Diabetes & Metabolism Journal

Review

Pathophysiology
Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases: Songling Tang, Di Hao, Wen Ma, Lian Liu, Jiuyu Gao, Peng Yao, Haifang Yu, Lu Gan, Yu Cao; Diabetes Metab J. 2024;48(4):503-517. Published online February 15, 2024; DOI: https://doi.org/10.4093/dmj.2023.0213

5,732 View
299 Download
6 Web of Science
7 Crossref

Several mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca²⁺ flux, and mitochondrial dynamics disorders. Mitophagy, specialized autophagy, is responsible for clearing dysfunctional mitochondria in physiological and pathological conditions. As a paradox, inhibition and activation of mitophagy have been observed in obesity and diabetes-related heart disorders, with both exerting bidirectional effects. Suppressed mitophagy is beneficial to mitochondrial homeostasis, also known as benign mitophagy. On the contrary, in most cases, excessive mitophagy is harmful to dysfunctional mitochondria elimination and thus is defined as detrimental mitophagy. In obesity and diabetes, two classical pathways appear to regulate mitophagy, including PTEN-induced putative kinase 1 (PINK1)/Parkin-dependent mitophagy and receptors/adapters-dependent mitophagy. After the pharmacologic interventions of mitophagy, mitochondrial morphology and function have been restored, and cell viability has been further improved. Herein, we summarize the mitochondrial dysfunction and mitophagy alterations in obesity and diabetes, as well as the underlying upstream mechanisms, in order to provide novel therapeutic strategies for the obesity and diabetes-related heart disorders.

Citations

Citations to this article as recorded by

Influence of Mitochondrial NAD(P) + Transhydrogenase (NNT) on Hypothalamic Inflammation and Metabolic Dysfunction Induced by a High-Fat Diet in Mice
Giovanna Leite Santos, Ericka Francislaine Dias Costa, Ana Paula Dalla Costa, Ariane Maria Zanesco, Marcela Reymond Simoes, Fábio Rogério, Daniele Masselli Rodrigues Demolin, Claudia Daniele Carvalho Navarro, Lício Augusto Velloso, Annelise Francisco, Rog
Hormone and Metabolic Research.2025; 57(03): 199. CrossRef
Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Xiangyuan Meng, Hui Zhang, Zhenhu Zhao, Siyao li, Xin Zhang, Ruihan Guo, Huimin Liu, Yiling Yuan, Wanrui Li, Qi Song, Jinyu Liu
Molecular Medicine.2025;[Epub] CrossRef
WIPI1-mediated mitophagy dysfunction in ventricular remodeling associated with long-term diabetes mellitus
Daiqi Liu, Lu Zhou, Beizheng Xu, Gary Tse, Qingmiao Shao, Tong Liu
Cellular Signalling.2025; 130: 111663. CrossRef
Aconiti Lateralis Radix Praeparata ameliorates heart failure via PI3K/AKT/Bnip3 pathway
Wenxiu Liu, Xingju Zou, Yang Zheng, Yuan Zhang, Guijuan Cui, Siyu Liu, Chen Sun, Cheng Peng
Frontiers in Pharmacology.2025;[Epub] CrossRef
Mitophagy in the Pathogenesis of Obesity-Associated Cardiovascular Diseases: New Mechanistic and Therapeutic Insights
Kexin Huang, Jun Ren
Trends in Medical Research.2024; 19(1): 112. CrossRef
A review: Polysaccharides targeting mitochondria to improve obesity
Yongchao Chen, Rong Gao, Jun Fang, Sujuan Ding
International Journal of Biological Macromolecules.2024; 277: 134448. CrossRef
Iron chelators as mitophagy agents: Potential and limitations
Tereza Brogyanyi, Zdeněk Kejík, Kateřina Veselá, Petr Dytrych, David Hoskovec, Michal Masařik, Petr Babula, Robert Kaplánek, Tomáš Přibyl, Jaroslav Zelenka, Tomáš Ruml, Martin Vokurka, Pavel Martásek, Milan Jakubek
Biomedicine & Pharmacotherapy.2024; 179: 117407. CrossRef

First
Prev
Page of 1
Next
Last

Search