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Obesity and Metabolic Syndrome
Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
Sungmi Park, Jae-Han Jeon, Byong-Keol Min, Chae-Myeong Ha, Themis Thoudam, Bo-Yoon Park, In-Kyu Lee
Diabetes Metab J. 2018;42(4):270-281.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0101
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AbstractAbstract PDFPubReader   

Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyruvate oxidation after glycolysis and fuels the Krebs cycle to meet energy demands. Fine-tuning of PDC activity has been mainly attributed to post-translational modifications of its subunits, including the extensively studied phosphorylation and de-phosphorylation of the E1α subunit of pyruvate dehydrogenase (PDH), modulated by kinases (pyruvate dehydrogenase kinase [PDK] 1-4) and phosphatases (pyruvate dehydrogenase phosphatase [PDP] 1-2), respectively. In addition to phosphorylation, other covalent modifications, including acetylation and succinylation, and changes in metabolite levels via metabolic pathways linked to utilization of glucose, fatty acids, and amino acids, have been identified. In this review, we will summarize the roles of PDC in diverse tissues and how regulation of its activity is affected in various metabolic disorders.

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    Ricardo Amorim, Carina C. Magalhães, Sofia Benfeito, Fernando Cagide, Ludgero C. Tavares, Katia Santos, Vilma A. Sardão, Sandipan Datta, Gino A. Cortopassi, Inês Baldeiras, John G. Jones, Fernanda Borges, Paulo J. Oliveira, José Teixeira
    Biochemical Pharmacology.2024; 219: 115953.     CrossRef
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    Alex H.Y. Chan, Terence C.S. Ho, Finian J. Leeper
    Bioorganic & Medicinal Chemistry Letters.2024; 98: 129571.     CrossRef
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    Kuo Chi, Jing Liu, Xinghua Li, He Wang, Yanliang Li, Qingnan Liu, Yabin Zhou, Yuan Ge
    Molecular Omics.2024; 20(3): 169.     CrossRef
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    Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke, Pablo Lazcano, Simone W. Denis, Mária Balážová, Nevton da Rosa Teixeira J, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H. Houtkooper, Miriam L. Greenberg
    Scientific Reports.2024;[Epub]     CrossRef
  • Effects of ambient UVB light on Pacific oyster Crassostrea gigas mantle tissue based on multivariate data
    Hongce Song, Chaoyi Xie, Meiyun Dong, Yuxuan Zhang, Haifeng Huang, Yijing Han, Yaqiong Liu, Lei Wei, Xiaotong Wang
    Ecotoxicology and Environmental Safety.2024; 274: 116236.     CrossRef
  • Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer
    Jun-Jie Zhu, Feng-Ying Huang, Hengyu Chen, Yun-long Zhang, Ming-Hui Chen, Ri-Hong Wu, Shu-Zhen Dai, Gui-Sheng He, Guang-Hong Tan, Wu-Ping Zheng, Sreeparna Banerjee
    PLOS ONE.2024; 19(3): e0299571.     CrossRef
  • Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1
    Guangzhao Zhu, Fangxia Guan, Shenglei Li, Qing Zhang, Xueying Zhang, Yue Qin, Zhangzhan Sun, Shaohua Peng, Jiexing Cheng, Yiyang Li, Ruili Ren, Tianli Fan, Hongtao Liu
    Molecular Carcinogenesis.2024; 63(5): 897.     CrossRef
  • In Vitro and In Silico Studies on Cytotoxic Properties of Oxythiamine and 2′-Methylthiamine
    Marta Malinowska, Magdalena Czerniecka, Izabella Jastrzebska, Artur Ratkiewicz, Adam Tylicki, Natalia Wawrusiewicz-Kurylonek
    International Journal of Molecular Sciences.2024; 25(8): 4359.     CrossRef
  • Protein lipoylation: mitochondria, cuproptosis, and beyond
    Cheng-Han Lin, Yeh Chin, Ming Zhou, Robert W. Sobol, Mien-Chie Hung, Ming Tan
    Trends in Biochemical Sciences.2024;[Epub]     CrossRef
  • Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation
    Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
    Cellular and Molecular Gastroenterology and Hepatology.2023; 15(2): 439.     CrossRef
  • Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy
    Gregory Pappas, Melissa L. Wilkinson, Andrew J. Gow
    Nitric Oxide.2023; 131: 8.     CrossRef
  • Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis
    Alex H. Y. Chan, Terence C. S. Ho, Daniel R. Parle, Finian J. Leeper
    Organic & Biomolecular Chemistry.2023; 21(8): 1755.     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
  • The Impact of Krebs Cycle Intermediates on the Endocrine System and Immune System: A Comparison
    Borros M. Arneth
    Endocrines.2023; 4(1): 179.     CrossRef
  • Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
    Giovan N. Cholico, Karina Orlowska, Russell R. Fling, Warren J. Sink, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Tim Zacharewski
    Scientific Reports.2023;[Epub]     CrossRef
  • The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
    Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee
    Diabetes & Metabolism Journal.2023; 47(2): 153.     CrossRef
  • Targeting PDK2 rescues stress-induced impaired brain energy metabolism
    Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang
    Molecular Psychiatry.2023; 28(10): 4138.     CrossRef
  • The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation
    Min-Ji Kim, Hoyul Lee, Dipanjan Chanda, Themis Thoudam, Hyeon-Ji Kang, Robert A. Harris, In-Kyu Lee
    Molecules and Cells.2023; 46(5): 259.     CrossRef
  • Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
    Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah
    Kidney International.2023; 104(4): 724.     CrossRef
  • PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation
    Sheng An, Yi Yao, Hongbin Hu, Junjie Wu, Jiaxin Li, Lulan Li, Jie Wu, Maomao Sun, Zhiya Deng, Yaoyuan Zhang, Shenhai Gong, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng
    Cell Death & Disease.2023;[Epub]     CrossRef
  • Iron promotes glycolysis to drive colon tumorigenesis
    Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M. Falcon, Mohammad Haneef, David R. Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer, Costas A. Lyssiotis, Yatrik M. Shah, Henry C. Lin, Hui-kuan Lin, Xiang Xue
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166846.     CrossRef
  • Driving force of deteriorated cellular environment in heart failure: Metabolic remodeling
    Lu Fan, Chenchen Meng, Xiaoming Wang, Yunjiao Wang, Yanyang Li, Shichao Lv, Junping Zhang
    Clinics.2023; 78: 100263.     CrossRef
  • Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease
    Hoyul Lee, Jae-Han Jeon, Eun Soo Kim
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism
    Lei Dou, Enting Lu, Dongli Tian, Fangmei Li, Lei Deng, Yi Zhang
    Journal of Translational Internal Medicine.2023; 11(2): 169.     CrossRef
  • Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington’s disease
    Sai Sanwid Pradhan, Sai Swaroop R., Sai Phalguna Kanikaram, Datta Darshan V.M., Ashish Pargaonkar, Rajesh Babu Dandamudi, Venketesh Sivaramakrishnan
    Journal of Biomolecular Structure and Dynamics.2023; : 1.     CrossRef
  • Unique and generic crossed metabolism in response to four sub-lethal environmental stresses in the oriental fruit fly, Bactrocera dorsalis Hendel
    Lili Ren, Hongxia Zhang, Jiao Zhou, Yajing Wu, Bo Liu, Shuping Wang, Xin Liu, Xin Hao, Lilin Zhao
    Ecotoxicology and Environmental Safety.2023; 264: 115434.     CrossRef
  • Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
    Raheleh Farahzadi, Behnaz Valipour, Ezzatollah Fathi, Samaneh Pirmoradi, Ommoleila Molavi, Soheila Montazersaheb, Zohreh Sanaat
    Stem Cell Research & Therapy.2023;[Epub]     CrossRef
  • Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways
    Donatas Stakišaitis, Linas Kapočius, Evelina Kilimaitė, Dovydas Gečys, Lina Šlekienė, Ingrida Balnytė, Jolita Palubinskienė, Vaiva Lesauskaitė
    Pharmaceutics.2023; 15(12): 2715.     CrossRef
  • Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
    Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance
    Shogo Imanaka, Hiroshi Shigetomi, Hiroshi Kobayashi
    Reproductive Sciences.2022; 29(3): 653.     CrossRef
  • Renal denervation ameliorates cardiac metabolic remodeling in diabetic cardiomyopathy rats by suppressing renal SGLT2 expression
    Jun-Yu Huo, Wan-Ying Jiang, Shi-Geng Zhang, Yi-Ting Lyu, Jie Geng, Meng Chen, Yuan-Yuan Chen, Zhi-Xin Jiang, Qi-Jun Shan
    Laboratory Investigation.2022; 102(4): 341.     CrossRef
  • Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration
    Yuying Zhang, Baoyi Zhu, Yi Cai, Sihua Zhu, Hongjun Zhao, Xiaoling Ying, Chonghe Jiang, Jianwen Zeng
    BMC Cancer.2022;[Epub]     CrossRef
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    Xiaoqian Tang, Ting Liu, Xiaoai Li, Xiuzhen Sheng, Jing Xing, Heng Chi, Wenbin Zhan
    Fish & Shellfish Immunology.2022; 122: 106.     CrossRef
  • The Critical Role Played by Mitochondrial MITF Serine 73 Phosphorylation in Immunologically Activated Mast Cells
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    Cells.2022; 11(3): 589.     CrossRef
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    Biomolecules.2022; 12(2): 272.     CrossRef
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    International Journal of Molecular Sciences.2022; 23(3): 1857.     CrossRef
  • Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses
    Chengcheng Yin, Zuodeng Sun, Chenglong Ji, Fei Li, Huifeng Wu
    Journal of Hazardous Materials.2022; 434: 128824.     CrossRef
  • Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
    Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
    Abu Jubayer Hossain, Rokibul Islam, Jae-Gyu Kim, Oyungerel Dogsom, Kim Cuong Cap, Jae-Bong Park
    Biomedicines.2022; 10(6): 1256.     CrossRef
  • Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
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    Toxicology and Applied Pharmacology.2022; 449: 116099.     CrossRef
  • Regulation of Metabolism by Mitochondrial MUL1 E3 Ubiquitin Ligase
    Lucia Cilenti, Rohit Mahar, Jacopo Di Gregorio, Camilla T. Ambivero, Matthew E. Merritt, Antonis S. Zervos
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • The Pyruvate Dehydrogenase Complex Mitigates LPS-Induced Endothelial Barrier Dysfunction by Metabolic Regulation
    Liangfeng Mao, Maomao Sun, Zhenfeng Chen, Zhenhua Zeng, Jie Wu, Zhongqing Chen, Weijin Zhang, Qiaobing Huang
    Shock.2022; 57(6): 308.     CrossRef
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    Molecules and Cells.2022; 45(7): 454.     CrossRef
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    Biomedicines.2022; 10(12): 3171.     CrossRef
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    Cell Death & Disease.2022;[Epub]     CrossRef
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    Molecular Metabolism.2021; 45: 101154.     CrossRef
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    Dragana Savic, Vicky Ball, Lorenz Holzner, David Hauton, Kerstin N. Timm, M. Kate Curtis, Lisa C. Heather, Damian J. Tyler
    NMR in Biomedicine.2021;[Epub]     CrossRef
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    Cells.2021; 10(4): 762.     CrossRef
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    Dana M. Zaher, Iman M. Talaat, Amal Hussein, Mahmood Y. Hachim, Hany A. Omar
    Life Sciences.2021; 284: 119885.     CrossRef
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    Journal of Biological Chemistry.2020; 295(22): 7743.     CrossRef
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    EMBO reports.2020;[Epub]     CrossRef
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    Journal of Translational Medicine.2020;[Epub]     CrossRef
  • Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
    Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease
    Ecem Kaya, David A. Smith, Claire Smith, Barry Boland, Michael Strupp, Frances M. Platt
    Journal of Clinical Medicine.2020; 9(4): 1050.     CrossRef
  • Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
    Shaoning Jiang, April M. Teague, Jeanie B. Tryggestad, Timothy J. Lyons, Steven D. Chernausek
    Molecular Medicine.2020;[Epub]     CrossRef
  • SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity
    Rakhee Yadav, Sandeep Aggarwal, Archna Singh
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(5): 1355.     CrossRef
  • Effect of flaxseed oil on muscle protein loss and carbohydrate oxidation impairment in a pig model after lipopolysaccharide challenge
    Ping Kang, Yang Wang, Xiangen Li, Zhicheng Wan, Xiuying Wang, Huiling Zhu, Chunwei Wang, Shengjun Zhao, Huifu Chen, Yulan Liu
    British Journal of Nutrition.2020; 123(8): 859.     CrossRef
  • Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex
    B. O. Forsberg, S. Aibara, R. J. Howard, N. Mortezaei, E. Lindahl
    Nature Communications.2020;[Epub]     CrossRef
  • The potential impacts of obesity on COVID-19
    Ahmed Abdalazim Dafallah Albashir
    Clinical Medicine.2020; 20(4): e109.     CrossRef
  • Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism
    Subhashis Pal, Konica Porwal, Sangam Rajak, Rohit A. Sinha, Naibedya Chattopadhyay
    Biomedicine & Pharmacotherapy.2020; 127: 110207.     CrossRef
  • Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients
    Amany Magdy Beshbishy, Helal F. Hetta, Diaa E. Hussein, Abdullah A. Saati, Christian C. Uba, Nallely Rivero-Perez, Adrian Zaragoza-Bastida, Muhammad Ajmal Shah, Tapan Behl, Gaber El-Saber Batiha
    Biology.2020; 9(9): 280.     CrossRef
  • Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
    Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
    Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall
    Journal of Leukocyte Biology.2020; 107(3): 467.     CrossRef
  • Short-term high-fat diet intake leads to exacerbation of concanavalin A-induced liver injury through the induction of procoagulation state
    Eri Nanizawa, Yuki Tamaki, Reika Sono, Rintaro Miyashita, Yumi Hayashi, Ayumu Kanbe, Hiroyasu Ito, Tetsuya Ishikawa
    Biochemistry and Biophysics Reports.2020; 22: 100736.     CrossRef
  • Role of the Mitochondrial Pyruvate Carrier in the Occurrence of Metabolic Inflexibility in Drosophila melanogaster Exposed to Dietary Sucrose
    Chloé J. Simard, Mohamed Touaibia, Eric Pierre Allain, Etienne Hebert-Chatelain, Nicolas Pichaud
    Metabolites.2020; 10(10): 411.     CrossRef
  • Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency
    Denisa Hathazi, Helen Griffin, Matthew J Jennings, Michele Giunta, Christopher Powell, Sarah F Pearce, Benjamin Munro, Wei Wei, Veronika Boczonadi, Joanna Poulton, Angela Pyle, Claudia Calabrese, Aurora Gomez‐Duran, Ulrike Schara, Robert D S Pitceathly, M
    The EMBO Journal.2020;[Epub]     CrossRef
  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
    Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
  • Recent advances in the pathogenesis of microvascular complications in diabetes
    Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
    Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
  • Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase activity
    Changyeol Lee, Wei Li, Sunghee Bang, Sun Joo Lee, Nam-young Kang, Soonok Kim, Tae In Kim, Younghoon Go, Sang Hee Shim
    Molecules.2019; 24(24): 4450.     CrossRef
  • Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure
    Freya L. Sheeran, Julie Angerosa, Norman Y. Liaw, Michael M. Cheung, Salvatore Pepe
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Progression of Multifaceted Immune Cells in Atherosclerotic Development
    Sungmi Park, In-Kyu Lee
    Journal of Lipid and Atherosclerosis.2019; 8(1): 15.     CrossRef
  • SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis
    Lei Xu, Yang Li, Lixing Zhou, Robert Gregory Dorfman, Li Liu, Rui Cai, Chenfei Jiang, Dehua Tang, Yuming Wang, Xiaoping Zou, Lei Wang, Mingming Zhang
    Cancer Medicine.2019; 8(5): 2380.     CrossRef
  • Differential Mechanism of ATP Production Occurs in Response to Succinylacetone in Colon Cancer Cells
    Lee, Woo, Yoo, Cho, Kim
    Molecules.2019; 24(19): 3575.     CrossRef
  • Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
    Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
    Cells.2019; 8(11): 1449.     CrossRef
  • NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism
    Rufeng Zhang, Tingting Hou, Heping Cheng, Xianhua Wang
    The FASEB Journal.2019; 33(12): 13310.     CrossRef
  • Mitochondrial Flexibility of Breast Cancers: A Growth Advantage and a Therapeutic Opportunity
    Angelica Avagliano, Maria Rosaria Ruocco, Federica Aliotta, Immacolata Belviso, Antonello Accurso, Stefania Masone, Stefania Montagnani, Alessandro Arcucci
    Cells.2019; 8(5): 401.     CrossRef
  • Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
    Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo
    European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
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