Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
5 "Adipose tissue, brown"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Article
Basic Research
Article image
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes
Junfei Gu, Jiajia Jin, Xiaoyu Ren, Xinjie Zhang, Jiaxuan Li, Xiaowei Wang, Shucui Zhang, Xianlun Yin, Qunye Zhang, Zhe Wang
Received August 16, 2023  Accepted February 7, 2024  Published online May 29, 2024  
DOI: https://doi.org/10.4093/dmj.2023.0278    [Epub ahead of print]
  • 692 View
  • 28 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Metabolic dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), in which the abnormalities in brown adipose tissue (BAT) play important roles. However, the cellular composition and function of BAT as well as its pathological significance in diabetes remain incompletely understood. Our objective is to delineate the single-cell landscape of BAT-derived stromal vascular fraction (SVF) and their characteristic alterations in T2DM rats.
Methods
T2DM was induced in rats by intraperitoneal injection of low-dose streptozotocin and high-fat diet feeding. Single-cell mRNA sequencing was then performed on BAT samples and compared to normal rats to characterize changes in T2DM rats. Subsequently, the importance of key cell subsets in T2DM was elucidated using various functional studies.
Results
Almost all cell types in the BAT-derived SVF of T2DM rats exhibited enhanced inflammatory responses, increased angiogenesis, and disordered glucose and lipid metabolism. The multidirectional differentiation potential of adipose tissue-derived stem cells was also reduced. Moreover, macrophages played a pivotal role in intercellular crosstalk of BAT-derived SVF. A novel Rarres2+macrophage subset promoted the differentiation and metabolic function of brown adipocytes via adipose-immune crosstalk.
Conclusion
BAT SVF exhibited strong heterogeneity in cellular composition and function and contributed to T2DM as a significant inflammation source, in which a novel macrophage subset was identified that can promote brown adipocyte function.
Reviews
Basic Research
Article image
Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
Okamatsu-Ogura Yuko, Masayuki Saito
Diabetes Metab J. 2021;45(6):840-852.   Published online June 25, 2021
DOI: https://doi.org/10.4093/dmj.2020.0291
  • 9,545 View
  • 539 Download
  • 20 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.

Citations

Citations to this article as recorded by  
  • Garlic ( Allium sativum L. ) in diabetes and its complications: Recent advances in mechanisms of action
    Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
    Critical Reviews in Food Science and Nutrition.2024; 64(16): 5290.     CrossRef
  • Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
    Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues
    Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri, Masoud Darabi
    Biochemical Pharmacology.2024; 220: 116012.     CrossRef
  • Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
    Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza‐Mello, Julio Beltrame Daleprane
    Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
  • Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis
    Yanqiu Peng, Lixia Zhao, Min Li, Yunfei Liu, Yuke Shi, Jian Zhang
    Biomolecules.2024; 14(4): 483.     CrossRef
  • Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes
    Kiros Haddish, Jong Won Yun
    Biotechnology and Bioprocess Engineering.2024;[Epub]     CrossRef
  • The role of brown adipose tissue in mediating healthful longevity
    Jie Zhang, Berhanu Geresu Kibret, Dorothy E. Vatner, Stephen F. Vatner
    The Journal of Cardiovascular Aging.2024;[Epub]     CrossRef
  • Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats
    Lili Guan, Lei Zhang, Dezheng Gong, Pengcheng Li, Shengnan Zhu, Jiulan Tang, Man Du, Maokun Zhang, Yuan Zou
    Journal of Pharmacy and Pharmacology.2024;[Epub]     CrossRef
  • N-3 polyunsaturated fatty acids in fat-1 transgenic mice prevent obesity by stimulating the IL-27 signaling pathway
    Jiayao Bai, Yinlin Ge, Changqi Zhao, Liu Yang, Keli Ge, Jinyu Zhang
    Journal of Functional Foods.2024; 118: 106288.     CrossRef
  • Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
    Masayuki Saito, Yuko Okamatsu-Ogura
    The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
    Anju Tsukada, Yuko Okamatsu-Ogura, Emi Futagawa, Yuki Habu, Natsumi Takahashi, Mira Kato-Suzuki, Yuko Kato, Satoshi Ishizuka, Kei Sonoyama, Kazuhiro Kimura
    iScience.2023; 26(7): 107239.     CrossRef
  • In situ fluorescence-photoacoustic measurement of the changes of brown adipose tissue in mice under hindlimb unloading
    Baojie Gong, Jianxin Tang, Xiaoxiao Jiang, Zhe Zhang, Shiying Li, Hongjun Jin, Liming Nie, Guojia Huang
    Journal of Applied Physiology.2023; 135(2): 251.     CrossRef
  • Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
    A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
    Journal of Evolutionary Biochemistry and Physiology.2023; 59(4): 1020.     CrossRef
  • UNCOUPLING PROTEIN UCP1 EXPRESSION DYNAMICS IN ADIPOSE TISSUES OF THE OUTBRED ICR MICE IN POSTNATAL ONTOGENESIS
    A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
    Журнал эволюционной биохимии и физиологии.2023; 59(4): 255.     CrossRef
  • Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis
    Sunghyun Kang, Hwan-Woo Park, Kyung Ho Han
    International Journal of Molecular Sciences.2022; 23(14): 7834.     CrossRef
  • Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
    Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Possible roles of exercise and apelin against pregnancy complications
    Hamed Alizadeh Pahlavani
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Relationships between the expression of adipose genes and profiles of hospitalized dogs
    Yukina Sugiyama, Fumie Shimokawa, Kazutoshi Sugiyama, Takashi Kobayashi, Yusuke Yamashita, Kei Kazama, Ken Onda, Masayuki Funaba, Masaru Murakami
    Veterinary Research Communications.2022; 46(4): 1239.     CrossRef
  • Fruit of Gardenia jasminoides Induces Mitochondrial Activation and Non-Shivering Thermogenesis through Regulation of PPARγ
    Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
    Antioxidants.2021; 10(9): 1418.     CrossRef
Obesity and Metabolic Syndrome
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders
So Hun Kim, Jorge Plutzky
Diabetes Metab J. 2016;40(1):12-21.   Published online January 21, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.12
  • 7,978 View
  • 112 Download
  • 159 Web of Science
  • 162 Crossref
AbstractAbstract PDFPubReader   

Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.

Citations

Citations to this article as recorded by  
  • Modulation of angiogenic switch in reprogramming browning and lipid metabolism in white adipocytes
    Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2024; 1869(1): 159423.     CrossRef
  • Anti-Obesity Effects of GABA in C57BL/6J Mice with High-Fat Diet-Induced Obesity and 3T3-L1 Adipocytes
    Heegu Jin, Hyein Han, Gunju Song, Hyun-Ji Oh, Boo-Yong Lee
    International Journal of Molecular Sciences.2024; 25(2): 995.     CrossRef
  • Citrus aurantium L. and synephrine improve brown adipose tissue function in adolescent mice programmed by early postnatal overfeeding
    Andressa Cardoso Guimarães, Egberto Gaspar de Moura, Stephanie Giannini Silva, Bruna Pereira Lopes, Iala Milene Bertasso, Carla Bruna Pietrobon, Fernanda Torres Quitete, Tayanne de Oliveira Malafaia, Érica Patrícia Garcia Souza, Patrícia Cristina Lisboa,
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Au@16-pH-16/miR-21 mimic nanosystem: An efficient treatment for obesity through browning and thermogenesis induction
    Said Lhamyani, Adriana-Mariel Gentile, María Mengual-Mesa, Elia Grueso, Rosa M. Giráldez-Pérez, José Carlos Fernandez-Garcia, Antonio Vega-Rioja, Mercedes Clemente-Postigo, John R. Pearson, Isabel González-Mariscal, Gabriel Olveira, Francisco-Javier Bermu
    Biomedicine & Pharmacotherapy.2024; 171: 116104.     CrossRef
  • Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type
    Tamara Dakic, Dusan Jeremic, Iva Lakic, Nebojsa Jasnic, Aleksandra Ruzicic, Predrag Vujovic, Tanja Jevdjovic
    Molecular and Cellular Biochemistry.2024;[Epub]     CrossRef
  • Role of micro‐RNAs associated with adipose‐derived extracellular vesicles in metabolic disorders
    Thomas Payet, Elisa Gabinaud, Jean‐François Landrier, Lourdes Mounien
    Obesity Reviews.2024;[Epub]     CrossRef
  • Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway
    Bihe Zeng, Qin Shen, Bo Wang, Xuan Tang, Jiaqi Jiang, Yiming Zheng, Hongbiao Huang, Wenyu Zhuo, Wang Wang, Yang Gao, Xuan Li, Shuhui Wang, Wenjie Li, Guanghui Qian, Jie Qin, Miao Hou, Haitao Lv
    Nutrition & Metabolism.2024;[Epub]     CrossRef
  • Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats
    Lili Guan, Lei Zhang, Dezheng Gong, Pengcheng Li, Shengnan Zhu, Jiulan Tang, Man Du, Maokun Zhang, Yuan Zou
    Journal of Pharmacy and Pharmacology.2024;[Epub]     CrossRef
  • Development of Recombinant High-Density Lipoprotein Platform with Innate Adipose Tissue-Targeting Abilities for Regional Fat Reduction
    Junhua Han, Yingxian Chen, Xiaolong Xu, Qingmeng Li, Xin Xiang, Jianzhong Shen, Xiaowei Ma
    ACS Nano.2024; 18(21): 13635.     CrossRef
  • Neuronostatin regulates proliferation and differentiation of rat brown primary preadipocytes
    Małgorzata Krążek, Tatiana Wojciechowicz, Joanna Fiedorowicz, Mathias Z. Strowski, Krzysztof W. Nowak, Marek Skrzypski
    FEBS Letters.2024;[Epub]     CrossRef
  • UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice
    Qing-Ling Quan, Eun Ju Kim, Sungsoo Kim, Yeon Kyung Kim, Min Hwa Chung, Yu-Dan Tian, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
    Journal of Investigative Dermatology.2024;[Epub]     CrossRef
  • A Newly Synbiotic Combination Alleviates Obesity by Modulating the Gut Microbiota–Fat Axis and Inhibiting the Hepatic TLR4/NF‐κB Signaling Pathway
    Yongbo Kang, Peng Ren, Xiaorong Shen, Xiaoyu Kuang, Xiaodan Yang, Haixia Liu, Huan Yan, Hao Yang, Xing Kang, Zeyuan Ding, Xuguang Luo, Jieqiong Ma, Ying Yang, Weiping Fan
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • Lacticaseibacillus paracasei AO356 ameliorates obesity by regulating adipogenesis and thermogenesis in C57BL/6J male mice
    Young In Kim, Eun-Sook Lee, Eun-Ji Song, Dong-Uk Shin, Ji-Eun Eom, Hee Soon Shin, Jung Eun Kim, Ju Yeoun Oh, Young-Do Nam, So-Young Lee
    Journal of Functional Foods.2023; 101: 105404.     CrossRef
  • Effects of caffeoylquinic acid analogs derived from aerial parts of Artemisia iwayomogi on adipogenesis
    Su-Young Han, Jisu Kim, Bo Kyeong Kim, Wan Kyunn Whang, Hyeyoung Min
    Food Science and Biotechnology.2023; 32(9): 1215.     CrossRef
  • Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
    Mi Jin Choi, Hana Yu, Jea Il Kim, Hee Seo, Ju Gyeong Kim, Seul-Ki Kim, Hak Sung Lee, Hyae Gyeong Cheon
    European Journal of Nutrition.2023; 62(4): 1611.     CrossRef
  • Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome
    Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani
    Laboratory Medicine.2023; 54(5): 457.     CrossRef
  • A Novel Mix of Polyphenols and Micronutrients Reduces Adipogenesis and Promotes White Adipose Tissue Browning via UCP1 Expression and AMPK Activation
    Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di D
    Cells.2023; 12(5): 714.     CrossRef
  • Thromboxane A2-TP axis promotes adipose tissue macrophages M1 polarization leading to insulin resistance in obesity
    Ruijie Xu, Yufeng Dai, Xu Zheng, Yongheng Yan, Zhao He, Hao Zhang, Haitao Li, Wei Chen
    Biochemical Pharmacology.2023; 210: 115465.     CrossRef
  • Green Tea Epigallocatechin Gallate Inhibits Preadipocyte Growth via the microRNA‐let‐7a/HMGA2 Signaling Pathway
    Wen‐Ting Chen, Meei‐Ju Yang, Yi‐Wei Tsuei, Tsung‐Chen Su, An‐Ci Siao, Yow‐Chii Kuo, Ling‐Ru Huang, Yi Chen, Sy‐Jou Chen, Po‐Chuan Chen, Ching‐Feng Cheng, Hui‐Chen Ku, Yung‐Hsi Kao
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment
    Rui-Chian Tang, I-Hsuan Yang, Feng-Huei Lin
    Biomacromolecules.2023; 24(8): 3438.     CrossRef
  • Short-duration cold exposure decreases fasting-induced glucose intolerance but has no effect on resting energy expenditure
    Rima Solianik, Katerina Židonienė, Marius Brazaitis
    Cryobiology.2023; 113: 104564.     CrossRef
  • Caffeine promotes the production of Irisin in muscles and thus facilitates the browning of white adipose tissue
    Chang Liu, Yi Li, Ge Song, Xuehan Li, Songyue Chen, Dixin Zou, Huixin Li, Chengyi Hu, Haotian Zhao, Yi Yan
    Journal of Functional Foods.2023; 108: 105702.     CrossRef
  • Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment
    Ahmed F. El-Yazbi, Mohamed A. Elrewiny, Hosam M. Habib, Ali H. Eid, Perihan A. Elzahhar, Ahmed S.F. Belal
    Molecular Pharmacology.2023; 104(5): 187.     CrossRef
  • Rabbit Meat Extract Induces Browning in 3T3−L1 Adipocytes via the AMP−Activated Protein Kinase Pathway
    In-Seon Bae, Jeong Ah Lee, Soo-Hyun Cho, Hyoun-Wook Kim, Yunseok Kim, Kangmin Seo, Hyun-Woo Cho, Min Young Lee, Ju Lan Chun, Ki Hyun Kim
    Foods.2023; 12(19): 3671.     CrossRef
  • Metabolic-Dysfunction-Associated Steatotic Liver Disease—Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Treatments
    Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama
    International Journal of Molecular Sciences.2023; 24(20): 15473.     CrossRef
  • Brown Fat and Nutrition: Implications for Nutritional Interventions
    Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
    Nutrients.2023; 15(18): 4072.     CrossRef
  • Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases
    Giovanni Martemucci, Giuseppe Fracchiolla, Marilena Muraglia, Roberta Tardugno, Roberta Savina Dibenedetto, Angela Gabriella D’Alessandro
    Antioxidants.2023; 12(12): 2091.     CrossRef
  • Metabolic responses of light and taste receptors – unexpected actions of GPCRs in adipocytes
    Onyinye Nuella Ekechukwu, Mark Christian
    Reviews in Endocrine and Metabolic Disorders.2022; 23(1): 111.     CrossRef
  • The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
    Hui-Chen Ku, Tsai-Yun Chan, Jia-Fang Chung, Yung-Hsi Kao, Ching-Feng Cheng
    Biomedicine & Pharmacotherapy.2022; 145: 112440.     CrossRef
  • Prednisone stimulates white adipocyte browning via β3-AR/p38 MAPK/ERK signaling pathway
    Sulagna Mukherjee, Jong Won Yun
    Life Sciences.2022; 288: 120204.     CrossRef
  • Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice
    Qiyang Chen, Dan Wang, Yue Gu, Zixiao Jiang, Zhiqin Zhou
    The Journal of Nutritional Biochemistry.2022; 101: 108943.     CrossRef
  • Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management
    Sujeong Mun, Kihyun Park, Siwoo Lee
    EPMA Journal.2022; 13(1): 125.     CrossRef
  • Effects of a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Pemafibrate, on Metabolic Parameters: A Retrospective Longitudinal Study
    Hidekatsu Yanai, Hisayuki Katsuyama, Mariko Hakoshima
    Biomedicines.2022; 10(2): 401.     CrossRef
  • Historical and cultural aspects of obesity: From a symbol of wealth and prosperity to the epidemic of the 21st century
    Marta Sumińska, Rafał Podgórski, Klaudia Bogusz‐Górna, Bogda Skowrońska, Artur Mazur, Marta Fichna
    Obesity Reviews.2022;[Epub]     CrossRef
  • Molecular Biological and Clinical Understanding of the Statin Residual Cardiovascular Disease Risk and Peroxisome Proliferator-Activated Receptor Alpha Agonists and Ezetimibe for Its Treatment
    Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
    International Journal of Molecular Sciences.2022; 23(7): 3418.     CrossRef
  • Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice
    Renata Silvério, Robson Barth, Andrea S. Heimann, Patrícia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermúdez-Silva, Alex Rafacho, Emer S. Ferro
    International Journal of Molecular Sciences.2022; 23(8): 4082.     CrossRef
  • Thermogenic T cells: a cell therapy for obesity?
    Ulf H. Beier, Daniel J. Baker, Joseph A. Baur
    American Journal of Physiology-Cell Physiology.2022; 322(6): C1085.     CrossRef
  • Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
    Maria E. C. Bruno, Sujata Mukherjee, Whitney L. Powell, Stephanie F. Mori, Franklyn K. Wallace, Beverly K. Balasuriya, Leon C. Su, Arnold J. Stromberg, Donald A. Cohen, Marlene E. Starr
    GeroScience.2022; 44(3): 1761.     CrossRef
  • Deletion of GPR30 Drives the Activation of Mitochondrial Uncoupling Respiration to Induce Adipose Thermogenesis in Female Mice
    Jing Luo, Yao Wang, Elizabeth Gilbert, Dongmin Liu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes
    Lini Song, Xi Cao, Wenyi Ji, Lili Zhao, Weili Yang, Ming Lu, Jinkui Yang
    European Journal of Pharmacology.2022; 926: 175040.     CrossRef
  • TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation
    Huan Ma, Chengkang He, Li Li, Peng Gao, Zongshi Lu, Yingru Hu, Lijuan Wang, Yu Zhao, Tingbing Cao, Yuanting Cui, Hongting Zheng, Gangyi Yang, Zhencheng Yan, Daoyan Liu, Zhiming Zhu
    International Journal of Obesity.2022; 46(8): 1544.     CrossRef
  • Adapalene induces adipose browning through the RARβ-p38 MAPK-ATF2 pathway
    Na Hyun Lee, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
    Archives of Pharmacal Research.2022; 45(5): 340.     CrossRef
  • Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions
    Francisca M. Acosta, Katerina Stojkova, Jingruo Zhang, Eric Ivan Garcia Huitron, Jean X. Jiang, Christopher R. Rathbone, Eric M. Brey
    Journal of Tissue Engineering.2022; 13: 204173142211093.     CrossRef
  • Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway
    Xin Liu, Yuan Huang, Xu Liang, Qiong Wu, Nan Wang, Li-jun Zhou, Wen-wu Liu, Qun Ma, Bei Hu, Huan Gao, Ya-ling Cui, Xiang Li, Qing-chun Zhao
    Phytomedicine.2022; 104: 154289.     CrossRef
  • The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall
    Cassie Hillock-Watling, Avrum I. Gotlieb
    Cardiovascular Pathology.2022; 61: 107459.     CrossRef
  • RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function
    Pengpeng Zhang, Wenyan Wu, Chaofeng Ma, Chunyu Du, Yueru Huang, Haixia Xu, Cencen Li, Xiaofang Cheng, Ruijie Hao, Yongjie Xu
    Cells.2022; 11(15): 2357.     CrossRef
  • The Effect of Swimming Training with Cinnamon Consumption on β3-AR and ERK2 Gene Expression in the Visceral Adipose Tissue of Diabetic Rats
    Kianoosh Mohammadi, Ali Khajehlandi, Amin Mohammadi
    Gene, Cell and Tissue.2022;[Epub]     CrossRef
  • Of mice and men: Considerations on adipose tissue physiology in animal models of obesity and human studies
    Ioannis G. Lempesis, Dimitrios Tsilingiris, Junli Liu, Maria Dalamaga
    Metabolism Open.2022; 15: 100208.     CrossRef
  • The comparison of the effect of acute moderate and high-intensity exercise on the uncoupling protein -1 secretion
    Desiana Merawati, Sugiharto Sugiharto, Adi Pranoto, Olivia Andiana, Prayogi Dwina Angga
    Jurnal SPORTIF : Jurnal Penelitian Pembelajaran.2022; 8(2): 201.     CrossRef
  • Omega-3 Polyunsaturated Fatty Acids Protect against High-Fat Diet-Induced Morphological and Functional Impairments of Brown Fat in Transgenic Fat-1 Mice
    Lei Hao, Yong-Hui Nie, Chih-Yu Chen, Xiang-Yong Li, Kanakaraju Kaliannan, Jing X. Kang
    International Journal of Molecular Sciences.2022; 23(19): 11903.     CrossRef
  • Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
    Vitor Ferreira, Cintia Folgueira, Maria Guillén, Pablo Zubiaur, Marcos Navares, Assel Sarsenbayeva, Pilar López-Larrubia, Jan W. Eriksson, Maria J. Pereira, Francisco Abad-Santos, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde
    Metabolism.2022; 137: 155335.     CrossRef
  • Okra (Abelmoschus esculentus L. Moench) prevents obesity by reducing lipid accumulation and increasing white adipose browning in high-fat diet-fed mice
    Heegu Jin, Hyun-Ji Oh, Sehaeng Cho, Ok-Hwan Lee, Boo-Yong Lee
    Food & Function.2022; 13(22): 11840.     CrossRef
  • Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans
    Ming Zhou, Tianzhen Wu, Yue Chen, Shixia Xu, Guang Yang, Anne Yoder
    Molecular Biology and Evolution.2022;[Epub]     CrossRef
  • Brown adipose tissue transplantation as a novel alternative to obesity treatment: a systematic review
    Moloud Payab, Mina Abedi, Najmeh Foroughi Heravani, Mahdieh Hadavandkhani, Maryam Arabi, Akram Tayanloo-Beik, Motahareh Sheikh Hosseini, Hadis Gerami, Fateme Khatami, Bagher Larijani, Mohammad Abdollahi, Babak Arjmand
    International Journal of Obesity.2021; 45(1): 109.     CrossRef
  • Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
    Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang
    Pharmacological Research.2021; 164: 105291.     CrossRef
  • Inducible beige adipocytes improve impaired glucose metabolism in interscapular BAT-removal mice
    Xiao-Wei Jia, Dong-Liang Fang, Xin-Yi Shi, Tao Lu, Chun Yang, Yan Gao
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(3): 158871.     CrossRef
  • NNT‐induced tumor cell “slimming” reverses the pro‐carcinogenesis effect of HIF2a in tumors
    Zhiyong Xiong, Wei Xiong, Wen Xiao, Changfei Yuan, Jian Shi, Yu Huang, Cheng Wang, Xiangui Meng, Zhixian Chen, Hongmei Yang, Ke Chen, Xiaoping Zhang
    Clinical and Translational Medicine.2021;[Epub]     CrossRef
  • CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells
    Smarajit Chakraborty, Wee Kiat Ong, Winifred W. Y. Yau, Zhihong Zhou, K. N. Bhanu Prakash, Sue-Anne Toh, Weiping Han, Paul M. Yen, Shigeki Sugii
    Stem Cell Research & Therapy.2021;[Epub]     CrossRef
  • Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential
    Hyeonyeong Im, Ji-Hyun Park, Seowoo Im, Juhyeong Han, Kyungmin Kim, Yun-Hee Lee
    Archives of Pharmacal Research.2021; 44(2): 133.     CrossRef
  • 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
    Kang-Yun Lu, Shinn-Zong Lin, Kingsley Theras Primus Dass, Wei-Ju Lin, Shih-Ping Liu, Horng-Jyh Harn
    Biomedicine & Pharmacotherapy.2021; 139: 111687.     CrossRef
  • Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3
    Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jae‐Young Um
    The FASEB Journal.2021;[Epub]     CrossRef
  • Cajanolactone A, a Stilbenoid From Cajanus canjan (L.) Millsp, Prevents High-Fat Diet-Induced Obesity via Suppressing Energy Intake
    Zhuohui Luo, Jiawen Huang, Zhiping Li, Zhiwen Liu, Linchun Fu, Yingjie Hu, Xiaoling Shen
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review
    Michalina Banaszak, Ilona Górna, Juliusz Przysławski
    Nutrients.2021; 13(6): 2023.     CrossRef
  • Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy
    Yinghan Chan, Sin Wi Ng, Joycelin Zhu Xin Tan, Gaurav Gupta, Poonam Negi, Lakshmi Thangavelu, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Wei Hsum Yap, Sachin Kumar Singh, Vanni Caruso, Kamal Dua, Dinesh Kumar Chellappan
    South African Journal of Botany.2021; 143: 176.     CrossRef
  • Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis
    Michael S. Kuefner, Erin Stephenson, Mladen Savikj, Heather S. Smallwood, Qingming Dong, Christine Payré, Gérard Lambeau, Edwards A. Park
    The FASEB Journal.2021;[Epub]     CrossRef
  • N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes
    Kang-Yun Lu, Kingsley Theras Primus Dass, Shinn-Zong Lin, Yu-Hua Tseng, Shih-Ping Liu, Horng-Jyh Harn
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(12): 159033.     CrossRef
  • Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning
    Jie Li, Qiyang Chen, Xiuming Zhai, Dan Wang, Yujia Hou, Min Tang
    Food Science & Nutrition.2021; 9(12): 6548.     CrossRef
  • Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway
    Ji-Yeon Lee, Minyoung Lee, Ji Young Lee, Jaehyun Bae, Eugene Shin, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Diabetes & Metabolism Journal.2021; 45(6): 921.     CrossRef
  • The increase of uncoupling protein-1 expression after moderate intensity continuous exercises in obese females
    Sugiharto, Banih Sakti Adji, Desiana Merawati, Adi Pranoto
    Jurnal SPORTIF : Jurnal Penelitian Pembelajaran.2021; 7(2): 194.     CrossRef
  • Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity
    Naimeh Mesri Alamdari, Pardis Irandoost, Neda Roshanravan, Mohammadreza Vafa, Mohammad Asghari Jafarabadi, Shahriar Alipour, Leila Roshangar, Mohammadreza Alivand, Farnaz Farsi, Farzad Shidfar
    Nutrition & Metabolism.2020;[Epub]     CrossRef
  • Metabolic Benefits of MicroRNA-22 Inhibition
    Marc Thibonnier, Christine Esau
    Nucleic Acid Therapeutics.2020; 30(2): 104.     CrossRef
  • Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet
    Cecilia Rodriguez Lanzi, Diahann J. Perdicaro, Julián Gambarte Tudela, Victoria Muscia, Ariel R. Fontana, Patricia I. Oteiza, Marcela A. Vazquez Prieto
    Food & Function.2020; 11(2): 1537.     CrossRef
  • Citrus aurantium L. polymethoxyflavones promote thermogenesis of brown and white adipose tissue in high-fat diet induced C57BL/6J mice
    Guangning Kou, Yan Hu, Zixiao Jiang, Zhenqing Li, Peiyuan Li, Hongjie Song, Qiyang Chen, Zhiqin Zhou, Quanjun Lyu
    Journal of Functional Foods.2020; 67: 103860.     CrossRef
  • Beneficial effects of pomegranate peel extract treatment on anthropometry and body composition of overweight patients with diabetes mellitus type-2: A randomised clinical trial
    Milkica Grabež, Ranko Škrbić, Miloš Stojiljković, Vesna Rudić-Grujić, Katarina Šavikin, Nebojša Menković, Gordana Zdunić, Nađa Vasiljević
    Scripta Medica.2020; 51(1): 21.     CrossRef
  • Milk fat globule membrane and its component phosphatidylcholine induce adipose browning both in vivo and in vitro
    Tiange Li, Min Du, Hanning Wang, Xueying Mao
    The Journal of Nutritional Biochemistry.2020; 81: 108372.     CrossRef
  • Dynamic contrast‐enhanced MRI of brown and beige adipose tissues
    Jadegoud Yaligar, Sanjay Kumar Verma, Venkatesh Gopalan, Rengaraj Anantharaj, Giang Thi Thu Le, Kavita Kaur, Karthik Mallilankaraman, MK Leow, SS Velan
    Magnetic Resonance in Medicine.2020; 84(1): 384.     CrossRef
  • Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model
    Kyoung Soo Kim, Hari Madhuri Doss, Hee-Jin Kim, Hyung-In Yang
    Foods.2020; 9(6): 688.     CrossRef
  • White adipose tissue browning in critical illness: A review of the evidence, mechanisms and future perspectives
    Elham Alipoor, Mohammad Javad Hosseinzadeh‐Attar, Mahsa Rezaei, Shima Jazayeri, Marianne Chapman
    Obesity Reviews.2020;[Epub]     CrossRef
  • Metabolic and energetic benefits of microRNA-22 inhibition
    Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker
    BMJ Open Diabetes Research & Care.2020; 8(1): e001478.     CrossRef
  • Apple polyphenols induce browning of white adipose tissue
    Yuki Tamura, Shigeto Tomiya, Junya Takegaki, Karina Kouzaki, Arata Tsutaki, Koichi Nakazato
    The Journal of Nutritional Biochemistry.2020; 77: 108299.     CrossRef
  • Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo
    Kathleen R. Markan, Lauren K. Boland, Abdul Qaadir King-McAlpin, Kristin E. Claflin, Michael P. Leaman, Morgan K. Kemerling, Madison M. Stonewall, Brad A. Amendt, James A. Ankrum, Matthew J. Potthoff
    Molecular Metabolism.2020; 36: 100965.     CrossRef
  • A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances
    Helda Tutunchi, Alireza Ostadrahimi, Mohammad‐Javad Hosseinzadeh‐Attar, Mahsa Miryan, Majid Mobasseri, Mehrangiz Ebrahimi‐Mameghani
    Obesity Reviews.2020;[Epub]     CrossRef
  • Deficiency of glutathione peroxidase-1 and catalase attenuated diet-induced obesity and associated metabolic disorders
    Hyung-Ran Kim, Eun-Jeong Choi, Jeong-Hae Kie, Joo-Ho Lee, Ju-Young Seoh
    Acta Diabetologica.2020; 57(2): 151.     CrossRef
  • Clinical Application Potential of Small Molecules that Induce Brown Adipose Tissue Thermogenesis by Improving Fat Metabolism
    Kang-Yun Lu, Kingsley Theras Primus Dass, Sheng-Feng Tsai, Hong-Meng Chuang, Shinn-Zong Lin, Shih-Ping Liu, Horng-Jyh Harn
    Cell Transplantation.2020; 29: 096368972092739.     CrossRef
  • MiR‐92a regulates brown adipocytes differentiation, mitochondrial oxidative respiration, and heat generation by targeting SMAD7
    Zhipin Zhang, Huixin Jiang, Xiang Li, Xiaomin Chen, Yihua Huang
    Journal of Cellular Biochemistry.2020; 121(8-9): 3825.     CrossRef
  • Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α
    Darren M. Gordon, Kari L. Neifer, Abdul-Rizaq Ali Hamoud, Charles F. Hawk, Andrea L. Nestor-Kalinoski, Scott A. Miruzzi, Michael P. Morran, Samuel O. Adeosun, Jeffrey G. Sarver, Paul W. Erhardt, Robert E. McCullumsmith, David E. Stec, Terry D. Hinds
    Journal of Biological Chemistry.2020; 295(29): 9804.     CrossRef
  • The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans
    Oana C Kulterer, Laura Niederstaetter, Carsten T Herz, Alexander R Haug, Andrea Bileck, Dietmar Pils, Alexandra Kautzky-Willer, Christopher Gerner, Florian W Kiefer
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(7): 2203.     CrossRef
  • Downregulation of osteopontin inhibits browning of white adipose tissues through PI3K-AKT pathway in C57BL / 6 mice
    Yi Lu, Yuhong Xu, Wanwan Yuan, Mengxi Wang, Yumeng Zhou, Kai Chen, Qiren Huang
    European Journal of Pharmacology.2020; 866: 172822.     CrossRef
  • Angiotensin AT1 receptor antagonism by losartan stimulates adipocyte browning via induction of apelin
    Dong Young Kim, Mi Jin Choi, Tae Kyung Ko, Na Hyun Lee, Ok-Hee Kim, Hyae Gyeong Cheon
    Journal of Biological Chemistry.2020; 295(44): 14878.     CrossRef
  • Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition
    Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Sang Woo Kim
    Molecules.2020; 25(23): 5660.     CrossRef
  • In vitro evaluation of Hydrilla verticillata for anti-adipogenesis activity on 3T3 L1 cell lines
    SPandi Prabha, S Sadhana, C Karthik, DG Caroline
    Pharmacognosy Magazine.2020; 16(5): 498.     CrossRef
  • Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
    Jie Wang, Jing Ge, Haigang Cao, Xiaoyu Zhang, Yuan Guo, Xiao Li, Bo Xia, Gongshe Yang, Xin’e Shi
    Cells.2019; 8(4): 372.     CrossRef
  • Impact of Gut Microbiota on Host Glycemic Control
    Céline Gérard, Hubert Vidal
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity
    Oh Yoen Kim, Ji Yeon Chung, Juhyun Song
    Pharmacological Research.2019; 148: 104411.     CrossRef
  • A comprehensive diagnostic approach to detect underlying causes of obesity in adults
    Eline S. van der Valk, Erica L.T. van den Akker, Mesut Savas, Lotte Kleinendorst, Jenny A. Visser, Mieke M. Van Haelst, Arya M. Sharma, Elisabeth F.C. van Rossum
    Obesity Reviews.2019; 20(6): 795.     CrossRef
  • Prostacyclin: A major prostaglandin in the regulation of adipose tissue development
    Mohammad Sharifur Rahman
    Journal of Cellular Physiology.2019; 234(4): 3254.     CrossRef
  • The expression of brown fat‐associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis
    Abdo Alnabulsi, Beatriz Cash, Yehfang Hu, Linda Silina, Ayham Alnabulsi, Graeme I. Murray
    International Journal of Cancer.2019; 145(4): 1138.     CrossRef
  • Garlic augments the functional and nutritional behavior of Doenjang, a traditional Korean fermented soybean paste
    Ashutosh Bahuguna, Shruti Shukla, Jong Suk Lee, Vivek K. Bajpai, So-Young Kim, Yun Suk Huh, Young-Kyu Han, Myunghee Kim
    Scientific Reports.2019;[Epub]     CrossRef
  • Clomiphene promotes browning of white adipocytes via casein kinase-2 inhibition
    Hyun-Jin Kim, Dong Young Kim, Hyae Gyeong Cheon
    European Journal of Pharmacology.2019; 861: 172596.     CrossRef
  • Neuroendocrine Regulation of Energy Metabolism Involving Different Types of Adipose Tissues
    Qi Zhu, Bradley J. Glazier, Benjamin C. Hinkel, Jingyi Cao, Lin Liu, Chun Liang, Haifei Shi
    International Journal of Molecular Sciences.2019; 20(11): 2707.     CrossRef
  • Tumor Cell “Slimming” Regulates Tumor Progression through PLCL1/UCP1‐Mediated Lipid Browning
    Zhiyong Xiong, Wen Xiao, Lin Bao, Wei Xiong, Haibing Xiao, Yan Qu, Changfei Yuan, Hailong Ruan, Qi Cao, Keshan Wang, Zhengshuai Song, Cheng Wang, Wenjun Hu, Zeyuan Ru, Junwei Tong, Gong Cheng, Tianbo Xu, Xiangui Meng, Jian Shi, Zhixian Chen, Hongmei Yang,
    Advanced Science.2019;[Epub]     CrossRef
  • Soyasaponin Ab alleviates postmenopausal obesity through browning of white adipose tissue
    Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee Do
    Journal of Functional Foods.2019; 57: 453.     CrossRef
  • Beneficial Effects of Pomegranate Peel Extract and Probiotics on Pre-adipocyte Differentiation
    Valeria Sorrenti, Cinzia Lucia Randazzo, Cinzia Caggia, Gabriele Ballistreri, Flora Valeria Romeo, Simona Fabroni, Nicolina Timpanaro, Marco Raffaele, Luca Vanella
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Visfatin; a potential novel mediator of brown adipose tissue
    Parmida Pourvali-Talatappeh, Elham Alipoor
    Obesity Medicine.2019; 15: 100122.     CrossRef
  • Strategies and methods for the correction of obesity and associated cardiovascular risk
    T. Yu. Kuznetsova, M. A. Druzhilov, G. A. Chumakova, N. D. Veselovskaya
    Russian Journal of Cardiology.2019; (4): 61.     CrossRef
  • Polymeric Carriers for Controlled Drug Delivery in Obesity Treatment
    Di Huang, Meng Deng, Shihuan Kuang
    Trends in Endocrinology & Metabolism.2019; 30(12): 974.     CrossRef
  • Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway
    Wei Sun, Xuemei Zhao, Zhengqi Wang, Yi Chu, Liufeng Mao, Shaoqiang Lin, Xuefei Gao, Yuna Song, Xiaoyan Hui, Shiqi Jia, Shibing Tang, Yong Xu, Aimin Xu, Kerry Loomes, Cunchuan Wang, Donghai Wu, Tao Nie
    Molecular Metabolism.2019; 28: 48.     CrossRef
  • Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice
    Kyung-Ah Park, Zhen Jin, Hyeong Seok An, Jong Youl Lee, Eun Ae Jeong, Eun Bee Choi, Kyung Eun Kim, Hyun Joo Shin, Jung Eun Lee, Gu Seob Roh
    The Korean Journal of Physiology & Pharmacology.2019; 23(5): 335.     CrossRef
  • Peripherally administered melanocortins induce mice fat browning and prevent obesity
    Adriana R. Rodrigues, Maria J. Salazar, Sílvia Rocha-Rodrigues, Inês O. Gonçalves, Célia Cruz, Delminda Neves, Henrique Almeida, José Magalhães, Alexandra M. Gouveia
    International Journal of Obesity.2019; 43(5): 1058.     CrossRef
  • Chinese medicine Jinlida granules improve high-fat-diet induced metabolic disorders via activation of brown adipose tissue in mice
    Hui Zhang, Yuanyuan Hao, Cong Wei, Bing Yao, Shen Liu, Hongru Zhou, Dan Huang, Chuanhai Zhang, Yiling Wu
    Biomedicine & Pharmacotherapy.2019; 114: 108781.     CrossRef
  • Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
    G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
    International Journal of Obesity.2018; 42(3): 542.     CrossRef
  • Air Pollution Has a Significant Negative Impact on Intentional Efforts to Lose Weight: A Global Scale Analysis
    Morena Ustulin, So Young Park, Sang Ouk Chin, Suk Chon, Jeong-taek Woo, Sang Youl Rhee
    Diabetes & Metabolism Journal.2018; 42(4): 320.     CrossRef
  • Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet
    Fenglin Zhang, Wei Ai, Xiaoquan Hu, Yingying Meng, Cong Yuan, Han Su, Lina Wang, Xiaotong Zhu, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
    Food & Function.2018; 9(4): 2043.     CrossRef
  • Nobiletin induces brown adipocyte-like phenotype and ameliorates stress in 3T3-L1 adipocytes
    Jameel Lone, Hilal Ahmad Parray, Jong Won Yun
    Biochimie.2018; 146: 97.     CrossRef
  • Regular aerobic exercise correlates with reduced anxiety and incresed levels of irisin in brain and white adipose tissue
    Nazan Uysal, Oguz Yuksel, Servet Kizildag, Zeynep Yuce, Hikmet Gumus, Aslı Karakilic, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates
    Neuroscience Letters.2018; 676: 92.     CrossRef
  • The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice
    Mi Song, Soo-Kyoung Lim, Jing-Hua Wang, Hojun Kim
    International Journal of Molecular Sciences.2018; 19(1): 278.     CrossRef
  • Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice
    Tamiris Lima Rachid, Flavia Maria Silva-Veiga, Francielle Graus-Nunes, Isabele Bringhenti, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello, Nobuyuki Takahashi
    PLOS ONE.2018; 13(1): e0191365.     CrossRef
  • Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes
    Linkang Zhou, Miao Yu, Muhammad Arshad, Wenmin Wang, Ye Lu, Jingyi Gong, Yangnan Gu, Peng Li, Li Xu
    Diabetes.2018; 67(10): 1935.     CrossRef
  • Lithocholic Acid Improves the Survival of Drosophila Melanogaster
    Stefanie Staats, Gerald Rimbach, Axel Kuenstner, Simon Graspeuntner, Jan Rupp, Hauke Busch, Christian Sina, Ignacio R. Ipharraguerre, Anika E. Wagner
    Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
  • Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue
    Songpei Li, Xiu Zhou, Eunjung Jo, Ali Mahzari, Sherouk Fouda, Dongli Li, Kun Zhang, Ji-Ming Ye
    Bioscience Reports.2018;[Epub]     CrossRef
  • Alternative mRNA Splicing in the Pathogenesis of Obesity
    Chi-Ming Wong, Lu Xu, Mabel Yau
    International Journal of Molecular Sciences.2018; 19(2): 632.     CrossRef
  • Krüppel-Like Factors
    Nina M. Pollak, Matthew Hoffman, Ira J. Goldberg, Konstantinos Drosatos
    JACC: Basic to Translational Science.2018; 3(1): 132.     CrossRef
  • Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
    Stefanie Worsch, Mathias Heikenwalder, Hans Hauner, Bernhard L. Bader
    Nutrition & Metabolism.2018;[Epub]     CrossRef
  • Combination of Capsaicin and Hesperidin Reduces the Effectiveness of Each Compound To Decrease the Adipocyte Size and To Induce Browning Features in Adipose Tissue of Western Diet Fed Rats
    Andrea Mosqueda-Solís, Juana Sánchez, María P. Portillo, Andreu Palou, Catalina Picó
    Journal of Agricultural and Food Chemistry.2018; 66(37): 9679.     CrossRef
  • Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
    Robin van Eenige, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman
    Trends in Endocrinology & Metabolism.2018; 29(5): 326.     CrossRef
  • Cardiovascular and Metabolic Heterogeneity of Obesity
    Ian J. Neeland, Paul Poirier, Jean-Pierre Després
    Circulation.2018; 137(13): 1391.     CrossRef
  • Zinc alpha2 glycoprotein promotes browning in adipocytes
    Xin-Hua Xiao, Xiao-Yan Qi, Ya-Di Wang, Li Ran, Jing Yang, Huan-Li Zhang, Can-Xin Xu, Ge-Bo Wen, Jiang-Hua Liu
    Biochemical and Biophysical Research Communications.2018; 496(2): 287.     CrossRef
  • Impacts of High Sodium Intake on Obesity-related Gene Expression
    Minjee Lee, Miyoung Park, Juhee Kim, Soyoung Sung, Myoungsook Lee
    Journal of the East Asian Society of Dietary Life.2018; 28(5): 364.     CrossRef
  • Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
    Perla P. Argentato, Helena de Cássia César, Débora Estadella, Luciana P. Pisani
    British Journal of Nutrition.2018; 120(6): 619.     CrossRef
  • Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice
    Zili Wang, Brian T. Feeley, Hubert T. Kim, Xuhui Liu
    Clinical Orthopaedics & Related Research.2018; 476(8): 1665.     CrossRef
  • Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study
    Gyuri Kim, Seung-Eun Lee, Ji Eun Jun, You-Bin Lee, Jiyeon Ahn, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon-Kyu Lee, Jae Hyeon Kim
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice
    Tao Hu, Xiaoxue Yuan, Gang Wei, Haoshu Luo, Hyuek Jong Lee, Wanzhu Jin
    European Journal of Nutrition.2018; 57(1): 391.     CrossRef
  • Effects of growth hormone on uncoupling protein 1 in white adipose tissues in obese mice
    Misa Hayashi, Kumi Futawaka, Rie Koyama, Yue Fan, Midori Matsushita, Asuka Hirao, Yuki Fukuda, Ayako Nushida, Syoko Nezu, Tetsuya Tagami, Kenji Moriyama
    Growth Hormone & IGF Research.2017; 37: 31.     CrossRef
  • Position paper of the European Society of Cardiology–working group of coronary pathophysiology and microcirculation: obesity and heart disease
    Lina Badimon, Raffaele Bugiardini, Edina Cenko, Judit Cubedo, Maria Dorobantu, Dirk J. Duncker, Ramón Estruch, Davor Milicic, Dimitris Tousoulis, Zorana Vasiljevic, Gemma Vilahur, Cor de Wit, Akos Koller
    European Heart Journal.2017; 38(25): 1951.     CrossRef
  • Browning of Abdominal Aorta Perivascular Adipose Tissue Inhibits Adipose Tissue Inflammation
    Run-Mei Li, Sui-Qing Chen, Ning-Xi Zeng, Shu-Hui Zheng, Li Guan, Hai-Mei Liu, Le-Quan Zhou, Jin-Wen Xu
    Metabolic Syndrome and Related Disorders.2017; 15(9): 450.     CrossRef
  • The role of adipose tissue in cancer-associated cachexia
    Janina A Vaitkus, Francesco S Celi
    Experimental Biology and Medicine.2017; 242(5): 473.     CrossRef
  • Hormonal factors in the control of the browning of white adipose tissue
    Jiamiao Hu, Mark Christian
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
    Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Adem
    Redox Biology.2017; 13: 94.     CrossRef
  • Resveratrol enhances brown adipocyte formation and function by activating AMP‐activated protein kinase (AMPK) α1 in mice fed high‐fat diet
    Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Adipoz doku ve enerji metabolizması üzerine etkileri
    Meltem Mermer, Nilüfer Acar TEK
    SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
  • Physiological roles of macrophages
    Siamon Gordon, Luisa Martinez-Pomares
    Pflügers Archiv - European Journal of Physiology.2017; 469(3-4): 365.     CrossRef
  • Brown Adipose Tissue Bioenergetics: A New Methodological Approach
    María Calderon‐Dominguez, Martín Alcalá, David Sebastián, Antonio Zorzano, Marta Viana, Dolors Serra, Laura Herrero
    Advanced Science.2017;[Epub]     CrossRef
  • Honokiol exerts dual effects on browning and apoptosis of adipocytes
    Jameel Lone, Jong Won Yun
    Pharmacological Reports.2017; 69(6): 1357.     CrossRef
  • The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice
    Miyoung Song
    Journal of Korean Medicine for Obesity Research.2017; 17(2): 119.     CrossRef
  • Brown Adipose Tissue: an Update on Recent Findings
    Kara L. Marlatt, Eric Ravussin
    Current Obesity Reports.2017; 6(4): 389.     CrossRef
  • Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism
    Yin Li, Xin Liu, Yu Fan, Baican Yang, Cheng Huang
    PeerJ.2017; 5: e3305.     CrossRef
  • Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling
    Shannon H. Carroll, Ellen Zhang, Bing F. Wang, Katherine B. LeClair, Arifeen Rahman, David E. Cohen, Jorge Plutzky, Parth Patwari, Richard T. Lee, Makoto Kanzaki
    PLOS ONE.2017; 12(3): e0173823.     CrossRef
  • Effect of Long-Term Green Tea Extract Supplementation on Peripheral Blood Leukocytes in CrossFit-Trained and Untrained Men
    Agata Żak, Ilona Pokora
    Central European Journal of Sport Sciences and Medicine.2017; 19: 67.     CrossRef
  • Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa
    Lingyu Zhang, Dan Wang, Min Wen, Lei Du, Changhu Xue, Jingfeng Wang, Jie Xu, Yuming Wang
    Journal of Functional Foods.2017; 28: 28.     CrossRef
  • Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
    Cécile Milet, Marianne Bléher, Kassandra Allbright, Mickael Orgeur, Fanny Coulpier, Delphine Duprez, Emmanuelle Havis
    Scientific Reports.2017;[Epub]     CrossRef
  • Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders
    Marco Tozzi, Ivana Novak
    Frontiers in Pharmacology.2017;[Epub]     CrossRef
  • Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice
    Eunju Kim, Soo-Min Lim, Min-Soo Kim, Sang-Ho Yoo, Yuri Kim
    Nutrients.2017; 9(10): 1049.     CrossRef
  • Yogurt and Cardiometabolic Diseases: A Critical Review of Potential Mechanisms
    Melissa Anne Fernandez, Shirin Panahi, Noémie Daniel, Angelo Tremblay, André Marette
    Advances in Nutrition.2017; 8(6): 812.     CrossRef
  • Système endocannabinoïde : effets sur le métabolisme glucidique, mais aussi lipidique
    A.-L. Sberna, P. Degrace, B. Vergès
    Médecine des Maladies Métaboliques.2016; 10(5): 407.     CrossRef
  • The Fat Side of the Endocannabinoid System: Role of Endocannabinoids in the Adipocyte
    Isabelle Matias, Ilaria Belluomo, Daniela Cota
    Cannabis and Cannabinoid Research.2016; 1(1): 176.     CrossRef
  • Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathwayin vivoandin vitro
    Endong Zhu, Yang Yang, Juanjuan Zhang, Yongmei Li, Chunjun Li, Liming Chen, Bei Sun
    Oncotarget.2016; 7(49): 81077.     CrossRef
  • NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
    Zhongshu Li, Shenghu Feng, Li Zhou, Shunai Liu, Jun Cheng
    Biochemical and Biophysical Research Communications.2016; 475(1): 133.     CrossRef
  • Novel device for male infertility screening with single-ball lens microscope and smartphone
    Yoshitomo Kobori, Peter Pfanner, Gail S. Prins, Craig Niederberger
    Fertility and Sterility.2016; 106(3): 574.     CrossRef
  • An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
    Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson
    Gastroenterology.2016; 151(5): 845.     CrossRef
  • Feast and famine: Adipose tissue adaptations for healthy aging
    Daniele Lettieri Barbato, Katia Aquilano
    Ageing Research Reviews.2016; 28: 85.     CrossRef
  • Hypothalamus and thermogenesis: Heating the BAT, browning the WAT
    Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Gema Medina-Gómez, Miguel López
    Molecular and Cellular Endocrinology.2016; 438: 107.     CrossRef
  • Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes
    Yung-Li Wang, Shih-Pei Lin, Patrick C.H. Hsieh, Shih-Chieh Hung
    Biochemical and Biophysical Research Communications.2016; 478(2): 689.     CrossRef
The Mechanism of White and Brown Adipocyte Differentiation
Hironori Nakagami
Diabetes Metab J. 2013;37(2):85-90.   Published online April 16, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.2.85
  • 4,561 View
  • 101 Download
  • 29 Web of Science
  • 29 Crossref
AbstractAbstract PDFPubReader   

Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of metabolic syndrome can well be understood by studying the molecular mechanisms that control the development and function of adipose tissue. In human body, exist two types of adipose tissue, the white and the brown one, which are reported to play various roles in energy homeostasis. The major and most efficient storage of energy occurs in the form of triglycerides in white adipose tissue while brown adipose tissue actively participates in both basal and inducible energy consumption in the form of thermogenesis. Recent years have observed a rapid and greater interest towards developmental plasticity and therapeutic potential of stromal cells those isolated from adipose tissue. The adipocyte differentiation involves a couple of regulators in the white or brown adipogenesis. Peroxisome proliferators-activated receptor-γ actively participates in regulating carbohydrate and lipid metabolism, and also acts as main regulator of both white and brown adipogenesis. This review based on our recent research, seeks to highlight the adipocyte differentiation.

Citations

Citations to this article as recorded by  
  • ZNF217: An Oncogenic Transcription Factor and Potential Therapeutic Target for Multiple Human Cancers
    Yepeng Wang, Chao Ma, Xuekun Yang, Jun Gao, Zhigang Sun
    Cancer Management and Research.2024; Volume 16: 49.     CrossRef
  • Neuronostatin regulates proliferation and differentiation of rat brown primary preadipocytes
    Małgorzata Krążek, Tatiana Wojciechowicz, Joanna Fiedorowicz, Mathias Z. Strowski, Krzysztof W. Nowak, Marek Skrzypski
    FEBS Letters.2024;[Epub]     CrossRef
  • COBL, MKX and MYOC Are Potential Regulators of Brown Adipose Tissue Development Associated with Obesity-Related Metabolic Dysfunction in Children
    Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. Heiker, Wieland Kiess, Antje Körner, Kathrin Landgraf
    International Journal of Molecular Sciences.2023; 24(4): 3085.     CrossRef
  • Identification of Biochemical Differences in White and Brown Adipocytes Using FTIR Spectroscopy
    DongHyun Shon, SeJun Park, SukJun Yoon, Yong Ko
    Applied Sciences.2022; 12(6): 3071.     CrossRef
  • Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity
    Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y Zhu, Zhi Liu, Clinton Robbins, Dana J Philpott, Stephen E Girardin, Amira Kl
    eLife.2022;[Epub]     CrossRef
  • Direct Conversion of Human Fibroblasts into Adipocytes Using a Novel Small Molecular Compound: Implications for Regenerative Therapy for Adipose Tissue Defects
    Yoshihiro Sowa, Tsunao Kishida, Fiona Louis, Seiji Sawai, Makoto Seki, Toshiaki Numajiri, Kenji Takahashi, Osam Mazda
    Cells.2021; 10(3): 605.     CrossRef
  • The Role of Peptide Hormones Discovered in the 21st Century in the Regulation of Adipose Tissue Functions
    Paweł A. Kołodziejski, Ewa Pruszyńska-Oszmałek, Tatiana Wojciechowicz, Maciej Sassek, Natalia Leciejewska, Mariami Jasaszwili, Maria Billert, Emilian Małek, Dawid Szczepankiewicz, Magdalena Misiewicz-Mielnik, Iwona Hertig, Leszek Nogowski, Krzysztof W. No
    Genes.2021; 12(5): 756.     CrossRef
  • Critical roles of microRNA-196 in normal physiology and non-malignant diseases: Diagnostic and therapeutic implications
    Milad Bastami, Andrea Masotti, Zahra Saadatian, Abdolreza Daraei, Mojtaba Farjam, Ali Ghanbariasad, Sepideh Zununi Vahed, Shirin Eyvazi, Yaser Mansoori, Ziba Nariman-Saleh-Fam
    Experimental and Molecular Pathology.2021; 122: 104664.     CrossRef
  • Whole genome sequencing reveals a complex introgression history and the basis of adaptation to subarctic climate in wild sheep
    Maulik Upadhyay, Elisabeth Kunz, Edson Sandoval‐Castellanos, Andreas Hauser, Stefan Krebs, Alexander Graf, Helmut Blum, Arsen Dotsev, Innokentiy Okhlopkov, Alexey Shakhin, Vugar Bagirov, Gottfried Brem, Ruedi Fries, Natalia Zinovieva, Ivica Medugorac
    Molecular Ecology.2021; 30(24): 6701.     CrossRef
  • microRNAs in Human Adipose Tissue Physiology and Dysfunction
    Alina Kurylowicz
    Cells.2021; 10(12): 3342.     CrossRef
  • Multiple roles of HOX proteins in Metastasis: Let me count the ways
    Joy Jonkers, Priya Pai, Saraswati Sukumar
    Cancer and Metastasis Reviews.2020; 39(3): 661.     CrossRef
  • Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets
    Vanessa R. Williams, Ana Konvalinka, Xuewen Song, Xiaohua Zhou, Rohan John, York Pei, James W. Scholey
    Kidney International.2020; 98(1): 116.     CrossRef
  • NOTCH Receptors and DLK Proteins Enhance Brown Adipogenesis in Mesenchymal C3H10T1/2 Cells
    María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Beatriz Sánchez-Solana, Eva-María Monsalve, María-José M. Díaz-Guerra, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón
    Cells.2020; 9(9): 2032.     CrossRef
  • Early-life programming of adipose tissue
    Ericka Moreno-Mendez, Saray Quintero-Fabian, Cristina Fernandez-Mejia, Maria-Luisa Lazo-de-la-Vega-Monroy
    Nutrition Research Reviews.2020; 33(2): 244.     CrossRef
  • Nanotechnology‐Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities
    Yung‐Hao Tsou, Bin Wang, William Ho, Bin Hu, Pei Tang, Sydney Sweet, Xue‐Qing Zhang, Xiaoyang Xu
    Advanced Healthcare Materials.2019;[Epub]     CrossRef
  • ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner
    Qing Liu, Yuanling Zhao, Ruifan Wu, Qin Jiang, Min Cai, Zhen Bi, Youhua Liu, Yongxi Yao, Jie Feng, Yizhen Wang, Xinxia Wang
    RNA Biology.2019; 16(12): 1785.     CrossRef
  • Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
    Yea Eun Kang, Hyun Jin Kim, Minho Shong
    Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
  • DLK proteins modulate NOTCH signaling to influence a brown or white 3T3-L1 adipocyte fate
    María-Luisa Nueda, María-Julia González-Gómez, María-Milagros Rodríguez-Cano, Eva-María Monsalve, María José M. Díaz-Guerra, Beatriz Sánchez-Solana, Jorge Laborda, Victoriano Baladrón
    Scientific Reports.2018;[Epub]     CrossRef
  • Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes
    Juan Carlos Higareda-Almaraz, Michael Karbiener, Maude Giroud, Florian M. Pauler, Teresa Gerhalter, Stephan Herzig, Marcel Scheideler
    BMC Genomics.2018;[Epub]     CrossRef
  • MicroRNAs and adipocytokines: Promising biomarkers for pharmacological targets in diabetes mellitus and its complications
    Mohamad Reza Ashoori, Mohammad Rahmati-Yamchi, Alireza Ostadrahimi, Sedigheh Fekri Aval, Nosratollah Zarghami
    Biomedicine & Pharmacotherapy.2017; 93: 1326.     CrossRef
  • The Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARG) in Adipogenesis: Applying Knowledge from the Fish Aquaculture Industry to Biomedical Research
    Rebecca Wafer, Panna Tandon, James E. N. Minchin
    Frontiers in Endocrinology.2017;[Epub]     CrossRef
  • Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
    Marie Pigeyre, Fereshteh T. Yazdi, Yuvreet Kaur, David Meyre
    Clinical Science.2016; 130(12): 943.     CrossRef
  • Metformin-suppressed differentiation of human visceral preadipocytes: Involvement of microRNAs
    Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Kayo Hirose, Miwako Watanabe, Teppei Sakamoto, Akiko Katsura, Shima Mimura, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Keiichi Okano, Yasuyuki Suzuki, Takashi
    International Journal of Molecular Medicine.2016; 38(4): 1135.     CrossRef
  • Platycodon grandiflorum A. De Candolle Ethanolic Extract Inhibits Adipogenic Regulators in 3T3-L1 Cells and Induces Mitochondrial Biogenesis in Primary Brown Preadipocytes
    Hye-Lin Kim, Jinbong Park, Hyewon Park, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Mi-Young Jeong, Jae-Young Um
    Journal of Agricultural and Food Chemistry.2015; 63(35): 7721.     CrossRef
  • New genetic loci link adipose and insulin biology to body fat distribution
    Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph M. W. Wu, Martin L. Buchkovich, Nancy L. Heard-
    Nature.2015; 518(7538): 187.     CrossRef
  • Oxidative stress, redox regulation and diseases of cellular differentiation
    Zhi-Wei Ye, Jie Zhang, Danyelle M. Townsend, Kenneth D. Tew
    Biochimica et Biophysica Acta (BBA) - General Subjects.2015; 1850(8): 1607.     CrossRef
  • Nutraceuticals and regulation of adipocyte life: Premises or promises
    Monica Colitti, Stefano Grasso
    BioFactors.2014; 40(4): 398.     CrossRef
  • BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathway
    Yin Mai, Zhenyu Zhang, Hao Yang, Peiyue Dong, Guiyan Chu, Gongshe Yang, Shiduo Sun
    Biochemistry and Cell Biology.2014; 92(3): 172.     CrossRef
  • The HOX genes network in metabolic diseases
    Alfredo Procino, Clemente Cillo
    Cell Biology International.2013; 37(11): 1145.     CrossRef
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Masayuki Saito
Diabetes Metab J. 2013;37(1):22-29.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.22
  • 6,024 View
  • 86 Download
  • 91 Crossref
AbstractAbstract PDFPubReader   

Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.

Citations

Citations to this article as recorded by  
  • Taraxacum mongolicum polysaccharide promotes white adipocyte browning by regulating miR-134-3p via Akt/GSK-3β signalling
    Xiaoyu Yue, Ling Zhong, Mengyan Ye, Yue Luan, Qiang Zhang, Qin Wang
    International Journal of Biological Macromolecules.2024; 257: 128296.     CrossRef
  • Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
    Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • Nuciferine prevents obesity by activating brown adipose tissue
    Chunlong Yan, Yang Zhan, Shouli Yuan, Yujing Cao, Yi Chen, Meng Dong, Hanlin Zhang, Li Chen, Rui Jiang, Wenjun Liu, Wanzhu Jin, Yuanyuan Huang
    Food & Function.2024; 15(2): 967.     CrossRef
  • Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy
    Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
    Nutrients.2024; 16(4): 513.     CrossRef
  • CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury
    Matthieu Leuillier, Thomas Duflot, Séverine Ménoret, Hind Messaoudi, Zoubir Djerada, Déborah Groussard, Raphaël G.P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiébaut, Isabelle Schmitz-Afonso, Séverine Nobis, Cynthia Campart,
    Journal of Advanced Research.2023; 43: 163.     CrossRef
  • Metabolic effects of lipectomy and of adipose tissue transplantation
    Sarah Davis, Samantha Hocking, Matthew J. Watt, Jenny E. Gunton
    Obesity.2023; 31(1): 7.     CrossRef
  • Modulation of the thermosensory system by oxytocin
    Ugo Zayan, Laura Caccialupi Da Prato, Françoise Muscatelli, Valéry Matarazzo
    Frontiers in Molecular Neuroscience.2023;[Epub]     CrossRef
  • Regenerative Medicine for Polycystic Ovary Syndrome: Stem Cell-Based Therapies and Brown Adipose Tissue Activation
    Mario Karam, Hélène Najjar, Marwan El Sabban, Aline Hamade, Fadia Najjar
    Stem Cell Reviews and Reports.2023; 19(4): 853.     CrossRef
  • Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
    Masayuki Saito, Yuko Okamatsu-Ogura
    The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
  • p27Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice
    Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martinez, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
    International Journal of Molecular Sciences.2023; 24(3): 2664.     CrossRef
  • Energy metabolism and thermoregulation during sleep in young and old females
    Jaehoon Seol, Chihiro Kokudo, Insung Park, Simeng Zhang, Katsuhiko Yajima, Tomohiro Okura, Kumpei Tokuyama
    Scientific Reports.2023;[Epub]     CrossRef
  • Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model
    Marcos David Munoz, Alexa Zamudio, Maximilian McCann, Victoria Gil, Pingwen Xu, Chong Wee Liew
    Scientific Reports.2023;[Epub]     CrossRef
  • Ado-Mediated Depletion of Taurine Impairs Mitochondrial Respiratory Capacity and Alters the Chromatin Landscape of Inguinal Adipose Tissue
    Pei-Yin Tsai, Bo Shui, Seoyeon Lee, Yang Liu, Yue Qu, Chloe Cheng, Kaydine Edwards, Callie Wong, Ryan Meng-Killeen, Paul D. Soloway, Joeva J. Barrow
    Nutrients.2023; 15(16): 3532.     CrossRef
  • Metabolic associated fatty liver disease is a disease related to sympathetic nervous system activation
    Zhao-Chun Chi
    World Chinese Journal of Digestology.2022; 30(11): 465.     CrossRef
  • Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy
    Stefan Tholen, Roma Patel, Agnieszka Agas, Kyle M. Kovary, Atefeh Rabiee, Hayley T. Nicholls, Ewa Bielczyk-Maczyńska, Wenting Yang, Fredric B. Kraemer, Mary N. Teruel
    Cell Reports.2022; 39(13): 111018.     CrossRef
  • KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure
    Ju-hong Jang, Jeong Woong Lee, Min Ji Cho, Byungtae Hwang, Min-Gi Kwon, Dong-Hwan Kim, Nam-Kyung Lee, Jangwook Lee, Young-Jun Park, Yong Ryoul Yang, Jinchul Kim, Yong-Hoon Kim, Tae Hyeon An, Kyoung-Jin Oh, Kwang-Hee Bae, Jong-Gil Park, Jeong-Ki Min
    Experimental & Molecular Medicine.2022; 54(8): 1250.     CrossRef
  • Brown fat-associated postprandial thermogenesis in humans: Different effects of isocaloric meals rich in carbohydrate, fat, and protein
    Sayuri Aita, Mami Matsushita, Takeshi Yoneshiro, Takuya Hatano, Toshimitsu Kameya, Iwao Ohkubo, Masayuki Saito
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans
    Anna Borup, Ida Donkin, Mariëtte R. Boon, Martin Frydland, Borja Martinez-Tellez, Annika Loft, Sune H. Keller, Andreas Kjaer, Jesper Kjaergaard, Christian Hassager, Romain Barrès, Patrick C. N. Rensen, Christina Christoffersen
    Scientific Reports.2022;[Epub]     CrossRef
  • Signaling Pathways Regulating Thermogenesis
    Chihiro Tabuchi, Hei Sook Sul
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice
    Yejin Jeon, Ji-Young Choi, Eun-Hwa Jang, Je Kyung Seong, Kyunglim Lee
    International Journal of Obesity.2021; 45(7): 1576.     CrossRef
  • Diurnal variations of brown fat thermogenesis and fat oxidation in humans
    Mami Matsushita, Shinsuke Nirengi, Masanobu Hibi, Hitoshi Wakabayashi, Sang-il Lee, Masayuki Domichi, Naoki Sakane, Masayuki Saito
    International Journal of Obesity.2021; 45(11): 2499.     CrossRef
  • Adipose browning response to burn trauma is impaired with aging
    Abdikarim Abdullahi, Carly M. Knuth, Christopher Auger, Thibacg Sivayoganathan, Alexandra Parousis, Marc G. Jeschke
    JCI Insight.2021;[Epub]     CrossRef
  • The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
    Chang-Hyung Lee, Young-A Choi, Sung-Jin Heo, Parkyong Song
    International Journal of Environmental Research and Public Health.2021; 18(17): 9165.     CrossRef
  • Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
    Okamatsu-Ogura Yuko, Masayuki Saito
    Diabetes & Metabolism Journal.2021; 45(6): 840.     CrossRef
  • Comparative Transcriptome Profiling of Young and Old Brown Adipose Tissue Thermogenesis
    Yumin Kim, Baeki E. Kang, Dongryeol Ryu, So Won Oh, Chang-Myung Oh
    International Journal of Molecular Sciences.2021; 22(23): 13143.     CrossRef
  • Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring
    Tiange Li, Han Gong, Qichen Yuan, Min Du, Fazheng Ren, Xueying Mao
    The FASEB Journal.2020; 34(3): 4619.     CrossRef
  • Nicotine exposure during breastfeeding reduces sympathetic activity in brown adipose tissue and increases in white adipose tissue in adult rats: Sex-related differences
    T.C. Peixoto, E.G. Moura, P.N. Soares, I.M. Bertasso, C.B. Pietrobon, F.A.H. Caramez, R.A. Miranda, E. Oliveira, A.C. Manhães, P.C. Lisboa
    Food and Chemical Toxicology.2020; 140: 111328.     CrossRef
  • Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice
    Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
    Cell Reports.2020; 33(1): 108237.     CrossRef
  • Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via β3-adrenergic Receptor-p38 MAPK Signaling Pathway
    Subramani Manigandan, Jong Won Yun
    Biotechnology and Bioprocess Engineering.2020; 25(3): 345.     CrossRef
  • Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men
    Masayuki Saito, Mami Matsushita, Takeshi Yoneshiro, Yuko Okamatsu-Ogura
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Differences in [18F]FDG uptake in BAT of UCP1 −/− and UCP1 +/+ during adrenergic stimulation of non-shivering thermogenesis
    Christian T. McHugh, John Garside, Jared Barkes, Jonathan Frank, Constance Dragicevich, Hong Yuan, Rosa T. Branca
    EJNMMI Research.2020;[Epub]     CrossRef
  • Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?
    Ineke H.N. Luijten, Barbara Cannon, Jan Nedergaard
    Molecular Aspects of Medicine.2019; 68: 42.     CrossRef
  • Sexual Dimorphism of Brown Adipose Tissue Function
    Lindsay J. Robinson, James Law, Valerie Astle, Marta Gutiérrez-García, Shalini Ojha, Michael E. Symonds, Nicola Pitchford, Helen Budge
    The Journal of Pediatrics.2019; 210: 166.     CrossRef
  • Cold Induced Depot-Specific Browning in Ferret Aortic Perivascular Adipose Tissue
    Bàrbara Reynés, Evert M. van Schothorst, Jaap Keijer, Enzo Ceresi, Paula Oliver, Andreu Palou
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism
    Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi, Shimpei Ushio
    Nutrition & Metabolism.2019;[Epub]     CrossRef
  • Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice
    Gabriela Cavazza Cerri, Leandro Ceotto Freitas Lima, Deborah de Farias Lelis, Lucíola da Silva Barcelos, John David Feltenberger, Samuel Vidal Mussi, Renato Sobral Monteiro-Junior, Robson Augusto Souza dos Santos, Lucas Antônio Miranda Ferreira, Sérgio He
    Life Sciences.2019; 218: 292.     CrossRef
  • Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway
    Qinyang Jiang, Xiaofang Cheng, Yueyue Cui, Qin Xia, Xueyu Yan, Mingyuan Zhang, Ganqiu Lan, Jiaqi Liu, Tizhong Shan, Yanna Huang
    Food & Function.2019; 10(6): 3334.     CrossRef
  • Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
    Yea Eun Kang, Hyun Jin Kim, Minho Shong
    Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
  • Inter‐organ communication: a gatekeeper for metabolic health
    Judit Castillo‐Armengol, Lluis Fajas, Isabel C Lopez‐Mejia
    EMBO reports.2019;[Epub]     CrossRef
  • Clinical Implications of UCP1 mRNA Expression in Human Cervical Adipose Tissue Under Physiological Conditions
    Ju Hee Lee, Ji Min Kim, Min Jeong Choi, Yea Eun Kang, Kyoung Hye Joung, Hyon‐Seung Yi, Koon Soon Kim, Bon Jeong Ku, Bon Seok Koo, Minho Shong, Hyun Jin Kim
    Obesity.2018; 26(6): 1008.     CrossRef
  • Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance
    Kenneth D’Souza, Geena Paramel, Petra Kienesberger
    Nutrients.2018; 10(4): 399.     CrossRef
  • Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
    Clément Pierre, Florent Guillebaud, Coraline Airault, Nathalie Baril, Rym Barbouche, Etienne Save, Stéphanie Gaigé, Bruno Bariohay, Michel Dallaporta, Jean-Denis Troadec
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes
    Kanae Nakamura, Tsunao Kishida, Akika Ejima, Riho Tateyama, Satoru Morishita, Tomoji Ono, Michiaki Murakoshi, Keikichi Sugiyama, Hoyoku Nishino, Osam Mazda
    BioMetals.2018; 31(3): 415.     CrossRef
  • Association of wrist and ambient temperature with cold-induced brown adipose tissue and skeletal muscle [18F]FDG uptake in young adults
    Borja Martinez-Tellez, Huiwen Xu, Guillermo Sanchez-Delgado, Francisco M. Acosta, Patrick C. N. Rensen, Jose M. Llamas-Elvira, Jonatan R. Ruiz
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1281.     CrossRef
  • Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
    Yongguo Li, Katharina Schnabl, Sarah-Madeleine Gabler, Monja Willershäuser, Josefine Reber, Angelos Karlas, Sanna Laurila, Minna Lahesmaa, Mueez u Din, Andrea Bast-Habersbrunner, Kirsi A. Virtanen, Tobias Fromme, Florian Bolze, Libbey S. O’Farrell, Jorge
    Cell.2018; 175(6): 1561.     CrossRef
  • Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
    G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
    International Journal of Obesity.2018; 42(3): 542.     CrossRef
  • Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans
    Daniel C. Berry, Yuwei Jiang, Robert W. Arpke, Elizabeth L. Close, Aki Uchida, David Reading, Eric D. Berglund, Michael Kyba, Jonathan M. Graff
    Cell Metabolism.2017; 25(1): 166.     CrossRef
  • Postprandial Increase in Energy Expenditure Correlates with Body Weight Reduction in Patients with Type 2 Diabetes Receiving Diet Therapy
    Daisuke Sanoyama, Mototsugu Nagao, Akira Asai, Yuko Nakamura, Kazumi Sato, Yasushi Nakajima, Shinichi Oikawa, Hitoshi Sugihara
    Journal of Atherosclerosis and Thrombosis.2017; 24(4): 422.     CrossRef
  • Physiological regulation and metabolic role of browning in white adipose tissue
    Aleksandra Jankovic, Vesna Otasevic, Ana Stancic, Biljana Buzadzic, Aleksandra Korac, Bato Korac
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • Resveratrol enhances brown adipocyte formation and function by activating AMP‐activated protein kinase (AMPK) α1 in mice fed high‐fat diet
    Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
    Daniela Guarino, Monica Nannipieri, Giorgio Iervasi, Stefano Taddei, Rosa Maria Bruno
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Adipoz doku ve enerji metabolizması üzerine etkileri
    Meltem Mermer, Nilüfer Acar TEK
    SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
  • Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans
    Takayuki Nishimura, Takafumi Katsumura, Midori Motoi, Hiroki Oota, Shigeki Watanuki
    Scientific Reports.2017;[Epub]     CrossRef
  • Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation
    Yuwei Jiang, Daniel C Berry, Jonathan M Graff
    eLife.2017;[Epub]     CrossRef
  • Ovarian hormones and obesity
    Brigitte Leeners, Nori Geary, Philippe N. Tobler, Lori Asarian
    Human Reproduction Update.2017; 23(3): 300.     CrossRef
  • Nutritional approaches for managing obesity-associated metabolic diseases
    Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li, Chaodong Wu
    Journal of Endocrinology.2017; 233(3): R145.     CrossRef
  • Lower core body temperature and greater body fat are components of a human thrifty phenotype
    M Reinhardt, M Schlögl, S Bonfiglio, S B Votruba, J Krakoff, M S Thearle
    International Journal of Obesity.2016; 40(5): 754.     CrossRef
  • Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans
    Aleix Gavaldà-Navarro, José M. Moreno-Navarrete, Tania Quesada-López, Montserrat Cairó, Marta Giralt, José M. Fernández-Real, Francesc Villarroya
    Diabetologia.2016; 59(10): 2208.     CrossRef
  • Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function
    Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff
    Nature Communications.2016;[Epub]     CrossRef
  • Control of human energy expenditure by cytochrome c oxidase subunit IV-2
    Tomas A. Schiffer, Maria Peleli, Michaela L. Sundqvist, Björn Ekblom, Jon O. Lundberg, Eddie Weitzberg, Filip J. Larsen
    American Journal of Physiology-Cell Physiology.2016; 311(3): C452.     CrossRef
  • Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species
    Lars Rebiger, Sigurd Lenzen, Ilir Mehmeti
    Bioscience Reports.2016;[Epub]     CrossRef
  • Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
    Mark J.W. Hanssen, Anouk A.J.J. van der Lans, Boudewijn Brans, Joris Hoeks, Kelly M.C. Jardon, Gert Schaart, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
    Diabetes.2016; 65(5): 1179.     CrossRef
  • Phytochemicals as novel agents for the induction of browning in white adipose tissue
    Yusra Azhar, Ashish Parmar, Colette N. Miller, Janaiya S. Samuels, Srujana Rayalam
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Energy expenditure and intake during puberty in healthy nonobese adolescents: a systematic review
    Hoi Lun Cheng, Mazen Amatoury, Katharine Steinbeck
    The American Journal of Clinical Nutrition.2016; 104(4): 1061.     CrossRef
  • MRI characterization of brown adipose tissue in obese and normal-weight children
    Jie Deng, Samantha E. Schoeneman, Huiyuan Zhang, Soyang Kwon, Cynthia K. Rigsby, Richard M. Shore, Jami L. Josefson
    Pediatric Radiology.2015; 45(11): 1682.     CrossRef
  • A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
    Martin Reinhardt, Marie S. Thearle, Mostafa Ibrahim, Maximilian G. Hohenadel, Clifton Bogardus, Jonathan Krakoff, Susanne B. Votruba
    Diabetes.2015; 64(8): 2859.     CrossRef
  • Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
    S Wang, X Liang, Q Yang, X Fu, C J Rogers, M Zhu, B D Rodgers, Q Jiang, M V Dodson, M Du
    International Journal of Obesity.2015; 39(6): 967.     CrossRef
  • Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
    Masayuki Saito
    The Korean Journal of Obesity.2015; 24(1): 1.     CrossRef
  • Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes
    Colette N. Miller, Jeong-Yeh Yang, Emily England, Amelia Yin, Clifton A. Baile, Srujana Rayalam, Graça Soveral
    PLOS ONE.2015; 10(9): e0138344.     CrossRef
  • Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity
    M. Luisa Bonet, Jose A. Canas, Joan Ribot, Andreu Palou
    Archives of Biochemistry and Biophysics.2015; 572: 112.     CrossRef
  • Calorie hoarding and thrifting: Foxa3 finds a way
    Xinran Ma, Lingyan Xu, Elisabetta Mueller
    Adipocyte.2015; 4(4): 325.     CrossRef
  • Can thermogenic adipocytes protect from obesity?
    L. N. Medvedev, E. I. Elsukova
    Journal of Physiology and Biochemistry.2015; 71(4): 847.     CrossRef
  • Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice
    Yuko Okamatsu-Ogura, Ayumi Tsubota, Kana Ohyama, Yoshihito Nogusa, Masayuki Saito, Kazuhiro Kimura
    Journal of Functional Foods.2015; 19: 1.     CrossRef
  • Energy Expenditure in Humans and Other Primates: A New Synthesis
    Herman Pontzer
    Annual Review of Anthropology.2015; 44(1): 169.     CrossRef
  • Gene expression of peripheral blood mononuclear cells is affected by cold exposure
    Bàrbara Reynés, Estefanía García-Ruiz, Paula Oliver, Andreu Palou
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R824.     CrossRef
  • Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
    PLOS ONE.2015; 10(11): e0141724.     CrossRef
  • Food Ingredients as Anti-Obesity Agents
    Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
    Trends in Endocrinology & Metabolism.2015; 26(11): 585.     CrossRef
  • Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity
    Yumie Morimoto-Kobayashi, Kazuaki Ohara, Chika Takahashi, Sayoko Kitao, Guanying Wang, Yoshimasa Taniguchi, Mikio Katayama, Katsuya Nagai, Qinghua Sun
    PLOS ONE.2015; 10(6): e0131042.     CrossRef
  • Role of forkhead box protein A3 in age-associated metabolic decline
    Xinran Ma, Lingyan Xu, Oksana Gavrilova, Elisabetta Mueller
    Proceedings of the National Academy of Sciences.2014; 111(39): 14289.     CrossRef
  • Thermoneutrality results in prominent diet‐induced body weight differences in C57BL/6J mice, not paralleled by diet‐induced metabolic differences
    Femke P. M. Hoevenaars, Melissa Bekkenkamp‐Grovenstein, Rolf J. R. J. Janssen, Sandra G. Heil, Annelies Bunschoten, Elise F. Hoek‐van den Hil, Sophie Snaas‐Alders, Katja Teerds, Evert M. van Schothorst, Jaap Keijer
    Molecular Nutrition & Food Research.2014; 58(4): 799.     CrossRef
  • Vijftig tinten vet
    Mattees van Dijk
    Tijdschrift voor praktijkondersteuning.2014; 9(6): 170.     CrossRef
  • MRI detection of brown adipose tissue with low fat content in newborns with hypothermia
    Houchun H. Hu, Tai-Wei Wu, Larry Yin, Mimi S. Kim, Jonathan M. Chia, Thomas G. Perkins, Vicente Gilsanz
    Magnetic Resonance Imaging.2014; 32(2): 107.     CrossRef
  • The origin and definition of brite versus white and classical brown adipocytes
    Matthias Rosenwald, Christian Wolfrum
    Adipocyte.2014; 3(1): 4.     CrossRef
  • Expression of “brown-in-white” adipocyte biomarkers shows gender differences and the influence of early dietary exposure
    María Servera, Nora López, Francisca Serra, Andreu Palou
    Genes & Nutrition.2014;[Epub]     CrossRef
  • Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
    Paul Lee, Sheila Smith, Joyce Linderman, Amber B. Courville, Robert J. Brychta, William Dieckmann, Charlotte D. Werner, Kong Y. Chen, Francesco S. Celi
    Diabetes.2014; 63(11): 3686.     CrossRef
  • Food Function Study of Obesity and Fat Energy Metabolism
    Teruo Kawada
    Nippon Eiyo Shokuryo Gakkaishi.2014; 67(3): 119.     CrossRef
  • Kaempferia parviflora extract increases energy consumption through activation of BAT in mice
    Susumu Yoshino, Minji Kim, Riyo Awa, Hiroshige Kuwahara, Yuriko Kano, Teruo Kawada
    Food Science & Nutrition.2014; 2(6): 634.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2013; 32(6): 397.     CrossRef
  • Ghrelin
    Geetali Pradhan, Susan L. Samson, Yuxiang Sun
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 619.     CrossRef
  • Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management
    Takeshi Yoneshiro, Masayuki Saito
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 625.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular.2013; 32(6): 397.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer