Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal



Page Path
HOME > Search
1 "Ronald Ma"
Article category
Publication year
Original Article
Chronic Kidney Disease and Associated Cardiovascular Risk Factors in Chinese with Type 2 Diabetes
Qing-Lin Lou, Xiao-Jun Ouyang, Liu-Bao Gu, Yong-Zhen Mo, Ronald Ma, Jennifer Nan, Alice Kong, Wing-Yee So, Gary Ko, Juliana Chan, Chun-Chung Chow, Rong-Wen Bian
Diabetes Metab J. 2012;36(6):433-442.   Published online December 12, 2012
  • 3,686 View
  • 42 Download
  • 25 Crossref
AbstractAbstract PDFPubReader   

To determine the frequency of chronic kidney disease (CKD) and its associated risk factors in Chinese type 2 diabetic patients, we conducted a cross-sectional study in Nanjing, China, in the period between January 2008 and December 2009.


Patients with type 2 diabetes under the care by Jiangsu Province Official Hospital, Nanjing, China were invited for assessment. CKD was defined as the presence of albuminuria or estimated glomerular filtration rate <60 mL/min/1.73 m2. Albuminuria was defined as urinary albumin-to-creatinine ratio ≥30 mg/g.


We recruited 1,521 urban Chinese patients with type 2 diabetes (mean age, 63.9±12.0 years). The frequency of CKD and albuminuria was 31.0% and 28.9%, respectively. After adjusted by age and sex, hypertension, anemia and duration of diabetes were significantly associated with CKD with odds ratio (95% confidence interval) being 1.93 (1.28 to 2.93), 1.70 (1.09 to 2.64), and 1.03 (1.00 to 1.06), respectively.


In conclusion, CKD was common in the urban Nanjing Chinese with type 2 diabetes. Strategies to prevent or delay progression of kidney disease in diabetes should be carried out at the early disease course of type 2 diabetes.


Citations to this article as recorded by  
  • Associations between dietary patterns and renal impairment in individuals with diabetes: a cross‐sectional study
    Ziling Ding, Xingzhe Wu, Chao Liu, Ruixue Ying, Yi Zhang, Shiqi Zhang, Qiu Zhang, Honglin Hu, Fang Dai
    Journal of Human Nutrition and Dietetics.2024; 37(1): 193.     CrossRef
  • A Randomised Controlled Study of Can Ling Bai Shu San Combined with Guizhi Fuling Pills and Dagliflozin in the Treatment of Proteinuria in Type 2 Diabetic Nephropathy Stage IV
    杰 张
    Advances in Clinical Medicine.2024; 14(01): 1829.     CrossRef
  • Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine
    Yi-lun Qu, Zhe-yi Dong, Hai-mei Cheng, Qian Liu, Qian Wang, Hong-tao Yang, Yong-hui Mao, Ji-jun Li, Hong-fang Liu, Yan-qiu Geng, Wen Huang, Wen-hu Liu, Hui-di Xie, Fei Peng, Shuang Li, Shuang-shuang Jiang, Wei-zhen Li, Shu-wei Duan, Zhe Feng, Wei-guang Zh
    Chinese Journal of Integrative Medicine.2023; 29(4): 308.     CrossRef
  • Extracellular status of thrombospondin-2 in type 2 diabetes mellitus and utility as a biomarker in the determination of early diabetic kidney disease
    Zhenzhen Lin, Didong Zhang, Xinxin Zhang, Wanxie Guo, Wenjun Wang, Yingchao Zhang, Zhen Liu, Yanxue Bi, Maolan Wu, Zhuofeng Lin, Xuemian Lu
    BMC Nephrology.2023;[Epub]     CrossRef
  • Serum Lipocalin-2 Levels Are Increased and Independently Associated With Early-Stage Renal Damage and Carotid Atherosclerotic Plaque in Patients With T2DM
    Jing Gan, Yu Zheng, Qiongli Yu, Yingchao Zhang, Wei Xie, Yaru Shi, Ning Yu, Yu Yan, Zhuofeng Lin, Hong Yang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The Prevalence, Progress and Risk Factor Control of Chronic Kidney Disease in Chinese Adults With Type 2 Diabetes Mellitus in Primary Care
    Lingwang An, Qiuzhi Yu, Hong Tang, Xianglan Li, Dandan Wang, Qi Tang, Haiyang Xing, Yali He, Xiaona Zhao, Shuhui Zhao, Yaujiunn Lee, Juming Lu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Hydration status according to impedance vectors and its association with clinical and biochemical outcomes and mortality in patients with chronic kidney disease
    Paola Vanessa Miranda Alatriste, Eloísa Colin Ramírez, Ximena Atilano Carsi, Cristino Cruz-Rivera, Ángeles Espinosa-Cuevas
    Nutrición Hospitalaria.2022;[Epub]     CrossRef
  • The Prevalence of Diabetic Microvascular Complications in China and the USA
    Yu Kuei Lin, Bixia Gao, Lili Liu, Lynn Ang, Kara Mizokami-Stout, Rodica Pop-Busui, Luxia Zhang
    Current Diabetes Reports.2021;[Epub]     CrossRef
  • Reno-protective potential of sodium glucose cotransporter-2 (SGLT2) inhibitors: Summary evidence from clinical and real-world data
    Niti Mittal, Vikas Sehray, Rakesh Mittal, Surjit Singh
    European Journal of Pharmacology.2021; 907: 174320.     CrossRef
  • Association between Renal Podocalyxin Expression and Renal Dysfunction in Patients with Diabetic Nephropathy: A Single-Center, Retrospective Case-Control Study
    Rongzhen Wang, Can Yao, Feng Liu
    BioMed Research International.2020; 2020: 1.     CrossRef
  • Renoprotection with SGLT2 inhibitors in type 2 diabetes over a spectrum of cardiovascular and renal risk
    Francesco Giorgino, Jiten Vora, Peter Fenici, Anna Solini
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Prevalence of diabetic nephropathy among Chinese patients with type 2 diabetes mellitus and different categories of their estimated glomerular filtration rate based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in primary car
    Ka Yee Mok, Pang Fai Chan, Loretta K. P. Lai, Kai Lim Chow, David V. K. Chao
    Journal of Diabetes & Metabolic Disorders.2019; 18(2): 281.     CrossRef
  • The association between serum uric acid to creatinine ratio and renal disease progression in type 2 diabetic patients in Chinese communities
    Yao Chunlei, Gu Liubao, Wang Tao, Xing Changying
    Journal of Diabetes and its Complications.2019; 33(7): 473.     CrossRef
  • Risk factors of chronic kidney diseases in Chinese adults with type 2 diabetes
    Lin Yang, Tsun Kit Chu, Jinxiao Lian, Cheuk Wai Lo, Pak Ki Lau, Hairong Nan, Jun Liang
    Scientific Reports.2018;[Epub]     CrossRef
  • Any grade of relative overhydration is associated with long-term mortality in patients with Stages 4 and 5 non-dialysis chronic kidney disease
    Almudena Vega, Soraya Abad, Nicolás Macías, Inés Aragoncillo, Ana García-Prieto, Tania Linares, Esther Torres, Andrés Hernández, José Luño
    Clinical Kidney Journal.2018; 11(3): 372.     CrossRef
  • The impact of the quality of care and other factors on progression of chronic kidney disease in Thai patients with Type 2 Diabetes Mellitus: A nationwide cohort study
    Paithoon Sonthon, Supannee Promthet, Siribha Changsirikulchai, Ram Rangsin, Bandit Thinkhamrop, Suthee Rattanamongkolgul, Cameron P. Hurst, Cheng Hu
    PLOS ONE.2017; 12(7): e0180977.     CrossRef
  • Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus
    Xue Sun, Jie He, Xiao-Li Ji, Yi-Ming Zhao, Han-Yu Lou, Xiao-Xiao Song, Li-Zhen Shan, Ying-Xiu Kang, Wen-Heng Zeng, Xiao-Hong Pang, Song-Zhao Zhang, Yue Ding, Yue-Zhong Ren, Peng-Fei Shan
    Chinese Medical Journal.2017; 130(1): 57.     CrossRef
  • Prevalence of chronic kidney disease and associated factors in Chinese individuals with type 2 diabetes: Cross-sectional study
    Kaifeng Guo, Lei Zhang, Fangya Zhao, Junxi Lu, Pan Pan, Haoyong Yu, Yuqian Bao, Haibing Chen, Weiping Jia
    Journal of Diabetes and its Complications.2016; 30(5): 803.     CrossRef
  • The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
    Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
    Diabetes Research and Clinical Practice.2015; 108(1): 31.     CrossRef
  • Association of elevated glycosylated hemoglobin A1c with hyperfiltration in a middle-aged and elderly Chinese population with prediabetes or newly diagnosed diabetes: a cross-sectional study
    Wen Hu, Hairong Hao, Weinan Yu, Xiaojuan Wu, Hongwen Zhou
    BMC Endocrine Disorders.2015;[Epub]     CrossRef
  • Prevalence of Chronic Kidney Disease in Adults with Type 2 Diabetes Mellitus
    Serena KM Low, Chee Fang Sum, Lee Ying Yeoh, Subramaniam Tavintharan, Xiao Wei Ng, Simon BM Lee, Wern Ee Tang, Su Chi Lim
    Annals of the Academy of Medicine, Singapore.2015; 44(5): 164.     CrossRef
  • Low Ankle-Brachial Index Is Associated with Early-Stage Chronic Kidney Disease in Type 2 Diabetic Patients Independent of Albuminuria
    Xuehong Dong, Dingting Wu, Chengfang Jia, Yu Ruan, Xiaocheng Feng, Guoxing Wang, Jun Liu, Yi Shen, Hong Li, Lianxi Li, Karin Jandeleit-Dahm
    PLoS ONE.2014; 9(10): e109641.     CrossRef
  • Health Behaviors and Risk Factors Associated with Chronic Kidney Disease in Korean Patients with Diabetes: The Fourth Korean National Health and Nutritional Examination Survey
    Suk Jeong Lee, Chae Weon Chung
    Asian Nursing Research.2014; 8(1): 8.     CrossRef
  • Urinary miR-29 Correlates with Albuminuria and Carotid Intima-Media Thickness in Type 2 Diabetes Patients
    Hui Peng, Meirong Zhong, Wenbo Zhao, Cheng Wang, Jun Zhang, Xun Liu, Yuanqing Li, Sujay Dutta Paudel, Qianqian Wang, Tanqi Lou, Emmanuel A. Burdmann
    PLoS ONE.2013; 8(12): e82607.     CrossRef
  • Diabetes and its comorbidities—where East meets West
    Alice P. S. Kong, Gang Xu, Nicola Brown, Wing-Yee So, Ronald C. W. Ma, Juliana C. N. Chan
    Nature Reviews Endocrinology.2013; 9(9): 537.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal