Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
5 "Biological markers"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
GDF15 Is a Novel Biomarker for Impaired Fasting Glucose
Jun Hwa Hong, Hyo Kyun Chung, Hye Yoon Park, Kyong-Hye Joung, Ju Hee Lee, Jin Gyu Jung, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong
Diabetes Metab J. 2014;38(6):472-479.   Published online December 15, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.6.472
  • 5,800 View
  • 78 Download
  • 69 Web of Science
  • 64 Crossref
AbstractAbstract PDFPubReader   
Background

Growth differentiation factor-15 (GDF15) is a protein that belongs to the transforming growth factor β superfamily. An elevated serum level of GDF15 was found to be associated with type 2 diabetes mellitus (T2DM). T2DM is an inflammatory disease that progresses from normal glucose tolerance (NGT) to impaired fasting glucose (IFG). Hence, we aimed to validate the relationship between GDF15 and IFG.

Methods

The participants were divided into the following three groups: NGT (n=137), IFG (n=29), and T2DM (n=75). The controls and T2DM outpatients visited the hospital for routine health check-ups. We used fasting blood glucose to detect IFG in nondiabetic patients. We checked the body mass index (BMI), C-reactive protein level, metabolic parameters, and fasting serum GDF15 level.

Results

Age, BMI, triglyceride, insulin, glucose, homeostatic model assessment-insulin resistance (HOMA-IR), and GDF15 levels were elevated in the IFG and T2DM groups compared to the NGT group. In the correlation analysis between metabolic parameters and GDF15, age and HOMA-IR had a significant positive correlation with GDF15 levels. GDF15 significantly discriminated between IFG and NGT, independent of age, BMI, and HOMA-IR. The serum levels of GDF15 were more elevated in men than in women. As a biomarker for IFG based on the receiver operating characteristic curve analysis, the cutoff value of GDF15 was 510 pg/mL in males and 400 pg/mL in females.

Conclusion

GDF15 had a positive correlation with IR independent of age and BMI, and the serum level of GDF15 was increased in the IFG and T2DM groups. GDF15 may be a novel biomarker for detecting IFG in nondiabetic patients.

Citations

Citations to this article as recorded by  
  • Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes
    Michael M Richter, Mads N Thomsen, Mads J Skytte, Sasha A S Kjeldsen, Amirsalar Samkani, Jan Frystyk, Faidon Magkos, Jens J Holst, Sten Madsbad, Thure Krarup, Steen B Haugaard, Nicolai J Wewer Albrechtsen
    Journal of the Endocrine Society.2024;[Epub]     CrossRef
  • Serum Growth Differentiation Factor 15 Levels Predict the Incidence of Frailty among Patients with Cardiometabolic Diseases
    Kazuhito Oba, Joji Ishikawa, Yoshiaki Tamura, Yasunori Fujita, Masafumi Ito, Ai Iizuka, Yoshinori Fujiwara, Remi Kodera, Kenji Toyoshima, Yuko Chiba, Masashi Tanaka, Atsushi Araki
    Gerontology.2024; 70(5): 517.     CrossRef
  • Growth differentiation factor 15 and malnutrition in older adults
    Nazanin Rostami, Blanca Fabre-Estremera, Antonio Buño-Soto, José R Banegas, Fernando Rodríguez-Artalejo, Rosario Ortolá
    The Journal of nutrition, health and aging.2024; 28(6): 100230.     CrossRef
  • Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly
    Busra Firlatan, Ugur Nadir Karakulak, Vedat Hekimsoy, Burcin Gonul Iremli, Incilay Lay, Deniz Yuce, Selcuk Dagdelen, Giray Kabakci, Tomris Erbas
    Hormones.2024;[Epub]     CrossRef
  • Nausea, vomiting and conflict in pregnancy
    Bernard J Crespi
    Evolution, Medicine, and Public Health.2024; 12(1): 75.     CrossRef
  • Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
    Yaser Khajebishak, Amir Hossein Faghfouri, Ali Soleimani, Sadra Madani, Laleh Payahoo
    Hormone Molecular Biology and Clinical Investigation.2023; 44(2): 127.     CrossRef
  • Relationship between meteorin-like peptide (Metrnl) serum levels and inflammatory cytokines, oxidative stress biomarkers and body composition parameters in type 2 diabetes patients
    Yaser Khajebishak, Sadra Madani, Amir Hossein Faghfouri, Ali Soleimani, Sara Ilaei, Said Peyrovi, Laleh Payahoo
    Nutrition & Food Science.2023; 53(5): 861.     CrossRef
  • Effects of acute exercise and exercise training on plasma GDF15 concentrations and associations with appetite and cardiometabolic health in individuals with overweight or obesity – A secondary analysis of a randomized controlled trial
    Jonas Salling Quist, Anders Bue Klein, Kristine Færch, Kristine Beaulieu, Mads Rosenkilde, Anne Sofie Gram, Anders Sjödin, Signe Torekov, Bente Stallknecht, Christoffer Clemmensen, Martin Bæk Blond
    Appetite.2023; 182: 106423.     CrossRef
  • Significant increase of serum extracellular vesicle-packaged growth differentiation factor 15 in type 2 diabetes mellitus: a cross-sectional study
    Wen Zhao, Xinwei Li, Xinxin Li, Lu Peng, Yu Li, Yunhui Du, Jianxun He, Yanwen Qin, Huina Zhang
    European Journal of Medical Research.2023;[Epub]     CrossRef
  • Association between growth differentiation factor 15 levels and gestational diabetes mellitus: A combined analysis
    Yi-Cheng Lu, Song-Liang Liu, Yu-Shan Zhang, Fei Liang, Xiao-Yan Zhu, Yue Xiao, Jing Wang, Cong Ding, Sudipta Banerjee, Jie-Yun Yin, Qiu-Ping Ma
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight
    Song-Yang Zhang, Kyla Bruce, Zahra Danaei, Rosa J.W. Li, Daniel R. Barros, Rachel Kuah, Yu-Mi Lim, Laura H. Mariani, David Z. Cherney, Jennifer F.M. Chiu, Heather N. Reich, Tony K.T. Lam
    Cell Metabolism.2023; 35(5): 875.     CrossRef
  • Growth differentiation factor 15 (GDF-15) in endocrinology
    Pedro Iglesias, Ramona A. Silvestre, Juan J. Díez
    Endocrine.2023; 81(3): 419.     CrossRef
  • Identification of biomarkers for glycaemic deterioration in type 2 diabetes
    Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, A
    Nature Communications.2023;[Epub]     CrossRef
  • Metabolic syndrome and Growth Differentiation Factor 15 in older adults
    Adrián Carballo-Casla, Esther García-Esquinas, Antonio Buño-Soto, Ellen A. Struijk, Esther López-García, Fernando Rodríguez-Artalejo, Rosario Ortolá
    GeroScience.2022; 44(2): 867.     CrossRef
  • Associations between GDF15 Levels and Pre-Diabetes in Non-Obese Subjects
    Hao-Chang Hung, Hung-Tsung Wu, Ching-Han Lin, Hsuan-Wen Chou, Horng-Yih Ou, Chih-Jen Chang
    Journal of Investigative Medicine.2022; 70(1): 79.     CrossRef
  • Growth Differentiation Factor-15 as a Biomarker of Obese Pre-diabetes and Type 2 Diabetes Mellitus in Indian Subjects: A Case-control Study
    Dipayan Roy, Purvi Purohit, Anupama Modi, Manoj Khokhar, Ravindra Kumar Gayaprasad Shukla, Ramkaran Chaudhary, Shrimanjunath Sankanagoudar, Praveen Sharma
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Growth Differentiation Factor 15 Protects SH-SY5Y Cells From Rotenone-Induced Toxicity by Suppressing Mitochondrial Apoptosis
    Peizheng Li, Hongbo Lv, Bohan Zhang, Ruonan Duan, Xiufang Zhang, Pengfei Lin, Chengyuan Song, Yiming Liu
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis
    Lili Yu, Yajing Zhou, Lijuan Wang, Xuan Zhou, Jing Sun, Jiarui Xiao, Xiaolin Xu, Susanna C. Larsson, Shuai Yuan, Xue Li
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Sex-specific modulation of circulating growth differentiation factor-15 in patients with type 2 diabetes and/or obesity
    Mohamed Asrih, Flore Sinturel, Richard Dubos, Idris Guessous, Zoltan Pataky, Charna Dibner, François R Jornayvaz, Karim Gariani
    Endocrine Connections.2022;[Epub]     CrossRef
  • Raised circulating soluble growth differentiation factor 15 is negatively associated with testosterone level in hypogonadic men with type 2 diabetes
    Yufeng Mei, Yongnan Lyu, Juan Le, Di Li, Hang Liu, Zhiming Zhao, Yan Li
    Diabetes/Metabolism Research and Reviews.2022;[Epub]     CrossRef
  • NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice
    Matthew J Jennings, Alexia Kagiava, Leen Vendredy, Emily L Spaulding, Marina Stavrou, Denisa Hathazi, Anika Grüneboom, Vicky De Winter, Burkhard Gess, Ulrike Schara, Oksana Pogoryelova, Hanns Lochmüller, Christoph H Borchers, Andreas Roos, Robert W Burges
    Brain.2022; 145(11): 3999.     CrossRef
  • Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: A hidden treasure
    Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Eman Hassan Nadwa, Sarah M. Albogami, Mohammed Alorabi, Hebatallah M. Saad, Gaber El‐Saber Batiha
    Journal of Diabetes.2022; 14(12): 806.     CrossRef
  • GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans
    Peter Plomgaard, Jakob S. Hansen, Logan K. Townsend, Anders Gudiksen, Niels H. Secher, Jens O. Clemmesen, Rene K. Støving, Jens P. Goetze, David C. Wright, Henriette Pilegaard
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • A study of serum growth differentiation factor 15 in Indian women with and without gestational diabetes mellitus in the third trimester of pregnancy and its association with pro-inflammatory markers and glucose metabolism
    Sudipta Banerjee, Rana Bhattacharjee, Amitabh Sur, Pieu Adhikary, Subhankar Chowdhury
    Diabetology International.2021; 12(3): 254.     CrossRef
  • Growth Differentiation Factor 15 is a Cancer Cell-Induced Mitokine That Primes Thyroid Cancer Cells for Invasiveness
    Yea Eun Kang, Jin Man Kim, Mi Ae Lim, Seong Eun Lee, Shinae Yi, Jung Tae Kim, Chan Oh, Lihua Liu, Yanli Jin, Seung-Nam Jung, Ho-Ryun Won, Jae Won Chang, Jeong Ho Lee, Hyun Jung Kim, Hyun Yong Koh, Sangmi Jun, Sun Wook Cho, Minho Shong, Bon Seok Koo
    Thyroid.2021; 31(5): 772.     CrossRef
  • The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?
    Samuel N. Breit, David A. Brown, Vicky Wang-Wei Tsai
    Annual Review of Physiology.2021; 83(1): 127.     CrossRef
  • Associations of GDF-15 and GDF-15/adiponectin ratio with odds of type 2 diabetes in the Chinese population
    Xiaoying Wu, Wenting Xuan, Lili You, Hong Lian, Feng Li, Xiaoyun Zhang, Qingyu Chen, Kan Sun, Chaogang Chen, Mingtong Xu, Yan Li, Li Yan, Xiuwei Zhang, Meng Ren
    Endocrine.2021; 72(2): 423.     CrossRef
  • Decreased serum growth differentiation factor 15 levels after lifestyle intervention in patients with newly diagnosed type 2 diabetes mellitus
    Xingxing He, Jiaorong Su, Xiaojing Ma, Jingyi Lu, Yufei Wang, Jun Yin, Yuqian Bao, Gang Hu, Jian Zhou
    Obesity Medicine.2021; 24: 100345.     CrossRef
  • The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice
    Pattawika Lertpatipanpong, Jaehak Lee, Ilju Kim, Thomas Eling, Seung Yeon Oh, Je Kyung Seong, Seung Joon Baek
    Scientific Reports.2021;[Epub]     CrossRef
  • The Regulation of Circulating Hepatokines by Fructose Ingestion in Humans
    Michael M Richter, Peter Plomgaard
    Journal of the Endocrine Society.2021;[Epub]     CrossRef
  • GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease
    Dongdong Wang, Emily A. Day, Logan K. Townsend, Djordje Djordjevic, Sebastian Beck Jørgensen, Gregory R. Steinberg
    Nature Reviews Endocrinology.2021; 17(10): 592.     CrossRef
  • High Fat, High Sugar Diet and DJOS Bariatric Surgery Influence Plasma Levels of Fetuin-B, Growth Differentiation Factor-15, and Pentraxin 3 in Diet-Induced Obese Sprague–Dawley Rats
    Jakub Poloczek, Monika Tarnawska, Elżbieta Chełmecka, Piotr Łaszczyca, Janusz Gumprecht, Dominika Stygar
    Nutrients.2021; 13(10): 3632.     CrossRef
  • Serum growth differentiation factor 15 level is associated with muscle strength and lower extremity function in older patients with cardiometabolic disease
    Kazuhito Oba, Joji Ishikawa, Yoshiaki Tamura, Yasunori Fujita, Masafumi Ito, Ai Iizuka, Yoshinori Fujiwara, Remi Kodera, Ayumi Toba, Kenji Toyoshima, Yuko Chiba, Seijiro Mori, Masashi Tanaka, Hideki Ito, Kazumasa Harada, Atsushi Araki
    Geriatrics & Gerontology International.2020; 20(10): 980.     CrossRef
  • Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach
    Axel C. Carlsson, Christoph Nowak, Lars Lind, Carl Johan Östgren, Fredrik H. Nyström, Johan Sundström, Juan Jesus Carrero, Ulf Riserus, Erik Ingelsson, Tove Fall, Johan Ärnlöv
    Upsala Journal of Medical Sciences.2020; 125(1): 37.     CrossRef
  • Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults
    Richard D Semba, Marta Gonzalez-Freire, Toshiko Tanaka, Angelique Biancotto, Pingbo Zhang, Michelle Shardell, Ruin Moaddel, Luigi Ferrucci, Anne Newman
    The Journals of Gerontology: Series A.2020; 75(1): 175.     CrossRef
  • Circulating Cardiac Biomarkers in Diabetes Mellitus: A New Dawn for Risk Stratification—A Narrative Review
    Alexander E. Berezin, Alexander A. Berezin
    Diabetes Therapy.2020; 11(6): 1271.     CrossRef
  • Deterioration of Sleep Quality According to Glycemic Status
    Myung Haeng Hur, Mi-Kyoung Lee, Kayeon Seong, Jun Hwa Hong
    Diabetes & Metabolism Journal.2020; 44(5): 679.     CrossRef
  • Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial
    Mariya Markova, Liselot Koelman, Silke Hornemann, Olga Pivovarova, Stephanie Sucher, Juergen Machann, Natalia Rudovich, Ralph Thomann, Rosemarie Schneeweiss, Sascha Rohn, Andreas F.H. Pfeiffer, Krasimira Aleksandrova
    Clinical Nutrition.2020; 39(3): 862.     CrossRef
  • Effect of sleeve gastrectomy on plasma growth differentiation factor-15 (GDF15) in human
    Ponnie Robertlee Dolo, Libin Yao, Peng Peng Liu, Jason Widjaja, Song Meng, Chao Li, Xiaocheng Zhu
    The American Journal of Surgery.2020; 220(3): 725.     CrossRef
  • Prognostication of clinical outcomes in diabetes mellitus: Emerging role of cardiac biomarkers
    Alexander E. Berezin
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(2): 995.     CrossRef
  • Effect of bariatric surgery on plasma GDF15 in humans
    Maximilian Kleinert, Kirstine N. Bojsen-Møller, Nils B. Jørgensen, Maria S. Svane, Christoffer Martinussen, Bente Kiens, Jørgen F.P. Wojtaszewski, Sten Madsbad, Erik A. Richter, Christoffer Clemmensen
    American Journal of Physiology-Endocrinology and Metabolism.2019; 316(4): E615.     CrossRef
  • Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
    Yea Eun Kang, Hyun Jin Kim, Minho Shong
    Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
  • GDF15 reflects beta cell function in obese patients independently of the grade of impairment of glucose metabolism
    M.H. Schernthaner-Reiter, B.K. Itariu, M. Krebs, M. Promintzer-Schifferl, T.M. Stulnig, A. Tura, C.H. Anderwald, M. Clodi, B. Ludvik, G. Pacini, A. Luger, G. Vila
    Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(4): 334.     CrossRef
  • Growth differentiation factor 15: A novel biomarker with high clinical potential
    Stéphanie Desmedt, Valérie Desmedt, Leen De Vos, Joris R. Delanghe, Reinhart Speeckaert, Marijn M. Speeckaert
    Critical Reviews in Clinical Laboratory Sciences.2019; 56(5): 333.     CrossRef
  • Hepatokines—a novel group of exercise factors
    Cora Weigert, Miriam Hoene, Peter Plomgaard
    Pflügers Archiv - European Journal of Physiology.2019; 471(3): 383.     CrossRef
  • Association between MIC-1 and Type 2 Diabetes: A Combined Analysis
    Jianan Lu, Yue Zhang, Xingxuan Dong, Jiawen Lu, Chen Zhang, Jieyu Liu, Qingzhou Yu, Haoyue Teng, Qingkui Yao, Jieyun Yin, Liqiang Qin
    Disease Markers.2019; 2019: 1.     CrossRef
  • The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
    Hyon-Seung Yi, Joon Young Chang, Minho Shong
    Journal of Molecular Endocrinology.2018; 61(3): R91.     CrossRef
  • Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
    Ana Luisa Cardoso, Adelaide Fernandes, Juan Antonio Aguilar-Pimentel, Martin Hrabě de Angelis, Joana Ribeiro Guedes, Maria Alexandra Brito, Saida Ortolano, Giovambattista Pani, Sophia Athanasopoulou, Efstathios S. Gonos, Markus Schosserer, Johannes Grilla
    Ageing Research Reviews.2018; 47: 214.     CrossRef
  • Serum Meteorin-like protein levels decreased in patients newly diagnosed with type 2 diabetes
    Ju Hee Lee, Yea Eun Kang, Ji Min Kim, Sorim Choung, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
    Diabetes Research and Clinical Practice.2018; 135: 7.     CrossRef
  • Growth differentiation factor 15 predicts advanced fibrosis in biopsy‐proven non‐alcoholic fatty liver disease
    Bo Kyung Koo, Sung Hee Um, Dong Soo Seo, Sae Kyung Joo, Jeong Mo Bae, Jeong Hwan Park, Mee Soo Chang, Jung Ho Kim, Jieun Lee, Won‐Il Jeong, Won Kim
    Liver International.2018; 38(4): 695.     CrossRef
  • Serum Growth Differentiation Factor 15 in Parkinson Disease
    Xiaomei Yao, Dong Wang, Lei Zhang, Lingling Wang, Zhenxiang Zhao, Si Chen, Xiaotang Wang, Tao Yue, Yiming Liu
    Neurodegenerative Diseases.2017; 17(6): 251.     CrossRef
  • GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
    Hyo Kyun Chung, Jung Tae Kim, Hyeon-Woo Kim, Minjoo Kwon, So Yeon Kim, Minho Shong, Koon Soon Kim, Hyon-Seung Yi
    Scientific Reports.2017;[Epub]     CrossRef
  • Growth differentiation factor 15 as a predictor of adverse renal outcomes in patients with immunoglobulin A nephropathy
    Ki R. Na, Yoo H. Kim, Hyo K. Chung, Min‐Kyung Yeo, Young R. Ham, Jin Y. Jeong, Koon S. Kim, Kang W. Lee, Dae E. Choi
    Internal Medicine Journal.2017; 47(12): 1393.     CrossRef
  • GDF15 contributes to radiation-induced senescence through the ROS-mediated p16 pathway in human endothelial cells
    Hyejin Park, Chun-Ho Kim, Jae-Hoon Jeong, Myungjin Park, Kwang Seok Kim
    Oncotarget.2016; 7(9): 9634.     CrossRef
  • GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance
    Mehmet Muhittin Yalcin, Alev Eroglu Altinova, Mujde Akturk, Ozlem Gulbahar, Emre Arslan, Damla Ors Sendogan, Ilhan Yetkin, Fusun Balos Toruner
    Journal of Diabetes Research.2016; 2016: 1.     CrossRef
  • Cardiac‐Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers
    Colleen M. Dewey, Kathryn M. Spitler, Jessica M. Ponce, Duane D. Hall, Chad E. Grueter
    Journal of the American Heart Association.2016;[Epub]     CrossRef
  • Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
    Serdar Farhan, Matthias K. Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber, Alexandra Kautzky-Willer
    Cardiovascular Diabetology.2016;[Epub]     CrossRef
  • Effect of Atorvastatin on Growth Differentiation Factor-15 in Patients with Type 2 Diabetes Mellitus and Dyslipidemia
    Ji Min Kim, Min Kyung Back, Hyon-Seung Yi, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
    Diabetes & Metabolism Journal.2016; 40(1): 70.     CrossRef
  • Association between Growth Differentiation Factor 15 (GDF15) and Cardiovascular Risk in Patients with Newly Diagnosed Type 2 Diabetes Mellitus
    Min Young Shin, Ji Min Kim, Yea Eun Kang, Min Kyeong Kim, Kyong Hye Joung, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong
    Journal of Korean Medical Science.2016; 31(9): 1413.     CrossRef
  • Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose
    Ying Cui, Wen Chen, Jinfeng Chi, Lei Wang
    Medical Science Monitor.2016; 22: 4699.     CrossRef
  • Letter: GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J2014;38:472-9)
    Bo Kyung Koo
    Diabetes & Metabolism Journal.2015; 39(1): 82.     CrossRef
  • Relationship between hepcidin and GDF15 in anemic patients with type 2 diabetes without overt renal impairment
    Jun Hwa Hong, Yeon-Kyung Choi, Byong-Keol Min, Kang Seo Park, Kayeon Seong, In Kyu Lee, Jung Guk Kim
    Diabetes Research and Clinical Practice.2015; 109(1): 64.     CrossRef
  • Response: GDF15 Is a Novel Biomarker for Impaired Fasting Glucose (Diabetes Metab J2014;38:472-9)
    Jun Hwa Hong, Bon Jeong Ku, Minho Shong
    Diabetes & Metabolism Journal.2015; 39(1): 84.     CrossRef
  • Is GDF15 a Novel Biomarker to Predict the Development of Prediabetes or Diabetes?
    Kyu Yeon Hur
    Diabetes & Metabolism Journal.2014; 38(6): 437.     CrossRef
Reviews
Clinical Relevance of Adipokines
Matthias Blüher
Diabetes Metab J. 2012;36(5):317-327.   Published online October 18, 2012
DOI: https://doi.org/10.4093/dmj.2012.36.5.317
  • 4,890 View
  • 65 Download
  • 130 Crossref
AbstractAbstract PDFPubReader   

The incidence of obesity has increased dramatically during recent decades. Obesity increases the risk for metabolic and cardiovascular diseases and may therefore contribute to premature death. With increasing fat mass, secretion of adipose tissue derived bioactive molecules (adipokines) changes towards a pro-inflammatory, diabetogenic and atherogenic pattern. Adipokines are involved in the regulation of appetite and satiety, energy expenditure, activity, endothelial function, hemostasis, blood pressure, insulin sensitivity, energy metabolism in insulin sensitive tissues, adipogenesis, fat distribution and insulin secretion in pancreatic β-cells. Therefore, adipokines are clinically relevant as biomarkers for fat distribution, adipose tissue function, liver fat content, insulin sensitivity, chronic inflammation and have the potential for future pharmacological treatment strategies for obesity and its related diseases. This review focuses on the clinical relevance of selected adipokines as markers or predictors of obesity related diseases and as potential therapeutic tools or targets in metabolic and cardiovascular diseases.

Citations

Citations to this article as recorded by  
  • Adipose tissue inflammation linked to obesity: A review of current understanding, therapies and relevance of phyto-therapeutics
    Christiana Eleojo Aruwa, Saheed Sabiu
    Heliyon.2024; 10(1): e23114.     CrossRef
  • Lower body mass and lower adiposity are associated with differential responses to two treatment strategies for rheumatoid arthritis
    Joshua F Baker, James R ODell, Bryant R England, Jon T Giles, Jefferey A Newcomb, Michael D George, Geoffrey Thiele, Larry Moreland, S Louis Bridges, Jeffrey R Curtis, Ted R Mikuls
    Annals of the Rheumatic Diseases.2024; 83(4): 429.     CrossRef
  • Role of Perturbated Hemostasis in MASLD and Its Correlation with Adipokines
    Salvatore Pezzino, Tonia Luca, Mariacarla Castorina, Stefano Puleo, Saverio Latteri, Sergio Castorina
    Life.2024; 14(1): 93.     CrossRef
  • Associations Between Adiponectin and the Development of Diabetes in Rheumatoid Arthritis
    Joshua F Baker, Bryant R England, Katherine D Wysham, Brian Sauer, Amy M Joseph, Aleksander Lenert, Punyasha Roul, Rui Xiao, Rachel Gillcrist, Tate Johnson, Grant W Cannon, Michael Duryee, Geoffrey M Thiele, Ted R Mikuls
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • Organokinler ve Biyokimyasal Etkileri
    Ahmet İlhan, Umut Kökbaş
    Arşiv Kaynak Tarama Dergisi.2024; 33(1): 71.     CrossRef
  • Clinical Predictive Value and Research Progress of Serum Chemerin
    倩 江
    Advances in Clinical Medicine.2024; 14(04): 2647.     CrossRef
  • NPTX1 Mediates the Facilitating Effects of Hypoxia-Stimulated Human Adipocytes on Adipose-Derived Stem Cell Activation and Autologous Adipose Graft Survival Rate
    Yi Tian, Xiancheng Wang, Yang Sun, Xiang Xiong, Weiliang Zeng, Kai Yang, Hongli Zhao, Yiwen Deng, Dandan Song
    Aesthetic Plastic Surgery.2024;[Epub]     CrossRef
  • Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk
    Jose Marcos Sanches, Li Na Zhao, Albert Salehi, Claes B. Wollheim, Philipp Kaldis
    The FEBS Journal.2023; 290(3): 620.     CrossRef
  • Female infertility in the era of obesity: The clash of two pandemics or inevitable consequence?
    Sanja Medenica, Maria Elena Spoltore, Paulina Ormazabal, Ljiljana V. Marina, Antoan Stefan Sojat, Antongiulio Faggiano, Lucio Gnessi, Rossella Mazzilli, Mikiko Watanabe
    Clinical Endocrinology.2023; 98(2): 141.     CrossRef
  • Relationship Between Obesity with Galanin and Vaspin Levels
    Murat TAKMET, Dilek TÜZÜN, Murat ŞAHİN, Adem DOĞANER, Metin KILINÇ
    Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi.2023; 18(3): 29.     CrossRef
  • Bioprinting: A Strategy to Build Informative Models of Exposure and Disease
    Jose Caceres-Alban, Midori Sanchez, Fanny L. Casado
    IEEE Reviews in Biomedical Engineering.2023; 16: 594.     CrossRef
  • Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review
    Piotr K Krajewski, Łukasz Matusiak, Jacek C Szepietowski
    British Journal of Dermatology.2023; 188(3): 320.     CrossRef
  • Chronic Resistance Training Effects on Serum Adipokines in Type 2 Diabetes Mellitus: A Systematic Review
    Pablo Jiménez-Martínez, Rodrigo Ramirez-Campillo, Carlos Alix-Fages, Javier Gene-Morales, Amador García-Ramos, Juan C. Colado
    Healthcare.2023; 11(4): 594.     CrossRef
  • Vaginal microbiome in obesity and its impact on reproduction
    Akanksha Garg, Laura Burney Ellis, Ryan Laurence Love, Karen Grewal, Sarah Bowden, Phillip R. Bennett, Maria Kyrgiou
    Best Practice & Research Clinical Obstetrics & Gynaecology.2023; 90: 102365.     CrossRef
  • Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain
    Dillon Mintoff, Rachel Agius, Farida Benhadou, Anupam Das, John W Frew, Nikolai P Pace
    Clinical and Experimental Dermatology.2023; 48(9): 984.     CrossRef
  • Autoimmune diseases and risk of gestational diabetes mellitus: a Mendelian randomization study
    Xia Zhang, Xiuyan Wu, Lihong Chen, Lidan He
    Acta Diabetologica.2023; 61(2): 161.     CrossRef
  • Omentin roles in physiology and pathophysiology: an up-to-date comprehensive review
    Aida A. Hussein, Noha A. Ahmed, Hader I. Sakr, Tarek Atia, Osama M. Ahmed
    Archives of Physiology and Biochemistry.2023; : 1.     CrossRef
  • Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus
    Maciej Kamiński, Radzisław Mierzyński, Elżbieta Poniedziałek-Czajkowska, Agata Sadowska, Maciej Sotowski, Bożena Leszczyńska-Gorzelak
    International Journal of Molecular Sciences.2023; 25(1): 175.     CrossRef
  • The Implications of Bone Marrow Adipose Tissue on Inflammaging
    Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Drug-induced metabolic alterations in adipose tissue - with an emphasis in epicardial adipose tissue
    ARYANE C.O. PINHO, ANA BURGEIRO, MARIA JOÃO PEREIRA, EUGENIA CARVALHO
    Anais da Academia Brasileira de Ciências.2022;[Epub]     CrossRef
  • Low Risk for Developing Diabetes Among the Offspring of Individuals With Exceptional Longevity and Their Spouses
    Iva Miljkovic, Ryan Cvejkus, Ping An, Bharat Thyagarajan, Kaare Christensen, Mary Wojczynski, Nicole Schupf, Joseph M. Zmuda
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene
    Karen C. Clark, Valerie A. Wagner, Katie L. Holl, John J. Reho, Monika Tutaj, Jennifer R. Smith, Melinda R. Dwinell, Justin L. Grobe, Anne E. Kwitek
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Leptin treatment has vasculo-protective effects in lipodystrophic mice
    Paulina Elena Stürzebecher, Susan Kralisch, Marie Ruth Schubert, Vanina Filipova, Annett Hoffmann, Fabiana Oliveira, Bilal N. Sheikh, Matthias Blüher, Alexander Kogel, Markus Scholz, Karoline Elizabeth Kokot, Stephan Erbe, Jasmin Marga Kneuer, Thomas Eber
    Proceedings of the National Academy of Sciences.2022;[Epub]     CrossRef
  • Adipokines as potential biomarkers for type 2 diabetes mellitus in cats
    Olga Sierawska, Paulina Niedźwiedzka-Rystwej
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
    Pamela A. Nono Nankam, Manuel Cornely, Nora Klöting, Matthias Blüher
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Tea Plant (Camellia sinensis): A Current Update on Use in Diabetes, Obesity, and Cardiovascular Disease
    James Michael Brimson, Mani Iyer Prasanth, Kishoree Krishna Kumaree, Premrutai Thitilertdecha, Dicson Sheeja Malar, Tewin Tencomnao, Anchalee Prasansuklab
    Nutrients.2022; 15(1): 37.     CrossRef
  • Leptin and Adiponectin Concentrations Independently Predict Future Accumulation of Visceral Fat in Nondiabetic Japanese Americans
    Sun Ok Song, Seung Jin Han, Steven E. Kahn, Donna L. Leonetti, Wilfred Y. Fujimoto, Edward J. Boyko
    Obesity.2021; 29(1): 233.     CrossRef
  • Endothelial Cell–Derived Triosephosphate Isomerase Attenuates Insulin Secretion From Pancreatic Beta Cells of Male Rats
    Bareket Daniel, Ariela Livne, Guy Cohen, Shirin Kahremany, Shlomo Sasson
    Endocrinology.2021;[Epub]     CrossRef
  • Visfatin level and gestational diabetes mellitus: a systematic review and meta-analysis
    Yong-Kuan Jiang, Hai-Yan Deng, Zeng-Yong Qiao, Fang-Xiao Gong
    Archives of Physiology and Biochemistry.2021; 127(5): 468.     CrossRef
  • Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer
    Yetirajam Rajesh, Devanand Sarkar
    International Journal of Molecular Sciences.2021; 22(4): 2163.     CrossRef
  • Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry
    Pamela A. Nono Nankam, Télesphore B. Nguelefack, Julia H. Goedecke, Matthias Blüher
    Antioxidants.2021; 10(4): 622.     CrossRef
  • Retinol-binding protein 4 in obesity and metabolic dysfunctions
    Pamela A. Nono Nankam, Matthias Blüher
    Molecular and Cellular Endocrinology.2021; 531: 111312.     CrossRef
  • The Potential Role of Chemerin, Lipocalin 2, and Apelin in the Diagnosis and Pathophysiology of Gestational Diabetes Mellitus
    Radzisław Mierzyński, Elżbieta Poniedziałek-Czajkowska, Dominik Dłuski, Maciej Kamiński, Agnieszka Mierzyńska, Bożena Leszczyńska-Gorzelak, Antonio Schiattarella
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
  • A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity
    Mahmood Safaei, Elankovan A. Sundararajan, Maha Driss, Wadii Boulila, Azrulhizam Shapi'i
    Computers in Biology and Medicine.2021; 136: 104754.     CrossRef
  • Does a Vegetarian Diet Affect the Levels of Myokine and Adipokine in Prepubertal Children?
    Jadwiga Ambroszkiewicz, Joanna Gajewska, Joanna Mazur, Witold Klemarczyk, Grażyna Rowicka, Mariusz Ołtarzewski, Małgorzata Strucińska, Magdalena Chełchowska
    Journal of Clinical Medicine.2021; 10(17): 3995.     CrossRef
  • Characteristics of Selected Adipokines in Ascites and Blood of Ovarian Cancer Patients
    Marcin Wróblewski, Karolina Szewczyk-Golec, Iga Hołyńska-Iwan, Joanna Wróblewska, Alina Woźniak
    Cancers.2021; 13(18): 4702.     CrossRef
  • Nutrition as Prevention Factor of Gestational Diabetes Mellitus: A Narrative Review
    Radzisław Mierzyński, Elżbieta Poniedziałek-Czajkowska, Maciej Sotowski, Magdalena Szydełko-Gorzkowicz
    Nutrients.2021; 13(11): 3787.     CrossRef
  • The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
    Jung Ok Lee, Won Seok Byun, Min Ju Kang, Jeong Ah Han, Jiyoung Moon, Min‐Jeong Shin, Ho Jun Lee, Ji Hyung Chung, Jin‐Seok Lee, Chang‐Gue Son, Kwon‐Ho Song, Tae Woo Kim, Eun‐Soo Lee, Hong Min Kim, Choon Hee Chung, Kevin R. W. Ngoei, Naomi X. Y. Ling, Jonat
    The FEBS Journal.2020; 287(10): 2087.     CrossRef
  • Plasma Adipsin as a Biomarker and Its Implication in Type 2 Diabetes Mellitus


    Gebrehiwot Gebremedhin Tafere, Dawit Zewdu Wondafrash, Kaleab Alemayehu Zewdie, Brhane Teklebrhan Assefa, Muluken Altaye Ayza
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 1855.     CrossRef
  • Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia
    Abhinav Choubey, Khyati Girdhar, Aditya K. Kar, Shaivya Kushwaha, Manoj Kumar Yadav, Debabrata Ghosh, Prosenjit Mondal
    Journal of Biological Chemistry.2020; 295(48): 16359.     CrossRef
  • Association between Adipokines and Biomarkers of Alzheimer’s Disease: A Cross-Sectional Study
    Liliana Letra, Paulo Matafome, Tiago Rodrigues, Diana Duro, Raquel Lemos, Inês Baldeiras, Miguel Patrício, Miguel Castelo-Branco, Gina Caetano, Raquel Seiça, Isabel Santana
    Journal of Alzheimer's Disease.2019; 67(2): 725.     CrossRef
  • Role of adiponectin and its target receptors to control deposition of fat in obesity related disorders
    souravh Bais, Nilesh J. Patel
    Obesity Medicine.2019; 16: 100148.     CrossRef
  • Circulatory Omentin-1 levels but not genetic variants influence the pathophysiology of Type 2 diabetes
    Nirali Rathwa, Roma Patel, Sayantani Pramanik Palit, Shahnawaz D. Jadeja, Mahendra Narwaria, A.V. Ramachandran, Rasheedunnisa Begum
    Cytokine.2019; 119: 144.     CrossRef
  • Roles of omental and bone marrow adipocytes in tumor biology
    Yoon Jin Cha, Ja Seung Koo
    Adipocyte.2019; 8(1): 304.     CrossRef
  • Genetic susceptibility of Iraqis for obesity and type 2 diabetes: LEPR gene polymorphisms
    Maysoon K. Almyah, Adnan Issa Al-Badran
    Gene Reports.2019; 15: 100386.     CrossRef
  • New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
    Marta Olivera-Santa Catalina, Pedro C. Redondo, Maria P. Granados, Carlos Cantonero, Jose Sanchez-Collado, Letizia Albarran, Jose J. Lopez
    Current Medicinal Chemistry.2019; 26(22): 4119.     CrossRef
  • Impact of Intragastric Balloon Treatment on Adipokines, Cytokines, and Metabolic Profile in Obese Individuals
    Marcella Rodrigues Guedes, Ricardo José Fittipaldi-Fernandez, Cristina Fajardo Diestel, Márcia Regina Simas Torres Klein
    Obesity Surgery.2019; 29(8): 2600.     CrossRef
  • The cross-talk between adipokines and miRNAs in health and obesity-mediated diseases
    Ahmad Ghasemi, Seyed Isaac Hashemy, Mohsen Azimi-Nezhad, Alireza Dehghani, Jafar Saeidi, Mahnaz Mohtashami
    Clinica Chimica Acta.2019; 499: 41.     CrossRef
  • Minor lipids profiling in subcutaneous and epicardial fat tissue using LC/MS with an optimized preanalytical phase
    Petra Tomášová, Martina Čermáková, Helena Pelantová, Marek Vecka, Helena Kratochvílová, Michal Lipš, Jaroslav Lindner, Blanka Šedivá, Martin Haluzík, Marek Kuzma
    Journal of Chromatography B.2019; 1113: 50.     CrossRef
  • Impact of body weight gain on hepatic metabolism and hepatic inflammatory cytokines in comparison of Shetland pony geldings and Warmblood horse geldings
    Carola Schedlbauer, Dominique Blaue, Martin Gericke, Matthias Blüher, Janine Starzonek, Claudia Gittel, Walter Brehm, Ingrid Vervuert
    PeerJ.2019; 7: e7069.     CrossRef
  • Lipid classes in adipose tissues and liver differ between Shetland ponies and Warmblood horses
    Stephanie Adolph, Carola Schedlbauer, Dominique Blaue, Axel Schöniger, Claudia Gittel, Walter Brehm, Herbert Fuhrmann, Ingrid Vervuert, Juan J. Loor
    PLOS ONE.2019; 14(3): e0207568.     CrossRef
  • Effects of Probiotic Yogurt on Serum Omentin-1, Adropin, and Nesfatin-1 Concentrations in Overweight and Obese Participants Under Low-Calorie Diet
    Mitra Zarrati, Mahsa Raji Lahiji, Eisa Salehi, Bahareh Yazdani, Elham Razmpoosh, Raheleh Shokouhi Shoormasti, Farzad Shidfar
    Probiotics and Antimicrobial Proteins.2019; 11(4): 1202.     CrossRef
  • Placental expressions and serum levels of adiponectin, visfatin, and omentin in GDM
    Xaynaly Souvannavong-Vilivong, Chantacha Sitticharoon, Roongrit Klinjampa, Issarawan Keadkraichaiwat, Chanakarn Sripong, Saimai Chatree, Rungnapa Sririwichitchai, Tripop Lertbunnaphong
    Acta Diabetologica.2019; 56(10): 1121.     CrossRef
  • Angiotensin-(1-7), Adipokines and Inflammation
    Deborah de Farias Lelis, Daniela Fernanda de Freitas, Amanda Souto Machado, Thaísa Soares Crespo, Sérgio Henrique Sousa Santos
    Metabolism.2019; 95: 36.     CrossRef
  • Recent advances in biosensor technology in assessment of early diabetes biomarkers
    Armin Salek-Maghsoudi, Faezeh Vakhshiteh, Raheleh Torabi, Shokoufeh Hassani, Mohammad Reza Ganjali, Parviz Norouzi, Morteza Hosseini, Mohammad Abdollahi
    Biosensors and Bioelectronics.2018; 99: 122.     CrossRef
  • Potential role of microRNAs in the regulation of adipocytes liposecretion and adipose tissue physiology
    Giulia Maurizi, Lucia Babini, Lucio Della Guardia
    Journal of Cellular Physiology.2018; 233(12): 9077.     CrossRef
  • Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes
    Hyekyung Yang, Dong Ho Suh, Dae Hee Kim, Eun Sung Jung, Kwang‐Hyeon Liu, Choong Hwan Lee, Cheol‐Young Park
    British Journal of Pharmacology.2018; 175(17): 3610.     CrossRef
  • Implications of circulating Meteorin-like (Metrnl) level in human subjects with type 2 diabetes
    Hye Soo Chung, Soon Young Hwang, Ju Hee Choi, Hyun Jung Lee, Nam Hoon Kim, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
    Diabetes Research and Clinical Practice.2018; 136: 100.     CrossRef
  • Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets
    Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Grażyna Rowicka, Witold Klemarczyk, Małgorzata Strucińska, Joanna Gajewska
    Nutrients.2018; 10(9): 1241.     CrossRef
  • Adipokine profile as a novel screening method for cardiometabolic disease: Help or hindrance?
    Ivana Veljić, Marija Polovina, Jelena P Seferović, Petar M Seferović
    European Journal of Preventive Cardiology.2018; 25(14): 1543.     CrossRef
  • Adipocytes and intestinal epithelium dysfunctions linking obesity to inflammation induced by high glycemic index pellet-diet in Wistar rats
    Anna Beatriz Santana Luz, Júlia Braga dos Santos Figueredo, Bianca Damásio Pereira Dantas Salviano, Ana Júlia Felipe Camelo Aguiar, Luiza Gabriella Soares Dantas Pinheiro, Matheus Felipe Dantas Krause, Christina da Silva Camillo, Fernando Vagner Lobo Ladd
    Bioscience Reports.2018;[Epub]     CrossRef
  • The effect of diet, adiposity, and weight loss on the secretion of incretin hormones in cats
    K.E. McCool, A.J. Rudinsky, V.J. Parker, C.O. Herbert, C. Gilor
    Domestic Animal Endocrinology.2018; 62: 67.     CrossRef
  • Carnosine Supplementation Improves Serum Resistin Concentrations in Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
    Estifanos Baye, Jozef Ukropec, Maximilian P. J. De Courten, Aya Mousa, Timea Kurdiova, Josphin Johnson, Kirsty Wilson, Magdalena Plebanski, Giancarlo Aldini, Barbara Ukropcova, Barbora De Courten
    Nutrients.2018; 10(9): 1258.     CrossRef
  • Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells
    Sabena M. Conley, Xiang-Yang Zhu, Alfonso Eirin, Hui Tang, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
    Gene.2018; 644: 101.     CrossRef
  • Changes in Omentin Levels and Its mRNA Expression in Epicardial Adipose Tissue in Patients Undergoing Elective Cardiac Surgery: the Influence of Type 2 Diabetes and Coronary Heart Disease
    Z. MATLOCH, H. KRATOCHVÍLOVÁ, A. CINKAJZLOVÁ, M. LIPŠ, P. KOPECKÝ, M. POŘÍZKA, D. HALUZÍKOVÁ, J. LINDNER, M. MRÁZ, J. KLOUČKOVÁ, Z. LACINOVÁ, M. HALUZÍK
    Physiological Research.2018; : 881.     CrossRef
  • Apport du tissu adipeux et de la fraction vasculaire stromale en chirurgie de la main
    I. Nseir, F. Delaunay, C. Latrobe, A. Bonmarchand, D. Coquerel-Beghin, I. Auquit-Auckbur
    Revue de Chirurgie Orthopédique et Traumatologique.2017; 103(6): 643.     CrossRef
  • Specific Strains of Lactic Acid Bacteria Differentially Modulate the Profile of Adipokines In Vitro
    Emanuel Fabersani, María Claudia Abeijon-Mukdsi, Romina Ross, Roxana Medina, Silvia González, Paola Gauffin-Cano
    Frontiers in Immunology.2017;[Epub]     CrossRef
  • Use of adipose tissue and stromal vascular fraction in hand surgery
    I. Nseir, F. Delaunay, C. Latrobe, A. Bonmarchand, D. Coquerel-Beghin, I. Auquit-Auckbur
    Orthopaedics & Traumatology: Surgery & Research.2017; 103(6): 927.     CrossRef
  • Investigating the role of adipokines in chronic migraine
    Elisa Rubino, Alessandro Vacca, Flora Govone, Annalisa Gai, Silvia Boschi, Milena Zucca, Paola De Martino, Salvatore Gentile, Lorenzo Pinessi, Innocenzo Rainero
    Cephalalgia.2017; 37(11): 1067.     CrossRef
  • Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears
    K. S. Rigano, J. L. Gehring, B. D. Evans Hutzenbiler, A. V. Chen, O. L. Nelson, C. A. Vella, C. T. Robbins, H. T. Jansen
    Journal of Comparative Physiology B.2017; 187(4): 649.     CrossRef
  • Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study
    Christoph Bickel, Renate B. Schnabel, Tanja Zeller, Karl J. Lackner, Hans J. Rupprecht, Stefan Blankenberg, Christoph Sinning, Dirk Westermann
    Biomarkers.2017; 22(3-4): 210.     CrossRef
  • Omentin-A Novel Adipokine in Respiratory Diseases
    Yan Zhou, Bo Zhang, Caixia Hao, Xiaoting Huang, Xiaohong Li, Yanhong Huang, Ziqiang Luo
    International Journal of Molecular Sciences.2017; 19(1): 73.     CrossRef
  • Exercise training lowers serum chemerin concentration in obese children
    F. Zehsaz, N. Farhangi, M. Ghahramani
    Science & Sports.2017; 32(1): 39.     CrossRef
  • MicroRNAs and adipocytokines: Promising biomarkers for pharmacological targets in diabetes mellitus and its complications
    Mohamad Reza Ashoori, Mohammad Rahmati-Yamchi, Alireza Ostadrahimi, Sedigheh Fekri Aval, Nosratollah Zarghami
    Biomedicine & Pharmacotherapy.2017; 93: 1326.     CrossRef
  • Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir
    Paweł Olczyk, Robert Koprowski, Katarzyna Komosinska-Vassev, Agnieszka Jura-Półtorak, Katarzyna Winsz-Szczotka, Kornelia Kuźnik-Trocha, Łukasz Mencner, Alicja Telega, Diana Ivanova, Krystyna Olczyk
    Molecules.2017; 22(8): 1274.     CrossRef
  • C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells
    Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Sang-Wook Kang, Woo Je Lee, Joong-Yeol Park
    Molecular and Cellular Endocrinology.2016; 419: 235.     CrossRef
  • Effects of high glucose on caveolin-1 and insulin signaling in 3T3-L1 adipocytes
    Sara Palacios-Ortega, Maider Varela-Guruceaga, J. Alfredo Martínez, Carlos de Miguel, Fermín I. Milagro
    Adipocyte.2016; 5(1): 65.     CrossRef
  • The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis
    Kyung Mook Choi
    Endocrinology and Metabolism.2016; 31(1): 1.     CrossRef
  • Molecular Pathogenesis of NASH
    Alessandra Caligiuri, Alessandra Gentilini, Fabio Marra
    International Journal of Molecular Sciences.2016; 17(9): 1575.     CrossRef
  • Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines
    Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger, Annette Peters
    Diabetes.2016; 65(11): 3314.     CrossRef
  • Anti-inflammatory effects of sucrose-derived oligosaccharides produced by a constitutive mutant L. mesenteroides B-512FMCM dextransucrase in high fat diet-fed mice
    Min-Gyung Kang, Hee Jae Lee, Jae-Young Cho, Kanghwa Kim, Soo Jin Yang, Doman Kim
    Biochemical and Biophysical Research Communications.2016; 477(3): 350.     CrossRef
  • UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin
    Eun Ju Kim, Yeon Kyung Kim, Min-Kyoung Kim, Sungsoo Kim, Jin Yong Kim, Dong Hun Lee, Jin Ho Chung
    Scientific Reports.2016;[Epub]     CrossRef
  • Adipokines in health and disease
    Mathias Fasshauer, Matthias Blüher
    Trends in Pharmacological Sciences.2015; 36(7): 461.     CrossRef
  • Les cellules stromales mésenchymateuses du tissu adipeux : historique, isolement, propriétés immunomodulatrices et perspectives cliniques
    N. Bertheuil, B. Chaput, C. Ménard, A. Varin, I. Garrido, J.L. Grolleau, L. Sensébé, E. Watier, K. Tarte
    Annales de Chirurgie Plastique Esthétique.2015; 60(2): 94.     CrossRef
  • Oncostatin M Modulation of Lipid Storage
    Carrie Elks, Jacqueline Stephens
    Biology.2015; 4(1): 151.     CrossRef
  • Adiposité, hypoxie et apnées du sommeil : de l’obésité au syndrome métabolique
    P. Böhme, P. Corbonnois, L. Duchesne, D. Quilliot, O. Ziegler
    Obésité.2015; 10(3): 204.     CrossRef
  • ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction
    Raquel de Oliveira, Tamiris Invencioni Moraes, Alvaro Cerda, Mario Hiroyuki Hirata, Cristina Moreno Fajardo, Marcela Correia Sousa, Egidio Lima Dorea, Márcia Martins Silveira Bernik, Rosario Dominguez Crespo Hirata
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
    Adil Mardinoglu, John T. Heiker, Daniel Gärtner, Elias Björnson, Michael R. Schön, Gesine Flehmig, Nora Klöting, Knut Krohn, Mathias Fasshauer, Michael Stumvoll, Jens Nielsen, Matthias Blüher
    Scientific Reports.2015;[Epub]     CrossRef
  • Involvement of resveratrol in crosstalk between adipokine adiponectin and hepatokine fetuin-A in vivo and in vitro
    Hee Jae Lee, Yunsook Lim, Soo Jin Yang
    The Journal of Nutritional Biochemistry.2015; 26(11): 1254.     CrossRef
  • Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes
    Hee Jae Lee, Young-Shick Hong, Woojin Jun, Soo Jin Yang
    Journal of Medicinal Food.2015; 18(11): 1207.     CrossRef
  • Inverse Relationship between Serum Lipoxin A4 Level and the Risk of Metabolic Syndrome in a Middle-Aged Chinese Population
    Dan Yu, Zhiye Xu, Xueyao Yin, Fenping Zheng, Xihua Lin, Qianqian Pan, Hong Li, Liqing Yu
    PLOS ONE.2015; 10(11): e0142848.     CrossRef
  • Autophagy in adipose tissue of patients with obesity and type 2 diabetes
    J. Kosacka, M. Kern, N. Klöting, S. Paeschke, A. Rudich, Y. Haim, M. Gericke, H. Serke, M. Stumvoll, I. Bechmann, M. Nowicki, M. Blüher
    Molecular and Cellular Endocrinology.2015; 409: 21.     CrossRef
  • Autocrine/Paracrine Function of Globular Adiponectin: Inhibition of Lipid Metabolism and Inflammatory Response in 3T3-L1 Adipocytes
    Yulia Lazra, Alona Falach, Lital Frenkel, Konstantin Rozenberg, Sanford Sampson, Tovit Rosenzweig
    Journal of Cellular Biochemistry.2015; 116(5): 754.     CrossRef
  • From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century
    Matthias Blüher, Christos S. Mantzoros
    Metabolism.2015; 64(1): 131.     CrossRef
  • Serum adiponectin levels in patients with acute coronary syndromes: Serial changes and relation to infarct size
    Hadeel Alkofide, Gordon S Huggins, Robin Ruthazer, Joni R Beshansky, Harry P Selker
    Diabetes and Vascular Disease Research.2015; 12(6): 411.     CrossRef
  • Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity
    Silvia Barja-Fernández, Cintia Folgueira, Cecilia Castelao, Rosaura Leis, Felipe F. Casanueva, Luisa M. Seoane
    Gastroenterology Research and Practice.2015; 2015: 1.     CrossRef
  • Association of serum omentin-1 concentrations with the presence and severity of preeclampsia
    Haiping Liu, Jianfeng Wu, Haiyu Wang, Lianbing Sheng, Ning Tang, Yunfei Li, Tianyu Hao
    Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.2015; 52(2): 245.     CrossRef
  • Asthma and metabolic syndrome: Current knowledge and future perspectives
    Laura Serafino-Agrusa
    World Journal of Clinical Cases.2015; 3(3): 285.     CrossRef
  • CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators
    Arturo Roca-Rivada, Susana Belen Bravo, Diego Pérez-Sotelo, Jana Alonso, Ana Isabel Castro, Iván Baamonde, Javier Baltar, Felipe F. Casanueva, María Pardo
    Scientific Reports.2015;[Epub]     CrossRef
  • Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte‐mediated growth inhibition of anagen‐phase vibrissa hair
    Chao‐Chun Yang, Hamm‐Ming Sheu, Pei‐Lun Chung, Chung‐Hsing Chang, Yau‐Sheng Tsai, Michael W. Hughes, Tai‐Lan Tuan, Lynn L. H. Huang
    Experimental Dermatology.2015; 24(1): 57.     CrossRef
  • Association of serum C1q/TNF-Related Protein-9 (CTRP9) concentration with visceral adiposity and metabolic syndrome in humans
    Y-C Hwang, S Woo Oh, S-W Park, C-Y Park
    International Journal of Obesity.2014; 38(9): 1207.     CrossRef
  • Adipocyte dysfunction, inflammation and metabolic syndrome
    Nora Klöting, Matthias Blüher
    Reviews in Endocrine and Metabolic Disorders.2014; 15(4): 277.     CrossRef
  • Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris
    Kyung Mook Choi, Soon Young Hwang, Ho Chel Hong, Hae Yoon Choi, Hye Jin Yoo, Byung-Soo Youn, Sei Hyun Baik, Hong Seog Seo
    Cardiovascular Diabetology.2014;[Epub]     CrossRef
  • Serum Concentrations and Subcutaneous Adipose Tissue mRNA Expression of Omentin in Morbid Obesity and Type 2 Diabetes Mellitus: the Effect of Very-Low-Calorie Diet, Physical Activity and Laparoscopic Sleeve Gastrectomy
    M. URBANOVÁ, I. DOSTÁLOVÁ, P. TRACHTA, J. DRÁPALOVÁ, P. KAVÁLKOVÁ, D. HALUZÍKOVÁ, M. MATOULEK, Z. LACINOVÁ, M. MRÁZ, M. KASALICKÝ, M. HALUZÍK
    Physiological Research.2014; : 207.     CrossRef
  • Impact of Visceral Fat on Skeletal Muscle Mass and Vice Versa in a Prospective Cohort Study: The Korean Sarcopenic Obesity Study (KSOS)
    Tae Nyun Kim, Man Sik Park, Ja Young Ryu, Hae Yoon Choi, Ho Cheol Hong, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Seok Won Park, Sei Hyun Baik, Anne B. Newman, Kyung Mook Choi, Rozalyn M. Anderson
    PLoS ONE.2014; 9(12): e115407.     CrossRef
  • Links Between Ectopic Fat and Vascular Disease in Humans
    Soo Lim, James B. Meigs
    Arteriosclerosis, Thrombosis, and Vascular Biology.2014; 34(9): 1820.     CrossRef
  • Circulating levels of adipokines in Parkinson's disease
    Natália Pessoa Rocha, Paula Luciana Scalzo, Izabela Guimarães Barbosa, Mariana Soares de Sousa, Isabela Boechat Morato, Érica Leandro Marciano Vieira, Paulo Pereira Christo, Helton José Reis, Antônio Lúcio Teixeira
    Journal of the Neurological Sciences.2014; 339(1-2): 64.     CrossRef
  • Das Fettgewebe – ein endokrines Organ
    M. Blüher
    Der Internist.2014; 55(6): 687.     CrossRef
  • The prediction role of indexes of circulating adipokines for common anthropometric and nutritional characteristics of obesity in the obese Central European population
    Julie Bienertová-Vašků, Jan Novák, Filip Zlámal, Martin Forejt, Soňa Havlenová, Aneta Jackowská, Josef Tomandl, Marie Tomandlová, Zbyněk Šplíchal, Anna Vašků
    Eating Behaviors.2014; 15(2): 244.     CrossRef
  • Das Fettgewebe – ein endokrines Organ
    M. Blüher
    Humanmedizin kompakt.2014;[Epub]     CrossRef
  • An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: Possible implications for cancer research
    Faina Linkov, Lora E. Burke, Marina Komaroff, Robert P. Edwards, Anna Lokshin, Mindi A. Styn, Eugene Tseytlin, Kyle E. Freese, Dana H. Bovbjerg
    Gynecologic Oncology.2014; 133(1): 67.     CrossRef
  • Adipose tissue and its role in organ crosstalk
    T. Romacho, M. Elsen, D. Röhrborn, J. Eckel
    Acta Physiologica.2014; 210(4): 733.     CrossRef
  • Adipokines – removing road blocks to obesity and diabetes therapy
    Matthias Blüher
    Molecular Metabolism.2014; 3(3): 230.     CrossRef
  • Relationship Between Retinol-Binding Protein-4/Adiponectin and Leptin/Adiponectin Ratios with Insulin Resistance and Inflammation
    Ishwarlal Jialal, Beverley Adams-Huet, Frank Duong, Gerred Smith
    Metabolic Syndrome and Related Disorders.2014; 12(4): 227.     CrossRef
  • Metabolically Healthy Obesity—Does it Exist?
    Patchaya Boonchaya-anant, Caroline M. Apovian
    Current Atherosclerosis Reports.2014;[Epub]     CrossRef
  • Strong correlations between circulating chemerin levels and lipoprotein subfractions in nondiabetic obese and nonobese subjects
    Hajnalka Lőrincz, Mónika Katkó, Mariann Harangi, Sándor Somodi, Krisztina Gaál, Péter Fülöp, György Paragh, Ildikó Seres
    Clinical Endocrinology.2014; 81(3): 370.     CrossRef
  • Physical inactivity, insulin resistance, and the oxidative-inflammatory loop
    A. Gratas-Delamarche, F. Derbré, S. Vincent, J. Cillard
    Free Radical Research.2014; 48(1): 93.     CrossRef
  • Oncostatin M Is Produced in Adipose Tissue and Is Regulated in Conditions of Obesity and Type 2 Diabetes
    David Sanchez-Infantes, Ursula A. White, Carrie M. Elks, Ron F. Morrison, Jeffrey M. Gimble, Robert V. Considine, Anthony W. Ferrante, Eric Ravussin, Jacqueline M. Stephens
    The Journal of Clinical Endocrinology & Metabolism.2014; 99(2): E217.     CrossRef
  • Bright light enhances the efficiency of physical activity in combination with a restrictive diet
    Boris B. Pinkhasov, Vera G. Selyatitskaya, Ani R. Karapetyan
    Health.2014; 06(03): 202.     CrossRef
  • Impact of obesity on cardiovascular health
    Marzena Chrostowska, Anna Szyndler, Michał Hoffmann, Krzysztof Narkiewicz
    Best Practice & Research Clinical Endocrinology & Metabolism.2013; 27(2): 147.     CrossRef
  • The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations
    Darlene E. Berryman, Camilla A. M. Glad, Edward O. List, Gudmundur Johannsson
    Nature Reviews Endocrinology.2013; 9(6): 346.     CrossRef
  • Phosphodiesterase 5 as target for adipose tissue disorders
    Giovani Colombo, Maria Daniela H. Périco Colombo, Leonardo De Lucca Schiavon, Armando José d’Acampora
    Nitric Oxide.2013; 35: 186.     CrossRef
  • Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms
    Barbara Strasser, Dominik Pesta
    BioMed Research International.2013; 2013: 1.     CrossRef
  • Adipose tissue dysfunction contributes to obesity related metabolic diseases
    Matthias Blüher
    Best Practice & Research Clinical Endocrinology & Metabolism.2013; 27(2): 163.     CrossRef
  • Importance of adipokines in glucose homeostasis
    Matthias Blüher
    Diabetes Management.2013; 3(5): 389.     CrossRef
  • Association of Glypican-4 With Body Fat Distribution, Insulin Resistance, and Nonalcoholic Fatty Liver Disease
    H. J. Yoo, S. Y. Hwang, G. J. Cho, H. C. Hong, H. Y. Choi, T. G. Hwang, S. M. Kim, Matthias Blüher, Byung-Soo Youn, S. H. Baik, K. M. Choi
    The Journal of Clinical Endocrinology & Metabolism.2013; 98(7): 2897.     CrossRef
  • Association of Serum Adiponectin, Leptin, and Resistin Concentrations with the Severity of Liver Dysfunction and the Disease Complications in Alcoholic Liver Disease
    Beata Kasztelan-Szczerbinska, Agata Surdacka, Maria Slomka, Jacek Rolinski, Krzysztof Celinski, Agata Smolen, Mariusz Szczerbinski
    Mediators of Inflammation.2013; 2013: 1.     CrossRef
  • RLIP76 Protein Knockdown Attenuates Obesity Due to a High-fat Diet
    Sharad S. Singhal, James Figarola, Jyotsana Singhal, Marpadga A. Reddy, Xueli Liu, David Berz, Rama Natarajan, Sanjay Awasthi
    Journal of Biological Chemistry.2013; 288(32): 23394.     CrossRef
  • Tumor Necrosis Factor-α as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study
    Yun Yong Seo, Yong Kyun Cho, Ji-Cheol Bae, Mi Hae Seo, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    Endocrinology and Metabolism.2013; 28(1): 41.     CrossRef
  • Adipose Tissue Dysfunction in Nascent Metabolic Syndrome
    Andrew A. Bremer, Ishwarlal Jialal
    Journal of Obesity.2013; 2013: 1.     CrossRef
Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications.
Jang Won Son, Hyuk Sang Kwon
Korean Diabetes J. 2009;33(5):363-372.   Published online October 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.5.363
  • 2,115 View
  • 19 Download
AbstractAbstract PDF
Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.
Non-invasive Methods for Cardiovascular Risk Assessment in Asymptomatic Type 2 Diabetes Mellitus.
Jee In Lee, Hyun Shik Son
Korean Diabetes J. 2009;33(4):267-275.   Published online August 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.4.267
  • 2,398 View
  • 20 Download
  • 1 Crossref
AbstractAbstract PDF
Cardiovascular disease (CVD) is the major cause of mortality in type 2 diabetes mellitus. CVD is a clinical manifestation of atherosclerosis, a chronic and progressive inflammatory disease characterized by a long asymptomatic phase. Progression of atherosclerosis can lead to the occurrence of acute cardiovascular events. Atherosclerosis can be identified during the subclinical phase by several methods, including using biomarkers, pulse wave velocity, augmentation index, flow-mediated dilation, carotid ultrasound, and calcium score. The appropriate criteria for identifying asymptomatic patients with type 2 diabetes who should undergo CVD screening and therapeutic intervention remain controversial. Non-invasive methods, such as markers of subclinical atherosclerosis, may aid in risk stratification and the design of tailored therapies for patients with type 2 diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Outpatient Testing for Diabetic Complications
    Dong-Hyeok Cho
    The Journal of Korean Diabetes.2016; 17(4): 246.     CrossRef
Double Diabetes.
Sang Youl Rhee, Young Seol Kim
Korean Diabetes J. 2009;33(1):1-8.   Published online February 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.1.1
  • 2,078 View
  • 26 Download
AbstractAbstract PDF
Generally, most cases of diabetes mellitus (DM) are classified as either type 1 DM or type 2 DM based on their pathophysiolgic features. However, it is not always possible to classify this disease clearly according to current diagnostic criteria. Recently, the existence of non-typical diabetes has been found in patients with simultaneous features of both type 1 and type 2 DM. In these patients, obvious evidence of insulin resistance, positivity of islet autoantibody, and progressive beta cell loss are observed concurrently. Moreover, this non-typical diabetes that usually occurs among children and adolescents has been defined as 'double diabetes', and its worldwide incidence has been on the increase as of late. Thus, there has been heightened interest among researchers about this ambiguous condition.

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer