Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal



Page Path
HOME > Search
5 "AMPK"
Article category
Publication year
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
Hayley M. O'Neill
Diabetes Metab J. 2013;37(1):1-21.   Published online February 15, 2013
  • 9,676 View
  • 152 Download
  • 182 Crossref
AbstractAbstract PDFPubReader   

AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).


Citations to this article as recorded by  
  • Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPARα in the liver and muscles of high fat diet-fed rats
    Zakiah N. Almohawes, Attalla El-Kott, Kareem Morsy, Ali A. Shati, Ayman E. El-Kenawy, Heba S. Khalifa, Fahmy G. Elsaid, Abd-El-Karim M. Abd-Lateif, Ahmed Abu-Zaiton, Eman R. Ebealy, Mohamed M. Abdel-Daim, Reham A. Ghanem, Eman M. Abd-Ella
    Archives of Physiology and Biochemistry.2024; 130(3): 257.     CrossRef
  • Molecular mechanisms underlying sarcopenia in heart failure
    Cody A. Rutledge
    The Journal of Cardiovascular Aging.2024;[Epub]     CrossRef
  • Diarrhea induced by insufficient fat absorption in weaned piglets: Causes and nutrition regulation
    Yuying Li, Pengjun Shi, Kang Yao, Qian Lin, Mansheng Wang, Zhenping Hou, Wenjie Tang, Hui Diao
    Animal Nutrition.2024; 16: 299.     CrossRef
  • Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
    Abduldaheem Turki Jalil, Hassan Hadi Al-Kazzaz, Firas A. Hassan, Safaa Halool Mohammed, Muna S. Merza, Tahani Aslandook, Ahmed Elewadi, Ali Fadhil, Ali Alsalamy
    Indian Journal of Clinical Biochemistry.2024;[Epub]     CrossRef
  • Small peptides: could they have a big role in metabolism and the response to exercise?
    Muhammed M. Atakan, İbrahim Türkel, Berkay Özerkliğ, Şükran N. Koşar, Dale F. Taylor, Xu Yan, David J. Bishop
    The Journal of Physiology.2024; 602(4): 545.     CrossRef
  • The genetic and dietary landscape of the muscle insulin signalling network
    Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
    eLife.2024;[Epub]     CrossRef
  • Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation
    Liang Wang, Yang Qiao, Jingzhi Yu, Qihao Wang, Xinyu Wu, Qiqi Cao, Zeyu Zhang, Zhen Feng, Huan He
    Redox Biology.2024; 70: 103079.     CrossRef
  • The genetic and dietary landscape of the muscle insulin signalling network
    Julian van Gerwen, Stewart WC Masson, Harry B Cutler, Alexis Diaz Vegas, Meg Potter, Jacqueline Stöckli, Søren Madsen, Marin E Nelson, Sean J Humphrey, David E James
    eLife.2024;[Epub]     CrossRef
  • AMPK activation modulates IL‐36‐induced inflammatory responses by regulating IκBζ expression in the skin
    Yi‐Ting Huang, Ling‐Ya Chiu, Po‐Hsuan Lu, Pa‐Fan Hsiao, Jen‐Yu Wang, Ping‐Hsun Lu, Nan‐Lin Wu
    British Journal of Pharmacology.2024;[Epub]     CrossRef
  • Harmine alleviated STZ-induced rat diabetic nephropathy: A potential role via regulating AMPK/Nrf2 pathway and deactivating ataxia-telangiectasia mutated (ATM) signaling
    Manar Mohammed El Tabaa, Maram Mohammed El Tabaa, Eman Rashad, Mohammed Salah Elballal, Ola Elazazy
    International Immunopharmacology.2024; 132: 111954.     CrossRef
  • Exercise-Mediated Protection against Air Pollution-Induced Immune Damage: Mechanisms, Challenges, and Future Directions
    Xingsheng Jin, Yang Chen, Bingxiang Xu, Haili Tian
    Biology.2024; 13(4): 247.     CrossRef
  • The beneficial effects of metformin inclusion on growth performance, glucose utilization, antioxidant capacity and apoptosis of largemouth bass (Micropterus salmoides) fed with high dietary carbohydrates
    Xiaoyuan Wang, Ye Gong, Wenfei Li, Ning Liu, Zishuo Fang, Nihe Zhang, Naisong Chen, Songlin Li
    Aquaculture.2024; 588: 740957.     CrossRef
  • Anthracycline Cardiotoxicity Induces Progressive Changes in Myocardial Metabolism and Mitochondrial Quality Control
    Anabel Díaz-Guerra, Rocío Villena-Gutiérrez, Agustín Clemente-Moragón, Mónica Gómez, Eduardo Oliver, Miguel Fernández-Tocino, Carlos Galán-Arriola, Laura Cádiz, Borja Ibáñez
    JACC: CardioOncology.2024; 6(2): 217.     CrossRef
  • Potentilla fulgens upregulate GLUT4, AMPK, AKT and insulin in alloxan-induced diabetic mice: an in vivo and in silico study
    Daiahun Thabah, Donkupar Syiem, Careen Liza Pakyntein, Sagnik Banerjee, Cynthia Erica Kharshiing, Atanu Bhattacharjee
    Archives of Physiology and Biochemistry.2023; 129(5): 1071.     CrossRef
  • The importance of AMPK in obesity and chronic diseases and the relationship of AMPK with nutrition: a literature review
    Eren Canbolat, Funda Pınar Cakıroglu
    Critical Reviews in Food Science and Nutrition.2023; 63(4): 449.     CrossRef
  • Hydrogen Sulfide Regulates Glucose Uptake in Skeletal Muscles via S-Sulfhydration of AMPK in Muscle Fiber Type-Dependent Way
    Kelin Li, Minghui Wang, Ruxia Wang, Xiaojuan Wang, Hongchao Jiao, Jingpeng Zhao, Yunlei Zhou, Haifang Li, Hai Lin
    The Journal of Nutrition.2023; 153(10): 2878.     CrossRef
  • Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
    Ishitha Reddy, Yamini Yadav, Chinmoy Sankar Dey
    Cellular and Molecular Neurobiology.2023; 43(4): 1551.     CrossRef
  • Gene expression profile analysis unravelled the systems level association of renal cell carcinoma with diabetic nephropathy and Matrix-metalloproteinase-9 as a potential therapeutic target
    Aditya Rao, Pavan Gollapalli, Nandini Prasad Shetty
    Journal of Biomolecular Structure and Dynamics.2023; 41(16): 7535.     CrossRef
  • Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
    Ha-Thanh-Tung Pham, Eun-Jin Park, Byeol Ryu, Hee-Ju Lee, Thi-Phuong Doan, Hyo-Moon Cho, Thi-Linh-Giang Pham, Won-Keun Oh
    Phytochemistry.2023; 205: 113513.     CrossRef
  • The combination of exercise and metformin inhibits TGF-β1/Smad pathway to attenuate myocardial fibrosis in db/db mice by reducing NF-κB–mediated inflammatory response
    Jingjing Liu, Jiao Lu, Liumei Zhang, Yuting Liu, Yuan Zhang, Yaran Gao, Xinmeng Yuan, Mengqi Xiang, Qiang Tang
    Biomedicine & Pharmacotherapy.2023; 157: 114080.     CrossRef
  • Recent advances in sea cucumber peptide: Production, bioactive properties, and prospects
    Jiacong Man, A. M. Abd El‐Aty, Zuzhe Wang, Mingqian Tan
    Food Frontiers.2023; 4(1): 131.     CrossRef
  • Betulinic Acid: Triterpenoid Derivative Induced NADPH-d Expression in the Urinary System with a Possible Renal Protective Role of Nitric Oxide
    Soo Yue Yin, Siddiqua Ayesha, Chellasamy Panneerselvam, Adel Ibrahim Alalawy, Fahad Mohamed Almutairi, Mohamed Ali Seyed
    Drugs and Drug Candidates.2023; 2(1): 52.     CrossRef
  • Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review
    Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou, Baoan Chen
    Biomolecules.2023; 13(2): 250.     CrossRef
  • The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
    Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
    Nutrients.2023; 15(7): 1660.     CrossRef
  • Modulation of GPC-4 and GPLD1 serum levels by improving glycemic indices in type 2 diabetes: Resistance training and hawthorn extract intervention
    Ali Heidarianpour, Maryam Keshvari, Siamak Shahidi, Mohammad Zarei
    Heliyon.2023; 9(4): e15537.     CrossRef
  • Oral administration of wild plant‐derived minerals and red ginseng ameliorates insulin resistance in fish through different pathways
    Kiyomi Takase, Izuru Kakuta
    Physiological Reports.2023;[Epub]     CrossRef
  • Anti‐fatigue properties of the ethanol extract of Moringa oleifera leaves in mice
    Xiangyu Bian, Yawen Wang, Renren Yang, Yuying Ma, Weiyun Dong, Changjiang Guo, Weina Gao
    Journal of the Science of Food and Agriculture.2023; 103(11): 5500.     CrossRef
  • AMP-activated protein kinase: An energy sensor and survival mechanism in the reinstatement of metabolic homeostasis
    Ankita Sharma, Sumit Kr Anand, Neha Singh, Upendra Nath Dwivedi, Poonam Kakkar
    Experimental Cell Research.2023; 428(1): 113614.     CrossRef
  • Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells
    Caizhu Wang, Ruqin Lin, Xueying Qi, Qiang Xu, Xingsheng Sun, Yurong Zhao, Tianqing Jiang, Jun Jiang, Yu Sun, Yiqun Deng, Jikai Wen
    Biochemical Pharmacology.2023; 214: 115645.     CrossRef
  • Gαi‐coupled GPR41 activation increases Ca2+ influx in C2C12 cells and shows a therapeutic effect in diabetic animals
    Do‐Hyung Lee, Kyung‐Sun Heo, Chang‐Seon Myung
    Obesity.2023; 31(7): 1871.     CrossRef
  • Sapogeninas de Chenopodium quinoa Willd como activadores potenciales de AMPKβ2 para la homeostasis independiente de insulina
    Ricardo Enrique Grados Torrez, Dayana Pamela Bello- Kopa, Ricardo Enrique Grados-Torrez
    Gaceta Médica Boliviana.2023; 46(1): 6.     CrossRef
  • Potential mechanisms of multimodal prehabilitation effects on surgical complications: a narrative review
    Daniel Sibley, Maggie Chen, Malcolm A West, Andrew G Matthew, Daniel Santa Mina, Ian Randall
    Applied Physiology, Nutrition, and Metabolism.2023; 48(9): 639.     CrossRef
  • Insights into the molecular mechanism of muscle textural quality improvement treated by exercise using comparative transcriptome analysis on the hybrid (Erythroculter ilishaeformis ♀ × Ancherythroculter nigrocauda ♂)
    Lang Zhang, Huijie Wei, Yali Yu, Qing Li, Ziwei Song, Yanhong Sun, Pei Li, Jian Chen, Jinhua Gan, Hui Zhang, Xiaorong Lu, Guiying Wang, Li He
    Aquaculture Reports.2023; 31: 101672.     CrossRef
  • Risks and benefits of salicylates in food: a narrative review
    Joanna Suliburska, Rafsan Syabani Cholik
    Nutrition Reviews.2023;[Epub]     CrossRef
  • Nrf2 modulates the benefits of evening exercise in type 2 diabetes
    Babatunde Fasipe, Ismail Laher
    Sports Medicine and Health Science.2023; 5(4): 251.     CrossRef
  • Effectiveness of Combined Aerobic and Resistance Exercise on Cognition, Metabolic Health, Physical Function, and Health-related Quality of Life in Middle-aged and Older Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
    Jinghua Zhang, Wilson Wai San Tam, Kanokwan Hounsri, Joji Kusuyama, Vivien Xi Wu
    Archives of Physical Medicine and Rehabilitation.2023;[Epub]     CrossRef
  • Early postnatal overnutrition impairs VO2max gains with moderate exercise and increase post-exercise muscle damage in adult male rats
    Douglas Lopes Almeida, Gabriel Sergio Fabricio, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Camila Cristina Ianoni Matiusso, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Audrei Pavanello, Ananda Malta, Kesia Palma-Rigo, Paulo Cezar de F
    Journal of Developmental Origins of Health and Disease.2022; 13(3): 406.     CrossRef
  • Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function
    Xue Wang, Yu-ting Zhu, Yi Zhu, Yan-ling Sun, Jun Huang, Zhe Li, Yan Wang, Jun-chao Wu, Zheng-hong Qin, Fang Lin
    Acta Pharmacologica Sinica.2022; 43(4): 850.     CrossRef
  • The Molecular Signature of High-intensity Training in the Human Body
    Patrick Wahl, Wilhelm Bloch, Sebastian Proschinger
    International Journal of Sports Medicine.2022; 43(03): 195.     CrossRef
  • Recent development and advances in the fabrication and biomedical applications of nanoparticle-based drug delivery systems for metformin
    Xiaowei Yang, Qi Lai, Xinmin Yang, Banglin Xie, Bin Zhang, Xiaoyong Zhang, Yen Wei
    Materials Chemistry Frontiers.2022; 6(2): 128.     CrossRef
  • Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease
    Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisic
    International Journal of Molecular Sciences.2022; 23(1): 548.     CrossRef
  • The Effect of Various Training on the Expression of the 5’amp-Activated Protein Kinase Α2 and Glucose Transporter - 4 in Type-2 Diabetes Mellitus Rat
    Rahmi Rahmi, Yetty Machrina, Zulham Yamamoto
    Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 1.     CrossRef
  • Avian Orexin: Feed Intake Regulator or Something Else?
    Alison Ramser, Sami Dridi
    Veterinary Sciences.2022; 9(3): 112.     CrossRef
  • Luteolin Synergistically Enhances Antitumor Activity of Oxaliplatin in Colorectal Carcinoma via AMPK Inhibition
    Chan Ho Jang, Nayoung Moon, Jinkyung Lee, Min Jeong Kwon, Jisun Oh, Jong-Sang Kim
    Antioxidants.2022; 11(4): 626.     CrossRef
  • Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity
    Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition
    Jinsoo Kim, Jinyoung Son, Dohee Ahn, Gibeom Nam, Xiaodi Zhao, Hyuna Park, Woojoo Jeong, Sang J. Chung
    International Journal of Molecular Sciences.2022; 23(7): 3927.     CrossRef
  • Effect of Long-Term Supplementation with Acetic Acid on the Skeletal Muscle of Aging Sprague Dawley Rats
    Hitomi Maruta, Reina Abe, Hiromi Yamashita
    International Journal of Molecular Sciences.2022; 23(9): 4691.     CrossRef
  • AMP activated kinase negatively regulates hepatic Fetuin-A via p38 MAPK-C/EBPβ/E3 Ubiquitin Ligase Signaling pathway
    Vishal Kothari, Jeganathan Ramesh Babu, Suresh T. Mathews, Regis Moreau
    PLOS ONE.2022; 17(5): e0266472.     CrossRef
  • Lariciresinol Displays Anti‐Diabetic Activity through Inhibition of α‐Glucosidase and Activation and Enhancement of Insulin Signaling
    Md Badrul Alam, Jeong‐Sic Ra, Ji‐Young Lim, Bo‐Rim Song, Ahsan Javed, Sang‐Han Lee
    Molecular Nutrition & Food Research.2022;[Epub]     CrossRef
  • Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome
    Tara McDonnell, Leanne Cussen, Marie McIlroy, Michael W. O’Reilly
    Therapeutic Advances in Endocrinology and Metabolism.2022; 13: 204201882211131.     CrossRef
  • Anti-diabetic and anti-hyperlipidemic effects of sea cucumber (Cucumaria frondosa) gonad hydrolysates in type II diabetic rats
    Tingting Wang, Lin Zheng, Shuguang Wang, Mouming Zhao, Xiaoling Liu
    Food Science and Human Wellness.2022; 11(6): 1614.     CrossRef
  • Hernandezine, a natural herbal alkaloid, ameliorates type 2 diabetes by activating AMPK in two mouse models
    Jing Bai, Shuai Zhang, Jinjing Cao, Hongbin Sun, Zhiguo Mang, Wei L. Shen, Hao Li
    Phytomedicine.2022; 105: 154366.     CrossRef
  • N-Octyl Caffeamide, a Caffeic Acid Amide Derivative, Prevents Progression of Diabetes and Hepatic Steatosis in High-Fat Diet Induced Obese Mice
    Miao-Yi Wu, Chia-Chu Liu, Su-Chu Lee, Yueh-Hsiung Kuo, Tusty-Jiuan Hsieh
    International Journal of Molecular Sciences.2022; 23(16): 8948.     CrossRef
  • The Potential Therapeutic Role of Metformin in Diabetic and Non-Diabetic Bone Impairment
    Wei Mu, Guoqiang Liang, Yue Feng, Yunyun Jiang, Falin Qu
    Pharmaceuticals.2022; 15(10): 1274.     CrossRef
  • Characteristics of the Protocols Used in Electrical Pulse Stimulation of Cultured Cells for Mimicking In Vivo Exercise: A Systematic Review, Meta-Analysis, and Meta-Regression
    Eleni Nintou, Eleni Karligiotou, Maria Vliora, Leonidas G. Ioannou, Andreas D. Flouris
    International Journal of Molecular Sciences.2022; 23(21): 13446.     CrossRef
  • Heliciopsides A−E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of Heliciopsis terminalis and Their Stimulation of Glucose Uptake
    Byeol Ryu, Eun-Jin Park, Thi-Phuong Doan, Hyo-Moon Cho, Jin-Pyo An, Thi-Linh-Giang Pham, Ha-Thanh-Tung Pham, Won-Keun Oh
    Pharmaceuticals.2022; 15(11): 1315.     CrossRef
  • Why are physical activity breaks more effective than a single session of isoenergetic exercise in reducing postprandial glucose? A systemic review and meta-analysis
    Hannah Gouldrup, Tongyu Ma
    Journal of Sports Sciences.2021; 39(2): 212.     CrossRef
  • TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation
    Hee-Seon Park, Ji-Won Song, Jin-Ho Park, Byung-Kwan Lim, Og-Sung Moon, Hwa-Young Son, Jae-Hyuk Lee, Bin Gao, Young-Suk Won, Hyo-Jung Kwon
    Autophagy.2021; 17(9): 2549.     CrossRef
  • Dissecting the molecular pathways involved in the effects of physical activity on breast cancers cells: A narrative review
    Francesca Maria Orlandella, Anna Elisa De Stefano, Paola Lucia Chiara Iervolino, Pasqualina Buono, Andrea Soricelli, Giuliana Salvatore
    Life Sciences.2021; 265: 118790.     CrossRef
  • In silico study to quantify the effect of exercise on surface GLUT4 translocation in diabetes management
    Darshna M. Joshi, Jignesh Patel, Hardik Bhatt
    Network Modeling Analysis in Health Informatics and Bioinformatics.2021;[Epub]     CrossRef
  • Rationale for the use of metformin and exercise to counteract statin‐associated side effects
    Jonida Haxhi, Paul D. Thompson
    International Journal of Clinical Practice.2021;[Epub]     CrossRef
  • Effects of long-term taurine supplementation on age-related changes in skeletal muscle function of Sprague–Dawley rats
    Yun Ma, Hitomi Maruta, Baojun Sun, Chengduo Wang, Chiaki Isono, Hiromi Yamashita
    Amino Acids.2021; 53(2): 159.     CrossRef
  • The Effect of Swimming Training and Cinnamon Consumption on the Gene Expression of GLUT4 and Insulin Receptor in the Brown Adipose Tissue of Diabetic Rats
    Mojtaba Karimi Fard, Ali Khajehlandi, Amin Mohammadi
    Gene, Cell and Tissue.2021;[Epub]     CrossRef
  • Antiobesity effect of Brassica juncea cultivated in Jeongseon with optimized sinigrin content using 3T3‐L1 adipocytes
    Hee‐Yeon Kwon, Sun‐Il Choi, Xionggao Han, Xiao Men, Gill‐Woong Jang, Ye‐Eun Choi, Ok‐Hwan Lee
    Journal of Food Biochemistry.2021;[Epub]     CrossRef
  • Physicochemical characterization and the hypoglycemia effects of polysaccharide isolated from Passiflora edulis Sims peel
    Yuan Guan, Hefei Sun, Huiying Chen, Peijun Li, Yang Shan, Xia Li
    Food & Function.2021; 12(9): 4221.     CrossRef
  • Sirtuin 1 is not required for contraction-stimulated glucose uptake in mouse skeletal muscle
    Ji H. Kang, Ji E. Park, Jason Dagoon, Stewart W. C. Masson, Troy L. Merry, Shannon N. Bremner, Jessica R. Dent, Simon Schenk
    Journal of Applied Physiology.2021; 130(6): 1893.     CrossRef
  • TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells
    Parisa Vahidi Ferdowsi, Kiran D. K. Ahuja, Jeffrey M. Beckett, Stephen Myers
    Cells.2021; 10(6): 1560.     CrossRef
  • Effects of exercise on cellular and tissue aging
    Priscila Viana Carapeto, Cristina Aguayo-Mazzucato
    Aging.2021; 13(10): 14522.     CrossRef
  • Biglycan reduces body weight by regulating food intake in mice and improves glucose metabolism through AMPK/AKT dual pathways in skeletal muscle
    InHyeok Chung, Shin Ae Kim, Seolsong Kim, Jung Ok Lee, Clara Yongjoo Park, Juhee Lee, Jun Kang, Jin Young Lee, Ilhyeok Seo, Hye Jeong Lee, Jeong Ah Han, Min Ju Kang, Eunice Lim, Su Jin Kim, Sang Woo Wu, Joo Yeon Oh, Ji Hyung Chung, Eun‐Kyoung Kim, Hyeon S
    The FASEB Journal.2021;[Epub]     CrossRef
  • A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
    Ibrahim Mohammed, Morley D. Hollenberg, Hong Ding, Chris R. Triggle
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever
    Fred J. DiMenna, Avigdor D. Arad
    Cardiovascular Endocrinology & Metabolism.2021; 10(3): 149.     CrossRef
  • Comparative analyses of liver transcriptomes reveal the effect of exercise on growth-, glucose metabolism-, and oxygen transport-related genes and signaling pathways in grass carp (Ctenopharyngodon idella)
    Lang Zhang, Xiaohui Li, Yali Yu, Lin Zhang, Lixue Dong, Jinhua Gan, Tao Mao, Ting Liu, Jie Peng, Li He
    Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology.2021; 262: 111081.     CrossRef
  • Effects of moderate exercise on hepatic amino acid and fatty acid composition, liver transcriptome, and intestinal microbiota in channel catfish (Ictalurus punctatus)
    Lang Zhang, Yali Yu, Lixue Dong, Jinhua Gan, Tao Mao, Ting Liu, Xiaohui Li, Li He
    Comparative Biochemistry and Physiology Part D: Genomics and Proteomics.2021; 40: 100921.     CrossRef
  • Mangosteen xanthone γ-mangostin exerts lowering blood glucose effect with potentiating insulin sensitivity through the mediation of AMPK/PPARγ
    Sih-Pei Chen, Shian-Ren Lin, Ting-Hsu Chen, Hui-Suan Ng, Hip-Seng Yim, Max K. Leong, Ching-Feng Weng
    Biomedicine & Pharmacotherapy.2021; 144: 112333.     CrossRef
  • The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells
    Lakshi A. Dayarathne, Sachithra S. Ranaweera, Premkumar Natraj, Priyanka Rajan, Young Jae Lee, Chang-Hoon Han
    Journal of Veterinary Science.2021;[Epub]     CrossRef
  • Inhibition of Digestive Enzyme and Stimulation of Human Liver Cells (HepG2) Glucose Uptake by Date Seeds Extract
    Hira Shakoor, Fatima Abdelfattah, Khaula Albadi, Mentalla Adib, Jaleel Kizhakkayil, Carine Platat
    Evidence-Based Complementary and Alternative Medicine.2020; 2020: 1.     CrossRef
  • Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin
    Saman Bahrambeigi, Vahid Shafiei-Irannejad
    Biochemical Pharmacology.2020; 174: 113787.     CrossRef
  • Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle
    Sung Sup Park, Young-Kyo Seo
    International Journal of Molecular Sciences.2020; 21(6): 1949.     CrossRef
  • Regulation of podocytes function by AMP-activated protein kinase
    Dorota Rogacka, Irena Audzeyenka, Agnieszka Piwkowska
    Archives of Biochemistry and Biophysics.2020; 692: 108541.     CrossRef
  • AMPK'nin Biyokimyası: Etki Mekanizmaları ve Diyabetin Tedavisindeki Önemi
    Cemalettin KİSMİROĞLU, Serdar CENGİZ, Mustafa YAMAN
    European Journal of Science and Technology.2020; : 162.     CrossRef
  • Potent Inhibitory Effect of BJ-3105, a 6-Alkoxypyridin-3-ol Derivative, on Murine Colitis Is Mediated by Activating AMPK and Inhibiting NOX
    Pallavi Gurung, Sadan Dahal, Prakash Chaudhary, Diwakar Guragain, Ujjwala Karmacharya, Jung-Ae Kim, Byeong-Seon Jeong
    International Journal of Molecular Sciences.2020; 21(9): 3145.     CrossRef
  • Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in skeletal muscle
    Wai-Kin So, Hyoung Kyu Kim, Yingxian Chen, Seung Hun Jeong, Patrick Ka Kit Yeung, Billy C. K. Chow, Jin Han, Sookja K. Chung
    Pflügers Archiv - European Journal of Physiology.2020; 472(2): 195.     CrossRef
  • Metformin ameliorates animal models of dermatitis
    Soo Young Choi, Chanmi Lee, Min-Jeong Heo, Yeong Min Choi, In-sook An, Seunghee Bae, Sungkwan An, Jin Hyuk Jung
    Inflammopharmacology.2020; 28(5): 1293.     CrossRef
  • Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators
    Junwei Wang, Junhua Liu, Zhifu Xie, Jia Li, Jingya Li, Lihong Hu
    Bioorganic & Medicinal Chemistry Letters.2020; 30(2): 126790.     CrossRef
  • The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2
    Jung Ok Lee, Won Seok Byun, Min Ju Kang, Jeong Ah Han, Jiyoung Moon, Min‐Jeong Shin, Ho Jun Lee, Ji Hyung Chung, Jin‐Seok Lee, Chang‐Gue Son, Kwon‐Ho Song, Tae Woo Kim, Eun‐Soo Lee, Hong Min Kim, Choon Hee Chung, Kevin R. W. Ngoei, Naomi X. Y. Ling, Jonat
    The FEBS Journal.2020; 287(10): 2087.     CrossRef
  • Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes
    Khanyisani Ziqubu, Christo J. F. Muller, Phiwayinkosi V. Dludla, Sinenhlanhla X. H. Mthembu, Nnini Obonye, Johan Louw, Abidemi P. Kappo, Sonia Silvestri, Patrick Orlando, Luca Tiano, Sithandiwe E. Mazibuko-Mbeje
    Molecules.2020; 25(8): 1773.     CrossRef
  • Mitochondrial dysfunction regulates the JAK–STAT pathway via LKB1-mediated AMPK activation ER-stress-independent manner
    Dong-Yeon Kim, Su-Geun Lim, Kyoungho Suk, Won-Ha Lee
    Biochemistry and Cell Biology.2020; 98(2): 137.     CrossRef
  • cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells
    Toshio Norikura, Shiori Kajiya, Mami Sugawara, Miwa Kubo, Yoshiyasu Fukuyama, Shin Sato
    Journal of Functional Foods.2020; 64: 103632.     CrossRef
  • Delayed Exercise Training Improves Obesity-Induced Chronic Kidney Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice
    Florian Juszczak, Maud Vlassembrouck, Olivia Botton, Thomas Zwakhals, Morgane Decarnoncle, Alexandra Tassin, Nathalie Caron, Anne-Emilie Declèves
    International Journal of Molecular Sciences.2020; 22(1): 350.     CrossRef
  • The Regulation of Fat Metabolism during Aerobic Exercise
    Antonella Muscella, Erika Stefàno, Paola Lunetti, Loredana Capobianco, Santo Marsigliante
    Biomolecules.2020; 10(12): 1699.     CrossRef
  • Chronic neuromuscular electrical stimulation improves muscle mass and insulin sensitivity in a mouse model
    Adiel Lotri-Koffi, Marion Pauly, Emeline Lemarié, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pépin, Isabelle Vivodtzev
    Scientific Reports.2019;[Epub]     CrossRef
  • Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer
    Kyuwan Lee, Debu Tripathy, Wendy Demark-Wahnefried, Kerry S. Courneya, Nathalie Sami, Leslie Bernstein, Darcy Spicer, Thomas A. Buchanan, Joanne E. Mortimer, Christina M. Dieli-Conwright
    JAMA Oncology.2019; 5(5): 710.     CrossRef
  • Semen Cuscutae Administration Improves Hepatic Lipid Metabolism and Adiposity in High Fat Diet-Induced Obese Mice
    Jiyoung Moon, Min Jin Ha, Min-Jeong Shin, Oh Yoen Kim, Eun Hye Yoo, Juhyun Song, Ji Hyung Chung
    Nutrients.2019; 11(12): 3035.     CrossRef
  • Anthraquinone-type inhibitor of α-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes
    Md Badrul Alam, Vivek K. Bajpai, Jeong-Sic Ra, Ji-Young Lim, Hongyan An, Shruti Shukla, Khong Trong Quan, Imran Khan, Yun Suk Huh, Young-Kyu Han, MinKyun Na, Sang-Han Lee
    Food and Chemical Toxicology.2019; 129: 337.     CrossRef
  • AMPKα2 Deficiency Does Not Affect the Exercise-Induced Improvements in Glucose Tolerance and Metabolic Disorders in Mice Fed a High-Fat Diet
    Zhong-Guang SUN, Ge TIAN, Xiao-Ci ZHENG, Wen-Ying LIU, Xue-Ting LUO, Jing XIAO, Hui SONG, Xin XU
    Journal of Nutritional Science and Vitaminology.2019; 65(6): 491.     CrossRef
  • Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals
    Sanghee Park, Kristen D. Turner, Donghai Zheng, Jeffrey J. Brault, Kai Zou, Alec B. Chaves, Thomas S. Nielsen, Charles J. Tanner, Jonas T. Treebak, Joseph A. Houmard
    The Journal of Physiology.2019; 597(2): 449.     CrossRef
  • Mechanisms Involved in Glycemic Control Promoted by Exercise in Diabetics
    Eric Francelino Andrade, Víviam de Oliveira Silva, Débora Ribeiro Orlando, Luciano José Pereira
    Current Diabetes Reviews.2019; 15(2): 105.     CrossRef
  • Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway
    Nami Kim, Mi Sun Kang, Miso Nam, Shin Ae Kim, Geum-Sook Hwang, Hyeon Soo Kim
    International Journal of Molecular Sciences.2019; 20(19): 4751.     CrossRef
  • Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats
    Jeong Rim Ko, Dae Yun Seo, Tae Nyun Kim, Se Hwan Park, Hyo-Bum Kwak, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
    Journal of Clinical Medicine.2019; 8(5): 666.     CrossRef
  • Metformin; an old antidiabetic drug with new potentials in bone disorders
    Saman Bahrambeigi, Bahman Yousefi, Mahdi Rahimi, Vahid Shafiei-Irannejad
    Biomedicine & Pharmacotherapy.2019; 109: 1593.     CrossRef
  • A comparative analysis of various flavonoids in the regulation of obesity and diabetes: An in vitro and in vivo study
    Ritu Varshney, Rutusmita Mishra, Neeladrisingha Das, Debabrata Sircar, Partha Roy
    Journal of Functional Foods.2019; 59: 194.     CrossRef
  • Akt activation: A potential strategy to ameliorate insulin resistance
    Zhengyi Zhang, Huadong Liu, Jiankang Liu
    Diabetes Research and Clinical Practice.2019; 156: 107092.     CrossRef
  • Chitosan encapsulated nanocurcumin induces GLUT-4 translocation and exhibits enhanced anti-hyperglycemic function
    Pratibha Chauhan, Akhilesh Kumar Tamrakar, Sunil Mahajan, G.B.K.S. Prasad
    Life Sciences.2018; 213: 226.     CrossRef
  • Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity
    Victor Castro, Marta Skowronska, Jorge Lombardi, Jane He, Neil Seth, Martina Velichkovska, Michal Toborek
    Journal of Cerebral Blood Flow & Metabolism.2018; 38(2): 317.     CrossRef
  • Interactions between dietary carbohydrate and metformin: Implications on energy sensing, insulin signaling pathway, glycolipid metabolism and glucose tolerance in blunt snout bream Megalobrama amblycephala
    Chao Xu, Wen-Bin Liu, Ding-Dong Zhang, Xiu-Fei Cao, Hua-Juan Shi, Xiang-Fei Li
    Aquaculture.2018; 483: 183.     CrossRef
  • Gossypol from Cottonseeds Ameliorates Glucose Uptake by Mimicking Insulin Signaling and Improves Glucose Homeostasis in Mice with Streptozotocin-Induced Diabetes
    Md Badrul Alam, Hongyan An, Jeong-Sic Ra, Ji-young Lim, Seung-Hyun Lee, Chi-Yeol Yoo, Sang-Han Lee
    Oxidative Medicine and Cellular Longevity.2018; 2018: 1.     CrossRef
  • PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
    Pär Steneberg, Emma Lindahl, Ulf Dahl, Emmelie Lidh, Jurate Straseviciene, Fredrik Backlund, Elisabet Kjellkvist, Eva Berggren, Ingela Lundberg, Ingela Bergqvist, Madelene Ericsson, Björn Eriksson, Kajsa Linde, Jacob Westman, Thomas Edlund, Helena Edlund
    JCI Insight.2018;[Epub]     CrossRef
  • Aerobic exercise training decreases cereblon and increases AMPK signaling in the skeletal muscle of STZ-induced diabetic rats
    Jeong Rim Ko, Dae Yun Seo, Se Hwan Park, Hyo Bum Kwak, Min Kim, Kyung Soo Ko, Byoung Doo Rhee, Jin Han
    Biochemical and Biophysical Research Communications.2018; 501(2): 448.     CrossRef
  • AMPK in skeletal muscle function and metabolism
    Rasmus Kjøbsted, Janne R. Hingst, Joachim Fentz, Marc Foretz, Maria‐Nieves Sanz, Christian Pehmøller, Michael Shum, André Marette, Remi Mounier, Jonas T. Treebak, Jørgen F. P. Wojtaszewski, Benoit Viollet, Louise Lantier
    The FASEB Journal.2018; 32(4): 1741.     CrossRef
  • Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins
    Tianyi Wang, Yanmei Niu, Sujuan Liu, Hairui Yuan, Xiaolei Liu, Li Fu
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(10): 3368.     CrossRef
  • Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury
    Peng Wang, Lizhu Jiang, Nian Zhou, Hao Zhou, Huzhe Liu, Wenrui Zhao, Hanxiang Zhang, Xiang Zhang, Zhenming Hu
    Oncotarget.2018; 9(9): 8427.     CrossRef
  • Cocoa Flavanol Supplementation and Exercise: A Systematic Review
    Lieselot Decroix, Danusa Dias Soares, Romain Meeusen, Elsa Heyman, Cajsa Tonoli
    Sports Medicine.2018; 48(4): 867.     CrossRef
  • Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes
    Hojun Lee, Wook Song
    Journal of Obesity & Metabolic Syndrome.2018; 27(3): 150.     CrossRef
  • Vernonia cinerea water extract improves insulin resistance in high-fat diet–induced obese mice
    Jarinyaporn Naowaboot, Supaporn Wannasiri, Patchareewan Pannangpetch
    Nutrition Research.2018; 56: 51.     CrossRef
  • Cell-Specific “Competition for Calories” Drives Asymmetric Nutrient-Energy Partitioning, Obesity, and Metabolic Diseases in Human and Non-human Animals
    Edward Archer, Gregory Pavela, Samantha McDonald, Carl J. Lavie, James O. Hill
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
    Baile Wang, Kenneth Cheng
    International Journal of Molecular Sciences.2018; 19(11): 3552.     CrossRef
  • Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
    Danqing Feng, Tesfaye Biftu, F. Anthony Romero, Ahmet Kekec, James Dropinski, Andrew Kassick, Shiyao Xu, Marc M. Kurtz, Anantha Gollapudi, Qing Shao, Xiaodong Yang, Ku Lu, Gaochao Zhou, Daniel Kemp, Robert W. Myers, Hong-Ping Guan, Maria E. Trujillo, Cai
    ACS Medicinal Chemistry Letters.2018; 9(1): 39.     CrossRef
  • 2-Bromo-4′-methoxychalcone and 2-Iodo-4′-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5′-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice
    Chi-Ting Hsieh, Fang-Rong Chang, Yi-Hong Tsai, Yang-Chang Wu, Tusty-Jiuan Hsieh
    International Journal of Molecular Sciences.2018; 19(9): 2763.     CrossRef
  • Dynamic transcriptomic analysis in hircine longissimus dorsi muscle from fetal to neonatal development stages
    Siyuan Zhan, Wei Zhao, Tianzeng Song, Yao Dong, Jiazhong Guo, Jiaxue Cao, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang
    Functional & Integrative Genomics.2018; 18(1): 43.     CrossRef
  • Oyster mushroom functions as an anti-hyperglycaemic through phosphorylation of AMPK and increased expression of GLUT4 in type 2 diabetic model rats
    Mohammad Asrafuzzaman, Mohammad M. Rahman, Manoj Mandal, Mohammad Marjuque, Amrita Bhowmik, Begum Rokeya, Zahid Hassan, Mohammad Omar Faruque
    Journal of Taibah University Medical Sciences.2018; 13(5): 465.     CrossRef
  • AMP-activated protein kinase α1 in Megalobrama amblycephala: Molecular characterization and the transcriptional modulation by nutrient restriction and glucose and insulin loadings
    Chao Xu, Xiang-Fei Li, Hua-Juan Shi, Jie Liu, Li Zhang, Wen-Bin Liu
    General and Comparative Endocrinology.2018; 267: 66.     CrossRef
  • Comprehensive Relevance of AMPK in Adaptive Responses of Physical Exercise, Skeletal Muscle and Neuromuscular Disorders
    Jun-Ho Lee
    Journal of The Korean Society of Physical Medicine.2018; 13(3): 141.     CrossRef
  • Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism
    Natalie Janzen, Jamie Whitfield, Nolan Hoffman
    International Journal of Molecular Sciences.2018; 19(11): 3344.     CrossRef
  • Exercising with blocked muscle glycogenolysis: Adaptation in the McArdle mouse
    Tue L. Nielsen, Tomàs Pinós, Astrid Brull, John Vissing, Thomas O. Krag
    Molecular Genetics and Metabolism.2018; 123(1): 21.     CrossRef
  • Pharmacological Activities of Mogrosides
    Can Liu, Longhai Dai, Yueping Liu, Dequan Dou, Yuanxia Sun, Lanqing Ma
    Future Medicinal Chemistry.2018; 10(8): 845.     CrossRef
  • Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4
    Kevin R.W. Ngoei, Christopher G. Langendorf, Naomi X.Y. Ling, Ashfaqul Hoque, Swapna Varghese, Michelle A. Camerino, Scott R. Walker, Ylva E. Bozikis, Toby A. Dite, Ashley J. Ovens, William J. Smiles, Roxane Jacobs, He Huang, Michael W. Parker, John W. Sc
    Cell Chemical Biology.2018; 25(6): 728.     CrossRef
  • Fiber type-specific analysis of AMPK isoforms in human skeletal muscle: advancement in methods via capillary nanoimmunoassay
    Irene S. Tobias, Kara K. Lazauskas, Jose A. Arevalo, James R. Bagley, Lee E. Brown, Andrew J. Galpin
    Journal of Applied Physiology.2018; 124(4): 840.     CrossRef
  • Insulin Mimetic Activity of 3,4-Seco and Hexanordammarane Triterpenoids Isolated from Gynostemma longipes
    Ha Thanh Tung Pham, Thi Kim Quy Ha, Hyo Moon Cho, Ba Wool Lee, Jin Pyo An, Van On Tran, Won Keun Oh
    Journal of Natural Products.2018; 81(11): 2470.     CrossRef
  • Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism
    A.D. Booth, A.M. Magnuson, J. Fouts, Y. Wei, D. Wang, M.J. Pagliassotti, M.T. Foster
    Adipocyte.2018; 7(4): 261.     CrossRef
  • Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase
    Kasandra S. Hunter, Stephen J. Davies
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • Neurogenic obesity and systemic inflammation following spinal cord injury: A review
    Gary J. Farkas, David R. Gater
    The Journal of Spinal Cord Medicine.2018; 41(4): 378.     CrossRef
  • In Defense of Sugar: A Critique of Diet-Centrism
    Edward Archer
    Progress in Cardiovascular Diseases.2018; 61(1): 10.     CrossRef
  • Anti-inflammatory effects induced by pharmaceutical substances on inflammatory active brain astrocytes—promising treatment of neuroinflammation
    Elisabeth Hansson, Ulrika Björklund, Eva Skiöldebrand, Lars Rönnbäck
    Journal of Neuroinflammation.2018;[Epub]     CrossRef
  • Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin‐Induced Diabetic Mice
    Joo‐Hui Han, Nguyen Quoc Tuan, Min‐Ho Park, Khong Trong Quan, Joonseok Oh, Kyung‐Sun Heo, MinKyun Na, Chang‐Seon Myung
    Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
  • Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
    Robert W. Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, Effie Tozzo, Xiaodong Yang, Marc M. Kurtz, Maria Trujillo, Dinko Gonzalez Trotter, Danqing Feng, Shiyao Xu, George Eiermann, Marie A. Holahan, Daniel Rubins, Stacey C
    Science.2017; 357(6350): 507.     CrossRef
  • Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: A portrait of molecular crosstalk
    Mohammad Adil, Mohd Nizam Mansoori, Divya Singh, Amit Dattatraya Kandhare, Manju Sharma
    Biomedicine & Pharmacotherapy.2017; 94: 1010.     CrossRef
  • Rb2 inhibits α-glucosidase and regulates glucose metabolism by activating AMPK pathways in HepG2 cells
    Hui Teng, Lei Chen, Ting Fang, Benyao Yuan, Qiyang Lin
    Journal of Functional Foods.2017; 28: 306.     CrossRef
  • The Emerging Role of Thioredoxin-Interacting Protein in Myocardial Ischemia/Reperfusion Injury
    Bing F. Wang, Jun Yoshioka
    Journal of Cardiovascular Pharmacology and Therapeutics.2017; 22(3): 219.     CrossRef
  • Efectos del ejercicio físico en los factores de riesgo cardiovascular que constituyen el síndrome metabólico: una alternativa para reducir su tendencia
    Adrián Hernández Alonso
    Revista Colombiana de Médicina Física y Rehabilitación.2017; 27(2): 140.     CrossRef
  • Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells
    Nami Kim, Miso Nam, Mi Sun Kang, Jung Ok Lee, Yong Woo Lee, Geum-Sook Hwang, Hyeon Soo Kim
    Scientific Reports.2017;[Epub]     CrossRef
  • Vitamin D supplementation inhibits oxidative stress and upregulate SIRT1/AMPK/GLUT4 cascade in high glucose-treated 3T3L1 adipocytes and in adipose tissue of high fat diet-fed diabetic mice
    Prasenjit Manna, Arunkumar E. Achari, Sushil K. Jain
    Archives of Biochemistry and Biophysics.2017; 615: 22.     CrossRef
  • Care of the Athlete With Type 1 Diabetes Mellitus: A Clinical Review
    William B. Horton, Jose S. Subauste
    International Journal of Endocrinology and Metabolism.2016;[Epub]     CrossRef
  • Cheonggukjang, a soybean paste fermented with B. licheniformis-67 prevents weight gain and improves glycemic control in high fat diet induced obese mice
    Joo-Hee Choi, P.B.Tirupathi Pichiah, Min-Jung Kim, Youn-Soo Cha
    Journal of Clinical Biochemistry and Nutrition.2016; 59(1): 31.     CrossRef
  • Rg3 Improves Mitochondrial Function and the Expression of Key Genes Involved in Mitochondrial Biogenesis in C2C12 Myotubes
    Min Joo Kim, Young Do Koo, Min Kim, Soo Lim, Young Joo Park, Sung Soo Chung, Hak C. Jang, Kyong Soo Park
    Diabetes & Metabolism Journal.2016; 40(5): 406.     CrossRef
  • Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss
    H.P. Vasantha Rupasinghe, Satvir Sekhon-Loodu, Theodora Mantso, Mihalis I. Panayiotidis
    Pharmacology & Therapeutics.2016; 165: 153.     CrossRef
  • Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise
    Haiyan Wang, Naveen Sharma, Edward B. Arias, Gregory D. Cartee
    The Journals of Gerontology Series A: Biological Sciences and Medical Sciences.2016; 71(3): 323.     CrossRef
  • Acute resistance exercise-induced IGF1 expression and subsequent GLUT4 translocation
    Kohei Kido, Satoru Ato, Takumi Yokokawa, Yuhei Makanae, Koji Sato, Satoshi Fujita
    Physiological Reports.2016; 4(16): e12907.     CrossRef
  • Regulation and function of AMPK in physiology and diseases
    Sang-Min Jeon
    Experimental & Molecular Medicine.2016; 48(7): e245.     CrossRef
  • Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
    Junjeong Choi, Ji-Hyun Lee, Ilkyoo Koh, Jin-Kyoung Shim, Junseong Park, Jeong Yong Jeon, Mijin Yun, Se Hoon Kim, Jong In Yook, Eui Hyun Kim, Jong Hee Chang, Sun Ho Kim, Yong Min Huh, Su Jae Lee, Michael Pollak, Pilnam Kim, Seok-Gu Kang, Jae-Ho Cheong
    Oncotarget.2016; 7(40): 65643.     CrossRef
  • [6]‐Gingerol Affects Glucose Metabolism by Dual Regulation via the AMPKα2‐Mediated AS160–Rab5 Pathway and AMPK‐Mediated Insulin Sensitizing Effects
    Jung Ok Lee, Nami Kim, Hye Jeong Lee, Ji Wook Moon, Soo Kyung Lee, Su Jin Kim, Joong Kwan Kim, Sun Hwa Park, Hyeon Soo Kim
    Journal of Cellular Biochemistry.2015; 116(7): 1401.     CrossRef
  • A glance at … exercise and glucose uptake
    Michael J. Glade, Kyl Smith
    Nutrition.2015; 31(6): 893.     CrossRef
  • Exercising insulin sensitivity: AMPK turns on autophagy!
    Yossi Dagon, Christos Mantzoros, Young-Bum Kim
    Metabolism.2015; 64(6): 655.     CrossRef
  • Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice
    José M. Costa Júnior, Morgana R. Rosa, André O. Protzek, Flávia M. de Paula, Sandra M. Ferreira, Luiz F. Rezende, Emerielle C. Vanzela, Cláudio C. Zoppi, Leonardo R. Silveira, Isis C. Kettelhut, Antonio C. Boschero, Camila A. M. de Oliveira, Everardo M. C
    Amino Acids.2015; 47(4): 745.     CrossRef
  • Endoplasmic reticulum chaperone GRP78 is involved in autophagy activation induced by ischemic preconditioning in neural cells
    Xiang-Yang Zhang, Tong-Tong Zhang, Dan-Dan Song, Jun- Hao Zhou, Rong Han, Zheng-Hong Qin, Rui Sheng
    Molecular Brain.2015;[Epub]     CrossRef
  • Identification of adenine modulating AMPK activation in NIH/3T3 cells by proteomic approach
    Guang-Huar Young, Jiun-Tsai Lin, Yi-Fang Cheng, Chun-Fang Huang, Cheng-Yu Chao, Jing-Yi Nong, Po-Ku Chen, Han-Min Chen
    Journal of Proteomics.2015; 120: 204.     CrossRef
  • Mechanisms for independent and combined effects of calorie restriction and acute exercise on insulin-stimulated glucose uptake by skeletal muscle of old rats
    Naveen Sharma, Haiyan Wang, Edward B. Arias, Carlos M. Castorena, Gregory D. Cartee
    American Journal of Physiology-Endocrinology and Metabolism.2015; 308(7): E603.     CrossRef
  • Human muscle fibre type‐specific regulation of AMPK and downstream targets by exercise
    Dorte E. Kristensen, Peter H. Albers, Clara Prats, Otto Baba, Jesper B. Birk, Jørgen F. P. Wojtaszewski
    The Journal of Physiology.2015; 593(8): 2053.     CrossRef
  • Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK
    Qun Huang, Lei Chen, Hui Teng, Hongbo Song, Xiaoqi Wu, Meiyu Xu
    Journal of Functional Foods.2015; 19: 487.     CrossRef
  • Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells
    Mohamad Abu Bakar, Kian-Kai Cheng, Mohamad Sarmidi, Harisun Yaakob, Hasniza Huri
    Molecules.2015; 20(5): 8242.     CrossRef
  • Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance
    Mark J. W. Hanssen, Roel Wierts, Joris Hoeks, Anne Gemmink, Boudewijn Brans, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
    Diabetologia.2015; 58(3): 586.     CrossRef
  • Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise
    Hayley M. O'Neill, James S. Lally, Sandra Galic, Thomas Pulinilkunnil, Rebecca J. Ford, Jason R. B. Dyck, Bryce J. van Denderen, Bruce E. Kemp, Gregory R. Steinberg
    Physiological Reports.2015; 3(7): e12444.     CrossRef
  • Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation
    Sukriti Krishan, Des R. Richardson, Sumit Sahni
    Molecular Pharmacology.2015; 87(3): 363.     CrossRef
  • Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle
    Takashi Sasaki, Rieko Nakata, Hiroyasu Inoue, Makoto Shimizu, Jun Inoue, Ryuichiro Sato
    American Journal of Physiology-Endocrinology and Metabolism.2014; 306(9): E1085.     CrossRef
  • A novel heterozygous mutation in the glucokinase gene conferring exercise-induced symptomatic hyperglycaemia responsive to sulfonylurea
    M.S.E. Ebrahim, M.L. Lawson, M.T. Geraghty
    Diabetes & Metabolism.2014; 40(4): 310.     CrossRef
  • Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice
    Kwon-Il Seo, Jin Lee, Ra-Yeong Choi, Hae-In Lee, Ju-Hye Lee, Yong-Ki Jeong, Myung-Joo Kim, Mi-Kyung Lee
    Food & Function.2014; 5(7): 1579.     CrossRef
  • The AMPK-SIRT signaling network regulates glucose tolerance under calorie restriction conditions
    M.F.P. Silvestre, B. Viollet, P.W. Caton, J. Leclerc, I. Sakakibara, M. Foretz, M.C. Holness, M.C. Sugden
    Life Sciences.2014; 100(1): 55.     CrossRef
  • Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation
    Fan-Lun Liu, Jui-Ling Hsu, Yean-Jang Lee, Yu-Shun Dong, Fan-Lu Kung, Ching-Shih Chen, Jih-Hwa Guh
    European Journal of Pharmacology.2014; 730: 90.     CrossRef
  • Fighting obesity: When muscle meets fat
    Xin Yang, Pengpeng Bi, Shihuan Kuang
    Adipocyte.2014; 3(4): 280.     CrossRef
  • Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway
    Bo-Lin Chen, Li-Ting Wang, Kuo-How Huang, Ching-Chia Wang, Chih-Kang Chiang, Shing-Hwa Liu
    The Journal of Nutritional Biochemistry.2014; 25(11): 1226.     CrossRef
  • AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
    Louise Lantier, Joachim Fentz, Rémi Mounier, Jocelyne Leclerc, Jonas T. Treebak, Christian Pehmøller, Nieves Sanz, Iori Sakakibara, Emmanuelle Saint‐Amand, Stéphanie Rimbaud, Pascal Maire, André Marette, Renée Ventura‐Clapier, Arnaud Ferry, Jørgen F. P. W
    The FASEB Journal.2014; 28(7): 3211.     CrossRef
  • Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity
    Mario Ost, Franziska Werner, Janine Dokas, Susanne Klaus, Anja Voigt, Juergen Eckel
    PLoS ONE.2014; 9(4): e94689.     CrossRef
  • Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
    Min-Jung Park, Dong-Il Kim, Seul-Ki Lim, Joo-Hee Choi, Jong-Choon Kim, Kyung-Chul Yoon, Jee-Bum Lee, Jae-Hyuk Lee, Ho-Jae Han, In-Pyo Choi, Hyoung-Chin Kim, Soo-Hyun Park
    Journal of Hepatology.2014; 61(5): 1151.     CrossRef
  • Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells
    Zhu Li, Chang-Lin Ni, Zhi Yao, Li-Ming Chen, Wen-Yan Niu
    Metabolism.2014; 63(8): 1022.     CrossRef
  • Effects of metformin on weight loss
    Steven K. Malin, Sangeeta R. Kashyap
    Current Opinion in Endocrinology, Diabetes & Obesity.2014; 21(5): 323.     CrossRef
  • Changes of Blood Glucose and Lactate Concentration in Body Wearing Firefighting Protective Equipments
    Chang-Hoon Bang
    Journal of Korean Society of Hazard Mitigation.2014; 14(1): 263.     CrossRef
  • Exercise, Energy Intake, Glucose Homeostasis, and the Brain
    Henriette van Praag, Monika Fleshner, Michael W. Schwartz, Mark P. Mattson
    The Journal of Neuroscience.2014; 34(46): 15139.     CrossRef
  • The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
    Takuya Sakurai, Junetsu Ogasawara, Takako Kizaki, Shogo Sato, Yoshinaga Ishibashi, Motoko Takahashi, Osamu Kobayashi, Shuji Oh-ishi, Junichi Nagasawa, Kazuto Takahashi, Hitoshi Ishida, Tetsuya Izawa, Hideki Ohno
    International Journal of Endocrinology.2013; 2013: 1.     CrossRef
  • Flavonoids from Tetrastigma obtectum enhancing glucose consumption in insulin-resistance HepG2 cells via activating AMPK
    Mei-Na Jin, Guo-Ru Shi, Sheng-An Tang, Nan-Qin, Wei Qiao, Hong-Quan Duan
    Fitoterapia.2013; 90: 240.     CrossRef
  • AMPK, insulin resistance, and the metabolic syndrome
    Neil B. Ruderman, David Carling, Marc Prentki, José M. Cacicedo
    Journal of Clinical Investigation.2013; 123(7): 2764.     CrossRef
  • Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming
    Veronica Martinez Marignac, Sarah Smith, Nader Toban, Miguel Bazile, Raquel Aloyz
    Oncotarget.2013; 4(12): 2550.     CrossRef
  • Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats
    Wenjuan Xing, Youyou Li, Haifeng Zhang, Chunjuan Mi, Zuoxu Hou, Michael J. Quon, Feng Gao
    American Journal of Physiology-Heart and Circulatory Physiology.2013; 305(8): H1111.     CrossRef
  • AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma
    Chin-Jung Hsu, Min-Huan Wu, Chin-Yuan Chen, Chun-Hao Tsai, Horng-Chaung Hsu, Chih-Hsin Tang
    Cell Communication and Signaling.2013;[Epub]     CrossRef
Original Articles
AICAR Reversed the Glucolipotoxicity Induced beta-cell Dysfunction through Suppression of PPAR-gamma-coactivator-1 (PGC-1) Overexpression.
Hyuk Sang Kwon, Ji Won Kim, Heon Seok Park, Seung Hyun Ko, Bong Yun Cha, Ho Young Son, Kun Ho Yoon
Korean Diabetes J. 2007;31(4):310-318.   Published online July 1, 2007
  • 2,050 View
  • 21 Download
AbstractAbstract PDF
Glucolipotoxicity plays an important role in the progression of type 2 diabetes mellitus via inducing insulin secretory dysfunction. Expression of insulin gene in pancreatic beta cell might be regulated by AMP-activated protein kinase (AMPK), which is recognized as a key molecule of energy metabolism. We studied the effects of AMPK on glucolipotoxicity-induced beta-cell dysfunction by suppression of PPAR-gamma-coactivator-1 (PGC-1) in vitro and in vivo. Method: Glucolipotoxicity was induced by 33.3 mM glucose and 0.6 mM (palmitate and oleate) for 3 days in isolated rat islets. Messenger RNA (mRNA) expressions of beta-cell specific gene like insulin, BETA2/NeuroD and PGC-1 induced by glucolipotoxic condition and their changes with 5-aminoimidazole-4-carboxy-amide-1-D-ribofuranoside (AICAR) treatment were investigated using RT-PCR. We also examined glucose stimulated insulin secretion in same conditions. Furthermore, SD rats were submitted to a 90% partial pancreatectomy (Px) and randomized into two groups; Ad-GFP-infected Px rats (n = 3) and Ad-siPGC- 1-infected Px rats (n = 3). Then, the Px rats were infected with Ad-GFP or Ad-siPGC-1 (1 x 10(9) pfu) via celiac artery. After 12 days of viral infection, we measured body weight and performed the intraperitoneal glucose tolerance test (IP-GTT). RESULTS: Glucolipotoxicity resulted in blunting of glucose-stimulated insulin secretion, which was recovered by the AICAR treatment in vitro. Suppression in their expressions of insulin and BETA2/NeuroD gene by glucolipotoxic condition were improved with AICAR treatment. However, PGC-1alpha expression was gradually increased by glucolipotoxicity, and suppressed by AICAR treatment. Overexpression of PGC-1 using an adenoviral vector in freshly isolated rat islets suppressed insulin gene expression. We also confirmed the function of PGC-1 using an Ad-siPGC-1 in vivo. Direct infection of Ad-siPGC-1 in 90% pancreatectomized rats significantly improved glucose tolerance and increased body weight. CONCLUSION: AMPK could protect against glucolipotoxicity induced beta-cell dysfunction and the suppression of PGC-1 gene expression might involved in the insulin regulatory mechanism by AMPK.
Increase in Fatty Acid Oxidation by AICAR: the Role of p38 MAPK.
Woo Je Lee, Jin Yob Kim, Sung Jin Bae, Eun Hee Koh, Sung Min Han, Hye Sun Park, Hyun Sik Kim, Min Seon Kim, Joong Yeol Park, Ki Up Lee
Korean Diabetes J. 2005;29(1):15-21.   Published online January 1, 2005
  • 1,110 View
  • 25 Download
AbstractAbstract PDF
AMPK is an enzyme that increases glucose transport and fatty acid oxidation in skeletal muscle. The activation of AMPK stimulates fatty acid oxidation by decreasing the acetyl CoA carboxylase (ACC) activity and the concentration of malonyl-CoA. However, a recent study has reported a dissociation of AMPK activity and ACC phosphorylation in skeletal muscle during periods of prolonged exercise. This suggested that there is an additional mechanism for AMPK-induced fatty acid oxidation in skeletal muscle. METHODS: Plamitate oxidation was measured via the generation of [3H]-water generation from 9,10[3H]-palmitate after treating various concentrations of AICAR on the C2C12 mouse skeletal muscle cell line. Western analysis was used to test for the possible activation of p38 MAPK by AICAR. Involvement of p38 MAPK in the AICAR-induced increase in fatty acid oxidation was tested for by using SB203580, a p38 MAPK inhibitor. RESULTS: C2C12 cell treated with AICAR exhibited a dose-dependent increase in fatty acid oxidation compared to the cells that were not treated with AICAR. Western blot analysis revealed that phosphorylation of p38 MAPK was increased 2.5 folds after AICAR treatment. The increase of fatty acid oxidation with AICAR treatment was significantly inhibited by a treatment of SB203580; this indicated the involvement of p38 MAPK on the AICAR-induced increase in fatty acid oxidation. CONCLUSION: AICAR stimulated the fatty acid oxidation by activating p38 MAPK. This is a novel pathway by which AMPK activation in skeletal muscle increases the fatty acid oxidation
AMPK Activator AICAR Inhibits Hepatic Gluconeogenesis and Fatty Acid Oxidation.
Jin Yob Kim, Eun Hee Koh, Woo Je Lee, Seong Min Han, Ji Young Youn, Hye Sun Park, Hyun Sik Kim, Min Seon Kim, Joong Yeol Park, Ki Up Lee
Korean Diabetes J. 2005;29(1):6-14.   Published online January 1, 2005
  • 1,268 View
  • 25 Download
AbstractAbstract PDF
Recent studies have demonstrated that adiponectin and metformin activate AMPK in the liver, and adiponectin and metformin stimulate fatty acid oxidation while inhibiting glucose production in liver. These results are in contrast to previous studies that have demonstrated that increased fatty acid oxidation in the liver is associated with increased gluconeogenesis. The present study was undertaken to reinvestigate the effects of AMPK activation by AICAR on hepatic fatty acid oxidation and gluconeogenesis. METHODS: HePG2 cells were treated with various concentrations of AICAR, and then the fatty acid oxidation and gluconeogenesis of the cells were determined. To investigate the in vivo effect of AICAR, Sprague-Dawely rats were infused with AICAR (bolus, 40 mg/g; constant, 7.5 mg/g/min-1) for 90min. RESULTS: Incubation of the HePG2 cells with higher concentrations (=1 mM) of AICAR increased fatty acid oxidation and gluconeogenesis. On the other hand, incubation of HePG2 cells with lower concentrations (0.05 and 0.1 mM) of AICAR decreased fatty acid oxidation and gluconeogenesis. Consistent with this in vitro data, the intravenous administration of AICAR to rats lowered their plasma glucose concentration and inhibited hepatic gluconeogenesis. Fatty acid oxidation in the liver tissue was significantly decreased by the administration of AICAR. CONCLUSION: The present study has demonstrated that AICAR decreased gluconeo-genesis in the liver. In contrast to previous studies, AICAR profoundly decreased hepatic fatty acid oxidation in rats and also in cultured hepatocytes
Hypothalamic AMPK Activity in Diabetic Rats.
Churl Namkoong, Min Seon Kim, Woo Je Lee, Pil Geum Jang, Seong Min Han, Eun Hee Koh, Joong Yeol Park, Ki Up Lee
Korean Diabetes J. 2004;28(6):468-477.   Published online December 1, 2004
  • 949 View
  • 18 Download
AbstractAbstract PDF
AMP-activated protein kinase (AMPK) acts as a cellular energy sensor that is activated during states of low energy charge and it regulates the various metabolic pathways to reestablish the normal cellular energy balance. It has recently been demonstrated that AMPK activity is altered by the state of energy metabolism in the hypothalamic neurons and this mediates the feeding response. METHODS: Diabetes was induced by an intra-peritoneal injection of streptozotocin (STZ) in Sprague-Dawley rats. The diabetic rats were maintained for 3 weeks with or without insulin treatment. 3 weeks later, we collected hypothalamus and we then assayed the phosphorylation of AMPK and the activity of acetyl CoA carboxylase (ACC) and isoform-specfic AMPK. To determine the effect of hypothalamic AMPK inhibition on diabetic hyperphagia, we administered an AMPK inhibitor, compound C, into the third ventricle in the STZ-induced diabetic rats. RESULTS: Phosphorylation of AMPK, which is a marker of AMPK activation, increased in the hypothalamus of the STZ-induced diabetic rats (DR). Moreover, 2-AMPK activity, but not 1-AMPK activity, increased by 2-fold in hypothalamus of the DRs. Phosphorylation of hypothalamic acetyl CoA carboxylase (ACC), a key downstream enzyme of AMPK, also increased in the DRs and this caused a reduction in ACC activity. Insulin treatment completely reversed the diabetesinduced changes in the hypothalamic AMPK and ACC, suggesting that insulin deficiency was associated with the changes in hypothalamic AMPK and ACC. Inhibition of AMPK by an intracerebroventricular administration of AMPK inhibitor, compound C, attenuated the development of diabetic hyperphagia and reduced the blood glucose levels in DRs. CONCLUSION: We have demonstrated that hypothalamic AMPK activity increased in the DRs, and inhibition of hypothalamic AMPK activity attenuated the development of diabetic hyperphagia. These data indicate that the enhanced hypothalamic AMPK activity may contribute to the development of diabetic hyperphagia

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer