Diabetes & Metabolism Journal

Brief Report

Complications
Diabetic Ketoacidosis as an Effect of Sodium-Glucose Cotransporter 2 Inhibitor: Real World Insights: Han-Sang Baek, Chaiho Jeong, Yeoree Yang, Joonyub Lee, Jeongmin Lee, Seung-Hwan Lee, Jae Hyoung Cho, Tae-Seo Sohn, Hyun-Shik Son, Kun-Ho Yoon, Eun Young Lee; Diabetes Metab J. 2024;48(6):1169-1175. Published online June 10, 2024; DOI: https://doi.org/10.4093/dmj.2024.0036

22,508 View
531 Download
18 Web of Science
22 Crossref

One of the notable adverse effects of sodium-glucose cotransporter 2 (SGLT2) inhibitor is diabetic ketoacidosis (DKA) often characterized by euglycemia. In this retrospective review of patients with DKA from 2015 to 2023, 21 cases of SGLT2 inhibitorassociated DKA were identified. Twelve (57.1%) exhibited euglycemic DKA (euDKA) while nine (42.9%) had hyperglycemic DKA (hyDKA). More than 90% of these cases were patients with type 2 diabetes mellitus. Despite similar age, sex, body mass index, and diabetes duration, individuals with hyDKA showed poorer glycemic control and lower C-peptide levels compared with euDKA. Renal impairment and acidosis were worse in the hyDKA group, requiring hemodialysis in two patients. Approximately one-half of hyDKA patients had concurrent hyperosmolar hyperglycemic state. Common symptoms included nausea, vomiting, general weakness, and dyspnea. Seizure was the initial manifestation of DKA in two cases. Infection and volume depletion were major contributors, while carbohydrate restriction and inadequate insulin treatment also contributed to SGLT2 inhibitor-associated DKA. Despite their beneficial effects, clinicians should be vigilant for SGLT2 inhibitor risk associated with DKA.

Citations

Citations to this article as recorded by

Fallbericht einer Euglykämischen Diabetischen Ketoacidose unter SGLT-2-Inhibition bei einer geriatrischen Patientin: „Sick-Day-Off Drug“
Laura Wassermann, Michael Denkinger
Zeitschrift für Gerontologie und Geriatrie.2026; 59(1): 74. CrossRef
The evolution of C-peptide's role in diabetes care
Laura Briggs, Alexander Read, Sarah Darch, Emma L. Williams, Wann Jia Loh, Julia S. Kenkre
Current Opinion in Endocrinology, Diabetes & Obesity.2026; 33(1): 16. CrossRef
Diabetic ketoacidosis is not a simple consequence of hyperglycemia, it is biochemical event driven by PDK4-mediated inhibition of PDC
Ayah Al-Qasrawi
Medical Hypotheses.2026; 208: 111898. CrossRef
Diabetic ketoacidosis in patients with type 2 diabetes: Risk factors for mortality and adverse outcomes
Vishnu Chandrabalan, Timothy Howcroft, Mohammed Khalid Alkhalifah, Noorulanne Younis, Ebrahim Aldhafiri, Joseph M Pappachan
World Journal of Experimental Medicine.2026;[Epub] CrossRef
Diabetes mellitus im Alter
Andrej Zeyfang, Jürgen Wernecke, Anke Bahrmann
Die Diabetologie.2026; 22(5): 593. CrossRef
The Diabetes–Viral Respiratory Syndemic: Pathophysiological Insights and Precision Management: A Scoping Review
Ana Maria Mihai, Monica Marc, Florina Lucaciu, Alexandra Sima
Medicina.2026; 62(4): 770. CrossRef
Metabolic Impact of Sodium-Glucose Cotransporter 2 Inhibitor-Induced Ketogenesis in Type 2 Diabetes Mellitus
Hee Woo Park, Hun Jee Choe, Ho Jun Lim, Sung Hye Kong, Tae Jung Oh, Min Joo Kim, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Joon Ho Moon
Journal of Obesity & Metabolic Syndrome.2026; 35(2): 211. CrossRef
Case Report: Early-onset euglycemic diabetic ketoacidosis following henagliflozin initiation in a treatment-naive patient
Jing Cai, Tiantian Fu, Cuixia Tan
Frontiers in Endocrinology.2026;[Epub] CrossRef
Ethanol as a Modifier of Drug Toxicity in Humans: Pathways of Toxicity and Organ-Level Consequences
Bożena Bukowska, Karol Bukowski, Marlena Broncel
International Journal of Molecular Sciences.2026; 27(14): 6270. CrossRef
Efficacy and Safety of the Dual SGLT1 and SGLT2 Inhibitor JP-2266 in Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study
Eun Young Lee, Kyung Ah Han, Soo Heon Kwak, Jun Hwa Hong, You-Cheol Hwang, Gwanpyo Koh, Jing W. Hughes, Soomee Kim, Chang-Seok Lee, Bong-Soo Cha
Diabetes & Metabolism Journal.2026;[Epub] CrossRef
Dapagliflozin/Empagliflozin/Ertugliflozin

Reactions Weekly.2025; 2042(1): 142. CrossRef
Diabetes Mellitus at an Elderly Age
Andrej Zeyfang, Jürgen Wernecke, Anke Bahrmann
Experimental and Clinical Endocrinology & Diabetes.2025; 133(04): 168. CrossRef
SGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application
Jae Hyun Bae
Diabetes & Metabolism Journal.2025; 49(3): 386. CrossRef
Diabetes mellitus im Alter
Andrej Zeyfang, Jürgen Wernecke, Anke Bahrmann
Die Diabetologie.2025; 21(4): 503. CrossRef
Cardiorenal outcomes and safety of SGLT2 inhibitors in patients with diabetes secondary to disorders of the exocrine pancreas: a nationwide population-based study
Kyoung Hwa Ha, Minae Park, Yujin Lee, Dae Jung Kim, Seung Jin Han
Diabetes & Metabolism.2025; 51(5): 101668. CrossRef
SGLT2 Inhibitors: From Structure–Effect Relationship to Pharmacological Response
Teodora Mateoc, Andrei-Luca Dumitrascu, Corina Flangea, Daniela Puscasiu, Tania Vlad, Roxana Popescu, Cristina Marina, Daliborca-Cristina Vlad
International Journal of Molecular Sciences.2025; 26(14): 6937. CrossRef
Euglycaemic diabetic ketoacidosis and its risk factors in patients undergoing coronary artery bypass grafting surgery: a single-centre nested case-control study in China
Rui Hu, Congchao Lu, Yifan Liu, Mengli Yang, Hongya Xing, Kerui Dai, Jiyin Li, Hui Zheng, Xi Chen, Nai-Jun Tang
BMJ Open.2025; 15(8): e098758. CrossRef
Acute heart failure in non-cardiac surgery
Danielle M Gualandro, Josep Masip, Sigrun Halvorsen, Susanna Price, Xavier Rosselló, Ovidiu Chioncel, W Frank Peacock, Òscar Miró, Mucio Tavares Oliveira Junior, Alexandre Mebazaa, Elke Platz, Offer Amir, Hannah Schaubroeck, Johannes Grand, Alessandro Sio
European Heart Journal.2025; 46(40): 4042. CrossRef
Severe euglycemic ketoacidosis following combined therapy with GLP-1 receptor agonist and SGLT-2 inhibitor, refractory to standard treatment: a case report
Agnieszka Gandecka-Pempera, Dariusz Naskręt, Anna Adamska, Dorota Zozulińska-Ziółkiewicz
Frontiers in Endocrinology.2025;[Epub] CrossRef
Sodium-Glucose Cotransporter 2 Inhibitors-Induced Euglycemic Ketoacidosis Mimicking Myocardial Infarction in a Non-Diabetic Heart Failure Patient
KilYoon Pack, Kyung Eun Ha, Taeil Yang, Wook-Jin Chung
International Journal of Heart Failure.2025; 7(4): 257. CrossRef
Diabetes mellitus im Alter
Andrej Zeyfang, Jürgen Wernecke, Anke Bahrmann
Diabetologie und Stoffwechsel.2025; 20(S 02): S234. CrossRef
Diabetes mellitus im Alter
Andrej Zeyfang, Jürgen Wernecke, Anke Bahrmann
Diabetologie und Stoffwechsel.2024; 19(S 02): S226. CrossRef

Review

Basic Research
Mitochondrial TFAM as a Signaling Regulator between Cellular Organelles: A Perspective on Metabolic Diseases: Jin-Ho Koh, Yong-Woon Kim, Dae-Yun Seo, Tae-Seo Sohn; Diabetes Metab J. 2021;45(6):853-865. Published online November 22, 2021; DOI: https://doi.org/10.4093/dmj.2021.0138

18,827 View
433 Download
45 Web of Science
51 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Tissues actively involved in energy metabolism are more likely to face metabolic challenges from bioenergetic substrates and are susceptible to mitochondrial dysfunction, leading to metabolic diseases. The mitochondria receive signals regarding the metabolic states in cells and transmit them to the nucleus or endoplasmic reticulum (ER) using calcium (Ca²⁺) for appropriate responses. Overflux of Ca²⁺ in the mitochondria or dysregulation of the signaling to the nucleus and ER could increase the incidence of metabolic diseases including insulin resistance and type 2 diabetes mellitus. Mitochondrial transcription factor A (Tfam) may regulate Ca²⁺ flux via changing the mitochondrial membrane potential and signals to other organelles such as the nucleus and ER. Since Tfam is involved in metabolic function in the mitochondria, here, we discuss the contribution of Tfam in coordinating mitochondria-ER activities for Ca²⁺ flux and describe the mechanisms by which Tfam affects mitochondrial Ca²⁺ flux in response to metabolic challenges.

Citations

Citations to this article as recorded by

β‐Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver
Ke Li, Lian Wang, Danlin Zhu, Wenhong Wang, Yifan Guo, Haoyang Gao, Muge Zhou, Weihua Xiao
Aging Cell.2026;[Epub] CrossRef
Alterations in Mitochondrial DNA in Corneal Fibroblast and Myofibroblast Post Injury
Nishant R. Sinha, Alexandria C. Hofmann, Laila A. Suleiman, Maxwell T. Jeffrey, Rajnish Kumar, Rajiv R. Mohan
Investigative Ophthalmology & Visual Science.2026; 67(1): 36. CrossRef
AiTFAM modulates growth and thermotolerance of scallop Argopecten irradians irradians via regulating mitochondrial dynamics
Xiaoxing Zhao, Jiaxi Chang, Junhao Zhang, Longfei Chu, Zhicheng Ruan, Chao Yu, Ancheng Liu, Jian Liu, Lisui Bao, Xiaoting Huang, Qiang Xing, Zhenmin Bao
Aquaculture.2026; 616: 743686. CrossRef
Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme
Mediators of Inflammation.2026;[Epub] CrossRef
Forsythiaside A inhibits the progression of intrahepatic cholangiocarcinoma partially via suppressing oxidative stress-induced hepatic stellate cell activation and macrophage polarization
Shiyu Zhang, Fan Du, Ye Liao, Chuyu Zhang, Meixia Zhang
BMC Biotechnology.2026;[Epub] CrossRef
Bone morphogenetic protein receptor 2 signaling mediates mitochondrial Ca2+ transport through its regulation of TAK1 splice variant
Ashley Toussaint, Manohar Singh, Hellen Chiou, Guoqiang Wang, Dongxuan Jia, Monica Driscoll, Vrushank Bhatt, Jean De La Croix Ndong, Sahil Shuaib, Harrison Zoltowski, John Gilleran, Youyi Peng, Anastasiia Tsymbal, Jacques Roberge, Jessie Yanxiang Guo, Dan
Cell Communication and Signaling.2026;[Epub] CrossRef
Three-dimensional (3D) culture-primed placental mesenchymal stem cells decrease cellular heterogeneity, significantly enhancing osteogenesis via improving mitochondrial function
Li-Tzu Wang, B. Linju Yen, Hsiu-Huan Wang, Yun-Fei Lin, Chien-Yu Liao, Pei-Ju Hsu, Men-Luh Yen
Materials Today Bio.2026; 37: 103012. CrossRef
Morinda officinalis polysaccharides activate the SIRT1/PGC-1α pathway to reduce oxidative damage in Leydig TM3 cells
Minhao Fu, Shengyun Wu, Xianlai Yin, Peng Yang, Binghao Gong, Zhenting Wang
Scientific Reports.2026;[Epub] CrossRef
NEK6 Knockout Causes Defects in Mitochondrial Morphology and Respiration
Fernando Riback da Silva, Pedro Rafael Firmino Dias, Isadora Carolina Betim Pavan, Andressa Peres de Oliveira, Fernanda Luisa Basei, Leticia Ester dos Santos, Lizandra Maia de Sousa, Sílvio Roberto Consonni, André Gustavo de Oliveira, Leonardo Reis Silvei
Cells.2026; 15(10): 924. CrossRef
Early-life mitochondrial impact of prenatal DL-PCB exposure: A signal from cord blood mtDNA
Chen Yang, Xiang Li, Xiaohui Zhang, Hua Chang, Hui Li, Lulu Liu, Bingnan Liu, Zaili Zhang
Ecotoxicology and Environmental Safety.2026; 319: 120207. CrossRef
Epigenetic and metabolic reprogramming in autoimmune rheumatology: toward immune tolerance reprogramming
Ola A Al-Ewaidat, Moawiah M Naffaa
Exploration of Immunology.2026;[Epub] CrossRef
Remodeling of the mitochondrial quality control network: natural products intervening in diabetic retinopathy
Tingru Chen, Ruolan Wu, Xinyi Liu, Yutong Jiang, Qun Huang, Ninghui Wan
Frontiers in Pharmacology.2026;[Epub] CrossRef
The Use of Lycium barbarum Polysaccharides to Control Liver Disease: A Review
Li-Jun Wang, Jian-Guang Sun, Shu-Cheng Chen, Ping Zhang, Yu-Li Sun, Yang Zheng, Jian-Chao Feng
World Journal of Traditional Chinese Medicine.2026;[Epub] CrossRef
Tuna blood hydrolysate mitigates exercise-induced muscle fatigue via energy metabolism and mitochondrial biogenesis
Daraphan Rodthayoy, Pennapa Chonpathompikunlert, Panlekha Rungruang, Wanwimol Klaypradit, Veerawat Sansri, Wachirapong Saleeon, Morakot Sroyraya
Food Bioscience.2026; 83: 109482. CrossRef
Polyphenol-Rich Euterpe oleracea Mart. Seed Extract Improves High-Fat-Diet-Induced MASLD Through Modulation of Hepatic Mitochondrial Respiration, Biogenesis, and Redox Homeostasis
Dafne L. Beserra-Silva, Julia F. Gouveia, Beatriz C. de Oliveira, Mariana A. Cavalheira, Natália P. A. Nogueira, Marcia Cristina Paes, Simone V. da Silva, Ana Lucia R. Nascimento, Jorge José de Carvalho, Dayane T. Ognibene, Cristiane A. da Costa, Graziele
Molecules.2026; 31(16): 2925. CrossRef
Reframing neuropsychiatric disorders: Nuclear calcium signaling as a core signaling axis of mitochondrial proteostasis and synaptic energy homeostasis
Maneesh Mohan, Ashi Mannan, Debasmita Mondal, Charu Chabara, Sanya Aneja, Vetriselvan Subramaniyan, Thakur Gurjeet Singh
Molecular and Cellular Neuroscience.2026; : 104114. CrossRef
Mitochondrial Function in Neurons and Glia in Health and Its Alteration in Parkinson's Disease: A Review
Monika Kaushik, Mrugendra Potdar, Prathap Madeswaraguptha, Murugesan Vanangamudi, Md Abubakar, Manoj Kumar Mishra, Sachchida Nand Rai
Current Neuropharmacology.2026; 24(9): 1276. CrossRef
When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness
May-Kristin Torp, Kåre-Olav Stensløkken, Jarle Vaage
Journal of Intensive Care Medicine.2025; 40(7): 695. CrossRef
Mitochondrial DAMPs: Key mediators in neuroinflammation and neurodegenerative disease pathogenesis
Haihan Yu, Kaidi Ren, Yage Jin, Li Zhang, Hui Liu, Zhen Huang, Ziheng Zhang, Xing Chen, Yang Yang, Ziqing Wei
Neuropharmacology.2025; 264: 110217. CrossRef
Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment
Qi Li, Jin Shang, Reiko Inagi
Kidney International Reports.2025; 10(4): 994. CrossRef
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis
Jianqiang Wu, Lixia Chen, Peijun Wen
Scientific Reports.2025;[Epub] CrossRef
The role of mitochondrial biogenesis, mitochondrial dynamics and mitophagy in gastrointestinal tumors
Yihong Liu, Hao Wang, Shen Zhang, Na Peng, Shuangshuang Hai, Haibo Zhao, Jingwei Liu, Weixin Liu
Cancer Cell International.2025;[Epub] CrossRef
Impact of POU3F4 mutation on cochlear development and auditory function
Jiong Dang, Panpan Bian, Chao Chen, Chi Chen, Wenqi Shan, Luhang Cai, Yong Li, Huan Tan, Baicheng Xu, Minxin Guan, Yufen Guo
Cell Communication and Signaling.2025;[Epub] CrossRef
Exploiting the cardioprotective potential of metformin against cardiotoxic agents
Ahmad Safari Maleki, A. Wallace Hayes, Gholamreza Karimi
Naunyn-Schmiedeberg's Archives of Pharmacology.2025; 398(12): 16293. CrossRef
Gut microbiota modified by Mulberry leaf water extract improves T2DM through browning of WAT/BAT activation mediated by SCFAs-AMPK/SIRT1/PGC-1α signaling pathway
Yuhang Du, Changhao He, Yongcheng An, Yige Zhao, Huilin Zhang, Ziyi Shan, Yang Yang, Menglu Wang, Jiamei Xie, Yan Huang, Wanxin Fu, Yueying Yuan, Baosheng Zhao
Journal of Ethnopharmacology.2025; 353: 120408. CrossRef
Dynorphin A Impairs Mitochondrial Biogenesis in Osteosarcoma Cells by Increasing SP‐1
Yaxiong Dai, Jian Zhang, Yingzhen Peng, Lingyan Hu
Journal of Biochemical and Molecular Toxicology.2025;[Epub] CrossRef
Effects of nutrients and diet on mitochondrial dysfunction: An opportunity for therapeutic approaches in human disease
Lisa H. Do, Renata T. Da Costa, Maria E. Solesio
Biomedicine & Pharmacotherapy.2025; 191: 118493. CrossRef
The impact of maternal diet-induced obesity on offspring primordial oocyte mitochondria at birth and at weaning
Waleed F A Marei, Inne Xhonneux, Axelle Buydens, Isabel Pintelon, Ben Meulders, Silke Andries, Jo L M R Leroy
Molecular Human Reproduction.2025;[Epub] CrossRef
Semiquantitative immunohistochemical (IHC) pixelwise H-score of mitochondrial transcription factor A (TFAM) in gastric adenocarcinoma (GAC): clinicopathological significance and association with p53 and HER2
Liang-Hung Ou, Hui-Ting Lee, Chia-I Lin, Yung-Hui Li, Wan-Chun Li, Chen-Sung Lin, Chiang-Ting Chien
World Journal of Surgical Oncology.2025;[Epub] CrossRef
Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong
Bingjia Zhao, Qian Zhang, Yiqian He, Weifang Cao, Wei Song, Xiaochun Liang
Journal of Pharmaceutical Analysis.2024; 14(2): 225. CrossRef
Mitochondrial damage‐associated molecular patterns: A new insight into metabolic inflammation in type 2 diabetes mellitus
Yan Wang, Jingwu Wang, Si‐Yu Tao, Zhengting Liang, Rong xie, Nan‐nan Liu, Ruxue Deng, Yuelin Zhang, Deqiang Deng, Guangjian Jiang
Diabetes/Metabolism Research and Reviews.2024;[Epub] CrossRef
Altered Energy Metabolism, Mitochondrial Dysfunction, and Redox Imbalance Influencing Reproductive Performance in Granulosa Cells and Oocyte During Aging
Hiroshi Kobayashi, Chiharu Yoshimoto, Sho Matsubara, Hiroshi Shigetomi, Shogo Imanaka
Reproductive Sciences.2024; 31(4): 906. CrossRef
The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases
Ying Song, Wenjun Wang, Beibei Wang, Qiwen Shi
Molecular Neurobiology.2024; 61(7): 4381. CrossRef
Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen
Journal of Biomedical Science.2024;[Epub] CrossRef
The role of mitochondrial damage-associated molecular patterns in acute pancreatitis
Yan Zhou, Xiaoyi Huang, Yinglu Jin, Minhao Qiu, Peter C. Ambe, Zarrin Basharat, Wandong Hong
Biomedicine & Pharmacotherapy.2024; 175: 116690. CrossRef
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA
Hao Liu, Cien Zhen, Jianming Xie, Zhenhuan Luo, Lin Zeng, Guojun Zhao, Shaohua Lu, Haixia Zhuang, Hualin Fan, Xia Li, Zhaojie Liu, Shiyin Lin, Huilin Jiang, Yuqian Chen, Jiahao Cheng, Zhiyu Cao, Keyu Dai, Jinhua Shi, Zhaohua Wang, Yongquan Hu, Tian Meng,
Nature Cell Biology.2024; 26(6): 878. CrossRef
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome
Yaqiong Li, Lei Tian, Siyuan Li, Xiaoniao Chen, Fengyang Lei, Jiayu Bao, Qianru Wu, Ya Wen, Ying Jie
Free Radical Biology and Medicine.2024; 222: 106. CrossRef
Prolonged Hypoxic Exposure Impairs Endothelial Functions: Possible Mechanism of HIF-1α Signaling
Junyoung Hong, Junchul Shin
Exercise Science.2024; 33(2): 168. CrossRef
Protein Arginine Methyltransferases: Emerging Targets in Cardiovascular and Metabolic Disease
Yan Zhang, Shibo Wei, Eun-Ju Jin, Yunju Jo, Chang-Myung Oh, Gyu-Un Bae, Jong-Sun Kang, Dongryeol Ryu
Diabetes & Metabolism Journal.2024; 48(4): 487. CrossRef
Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia
Huynh Cao, Jeffrey Xiao, David J. Baylink, Vinh Nguyen, Nathan Shim, Jae Lee, Dave J. R. Mallari, Samiksha Wasnik, Saied Mirshahidi, Chien-Shing Chen, Hisham Abdel-Azim, Mark E. Reeves, Yi Xu
Biomedicines.2024; 12(10): 2250. CrossRef
TFAM and Mitochondrial Protection in Diabetic Kidney Disease
Siming Yu, Xinxin Lu, Chunsheng Li, Zehui Han, Yue Li, Xianlong Zhang, Dandan Guo
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 4355. CrossRef
Effect of High-Dose Vitamin C on Tendon Cell Degeneration—An In Vitro Study
Shusuke Ueda, Toru Ichiseki, Miyako Shimasaki, Daisuke Soma, Masaru Sakurai, Ayumi Kaneuji, Norio Kawahara
International Journal of Molecular Sciences.2024; 25(24): 13358. CrossRef
Effects of the anti-inflammatory drug celecoxib on cell death signaling in human colon cancer
Ryuto Maruyama, Yuki Kiyohara, Yasuhiro Kudo, Tomoyasu Sugiyama
Naunyn-Schmiedeberg's Archives of Pharmacology.2023; 396(6): 1171. CrossRef
gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis
Daria Shunkina, Anastasia Dakhnevich, Egor Shunkin, Olga Khaziakhmatova, Valeria Shupletsova, Maria Vulf, Alexandra Komar, Elena Kirienkova, Larisa Litvinova
Biomedicines.2023; 11(2): 396. CrossRef
Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway
Runmei Zou, Shuo Wang, Hong Cai, Yuwen Wang, Cheng Wang, Vivek Pandey
Cardiovascular Therapeutics.2023; 2023: 1. CrossRef
Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells
Damien Meng-Kiat Leow, Irwin Kee-Mun Cheah, Zachary Wei-Jie Fong, Barry Halliwell, Wei-Yi Ong
International Journal of Molecular Sciences.2023; 24(6): 5498. CrossRef
Effect of PPARγ on oxidative stress in diabetes-related dry eye
Jing Wang, Shuangping Chen, Xiuxiu Zhao, Qian Guo, Ruibo Yang, Chen Zhang, Yue Huang, Lechong Ma, Shaozhen Zhao
Experimental Eye Research.2023; 231: 109498. CrossRef
Chiisanoside Mediates the Parkin/ZNF746/PGC-1α Axis by Downregulating MiR-181a to Improve Mitochondrial Biogenesis in 6-OHDA-Caused Neurotoxicity Models In Vitro and In Vivo: Suggestions for Prevention of Parkinson’s Disease
Yu-Ling Hsu, Hui-Jye Chen, Jia-Xin Gao, Ming-Yang Yang, Ru-Huei Fu
Antioxidants.2023; 12(9): 1782. CrossRef
TBBPA causes apoptosis in grass carp hepatocytes involving destroyed ER-mitochondrial function
Dongxu Han, Naixi Yang, Huanyi Liu, Yujie Yao, Shiwen Xu
Chemosphere.2023; 341: 139974. CrossRef
Impact of Roux-en-Y Gastric Bypass on Mitochondrial Biogenesis and Dynamics in Leukocytes of Obese Women
Zaida Abad-Jiménez, Teresa Vezza, Sandra López-Domènech, Meylin Fernández-Reyes, Francisco Canet, Carlos Morillas, Segundo Ángel Gómez-Abril, Celia Bañuls, Víctor M. Víctor, Milagros Rocha
Antioxidants.2022; 11(7): 1302. CrossRef
The Effects of Galgunhwanggumhwangryun-tang on Glucose and Energy Metabolism in C2C12 Myotubes
Jihong Oh, Song-Yi Han, Soo Kyoung Lim, Hojun Kim
Journal of Korean Medicine for Obesity Research.2022; 22(2): 93. CrossRef

Original Article

Angiotensin II Inhibits Insulin Binding to Endothelial Cells: Su-Jin Oh, Won-Chul Ha, Jee-In Lee, Tae-Seo Sohn, Ji-Hyun Kim, Jung-Min Lee, Sang-Ah Chang, Oak-Kee Hong, Hyun-Shik Son; Diabetes Metab J. 2011;35(3):243-247. Published online June 30, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.3.243

8,139 View
29 Download
6 Crossref

Abstract PDF PubReader ePub

Background

Insulin-mediated glucose uptake in insulin target tissues is correlated with interstitial insulin concentration, rather than plasma insulin concentration. Therefore, insulin delivery to the interstitium of target tissues is very important, and the endothelium may also play an important role in the development of insulin resistance.

Methods

After treating bovine aortic endothelial cells with angiotensin II (ATII), we observed the changes in insulin binding capacity and the amounts of insulin receptor (IR) on the cell membranes and in the cytosol.

Results

After treatment of 10^-7M ATII, insulin binding was decreased progressively, up to 60% at 60 minutes (P<0.05). ATII receptor blocker (eprosartan) dose dependently improved the insulin binding capacity which was reduced by ATII (P<0.05). At 200 µM, eprosartan fully restored insulin binding capacity, althogh it resulted in only a 20% to 30% restoration at the therapeutic concentration. ATII did not affect the total amount of IR, but it did reduce the amount of IR on the plasma membrane and increased that in the cytosol.

Conclusion

ATII decreased the insulin binding capacity of the tested cells. ATII did not affect the total amount of IR but did decrease the amount of IR on the plasma membrane. Our data indicate that ATII decreases insulin binding by translocating IR from the plasma membrane to the cytosol. The binding of insulin to IR is important for insulin-induced vasodilation and transendothelial insulin transport. Therefore, ATII may cause insulin resistance through this endothelium-based mechanism.

Citations

Citations to this article as recorded by

Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle
Dino Premilovac, Emily Attrill, Stephen Rattigan, Stephen M Richards, Jeonga Kim, Michelle A Keske
Cardiovascular Research.2019; 115(3): 590. CrossRef
Angiotensin II type 2 receptor inhibits expression and function of insulin receptor in rat renal proximal tubule cells
Yang Yang, Caiyu Chen, Chunjiang Fu, Zaicheng Xu, Cong Lan, Yongchun Zeng, Zhi Chen, Pedro A. Jose, Ye Zhang, Chunyu Zeng
Journal of the American Society of Hypertension.2018; 12(2): 135. CrossRef
Endothelial function, its relation to arterial hypertension and the possibility of its modulation
Vladislav Biel, Jan Novák, Luděk Pluháček, Jiří Špác
Vnitřní lékařství.2018; 64(7-8): 762. CrossRef
Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease
Juan M. Saavedra
Cellular and Molecular Neurobiology.2016; 36(2): 259. CrossRef
Ameliorative effect of eprosartan on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats
Mohamed A. Morsy, Gehan H. Heeba, Magda E. Mahmoud
European Journal of Pharmacology.2015; 750: 90. CrossRef
Metabolic actions of angiotensin II and insulin: A microvascular endothelial balancing act
Ranganath Muniyappa, Sahzene Yavuz
Molecular and Cellular Endocrinology.2013; 378(1-2): 59. CrossRef

First
Prev
Page of 1
Next
Last

Search