Journal of Behavioral Nutrition and Physical Activity.2018;[Epub] CrossRef
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
A. Sabag, K.L. Way, S.E. Keating, R.N. Sultana, H.T. O’Connor, M.K. Baker, V.H. Chuter, J. George, N.A. Johnson
Diabetes & Metabolism.2017; 43(3): 195. CrossRef
A systematic review and meta‐analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue
R. J. H. M. Verheggen, M. F. H. Maessen, D. J. Green, A. R. M. M. Hermus, M. T. E. Hopman, D. H. T. Thijssen
Obesity Reviews.2016; 17(8): 664. CrossRef
Effects of Aerobic Exercise Associated with Abdominal Microcurrent: A Preliminary Study
Andreia Noites, Rita Nunes, Ana Isabel Gouveia, Alexandra Mota, Cristina Melo, Ágata Viera, Nuno Adubeiro, José Mesquita Bastos
The Journal of Alternative and Complementary Medicine.2015; 21(4): 229. CrossRef
Brain-derived neurotrophic factor correlated with muscle strength in subjects undergoing stationary bicycle exercise training
Sen-Wei Tsai, Yin-Ching Chan, Francois Liang, Chiann-Yi Hsu, I-Te Lee
Journal of Diabetes and its Complications.2015; 29(3): 367. CrossRef
Impact of Walking on Glycemic Control and Other Cardiovascular Risk Factors in Type 2 Diabetes: A Meta-Analysis
Shanhu Qiu, Xue Cai, Uwe Schumann, Martina Velders, Zilin Sun, Jürgen Michael Steinacker, Lamberto Manzoli
PLoS ONE.2014; 9(10): e109767. CrossRef
A systematic review and meta‐analysis of the effect of aerobic vs. resistance exercise training on visceral fat
I. Ismail, S. E. Keating, M. K. Baker, N. A. Johnson
Obesity Reviews.2012; 13(1): 68. CrossRef
The Effects of Regular Pilates Exercise on Blood pressure and Pulmonary Variables
Gyu-Chang Lee, Dong-Yeop Lee, Jae-Ho Yu
Journal of the Korea Academia-Industrial cooperation Society.2011; 12(7): 3088. CrossRef
The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
Kyung Wan Min
Journal of Korean Diabetes.2011; 12(1): 6. CrossRef
The Evaluation of Workplace Obesity Intervention Program using Six Sigma Methodology
Ji Yeon Kang, Ill Keun Park, Yun Kyun Chang, Sook Hee Sung, Yoo Kyoung Park, Sang Woon Cho, Yun Mi Paek, Tae In Choi
The Korean Journal of Obesity.2011; 20(4): 193. CrossRef
How Can We Measure the Effects of Exercise in Daily Life?
Sang Yong Kim
Korean Diabetes Journal.2010; 34(1): 21. CrossRef

Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients.: Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo Kyung Koo, Kyung Wan Min; Korean Diabetes J. 2009;33(6):511-517. Published online December 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.6.511

3,556 View
50 Download
4 Crossref

Abstract PDF

BACKGROUND
Combination fitness regimens (including aerobic and resistance exercises) are effective for improving cardio-respiratory fitness, reducing visceral fat and increasing insulin sensitivity in diabetic patients. The combination exercise intensity that a patient is capable of is limited by his or her aerobic capacity and one repetition maximum (1RM). We investigated the relationships between 1RM, aerobic exercise capacity and body mass index in patients with type 2 diabetes. METHODS: A total of 177 (men: 85, women: 92) diabetic subjects with HbA1c < or = 10% were enrolled. Muscle strength and 1RM were assessed bychest press (upper body) and leg press (lower body). We assessed aerobic capacity by VO2max and muscle mass by bioimpedance analysis. RESULTS: There was no correlation between 1RM and VO2max in type 2 diabetic patients (upper: P = 0.122, lower: P = 0.138 for men, and upper: P = 0.952, lower: P = 0.570 for women). However, 1RM was significantly correlated with muscle mass both in men and women (upper: r = 0.493, P < 0.001, r = 0.315, P = 0.002 lower: r = 0.437 P < 0.001, r = 0.307, P =0.003, respectively). There was also a significant correlation between 1RM and BMI. In obese male subjects with BMI > or = 25 kg/m2, we observed a significant correlation between muscle mass and BMI (r = 0.374, P = 0.032), but this correlation was not observed in women. CONCLUSION: Clinicians treating Korean type 2 diabetic subjects should recommend resistance exercise to their patients. In particular, obese women with diabetes may receive greater benefits by increasing muscle mass through resistance exercises.

Citations

Citations to this article as recorded by

Evaluation of Muscle Strength and Endurance in Postmenopausal Women: A Cross-sectional Study
Arati V Mahishale, Manali P Kulkarni
Journal of South Asian Federation of Obstetrics and Gynaecology.2021; 13(3): 163. CrossRef
The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
Diabetes & Metabolism Journal.2011; 35(4): 374. CrossRef
The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
Kyung Wan Min
Journal of Korean Diabetes.2011; 12(1): 6. CrossRef
The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
Korean Diabetes Journal.2010; 34(2): 101. CrossRef

Randomized Controlled Trial

Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus.: Yun Hyi Ku, Bo Kyung Koo, Hee Jung Ahn, Ji Yun Jeong, Hee Geum Seok, Ho Chul Kim, Kyung Ah Han, Kyung Wan Min; Korean Diabetes J. 2009;33(5):401-411. Published online October 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.5.401

4,872 View
81 Download
8 Crossref

Abstract PDF

BACKGROUND
Exercise offers protection against atherosclerosis and insulin resistance. We evaluated the benefits of exercise at different levels of intensity for ameliorating inflammation, endothelial dysfunction, and insulin resistance in a sample of type 2 diabetic subjects. METHODS: Fifty-nine overweight women with type 2 diabetes were randomly assigned to control (CG, N = 18), moderate-intensity exercise (MEG, N = 17), and vigorous-intensity exercise (VEG, N = 14) groups. Patients in the two experimental groups completed a 12-week exercise program, with their exercise activities monitored by accelerometers. We assessed the patients' body weights, total abdominal fat (TF), subcutaneous fat (SF) and visceral fat (VF) via computed tomography, measurements of plasma levels of hs-C-reactive protein (hs-CRP) and interleukin-6 (IL-6), assessment of endothelial function by brachial artery flow-mediated dilation (FMD), and evaluation of insulin sensitivity by insulin tolerance tests, at baseline, at the end of the 12-week interventions, and one year after initiation of the study. RESULTS: At baseline, the average age of all subjects was 54 +/- 7 years, and average body mass index (BMI) was 26.9 +/- 2.5 kg/m2. During the intervention, patients in the MEG and VEG groups expended comparable amounts of activity-related calories (488.6 +/- 111.9 kcal/day, 518.8 +/- 104.1 kcal/day, respectively). Although BMI, TF, and SF decreased similarly in the MEG and VEG groups (deltaBMI: -1.1 +/- 0.7, -0.8 +/- 0.5, deltaTF: -4,647 +/- 3,613 mm2, -2,577 +/- 2,872 mm2, deltaSF: -2,057 +/- 2,021 mm2, -1,141 +/- 1,825 mm2, respectively), compared to control (P<0.01), hs-CRP, IL-6, and FMD remained constant in both exercise groups even after completion of the 12-week exercise intervention. Insulin sensitivity improved only in patients subjected to vigorous exercise (VEG). Visceral fat loss was observed only in patients subjected to moderate exercise (MEG). At one-year follow up, these values had all returned to baseline. CONCLUSION: Exercise vigorous enough to result in significant weight and fat reduction did not ameliorate inflammation and endothelial dysfunction as measured at the end of a 12-week exercise intervention, nor did it result in sustained improvements in insulin sensitivity in type 2 diabetic subjects.

Citations

Citations to this article as recorded by

Effects of different exercise types on vascular endothelial function in individuals with abnormal glycaemic control: a systematic review and network meta-analysis
Zongxiang Li, Shengyao Luo, Xuebing Bai, Lu Huang, Hongyan Guo, Song Chen, Dan Wang
PeerJ.2025; 13: e19839. CrossRef
Different intensities of aerobic training for patients with type 2 diabetes mellitus and knee osteoarthritis: a randomized controlled trial
Chi Su, Lihua Huang, Shaochen Tu, Shengdi Lu
Frontiers in Endocrinology.2024;[Epub] CrossRef
The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis
Georgia Papagianni, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Constantinos Antonopoulos, Dimitrios Tachmatzidis, Triantafyllos Didangelos, Vaia Lambadiari, Nikolaos P.E. Kadoglou
Cytokine.2023; 164: 156157. CrossRef
Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials
Xiaoke Chen, Xinzheng Sun, Chenghao Wang, Hui He, Jos L. Quiles
Oxidative Medicine and Cellular Longevity.2020; 2020: 1. CrossRef
Effect of Diabetic Dietary Education Program on Diabetes Knowledge and Dietary Behaviors of Elderly Diabetic Patients
Ji Young Ye, Sung Hee Min, Min June Lee
Korean Journal of Food & Cookery Science.2017; 33(5): 601. CrossRef
Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
Acta Diabetologica.2016; 53(5): 769. CrossRef
Letter: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33(5):401-411, 2009)
Dong-Lim Kim
Korean Diabetes Journal.2009; 33(6): 547. CrossRef
Response: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33:(5)401-411, 2009)
Yun Hyi Ku, Bo-Kyung Koo, Kyung-Wan Min
Korean Diabetes Journal.2009; 33(6): 549. CrossRef

Original Article

Pedometer-Determined Physical Activity in Type 2 Diabetes in Korea.: Sang Ah Chang, Jung Min Lee, Tae Seo Sohn, Hyun Shik Son, Sung Woo Park, Sei Hyun Baik, Jae Myung Yu, Yeon Ah Sung, Chul Woo Ahn, Kyung Wan Min, Kyung Ah Han; Korean Diabetes J. 2007;31(1):83-88. Published online January 1, 2007; DOI: https://doi.org/10.4093/jkda.2007.31.1.83

2,544 View
25 Download

Abstract PDF: BACKGROUND
Walking is a popular, convenient and relatively safe form of exercise. However, there is few objective data for walking exercise. The aim of this study was to evaluate pedometer-determined physical activity defined as steps/day in type 2 diabetes mellitus. Therefore, it could be the basic data for programming walking exercise in diabetes mellitus. METHODS: Participants with type 2 diabetes who visited in 6 university hospitals on February, 2006 in Seoul and Kyung-gi area were recruited. The participants were asked their ambulatory activity with the given pedometer and calorimeter for 1 week. Total 240 (Male 122, Female 118) subjects who walked above 1000 steps/day were analyzed. We also collected their biochemical data from the medical records. RESULTS: Participants took 8532 +/- 4130 steps for day (step/day) and energy expenditure were 320 +/- 161 Cal/day. Steps/day was not significantly different between male and female, but energy expenditure was higher in male than female ( P < 0.05). Steps/day was significantly lower in obese patients than non-obese patients (P < 0.001). BMI (r = -0.325, P < 0.001), waist circumference (r = -0.287, P < 0.001), triglyceride (r = 0.164, P < 0.018) showed significant inverse correlation with steps/day, but BUN (r = 0.165, P = 0.019) and HDL-cholesterol (r = 0.164, P = 0.018) were positive correlated with steps/day significantly. BMI (r = -0.14, P < 0.032) and cholesterol (r = -0.139, P < 0.041) showed significantly inverse correlation with energy expenditure and BUN (r = 0.187, P = 0.008) and HDL cholesterol (r = 0.145, P < 0.037) positively correlated with energy expenditure. Pedometer-determined steps/day was positively associated with energy expenditure (r2 = 0.824, P < 0.001). CONCLUSION: This study showed the objective quantification of physical activity measured by simple and inexpensive pedometers. It could be used to recommend walking exercise since the practitioners can estimate steps/day for required energy expenditure.

Randomized Controlled Trial

The Effects of Aerobic Training Versus Resistance Training in Non-obese Type 2 Diabetics.: Keun Hee An, Kyung Wan Min, Kyung Ah Han; Korean Diabetes J. 2005;29(5):486-494. Published online September 1, 2005

2,164 View
90 Download

Abstract PDF: BACKGOUND: The purpose of this study was to explore the influence of the low intensity resistance exercise training and aerobic exercise training on body composition, physical fitness, and metabolic profiles in non-obese type 2 diabetic patients. METHODS: Participants(N:26) had been randomly assigned to resistance exercise(resistance, N:10), aerobic exercise(aerobic, N:9) and control group(control, N:7). Resistance exercise was carried out at 15~20RM(1RM 60%) and aerobic exercise was carried out at anaerobic threshold(AT). Each exercise group was scheduled to implement the training for twelve weeks, two times per day and five days per week. RESULTS: Body mass index, waist to hip ratio, %fat, FBS, PP2, HbA1c and low-density lipoprotein cholesterol(LDL-C) were significantly decreased after the training period in resistance and aerobic exercise group. Strength endurance, agility and flexibility were significantly improved after the training period in resistance and aerobic exercise groups. There were significant differences in BMI, percent fat, FBS, PP2, METs and HR at anaerobic threshold after the training period in aerobic and control groups. Total cholesterol was significantly decreased after the training period in aerobic exercise groups. Load, heart rate and METs at AT significantly increased after the training period in aerobic group. High-density lipoprotein cholesterol(HDL-C) and balance significantly increased after the training period in resistance group. There were significant differences in strength endurance and agility between two exercise groups and control group. CONCLUSION: This study suggested circuit type resistance exercise might have nearly comparable effects on weight control, body composition, blood glucose control and improvement of insulin resistance in non-obese type 2diabetic patients.

Original Articles

The Long-term Effect of a Structured Diabetes Education Program for Uncontrolled Type 2 Diabetes Mellitus Patients-a 4-Year Follow-up.: Min Sun Song, Ki Ho Song, Seung Hyun Ko, Yu Bai Ahn, Joon Sung Kim, Jin Hee Shin, Yang Kyung Cho, Kun Ho Yoon, Bong Youn Cha, Ho Young Son, Dong Han Lee; Korean Diabetes J. 2005;29(2):140-150. Published online March 1, 2005

2,106 View
75 Download

Abstract PDF: BACKGROUND
Diabetes mellitus is a chronic illness with many metabolic complications. The prevalence of diabetes mellitus has markedly increased. Until now, however, little data have been presented for the long-term evaluation of a structured diabetes education program (SDEP) for patients with type 2 diabetes mellitus. The aim of this study was to examine the effects of the SDEP on glycemic control, lipid profiles, and self-care behavior over a four-year follow-up period. METHODS: A total of 248 diabetic patients completed the SDEP from December 1999 to September 2000. Ninety-eight patients were followed-up for more than four years and 75 of them were selected for the study, after those subjects having a baseline glycated hemoglobin(HbA1c) levels below 7.9% were excluded. The laboratory data included the glycemic control status(fasting blood sugar and HbA1c), serum creatinine, and lipid profiles. Compliance with their diet, self monitoring of blood glucose, and their exercise frequency were monitored with a questionnaire that was completed by the patients when they visited the hospital. The data were analyzed by using repeated ANOVA measures and chi2 testing for detecting trends. RESULTS: There were no significant decreases in the fasting blood glucose, creatinine, total cholesterol, triglycerides or low density lipoprotein cholesterol for the SDEP group compared with the control group. The self-care behavior of the SDEP group was much better than that of the control group and it was well maintained. Although the self-care behavior tended to deteriorate with time in the SDEP group, the exercise frequency did not change. The HbA1c level was much improved in the SDEP group(HbA1c: SDEP, 7.9+/-1.2% vs. 8.9+/-1.6% for the control; P =0.009). High density lipoprotein(HDL) cholesterol was also relatively improved in the SDEP group(HDL cholesterol: SDEP, 1.1+/-0.2 mmol/L vs. 1.0+/-0.3mmol/L for the control; P=0.006). CONCLUSIONS: The glycemic control status of diabetic patients who undertook the SDEP was satisfactory for one year after the program, although all the habitual compliance measures decreased gradually with time over the total four years. These results demonstrate that the SDEP for patients with diabetes is useful in improving their long-term glycemic control and self-care behavior. Regular and sustained reinforcement with encouragement will be required for the diabetic patients to maintain their self-care

Maximal Oxygen Uptake (VO2max) and Metabolic Syndrome.: Mira Kang, Ji Dong Sung, Byung Chul Yoo, Yoon Ho Choi, Sae Young Jae, Jae Hoon Chung, Yong Ki Min, Myung Shik Lee, Kwang Won Kim, Moon Kyu Lee; Korean Diabetes J. 2005;29(1):65-71. Published online January 1, 2005

2,334 View
50 Download

Abstract PDF: BACKGROUND
A number of studies have demonstrated an inverse relationship between cardiorespiratory fitness and metabolic syndrome. However, whether the maximal oxygen uptake (VO2max) is dependent on the number of metabolic components or on particular metabolic component remains to be assessed. METHODS: A total of 1,432 Korean subjects were studied. Each individual was assessed for the presence of metabolic syndrome using the modified NCEP-ATP III criteria. All subjects underwent a graded symptom-limited maximal exercise test to determine their VO2max, using a treadmill according to the Bruce protocol. RESULTS: The age-adjusted prevalence of metabolic syndrome in all subjects was 20.4%. The odds ratios for metabolic syndrome were higher in men, the elderly, the obese and those with a lower VO2max. The difference in the VO2max was dependent only on the presence of metabolic syndrome, not on the number of components. CONCLUSION: There were no significant differences in the VO2max according to the presence of particular metabolic components. These results suggest that the VO2max reflects the metabolic syndrome state, rather than the metabolic components, and might be a factor in determining metabolic syndrome

Exercise and Fenofibrate Reduces Body Adiposity Synergistically in OLETF Rats.: Young Jun An, Hre Jeong Lee, Mi Kyoung Park, Kyung Il Lee, In Young Koh, Dong Sik Jung, Ah Young Kang, Duk Kyu Kim; Korean Diabetes J. 2004;28(2):131-138. Published online April 1, 2004

1,541 View
19 Download

Abstract PDF: BACKGROUND
The PPAR alpha activator, Fenofibrate, is a pharmacological ligand, which induces beta-oxidation of long chain fatty acids in the mitochondria of hepatocytes. The beta-oxidation induced by exogenous PPAR alpha activators may be operated maximally when the sustained production of energy substrate in the liver is required by working muscles due to continued exercise. The aim of this study was to determine whether the combination therapy of exercise and Fenofibrate could synergistically reduce body adiposity in OLETF rats. METHODS: Twenty-eight male OLETF rats(13 wk old) were divided into four groups. The diet(n=7) and exercise groups(n=7) were fed with chow for 12 weeks. The Fenofibrate(n=7) and combined treatment(exercise and Fenofibrate) groups (n=7) were fed with Fenofibrate(32mg/kg/day) mixed chow for 12 weeks. The animals in the exercise and combined treatment groups were exercised by running on a treadmill for 12 weeks. At 24 weeks of age, all the rats were sacrificed, and examined by biochemical tests and had their adipose tissue weight measured. RESULTS: There were no significant changes in the retroperitoneal and subcutaneous fats between the diet and Fenofibrate groups, but there were between the diet and combined treatment groups(P<0.05). CONCLUSION: Exercise combined with Fenofibrate synergistically reduces body adiposity in OLETF rats

Clinical Characteristics of Diabetic Patients Controlled by Diet and Exercise.: Kil Sang Wang, Sung Bae Lee, Hyun Suk Lee, Jae Suk Jeon, Kyung Wan Min, Kyung Ah Han, Eung Jin Kim; Korean Diabetes J. 1999;23(1):98-107. Published online January 1, 2001

1,395 View
20 Download

Abstract PDF: BACKGROUND
In order to rnaintain blood glucose in ao acceptable range, some patients with type 2 diabetes mellitus may be able to their level manage with diet and exercise alone, but others require oral agents or insulin. To assess which factors gave important influences on therapeutic methocls, we investigated clinical characteristics and life-style in the type 2 diabetic patients who could be managed with diet and exercise alone. METHODS: We recruited patients with type 2 diabetes mellitus from Eulji Medical College Diabetes Center, who had dieted and exercised for over 3 years (99; group 1) and compared them with patients who were managed with oral agents (130; group 2) or insulin (47; group 3). We conducted the retrospective evaluation of age, sex, duration of DM, initial and recent BM1 (body mass index), serial HbA 1c, skipped period ratio of hospital follow-up, self monitoring of blood glucose (SMBG) or urine sugar, diet and exercise and educational chance for diabetes with dependency of folk remedies. RESULTS: The duration of the DM was significantly shorter in group 1 than in group 2 or 3 (p<0,05). Initial BMI and HbA. were not different among these three groups, but HMI reduction was more decreased in group 1 (p<0.05). The mean HbA, during follow-up was lower in group 1 (p<0.05). The skipped period ratio of hospital follow-up was lower in group 1 (p<0.05). SMBG was less frequent, the meal-time was more regular, extra-snacks were less frequent and folk remedies were rarely tried in group 1. CONCLUSION: This study suggests that the duration of DM, BMI reduction and mean HbA 1c, were associated with the therapeutic method in patients with type 2 diabetes mellitus. We would like to a]so emphasize the importance of SMBG, meal-time regularity, extra-snacks and folk remedies in the education of patients with type 2 diabetes mellitus.

Effect of Exercise Training on Insulin Sensitivity and Intracellular Glucose Metabolism in Skeletal Muscle of High Fat-fed Rats.: Chul Hee Kim, Joong Yeol Park, Sung Kwan Hong, Kyong Soo Park, Hong Kyu Lee, Ki Up Lee; Korean Diabetes J. 1998;22(2):231-242. Published online January 1, 2001

1,769 View
18 Download

Abstract PDF: BACKGROUND
Insulin resistance is a major characteristic of non-insulin-dependent diabetes mellitus and obesity. Many studies have indicated that increased intake of fat are associated with obesity and insulin resistance. On the other hand, chronic exercise is known to improve insulin sensitivity. However, the mechanisms by which high fat diet induces insulin resistance and exercise trainmg improves insulin sensitivity are not established. This study was undertaken to examine the mechanisms by which high fat diet and exercise training affect the insulin sensitivity in the whole body and in skeletal muscles. METHODS: Male Sprague-Dawley rats were divided into three groups: high fat sedentary group, high fat exercise group, and control(low fat sedentary) group. High fat diet consists of 66.5% fat and 12.5% carbohydrate, and control(low fat) diet consists of 12 5% fat and 66.5% carbohydrate. Exercise training was performed by swimming three hours per day. After 3 weeks, animals underwent hyperinsulinemic euglycemic clamp study to measure whole body glucose metabolic fluxes. Glycogen synthase activity and glucose-6-phosphate (G-6-P) levels were measured in skeletal muscle at the end of the clamp study. RESULTS: In the high fat diet group, whole body glycolysis and glycogen synthesis were decreased. Exercise training reversed the insulin resistance induced by high fat diet by increasing both glycolysis and glycogen synthesis. Glycogen synthase activity in skeletal muscle was reduced in high fat diet group, and it was partially reversed by exercise training. G-6-P level in skeletal muscle was increased in high fat diet group, and it was further increased by exercise training. CONCLUSION: These results suggested that the insulin resistance in high fat diet-fed rats is due to the impairment in glucose metabolism at sites distal to G-6-P, i.e. glycolysis and glycogen synthesis. In contrast, the improvement in insulin sensitivity by exercise training in high fat-fed rats is primarily due to the increased glucose metabolic flux proximal to G-6-P, i.e. glucose transport and phosphorylation.

First
Prev
Page of 1
Next
Last

Search