Diabetes & Metabolism Journal

Original Article

Clinical Diabetes & Therapeutics
Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus: Eon Ju Jeon, Seong Yeon Hong, Ji Hyun Lee; Diabetes Metab J. 2017;41(6):457-465. Published online November 15, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.6.457

5,151 View
46 Download
15 Web of Science
16 Crossref

Background

The aim of this study was to evaluate adipokines concentration and insulin resistance according to maternal age or obesity at pregnancy and weight change at diagnosed gestational diabetes mellitus (GDM) in pregnant women with GDM.

Methods

This study included 57 pregnant women who were diagnosed with GDM at 24 to 28 weeks of gestation. The subjects were classified into two or three groups according to pre-pregnancy body mass index (BMI, <25 kg/m² vs. ≥25 kg/m²), maternal age at pregnancy (<35 years old vs. ≥35 years old), and weight change during pregnancy at screening for GDM (weight change below, within, and in excess of the recommended range). They were respectively compared in each group.

Results

Leptin, homeostasis model assessment of insulin resistance (HOMA-IR), and HOMA2-%B were increased in the group with pre-pregnancy BMI ≥25 kg/m². Leptin and HOMA-IR were positively correlated with BMI both before pregnancy and at screening for GDM. There were no significant correlations between HOMA-IR and adipokines. HOMA-IR showed positive correlation with HOMA2-%B and negative correlation with HOMA2-%S.

Conclusion

Leptin and HOMA-IR at diagnosed GDM were increased in the GDM patients with obesity before pregnancy. They were positively correlated with BMI both before pregnancy and at screening for GDM. The effect of maternal age at pregnancy and weight change during pregnancy at GDM screening on adipokines and insulin resistance might be less pronounced than the effect of maternal obesity.

Citations

Citations to this article as recorded by

Association between triglyceride glucose-body mass index and gestational diabetes mellitus: a prospective cohort study
Xiaomin Liang, Kai Lai, Xiaohong Li, Di Ren, Shuiqing Gui, Ying Li, Zemao Xing
BMC Pregnancy and Childbirth.2025;[Epub] CrossRef
L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus
Colm J. McElwain, Andrea Musumeci, Samprikta Manna, Fergus P. McCarthy, Cathal M. McCarthy
Journal of Reproductive Immunology.2024; 161: 104171. CrossRef
Serum progesterone, glycosylated hemoglobin and insulin levels with the risk of premature rupture of membranes in gestational diabetes mellitus
LiRong Zhou, XueSong Xiong, LianHua Chen
Clinics.2024; 79: 100461. CrossRef
Association of the comorbidity of gestational diabetes mellitus and hypertension disorders of pregnancy with birth outcomes
Xingxi Lin, Luhan Zhou, Shuting Si, Haoyue Cheng, Xialidan Alifu, Yiwen Qiu, Yan Zhuang, Ye Huang, Libi Zhang, Diliyaer Ainiwan, Hui Liu, Yunxian Yu
Frontiers in Endocrinology.2024;[Epub] CrossRef
The therapeutic effects of attending a one-day outpatient service on patients with gestational diabetes and different pre-pregnancy body mass indices
Yan-Min Cao, Min Ma, Wei Wang, Na-Na Cai
Frontiers in Public Health.2023;[Epub] CrossRef
Insulin Resistance in Gestational Diabetes Mellitus and Its Association With Anthropometric Fetal Indices
Tuan Dinh Le, Tien Minh Bui, Trinh Hien Vu, Nga Phi Thi Nguyen, Hoa Thanh Thi Tran, Son Tien Nguyen, Lan Ho Thi Nguyen, Manh Van Ngo, Hoang Huy Duong, Binh Thanh Vu, Hoa Trung Dinh, Binh Nhu Do, Duc-Cuong Le, Hien Thi Nguyen, Kien Trung Nguyen
Clinical Medicine Insights: Endocrinology and Diabetes.2022;[Epub] CrossRef
New Insights into Adipokines in Gestational Diabetes Mellitus
Jorge Valencia-Ortega, Rebeca González-Reynoso, Edgar G. Ramos-Martínez, Aldo Ferreira-Hermosillo, María I. Peña-Cano, Enrique Morales-Ávila, Renata Saucedo
International Journal of Molecular Sciences.2022; 23(11): 6279. CrossRef
The combination from ethanol extract of moringa leaves (Moringa oleifera L.) and ethanol extract of papaya leaves (Carica papaya L.) slows the tumor growth in sprague dawley rats induced 7,12-dimethylbenz(a)anthracene
Mutmainah Arif, Ika Yustisia, Padlianah
Medicina Clínica Práctica.2020; 3: 100100. CrossRef
Insulin resistance (IR) in pregnant women at the Mother and Child Hospital Khadijah, Makassar, Indonesia
Hasbobi Tabrang, Elizabet C. Jusuf, Himawan Sanusi
Enfermería Clínica.2020; 30: 84. CrossRef
Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
Kyung-Soo Kim, Seok Won Park, Yong-Wook Cho, Soo-Kyung Kim
Endocrinology and Metabolism.2020; 35(1): 97. CrossRef
Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation
Sophie-Christine de Aguiar Greca, Ioannis Kyrou, Ryan Pink, Harpal Randeva, Dimitris Grammatopoulos, Elisabete Silva, Emmanouil Karteris
Journal of Clinical Medicine.2020; 9(2): 405. CrossRef
Joint Associations of Maternal Gestational Diabetes and Hypertensive Disorders of Pregnancy With Overweight in Offspring
Yuying Gu, Jun Lu, Weiqin Li, Huikun Liu, Leishen Wang, Junhong Leng, Wei Li, Shuang Zhang, Shuting Wang, Jaakko Tuomilehto, Zhijie Yu, Xilin Yang, Andrea A. Baccarelli, Lifang Hou, Gang Hu
Frontiers in Endocrinology.2019;[Epub] CrossRef
Reduced Serum Adiponectin Level and Risk of Poststroke Depression in Patients with Ischemic Stroke
Junhua Yang, Guanghui Du, Jinyu Wang, Jia Chen, Chenghui Yang, Jia Li, Yun Zhang
Journal of Stroke and Cerebrovascular Diseases.2019; 28(2): 305. CrossRef
Letter: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65)
Ohk-Hyun Ryu
Diabetes & Metabolism Journal.2018; 42(1): 87. CrossRef
The importance of treating mild hyperglycemia in pregnant women with diabetes
Kyung-Soo Kim
The Korean Journal of Internal Medicine.2018; 33(6): 1079. CrossRef
Response: Adipokines and Insulin Resistance According to Characteristics of Pregnant Women with Gestational Diabetes Mellitus (Diabetes Metab J 2017;41:457-65)
Eon Ju Jeon, Ji Hyun Lee
Diabetes & Metabolism Journal.2018; 42(1): 90. CrossRef

Case Report

A Case of Diabetic Ketoacidosis in Gestational Diabetes Mellitus.: Myung Hwan Kim, Eui Dal Jung, Seung Pyo Hong, Gyu Hwan Bae, Sun Young Ahn, Eon Ju Jeon, Seong Yeon Hong, Ji Hyun Lee, Ho Sang Son; Korean Diabetes J. 2007;31(4):368-371. Published online July 1, 2007; DOI: https://doi.org/10.4093/jkda.2007.31.4.368

2,561 View
42 Download

Abstract PDF: Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variant severity with onset or first recognition during present pregnancy. Recently the prevalence of GDM in Korean has reported as 1.7~4.0%. Diabetic ketoacidosis is a serious metabolic complication of diabetes with high mortality if undetected. Its occurrence is very rare in gestational diabetes patients, but is harmful to fetal and maternal health. A 26 years-old pregnant woman was admitted at 37 weeks gestation because of progressive generalized weakness, anorexia and weight loss. Initial physical examination reveals that she had been dehydrated, and blood pressure 130/80 mmHg, pulse rate 100/min, respiratory rate 20/min, and body temperature was 36.9 degrees C. Serum glucose was 545 mg/dL, pH 7.282, HCO3- 10.5 mmol/L, urine ketone 3+, urine glucose 2+ when initial laboratory work was done. She was treated with intravenous fluid and insulin under the impression of diabetic ketoacidosis. Her delivery was performed after 24 hours from admission because of suggestive fetal distress. After recovery, she is being treated with insulin at outpatient department. We experienced a appropriately treated case of diabetic ketoacidosis in pregnant woman with GDM, and report it with a literature review.

First
Prev
Page of 1
Next
Last

Search