Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the development of various tissues. However, its role in pancreas development has not yet been elucidated.
Pancreatic progenitor cell-specific
PRMT1 critically contributes to pancreas development by destabilizing the NGN3 protein.
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