Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal



Page Path
HOME > Search
2 "Wei Wang"
Article category
Publication year
Funded articles
Original Articles
Basic Research
Article image
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes
Junfei Gu, Jiajia Jin, Xiaoyu Ren, Xinjie Zhang, Jiaxuan Li, Xiaowei Wang, Shucui Zhang, Xianlun Yin, Qunye Zhang, Zhe Wang
Received August 16, 2023  Accepted February 7, 2024  Published online May 29, 2024  
DOI:    [Epub ahead of print]
  • 692 View
  • 28 Download
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Metabolic dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), in which the abnormalities in brown adipose tissue (BAT) play important roles. However, the cellular composition and function of BAT as well as its pathological significance in diabetes remain incompletely understood. Our objective is to delineate the single-cell landscape of BAT-derived stromal vascular fraction (SVF) and their characteristic alterations in T2DM rats.
T2DM was induced in rats by intraperitoneal injection of low-dose streptozotocin and high-fat diet feeding. Single-cell mRNA sequencing was then performed on BAT samples and compared to normal rats to characterize changes in T2DM rats. Subsequently, the importance of key cell subsets in T2DM was elucidated using various functional studies.
Almost all cell types in the BAT-derived SVF of T2DM rats exhibited enhanced inflammatory responses, increased angiogenesis, and disordered glucose and lipid metabolism. The multidirectional differentiation potential of adipose tissue-derived stem cells was also reduced. Moreover, macrophages played a pivotal role in intercellular crosstalk of BAT-derived SVF. A novel Rarres2+macrophage subset promoted the differentiation and metabolic function of brown adipocytes via adipose-immune crosstalk.
BAT SVF exhibited strong heterogeneity in cellular composition and function and contributed to T2DM as a significant inflammation source, in which a novel macrophage subset was identified that can promote brown adipocyte function.
Basic Research
Combination of Probiotics and Salvia miltiorrhiza Polysaccharide Alleviates Hepatic Steatosis via Gut Microbiota Modulation and Insulin Resistance Improvement in High Fat-Induced NAFLD Mice
Wei Wang, Ai-Lei Xu, Zheng-Chao Li, Yi Li, Shun-Fu Xu, Hua-Chao Sang, Fachao Zhi
Diabetes Metab J. 2020;44(2):336-348.   Published online December 3, 2019
  • 11,176 View
  • 307 Download
  • 64 Web of Science
  • 65 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   

Nonalcoholic fatty liver disease (NAFLD) increases the risk of hepatocellular carcinoma, which is currently the leading cause of obesity-related cancer deaths in middle-aged men.


Probiotics with lipid-lowering function were screened from the fecal microbiota of healthy adults. Polysaccharide from different sources was screened for improving insulin resistance. The combination of probiotics and Salvia miltiorrhiza polysaccharide (LBM) was investigated for alleviating hepatic steatosis.


First, Bifidobacterium bifidum V (BbV) and Lactobacillus plantarum X (LpX) were obtained from the fecal microbiota of healthy adults. Second, to improve insulin resistance, a Salvia miltiorrhiza Bunge polysaccharide showing good performance in reducing insulin resistance was obtained. The liver total cholesterol (TC) and total triglyceride (TG) levels and the serum levels of free fatty acid, alanine transaminase, aspartate transaminase, low density lipoprotein cholesterol, TG, and TC can be significantly reduced through supplementation with LpX-BbV (LB) in NAFLD mice. Interestingly, the function of the probiotic LB can be enhanced by S. miltiorrhiza Bunge polysaccharide. Furthermore, the gut microbiota was modulated by LpX-BbV+S. miltiorrhiza Bunge polysaccharide (LBM). The lipopolysaccharide concentration of the LBM group was decreased by 73.6% compared to the NAFLD group. Ultimately, the mRNA concentrations of the proinflammatory cytokines (tumor necrosis factor α, interleukin 1β [IL-1β], and IL-6) decreased with LB and LBM treatment.


The results of this this study indicate that the LBM combination can be used as a therapeutic for ameliorating NAFLD via modulating the gut microbiota and improving insulin resistance.


Citations to this article as recorded by  
  • Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway
    Guangkui Bu, Gang Chen, Juan Li, Dan Wu, Jiangtao Liao
    Journal of Investigative Medicine.2024; 72(1): 67.     CrossRef
  • Docosahexaenoic acid (DHA) alleviates hepatic lipid accumulation by regulating mitochondrial quality control through ERK signaling pathway in grass carp (Ctenopharyngodon idellus)
    Chenchen Bian, Shanghong Ji, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
    Aquaculture.2024; 579: 740209.     CrossRef
  • Association of lipid-lowering drugs with gut microbiota: a Mendelian randomization study
    Lubo Shi, Xiaoduo Liu, Enze Li, Shutian Zhang, Anni Zhou
    Journal of Clinical Lipidology.2024;[Epub]     CrossRef
  • Microbial-Based Bioactive Compounds to Alleviate Inflammation in Obesity
    Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor
    Current Issues in Molecular Biology.2024; 46(3): 1810.     CrossRef
  • Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives
    Qingyi Mao, Beibei Lin, Wenluo Zhang, Yu Zhang, Yu Zhang, Qian Cao, Mengque Xu
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Smilax China L. polysaccharide prevents HFD induced-NAFLD by regulating hepatic fat metabolism and gut microbiota
    Wenkai Zhang, Longhui Yu, Qinru Yang, Jinfeng Zhang, Wenjing Wang, Xinru Hu, Jingen Li, Guodong Zheng
    Phytomedicine.2024; 127: 155478.     CrossRef
  • Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)
    Raquel Benedé-Ubieto, Francisco Javier Cubero, Yulia A. Nevzorova
    Gut Microbes.2024;[Epub]     CrossRef
  • Prospect of research on anti-atherosclerosis effect of main components of traditional Chinese medicine Yiqi Huoxue Huatan recipe through gut microbiota: A review
    Hongtao Huang, Hanjun Zhao, Lv Wenqing, Feiyue Xu, Xiaolong Wang, Yili Yao, Yu Huang
    Medicine.2024; 103(5): e37104.     CrossRef
  • Polysaccharides from Eucommia ulmoides Oliv. Leaves Alleviate Acute Alcoholic Liver Injury by Modulating the Microbiota–Gut–Liver Axis in Mice
    Yingzhi Li, Huimei Wang, Xueping Leng, Jiaming Gao, Chang Li, Danfei Huang
    Foods.2024; 13(7): 1089.     CrossRef
  • Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
    Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang
    British Journal of Pharmacology.2024;[Epub]     CrossRef
  • Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites
    Dongliang Chen, Yuanfei Wang, Jianmei Yang, Wanyi Ou, Guiru Lin, Ze Zeng, Xiaomin Lu, Zumin Chen, Lili Zou, Yaling Tian, Aiping Wu, Shelley E. Keating, Qinhe Yang, Chenli Lin, Yinji Liang
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut–liver axis
    Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang
    Critical Reviews in Food Science and Nutrition.2023; 63(12): 1689.     CrossRef
  • Epigenetic compounds targeting pharmacological target lysine specific demethylase 1 and its impact on immunotherapy, chemotherapy and radiotherapy for treatment of tumor recurrence and resistance
    Clement Agboyibor, Jianshu Dong, Clement Yaw Effah, Emmanuel Kwateng Drokow, Maxwell Ampomah-Wireko, Waqar Pervaiz, Augustina Sangmor, Xinli Ma, Jian Li, Hong-Min Liu, Peng Zhang
    Biomedicine & Pharmacotherapy.2023; 157: 113934.     CrossRef
  • Salvia miltiorrhiza polysaccharides alleviate florfenicol-induced inflammation and oxidative stress in chick livers by regulating phagosome signaling pathway
    Xiao Wang, Wei Liu, Di Zhang, Yulan Jiao, Qianhui Zhao, Ying Liu, Wanyu Shi, Yongzhan Bao
    Ecotoxicology and Environmental Safety.2023; 249: 114428.     CrossRef
  • Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review
    Yuanyuan Li, Xin Zhang, Yining Li, Pei Yang, Zhiyuan Zhang, Hang Wu, Lihao Zhu, Yuhong Liu
    Journal of Ethnopharmacology.2023; 305: 116090.     CrossRef
  • The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial
    Dengcheng Hui, Lu Liu, Nisma Lena Bahaji Azami, Jingru Song, Yanping Huang, Wan Xu, Chao Wu, Dong Xie, Yulang Jiang, Yanqin Bian, Mingyu Sun
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The gut microbiota: A new perspective for tertiary prevention of hepatobiliary and gallbladder diseases
    Xiaoyu Huang, Yi Yang, Xueli Li, Xiaoya Zhu, Dan Lin, Yueran Ma, Min Zhou, Xiangyi Cui, Bingyu Zhang, Dongmei Dang, Yuhong Lü, Changwu Yue
    Frontiers in Nutrition.2023;[Epub]     CrossRef
  • Polysaccharides from Ostrea rivularis rebuild the balance of gut microbiota to ameliorate non-alcoholic fatty liver disease in ApoE−/− mice
    Lijun Zhu, Mingmei Xiao, Jigang Luo, Shijie Li, Wenting Liu, Jinchuan Wu, Zhuoyue Song
    International Journal of Biological Macromolecules.2023; 235: 123853.     CrossRef
  • Improvement of Inflammation, Diabetes, and Obesity by Forest Product-Derived Polysaccharides through the Human Intestinal Microbiota
    Seong-woo MYEONG, Yong Ju LEE, Do Hyun KIM, Tae-Jong KIM
    Journal of the Korean Wood Science and Technology.2023; 51(5): 358.     CrossRef
  • Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities
    Lei Luo, Juan Xue, Zheng Shao, Zhang Zhou, Wenqian Tang, Jinxin Liu, Hongfei Hu, Fan Yang
    Frontiers in Pharmacology.2023;[Epub]     CrossRef
  • In Vitro Probiotic Properties of Bifidobacterium animalis subsp. lactis SF and Its Alleviating Effect on Non-Alcoholic Fatty Liver Disease
    Huihui Lv, Feiyue Tao, Lingling Peng, Shufang Chen, Zhongyue Ren, Jiahui Chen, Bo Yu, Hua Wei, Cuixiang Wan
    Nutrients.2023; 15(6): 1355.     CrossRef
  • Ginsenoside Rg1 Ameliorates Pancreatic Injuries via the AMPK/mTOR Pathway in vivo and in vitro
    Jin Chen, Guoping Zhu, Wenbo Xiao, Xiaosong Huang, Kewu Wang, Yi Zong
    Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 779.     CrossRef
  • Managing metabolic diseases: The roles and therapeutic prospects of herb-derived polysaccharides
    Xinmei Xu, Lijie Wang, Kun Zhang, Yi Zhang, Gang Fan
    Biomedicine & Pharmacotherapy.2023; 161: 114538.     CrossRef
  • Probio-X Relieves Symptoms of Hyperlipidemia by Regulating Patients’ Gut Microbiome, Blood Lipid Metabolism, and Lifestyle Habits
    Huan Wang, Cuicui Ma, Yan Li, Lei Zhang, lima A, Chengcong Yang, Feiyan Zhao, Haifeng Han, Dongyang Shang, Fan Yang, Yuying Zhang, Heping Zhang, Zhihong Sun, Ruifang Guo, Yuan Pin Hung
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Sea cucumber sulfated polysaccharides and Lactobacillus gasseri synergistically ameliorate the overweight induced by altered gut microbiota in mice
    Zhengqi Liu, Chunqing Ai, Xinping Lin, Xiaoming Guo, Shuang Song, Beiwei Zhu
    Food & Function.2023; 14(9): 4106.     CrossRef
  • Supplementation of Lactobacillus plantarum ATCC14917 mitigates non-alcoholic fatty liver disease in high-fat-diet-fed rats
    Xingjian Wen, Hejing Liu, Xiaoling Luo, Li Lui, Jiuyu Fan, Yajing Xing, Jia Wang, Xingfang Qiao, Na Li, Guixue Wang
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine
    Ling Ye, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang, Huichang Bi
    Acta Pharmaceutica Sinica B.2023; 13(9): 3598.     CrossRef
  • α‐Lactalbumin Peptide Asp‐Gln‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα Pathway
    Haoran Chen, Yanfeng Ma, Xiaofen Qi, Jianjun Tian, Ying Ma, Tianjiao Niu
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5′‐monophosphate‐activated protein kinase pathway and reshaping gut microbiota
    Chao Han, Zongshuo Li, Ruiying Liu, Zihan Zhao, Yu Wang, Xuli Zuo, Yushi Zhang, Zeyu Geng, Houyu Huang, Xiuzhen Pan, Weidong Li
    Journal of the Science of Food and Agriculture.2023; 103(15): 7721.     CrossRef
  • Polysaccharides: The Potential Prebiotics for Metabolic Associated Fatty Liver Disease (MAFLD)
    Qin Guo, Yun Li, Xin Dai, Bangmao Wang, Jie Zhang, Hailong Cao
    Nutrients.2023; 15(17): 3722.     CrossRef
  • Prebiotics and Probiotics: Therapeutic Tools for Nonalcoholic Fatty Liver Disease
    Alejandra Mijangos-Trejo, Natalia Nuño-Lambarri, Varenka Barbero-Becerra, Misael Uribe-Esquivel, Paulina Vidal-Cevallos, Norberto Chávez-Tapia
    International Journal of Molecular Sciences.2023; 24(19): 14918.     CrossRef
  • Repair Effect and Mechanism of Electrospinning Nanocomposite Material with Gelatin-Bletilla Striata Gum/Salvia Miltiorrhiza on Orthopedic Refractory Wounds
    Geliang Hu, Ming Deng, Yonggang Ma, Jianghua Ming
    Journal of Biomedical Nanotechnology.2023; 19(10): 1783.     CrossRef
  • Characterisation and skin protection activities of polysaccharides from Schnabelia terniflora
    Ying Zhao, Yixian Liu, Huoxiang Zhou, Wei Guo, Weidong Wang, Huiping Chen
    Natural Product Research.2023; : 1.     CrossRef
  • Non-alcoholic fatty liver disease risk prediction model and health management strategies for older Chinese adults: a cross-sectional study
    Hong Pan, Baocheng Liu, Xin Luo, Xinxin Shen, Jijia Sun, An Zhang
    Lipids in Health and Disease.2023;[Epub]     CrossRef
  • Modulatory effects of polysaccharides from plants, marine algae and edible mushrooms on gut microbiota and related health benefits: A review
    Henan Zhang, Fuchun Jiang, Jinsong Zhang, Wenhan Wang, Lin Li, Jingkun Yan
    International Journal of Biological Macromolecules.2022; 204: 169.     CrossRef
  • Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification
    Guoyan Jiang, Chunhong Sun, Xiaodong Wang, Jie Mei, Chen Li, Honghong Zhan, Yixuan Liao, Yongjun Zhu, Jingxin Mao
    Bioengineered.2022; 13(3): 5216.     CrossRef
  • Gut Microbiome in Non-Alcoholic Fatty Liver Disease: From Mechanisms to Therapeutic Role
    Haripriya Gupta, Byeong-Hyun Min, Raja Ganesan, Yoseph Asmelash Gebru, Satya Priya Sharma, Eunju Park, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Ji-Ye Hyun, Jung-A. Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Do
    Biomedicines.2022; 10(3): 550.     CrossRef
  • Efficacy and Safety of Probiotics Combined With Traditional Chinese Medicine for Ulcerative Colitis: A Systematic Review and Meta-Analysis
    Yu Hu, Zhen Ye, Yingqi She, Linzhen Li, Mingquan Wu, Kaihua Qin, Yuzheng Li, Haiqing He, Zhipeng Hu, Maoyi Yang, Fating Lu, Qiaobo Ye
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Hepatoprotection of Probiotics Against Non-Alcoholic Fatty Liver Disease in vivo: A Systematic Review
    Faezah Sabirin, Siong Meng Lim, Chin Fen Neoh, Kalavathy Ramasamy
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Salvia miltiorrhiza Bge. (Danshen) in the Treating Non-alcoholic Fatty Liver Disease Based on the Regulator of Metabolic Targets
    Jie Liu, Yun Shi, Daiyin Peng, Lei Wang, Nianjun Yu, Guokai Wang, Weidong Chen
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases
    Yijing Ren, Siyue Li, Zixuan Song, Qiuping Luo, Yingying Zhang, Hao Wang
    Nutrients.2022; 14(11): 2303.     CrossRef
  • Astaxanthin Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Intestinal Flora and Targeting the AMPK/Nrf2 Signal Axis
    Yuhang Li, Juxiong Liu, Bojian Ye, Yueyao Cui, Ruiqi Geng, Shu Liu, Yufei Zhang, Wenjin Guo, Shoupeng Fu
    Journal of Agricultural and Food Chemistry.2022; 70(34): 10620.     CrossRef
  • Application of metabolomics in the diagnosis of non-alcoholic fatty liver disease and the treatment of traditional Chinese medicine
    Mingmei Shao, Yifei Lu, Hongjiao Xiang, Junmin Wang, Guang Ji, Tao Wu
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • The chemistry and efficacy benefits of polysaccharides from Atractylodes macrocephala Koidz
    Congying Liu, Shengguang Wang, Zedong Xiang, Tong Xu, Mengyuan He, Qing Xue, Huaying Song, Peng Gao, Zhufeng Cong
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • An Ethnopharmaceutical Study on the Hypolipidemic Formulae in Taiwan Issued by Traditional Chinese Medicine Pharmacies
    Min-Han Chi, Jung Chao, Chien-Yu Ko, Shyh-Shyun Huang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Three water soluble polysaccharides with anti-inflammatory activities from Selaginella uncinata (Desv.) Spring
    Haochen Hui, Meng Gao, Xuerong Zhao, Lianhong Yin, Lina Xu, Lili Li, Jinyong Peng
    International Journal of Biological Macromolecules.2022; 222: 1983.     CrossRef
  • Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis
    Xiang Chen, Menghan Liu, Jun Tang, Ning Wang, Yibin Feng, Haotian Ma
    International Journal of Molecular Sciences.2022; 23(19): 11710.     CrossRef
  • Modulation of gut microbiota by glycyrrhizic acid may contribute to its anti-NAFLD effect in rats fed a high-fat diet
    Sai Wang, Xin-Yu Li, Hong-Fang Ji, Liang Shen
    Life Sciences.2022; 310: 121110.     CrossRef
  • Structural Alteration of Gut Microbiota During the Amelioration of Chronic Psychological Stress-Aggravated Diabetes-Associated Cognitive Decline by a Traditional Chinese Herbal Formula, ZiBu PiYin Recipe
    Wen Zhou, Libin Zhan, Huiying Xu, Lijing Zhang
    Journal of Alzheimer's Disease.2022; 90(4): 1465.     CrossRef
  • Bacillus amyloliquefaciens SC06 in the diet improves egg quality of hens by altering intestinal microbiota and the effect is diminished by antimicrobial peptide
    Shujie Xu, Fei Wang, Peng Zou, Xiang Li, Qian Jin, Qi Wang, Baikui Wang, Yuanhao Zhou, Li Tang, Dongyou Yu, Weifen Li
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Effect of stigma maydis polysaccharide on the gut microbiota and transcriptome of VPA induced autism model rats
    Xiaolei Yang, Jiyuan Li, Yang Zhou, Ning Zhang, Jicheng Liu
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism
    Zi-Li Ai, Xian Zhang, Wei Ge, You-Bao Zhong, Hai-Yan Wang, Zheng-Yun Zuo, Duan-Yong Liu
    World Journal of Gastroenterology.2022; 28(43): 6131.     CrossRef
  • Dysregulated hepatic lipid metabolism and gut microbiota associated with early-stage NAFLD in ASPP2-deficiency mice
    Fang Xie, Hang-fei Xu, Jing Zhang, Xiao-ni Liu, Bu-xin Kou, Meng-yin Cai, Jing Wu, Jin-ling Dong, Qing-hua Meng, Yi Wang, Dexi Chen, Yang Zhang
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Structural elucidation and anti-nonalcoholic fatty liver disease activity of Polygonatum cyrtonema Hua polysaccharide
    Wei Liu, Taili Shao, Lei Tian, Zhengrui Ren, Lan Gao, Zhiyan Tang, Zheng Fang, Pingchuan Yuan, Chunyan Liu, Jikun Li, Guodong Wang, Jun Han
    Food & Function.2022; 13(24): 12883.     CrossRef
  • The protective effects of sulforaphane on high-fat diet-induced metabolic associated fatty liver disease in mice via mediating the FXR/LXRα pathway
    Shaotong Ma, Xinyi Pang, Shuhua Tian, Jing Sun, Qiaobin Hu, Xiangfei Li, Yingjian Lu
    Food & Function.2022; 13(24): 12966.     CrossRef
  • Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation
    Tingting Sang, Chengjie Guo, Dandan Guo, Jianjun Wu, Yujie Wang, Ying Wang, Jiajun Chen, Chaojie Chen, Kaikai Wu, Kun Na, Kang Li, Liu Fang, Cuiling Guo, Xingya Wang
    Carbohydrate Polymers.2021; 256: 117594.     CrossRef
  • Annual review of LSD1/KDM1A inhibitors in 2020
    Dong-Jun Fu, Jun Li, Bin Yu
    European Journal of Medicinal Chemistry.2021; 214: 113254.     CrossRef
  • Diet-Regulating Microbiota and Host Immune System in Liver Disease
    Jung A Eom, Goo Hyun Kwon, Na Yeon Kim, Eun Ju Park, Sung Min Won, Jin Ju Jeong, Ganesan Raja, Haripriya Gupta, Yoseph Asmelash Gebru, Satyapriya Sharma, Ye Rin Choi, Hyeong Seop Kim, Sang Jun Yoon, Ji Ye Hyun, Min Kyo Jeong, Hee Jin Park, Byeong Hyun Min
    International Journal of Molecular Sciences.2021; 22(12): 6326.     CrossRef
  • Lactobacillus johnsonii BS15 combined with abdominal massage on intestinal permeability in rats with nonalcoholic fatty liver and cell biofilm repair
    Wei Zhang, Huanan Li, Na Zhao, Xiongfei Luo, Siwen Liu, an Bao, Yingying Chen, Haiteng Wang, Junshi Wang, Jingui Wang
    Bioengineered.2021; 12(1): 6354.     CrossRef
  • Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review
    Hang-Yu Li, Dan-Dan Zhou, Ren-You Gan, Si-Yu Huang, Cai-Ning Zhao, Ao Shang, Xiao-Yu Xu, Hua-Bin Li
    Nutrients.2021; 13(9): 3211.     CrossRef
  • Correlation Analysis of Huayu Tongmai Decoction Intervention and Prognosis Indexes of Patients with Carotid Atherosclerosis
    Guangqing Cheng, Xiaoni Yan, Fengmeng Wang, Chao Chen, Muhammad Wasim Khan
    Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
  • Targeting the gut microbiota by Asian and Western dietary constituents: a new avenue for diabetes
    Abdul Rahman Conteh, Ruixue Huang
    Toxicology Research.2020; 9(4): 569.     CrossRef
  • MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice
    Shu Fang, Jie Feng, Hongbin Zhang, Ping Li, Yudan Zhang, Yanmei Zeng, Yingying Cai, Xiaochun Lin, Yaoming Xue, Meiping Guan
    Adipocyte.2020; 9(1): 179.     CrossRef
  • Chinese Medicinal Herbs Targeting the Gut–Liver Axis and Adipose Tissue–Liver Axis for Non-Alcoholic Fatty Liver Disease Treatments: The Ancient Wisdom and Modern Science
    Shuwei Zhang, Yui-Tung Wong, Ka-Yu Tang, Hiu-Yee Kwan, Tao Su
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Probiyotiklerin Kolon Mikrobiyotasına Etkileri: Güncel Çalışmalar
    Çağlar GÖKIRMAKLI, Zeynep SEYDİM
    Journal of Biotechnology and Strategic Health Research.2020; 4(3): 212.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer