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Clinical Diabetes & Therapeutics
Association between Serum Selenium Level and the Presence of Diabetes Mellitus: A Meta-Analysis of Observational Studies
Juno Kim, Hye Soo Chung, Min-Kyu Choi, Yong Kyun Roh, Hyung Joon Yoo, Jung Hwan Park, Dong Sun Kim, Jae Myung Yu, Shinje Moon
Diabetes Metab J. 2019;43(4):447-460.   Published online January 2, 2019
DOI: https://doi.org/10.4093/dmj.2018.0123
  • 7,280 View
  • 109 Download
  • 36 Web of Science
  • 36 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Epidemiological studies have suggested an association between selenium (Se) and diabetes mellitus (DM). However, different studies have reported conflicting results. Therefore, we performed a comprehensive meta-analysis to clarify the impact of Se on DM.

Methods

We searched the PubMed database for studies on the association between Se and DM from inception to June 2018.

Results

Twenty articles evaluating 47,930 participants were included in the analysis. The meta-analysis found that high levels of Se were significantly associated with the presence of DM (pooled odds ratios [ORs], 1.88; 95% confidence interval [CI], 1.44 to 2.45). However, significant heterogeneity was found (I2=82%). Subgroup analyses were performed based on the Se measurement methods used in each study. A significant association was found between high Se levels and the presence of DM in the studies that used blood (OR, 2.17; 95% CI, 1.60 to 2.93; I2=77%), diet (OR, 1.61; 95% CI, 1.10 to 2.36; I2=0%), and urine (OR, 1.49; 95% CI, 1.02 to 2.17; I2=0%) as samples to estimate Se levels, but not in studies on nails (OR, 1.24; 95% CI, 0.52 to 2.98; I2=91%). Because of significant heterogeneity in the studies with blood, we conducted a sensitivity analysis and tested the publication bias. The results were consistent after adjustment based on the sensitivity analysis as well as the trim and fill analysis for publication bias.

Conclusion

This meta-analysis demonstrates that high levels of Se are associated with the presence of DM. Further prospective and randomized controlled trials are warranted to elucidate the link better.

Citations

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Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
Bahram Pourghassem Gargari, Parvin Dehghan, Akbar Aliasgharzadeh, Mohammad Asghari Jafar-abadi
Diabetes Metab J. 2013;37(2):140-148.   Published online April 16, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.2.140
  • 9,134 View
  • 130 Download
  • 108 Crossref
AbstractAbstract PDFPubReader   
Background

The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes.

Methods

In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass index <35 kg/m2) with type 2 diabetes were recruited from the Iran Diabetes Society and from endocrinology and metabolism clinics associated with the Tabriz University of Medical Science. The participants were divided into one of two groups in which the participants either received 10 g/day of inulin (intervention, n=24) or maltodextrin (control, n=25) for 2 months. Fasting blood samples were obtained and both glycemic control and antioxidant status were determined at baseline and at the end of the study.

Results

At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups.

Conclusion

Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes.

Citations

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  • A high-protein diet containing inulin/oligofructose supports body weight gain associated with lower energy expenditure and carbohydrate oxidation, and alters faecal microbiota in C57BL/6 mice
    Franziska Koch, Michael Derno, Martina Langhammer, Armin Tuchscherer, Harald M. Hammon, Manfred Mielenz, Cornelia C. Metges, Björn Kuhla
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  • The Effects of Prebiotics and Substances with Prebiotic Properties on Metabolic and Inflammatory Biomarkers in Individuals with Type 2 Diabetes Mellitus: A Systematic Review
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    彰子 古谷
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    International Journal of Biological Macromolecules.2018; 109: 1209.     CrossRef
  • The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men
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  • In vitro and in vivo antioxidant activities of inulin
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    PLOS ONE.2018; 13(2): e0192273.     CrossRef
  • Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
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    Advanced Pharmaceutical Bulletin.2018; 8(4): 565.     CrossRef
  • Protective capabilities of silymarin and inulin nanoparticles against hepatic oxidative stress, genotoxicity and cytotoxicity of Deoxynivalenol in rats
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    Toxicon.2018; 142: 1.     CrossRef
  • Effects of prebiotic inulin addition to low- or high-fat diet on maternal metabolic status and neonatal traits of offspring in a pregnant sow model
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  • Milk Powder Co‐Supplemented with Inulin and Resistant Dextrin Improves Glycemic Control and Insulin Resistance in Elderly Type 2 Diabetes Mellitus: A 12‐Week Randomized, Double‐Blind, Placebo‐Controlled Trial
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  • Beneficial impacts of Lactobacillus plantarum and inulin on hypothalamic levels of insulin, leptin, and oxidative markers in diabetic rats
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  • Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail
    Abed Ghavami, Neda Roshanravan, Shahriar Alipour, Meisam Barati, Behzad Mansoori, Faezeh Ghalichi, Elyas Nattagh- Eshtivan, Alireza Ostadrahimi
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  • Inulin as microencapsulating agent improves physicochemical properties of spray-dried aspalathin-rich green rooibos (Aspalathus linearis) extract with α-glucosidase inhibitory activity
    Neil Miller, Dalene De Beer, Marique Aucamp, Christiaan J. Malherbe, Elizabeth Joubert
    Journal of Functional Foods.2018; 48: 400.     CrossRef
  • A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress
    Javad Heshmati, Farnaz Farsi, Fatemeh Shokri, Mahroo Rezaeinejad, Amir Almasi-Hashiani, Samira Vesali, Mahdi Sepidarkish
    Journal of Functional Foods.2018; 46: 66.     CrossRef
  • Sensory Profiles of Koumiss with added Crude Ingredients extracted from Flaxseed (Linum usitatissimum L.)
    Dong-Hyeon Kim, Dana Jeong, Kwang-Young Song, Jung-Whan Chon, Hyunsook Kim, Kun-Ho Seo
    Journal of Milk Science and Biotechnology.2017; 35(3): 169.     CrossRef
  • Short-chain Fatty Acids: A Link Between Prebiotics And Microbiota In Chronic Kidney Disease
    Marta Esgalhado, Julie A Kemp, Nagila RT Damasceno, Denis Fouque, Denise Mafra
    Future Microbiology.2017; 12(15): 1413.     CrossRef
  • Prebiotics, Prosynbiotics and Synbiotics: Can They Reduce Plasma Oxidative Stress Parameters? A Systematic Review
    Amin Salehi-Abargouei, Reza Ghiasvand, Mitra Hariri
    Probiotics and Antimicrobial Proteins.2017; 9(1): 1.     CrossRef
  • The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akkermansia muciniphila abundance in type 2 diabetes; A randomized, double-blind, placebo-controlled trial
    Neda Roshanravan, Reza Mahdavi, Effat Alizadeh, Abed Ghavami, Yalda Rahbar Saadat, Naimeh Mesri Alamdari, Shahriar Alipour, Mohammad Reza Dastouri, Alireza Ostadrahimi
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  • Regulatory efficacy of fermented plant extract on the intestinal microflora and lipid profile in mildly hypercholesterolemic individuals
    Hui-Fang Chiu, Yen-Jung Chen, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kamesh Venkatakrishnan, Chin-Kun Wang
    Journal of Food and Drug Analysis.2017; 25(4): 819.     CrossRef
  • Manufacture of Functional Koumiss supplemented with Cichorium intybus L. (chicory) Extract - Preliminary Study
    Dong-Hyeon Kim, Dana Jeong, Yong-Taek Oh, Hong-Seok Kim, Yun-Gyeong Kim, Kwang-Young Song, Il-Byung Kang, Young-Ji Kim, Jin-Hyeong Park, Ho-Seok Chang, Hyon-Woo Lim, Jung-Whan Chon, Hyunsook Kim, Dong-Kwan Jeong, Kun-Ho Seo
    Journal of Milk Science and Biotechnology.2017; 35(1): 1.     CrossRef
  • Effects of Probiotic and Prebiotic Supplementation on Leptin, Adiponectin, and Glycemic Parameters in Non-alcoholic Fatty Liver Disease: A Randomized Clinical Trial
    Vahideh Behrouz, Shima Jazayeri, Naheed Aryaeian, Mohamad Javad Zahedi, Fatemeh Hosseini
    Middle East Journal of Digestive Diseases.2017; 9(3): 150.     CrossRef
  • Helianthus tuberosus (Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet
    Naoto Okada, Shinya Kobayashi, Kouta Moriyama, Kohsuke Miyataka, Shinji Abe, Chiemi Sato, Kazuyoshi Kawazoe
    Asian Pacific Journal of Tropical Medicine.2017; 10(5): 439.     CrossRef
  • Galacto-oligosaccharides ameliorate dysbiotic Bifidobacteriaceae decline in Japanese patients with type 2 diabetes
    M. Gonai, A. Shigehisa, I. Kigawa, K. Kurasaki, O. Chonan, T. Matsuki, Y. Yoshida, M. Aida, K. Hamano, Y. Terauchi
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  • Prebiotics in the management of components of the metabolic syndrome
    Sarah O’Connor, Sarah Chouinard-Castonguay, Claudia Gagnon, Iwona Rudkowska
    Maturitas.2017; 104: 11.     CrossRef
  • Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro
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    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
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    Elena Barengolts
    Endocrine Practice.2016; 22(10): 1224.     CrossRef
  • Effects of Inulin Supplementation in Low‐ or High‐Fat Diets on Reproductive Performance of Sows and Antioxidant Defence Capacity in Sows and Offspring
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  • Dietary fibers influence the intestinal SCFAs and plasma metabolites profiling in growing pigs
    W. Wu, J. Xie, H. Zhang
    Food & Function.2016; 7(11): 4644.     CrossRef
  • Freeze-dried egg yolk based extenders containing various antioxidants improve post-thawing quality and incubation resilience of goat spermatozoa
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    Cryobiology.2016; 72(3): 269.     CrossRef
  • Host–microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intake
    Camilla Pedersen, Edith Gallagher, Felicity Horton, Richard J. Ellis, Umer Z. Ijaz, Huihai Wu, Etana Jaiyeola, Onyinye Diribe, Thibaut Duparc, Patrice D. Cani, Glenn R. Gibson, Paul Hinton, John Wright, Roberto La Ragione, M. Denise Robertson
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    Ji Yoo, Sung Kim
    Nutrients.2016; 8(3): 173.     CrossRef
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    Mahdieh Abbasalizad Farhangi, Ahmad Zare Javid, Parvin Dehghan
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  • Resistant dextrin, as a prebiotic, improves insulin resistance and inflammation in women with type 2 diabetes: a randomised controlled clinical trial
    Akbar Aliasgharzadeh, Parvin Dehghan, Bahram Pourghassem Gargari, Mohammad Asghari-Jafarabadi
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    Nicole J. Kellow, Melinda T. Coughlan, Christopher M. Reid
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  • Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial
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Impairment of Insulin Secretion by Fat Overload in Rat Pancreatic Islets and Effects of Antioxidants.
Chul Hee Kim, Chan Hee Kim, Hyeong Kyu Park, Kyo Il Suh, Ki Up Lee
Korean Diabetes J. 2002;26(5):347-356.   Published online October 1, 2002
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AbstractAbstract PDF
BACKGROUND
It has recently been suggested that fat overload on pancreatic beta cells is responsible for the abnormal pattern of insulin secretion in type 2 diabetes mellitus. Antioxidant treatment was reported to preserve beta cell function in animal models of diabetes. This study was undertaken to examine the effects of various free fatty acids and triglyceride on insulin secretion in isolated rat pancreatic islets. In addition, we examined the effects of antioxidants. METHODS: Pancreatic islets of normal Sprague-Dawley rats were isolated by intraductal injection of collagenase and Ficoll-gradient centrifugation. The islets were treated with palmitat0e (C16:0), oleate (C18:1), linoleate (C18:2), and triglyceride emulsions (intralipid) for 72hours. Basal and glucose-stimulated insulin secretions were measured. The effects of the antioxidants, vitamin E, alpha-lipoic acid, and N-acetyl cysteine, were examined on the fat-induced change of insulin secretion. RESULTS: All of the free fatty acids and the triglyceride increased the basal insulin secretion. In contrast, insulin secretion stimulated by 27 mM glucose was significantly decreased after the treatment with free fatty acids or triglycerides. The antioxidant could not prevent the fat-induced inhibition of insulin secretion. CONCLUSION: These results show that various free fatty acids and triglyceride commonly cause defects in insulin secretion. However, we could not confirm the the hypothesis that increased oxidative stress may be involved in the pathogenesis of insulin secretory defect associated with fat overload.
The Effect of alpha-lipoic Acid on Endothelial Dysfunction Induced by Intralipid Infusion in Healthy Volunteers.
Dong Wook Lee, Mi Jung Kim, Hye Soon Kim, Tae Sung Yun, Ho Chan Cho, Sang Jun Lee, Seung Ho Hur, Kyo Cheol Mun, Yong Won Cho, Jae Hoon Bae, In Kyu Lee
Korean Diabetes J. 2002;26(5):336-346.   Published online October 1, 2002
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  • 27 Download
AbstractAbstract PDF
BACKGROUND
Endothelial dysfunciton has been proposed as an early manifestation of atherogenesis. Recently, emerging evidence suggests that hypertriglyceridemia and elevated free fatty acid are important risk factors in the development of atherosclerosis, probably through an increased oxidative stress. To clarify the hypothesis, we evaluated the effect of alpha-lipoic acid (ALA) on the endothelial dysfunction induced by intralipid infusion in healthy volunteers. METHODS: Hypertriglyceridemia and elevated free fatty acids was induced by infusion of intralipid. FMD (Flow-mediated dilation) of the brachial artery was investigated noninvasively by a high-resolution ultrasound technique in 13 young, healthy men without risk factors for coronary heart disease. RESULTS: Plasma triglyceride, free fatty acid and the superoxide anion were increased from 61.7+/-28.8 to 332.6+/-202.5 mg/dL, from 330.7+/-131.1 to 1267.0+/-486.2 microEq/L and from 6.6+/-2.2 to 8.7+/-1.5 X 10(-7)nmol/10(6)cells/30min (vs. basal p<0.001), respectively, following infusion of the intralipid. The FMD was decreased from 10.1+/-3.3 to 7.7+/-3.7% (vs. basal p<0.01) following infusion of the intralipid. After treatment with ALA, the increase in the FMD and the decrease in superoxide anion were significant. CONCLUSION: Acute hypertriglyceridemia, induced by intralipid infusion, is implicated in endothelial dysfunction. This endothelial dysfunction was reversed by treatment with ALA. These results suggest that chronic and repeated hypertriglyceridemia may play important roles in the development of atherosclerosis probably by increasing oxidative stress.

Diabetes Metab J : Diabetes & Metabolism Journal
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