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Increased Epicardial Adipose Tissue Thickness in Type 2 Diabetes Mellitus and Obesity
Do Kyeong Song, Young Sun Hong, Hyejin Lee, Jee-Young Oh, Yeon-Ah Sung, Yookyung Kim
Diabetes Metab J. 2015;39(5):405-413.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.405
  • 3,868 View
  • 62 Download
  • 53 Web of Science
  • 50 Crossref
AbstractAbstract PDFPubReader   
Background

Epicardial adipose tissue (EAT) is suggested to play an important role in the progression of metabolic syndrome. We aimed to establish a simple method to measure EAT and examine the differences in EAT thickness according to the presence of type 2 diabetes mellitus or obesity.

Methods

A total of 94 patients (42.6% type 2 diabetes mellitus, 53.2% obese, mean age 61±13) who underwent multidetector computed tomography were enrolled. Thickness of EAT was measured on the parasternal short and horizontal long axis view. Epicardial fat area (EFA) was measured at the level of left main coronary artery (LMCA).

Results

All EAT thicknesses were correlated with EFA at the LMCA level (r=0.235 to 0.613, all Ps<0.05), and EAT thickness in the left atrioventricular groove (LAVG) had the highest correlation coefficient (r=0.613). EFA, and EAT thicknesses in the LAVG and the left ventricular apex were higher in the group with type 2 diabetes mellitus than in the group without type 2 diabetes mellitus when adjusted only for body mass index. When adjusted only for type 2 diabetes mellitus, EFA, and EAT thicknesses in the LAVG and the right atrioventricular groove were higher in obese group than in nonobese group.

Conclusion

In conclusion, EAT thickness can be easily measured and represent EFA. EAT thickness, especially in LAVG, was higher in groups with type 2 diabetes mellitus and obesity independently. These findings implicate that EAT thickness may be a useful indicator for type 2 diabetes mellitus and obesity.

Citations

Citations to this article as recorded by  
  • Association of epicardial adipose tissue with early structural and functional cardiac changes in Type 2 diabetes
    Sarah L. Ayton, Jian L. Yeo, Gaurav S. Gulsin, Abhishek Dattani, Joanna Bilak, Aparna Deshpande, J. Ranjit Arnold, Anvesha Singh, Matthew P.M. Graham-Brown, Leong Ng, Donald Jones, Piotr Slomka, Damini Dey, Alastair J. Moss, Emer M. Brady, Gerry P. McCann
    European Journal of Radiology.2024; 174: 111400.     CrossRef
  • Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population - The Cardiovascular Risk in Young Finns Study
    Behnoush Gustafsson, Suvi P. Rovio, Saku Ruohonen, Nina Hutri-Kähönen, Mika Kähönen, Jorma S. A. Viikari, Katja Pahkala, Olli T. Raitakari
    Scientific Reports.2024;[Epub]     CrossRef
  • The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy
    Santosh K Sanganalmath, Shubham Dubey, Sudhakar Veeranki, Keerthy Narisetty, Prasanna Krishnamurthy
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • Potential impact of epicardial fat thickness, pentraxin-3, and high-sensitive C-reactive protein on the risk of non-proliferative diabetic retinopathy
    Mohammed Ali Gameil, Hanan Abdelhay Elsherbiny, Ibrahim Elsayed Youssry, Sara Abdel Gawad, Ahmed Abd EL-Hakim Arafat
    Journal of Diabetes & Metabolic Disorders.2023; 22(1): 735.     CrossRef
  • Echocardiographic evaluation of the effect of dapagliflozin on epicardial adipose tissue and left ventricular systolic function in type 2 diabetes mellitus
    Xiang-ting Song, Yu-long Wei, Yi-fei Rui, Li Fan
    Journal of Diabetes and its Complications.2023; 37(7): 108509.     CrossRef
  • Associations of aortic stiffness and intra-aortic flow parameters with epicardial adipose tissue in patients with type-2 diabetes
    Khaoula Bouazizi, Mohamed Zarai, Abdallah Noufaily, Mikaël Prigent, Thomas Dietenbeck, Emilie Bollache, Toan Nguyen, Valéria Della Valle, Eléonore Blondiaux, Karine Clément, Judith Aron-Wisnewsky, Fabrizio Andreelli, Alban Redheuil, Nadjia Kachenoura
    Frontiers in Clinical Diabetes and Healthcare.2023;[Epub]     CrossRef
  • Epicardial adipose tissue, metabolic disorders, and cardiovascular diseases: recent advances classified by research methodologies
    Yujie Song, Yanzhen Tan, Meng Deng, Wenju Shan, Wenying Zheng, Bing Zhang, Jun Cui, Lele Feng, Lei Shi, Miao Zhang, Yingying Liu, Yang Sun, Wei Yi
    MedComm.2023;[Epub]     CrossRef
  • Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
    Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(5): e1976.     CrossRef
  • Dysregulated Epicardial Adipose Tissue as a Risk Factor and Potential Therapeutic Target of Heart Failure with Preserved Ejection Fraction in Diabetes
    Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Luca Rinaldi, Francesca Coviello, Anna Di Martino, Gaetana Albanese, Sara Colantuoni, Giulia Medicamento, Raffaele Marfella, Celestino Sardu, Ferdinando Carlo Sasso
    Biomolecules.2022; 12(2): 176.     CrossRef
  • Surgically Metabolic Resection of Pericardial Fat to Ameliorate Myocardial Mitochondrial Dysfunction in Acute Myocardial Infarction Obese Rats
    Ki-Woon Kang, Ju-Young Ko, Hyunghee Lee, Seung Yong Shin, Wang Soo Lee, Joonhwa Hong, Sang-Wook Kim, Seong-Kyu Lee, Min-Ho Oak
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Inflammation and Cardiovascular Diseases in the Elderly: The Role of Epicardial Adipose Tissue
    Maddalena Conte, Laura Petraglia, Paolo Poggio, Vincenza Valerio, Serena Cabaro, Pasquale Campana, Giuseppe Comentale, Emilio Attena, Vincenzo Russo, Emanuele Pilato, Pietro Formisano, Dario Leosco, Valentina Parisi
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Increased fetal epicardial fat thickness: A reflecting finding for GDM and perinatal outcomes
    Cantekin Iskender, Kadriye Yakut Yücel, Murat Levent Dereli, Erkan Sağlam, Şevki Çelen, Turhan Çağlar, Yaprak Engin‐Üstün
    Echocardiography.2022; 39(8): 1082.     CrossRef
  • Epicardial Adipose Tissue: A Novel Potential Imaging Marker of Comorbidities Caused by Chronic Inflammation
    Maria Grazia Tarsitano, Carla Pandozzi, Giuseppe Muscogiuri, Sandro Sironi, Arturo Pujia, Andrea Lenzi, Elisa Giannetta
    Nutrients.2022; 14(14): 2926.     CrossRef
  • Correlation analysis of epicardial adipose tissue and ventricular myocardial strain in Chinese amateur marathoners using cardiac magnetic resonance
    Zirong Wang, Tingting Song, Da Yu, Xiaofei Chen, Cailing Pu, Jianping Ding, Xiaoli Ling, Chim C. Lang
    PLOS ONE.2022; 17(9): e0274533.     CrossRef
  • Is there a paradigm shift in preventing diabetic heart failure? A review of SGLT2 inhibitors
    Sumanth KHAKDE, Hafsa JAWAID, Farah YASMIN, Mashal BINTE ALI, Abdur REHMAN
    Minerva Endocrinology.2022;[Epub]     CrossRef
  • Effect of caloric restriction with or without physical activity on body composition and epicardial fat in type 2 diabetic patients: A pilot randomized controlled trial
    Josée Leroux-Stewart, Belinda Elisha, Sémah Tagougui, Corinne Suppère, Sophie Bernard, Hortensia Mircescu, Katherine Desjardin, Virginie Messier, Gianluca Iacobellis, Rémi Rabasa-Lhoret
    Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(3): 921.     CrossRef
  • Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation
    Vishal Vyas, Hazel Blythe, Elizabeth G. Wood, Balraj Sandhar, Shah-Jalal Sarker, Damian Balmforth, Shirish G. Ambekar, John Yap, Stephen J. Edmondson, Carmelo Di Salvo, Kit Wong, Neil Roberts, Rakesh Uppal, Ben Adams, Alex Shipolini, Aung Y. Oo, David Law
    JCI Insight.2021;[Epub]     CrossRef
  • Impact of diabetes on cardiopulmonary function: the added value of a combined cardiopulmonary and echocardiography stress test
    Nicola Riccardo Pugliese, Alessandra Pieroni, Nicolò De Biase, Valerio Di Fiore, Lorenzo Nesti, Piergiuseppe Agostoni, Frank Lloyd Dini
    Heart Failure Reviews.2021; 28(3): 645.     CrossRef
  • Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise
    Enrique Verdú, Judit Homs, Pere Boadas-Vaello
    International Journal of Environmental Research and Public Health.2021; 18(24): 13333.     CrossRef
  • Epicardial adipose tissue is tightly associated with exercise intolerance in patients with type 2 diabetes mellitus with asymptomatic left ventricular structural and functional abnormalities
    Yousuke Sugita, Katsuhiko Ito, Shigeki Sakurai, Satoshi Sakai, Shinya Kuno
    Journal of Diabetes and its Complications.2020; 34(5): 107552.     CrossRef
  • Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease
    Rim Rafeh, Anissa Viveiros, Gavin Y. Oudit, Ahmed F. El-Yazbi
    Clinical Science.2020; 134(7): 827.     CrossRef
  • High released lactate by epicardial fat from coronary artery disease patients is reduced by dapagliflozin treatment
    Marinela Couselo-Seijas, Rosa María Agra-Bermejo, Angel Luis Fernández, José Manuel Martínez-Cereijo, Juan Sierra, Maeve Soto-Pérez, Adriana Rozados-Luis, José Ramón González-Juanatey, Sonia Eiras
    Atherosclerosis.2020; 292: 60.     CrossRef
  • Echocardiography in the Era of Obesity
    Milad C. El Hajj, Sheldon E. Litwin
    Journal of the American Society of Echocardiography.2020; 33(7): 779.     CrossRef
  • Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes
    Eugene Han, Ji-Yeon Lee, Kyung-do Han, Hanna Cho, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Zobair M Younossi, Yong-ho Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Do most patients with obesity or type 2 diabetes, and atrial fibrillation, also have undiagnosed heart failure? A critical conceptual framework for understanding mechanisms and improving diagnosis and treatment
    Milton Packer
    European Journal of Heart Failure.2020; 22(2): 214.     CrossRef
  • Effect of liraglutide on epicardial adipose tissue thickness with echocardiography in patients with obese type 2 diabetes mellitus
    Ying Li, Xuewei Liu, Guangsen Li, Ping Zhang
    International Journal of Diabetes in Developing Countries.2020; 40(4): 500.     CrossRef
  • Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis
    Yingrui Li, Bin Liu, Yu Li, Xiaodong Jing, Songbai Deng, Yulin Yan, Qiang She
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • CoreSlicer: a web toolkit for analytic morphomics
    Louis Mullie, Jonathan Afilalo
    BMC Medical Imaging.2019;[Epub]     CrossRef
  • Critical role of the epicardium in mediating cardiac inflammation and fibrosis in patients with type 2 diabetes
    Milton Packer
    Diabetes, Obesity and Metabolism.2019; 21(8): 1765.     CrossRef
  • MRI-based assessment and characterization of epicardial and paracardial fat depots in the context of impaired glucose metabolism and subclinical left-ventricular alterations
    Sophia D Rado, Roberto Lorbeer, Sergios Gatidis, Jürgen Machann, Corinna Storz, Konstantin Nikolaou, Wolfgang Rathmann, Udo Hoffmann, Annette Peters, Fabian Bamberg, Christopher L Schlett
    The British Journal of Radiology.2019;[Epub]     CrossRef
  • Epicardial adipose tissue and cardiovascular diseases
    Anna Maria Ansaldo, Fabrizio Montecucco, Amirhossein Sahebkar, Franco Dallegri, Federico Carbone
    International Journal of Cardiology.2019; 278: 254.     CrossRef
  • Occurrence, mortality and predictors of complicated cardiac perforation in patients with CRT-D: Based on the National Inpatient Sample registry
    Hiro Kawata, Ashwini Erande, Ola Lafi, Ching Wei Chen, Taishi Hirai, Peter Santucci, Shaista Malik
    International Journal of Cardiology.2019; 293: 109.     CrossRef
  • Integration of Gene Expression Profile Data of Human Epicardial Adipose Tissue from Coronary Artery Disease to Verification of Hub Genes and Pathways
    Weitie Wang, Qing Liu, Yong Wang, Hulin Piao, Bo Li, Zhicheng Zhu, Dan Li, Tiance Wang, Rihao Xu, Kexiang Liu
    BioMed Research International.2019; 2019: 1.     CrossRef
  • The effect of dapagliflozin treatment on epicardial adipose tissue volume
    Takao Sato, Yoshifusa Aizawa, Sho Yuasa, Shohei Kishi, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Hitoshi Kitazawa, Minoru Takahashi, Masahito Sato, Masaaki Okabe
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium
    Milton Packer
    Journal of the American College of Cardiology.2018; 71(20): 2360.     CrossRef
  • Relationships between epicardial adipose tissue thickness and adipo-fibrokine indicator profiles post-myocardial infarction
    Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Daria Borodkina, Olga Akbasheva, Ekaterina Belik, Viktoria Karetnikova, Natalia Brel, Alexander Kokov, Vasiliy Kashtalap, Olga Barbarash
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications
    Milton Packer
    European Journal of Heart Failure.2018; 20(7): 1100.     CrossRef
  • Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
    Maria A. Pabon, Kevin Manocha, Jim W. Cheung, James C. Lo
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Leptin-Aldosterone-Neprilysin Axis
    Milton Packer
    Circulation.2018; 137(15): 1614.     CrossRef
  • Do DPP-4 Inhibitors Cause Heart Failure Events by Promoting Adrenergically Mediated Cardiotoxicity?
    Milton Packer
    Circulation Research.2018; 122(7): 928.     CrossRef
  • The epicardial adipose inflammatory triad: coronary atherosclerosis, atrial fibrillation, and heart failure with a preserved ejection fraction
    Milton Packer
    European Journal of Heart Failure.2018; 20(11): 1567.     CrossRef
  • Assessment of relationships between novel inflammatory markers and presence and severity of preeclampsia: Epicardial fat thickness, pentraxin-3, and neutrophil-to-lymphocyte ratio
    Huseyin Altug Cakmak, Burcu Dincgez Cakmak, Cigdem Abide Yayla, Ebru Inci Coskun, Mehmet Erturk, Ibrahim Keles
    Hypertension in Pregnancy.2017; 36(3): 233.     CrossRef
  • Sexual dimorphism in obesity-related genes in the epicardial fat during aging
    Caitlin Kocher, Matthew Christiansen, Sarah Martin, Christopher Adams, Paulette Wehner, Todd Gress, Nalini Santanam
    Journal of Physiology and Biochemistry.2017; 73(2): 215.     CrossRef
  • Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008–2011)
    Eugene Han, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, In-Kyu Lee, Bong-Soo Cha
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes: a pilot study
    Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study
    Asli Akin Belli, Ilknur Altun, Ibrahim Altun
    Anais Brasileiros de Dermatologia.2017; 92(6): 820.     CrossRef
  • Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches?
    Katja Rietdorf, Hilary MacQueen
    British Journal of Pharmacology.2017; 174(20): 3542.     CrossRef
  • Impact of Mediterranean diet on metabolic syndrome, cancer and longevity
    Nicola Di Daniele, Annalisa Noce, Maria Francesca Vidiri, Eleonora Moriconi, Giulia Marrone, Margherita Annicchiarico-Petruzzelli, Gabriele D’Urso, Manfredi Tesauro, Valentina Rovella, Antonino De Lorenzo
    Oncotarget.2017; 8(5): 8947.     CrossRef
  • Role of miRNAs in Epicardial Adipose Tissue in CAD Patients with T2DM
    Yang Liu, Wenbo Fu, Mu Lu, Shitao Huai, Yaqin Song, Yutao Wei
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity
    S. Mariani, D. Costantini, C. Lubrano, S. Basciani, C. Caldaroni, G. Barbaro, E. Poggiogalle, L.M. Donini, A. Lenzi, L. Gnessi
    Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(11): 1033.     CrossRef
FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women
Do Kyeong Song, Hyejin Lee, Jee-Young Oh, Young Sun Hong, Yeon-Ah Sung
Diabetes Metab J. 2014;38(4):302-310.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.302
  • 4,122 View
  • 44 Download
  • 25 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   
Background

The fat mass and obesity-associated (FTO) gene is associated with obesity and type 2 diabetes mellitus. Obesity and insulin resistance are also common features of polycystic ovary syndrome (PCOS). Therefore, the FTO gene might be a candidate gene for PCOS susceptibility. The aim of the present study was to evaluate the effects of FTO gene variants on PCOS susceptibility and metabolic and reproductive hormonal parameters.

Methods

We recruited 432 women with PCOS (24±5 years) and 927 healthy women with regular menstrual cycles (27±5 years) and performed a case-control association study. We genotyped the single nucleotide polymorphisms rs1421085, rs17817449, and rs8050136 in the FTO gene and collected metabolic and hormonal measurements.

Results

Logistic regression revealed that the G/G genotype (rs1421085, 1.6%), the C/C genotype (rs17817449, 1.6%), and the A/A genotype (rs8050136, 1.6%) were strongly associated with an increased risk of PCOS (odds ratio, 2.551 to 2.559; all P<0.05). The strengths of these associations were attenuated after adjusting for age and BMI. The women with these genotypes were more obese and exhibited higher free androgen indices (P<0.05) and higher free testosterone levels (P=0.053 to 0.063) compared to the other genotypes. However the significant differences disappeared after adjusting for body mass index (BMI). When we analyzed the women with PCOS and the control groups separately, there were no significant differences in the metabolic and reproductive hormonal parameters according to the FTO gene variants.

Conclusion

The rs1421085, rs17817449, and rs8050136 variants of the FTO gene were associated with PCOS susceptibility and hyperandrogenemia in young Korean women. These associations may be mediated through an effect of BMI.

Citations

Citations to this article as recorded by  
  • Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
    Prakash Patil, Neevan D'Souza, Sudeep D. Ghate, Lakshmi Nagendra, Harish B. Girijashankar
    Journal of Health and Allied Sciences NU.2023; 13(03): 380.     CrossRef
  • Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS
    Wassim Y. Almawi, Rita Nemr, Tomiris Atazhanova, Zainab H. Malalla, Sameh Sarray, Fekria E. Mustafa, Naeema A. Mahmood
    Reproductive Sciences.2023; 30(7): 2166.     CrossRef
  • FTO: a critical role in obesity and obesity-related diseases
    Dan Yin, Yiyang Li, Xingyue Liao, Dewei Tian, Yunsi Xu, Cuilan Zhou, Jun Liu, Suyun Li, Jing Zhou, Yulin Nie, Hongqing Liao, Cuiying Peng
    British Journal of Nutrition.2023; 130(10): 1657.     CrossRef
  • Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India
    Hiral Chaudhary, Jalpa Patel, Nayan K. Jain, Sonal Panchal, Naresh Laddha, Rushikesh Joshi
    BMC Medical Genomics.2023;[Epub]     CrossRef
  • ASSOCIATION BETWEEN FAT MASS AND OBESITY ASSOCIATED (FTO) RS17817449 GENE POLYMORPHISM WITH INSULIN RESISTANCE AND OBESITY IN THE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
    Mahbobeh Moayeri, Masoumeh Nezhadali, Mahnaz Mohamadi
    Studies in Medical Sciences.2023; 33(12): 868.     CrossRef
  • Association of FTO gene variants rs9939609 and rs1421085 with polycystic ovary syndrome
    Alaa A. Alnafjan, Afrah F. Alkhuriji, Hussah M. Alobaid, Zainb A. Babay, Mahmoud I. Khalil
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • Association of FTO gene variant rs9939609 with hyperandrogenemia and fasting glucose levels in South Indian women with polycystic ovarian syndrome
    Zeinab Naghshband, Suttur S. Malini
    Egyptian Journal of Medical Human Genetics.2022;[Epub]     CrossRef
  • Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome
    Giorgia Scarfò, Simona Daniele, Jonathan Fusi, Marco Gesi, Claudia Martini, Ferdinando Franzoni, Vito Cela, Paolo Giovanni Artini
    Biomedicines.2022; 10(6): 1305.     CrossRef
  • Fat mass and Obesity Associated (FTO) gene and polycystic ovary syndrome: Insight into pathogenesis and association with insulin resistance
    Sadaf Parveen, Saba Khan, Haseeb Ahsan, Priyanka Thapa Manger, Bhavana Gupta, Roshan Alam
    Human Nutrition & Metabolism.2022; 30: 200174.     CrossRef
  • Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
    Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi, Mehdi Moradinazar
    Genes & Nutrition.2022;[Epub]     CrossRef
  • In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study
    Umayal Branavan, Sulochana Wijesundera, Vishvanath Chandrasekaran, Carukshi Arambepola, Chandrika Wijeyaratne
    BMC Medical Genetics.2020;[Epub]     CrossRef
  • Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study
    Yalin Zhao, Yuping Xu, Xiaomeng Wang, Lin Xu, Jianhua Chen, Chengwen Gao, Chuanhong Wu, Dun Pan, Qian Zhang, Juan Zhou, Ruirui Chen, Zhuo Wang, Han Zhao, Li You, Yunxia Cao, Zhiqiang Li, Yongyong Shi
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(6): 1778.     CrossRef
  • Polikistik Over Sendromu ve Obezite: FTO ve MC4R Gen Polimorfizmlerinin Rolü
    Ayçıl ÖZTURAN ŞİRİN, Yasemin AKDEVELİOĞLU
    Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi.2020; 4(3): 275.     CrossRef
  • Vitamin D receptor and binding protein polymorphisms in women with polycystic ovary syndrome: a case control study
    Do Kyeong Song, Hyejin Lee, Young Sun Hong, Yeon-Ah Sung
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences
    Jin Ju Kim, Young Min Choi
    Journal of Obstetrics and Gynaecology Research.2019; 45(12): 2330.     CrossRef
  • Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis
    Ritu Deswal, Arun Yadav, Amita Suneja Dang
    Systems Biology in Reproductive Medicine.2018; 64(1): 12.     CrossRef
  • Association between FTO gene polymorphisms and type 2 diabetes mellitus, serum levels of apelin and androgen hormones among Iranian obese women
    Farzaneh Ghafarian-Alipour, Shayan Ziaee, Mohamad Reza Ashoori, Mir Saeid Zakeri, Mohammad Ali Boroumand, Naser Aghamohammadzadeh, Maryam Abbasi-Majdi, Fatemeh Shool, Navid Sarakhs Asbaghi, Abolghasem Mohammadi, Nosratollah Zarghami
    Gene.2018; 641: 361.     CrossRef
  • The role of FTO variants in the susceptibility of polycystic ovary syndrome and in vitro fertilization outcomes in Chinese women
    Ai Ling Liu, Hong Qing Liao, Jing Zhou, Yu Lin Nie, Cui Lan Zhou, Zhi Liang Li, Zi Fen Guo, Dong Xiu He, Yun Hua Zhu, Cui Ying Peng
    Gynecological Endocrinology.2018; 34(8): 719.     CrossRef
  • Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
    Joel Eriksson, Robin Haring, Niels Grarup, Liesbeth Vandenput, Henri Wallaschofski, Erik Lorentzen, Torben Hansen, Dan Mellström, Oluf Pedersen, Matthias Nauck, Mattias Lorentzon, Lise Lotte Nystrup Husemoen, Henry Völzke, Magnus Karlsson, Sebastian E. Ba
    PLOS ONE.2017; 12(4): e0176277.     CrossRef
  • Post-transcriptional gene regulation by mRNA modifications
    Boxuan Simen Zhao, Ian A. Roundtree, Chuan He
    Nature Reviews Molecular Cell Biology.2017; 18(1): 31.     CrossRef
  • The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
    Do Kyeong Song, Yeon-Ah Sung, Hyejin Lee, Wan-Xi Yang
    PLOS ONE.2016; 11(9): e0163756.     CrossRef
  • Haplotyping strategy highlights the specificity of FTO gene association with polycystic ovary syndrome in Tunisian women population
    Assila Ben Salem, Redha Attaoua, Nabil Mtiraoui, Sawssen Meddeb, Olfa Kacem, Mounir Ajina, Moncef Souissi, Patrick Poucheret, Christophe Normand, Touhami Mahjoub, Florin Grigorescu
    Gene.2015; 565(2): 166.     CrossRef
  • FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil
    Ramon B. Ramos, Poli Mara Spritzer
    Gene.2015; 560(1): 25.     CrossRef
  • Interaction between common variants of FTO and MC4R is associated with risk of PCOS
    Huiqin Yuan, Guoping Zhu, Fang Wang, Xiang Wang, Huihui Guo, Mo Shen
    Reproductive Biology and Endocrinology.2015;[Epub]     CrossRef
Long Menstrual Cycle Is Associated with Type 2 Diabetes Mellitus in Korean Women
Unjin Shim, Jee-Young Oh, Hye Jin Lee, Young Sun Hong, Yeon-Ah Sung
Diabetes Metab J. 2011;35(4):384-389.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.384
  • 30,184 View
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AbstractAbstract PDFPubReader   
Background

Long menstrual cycle is a risk factor for developing type 2 diabetes and cardiovascular disease in women. We aimed to evaluate the association between existing type 2 diabetes and oligomenorrhea before diagnosis of diabetes, and to observe the differences in this association among obese and non-obese Korean women.

Methods

Patients with type 2 diabetes (n=118) and without any clinical evidence of abnormal glucose regulation (n=258) who attended the outpatient clinic of a university hospital and were over age 30. Patients self-reporting a menstrual cycle over 40 days during their 20s were defined as oligomenorrhea before diagnosis of diabetes. Obesity was defined as having a body mass index (BMI) over 25 kg/m2.

Results

The frequency of oligomenorrhea before diagnosis of diabetes was almost two-fold higher in women with type 2 diabetes than in the control group (16.1% vs. 8.5%, P=0.03). Oligomenorrhea was associated with type 2 diabetes after adjusting for age, BMI, systolic blood pressure, triglycerides, and high density lipoprotein cholesterol (odds ratio, 3.89; 95% confidence interval, 1.37 to 11.04). Among women with oligomenorrhea before diagnosis of diabetes, the frequency of type 2 diabetes was significantly higher in obese subjects than in their non-obese counterparts (90.9% vs. 30.0%, P=0.03).

Conclusion

Having a long menstrual cycle could be a risk factor for the development of type 2 diabetes, especially in obese women.

Citations

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  • Fertility outcomes in women with pre-existing type 2 diabetes—a prospective cohort study
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  • The Menstrual Disturbances in Endocrine Disorders: A Narrative Review
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  • Reproductive health in women with type 2 diabetes mellitus
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  • Menstrual and reproductive factors and type 2 diabetes risk: The Japan Public Health Center‐based Prospective Study
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    Journal of Diabetes Investigation.2019; 10(1): 147.     CrossRef
  • Does Chronic Hyperglycemia Affect Female Rat Sexual Behavior? Differences in Paced and Non-Paced Mating
    Abigail K. Hernández-Munive, Daniela Rebolledo-Solleiro, Alonso Fernández-Guasti
    The Journal of Sexual Medicine.2019; 16(8): 1130.     CrossRef
  • Clinical implications of menstrual cycle length in oligomenorrhoeic young women
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    Clinical Endocrinology.2014; 80(1): 115.     CrossRef
  • The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome
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    Obesity.2013; 21(8): 1690.     CrossRef
  • Diabetes in women – A life-course approach
    Joanne R Morling, Beverley Balkau, Sarah H Wild
    Menopause International.2013; 19(2): 87.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
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