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3 "Epidermal growth factor"
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Brief Report
Serum Soluble Epidermal Growth Factor Receptor Level Increase in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
Ji Min Kim, Sorim Choung, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Diabetes Metab J. 2018;42(4):343-347.   Published online May 2, 2018
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  • 6 Web of Science
  • 5 Crossref
AbstractAbstract PDFPubReader   

We analyzed circulating soluble epidermal growth factor receptor (sEGFR) levels in humans. Serum sEGFR levels were higher in subjects with newly diagnosed type 2 diabetes mellitus compared with controls. Serum sEGFR was positively correlated with glycosylated hemoglobin and serum glucose and negatively correlated with serum insulin and C-peptide levels.


Citations to this article as recorded by  
  • Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus
    Xiang Kong, Shu-jun Wan, Tian-bing Chen, Lan Jiang, Yu-jie Xing, Ya-ping Bai, Qiang Hua, Xin-ming Yao, Yong-li Zhao, Hong-mei Zhang, De-guo Wang, Qing Su, Kun Lv
    Cellular & Molecular Biology Letters.2024;[Epub]     CrossRef
  • A Pilot Genome-Wide Association Study Identifies Novel Markers of Metabolic Syndrome in Patients with Psoriasis
    Seung-Min Oh, Su-Kang Kim, Hye-Jin Ahn, Ki-Heon Jeong
    Annals of Dermatology.2023; 35(4): 285.     CrossRef
  • Effect of cholesterol-lowering agents on soluble epidermal growth factor receptor level in type 2 diabetes and hypercholesterolemia
    Jun Choul Lee, Kyong Hye Joung, Ji Min Kim, Seon Mee Kang, Hyun Jin Kim, Bon Jeong Ku
    Medicine.2022; 101(34): e30287.     CrossRef
  • Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects
    Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Yu Togashi, Ryota Inoue, Jinghe Li, Daisuke Miyashita, Yasuo Terauchi
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Epidermal growth factor protects against myocardial ischaemia reperfusion injury through activating Nrf2 signalling pathway
    Jun Ma, Ge Jin
    Free Radical Research.2019; 53(3): 313.     CrossRef
Original Articles
Comparison of EGF with VEGF Non-Viral Gene Therapy for Cutaneous Wound Healing of Streptozotocin Diabetic Mice
Junghae Ko, Haejung Jun, Hyesook Chung, Changshin Yoon, Taekyoon Kim, Minjeong Kwon, Soonhee Lee, Soojin Jung, Mikyung Kim, Jeong Hyun Park
Diabetes Metab J. 2011;35(3):226-235.   Published online June 30, 2011
  • 4,774 View
  • 35 Download
  • 20 Crossref
AbstractAbstract PDFPubReader   

To accelerate the healing of diabetic wounds, various kinds of growth factors have been employed. It is the short half-life of administered growth factors in hostile wound beds that have limited wide-spread clinical usage. To overcome this limitation, growth factor gene therapy could be an attractive alternative rather than direct application of factors onto the wound beds. We administered two growth factor DNAs, epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) into a cutaneous wound on diabetic mice. We compared the different characteristics of the healing wounds.


Streptozotocin was injected intraperitoneally to induce diabetes into C57BL/6J mice. The ultrasound micro-bubble destruction method with SonoVue as a bubbling agent was used for non-viral gene delivery of EGF828 and VEGF165 DNAs. Each gene was modified for increasing efficacy as FRM-EGF828 or minicircle VEGF165. The degree of neoangiogenesis was assessed using qualitative laser Doppler flowmetry. We compared wound size and histological findings of the skin wounds in each group.


In both groups, accelerated wound closure was observed in the mice receiving gene therapy compared with non treated diabetic control mice. Blood flow detected by laser doppler flowmetry was better in the VEGF group than in the EGF group. Wound healing rates and histological findings were more accelerated in the EGF gene therapy group than the VEGF group, but were not statistically significant.


Both non-viral EGF and VEGF gene therapy administrations could improve the speed and quality of skin wound healing. However, the detailed histological characteristics of the healing wounds were different.


Citations to this article as recorded by  
  • Gene therapy to enhance angiogenesis in chronic wounds
    Elnaz Shaabani, Maryam Sharifiaghdam, Reza Faridi-Majidi, Stefaan C. De Smedt, Kevin Braeckmans, Juan C. Fraire
    Molecular Therapy - Nucleic Acids.2022; 29: 871.     CrossRef
  • Approaches to Modulate the Chronic Wound Environment Using Localized Nucleic Acid Delivery
    Adam G. Berger, Jonathan J. Chou, Paula T. Hammond
    Advances in Wound Care.2021; 10(9): 503.     CrossRef
  • Limited Treatment Options for Diabetic Wounds: Barriers to Clinical Translation Despite Therapeutic Success in Murine Models
    May Barakat, Luisa A. DiPietro, Lin Chen
    Advances in Wound Care.2021; 10(8): 436.     CrossRef
  • Minicircle‐based expression of vascular endothelial growth factor in mesenchymal stromal cells from diverse human tissues
    Joana Serra, Cláudia P. A. Alves, Joaquim M. S. Cabral, Gabriel A. Monteiro, Cláudia L. da Silva, Duarte Miguel F. Prazeres
    The Journal of Gene Medicine.2021;[Epub]     CrossRef
  • Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
    S. Michaela Rikard, Paul J. Myers, Joachim Almquist, Peter Gennemark, Anthony C. Bruce, Maria Wågberg, Regina Fritsche-Danielson, Kenny M. Hansson, Matthew J. Lazzara, Shayn M. Peirce
    Cellular and Molecular Bioengineering.2021; 14(4): 321.     CrossRef
  • β-Neoendorphin Enhances Wound Healing by Promoting Cell Migration in Keratinocyte
    Dong Joo Yang, Sang Hyun Moh, Yun-Hee Choi, Ki Woo Kim
    Molecules.2020; 25(20): 4640.     CrossRef
  • Orf Virus IL-10 and VEGF-E Act Synergistically to Enhance Healing of Cutaneous Wounds in Mice
    Lyn M. Wise, Gabriella S. Stuart, Nicola C. Jones, Stephen B. Fleming, Andrew A. Mercer
    Journal of Clinical Medicine.2020; 9(4): 1085.     CrossRef
  • Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor–Encoding Minicircles for AngiogenicEx VivoGene Therapy
    Joana Serra, Cláudia P.A. Alves, Liliana Brito, Gabriel A. Monteiro, Joaquim M.S. Cabral, Duarte Miguel F. Prazeres, Cláudia L. da Silva
    Human Gene Therapy.2019; 30(3): 316.     CrossRef
  • Therapeutic strategies for enhancing angiogenesis in wound healing
    Austin P. Veith, Kayla Henderson, Adrianne Spencer, Andrew D. Sligar, Aaron B. Baker
    Advanced Drug Delivery Reviews.2019; 146: 97.     CrossRef
  • Nanomedicines and gene therapy for the delivery of growth factors to improve perfusion and oxygenation in wound healing
    Céline M. Desmet, Véronique Préat, Bernard Gallez
    Advanced Drug Delivery Reviews.2018; 129: 262.     CrossRef
  • Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications
    Mulugeta Gizaw, Jeffrey Thompson, Addison Faglie, Shih-Yu Lee, Pierre Neuenschwander, Shih-Feng Chou
    Bioengineering.2018; 5(1): 9.     CrossRef
  • Non-viral gene therapy: Gains and challenges of non-invasive administration methods
    Marianna Foldvari, Ding Wen Chen, Nafiseh Nafissi, Daniella Calderon, Lokesh Narsineni, Amirreza Rafiee
    Journal of Controlled Release.2016; 240: 165.     CrossRef
  • RETRACTED ARTICLE: Decellularized scaffolds containing hyaluronic acid and EGF for promoting the recovery of skin wounds
    Zhengzheng Wu, Yan Tang, Hongdou Fang, Zhongchun Su, Bin Xu, Yongliang Lin, Peng Zhang, Xing Wei
    Journal of Materials Science: Materials in Medicine.2015;[Epub]     CrossRef
  • Acute and chronic wound fluids inversely influence adipose‐derived stem cell function: molecular insights into impaired wound healing
    Paola Koenen, Timo A Spanholtz, Marc Maegele, Ewa Stürmer, Thomas Brockamp, Edmund Neugebauer, Oliver C Thamm
    International Wound Journal.2015; 12(1): 10.     CrossRef
  • Adipose‐derived stem cells and keratinocytes in a chronic wound cell culture model: the role of hydroxyectoine
    Oliver C Thamm, Panagiotis Theodorou, Ewa Stuermer, Max J Zinser, Edmund A Neugebauer, Paul C Fuchs, Paola Koenen
    International Wound Journal.2015; 12(4): 387.     CrossRef
  • Genetic and cellular techniques emerge as promising modalities for the treatment of diabetic foot syndrome
    Vladimir Iosifovich Konenkov, Vadim Valerievich Klimontov
    Diabetes mellitus.2014; 17(1): 63.     CrossRef
  • Analysis of blood flow and local expression of angiogenesis-associated growth factors in infected wounds treated with negative pressure wound therapy
    Molecular Medicine Reports.2014; 9(5): 1749.     CrossRef
  • Alteration of Skin Properties with Autologous Dermal Fibroblasts
    Rajesh Thangapazham, Thomas Darling, Jon Meyerle
    International Journal of Molecular Sciences.2014; 15(5): 8407.     CrossRef
  • Angiopoietin-like 4 Stimulates STAT3-mediated iNOS Expression and Enhances Angiogenesis to Accelerate Wound Healing in Diabetic Mice
    Han Chung Chong, Jeremy Soon Kiat Chan, Chi Qin Goh, Natalia V Gounko, Baiwen Luo, Xiaoling Wang, Selin Foo, Marcus Thien Chong Wong, Cleo Choong, Sander Kersten, Nguan Soon Tan
    Molecular Therapy.2014; 22(9): 1593.     CrossRef
  • Genome Editing of Mouse Fibroblasts by Homologous Recombination for Sustained Secretion of PDGF-B and Augmentation of Wound Healing
    Jenny C. Barker, Adam D. Barker, Jessica Bills, Jiying Huang, Mary Wight-Carter, Imelda Delgado, Debby L. Noble, Lily J. Huang, Matthew H. Porteus, Kathryn E. Davis
    Plastic and Reconstructive Surgery.2014; 134(3): 389e.     CrossRef
Cloning of Novel Epidermal Growth Factor (EGF) Plasmid for Gene Therapy on Diabetic Foot Ulcer.
Hye Sook Chung, Chang Shin Yoon, Min Jeong Kwon, Mi Kyung Kim, Soon Hee Lee, Kyung Soo Ko, Byung Doo Rhee, Jeong Hyun Park
Korean Diabetes J. 2008;32(2):131-140.   Published online April 1, 2008
  • 1,910 View
  • 44 Download
  • 1 Crossref
AbstractAbstract PDF
Epidermal Growth Factor (EGF) is one of the important growth factors involved in the epithelialization during cutaneous wound healing. Peptide EGF has been used for the treatment of diabetic foot ulcer. But the inferiority of cost-effectiveness and the inconvenience of daily application might have restricted its wide clinical usage. EGF gene therapy could dramatically improve the efficacy and inconvenience through long-term expression and bypassing the EGF degradation by hostile non-specific proteinases expressed in the wound bed. METHODS: EGF DNAs were amplified via PCR. For the more effective secretion from the transfected cell, we inserted furin cleavage site into EGF plasmids. The efficacy of novel plasmid pbeta-EGF was verified by transfection into the various animal cell lines, and the biologic potency of expressed EGF was confirmed via phosphorylation of PI3K and GSK3beta by Western blotting. RESULTS: We tested various kinds of human EGFs. One of the human EGF isoforms, EGF(828) including a membrane-anchoring domain was successfully released as the mature EGF protein in the cell culture media. Also EGF plasmid including furin cleavage site showed more than 2-fold increased EGF expression compared with the sequence without furin cleavage site. CONCLUSION: In conclusion, these findings suggest that mature EGF could be released easily out of cells by modifying EGF DNA sequence. Our novel EGF plasmid DNA could markedly increase the efficiency of non-viral gene therapy for diabetic foot ulcer.


Citations to this article as recorded by  
  • Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer
    Min J. Kwon, Songhie An, Sunghyun Choi, Kihoon Nam, Hye S. Jung, Chang S. Yoon, Jung H. Ko, Hye J. Jun, Tae K. Kim, Soo J. Jung, Jeong H. Park, Yan Lee, Jong‐Sang Park
    The Journal of Gene Medicine.2012; 14(4): 272.     CrossRef

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