Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
2 "Masayuki Saito"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Reviews
Basic Research
Article image
Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
Okamatsu-Ogura Yuko, Masayuki Saito
Diabetes Metab J. 2021;45(6):840-852.   Published online June 25, 2021
DOI: https://doi.org/10.4093/dmj.2020.0291
  • 10,559 View
  • 596 Download
  • 24 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.

Citations

Citations to this article as recorded by  
  • Garlic ( Allium sativum L. ) in diabetes and its complications: Recent advances in mechanisms of action
    Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
    Critical Reviews in Food Science and Nutrition.2024; 64(16): 5290.     CrossRef
  • Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
    Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues
    Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri, Masoud Darabi
    Biochemical Pharmacology.2024; 220: 116012.     CrossRef
  • Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
    Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza‐Mello, Julio Beltrame Daleprane
    Molecular Nutrition & Food Research.2024;[Epub]     CrossRef
  • Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis
    Yanqiu Peng, Lixia Zhao, Min Li, Yunfei Liu, Yuke Shi, Jian Zhang
    Biomolecules.2024; 14(4): 483.     CrossRef
  • Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes
    Kiros Haddish, Jong Won Yun
    Biotechnology and Bioprocess Engineering.2024; 29(4): 673.     CrossRef
  • The role of brown adipose tissue in mediating healthful longevity
    Jie Zhang, Berhanu Geresu Kibret, Dorothy E. Vatner, Stephen F. Vatner
    The Journal of Cardiovascular Aging.2024;[Epub]     CrossRef
  • Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats
    Lili Guan, Lei Zhang, Dezheng Gong, Pengcheng Li, Shengnan Zhu, Jiulan Tang, Man Du, Maokun Zhang, Yuan Zou
    Journal of Pharmacy and Pharmacology.2024; 76(7): 897.     CrossRef
  • N-3 polyunsaturated fatty acids in fat-1 transgenic mice prevent obesity by stimulating the IL-27 signaling pathway
    Jiayao Bai, Yinlin Ge, Changqi Zhao, Liu Yang, Keli Ge, Jinyu Zhang
    Journal of Functional Foods.2024; 118: 106288.     CrossRef
  • Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly
    Estevão Carlos Silva Barcelos, Michel Satya Naslavsky, Izadora Silveira Fernandes, Marilia Oliveira Scliar, Guilherme Lopes Yamamoto, Jaqueline Yu Ting Wang, Laís Bride, Valdemir Pereira de Sousa, Lucia Helena Sagrillo Pimassoni, Paolo Sportoletti, Flavia
    Scientific Reports.2024;[Epub]     CrossRef
  • The Metabolic Syndrome: An Overview and Proposed Mechanisms
    Fernanda Santos Thomaz, Oliver Dean John, Payel Sinha, Siti Raihanah Shafie, Simon Worrall
    Obesities.2024; 4(3): 226.     CrossRef
  • A Closer Look into White Adipose Tissue Biology and the Molecular Regulation of Stem Cell Commitment and Differentiation
    Presley D. Dowker-Key, Praveen Kumar Jadi, Nicholas B. Gill, Katelin N. Hubbard, Ahmed Elshaarrawi, Naba D. Alfatlawy, Ahmed Bettaieb
    Genes.2024; 15(8): 1017.     CrossRef
  • Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model
    Melina Amor, Malena Diaz, Valentina Bianco, Monika Svecla, Birgit Schwarz, Silvia Rainer, Anita Pirchheim, Laszlo Schooltink, Suravi Mukherjee, Gernot F. Grabner, Giangiacomo Beretta, Claudia Lamina, Giuseppe Danilo Norata, Hubert Hackl, Dagmar Kratky
    Cardiovascular Diabetology.2024;[Epub]     CrossRef
  • Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
    Masayuki Saito, Yuko Okamatsu-Ogura
    The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
  • Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
    Min Jeong Park, Kyung Mook Choi
    Metabolism.2023; 144: 155577.     CrossRef
  • White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
    Anju Tsukada, Yuko Okamatsu-Ogura, Emi Futagawa, Yuki Habu, Natsumi Takahashi, Mira Kato-Suzuki, Yuko Kato, Satoshi Ishizuka, Kei Sonoyama, Kazuhiro Kimura
    iScience.2023; 26(7): 107239.     CrossRef
  • In situ fluorescence-photoacoustic measurement of the changes of brown adipose tissue in mice under hindlimb unloading
    Baojie Gong, Jianxin Tang, Xiaoxiao Jiang, Zhe Zhang, Shiying Li, Hongjun Jin, Liming Nie, Guojia Huang
    Journal of Applied Physiology.2023; 135(2): 251.     CrossRef
  • Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
    A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
    Journal of Evolutionary Biochemistry and Physiology.2023; 59(4): 1020.     CrossRef
  • UNCOUPLING PROTEIN UCP1 EXPRESSION DYNAMICS IN ADIPOSE TISSUES OF THE OUTBRED ICR MICE IN POSTNATAL ONTOGENESIS
    A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
    Журнал эволюционной биохимии и физиологии.2023; 59(4): 255.     CrossRef
  • Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis
    Sunghyun Kang, Hwan-Woo Park, Kyung Ho Han
    International Journal of Molecular Sciences.2022; 23(14): 7834.     CrossRef
  • Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
    Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Possible roles of exercise and apelin against pregnancy complications
    Hamed Alizadeh Pahlavani
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Relationships between the expression of adipose genes and profiles of hospitalized dogs
    Yukina Sugiyama, Fumie Shimokawa, Kazutoshi Sugiyama, Takashi Kobayashi, Yusuke Yamashita, Kei Kazama, Ken Onda, Masayuki Funaba, Masaru Murakami
    Veterinary Research Communications.2022; 46(4): 1239.     CrossRef
  • Fruit of Gardenia jasminoides Induces Mitochondrial Activation and Non-Shivering Thermogenesis through Regulation of PPARγ
    Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
    Antioxidants.2021; 10(9): 1418.     CrossRef
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Masayuki Saito
Diabetes Metab J. 2013;37(1):22-29.   Published online February 15, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.1.22
  • 6,553 View
  • 92 Download
  • 95 Crossref
AbstractAbstract PDFPubReader   

Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.

Citations

Citations to this article as recorded by  
  • Taraxacum mongolicum polysaccharide promotes white adipocyte browning by regulating miR-134-3p via Akt/GSK-3β signalling
    Xiaoyu Yue, Ling Zhong, Mengyan Ye, Yue Luan, Qiang Zhang, Qin Wang
    International Journal of Biological Macromolecules.2024; 257: 128296.     CrossRef
  • Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
    Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
    Journal of Biophotonics.2024;[Epub]     CrossRef
  • Nuciferine prevents obesity by activating brown adipose tissue
    Chunlong Yan, Yang Zhan, Shouli Yuan, Yujing Cao, Yi Chen, Meng Dong, Hanlin Zhang, Li Chen, Rui Jiang, Wenjun Liu, Wanzhu Jin, Yuanyuan Huang
    Food & Function.2024; 15(2): 967.     CrossRef
  • Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes—Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy
    Gonçalo Ferreira, Pedro Vieira, André Alves, Sara Nunes, Inês Preguiça, Tânia Martins-Marques, Tânia Ribeiro, Henrique Girão, Artur Figueirinha, Lígia Salgueiro, Manuela Pintado, Pedro Gomes, Sofia Viana, Flávio Reis
    Nutrients.2024; 16(4): 513.     CrossRef
  • Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism
    Alexis Diaz-Vegas, Kristen C. Cooke, Harry B. Cutler, Belinda Yau, Stewart W.C. Masson, Dylan Harney, Oliver K. Fuller, Meg Potter, Søren Madsen, Niamh R. Craw, Yiju Zhang, Cesar L. Moreno, Melkam A. Kebede, G. Gregory Neely, Jacqueline Stöckli, James G.
    Molecular Metabolism.2024; 86: 101983.     CrossRef
  • Thermal Regulation and the Nervous System
    Kee Hong Park
    Korean Journal of Neuromuscular Disorders.2024; 16(1): 1.     CrossRef
  • Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1−/− Mice
    Filippo Molica, Avigail Ehrlich, Graziano Pelli, Olga M. Rusiecka, Christophe Montessuit, Marc Chanson, Brenda R. Kwak
    Biomolecules.2024; 14(9): 1058.     CrossRef
  • Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice
    Abigail M. Benvie, Daniel C. Berry
    Molecular Metabolism.2024; 89: 102028.     CrossRef
  • CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury
    Matthieu Leuillier, Thomas Duflot, Séverine Ménoret, Hind Messaoudi, Zoubir Djerada, Déborah Groussard, Raphaël G.P. Denis, Laurence Chevalier, Ahmed Karoui, Baptiste Panthu, Pierre-Alain Thiébaut, Isabelle Schmitz-Afonso, Séverine Nobis, Cynthia Campart,
    Journal of Advanced Research.2023; 43: 163.     CrossRef
  • Metabolic effects of lipectomy and of adipose tissue transplantation
    Sarah Davis, Samantha Hocking, Matthew J. Watt, Jenny E. Gunton
    Obesity.2023; 31(1): 7.     CrossRef
  • Modulation of the thermosensory system by oxytocin
    Ugo Zayan, Laura Caccialupi Da Prato, Françoise Muscatelli, Valéry Matarazzo
    Frontiers in Molecular Neuroscience.2023;[Epub]     CrossRef
  • Regenerative Medicine for Polycystic Ovary Syndrome: Stem Cell-Based Therapies and Brown Adipose Tissue Activation
    Mario Karam, Hélène Najjar, Marwan El Sabban, Aline Hamade, Fadia Najjar
    Stem Cell Reviews and Reports.2023; 19(4): 853.     CrossRef
  • Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
    Masayuki Saito, Yuko Okamatsu-Ogura
    The World Journal of Men's Health.2023; 41(3): 489.     CrossRef
  • p27Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice
    Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, María Collantes, Philipp Kaldis, José Alfredo Martinez, Gema Medina-Gómez, María Jesús Moreno-Aliaga, Xavier Escoté
    International Journal of Molecular Sciences.2023; 24(3): 2664.     CrossRef
  • Energy metabolism and thermoregulation during sleep in young and old females
    Jaehoon Seol, Chihiro Kokudo, Insung Park, Simeng Zhang, Katsuhiko Yajima, Tomohiro Okura, Kumpei Tokuyama
    Scientific Reports.2023;[Epub]     CrossRef
  • Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model
    Marcos David Munoz, Alexa Zamudio, Maximilian McCann, Victoria Gil, Pingwen Xu, Chong Wee Liew
    Scientific Reports.2023;[Epub]     CrossRef
  • Ado-Mediated Depletion of Taurine Impairs Mitochondrial Respiratory Capacity and Alters the Chromatin Landscape of Inguinal Adipose Tissue
    Pei-Yin Tsai, Bo Shui, Seoyeon Lee, Yang Liu, Yue Qu, Chloe Cheng, Kaydine Edwards, Callie Wong, Ryan Meng-Killeen, Paul D. Soloway, Joeva J. Barrow
    Nutrients.2023; 15(16): 3532.     CrossRef
  • Metabolic associated fatty liver disease is a disease related to sympathetic nervous system activation
    Zhao-Chun Chi
    World Chinese Journal of Digestology.2022; 30(11): 465.     CrossRef
  • Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy
    Stefan Tholen, Roma Patel, Agnieszka Agas, Kyle M. Kovary, Atefeh Rabiee, Hayley T. Nicholls, Ewa Bielczyk-Maczyńska, Wenting Yang, Fredric B. Kraemer, Mary N. Teruel
    Cell Reports.2022; 39(13): 111018.     CrossRef
  • KLHL3 deficiency in mice ameliorates obesity, insulin resistance, and nonalcoholic fatty liver disease by regulating energy expenditure
    Ju-hong Jang, Jeong Woong Lee, Min Ji Cho, Byungtae Hwang, Min-Gi Kwon, Dong-Hwan Kim, Nam-Kyung Lee, Jangwook Lee, Young-Jun Park, Yong Ryoul Yang, Jinchul Kim, Yong-Hoon Kim, Tae Hyeon An, Kyoung-Jin Oh, Kwang-Hee Bae, Jong-Gil Park, Jeong-Ki Min
    Experimental & Molecular Medicine.2022; 54(8): 1250.     CrossRef
  • Brown fat-associated postprandial thermogenesis in humans: Different effects of isocaloric meals rich in carbohydrate, fat, and protein
    Sayuri Aita, Mami Matsushita, Takeshi Yoneshiro, Takuya Hatano, Toshimitsu Kameya, Iwao Ohkubo, Masayuki Saito
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans
    Anna Borup, Ida Donkin, Mariëtte R. Boon, Martin Frydland, Borja Martinez-Tellez, Annika Loft, Sune H. Keller, Andreas Kjaer, Jesper Kjaergaard, Christian Hassager, Romain Barrès, Patrick C. N. Rensen, Christina Christoffersen
    Scientific Reports.2022;[Epub]     CrossRef
  • Signaling Pathways Regulating Thermogenesis
    Chihiro Tabuchi, Hei Sook Sul
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice
    Yejin Jeon, Ji-Young Choi, Eun-Hwa Jang, Je Kyung Seong, Kyunglim Lee
    International Journal of Obesity.2021; 45(7): 1576.     CrossRef
  • Diurnal variations of brown fat thermogenesis and fat oxidation in humans
    Mami Matsushita, Shinsuke Nirengi, Masanobu Hibi, Hitoshi Wakabayashi, Sang-il Lee, Masayuki Domichi, Naoki Sakane, Masayuki Saito
    International Journal of Obesity.2021; 45(11): 2499.     CrossRef
  • Adipose browning response to burn trauma is impaired with aging
    Abdikarim Abdullahi, Carly M. Knuth, Christopher Auger, Thibacg Sivayoganathan, Alexandra Parousis, Marc G. Jeschke
    JCI Insight.2021;[Epub]     CrossRef
  • The Effect of Hyperbaric Therapy on Brown Adipose Tissue in Rats
    Chang-Hyung Lee, Young-A Choi, Sung-Jin Heo, Parkyong Song
    International Journal of Environmental Research and Public Health.2021; 18(17): 9165.     CrossRef
  • Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
    Okamatsu-Ogura Yuko, Masayuki Saito
    Diabetes & Metabolism Journal.2021; 45(6): 840.     CrossRef
  • Comparative Transcriptome Profiling of Young and Old Brown Adipose Tissue Thermogenesis
    Yumin Kim, Baeki E. Kang, Dongryeol Ryu, So Won Oh, Chang-Myung Oh
    International Journal of Molecular Sciences.2021; 22(23): 13143.     CrossRef
  • Supplementation of polar lipids‐enriched milk fat globule membrane in high‐fat diet‐fed rats during pregnancy and lactation promotes brown/beige adipocyte development and prevents obesity in male offspring
    Tiange Li, Han Gong, Qichen Yuan, Min Du, Fazheng Ren, Xueying Mao
    The FASEB Journal.2020; 34(3): 4619.     CrossRef
  • Nicotine exposure during breastfeeding reduces sympathetic activity in brown adipose tissue and increases in white adipose tissue in adult rats: Sex-related differences
    T.C. Peixoto, E.G. Moura, P.N. Soares, I.M. Bertasso, C.B. Pietrobon, F.A.H. Caramez, R.A. Miranda, E. Oliveira, A.C. Manhães, P.C. Lisboa
    Food and Chemical Toxicology.2020; 140: 111328.     CrossRef
  • Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice
    Caryn Carson, Juan F. Macias-Velasco, Subhadra Gunawardana, Mario A. Miranda, Sakura Oyama, Celine L. St. Pierre, Heather Schmidt, Jessica P. Wayhart, Heather A. Lawson
    Cell Reports.2020; 33(1): 108237.     CrossRef
  • Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via β3-adrenergic Receptor-p38 MAPK Signaling Pathway
    Subramani Manigandan, Jong Won Yun
    Biotechnology and Bioprocess Engineering.2020; 25(3): 345.     CrossRef
  • Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men
    Masayuki Saito, Mami Matsushita, Takeshi Yoneshiro, Yuko Okamatsu-Ogura
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Differences in [18F]FDG uptake in BAT of UCP1 −/− and UCP1 +/+ during adrenergic stimulation of non-shivering thermogenesis
    Christian T. McHugh, John Garside, Jared Barkes, Jonathan Frank, Constance Dragicevich, Hong Yuan, Rosa T. Branca
    EJNMMI Research.2020;[Epub]     CrossRef
  • Glucocorticoids and Brown Adipose Tissue: Do glucocorticoids really inhibit thermogenesis?
    Ineke H.N. Luijten, Barbara Cannon, Jan Nedergaard
    Molecular Aspects of Medicine.2019; 68: 42.     CrossRef
  • Sexual Dimorphism of Brown Adipose Tissue Function
    Lindsay J. Robinson, James Law, Valerie Astle, Marta Gutiérrez-García, Shalini Ojha, Michael E. Symonds, Nicola Pitchford, Helen Budge
    The Journal of Pediatrics.2019; 210: 166.     CrossRef
  • Cold Induced Depot-Specific Browning in Ferret Aortic Perivascular Adipose Tissue
    Bàrbara Reynés, Evert M. van Schothorst, Jaap Keijer, Enzo Ceresi, Paula Oliver, Andreu Palou
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism
    Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi, Shimpei Ushio
    Nutrition & Metabolism.2019;[Epub]     CrossRef
  • Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice
    Gabriela Cavazza Cerri, Leandro Ceotto Freitas Lima, Deborah de Farias Lelis, Lucíola da Silva Barcelos, John David Feltenberger, Samuel Vidal Mussi, Renato Sobral Monteiro-Junior, Robson Augusto Souza dos Santos, Lucas Antônio Miranda Ferreira, Sérgio He
    Life Sciences.2019; 218: 292.     CrossRef
  • Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway
    Qinyang Jiang, Xiaofang Cheng, Yueyue Cui, Qin Xia, Xueyu Yan, Mingyuan Zhang, Ganqiu Lan, Jiaqi Liu, Tizhong Shan, Yanna Huang
    Food & Function.2019; 10(6): 3334.     CrossRef
  • Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines
    Yea Eun Kang, Hyun Jin Kim, Minho Shong
    Diabetes & Metabolism Journal.2019; 43(5): 549.     CrossRef
  • Inter‐organ communication: a gatekeeper for metabolic health
    Judit Castillo‐Armengol, Lluis Fajas, Isabel C Lopez‐Mejia
    EMBO reports.2019;[Epub]     CrossRef
  • Clinical Implications of UCP1 mRNA Expression in Human Cervical Adipose Tissue Under Physiological Conditions
    Ju Hee Lee, Ji Min Kim, Min Jeong Choi, Yea Eun Kang, Kyoung Hye Joung, Hyon‐Seung Yi, Koon Soon Kim, Bon Jeong Ku, Bon Seok Koo, Minho Shong, Hyun Jin Kim
    Obesity.2018; 26(6): 1008.     CrossRef
  • Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance
    Kenneth D’Souza, Geena Paramel, Petra Kienesberger
    Nutrients.2018; 10(4): 399.     CrossRef
  • Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity
    Clément Pierre, Florent Guillebaud, Coraline Airault, Nathalie Baril, Rym Barbouche, Etienne Save, Stéphanie Gaigé, Bruno Bariohay, Michel Dallaporta, Jean-Denis Troadec
    Frontiers in Physiology.2018;[Epub]     CrossRef
  • Bovine lactoferrin promotes energy expenditure via the cAMP-PKA signaling pathway in human reprogrammed brown adipocytes
    Kanae Nakamura, Tsunao Kishida, Akika Ejima, Riho Tateyama, Satoru Morishita, Tomoji Ono, Michiaki Murakoshi, Keikichi Sugiyama, Hoyoku Nishino, Osam Mazda
    BioMetals.2018; 31(3): 415.     CrossRef
  • Association of wrist and ambient temperature with cold-induced brown adipose tissue and skeletal muscle [18F]FDG uptake in young adults
    Borja Martinez-Tellez, Huiwen Xu, Guillermo Sanchez-Delgado, Francisco M. Acosta, Patrick C. N. Rensen, Jose M. Llamas-Elvira, Jonatan R. Ruiz
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2018; 315(6): R1281.     CrossRef
  • Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
    Yongguo Li, Katharina Schnabl, Sarah-Madeleine Gabler, Monja Willershäuser, Josefine Reber, Angelos Karlas, Sanna Laurila, Minna Lahesmaa, Mueez u Din, Andrea Bast-Habersbrunner, Kirsi A. Virtanen, Tobias Fromme, Florian Bolze, Libbey S. O’Farrell, Jorge
    Cell.2018; 175(6): 1561.     CrossRef
  • Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
    G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
    International Journal of Obesity.2018; 42(3): 542.     CrossRef
  • Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans
    Daniel C. Berry, Yuwei Jiang, Robert W. Arpke, Elizabeth L. Close, Aki Uchida, David Reading, Eric D. Berglund, Michael Kyba, Jonathan M. Graff
    Cell Metabolism.2017; 25(1): 166.     CrossRef
  • Postprandial Increase in Energy Expenditure Correlates with Body Weight Reduction in Patients with Type 2 Diabetes Receiving Diet Therapy
    Daisuke Sanoyama, Mototsugu Nagao, Akira Asai, Yuko Nakamura, Kazumi Sato, Yasushi Nakajima, Shinichi Oikawa, Hitoshi Sugihara
    Journal of Atherosclerosis and Thrombosis.2017; 24(4): 422.     CrossRef
  • Physiological regulation and metabolic role of browning in white adipose tissue
    Aleksandra Jankovic, Vesna Otasevic, Ana Stancic, Biljana Buzadzic, Aleksandra Korac, Bato Korac
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • Resveratrol enhances brown adipocyte formation and function by activating AMP‐activated protein kinase (AMPK) α1 in mice fed high‐fat diet
    Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
    Daniela Guarino, Monica Nannipieri, Giorgio Iervasi, Stefano Taddei, Rosa Maria Bruno
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • Adipoz doku ve enerji metabolizması üzerine etkileri
    Meltem Mermer, Nilüfer Acar TEK
    SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
  • Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans
    Takayuki Nishimura, Takafumi Katsumura, Midori Motoi, Hiroki Oota, Shigeki Watanuki
    Scientific Reports.2017;[Epub]     CrossRef
  • Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation
    Yuwei Jiang, Daniel C Berry, Jonathan M Graff
    eLife.2017;[Epub]     CrossRef
  • Ovarian hormones and obesity
    Brigitte Leeners, Nori Geary, Philippe N. Tobler, Lori Asarian
    Human Reproduction Update.2017; 23(3): 300.     CrossRef
  • Nutritional approaches for managing obesity-associated metabolic diseases
    Rachel Botchlett, Shih-Lung Woo, Mengyang Liu, Ya Pei, Xin Guo, Honggui Li, Chaodong Wu
    Journal of Endocrinology.2017; 233(3): R145.     CrossRef
  • Lower core body temperature and greater body fat are components of a human thrifty phenotype
    M Reinhardt, M Schlögl, S Bonfiglio, S B Votruba, J Krakoff, M S Thearle
    International Journal of Obesity.2016; 40(5): 754.     CrossRef
  • Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans
    Aleix Gavaldà-Navarro, José M. Moreno-Navarrete, Tania Quesada-López, Montserrat Cairó, Marta Giralt, José M. Fernández-Real, Francesc Villarroya
    Diabetologia.2016; 59(10): 2208.     CrossRef
  • Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function
    Daniel C. Berry, Yuwei Jiang, Jonathan M. Graff
    Nature Communications.2016;[Epub]     CrossRef
  • Control of human energy expenditure by cytochrome c oxidase subunit IV-2
    Tomas A. Schiffer, Maria Peleli, Michaela L. Sundqvist, Björn Ekblom, Jon O. Lundberg, Eddie Weitzberg, Filip J. Larsen
    American Journal of Physiology-Cell Physiology.2016; 311(3): C452.     CrossRef
  • Susceptibility of brown adipocytes to pro-inflammatory cytokine toxicity and reactive oxygen species
    Lars Rebiger, Sigurd Lenzen, Ilir Mehmeti
    Bioscience Reports.2016;[Epub]     CrossRef
  • Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
    Mark J.W. Hanssen, Anouk A.J.J. van der Lans, Boudewijn Brans, Joris Hoeks, Kelly M.C. Jardon, Gert Schaart, Felix M. Mottaghy, Patrick Schrauwen, Wouter D. van Marken Lichtenbelt
    Diabetes.2016; 65(5): 1179.     CrossRef
  • Phytochemicals as novel agents for the induction of browning in white adipose tissue
    Yusra Azhar, Ashish Parmar, Colette N. Miller, Janaiya S. Samuels, Srujana Rayalam
    Nutrition & Metabolism.2016;[Epub]     CrossRef
  • Energy expenditure and intake during puberty in healthy nonobese adolescents: a systematic review
    Hoi Lun Cheng, Mazen Amatoury, Katharine Steinbeck
    The American Journal of Clinical Nutrition.2016; 104(4): 1061.     CrossRef
  • MRI characterization of brown adipose tissue in obese and normal-weight children
    Jie Deng, Samantha E. Schoeneman, Huiyuan Zhang, Soyang Kwon, Cynthia K. Rigsby, Richard M. Shore, Jami L. Josefson
    Pediatric Radiology.2015; 45(11): 1682.     CrossRef
  • A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction
    Martin Reinhardt, Marie S. Thearle, Mostafa Ibrahim, Maximilian G. Hohenadel, Clifton Bogardus, Jonathan Krakoff, Susanne B. Votruba
    Diabetes.2015; 64(8): 2859.     CrossRef
  • Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
    S Wang, X Liang, Q Yang, X Fu, C J Rogers, M Zhu, B D Rodgers, Q Jiang, M V Dodson, M Du
    International Journal of Obesity.2015; 39(6): 967.     CrossRef
  • Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
    Masayuki Saito
    The Korean Journal of Obesity.2015; 24(1): 1.     CrossRef
  • Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes
    Colette N. Miller, Jeong-Yeh Yang, Emily England, Amelia Yin, Clifton A. Baile, Srujana Rayalam, Graça Soveral
    PLOS ONE.2015; 10(9): e0138344.     CrossRef
  • Carotenoids and their conversion products in the control of adipocyte function, adiposity and obesity
    M. Luisa Bonet, Jose A. Canas, Joan Ribot, Andreu Palou
    Archives of Biochemistry and Biophysics.2015; 572: 112.     CrossRef
  • Calorie hoarding and thrifting: Foxa3 finds a way
    Xinran Ma, Lingyan Xu, Elisabetta Mueller
    Adipocyte.2015; 4(4): 325.     CrossRef
  • Can thermogenic adipocytes protect from obesity?
    L. N. Medvedev, E. I. Elsukova
    Journal of Physiology and Biochemistry.2015; 71(4): 847.     CrossRef
  • Capsinoids suppress diet-induced obesity through uncoupling protein 1-dependent mechanism in mice
    Yuko Okamatsu-Ogura, Ayumi Tsubota, Kana Ohyama, Yoshihito Nogusa, Masayuki Saito, Kazuhiro Kimura
    Journal of Functional Foods.2015; 19: 1.     CrossRef
  • Energy Expenditure in Humans and Other Primates: A New Synthesis
    Herman Pontzer
    Annual Review of Anthropology.2015; 44(1): 169.     CrossRef
  • Gene expression of peripheral blood mononuclear cells is affected by cold exposure
    Bàrbara Reynés, Estefanía García-Ruiz, Paula Oliver, Andreu Palou
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2015; 309(8): R824.     CrossRef
  • Ambient Temperature and Prevalence of Obesity: A Nationwide Population-Based Study in Korea
    Hae Kyung Yang, Kyungdo Han, Jae-Hyoung Cho, Kun-Ho Yoon, Bong-Yun Cha, Seung-Hwan Lee, David Meyre
    PLOS ONE.2015; 10(11): e0141724.     CrossRef
  • Food Ingredients as Anti-Obesity Agents
    Masayuki Saito, Takeshi Yoneshiro, Mami Matsushita
    Trends in Endocrinology & Metabolism.2015; 26(11): 585.     CrossRef
  • Matured Hop Bittering Components Induce Thermogenesis in Brown Adipose Tissue via Sympathetic Nerve Activity
    Yumie Morimoto-Kobayashi, Kazuaki Ohara, Chika Takahashi, Sayoko Kitao, Guanying Wang, Yoshimasa Taniguchi, Mikio Katayama, Katsuya Nagai, Qinghua Sun
    PLOS ONE.2015; 10(6): e0131042.     CrossRef
  • Role of forkhead box protein A3 in age-associated metabolic decline
    Xinran Ma, Lingyan Xu, Oksana Gavrilova, Elisabetta Mueller
    Proceedings of the National Academy of Sciences.2014; 111(39): 14289.     CrossRef
  • Thermoneutrality results in prominent diet‐induced body weight differences in C57BL/6J mice, not paralleled by diet‐induced metabolic differences
    Femke P. M. Hoevenaars, Melissa Bekkenkamp‐Grovenstein, Rolf J. R. J. Janssen, Sandra G. Heil, Annelies Bunschoten, Elise F. Hoek‐van den Hil, Sophie Snaas‐Alders, Katja Teerds, Evert M. van Schothorst, Jaap Keijer
    Molecular Nutrition & Food Research.2014; 58(4): 799.     CrossRef
  • Vijftig tinten vet
    Mattees van Dijk
    Tijdschrift voor praktijkondersteuning.2014; 9(6): 170.     CrossRef
  • MRI detection of brown adipose tissue with low fat content in newborns with hypothermia
    Houchun H. Hu, Tai-Wei Wu, Larry Yin, Mimi S. Kim, Jonathan M. Chia, Thomas G. Perkins, Vicente Gilsanz
    Magnetic Resonance Imaging.2014; 32(2): 107.     CrossRef
  • The origin and definition of brite versus white and classical brown adipocytes
    Matthias Rosenwald, Christian Wolfrum
    Adipocyte.2014; 3(1): 4.     CrossRef
  • Expression of “brown-in-white” adipocyte biomarkers shows gender differences and the influence of early dietary exposure
    María Servera, Nora López, Francisca Serra, Andreu Palou
    Genes & Nutrition.2014;[Epub]     CrossRef
  • Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
    Paul Lee, Sheila Smith, Joyce Linderman, Amber B. Courville, Robert J. Brychta, William Dieckmann, Charlotte D. Werner, Kong Y. Chen, Francesco S. Celi
    Diabetes.2014; 63(11): 3686.     CrossRef
  • Food Function Study of Obesity and Fat Energy Metabolism
    Teruo Kawada
    Nippon Eiyo Shokuryo Gakkaishi.2014; 67(3): 119.     CrossRef
  • Kaempferia parviflora extract increases energy consumption through activation of BAT in mice
    Susumu Yoshino, Minji Kim, Riyo Awa, Hiroshige Kuwahara, Yuriko Kano, Teruo Kawada
    Food Science & Nutrition.2014; 2(6): 634.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2013; 32(6): 397.     CrossRef
  • Ghrelin
    Geetali Pradhan, Susan L. Samson, Yuxiang Sun
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 619.     CrossRef
  • Transient receptor potential activated brown fat thermogenesis as a target of food ingredients for obesity management
    Takeshi Yoneshiro, Masayuki Saito
    Current Opinion in Clinical Nutrition and Metabolic Care.2013; 16(6): 625.     CrossRef
  • Extensive hypermetabolic pattern of brown adipose tissue activation on 18F-FDG PET/CT in a patient diagnosed of catecholamine-secreting para-vesical paraganglioma
    J. Banzo, M.A. Ubieto, M.F. Berisa, A. Andrés, M.L. Mateo, L. Tardín, A. Parra, P. Razola, E. Prats
    Revista Española de Medicina Nuclear e Imagen Molecular.2013; 32(6): 397.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP