Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
4 "Young Sil Eom"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Review
Others
Links between Thyroid Disorders and Glucose Homeostasis
Young Sil Eom, Jessica R. Wilson, Victor J. Bernet
Diabetes Metab J. 2022;46(2):239-256.   Published online March 24, 2022
DOI: https://doi.org/10.4093/dmj.2022.0013
  • 46,408 View
  • 1,285 Download
  • 93 Web of Science
  • 106 Crossref
AbstractAbstract PDFPubReader   ePub   
Thyroid disorders and diabetes mellitus often coexist and are closely related. Several studies have shown a higher prevalence of thyroid disorders in patients with diabetes mellitus and vice versa. Thyroid hormone affects glucose homeostasis by impacting pancreatic β-cell development and glucose metabolism through several organs such as the liver, gastrointestinal tract, pancreas, adipose tissue, skeletal muscles, and the central nervous system. The present review discusses the effect of thyroid hormone on glucose homeostasis. We also review the relationship between thyroid disease and diabetes mellitus: type 1, type 2, and gestational diabetes, as well as guidelines for screening thyroid function with each disorder. Finally, we provide an overview of the effects of antidiabetic drugs on thyroid hormone and thyroid disorders.

Citations

Citations to this article as recorded by  
  • Glucose metabolism in anterior pituitary adenomas
    Valeria Hernández-Brito, Stephanie Lemoni Casco-Morales, Andrés Vega-Rosas
    Clinica Chimica Acta.2026; 578: 120587.     CrossRef
  • Adverse Outcomes in Patients With Hypothyroidism Undergoing Bariatric Surgery: A Retrospective Study Using TriNetX
    Vandrize Meneghini, Fabyan Esberard de Lima Beltrão, George Golovko, Riley K Watson, Sarah Samreen, Matthew D Ettleson, Isabela M Benseñor, Antonio C Bianco
    The Journal of Clinical Endocrinology & Metabolism.2026; 111(3): e766.     CrossRef
  • Another pleiotropic effect of SGLT2 inhibitors: Is it a new frontier in thyroid function regulation?
    Michał Szklarz, Katarzyna Wołos-Kłosowicz, Joanna Szulc, Jan Górny, Robert Modzelewski, Wojciech Matuszewski
    Thyroid Research.2026;[Epub]     CrossRef
  • The public health burden of diabetes mellitus and thyroid disease: twin epidemics
    Salman Razvi
    Nature Reviews Endocrinology.2026; 22(4): 242.     CrossRef
  • Associations of perfluoroalkyl and polyfluoroalkyl substances with markers of glycaemic control, insulin secretion and sensitivity, and diabetes risk: a systematic review and meta-analyses
    Sandra India Aldana, Xin Yu, Meizhen Yao, Nathan Cohen, Eftychia Markopoulou, Maanal Chowdhury, Vishal Midya, Stephanie M. Eick, Jessica Trowbridge, Anne P. Starling, Dinesh Barupal, Douglas I. Walker, Leda Chatzi, Veronica Wendy Setiawan, Ryan W. Walker,
    eClinicalMedicine.2026; 92: 103747.     CrossRef
  • Severe hyperglycaemia associated with prolonged isoflurane anaesthesia in an alpaca (Vicugna pacos)
    Andrea Basler, Kathlyn Noelle Kuek, Friederike Pohlin, Ivana Calice
    Veterinary Record Case Reports.2026;[Epub]     CrossRef
  • Development and validation of a nomogram prediction model for thyroid dysfunction in patients with type 2 diabetes mellitus
    Yinghao Niu, Zhihua Chen, Yating Li, Li Liu, Xuan Wang, Jun Wang, Dan Song
    Scientific Reports.2026;[Epub]     CrossRef
  • Impact of thyroid diseases on urinary stone composition: a decade-Long analysis based on propensity score matching
    Mengting Wang, Kemin Liu, Qianjun Li, Kunzhi Luo, Weizhi Zheng, Yiping Lai, Haojie Wu, Ying Liang, Baoqing Sun, Guohua Zeng, Zhenglin Chang
    World Journal of Urology.2026;[Epub]     CrossRef
  • Intentional co-ingestion of levothyroxine and insulin in a teenager
    Sarah El Yaman, Kathryn Swaby, Jeffrey N. Bernstein, Janine E. Sanchez
    Journal of Diabetes & Metabolic Disorders.2026;[Epub]     CrossRef
  • Thyroid and adrenal autoimmunity in children with newly diagnosed type 1 diabetes mellitus
    Orla Dempsey, Jonathan Pinsker, Angela Lucas-Herald, Gavin Allison, Karen Whyte, Vaiva Sadauskaite Kuehne, Hilary Pearce, Amita Sharma, Rajeeb Rashid, Jane Delamere McNeilly, M. Guftar Shaikh
    Journal of Pediatric Endocrinology and Diabetes.2026; 5: 150.     CrossRef
  • Prevalence and Clinical Impact of Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus: A Case-Control Study in a Tertiary Care Setting
    Bhagyashree ., Pratima .
    International Journal of Science and Healthcare Research.2026; : 147.     CrossRef
  • Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study
    Xiaorong Wang, Congqin Zhang, Xue Zhao, Sinan Zhao, Fang Zhang, Chunhui Li, Yongmei Hao
    Diabetes, Metabolic Syndrome and Obesity.2026; Volume 19: 1.     CrossRef
  • Screening for metabolic syndrome in patients newly diagnosed with hypothyroidism to identify the compounding effect on cardiovascular disease risk
    Arslan Mohammed, Suchitra M. Manohar, Kusuma Kumari M., Alok Sachan
    International Journal of Research in Medical Sciences.2026; 14(3): 1071.     CrossRef
  • Nonlinear Association Between THs, TSH, and HbA1c in Patients With Type 2 Diabetes Mellitus: A Retrospective Study
    Mengjie Chen, Yuqin Gan, Fengxiang Tian, Yun Bao, Zhonglan Chen
    Journal of Diabetes.2026;[Epub]     CrossRef
  • Correlation Between the Thyroid Hormone Levels and Type 2 Diabetes Mellitus in Non-Alcoholic Fatty Liver Disease
    Liya Bian, Hua Fan, Qingwen Yu, Xiyun Rao, Ting Tang, Lanlan Feng, Yongmin Shi, Xuhan Tong, Xingwei Zhang, Jiake Tang, Pengwei Zhang, Mingwei Wang, Xianguo Qu
    Diabetes, Metabolic Syndrome and Obesity.2026; Volume 19: 1.     CrossRef
  • Prognostic significance of preoperative thyroid hormone sensitivity status for recurrence in papillary thyroid carcinoma
    Canxiao Li, Shijie Li, Yishen Zhao, Daqi Zhang, Yantao Fu, Le Zhou, Jingting Li, Fang Li, Rui Du, Nan Liang, Hui Sun
    The Oncologist.2026;[Epub]     CrossRef
  • Methimazole-induced hypothyroidism disrupts testicular glycogen regulation without affecting insulin expression or signaling in rats
    Roberta da Fonseca Coutinho Pontes, Juliana Santos Romão, Nathalia Pereira de Farias da Silva, Manuela Farias Joppert, Ana Clara Chagas Coutinho Pontes, Lorena Cristina Souza e Souza, Cherley Borba Vieira Andrade, Veronica Aiceles, José Antônio Silva Riba
    Molecular and Cellular Endocrinology.2026; 618: 112793.     CrossRef
  • Aescin and rutin mitigate hyperthyroidism-induced multisystem dysfunction via antioxidant and anti-inflammatory mechanisms in a rat model
    Minnatullah A. Makadi, Ibrahim A. Ibrahim, Hoda I. Bahr, Amr Elkelish, Zongo Oumarou, Hassan Rudayni, Amal A. M. Ahmed, Yasmina K. Mahmoud
    Scientific Reports.2026;[Epub]     CrossRef
  • Tirzepatide and thyroid function in adults with type 2 diabetes or obesity: a systematic evidence map and data gap analysis
    Danilo Caponio, Giuseppina Alessia Acucella
    Obesity Medicine.2026; 61: 100696.     CrossRef
  • SAGE-DM—Senescence-Associated Gluco-Endocrinopathy Diabetes Mellitus: comprehensive review
    Michał Szklarz, Katarzyna Wołos-Kłosowicz, Julia Modzelewska, Jan Górny, Robert Modzelewski, Wojciech Matuszewski
    European Journal of Medical Research.2026;[Epub]     CrossRef
  • Letter to the Editor: Prevalence of subclinical hypothyroidism and longitudinal thyroid stimulating hormone changes in youth with metabolic dysfunction–associated steatotic liver disease: An observational study
    Anna Di Sessa, Emanuele Miraglia del Giudice
    Hepatology.2025; 82(1): E1.     CrossRef
  • Thyroid hormone and the Liver
    Lorraine Soares De Oliveira, Megan J. Ritter
    Hepatology Communications.2025;[Epub]     CrossRef
  • Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns
    Josip Djelmis, Marina Ivanisevic
    Scientific Reports.2025;[Epub]     CrossRef
  • Detection rate and clinical characteristics of coexisting autoimmune diseases in children with Graves’ disease: a single-center study from China
    Yang Li, Mu-Qiao Yan, Yan-Ning Song, Qin Zhang, Chun-Xiu Gong
    Endocrine.2025; 88(1): 143.     CrossRef
  • When Should the Treatment of Obesity in Thyroid Disease Begin?
    Edyta Sutkowska, Michał Kisiel, Agnieszka Zubkiewicz-Kucharska
    Biomedicines.2025; 13(1): 157.     CrossRef
  • Spectrum of thyroid disorders among patients with type 2 diabetes mellitus
    Md Rakibul Hasan, Raisa Siddika, Sayma Akther Mou, Md Shahed Morshed
    IMC Journal of Medical Science.2025; : 1.     CrossRef
  • Hypoglycemia and hospital mortality in critically ill patients
    Hsuan-Fan Yeh, Wen-Cheng Chao, Chieh-Liang Wu, Ming-Cheng Chan
    Scientific Reports.2025;[Epub]     CrossRef
  • Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study
    Yaling Fang, Xin Wen, Hui You, Yueye Huang, Shen Qu, Xingchun Wang, Le Bu
    Frontiers in Nutrition.2025;[Epub]     CrossRef
  • Associations between indicators of lipid and glucose metabolism and hypothyroidism
    Xinyi Huang, Hengzheng Cheng, Shuting Wang, Laifu Deng, Jiaxiu Li, An Qin, Chunqiang Chu, Xiao Liu
    Lipids in Health and Disease.2025;[Epub]     CrossRef
  • Thyroid Stimulatory Activity of Houttuynia cordata Thunb. Ethanolic Extract in 6-Propyl-Thiouracil-Induced Hypothyroid and STZ Induced Diabetes Rats: In Vivo and In Silico Studies
    Shaikh Shahinur Rahman, Anuwatchakij Klamrak, Nirmal Chandra Mahat, Rakibul Hasan Rahat, Napapuch Nopkuesuk, Md Kamruzzaman, Piyapon Janpan, Yutthakan Saengkun, Jaran Nabnueangsap, Thananya Soonkum, Padol Sangkudruea, Nisachon Jangpromma, Sirinan Kulchat,
    Nutrients.2025; 17(3): 594.     CrossRef
  • Exploring the Link Between Thyroid Disorders and Obesity: Mechanisms, Impacts, and Clinical Implications
    Ashni Dharia, Dimpi Desai, Kaniksha Desai
    Endocrine Practice.2025; 31(5): 660.     CrossRef
  • A Retrospective Analysis of the Changes in Prediabetes-Associated Markers of Thyroid Function in Patients from Durban, South Africa
    Hasnaa Satar Aswani, Wendy Mdluli, Andile Khathi
    International Journal of Molecular Sciences.2025; 26(5): 2170.     CrossRef
  • Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis
    Yanan Li, Shuai Yang, Zixuan Huang, Yong Zhang, Haixia Guan, Jianxia Fan
    Nutrition & Metabolism.2025;[Epub]     CrossRef
  • Prevalence and Association of Thyroid Dysfunction With Diabetes Mellitus in a Tertiary Care Hospital: A Retrospective Study
    Vignesh Babu K, Pavalaveelzi CM, Kuzhandai Velu V, Yuvaraj SS
    Cureus.2025;[Epub]     CrossRef
  • Association Between Maternal Thyroid Hormone Concentration with Normal Thyroid Function During Pregnancy and Preschoolers’ Glycolipid Metabolism: A Birth Cohort Study
    Wenjin Cai, Lu Chen, Manyu Zhang, Jiajun Ouyang, Penggui Wu, Juan Tong, Guopeng Gao, Shuangqin Yan, Fangbiao Tao, Kun Huang
    Thyroid®.2025; 35(4): 444.     CrossRef
  • Impact of Thyroid Dysregulation on Glycemic Control in Type 2 Diabetes Mellitus: A Comparative Investigation
    Farmanullah, Hayat Ur Rahman, Naseem Khan, Asad Ullah, Waseem Abbas
    Indus Journal of Bioscience Research.2025; 3(2): 586.     CrossRef
  • Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes
    Jiang Li, Jie Li, Ying Sun, Yanqi Fu, Wenqi Shen, Lingli Cai, Fei Xu, Ling Gao, Ningjian Wang, Bin Wang, Yingli Lu
    The Journal of nutrition, health and aging.2025; 29(6): 100543.     CrossRef
  • Positive association between stress hyperglycemia ratio and ICU mortality in patients with pulmonary embolism: A retrospective study
    Jian Liao, Dingyu Lu, Maojuan Wang, Hanyang Yu, Elizabeth S. Mayne
    PLOS ONE.2025; 20(3): e0320644.     CrossRef
  • Relationship between urinary iodine concentration and all-cause mortality in individuals with diabetes: An analysis of National Health and Nutrition Examination Survey 2005 - 2018
    Xin Lai, Leihua Zhang
    Hormones.2025; 24(3): 775.     CrossRef
  • Association between thyroid stimulating hormone levels and nonproliferative diabetic retinopathy: a cross-sectional study
    Yiqi Xu, Biwu Dong, Youyun Tang, Yan Jiang, Tingting Huang, Feng Jiang, Wei Xing, Junsheng Chen, Fengping Zhu
    BMC Endocrine Disorders.2025;[Epub]     CrossRef
  • Long-term Nonskeletal Complications in Patients With Thyroid Cancer and Hypoparathyroidism Post Total Thyroidectomy
    Eu Jeong Ku, Jooyoung Lee, Won Sang Yoo, Janghyeon Bae, Eun Kyung Lee, Hwa Young Ahn
    The Journal of Clinical Endocrinology & Metabolism.2025; 110(12): 3538.     CrossRef
  • Effect of Empagliflozin on Serum Levels of Thyroid Hormones Among Prediabetic and Diabetic Patients
    Mojgan Sanjari, Narges Sadeghi, Ladan Amirkhosravi, Mohammad Hadavizadeh, Ahmad Naghibzadeh-Tahami, Zohreh Safi, Suraiya Saleem
    International Journal of Endocrinology.2025;[Epub]     CrossRef
  • Effect of apelin level in Iraqi diabetic women with hypothyroidism
    Maryam Qusay Isaa, Noor Thair Tahir
    Polski Merkuriusz Lekarski.2025; 53(2): 218.     CrossRef
  • The Intricate Relationship Between Thyroid Disorders and Type 2 Diabetes—A Narrative Review
    Dana-Mihaela Tilici, Diana Loreta Paun, Ana Maria Arnautu, Alexandra Mirica, Carmen Duta, Mirona Costea, Cristian Guja
    Diabetology.2025; 6(5): 41.     CrossRef
  • Jod-Basedow Phenomenon Precipitating Diabetic Ketoacidosis: A Case Report
    Abin Thomas, Jerin Varghese, Sreekrishnan Trikkur, Gireesh Kumar
    Cureus.2025;[Epub]     CrossRef
  • Association of maternal thyroid function and gestational diabetes with pregnancy outcomes: a retrospective cohort study
    Chang Zou, Qinxin Shen, Yuanyuan Yang, Yini Liao, Qiaoling Du
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
  • Circulating leptin levels in thyroid dysfunction: a systematic review and meta-analysis
    Shanshan Liu, Jun Ma, Leyuan Zhang, Yanlong Yang, Ziqi Han, Limin Tian
    BMC Endocrine Disorders.2025;[Epub]     CrossRef
  • Incidental hyperglycemia in women at reproductive age and its association with thyrotropin levels: A population-based cohort study in China
    Ying Yang, Xinyi Lyu, Jinrong Fu, Jueming Lei, Hanbin Wu, Chuanyu Zhao, Meiya Liu, Xuan Hu, Jiaxin Li, Yuanyuan Wang, Yuan He, Zuoqi Peng, Ya Zhang, Hongguang Zhang, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Xu Ma, Haixia Guan
    Diabetes Research and Clinical Practice.2025; 226: 112345.     CrossRef
  • Assessing thyroid health: phenotypic age compared to chronological age
    Dongyu Yang, Cihang Lu, Haonan Zhang, Xiaoguang Shi, Ying Sun, Ying Shao, Shuting Fan, Lijun Tian, Di Teng
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
  • Association of Thyroid-Stimulating Hormone Levels with Incident Cardiovascular Events in People Aged 40 Years and Older: A 10-Year Prospective Cohort Study
    Sai Yan, Miao Zhang, Ying Hu, Rui Wang, Juan He, Qiao Zhang, Lixin Shi, Nianchun Peng
    Bratislava Medical Journal.2025; 126(10): 2795.     CrossRef
  • Association of thyroid function within the normal range with glycemic control and cardiovascular risk factors in type 1 diabetes
    Mariana Lourenço, Ana Rita Leite, Patrícia Ferreira, Inês Meira, João Menino, Ana Margarida Lopes, Joana Lagoa, Beatriz Viveiros, Maria João Barbosa, Sílvia Santos Monteiro, Joana Queirós, João Sérgio Neves, Celestino Neves
    Expert Review of Endocrinology & Metabolism.2025; 20(5): 415.     CrossRef
  • Critical illness-implications of non-thyroidal illness syndrome and thyroxine therapy
    Christos Savvidis, Dimitra Ragia, Efthymia Kallistrou, Eleni Kouroglou, Vasiliki Tsiama, Stella Proikaki, Konstantinos Belis, Ioannis Ilias
    World Journal of Critical Care Medicine.2025;[Epub]     CrossRef
  • Trimester-specific thyroid function markers and gestational diabetes risk: evidence from a tertile-based cohort of euthyroid pregnancies
    Erkan Sağlam, Serenat Eris Yalçın, Mustafa Raşit Özler, Bekır Siddik Yılmaz, Nuray Nerez
    The Journal of Maternal-Fetal & Neonatal Medicine.2025;[Epub]     CrossRef
  • Impact of high-normal TSH in early pregnancy on gestational diabetes mellitus: a retrospective cohort study
    Li Yang, Xiangming Tian, Yongjun Lu, Wenying Meng
    The Journal of Maternal-Fetal & Neonatal Medicine.2025;[Epub]     CrossRef
  • The status of thyroid disorders among patients with type 2 diabetes mellitus in Guilan province, Iran
    Maryam Yaseri, Haniyeh Sadat Fayazi, Fatemeh Mahdi, Faezeh Motevali, Seyedeh Sahereh Mortazavi Khatibani
    Endocrine and Metabolic Science.2025; 19: 100267.     CrossRef
  • Opioid-Induced Hypoglycemia in Diabetes: Dose-Dependent Effects of Methadone in a Complex Chronic Pain Patient
    Omar Shazley, Christina Orr
    Cureus.2025;[Epub]     CrossRef
  • Inverse Association Between the Dawn Phenomenon and Thyroid Feedback Quantile-Based Index in Type 2 Diabetes Using Continuous Glucose Monitoring: A Cross-Sectional Study
    Yan Xia, Hong-jing Chen, Reng-na Yan, Xiao-wei Zhu, Han Zhao, Bo Ding, Yun Hu
    Diabetes, Metabolic Syndrome and Obesity.2025; Volume 18: 3465.     CrossRef
  • Dietary Dityrosine Impairs Glucose Homeostasis by Disrupting Thyroid Hormone Signaling in Pancreatic β-Cells
    Yueting Ge, Boyang Kou, Chunyu Zhang, Chengjia Gu, Lin Cheng, Yonghui Shi, Guowei Le, Wei Xu
    Foods.2025; 14(18): 3220.     CrossRef
  • Peripheral Thyroid Hormone Sensitivity Mediates the Association Between Body Composition and Diabetes in Euthyroid Adults
    Nanfang Yao, Lan Liu, Yuqi Jiang, Dongmei Wang, Qianyi Lu, Yi Zeng, Genfeng Yu, Qintao Ma, Peiyi Li, Lingling Liu, Jie Shen, Heng Wan
    Journal of Cachexia, Sarcopenia and Muscle.2025;[Epub]     CrossRef
  • Integrated network pharmacology and cellular assay revealed an anti-type 2 diabetes effect of Astaxanthin from Haematococcus pluvialis
    Ran Chen, Shilin Wu, Zhen Zhang, Kun Li, Jingyun Chen, Ning Yang, Hongxiang Zhao, Rongqing Zhang
    Algal Research.2025; 91: 104318.     CrossRef
  • Impact of subclinical hypothyroidism on glycemic markers and insulin resistance in nondiabetic Iraqi patients: a cross-sectional study
    Maysam Riyadh Mohammed Hussein Alaasam, Raffat Hilal Abboodi, Hayder Nadhim Mohsin Al-Khayyat
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2025; 21(6): 583.     CrossRef
  • Proenkephalin-A as a Biomarker for Type 2 Diabetes in Women with Thyroid Disorders
    Maryam A. Hassoun, Eiman A.A. Abass
    Journal of the Faculty of Medicine Baghdad.2025; 67(3): 395.     CrossRef
  • Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework
    Nicholas Thomas, Danijela Tatovic, Angus Jones, Parth Narendran
    The Lancet Diabetes & Endocrinology.2025; 13(11): 980.     CrossRef
  • Exploring the associations of the triglyceride‒glucose index with thyroid function in subclinical hypothyroid patients: a cross-sectional study
    Fawad Inayat, Sulaiman Shams, Noor Ullah, Arsalan Waqas Ahmad Shah, Ihtesham Ul Haq
    Lipids in Health and Disease.2025;[Epub]     CrossRef
  • Mediterranean Diet Adherence and One-Year Metabolic Changes in Patients with Papillary Thyroid Cancer: An Observational Study
    Jinyoung Shin, Seok-Jae Heo, Yae-Ji Lee, Sang-Wook Kang, Yu-Jin Kwon, Ji-Won Lee
    Nutrients.2025; 17(21): 3420.     CrossRef
  • A Mathematical Modeling Approach to Estimate Blood Glucose Behavior in Individuals with Prediabetes
    Alexis Alonso-Bastida, Dolores Azucena Salazar-Piña, Manuel Adam-Medina, Lourdes Gutiérrez-Xicotencatl, Christian Ríos-Enríquez, Margarita Ramos-García, Daniel Villanueva-Vásquez
    Diabetology.2025; 6(11): 123.     CrossRef
  • Comparison of Thyroid Dysfunction in Patients with Controlled Versus Uncontrolled Diabetes Mellitus: A Comparative Cross-Sectional Study
    Khansa Qamar, Masud Ali Ansari, Mahneem Tofique, Jannat Naeem, Sara Shams, Fizza Fatima
    Pakistan Journal of Health Sciences.2025; : 61.     CrossRef
  • The most common endocrine disorders in pregnancy
    Zagorka Milovanović, Dejan Filimonović
    Medicinski podmladak.2025; 76(3): 42.     CrossRef
  • Autoimmune thyroid disease and human health: a systematic review of Mendelian randomization studies
    Peijin Li, Qian Wang, Yan Yang, Zhiguo Ding
    Frontiers in Immunology.2025;[Epub]     CrossRef
  • Serum Lipid Profile and Atherogenic Risk in Thyroid Dysfunction: A Cross-sectional Study
    Prashant Nigam, Hrishikesh Mishra, Somya Rakesh, Pooja Soni, Priyanshu Soni, Palak Mohan, Afsana Parveen, Supriya Bharti
    Indian Journal of Medical Biochemistry.2025; 30(1): 40.     CrossRef
  • Linkage and association of rs3110045 and rs28499085 variants in the thyrotropin-releasing hormone receptor (TRHR) gene with the risk of familial type 2 diabetes
    Rongling Wu, Claudia Gragnoli
    Aspects of Molecular Medicine.2024; 3: 100037.     CrossRef
  • Association between eating speed and atherosclerosis in relation to growth differentiation factor-15 levels in older individuals in a cross-sectional study
    Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Nagisa Sasaki, Mutsumi Matsuyama, Seiko Nakamichi, Kazuhiko Arima, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
    Scientific Reports.2024;[Epub]     CrossRef
  • Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?
    Sebastián Pablo Chapela, Alison Simancas-Racines, Florencia Ceriani, Andrés Luciano Nicolas Martinuzzi, María Paula Russo, Ana Karina Zambrano, Daniel Simancas-Racines, Ludovica Verde, Giovanna Muscogiuri, Christos S. Katsanos, Evelyn Frias-Toral, Luigi B
    Current Nutrition Reports.2024; 13(2): 194.     CrossRef
  • View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences
    Guglielmina Froldi
    Pharmaceuticals.2024; 17(4): 478.     CrossRef
  • Thyroid Hormones and Diabetes in Euthyroid Hispanic/Latino Adults of Diverse Backgrounds: HCHS/SOL
    Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M Sargis, Martha Daviglus, Jianwen Cai, Sally Freels, Robert Kaplan, Carmen R Isasi, Amber Pirzada, Michelle L Meyer, Gregory A Talavera, Bharat Thyagarajan, Shivani Agarwal, No
    Journal of the Endocrine Society.2024;[Epub]     CrossRef
  • Increased frequency of microalbuminuria in patients with type 3 autoimmune polyglandular syndrome (APS) compared to isolated autoimmune type 1 diabetes mellitus: A real-life study
    Stefano Radellini, Enrica Vigneri, Ornella Ferreri, Piero Luigi Almasio, Giuseppe Pizzolanti, Carla Giordano, Valentina Guarnotta
    Diabetes Research and Clinical Practice.2024; 213: 111746.     CrossRef
  • Adaptive Effects of Endocrine Hormones on Metabolism of Macronutrients during Fasting and Starvation: A Scoping Review
    Reza Karimi, Alina Yanovich, Fawzy Elbarbry, Anita Cleven
    Metabolites.2024; 14(6): 336.     CrossRef
  • Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study
    Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim
    BMC Medicine.2024;[Epub]     CrossRef
  • Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ
    Georg Sebastian Hönes, Daniela Geist, Christina Wenzek, Paul Thomas Pfluger, Timo Dirk Müller, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Natalia Dragano, Lillian Garrett, Sabine Maria Hölter, Birgit Rathkolb, Jan Rozman, Nadine Spi
    Endocrinology.2024;[Epub]     CrossRef
  • Correlation of serum thyrotropin and thyroid hormone levels with diabetic kidney disease: a cross-sectional study
    Jie Gao, Jingfang Liu
    BMC Endocrine Disorders.2024;[Epub]     CrossRef
  • The prevalence and determinants of diabetes mellitus and thyroid disorder comorbidity in Tabari cohort population
    Mahmood Moosazadeh, Saeedeh Khakhki, Adele Bahar, Akbar Hedayatizadeh-Omran, Motahareh Kheradmand, Reza Alizadeh-Navaei, Erfan Ghadirzadeh
    Scientific Reports.2024;[Epub]     CrossRef
  • Maternal hypothyroidism and subsequent metabolic outcomes in children: a systematic review and meta-analysis
    Lucy Zhao, Inthuja Selvaratnam, Jessie Cunningham, Kristian B. Filion, Sonia M. Grandi
    BMC Pediatrics.2024;[Epub]     CrossRef
  • Thyroid Hormone and Diabetes Mellitus Interplay: Making Management of Comorbid Disorders Complicated
    Ayush Chauhan, Snehal S Patel
    Hormone and Metabolic Research.2024; 56(12): 845.     CrossRef
  • Effects of moderate physical activity on diabetic adhesive capsulitis: a randomized clinical trial
    Raheela Kanwal Sheikh, Amna Toseef, Aadil Omer, Anam Aftab, Muhammad Manan Haider Khan, Saeed Bin Ayaz, Omar Althomli, Aisha Razzaq, Samra Khokhar, Nazia Jabbar, Waqar Ahmed Awan
    PeerJ.2024; 12: e18030.     CrossRef
  • Gene biomarkers for the assessment of thyroid-disrupting activity in zebrafish embryos
    Fabian Essfeld, Benedikt Luckner, Antonia Bruder, Fatma Marghany, Steve Uwa Ayobahan, Julia Alvincz, Sebastian Eilebrecht
    Chemosphere.2024; 365: 143287.     CrossRef
  • Tailoring an antihyperglycaemic regimen to a monogenic diabetes variant
    Samuel Nemiroff, Peter Goulden
    BMJ Case Reports.2024; 17(9): e260703.     CrossRef
  • Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil
    Alessandro Pingitore, Melania Gaggini, Francesca Mastorci, Laura Sabatino, Linda Cordiviola, Cristina Vassalle
    International Journal of Molecular Sciences.2024; 25(19): 10628.     CrossRef
  • Correlation Analysis of 25 Hydroxyvitamin D, Lipid Indexes and Thyroid Nodules in Patients with Type 2 Diabetic Mellitus
    文静 魏
    Advances in Clinical Medicine.2024; 14(10): 1452.     CrossRef
  • Managing Adults With Hypoglycemia
    Christopher James Watson, Jonathan A. Edlow
    Annals of Emergency Medicine.2023; 82(6): 705.     CrossRef
  • Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes
    Josip Delmis, Slavko Oreskovic, Vesna Elvedji Gasparovic, Mirta Starcevic, Mislav Herman, Nada Dessardo, Vito Starcevic, Marina Ivanisevic
    Nutrients.2023; 15(3): 600.     CrossRef
  • Isolated Maternal Hypothyroxinemia May be Associated with Insulin Requirement in Gestational Diabetes Mellitus
    Ömercan Topaloğlu, Mehmet Uzun, Seda Nur Topaloğlu, Ibrahim Sahin
    Hormone and Metabolic Research.2023; 55(04): 245.     CrossRef
  • Association of urinary iodine concentration with prediabetes/diabetes in adults: Analysis of the NHANES 2005–2016
    Jingmin Chen, Huanzhu Liang, Yuxuan Tan, Lin Wen, Ziang Guo, Jiyu Nie, Xiaoxiao Lin, Feng Huang, Jie Wang, Puyi Xing, Lihong Nie, Lihong Wang, Chunxia Jing
    Journal of Trace Elements in Medicine and Biology.2023; 77: 127144.     CrossRef
  • Central sensitivity to thyroid hormones is reduced in youths with overweight or obesity and impaired glucose tolerance
    Procolo Di Bonito, Domenico Corica, Maria Rosaria Licenziati, Anna Di Sessa, Emanuele Miraglia del Giudice, Maria Felicia Faienza, Valeria Calcaterra, Francesca Franco, Giulio Maltoni, Giuliana Valerio, Malgorzata Wasniewska
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Association of thyroid stimulating hormone and time in range with risk of diabetic retinopathy in euthyroid type 2 diabetes
    Yaxin Wang, Jingyi Lu, Jiaying Ni, Ming Wang, Yun Shen, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou
    Diabetes/Metabolism Research and Reviews.2023;[Epub]     CrossRef
  • The circadian rhythm: an influential soundtrack in the diabetes story
    Amirali Hariri, Mina Mirian, Ali Zarrabi, Mohammad Kohandel, Maryam Amini-Pozveh, Amir Reza Aref, Aliye Tabatabaee, Pranav Kumar Prabhakar, Ponnurengam Malliappan Sivakumar
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Folate deficiency may increase the risk for elevated TSH in patients with type 2 diabetes mellitus
    Lin Lin, Yushan Du, Guanyu Niu, Shuangbo Xia, Jufen Liu
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • L- Thyroxine ameliorates renal function in thyroidectomized diabetic nephropathy rats through downregulation of TGF- β1, Ang II and ET-1 expression
    Zeinab H. El-Said, Sherihan I. Gouda, Hebatallah A. Mahgoub, S El_desouky, Neven A. Ebrahim
    Egyptian Journal of Basic and Applied Sciences.2023; 10(1): 632.     CrossRef
  • Thyroid dysfunction in children and adolescents affected by undernourished and overnourished eating disorders
    Valeria Calcaterra, Vittoria Carlotta Magenes, Francesca Siccardo, Chiara Hruby, Martina Basso, Veronica Conte, Giulia Maggioni, Valentina Fabiano, Susanna Russo, Pierangelo Veggiotti, Gianvincenzo Zuccotti
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Preventive Effect of Molecular Iodine in Pancreatic Disorders from Hypothyroid Rabbits
    Julia Rodríguez-Castelán, Evangelina Delgado-González, Esteban Rodríguez-Benítez, Francisco Castelán, Estela Cuevas-Romero, Brenda Anguiano, Michael C. Jeziorski, Carmen Aceves
    International Journal of Molecular Sciences.2023; 24(19): 14903.     CrossRef
  • Hypothyroidism increases angiotensinogen gene expression associated with vascular smooth muscle cells cholesterol metabolism dysfunction and aorta remodeling in Psammomys obesus
    Samia Neggazi, Nadjiba Hamlat, Sihem Berdja, Saliha Boumaza, Leila Smail, Michel Beylot, Souhila Aouichat-Bouguerra
    Scientific Reports.2023;[Epub]     CrossRef
  • The Correlation Between Thyroid Parameters and the Ratios of Neutrophil/Lymphocyte and Platelet/Lymphocyte in Euthyroid Type 2 Diabetic Patients
    Hui Chen, Jun-Qiang Ju, Xiao-Wu Qian, Zheng-Tai Zhu, Chun-Zhi Zhao, Zhe Liu
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3763.     CrossRef
  • Effects of high-intensity interval training program on pituartry function in basketball players: a randomized controlled trial
    Recep Soslu, Abdullah Uysal, Meltem Devrilmez, İsmail Can Çuvalcıoğlu, Ali Ahmet Doğan, Sülbiye Karaburgu, Murat Taş
    Frontiers in Physiology.2023;[Epub]     CrossRef
  • Selenium and Selenoproteins at the Intersection of Type 2 Diabetes and Thyroid Pathophysiology
    Francesca Gorini, Cristina Vassalle
    Antioxidants.2022; 11(6): 1188.     CrossRef
  • TSH levels within the normal range and risk of cardiovascular and all-cause mortality among individuals with diabetes
    Ping Zhu, Guojuan Lao, Chuping Chen, Lihui Luo, Jing Gu, Jianmin Ran
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves’ Disease
    Ho Yeop Lee, Byeong Chang Sim, Ha Thi Nga, Ji Sun Moon, Jingwen Tian, Nguyen Thi Linh, Sang Hyeon Ju, Dong Wook Choi, Daiki Setoyama, Hyon-Seung Yi
    Endocrinology and Metabolism.2022; 37(6): 891.     CrossRef
  • Glycation of Hemoglobin Among Individuals With Subclinical Hypothyroidism - An Urban Cross-Sectional Study
    Samarpita Mukherjee, Saha Shubhrajit
    Journal of Applied Biochemistry & Laboratory Medicine.2022; 3(1): 27.     CrossRef
Original Articles
Basic Research
Article image
Notch1 Has an Important Role in β-Cell Mass Determination and Development of Diabetes
Young Sil Eom, A-Ryeong Gwon, Kyung Min Kwak, Jin-Young Youn, Heekyoung Park, Kwang-Won Kim, Byung-Joon Kim
Diabetes Metab J. 2021;45(1):86-96.   Published online February 26, 2020
DOI: https://doi.org/10.4093/dmj.2019.0160
  • 10,686 View
  • 221 Download
  • 18 Web of Science
  • 18 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background

Notch signaling pathway plays an important role in regulating pancreatic endocrine and exocrine cell fate during pancreas development. Notch signaling is also expressed in adult pancreas. There are few studies on the effect of Notch on adult pancreas. Here, we investigated the role of Notch in islet mass and glucose homeostasis in adult pancreas using Notch1 antisense transgenic (NAS).

Methods

Western blot analysis was performed for the liver of 8-week-old male NAS mice. We also conducted an intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test in 8-week-old male NAS mice and male C57BL/6 mice (control). Morphologic observation of pancreatic islet and β-cell was conducted in two groups. Insulin secretion capacity in islets was measured by glucose-stimulated insulin secretion (GSIS) and perifusion.

Results

NAS mice showed higher glucose levels and lower insulin secretion in IPGTT than the control mice. There was no significant difference in insulin resistance. Total islet and β-cell masses were decreased in NAS mice. The number of large islets (≥250 µm) decreased while that of small islets (<250 µm) increased. Reduced insulin secretion was observed in GSIS and perifusion. Neurogenin3, neurogenic differentiation, and MAF bZIP transcription factor A levels increased in NAS mice.

Conclusion

Our study provides that Notch1 inhibition decreased insulin secretion and decreased islet and β-cell masses. It is thought that Notch1 inhibition suppresses islet proliferation and induces differentiation of small islets. In conclusion, Notch signaling pathway may play an important role in β-cell mass determination and diabetes.

Citations

Citations to this article as recorded by  
  • A genetics-guided integrative framework for drug repurposing: identifying antihypertensive drugs for type 2 diabetes
    Xue Zhong, Qiang Wei, Anshul Tiwari, Quan Wang, Yuting Tan, Rui Chen, Yan Yan, Nancy J. Cox, Bingshan Li
    npj Drug Discovery.2026;[Epub]     CrossRef
  • T‑cadherin and its impact on human diseases (Review)
    Yan Song, Xinyi Wang, Yunfei Bian
    Molecular Medicine Reports.2026; 33(4): 1.     CrossRef
  • Translational disease modeling of peripheral blood identifies type 2 diabetes biomarkers predictive of Alzheimer’s disease
    Brendan K. Ball, Jee Hyun Park, Alexander M. Bergendorf, Elizabeth A. Proctor, Douglas K. Brubaker
    npj Systems Biology and Applications.2025;[Epub]     CrossRef
  • Pancreatic β-cell remodeling in health and aging: Lessons from rodents and humans
    Radwan Darwish, Yasmine Alcibahy, Sangeeta Dhawan, Alexandra E. Butler, Abu Saleh Md Moin
    Ageing Research Reviews.2025; 110: 102815.     CrossRef
  • LATE-ONSET NEVUS COMEDONICUS IN AN ADULT PATIENT WITH DIABETES MELLITUS
    Metin Özaslan, Zeliha Çelik
    Kırıkkale Üniversitesi Tıp Fakültesi Dergisi.2025; 27(2): 246.     CrossRef
  • Rheb1 as a novel β-cell regulator connecting mTORC1, AMPK, and NOTCH1 pathways for efficient diabetes therapy
    Mostafa M Gouda
    World Journal of Diabetes.2025;[Epub]     CrossRef
  • Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy
    Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Luigi Bouchard, Marie-France Hivert
    Frontiers in Endocrinology.2025;[Epub]     CrossRef
  • Notch signaling in metabolic diseases: A key regulator and potential target
    Zhaoqing Xi, Junxia Zhang, Mingwei Bao
    Biochemical and Biophysical Research Communications.2025; 781: 152492.     CrossRef
  • The stem cell within the vessel wall: multipotent pericytes modulating β-cell function and diabetic complications
    Huanjing Bi, Ruiyang Ma, Zuhan Chen, Ying Wang, Xiaoming Ding
    Stem Cell Research & Therapy.2025;[Epub]     CrossRef
  • Investigating the Potential Molecular Mechanisms of Mogroside V on Glucose Homeostasis by Transcriptome Profiling of Adult Mouse Hypothalamic Cells
    Tomasz Szmatoła, Artur Gurgul, Ewa Ocłoń, Igor Jasielczuk, Ewelina Semik-Gurgul
    Applied Sciences.2025; 15(23): 12391.     CrossRef
  • The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight
    Elena Klyosova, Iuliia Azarova, Irina Petrukhina, Ramis Khabibulin, Alexey Polonikov
    International Journal of Obesity.2024; 48(11): 1638.     CrossRef
  • Identification of Immune Gene Signature Associated with T Cells and Natural Killer Cells in Type 1 Diabetes
    Na Wang, Guofeng Wang, Xiuli Feng, Teng Yang
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 2983.     CrossRef
  • N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway
    Ying Cai, Tao Chen, Mingzhu Wang, Lihua Deng, Cui Li, Siqian Fu, Kangling Xie
    Diabetes Research and Clinical Practice.2023; 197: 110261.     CrossRef
  • Single‐cell RNA sequencing: Inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia
    Yunqian Yao, Ling Wei, Zhenhua Chen, Hao Li, Jiao Qi, Qingfeng Wu, Xingtao Zhou, Yi Lu, Xiangjia Zhu
    Cell Proliferation.2023;[Epub]     CrossRef
  • Micro ribonucleic acid‐363 regulates the phosphatidylinositol 3‐kinase/threonine protein kinase axis by targeting NOTCH1 and forkhead box C2, leading to hepatic glucose and lipids metabolism disorder in type 2 diabetes mellitus
    Yu‐Huan Peng, Ping Wang, Xiao‐Qun He, Ming‐Zhao Hong, Feng Liu
    Journal of Diabetes Investigation.2022; 13(2): 236.     CrossRef
  • Soluble T-cadherin promotes pancreatic β-cell proliferation by upregulating Notch signaling
    Tomonori Okita, Shunbun Kita, Shiro Fukuda, Keita Fukuoka, Emi Kawada-Horitani, Masahito Iioka, Yuto Nakamura, Yuya Fujishima, Hitoshi Nishizawa, Dan Kawamori, Taka-aki Matsuoka, Maeda Norikazu, Iichiro Shimomura
    iScience.2022; 25(11): 105404.     CrossRef
  • Comparison of islet isolation result and clinical applicability according to GMP‐grade collagenase enzyme blend in adult porcine islet isolation and culture
    Kyungmin Kwak, Jae‐kyung Park, Joohyun Shim, Nayoung Ko, Hyoung‐Joo Kim, Yongjin Lee, Jun‐Hyeong Kim, Michael Alexander, Jonathan R. T. Lakey, Hyunil Kim, Kimyung Choi
    Xenotransplantation.2021;[Epub]     CrossRef
  • Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas
    Adem Y. Dawed, Sook Wah Yee, Kaixin Zhou, Nienke van Leeuwen, Yanfei Zhang, Moneeza K. Siddiqui, Amy Etheridge, Federico Innocenti, Fei Xu, Josephine H. Li, Joline W. Beulens, Amber A. van der Heijden, Roderick C. Slieker, Yu-Chuan Chang, Josep M. Mercade
    Diabetes Care.2021; 44(12): 2673.     CrossRef
Evaluation of Stress in Korean Patients with Diabetes Mellitus Using the Problem Areas in Diabetes-Korea Questionnaire
Young Sil Eom, Hwa Sun Park, Sei-Hyun Kim, Sun Mee Yang, Moon Suk Nam, Hyoung Woo Lee, Ki Young Lee, Sihoon Lee, Yeun Sun Kim, Ie Byung Park
Diabetes Metab J. 2011;35(2):182-187.   Published online April 30, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.2.182
  • 8,309 View
  • 72 Download
  • 19 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

It is known that diabetes and stress are directly or indirectly related, and that it is important to evaluate stress in patients with diabetes. The relationship between Korean diabetics and diabetes-related stress has never been reported. The objective of this study was to develop a stress questionnaire suitable for use with Korean diabetics and to evaluate its utility.

Methods

This study subjects were 307 Korean diabetics, aged 40 to 74 years old, who visited the Department of Endocrinology and Metabolism at Gachon University Gil Hospital, Yeungnam University Medical Center, and Inha University Hospital in Korea between March 2006 and February 2008. We developed a Korean version of Polonsky's Problem Areas in Diabetes (PAID) stress questionnaire (PAID-K) and used it to assess degrees of stress in our sample of Korean patients. We evaluated the utility of the questionnaire and analyzed the relationships between clinical characteristics of the study subjects and degrees of stress.

Results

Cronbach's alpha for PAID-K was 0.95, and PAID-K scores were significantly correlated with Hypoglycemia Fear Survey scores (r=0.44, P<0.05) and State Trait Anxiety Inventory-6 scores (r=0.21, P<0.05). PAID-K scores were significantly higher in patients with longer durations of diabetes, patients using insulin, and female patients (P=0.02, P=0.038, and P=0.001, respectively). The score also tended to increase as HbA1c levels increased, except for very high HbA1c levels (above 11%) (P for trend<0.05).

Conclusion

We developed the PAID-K questionnaire and demonstrated its utility to evaluate levels of stress in diabetic patients in Korea.

Citations

Citations to this article as recorded by  
  • Associations Between Self‐Stigma and Health Promotion Behaviors in Overweight/Obese Patients With Type 2 Diabetes: A Cross‐Sectional Study
    Shilian Niu, Rao Li, Li Yuan, Dan Huang, Daniele Sola
    Journal of Diabetes Research.2025;[Epub]     CrossRef
  • Evaluating the efficacy and acceptability of a digital-based management system for diabetes during pregnancy: protocol for an observational cohort study
    Byung Soo Kang, Jin Yu, Kyuho Kim, Jae-Seung Yun, Youn Ju Lee, Hyun Sun Ko, Yoon-Hee Choi
    BMJ Open.2025; 15(6): e090775.     CrossRef
  • Emotional stress in older persons with type 2 diabetes mellitus in Brazilian primary health care centres: a cross-sectional study
    Nara Jacqueline Souza dos Santos, Kleiton Coelho Almeida, Leonardo Regis Leira Pereira, Pablo Maciel Moreira, Priscila Ribeiro Castro, Erlan Canguçu Aguiar, Marcio Galvão Oliveira
    Aging & Mental Health.2025; : 1.     CrossRef
  • Impact of diabetes distress on glycemic control and diabetic complications in type 2 diabetes mellitus
    Hye-Sun Park, Yongin Cho, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, Young Ju Suh, Suk Chon, Jeong-Taek Woo, Sei Hyun Baik, Kwan Woo Lee, So Hun Kim
    Scientific Reports.2024;[Epub]     CrossRef
  • Development and Validation of a Distress Measurement Related to Glucose Monitoring of Diabetes Patients
    Eujin Choi, Sooyeon Kim, Juhee Cho, Min-Sun Kim, Eun Kyung Kwon, Youngha Kim, Danbee Kang, Sung Yoon Cho
    Diabetes Therapy.2023; 14(4): 737.     CrossRef
  • Development and validation of a distress measurement for insulin injections among patients with diabetes
    Eujin Choi, Min-Sun Kim, Juhee Cho, Sooyeon Kim, Eun Kyung Kwon, Youngha Kim, Danbee Kang, Sung Yoon Cho
    Scientific Reports.2023;[Epub]     CrossRef
  • The Mediating Effect of Experiential Avoidance on the Relationship between Diabetes Distress and Self-Stigma in People with Diabetes Mellitus Type 2 in Republic of Korea
    Kawoun Seo
    Healthcare.2023; 11(20): 2773.     CrossRef
  • Patient-reported outcome measures for assessing health-related quality of life in people with type 2 diabetes: A systematic review
    Marlous Langendoen-Gort, Lenka Groeneveld, Cecilia A. C. Prinsen, Joline W. Beulens, Petra J. M. Elders, Ilana Halperin, Geetha Mukerji, Caroline B. Terwee, Femke Rutters
    Reviews in Endocrine and Metabolic Disorders.2022; 23(5): 931.     CrossRef
  • The Mediating Effect of Acceptance Action in the Relationship between Diabetes Distress and Self-stigma among Old Adults with Diabetes in South Korea
    Hyesun Kim, Kawoun Seo
    Journal of Korean Academy of Community Health Nursing.2022; 33(4): 446.     CrossRef
  • Mobile Healthcare System Provided by Primary Care Physicians Improves Quality of Diabetes Care
    Tae Jung Oh, Jie-Eun Lee, Seok Kim, Sooyoung Yoo, Hak Chul Jang
    CardioMetabolic Syndrome Journal.2021; 1(1): 88.     CrossRef
  • Measurement Properties of Patient-Reported Outcome Measures for Diabetes: Systematic Review
    Priscilla Jia Ling Wee, Yu Heng Kwan, Dionne Hui Fang Loh, Jie Kie Phang, Troy H Puar, Truls Østbye, Julian Thumboo, Sungwon Yoon, Lian Leng Low
    Journal of Medical Internet Research.2021; 23(8): e25002.     CrossRef
  • Validity and Reliability of the Korean Version of the Acceptance and Action Questionnaire-Stigma (AAQ-S-K)
    Hyunjin Lee, Myoungjin Kwon, Kawoun Seo
    Healthcare.2021; 9(10): 1355.     CrossRef
  • Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes
    Marko Grahovac, Marko Kumric, Marino Vilovic, Dinko Martinovic, Ante Kreso, Tina Ticinovic Kurir, Josip Vrdoljak, Karlo Prizmic, Joško Božić
    World Journal of Diabetes.2021; 12(11): 1942.     CrossRef
  • The Impact of a Community-Based Food Education Program on Nutrition-Related Knowledge in Middle-Aged and Older Patients with Type 2 Diabetes: Results of a Pilot Randomized Controlled Trial
    Carlos Vasconcelos, António Almeida, Maria Cabral, Elisabete Ramos, Romeu Mendes
    International Journal of Environmental Research and Public Health.2019; 16(13): 2403.     CrossRef
  • The Effects of the 2030 Diabetes Camp Program on Depression, Anxiety, and Stress in Diabetic Patients
    Jin Hee Jung, Jung Hwa Lee
    The Journal of Korean Diabetes.2019; 20(3): 194.     CrossRef
  • Research of Type 2 Diabetes Patients’ Problem Areas and Affecting Factors
    Sebahat Atalikoğlu Başkan, Mehtap Tan
    Journal of Diabetes Mellitus.2017; 07(03): 175.     CrossRef
  • Diabetes-related emotional distress instruments: A systematic review of measurement properties
    Jiyeon Lee, Eun-Hyun Lee, Chun-Ja Kim, Seung Hei Moon
    International Journal of Nursing Studies.2015; 52(12): 1868.     CrossRef
  • Internet-Based Mentoring Program for Patients with Type 1 Diabetes
    Sun-Hye Ko, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2014; 38(2): 107.     CrossRef
  • Influence of the Duration of Diabetes on the Outcome of a Diabetes Self-Management Education Program
    Seung-Hyun Ko, Sin-Ae Park, Jae-Hyoung Cho, Sun-Hye Ko, Kyung-Mi Shin, Seung-Hwan Lee, Ki-Ho Song, Yong-Moon Park, Yu-Bae Ahn
    Diabetes & Metabolism Journal.2012; 36(3): 222.     CrossRef
Association of Educational Level and Socioeconomic Status with Glucose Metabolism.
Young Sil Eom, Sun Mee Yang, Pyung Chun Oh, Jung Hyun Lee, Ki Young Lee, Yeun Sun Kim, Sihoon Lee, Jung Soo Im, Jun Yim, Dae Kyu Oh, Moon Suk Nam, Ie Byung Park
Korean Diabetes J. 2008;32(4):377-385.   Published online August 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.4.377
  • 3,667 View
  • 35 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
The objective of the present study was to examine the association of educational level and socioeconomic status with glucose metabolism including prediabetes. METHODS: This cross-sectional study subjects were 882 (mean age: 51.0 +/- 13.4 years, M:F = 241:641) without diabetes, aged more than 20 years and residing in Whasu 2 dong in Incheon. We classified them into three levels according to their educational level: primary (illiterate or up to elementary school), secondary (middle school or high school) and tertiary (university), and into three levels according to their socioeconomic status by self reported questionnaire: low, middle and high. Subjects were diagnosed as three groups (normal, prediabetes and diabetes) by American Diabetes Association criteria using 75 g oral glucose tolerance test. The association of educational level and socioeconomic status with glucose metabolism was analyzed. RESULTS: The number of normal group was 300 (34.0%), that of prediabetes was 470 (53.3%) and that of diabetes was 112 (12.7%). In women, the proportion of primary educational group was larger than that of secondary educational group in diabetes (Odds ratio [OR] = 1.88; 95% confidence interval [CI]: 1.01-3.51) and larger than that of tertiary educational group in prediabetes ([OR] = 2.00; [CI]: 1.06-3.78). But socioeconomic status did not have the statistical association with glucose metabolism in women. Also both educational level and socioeconomic status had no statistical association with glucose metabolism in men. CONCLUSIONS: The proportion of low educational level is larger in prediabetes and diabetes compared with normal group in women.

Citations

Citations to this article as recorded by  
  • How do life-course trajectories of socioeconomic position affect quality of life in patients with diabetes mellitus?
    Hye Ah Lee, Ko Eun Lee, Yool Won Jeong, Jaeseon Ryu, Minkyung Kim, Jung Won Min, Young Sun Hong, Kyunghee Jung-Choi, Hyesook Park
    Quality of Life Research.2014; 23(4): 1337.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP