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Original Article
- Cardiovascular Risk/Epidemiology
- Prognostic Value of Plasma Endothelin-1 in Predicting Worse Outcomes in Patients with Prediabetes and Diabetes and Stable Coronary Artery Diseases
- Cheng Yang, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Rui-Xia Xu, Yong-Jian Wu, Jie Qian, Jian-Jun Li
- Diabetes Metab J. 2024;48(5):993-1002. Published online August 21, 2024
- DOI: https://doi.org/10.4093/dmj.2023.0410
- 4,456 View
- 155 Download
- 5 Web of Science
- 7 Crossref
-
Abstract
PDF
Supplementary Material
PubReader 
ePub - Background
Endothelin-1 (ET-1) is an endogenous vasoconstrictor implicated in coronary artery disease (CAD) and diabetes. This study aimed to determine the prognostic value of ET-1 in the patients with stable CAD under different glucose metabolism states.
Methods
In this prospective, large-cohort study, we consecutively enrolled 7,947 participants with angiography-diagnosed stable CAD from April 2011 to April 2017. Patients were categorized by baseline glycemic status into three groups (normoglycemia, prediabetes, and diabetes) and further divided into nine groups by circulating ET-1 levels. Patients were followed for the occurrence of cardiovascular events (CVEs), including nonfatal myocardial infarction, stroke, and cardiovascular mortality.
Results
Of the 7,947 subjects, 3,352, 1,653, and 2,942 had normoglycemia, prediabetes, and diabetes, respectively. Over a median follow-up of 37.5 months, 381 (5.1%) CVEs occurred. The risk for CVEs was significantly higher in patients with elevated ET-1 levels after adjustment for potential confounders. When patients were categorized by both status of glucose metabolism and plasma ET-1 levels, the high ET-1 levels were associated with higher risk of CVEs in prediabetes (adjusted hazard ratio [HR], 2.089; 95% confidence interval [CI], 1.151 to 3.793) and diabetes (adjusted HR, 2.729; 95% CI, 1.623 to 4.588; both P<0.05).
Conclusion
The present study indicated that baseline plasma ET-1 levels were associated with the prognosis in prediabetic and diabetic patients with stable CAD, suggesting that ET-1 may be a valuable predictor in CAD patients with impaired glucose metabolism. -
Citations
Citations to this article as recorded by
- Endothelin-1 as dual marker for renal function decline and associated cardiovascular complications in patients with chronic kidney disease
Laura González-Rodríguez, Manuel Martí-Antonio, Sonia Mota-Zamorano, Celia Chicharro, Bárbara Cancho, Enrique Luna, Álvaro Álvarez, Zoraida Verde, Fernando Bandrés, Nicolás R Robles, Guillermo Gervasini
European Journal of Internal Medicine.2026; 144: 106542. CrossRef - Diagnostic Potential of Metabolomic and Proteomic Biomarkers in Cardiology—A Narrative Review
Lazzat Zhussupbekova, Dinara Nurkina, Gyulnar Zhussupova, Aliya Smagulova, Venera Rakhmetova, Elmira Akhmedyarova, Aisha Darybayeva, Klara Kurmangaliyeva, Ilya Kukes
Biomedicines.2026; 14(2): 257. CrossRef - Reduced abundance of Fusobacterium signifies cardiovascular benefits of sodium glucose cotransporter 2 inhibitor in type 2 diabetes: a single arm clinical trial
Shuhui Yang, Jiankun Deng, Xiaoxu Weng, Zhaojie Ma, Nie Lin, Yili Xiao, Rui Zuo, Yufei Hu, Canbin Zheng, Xiaoshan Zeng, Qimao Lin, Kaijian Hou
Frontiers in Pharmacology.2025;[Epub] CrossRef - Endothelin-1 and diabetes mellitus-induced erectile dysfunction: from pathogenesis to therapeutic potential
Hui Chen, Zixiang Gao, Xiangfa Lin, Huanan Zhang, Weidong Feng, Jiaqi Yang, Junlong Feng, Jisheng Wang, Bin Wang, Liang Han
Diabetes Research and Clinical Practice.2025; 226: 112352. CrossRef - The Role of Endothelin‐1, Kidney Function and Diabetes in Patients With Coronary Artery Disease Underwent Percutaneous Coronary Intervention
Zixiang Ye, Enmin Xie, Yuan Du, Wenjia Zhang, Kefei Dou
Journal of Diabetes.2025;[Epub] CrossRef - Chemerin Is the Adipokine Linked with Endothelin-Dependent Vasoconstriction in Human Obesity
Francesca Schinzari, Rossella Montenero, Carmine Cardillo, Manfredi Tesauro
Biomedicines.2025; 13(9): 2131. CrossRef - Potential Molecular Biomarkers for Predicting and Monitoring Complications in Type 2 Diabetes Mellitus
Zia Shariat-Madar, Fakhri Mahdi
Molecules.2025; 30(22): 4448. CrossRef
- Endothelin-1 as dual marker for renal function decline and associated cardiovascular complications in patients with chronic kidney disease
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