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Glucose Toxicity and Pancreatic Beta Cell Dysfunction in Type 2 Diabetes.
Kyu Chang Won, Ji Sung Yoon
Korean Diabetes J. 2008;32(3):175-181.   Published online June 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.3.175
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AbstractAbstract PDF
The adverse effects of prolonged exposure of pancreatic islets to supraphysiologic glucose concentrations (i.e. glucose toxicity) is mediated at least in part by glucose oxidation and the subsequent generation of reactive oxygen species (ROS) that can impair insulin gene expression and beta cell function. Multiple biochemical pathways and mechanisms of action for glucose toxicity have been suggested. These include glucose autoxidation, protein kinase C activation, methylglyoxal formation and glycation, hexosamine metabolism, sorbitol formation, and oxidative phosphorylation. There are many potential mechanisms whereby excess glucose metabolites traveling along these pathways might cause beta cell damage. However, all these pathways have in common the formation of reactive oxygen species that, in excess and over time, cause chronic oxidative stress, which in turn causes defective insulin gene expression and insulin secretion as well as increased apoptosis. The intracellular peroxide levels of the pancreatic islets (INS-1 cells, rat islets) by flow cytometry were increased in the high glucose media compared to 5.6 mM glucose media. The insulin, MafA, PDX-1 mRNA levels and glucose stimulated insulin secretion (GSIS) were decreased in high glucose media compared to 5.6 mM glucose media. The HO-1 seems to mediate the protective response of pancreatic islets against the oxidative stress that is due to high glucose conditions. Also, we observed decreased glutathione level, gamma-GCS expression and increased oxidized LDL, malondialdehyde level at leukocytes and mesothelial cells from patients with Korean Type 2 Diabetes (esp, poorly controlled patients). In conclusion, this pathophysiologic sequence sets the scene for considering antioxidant therapy as an adjunct in the management of diabetes, especially type 2 Diabetes.

Citations

Citations to this article as recorded by  
  • Factors That Influence Pancreatic Beta Cell Function and Insulin Resistance in Newly Diagnosed Type 2 Diabetes Patients: A Sub-Analysis of the MARCH Trial
    Yan Duan, Jia Liu, Yuan Xu, Ning Yang, Wenying Yang, Guang Wang
    Diabetes Therapy.2018; 9(2): 743.     CrossRef
  • Effects of 8 Weeks Resistance Exercise on GSH, SOD, TBARS Activities and GLUT2 mRNA Expression of Pancreas in OLETF Rats
    Min-Ki Lee, Jin-Hwan Yoon
    The Korean Journal of Physical Education.2017; 56(3): 551.     CrossRef
  • Determining the Factors that Influence the Insulin Requirements in Type 2 Diabetic Patients
    Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
    Endocrinology and Metabolism.2010; 25(2): 110.     CrossRef
  • The Effects of Weight Training by Intensity for 8 Weeks of Metabolic Syndrome Factor Improvement in Overweight High School Students

    Journal of Life Science.2009; 19(4): 492.     CrossRef

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