Diabetes & Metabolism Journal

Original Article

Metabolic Risk/Epidemiology
Iron Overload and the Risk of Diabetes in the General Population: Results of the Chinese Health and Nutrition Survey Cohort Study: He Gao, Jinying Yang, Wenfei Pan, Min Yang; Diabetes Metab J. 2022;46(2):307-318. Published online March 7, 2022; DOI: https://doi.org/10.4093/dmj.2020.0287

6,114 View
226 Download
17 Web of Science
17 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Recent studies have found that there are significant associations between body iron status and the development of diabetes. In the present study, we aimed to analyze the association among iron overload (IO), insulin resistance (IR), and diabetes in Chinese adults, and to explore the sex difference.
Methods
Men and women (age >19 years) who participated in the Chinese Health and Nutrition Survey and did not have diabetes at baseline were followed between 2009 and 2015 (n=5,779). Over a mean of 6 years, 75 participants were diagnosed with incident diabetes. Logistic regression was used to assess the risk factors associated with IO. Cox proportional hazard regression was used to estimate the risk of incident diabetes and to determine whether the risk differed among subgroups. Causal mediation analysis (CMA) was used to explore the mechanism linking IO and diabetes.
Results
According to sex-stratified multivariable-adjusted Cox proportional hazards regression, IO increased the risk of incident diabetes. Women with IO had a higher risk of diabetes than men. Subgroup analysis with respect to age showed that the association between IO and diabetes was stronger in older women and younger men (P<0.001). CMA showed that liver injury (alanine transaminase) and lipid metabolism abnormalities (triglyceride, apolipoprotein B) contributed to the association between IO and diabetes.
Conclusion
IO is associated with diabetes and this association is sex-specific. IO may indirectly induce IR via liver injury and lipid metabolism abnormalities, resulting in diabetes.

Citations

Citations to this article as recorded by

Micronutrient Patterns and Low Intake of Vitamin A, Vitamin D, Folate, Magnesium, and Potassium Among Prediabetes and Type 2 Diabetes Patients
Oana C Iatcu, Andrei Lobiuc, Mihai Covasa
Cureus.2024;[Epub] CrossRef
The levels, single and multiple health risk assessment of 23 metals in enteral nutrition formulas
Burhan Basaran, Hulya Turk
Food and Chemical Toxicology.2024; 192: 114914. CrossRef
Quantitative susceptibility mapping for iron monitoring of multiple subcortical nuclei in type 2 diabetes mellitus: a systematic review and meta-analysis
Sana Mohammadi, Sadegh Ghaderi, Fatemeh Sayehmiri, Mobina Fathi
Frontiers in Endocrinology.2024;[Epub] CrossRef
Iron Overload Induces Hepatic Ferroptosis and Insulin Resistance by Inhibiting the Jak2/stat3/slc7a11 Signaling Pathway
Manqiu Mo, Ling Pan, Ling Deng, Min Liang, Ning Xia, Yuzhen Liang
Cell Biochemistry and Biophysics.2024; 82(3): 2079. CrossRef
Diatom Chaetoceros Sp. as an Efficient Biological Antidote in Iron Toxicity: In‐Vitro and In‐Vivo Experiments
Zeinab Janahmadi, Shadi Talebi, Fatemeh Farjadian, Safieh Momeni
ChemistrySelect.2024;[Epub] CrossRef
Endogenous iron biomineralization in the mouse spleen of metabolic diseases
Ruowen Guo, Lei Zhang, Dongsheng Song, Biao Yu, Chao Song, Hanxiao Chen, Wenjing Xie, Chuanlin Feng, Guofeng Cheng, Kejun Hu, Jialiang Jiang, Zhe Qu, Haifeng Du, Xin Zhang
Fundamental Research.2024;[Epub] CrossRef
Plasma Ferritin Concentrations in the General Population: A Cross-Sectional Analysis of Anthropometric, Metabolic, and Dietary Correlates
Cara Övermöhle, Sabina Waniek, Gerald Rimbach, Katharina Susanne Weber, Wolfgang Lieb
The Journal of Nutrition.2023; 153(5): 1524. CrossRef
Association of Body Iron Metabolism with Type 2 Diabetes Mellitus in Chinese Women of Childbearing Age: Results from the China Adult Chronic Disease and Nutrition Surveillance (2015)
Jie Feng, Xiaoyun Shan, Lijuan Wang, Jiaxi Lu, Yang Cao, Lichen Yang
Nutrients.2023; 15(8): 1935. CrossRef
Iron overload induces islet β cell ferroptosis by activating ASK1/P-P38/CHOP signaling pathway
Ling Deng, Man-Qiu Mo, Jinling Zhong, Zhengming Li, Guoqiao Li, Yuzhen Liang
PeerJ.2023; 11: e15206. CrossRef
The role of ferroptosis in metabolic diseases
Ling Xie, Bin Fang, Chun Zhang
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2023; 1870(6): 119480. CrossRef
Epidemiological and transcriptome data identify potential key genes involved in iron overload for type 2 diabetes
Xuekui Liu, Xiu Hong, Shiqiang Jiang, Rui Li, Qian Lv, Jie Wang, Xiuli Wang, Manqing Yang, Houfa Geng, Yang Li
Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef
Association between serum iron and liver transaminases based on a large adult women population
Andong He, Zhuoping Zhou, Lili Huang, Ka Cheuk Yip, Jing Chen, Ruiling Yan, Ruiman Li
Journal of Health, Population and Nutrition.2023;[Epub] CrossRef
Association between serum ferritin and uric acid levels and nonalcoholic fatty liver disease in the Chinese population
Fangli Zhou, Xiaoli He, Dan Liu, Yan Ye, Haoming Tian, Li Tian
PeerJ.2023; 11: e16267. CrossRef
The Role of Iron Overload in Diabetic Cognitive Impairment: A Review
Ji-Ren An, Qing-Feng Wang, Gui-Yan Sun, Jia-Nan Su, Jun-Tong Liu, Chi Zhang, Li Wang, Dan Teng, Yu-Feng Yang, Yan Shi
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3235. CrossRef
The Association Between METS-IR and Serum Ferritin Level in United States Female: A Cross-Sectional Study Based on NHANES
Han Hao, Yan Chen, Ji Xiaojuan, Zhang Siqi, Chu Hailiang, Sun Xiaoxing, Wang Qikai, Xing Mingquan, Feng Jiangzhou, Ge Hongfeng
Frontiers in Medicine.2022;[Epub] CrossRef
Research Progress on Relationship Between Iron Overload and Lower Limb Arterial Disease in Type 2 Diabetes Mellitus
Zhongjing Wang, Shu Fang, Sheng Ding, Qin Tan, Xuyan Zhang
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 2259. CrossRef
Iron deficiency in cardiac surgical patients
L Hof, O Old, A.U. Steinbicker, P Meybohm, S Choorapoikayil, K Zacharowski
Acta Anaesthesiologica Belgica.2022; 73(4): 235. CrossRef

First
Prev
Page of 1
Next
Last

Search