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7 "Kyu-Chang Won"
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Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon, The Committee of Clinical Practice Guidelines, Korean Diabetes Association and Committee of Clinical Practice Guidelines, Korean Society of Heart Failure
Diabetes Metab J. 2023;47(1):10-26.   Published online January 26, 2023
DOI: https://doi.org/10.4093/dmj.2022.0420
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart failure in patients with diabetes mellitus are important. This review discusses the current criteria for diagnosis and screening tools for heart failure and the currently recommended pharmacological therapies for heart failure. We also highlight the effects of anti-diabetic medications on heart failure.

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  • A Multicenter, Randomized, Open-Label Study to Compare the Effects of Gemigliptin Add-on or Escalation of Metformin Dose on Glycemic Control and Safety in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Treated with Metformin and SGLT-2 Inh
    Hae Jin Kim, Jung Hyun Noh, Min Kyong Moon, Sung Hee Choi, Seung-Hyun Ko, Eun-Jung Rhee, Kyu Yeon Hur, In-Kyung Jeong, Mark Yorek
    Journal of Diabetes Research.2024; 2024: 1.     CrossRef
  • Epicardial Adipose Tissue and Heart Failure, Friend or Foe?
    Dong-Hyuk Cho, Seong-Mi Park
    Diabetes & Metabolism Journal.2024; 48(3): 373.     CrossRef
  • Comparison of the effects of gemigliptin versus glimepiride on cardiac function in patients with type 2 diabetes uncontrolled with metformin: The gemi‐heart study
    Seung Min Chung, Jun Sung Moon, Jun Hwa Hong, In‐Chang Hwang, Soo Lim
    Diabetes, Obesity and Metabolism.2023; 25(8): 2181.     CrossRef
  • Optimization of guideline-directed medical treatment for heart failure patients with reduced ejection fraction
    Minjung Bak, Jin-Oh Choi
    The Korean Journal of Internal Medicine.2023; 38(5): 595.     CrossRef
Brief Report
Cardiovascular risk/Epidemiology
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Clinical Impact of Dysglycemia in Patients with an Acute Myocardial Infarction
Jae-Wook Chung, Yeong-Seon Park, Jeong-Eon Seo, Yeseul Son, Cheol-Woo Oh, Chan-Hee Lee, Jong-Ho Nam, Jung-Hee Lee, Jang-Won Son, Ung Kim, Jong-Seon Park, Kyu-Chang Won, Dong-Gu Shin
Diabetes Metab J. 2021;45(2):270-274.   Published online April 16, 2020
DOI: https://doi.org/10.4093/dmj.2019.0164
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Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   

This study aimed to determine the impact of dysglycemia on myocardial injury and cardiac dysfunction in acute myocardial infarctions (AMIs). From 2005 to 2016, a total of 1,593 patients with AMIs who underwent percutaneous coronary intervention were enrolled. The patients were classified into five groups according to the admission glucose level: ≤80, 81 to 140, 141 to 200, 201 to 260, and ≥261 mg/dL. The clinical and echocardiographic parameters and 30-day mortality were analyzed. The peak troponin I and white blood cell levels had a positive linear relationship to the admission glucose level. The left ventricular ejection fraction had an inverted U-shape trend, and the E/E' ratio was U-shaped based on euglycemia. The 30-day mortality also increased as the admission glucose increased, and the cut-off value for predicting the mortality was 202.5 mg/dL. Dysglycemia, especially hyperglycemia, appears to be associated with myocardial injury and could be another adjunctive parameter for predicting mortality in patients with AMIs.

Citations

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  • Optimal Low-Density Lipoprotein Cholesterol Levels in Adults Without Diabetes Mellitus: A Nationwide Population-Based Study Including More Than 4 Million Individuals From South Korea
    Ji Hye Huh, Sang Wook Park, Tae-Hwa Go, Dae Ryong Kang, Sang-Hak Lee, Jang-Young Kim
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association of admission hyperglycemia and all-cause mortality in acute myocardial infarction with percutaneous coronary intervention: A dose–response meta-analysis
    Shao-Yong Cheng, Hao Wang, Shi-Hua Lin, Jin-Hui Wen, Ling-Ling Ma, Xiao-Ce Dai
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Fenofibrate add-on to statin treatment is associated with low all-cause death and cardiovascular disease in the general population with high triglyceride levels
    Kyung-Soo Kim, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Metabolism.2022; 137: 155327.     CrossRef
  • Basic types of the first-day glycemia in acute myocardial infarction: Prognostic, diagnostic, threshold and target glycemia
    Goran Koracevic, Milan Djordjevic
    Primary Care Diabetes.2021; 15(3): 614.     CrossRef
  • Clinical Impact of Dysglycemia in Patients with an Acute Myocardial Infarction (Diabetes Metab J 2021;45:270-4)
    Bo-Yeon Kim
    Diabetes & Metabolism Journal.2021; 45(5): 787.     CrossRef
  • Clinical Impact of Dysglycemia in Patients with an Acute Myocardial Infarction (Diabetes Metab J 2021;45:270-4)
    Chan-Hee Lee
    Diabetes & Metabolism Journal.2021; 45(5): 791.     CrossRef
  • The Effects of Glucose Lowering Agents on the Secondary Prevention of Coronary Artery Disease in Patients with Type 2 Diabetes
    Inha Jung, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2021; 36(5): 977.     CrossRef
  • Effect of Admission Hyperglycemia on Short-Term Prognosis of Patients with Non-ST Elevation Acute Coronary Syndrome without Diabetes Mellitus
    Wei Liu, Zhijuan Li, Shiying Xing, Yanwei Xu, Gaetano Santulli
    Journal of Diabetes Research.2021; 2021: 1.     CrossRef
Original Article
Lifesytle
Changes in the Quality of Life in Patients with Type 2 Diabetes Mellitus According to Physician and Patient Behaviors
Young-Joo Kim, In-Kyung Jeong, Sin-Gon Kim, Dong Hyeok Cho, Chong-Hwa Kim, Chul-Sik Kim, Won-Young Lee, Kyu-Chang Won, Jin-Hye Cha, Juneyoung Lee, Doo-Man Kim
Diabetes Metab J. 2020;44(1):91-102.   Published online October 23, 2019
DOI: https://doi.org/10.4093/dmj.2018.0251
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  • 6 Web of Science
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Diabetes mellitus (DM) is the most common chronic metabolic disorder with an increasing prevalence worldwide. According to a previous study, physicians' treatment patterns or patients' behaviors change when they become aware of the risk for cardiovascular (CV) disease in patients with DM. However, there exist controversial reports from previous studies in the impact of physicians' behaviors on the patients' quality of life (QoL) improvements. So we investigate the changes in QoL according to physicians and patients' behavioral changes after the awareness of CV risks in patients with type 2 DM.

Methods

Data were obtained from a prospective, observational study where 799 patients aged ≥40 years with type 2 DM were recruited at 24 tertiary hospitals in Korea. Changes in physicians' behaviors were defined as changes in the dose/type of antihypertensive, lipid-lowering, and anti-platelet therapies within 6-month after the awareness of CV risks in patients. Changes in patients' behaviors were based on lifestyle modifications. Audit of Diabetes Dependent Quality of Life comprising 19-life-domains was used.

Results

The weighted impact score change for local or long-distance journey (P=0.0049), holidays (P=0.0364), and physical health (P=0.0451) domains significantly differed between the two groups; patients whose physician's behaviors changed showed greater improvement than those whose physician's behaviors did not change.

Conclusion

This study demonstrates that changes in physicians' behaviors, as a result of perceiving CV risks, improve QoL in some domains of life in DM patients. Physicians should recognize the importance of understanding CV risks and implement appropriate management.

Citations

Citations to this article as recorded by  
  • Prevalence, awareness, treatment and control of type 2 diabetes in southeast China: A population‐based study
    Xiangju Hu, Xin Fang, Minxia Wu
    Journal of Diabetes Investigation.2024;[Epub]     CrossRef
  • Spline Longitudinal Multi-response Model for the Detection of Lifestyle- Based Changes in Blood Glucose of Diabetic Patients
    Anna Islamiyati
    Current Diabetes Reviews.2022;[Epub]     CrossRef
  • Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes
    Han-sang Baek, Ji-Yeon Park, Jin Yu, Joonyub Lee, Yeoree Yang, Jeonghoon Ha, Seung Hwan Lee, Jae Hyoung Cho, Dong-Jun Lim, Hun-Sung Kim
    Endocrinology and Metabolism.2022; 37(4): 641.     CrossRef
  • Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells
    Shuyin Bao, Xiuzhi Wang, Sung Bo Cho, Yan-Ling Wu, Chengxi Wei, Shuying Han, Liming Bao, Qiong Wu, Wuliji Ao, Ji-Xing Nan
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Glycolipid metabolism and liver transcriptomic analysis of the therapeutic effects of pressed degreased walnut meal extracts on type 2 diabetes mellitus rats
    Yulan Li, Dan Chen, Chengmei Xu, Qingyujing Zhao, Yage Ma, Shenglan Zhao, Chaoyin Chen
    Food & Function.2020; 11(6): 5538.     CrossRef
  • Cause-of-death statistics in 2018 in the Republic of Korea
    Hyun-Young Shin, Jin Kim, Seokmin Lee, Min Sim Park, Sanghee Park, Sun Huh
    Journal of the Korean Medical Association.2020; 63(5): 286.     CrossRef
Corrigendum
Corrigendum: Hemorheologic Alterations in Patients with Type 2 Diabetes Mellitus Presented with an Acute Myocardial Infarction
Kyu-Hwan Park, Ung Kim, Kang-Un Choi, Jong-Ho Nam, Jung-Hee Lee, Chan-Hee Lee, Jang-Won Son, Jong-Seon Park, Dong-Gu Shin, Kyu-Chang Won, Jun Sung Moon, Yu Kyung Kim, Jang-Soo Suh
Diabetes Metab J. 2018;42(3):254-254.   Published online June 19, 2018
DOI: https://doi.org/10.4093/dmj.2018.0096
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  • Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis
    Chloé Turpin, Aurélie Catan, Olivier Meilhac, Emmanuel Bourdon, François Canonne-Hergaux, Philippe Rondeau
    International Journal of Molecular Sciences.2021; 22(11): 5843.     CrossRef
  • Self-care Efficacy and Health-related Quality of Life among Patients on Primary Treatment for Pulmonary Tuberculosis: The Mediating Effects of Self-Care Performance
    Hyun Ju Lee, Jiyoung Park
    Korean Journal of Adult Nursing.2020; 32(3): 305.     CrossRef
Original Articles
Others
Hemorheologic Alterations in Patients with Type 2 Diabetes Mellitus Presented with an Acute Myocardial Infarction
Kyu-Hwan Park, Ung Kim, Kang-Un Choi, Jong-Ho Nam, Jung-Hee Lee, Chan-Hee Lee, Jang-Won Son, Jong-Seon Park, Dong-Gu Shin, Kyu-Chang Won, Jun Sung Moon, Yu Kyung Kim, Jang-Soo Suh
Diabetes Metab J. 2018;42(2):155-163.   Published online March 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.42.2.155
  • 4,423 View
  • 44 Download
  • 14 Web of Science
  • 13 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus without AMI.

Methods

A total of 195 patients with T2DM were enrolled. Patients were divided into the study group with AMI (AMI+, n=77) and control group (AMI−, n=118) who had no history of coronary artery disease. Hemorheologic parameters such as EI and CSS were measured and compared between the two groups.

Results

The EI was lower (30.44%±1.77% in AMI+ and 31.47%±1.48% in AMI−, P<0.001) but the level of CSS was higher (316.13±108.20 mPa in AMI+ and 286.80±85.34 mPa in AMI−, P=0.040) in the AMI+. The CSS was significantly related to the erythrocyte sedimentation rate (R2=0.497, P<0.001) and use of dipeptidyl peptidase-4 inhibitors (R2=0.574, P=0.048).

Conclusion

Diabetics with AMI resulted in adverse hemorheologic changes with lower EI and higher CSS compared to diabetic subjects without AMI. Evaluation of the hemorheologic parameters may provide valuable supplementary information for managing patients with AMI and T2DM.

Citations

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  • Effects of dapagliflozin on cardiac function and short-term prognosis of patients with both acute myocardial infarction and type 2 diabetes mellitus
    Le ZHOU, Xiaohong GENG, Qian HU, Jiani GU, Yi CHEN
    Minerva Cardiology and Angiology.2024;[Epub]     CrossRef
  • Alpha-SNAP (M105I) mutation promotes neuronal differentiation of neural stem/progenitor cells through overactivation of AMPK
    Felipe A. Bustamante-Barrientos, Maxs Méndez-Ruette, Luis Molina, Tania Koning, Pamela Ehrenfeld, Carlos B. González, Ursula Wyneken, Roberto Henzi, Luis Federico Bátiz
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
  • Red Cell Distribution Width and Elongation Index in a Cohort of Patients With Juvenile Acute Myocardial Infarction
    Gregorio Caimi, Rosalia Lo Presti, Egle Corrado, Maria Montana, Melania Carlisi
    Clinical and Applied Thrombosis/Hemostasis.2023;[Epub]     CrossRef
  • Zinc improved erythrocyte deformability and aggregation in patients with beta-thalassemia: An in vitro study
    Mukaddes Sinan, Ozlem Yalcin, Zeynep Karakas, Evrim Goksel, Nesrin Zeynep Ertan
    Clinical Hemorheology and Microcirculation.2023; 85(1): 1.     CrossRef
  • Improved Erythrocyte Deformability Induced by Sodium-Glucose Cotransporter 2 Inhibitors in Type 2 Diabetic Patients
    Minkook Son, Ye Sung Lee, A Ram Hong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang, Sung Yang
    Cardiovascular Drugs and Therapy.2022; 36(1): 59.     CrossRef
  • Change of RBC Deformability During Hematopoietic Stem Cell Transplantation
    Yu Kyung Kim, Jae Min Lee
    Journal of Pediatric Hematology/Oncology.2022; 44(2): e329.     CrossRef
  • Hemoglobin concentration, hematocrit and red blood cell count predict major adverse cardiovascular events in patients with familial hypercholesterolemia
    Martine Paquette, Sophie Bernard, Alexis Baass
    Atherosclerosis.2021; 335: 41.     CrossRef
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    Yu Kyung Kim, Young Tae Lim, Jang Soo Suh, Jeong Ok Hah, Jae Min Lee
    Clinical Hemorheology and Microcirculation.2020; 75(3): 361.     CrossRef
  • Fasting Plasma Glucose Variability and Gastric Cancer Risk in Individuals Without Diabetes Mellitus: A Nationwide Population-Based Cohort Study
    So-hyeon Hong, Eunjin Noh, Jinsil Kim, Soon Young Hwang, Jun A. Kim, You-Bin Lee, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
    Clinical and Translational Gastroenterology.2020; 11(9): e00221.     CrossRef
  • Use of RBC deformability index as an early marker of diabetic nephropathy
    Sang Bae Lee, Yu-Sik Kim, Jung Hye Kim, Kahui Park, Ji Sun Nam, Shinae Kang, Jong Suk Park, Sehyun Shin, Chul Woo Ahn
    Clinical Hemorheology and Microcirculation.2019; 72(1): 75.     CrossRef
  • Haemorheological and haemostatic alterations in coeliac disease and inflammatory bowel disease in comparison with non-coeliac, non-IBD subjects (HERMES): a case–control study protocol
    Zsolt Szakács, Beáta Csiszár, Péter Kenyeres, Patrícia Sarlós, Bálint Erőss, Alizadeh Hussain, Ágnes Nagy, Balázs Kőszegi, Ibolya Veczák, Nelli Farkas, Emőke Bódis, Katalin Márta, Andrea Szentesi, Margit Tőkés-Füzesi, Tímea Berki, Áron Vincze, Kálmán Tóth
    BMJ Open.2019; 9(3): e026315.     CrossRef
  • Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes
    Hoyoon Lee, Wonwhi Na, Sang Bae Lee, Chul Woo Ahn, Jun Sung Moon, Kyu Chang Won, Sehyun Shin
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • PREVALENCE AND FORECASTING OF ALIMENTARY RISK FACTORS AMONG PATIENTS WITH MYOCARDIAL INFARCTION
    A. V. Ivanenko, R. S. Goloschapov-Aksenov, Dmitry I. Kicha
    Hygiene and sanitation.2019; 98(8): 873.     CrossRef
Hexane Extract of Orthosiphon stamineus Induces Insulin Expression and Prevents Glucotoxicity in INS-1 Cells
Hae-Jung Lee, Yoon-Jung Choi, So-Young Park, Jong-Yeon Kim, Kyu-Chang Won, Jong-Keun Son, Yong-Woon Kim
Diabetes Metab J. 2015;39(1):51-58.   Published online February 16, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.1.51
  • 4,608 View
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AbstractAbstract PDFPubReader   
Background

Hyperglycemia, a characteristic feature of diabetes, induces glucotoxicity in pancreatic β-cells, resulting in further impairment of insulin secretion and worsening glycemic control. Thus, preservation of insulin secretory capacity is essential for the management of type 2 diabetes. In this study, we evaluated the ability of an Orthosiphon stamineus (OS) extract to prevent glucotoxicity in insulin-producing cells.

Methods

We measured insulin mRNA expression and glucose-stimulated insulin secretion (GSIS) in OS-treated INS-1 cells after exposure to a high glucose (HG; 30 mM) concentration.

Results

The hexane extract of OS elevated mRNA expression of insulin as well as pancreatic and duodenal homeobox-1 of INS-1 cells in a dose-dependent manner. The hexane OS extract also increased the levels of phosphorylated phosphatidylinositol 3-kinase (PI3K) in a concentration-dependent manner. Additionally, Akt phosphorylation was elevated by treatment with 100 and 200 µmol of the hexane OS extract. Three days of HG exposure suppressed insulin mRNA expression and GSIS; these expressions were restored by treatment with the hexane OS extract. HG elevated peroxide levels in the INS-1 cells. These levels were unaffected by OS treatment under both normal and hyperglycemic conditions.

Conclusion

Our results suggested that the hexane extract of OS elevates insulin mRNA expression and prevents glucotoxicity induced by a 3-day treatment with HG. This was associated with the activation of PI-3K and Akt.

Citations

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  • An Updated Review of Ethnobotany, Ethnopharmacology, Phytochemistry and Pharmacological Activities of Orthosiphon stamineus Benth
    Anandarajagopal Kalusalingam, Dania Najiha Hasnu, Abdullah Khan, Ching Siang Tan, Bama Menon, Venkateshan Narayanan, Khang Wen Goh, Asmuni Mohd Ikmal, Noraini Talip, Poonguzhali Subramanian, Long Chiau Ming
    Malaysian Applied Biology.2024; 53(1): 1.     CrossRef
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    Jae Eun Park, Ji Sook Han
    Toxicology in Vitro.2023; 93: 105665.     CrossRef
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    Qirou Wang, Jia Wang, Nannan Li, Junyu Liu, Jingna Zhou, Pengwei Zhuang, Haixia Chen
    Molecules.2022; 27(2): 444.     CrossRef
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    Yun Luo, Yue Liu, Quan Wen, Yulin Feng, Ting Tan
    Journal of Separation Science.2021; 44(9): 1805.     CrossRef
  • Short-Term Protocols to Obtain Insulin-Producing Cells from Rat Adipose Tissue: Signaling Pathways and In Vivo Effect
    Krista Minéia Wartchow, Letícia Rodrigues, Lucas Zingano Suardi, Barbara Carolina Federhen, Nicholas Guerini Selistre, Carlos-Alberto Gonçalves, Patrícia Sesterheim
    International Journal of Molecular Sciences.2019; 20(10): 2458.     CrossRef
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    Plant Methods.2019;[Epub]     CrossRef
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    Dhamraa Waleed Al-dualimi, Aman Shah Abdul Majid, Sarah Furqan Faisal Al-Shimary, Amal Aziz Al-Saadi, Raghdaa Al Zarzour, Muhammad Asif, Chern Ein Oon, Amin Malik Shah Abdul Majid
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