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Clinical Diabetes & Therapeutics
Diabetes and Subclinical Coronary Atherosclerosis
Chang Hoon Lee, Seung-Whan Lee, Seong-Wook Park
Diabetes Metab J. 2018;42(5):355-363.   Published online October 22, 2018
DOI: https://doi.org/10.4093/dmj.2018.0041
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  • 13 Web of Science
  • 11 Crossref
AbstractAbstract PDFPubReader   

It is well known that diabetic patients have a high risk of cardiovascular events, and although there has been a tremendous effort to reduce these cardiovascular risks, the incidence of cardiovascular morbidity and mortality in diabetic patients remains high. Therefore, the early detection of coronary artery disease (CAD) is necessary in those diabetic patients who are at risk of cardiovascular events. Significant medical and radiological advancements, including coronary computed tomography angiography (CCTA), mean that it is now possible to investigate the characteristics of plaques, instead of solely evaluating the calcium level of the coronary artery. Recently, several studies reported that the prevalence of subclinical coronary atherosclerosis (SCA) is higher than expected, and this could impact on CAD progression in asymptomatic diabetic patients. In addition, several reports suggest the potential benefit of using CCTA for screening for SCA in asymptomatic diabetic patients, which might dramatically decrease the incidence of cardiovascular events. For these reasons, the medical interest in SCA in diabetic patients is increasing. In this article, we sought to review the results of studies on CAD in asymptomatic diabetic patients and discuss the clinical significance and possibility of using CCTA to screen for SCA.

Citations

Citations to this article as recorded by  
  • Coronary Artery Calcium Score directed risk stratification of patients with Type-2 diabetes mellitus
    Mahmoud Nassar, Nso Nso, Kelechi Emmanuel, Mohsen Alshamam, Most Sirajum Munira, Anoop Misra
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(6): 102503.     CrossRef
  • Association between carotid atherosclerosis and presence of intracranial atherosclerosis using three-dimensional high-resolution vessel wall magnetic resonance imaging in asymptomatic patients with type 2 diabetes
    Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, Geon-Ho Jahng, Soonchan Park, In-Kyung Jeong, Chang-Woo Ryu
    Diabetes Research and Clinical Practice.2022; 191: 110067.     CrossRef
  • Serum metabolic signatures of subclinical atherosclerosis in patients with type 2 diabetes mellitus: a preliminary study
    Jiaorong Su, Qing Zhao, Aihua Zhao, Wei Jia, Wei Zhu, Jingyi Lu, Xiaojing Ma
    Acta Diabetologica.2021; 58(9): 1217.     CrossRef
  • Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease
    Yueqiao Si, Wenjun Fan, Chao Han, Jingyi Liu, Lixian Sun
    The American Journal of the Medical Sciences.2021; 362(3): 285.     CrossRef
  • Cardiologist's approach to the diabetic patient: No further delay for a paradigm shift
    Francesco Maranta, Lorenzo Cianfanelli, Carlo Gaspardone, Vincenzo Rizza, Rocco Grippo, Marco Ambrosetti, Domenico Cianflone
    International Journal of Cardiology.2021; 338: 248.     CrossRef
  • Co‐expression of glycosylated aquaporin‐1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis‐prone mice
    Rosalinda Madonna, Vanessa Doria, Anikó Görbe, Nino Cocco, Péter Ferdinandy, Yong‐Jian Geng, Sante Donato Pierdomenico, Raffaele De Caterina
    Journal of Cellular and Molecular Medicine.2020; 24(5): 2857.     CrossRef
  • Recent Updates on Vascular Complications in Patients with Type 2 Diabetes Mellitus
    Chan-Hee Jung, Ji-Oh Mok
    Endocrinology and Metabolism.2020; 35(2): 260.     CrossRef
  • Quantitative measure of asymptomatic cardiovascular disease risk in Type 2 diabetes: Evidence from Indian outpatient setting
    Samit Ghosal, Binayak Sinha, Jignesh Ved, Mansij Biswas
    Indian Heart Journal.2020; 72(2): 119.     CrossRef
  • Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: a literature review
    Vitaris Kodogo, Feriel Azibani, Karen Sliwa
    Clinical Research in Cardiology.2019; 108(8): 831.     CrossRef
  • Letter: Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2019;43:582–9)
    Tae Seo Sohn
    Diabetes & Metabolism Journal.2019; 43(6): 909.     CrossRef
  • Effects of Diabetes on Motor Recovery After Cerebral Infarct: A Diffusion Tensor Imaging Study
    Jun Sung Moon, Seung Min Chung, Sung Ho Jang, Kyu Chang Won, Min Cheol Chang
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(9): 3851.     CrossRef
Original Article
Matrix Metalloproteinase-3 Gene Polymorphism is Associated with Coronary Artery Calcification Scores in Patients with Type 2 Diabetes Mellitus.
Sang Wook Kim, Eun Hee Cho
Korean Diabetes J. 2009;33(2):113-123.   Published online April 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.2.113
  • 2,150 View
  • 20 Download
AbstractAbstract PDF
BACKGROUND
Matrix metalloproteinase-3 (MMP-3) is expressed in human coronary atherosclerotic lesions and is known to be involved in the degradation of plaque. This study examines the association of MMP-3 gene promoter 5A/6A and -709A>G polymorphisms with coronary artery calcium scores in type 2 diabetes patients. METHODS: The study comprises 140 type 2 diabetes patients aged 34~85 years, who showed no evidence of clinical cardiovascular disease before recruitment. Recruitment was based on patient's coronary artery calcium (CAC) scores and polymorphisms were identified. RESULTS: Multiple regression analysis showed that the CAC scores were significantly associated with age (P = 0.008), waist circumference (P = 0.03), duration of diabetes (P = 0.003) and the serum creatinine level (P = 0.012). MMP-3 5A/6A and -709A>G polymorphisms were not associated with CAC across all subjects. However, in the subgroup with a duration of diabetes over 10 years, MMP-3 -709A>G were significantly associated with CAC (P = 0.037) adjusted for age, body mass index, waist circumference and duration of diabetes. CONCLUSION: Our data suggest that the CAC scores in patients with type 2 diabetes were related with age, waist circumference, duration of diabetes and higher serum creatinine levels. MMP-3 polymorphisms with -709A>G are associated with high CAC in patients with a duration of diabetes over 10 years.

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