Diabetes & Metabolism Journal

Review

Current Antiplatelet Treatment Strategy in Patients with Diabetes Mellitus: Jung Hwa Jung, Udaya S. Tantry, Paul A. Gurbel, Young-Hoon Jeong; Diabetes Metab J. 2015;39(2):95-113. Published online April 20, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.2.95

6,792 View
98 Download
31 Web of Science
25 Crossref

Patients with diabetes mellitus (DM) have accelerated atherosclerosis with an increased risk for atherothrombotic cardiovascular complications. A state of high platelet reactivity and activation, hypercoagulability (prothrombotic state) and a subdued response to standard antiplatelet agents may explain high rate of adverse cardiovascular events in patients with DM. Several antithrombotic treatment strategies have been developed to control the prothrombotic state in patients with DM: dose modification of commonly used agents; use of potent agents; and addition of a third antithrombotic drug (triple therapy) to commonly prescribed dual antiplatelet therapy of aspirin and a P2Y₁₂ inhibitor. The present review aims to provide an overview of the current knowledge on platelet abnormalities in patients with DM, focusing on the challenges and perspectives of antiplatelet treatment strategies in this population.

Citations

Citations to this article as recorded by

Mice expressing nonpolymerizable fibrinogen have reduced arterial and venous thrombosis with preserved hemostasis
Woosuk S. Hur, Tomohiro Kawano, Jean Marie N. Mwiza, David S. Paul, Robert H. Lee, Emily G. Clark, Emma G. Bouck, Ananya Dutta, Can Cai, Stephen R. Baker, Martin Guthold, Nigel Mackman, Pierre Mangin, Alisa S. Wolberg, Wolfgang Bergmeier, Matthew J. Flick
Blood.2024; 143(2): 105. CrossRef
New Score Models for Predicting Bleeding and Ischemic of Ticagrelor Therapy in Patients with Diabetes Mellitus
Xiaotong Xia, Shu Chen, Chang Cao, YanRong Ye, Yun Shen
Clinical and Applied Thrombosis/Hemostasis.2024;[Epub] CrossRef
On‐Treatment Platelet Reactivity and Ischemic Outcomes in Patients With Diabetes Mellitus: Two‐Year Results From ADAPT‐DES
Bahira Shahim, Björn Redfors, Thomas D. Stuckey, Mengdan Liu, Zhipeng Zhou, Bernhard Witzenbichler, Giora Weisz, Michael J. Rinaldi, Franz‐Josef Neumann, D. Christopher Metzger, Timothy D. Henry, David A. Cox, Peter L. Duffy, Bruce R. Brodie, Iva Srdanovi
Journal of the American Heart Association.2023;[Epub] CrossRef
Platelet Glycoprotein-Ib (GPIb) May Serve as a Bridge between Type 2 Diabetes Mellitus (T2DM) and Atherosclerosis, Making It a Potential Target for Antiplatelet Agents in T2DM Patients
Muttia Amalia, Meidi Utami Puteri, Fadlina Chany Saputri, Rani Sauriasari, Bambang Widyantoro
Life.2023; 13(7): 1473. CrossRef
Polymorphisms of Genes Related to Phase II Metabolism and Resistance to Clopidogrel
Abdullah Alkattan, Ahmed Alkhalifah, Eman Alsalameen, Fatimah Alghanim, Nashwa Radwan
Pharmacogenomics.2022; 23(1): 61. CrossRef
Prolonged dual antiplatelet therapy after drug-eluting stent implantation in patients with diabetes mellitus: A nationwide retrospective cohort study
Seung-Jun Lee, Dong-Woo Choi, Choongki Kim, Yongsung Suh, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Eun-Cheol Park, Yangsoo Jang, Chung-Mo Nam, Myeong-Ki Hong
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
New opportunities of antithrombotic therapy in patients with type 2 diabetes mellitus and stable coronary heart disease for reducing the cardiovascular risk and cardiovascular complications: THEMIS, THEMIS-PCI trials
Victor I. Kalashnikov, Marina S. Michurova
Terapevticheskii arkhiv.2022; 94(10): 1204. CrossRef
Ischemic and Bleeding Events of Ticagrelor Monotherapy in Korean Patients With and Without Diabetes Mellitus: Insights From the TICO Trial
Kyeong Ho Yun, Jae Young Cho, Seung Yul Lee, Sang Jae Rhee, Byeong Keuk Kim, Myeong Ki Hong, Yangsoo Jang, Seok Kyu Oh
Frontiers in Pharmacology.2021;[Epub] CrossRef
Long-term outcomes of ischaemic stroke patients with diabetes in a multi-ethnic cohort in Singapore
Ei Zune The, Mei Yen Ng, Geelyn JL Ng, Bernadette GC Er, Amy ML Quek, Prakash Paliwal, Leonard L Yeo, Bernard PL Chan, Vijay K Sharma, Hock Luen Teoh, Eric YH Khoo, Raymond CS Seet
Annals of the Academy of Medicine, Singapore.2021; 50(1): 16. CrossRef
Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury
Kornela Hałucha, Alina Rak-Pasikowska, Iwona Bil-Lula, David J. Chambers
Cardiology Research and Practice.2021; 2021: 1. CrossRef
Pre- and Post-Conditioning of the Heart: An Overview of Cardioprotective Signaling Pathways
Denise Coutinho de Miranda, Gabriela de Oliveira Faria, Milla Marques Hermidorff, Fernanda Cacilda dos Santos Silva, Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
Current Vascular Pharmacology.2021; 19(5): 499. CrossRef
Post-Transcriptional Expression Control in Platelet Biogenesis and Function
Carolin T. Neu, Tony Gutschner, Monika Haemmerle
International Journal of Molecular Sciences.2020; 21(20): 7614. CrossRef
The impact of metformin and aspirin on T-cell mediated inflammation: A systematic review of in vitro and in vivo findings
Tawanda Maurice Nyambuya, Phiwayinkosi Vusi Dludla, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Siphamandla Raphael Ngcobo, Luca Tiano, Bongani Brian Nkambule
Life Sciences.2020; 255: 117854. CrossRef
Short- versus long-term dual antiplatelet therapy after second-generation drug-eluting stent implantation in patients with diabetes mellitus: A meta-analysis of randomized controlled trials
Hongyu Zhang, Junsong Ke, Jun Huang, Kai Xu, Yun Chen, Timir Paul
PLOS ONE.2020; 15(12): e0242845. CrossRef
Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model
Ming Zhou, Meng Gao, Yanwei Luo, Rong Gui, Hongwen Ji
Platelets.2019; 30(4): 452. CrossRef
Circulating blood cells and extracellular vesicles in acute cardioprotection
Sean M Davidson, Ioanna Andreadou, Lucio Barile, Yochai Birnbaum, Hector A Cabrera-Fuentes, Michael V Cohen, James M Downey, Henrique Girao, Pasquale Pagliaro, Claudia Penna, John Pernow, Klaus T Preissner, Péter Ferdinandy
Cardiovascular Research.2019; 115(7): 1156. CrossRef
Comparison of 1-year clinical outcomes between prasugrel and ticagrelor versus clopidogrel in type 2 diabetes patients with acute myocardial infarction underwent successful percutaneous coronary intervention
Kye Taek Ahn, Seok-Woo Seong, Ung Lim Choi, Seon-Ah Jin, Jun Hyung Kim, Jae-Hwan Lee, Si Wan Choi, Myung Ho Jeong, Shung Chull Chae, Young Jo Kim, Chong Jin Kim, Hyo-Soo Kim, Myeong-Chan Cho, Hyeon-Cheol Gwon, Jin-Ok Jeong, In-Whan Seong
Medicine.2019; 98(11): e14833. CrossRef
Fibrin Clot Strength in Patients with Diabetes Mellitus Measured by Thrombelastography
Benjamin T. Maatman, Glen Schmeisser, Rolf P. Kreutz
Journal of Diabetes Research.2018; 2018: 1. CrossRef
Role of proprotein convertase subtilisin/kexin type 9 inhibitors in patients with coronary artery disease undergoing percutaneous coronary intervention
Eliano P. Navarese, Michalina Kołodziejczak, Aniela Petrescu, Bernhard Wernly, Michael Lichtenauer, Alexander Lauten, Antonino Buffon, Wojciech Wanha, Vincenzo Pestrichella, Gennaro Sardella, Gaetano Contegiacomo, Udaya Tantry, Kevin Bliden, Jacek Kubica,
Expert Review of Cardiovascular Therapy.2018; 16(6): 419. CrossRef
Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts
Isabella Russo, Saveria Femminò, Cristina Barale, Francesca Tullio, Stefano Geuna, Franco Cavalot, Pasquale Pagliaro, Claudia Penna
Frontiers in Physiology.2018;[Epub] CrossRef
Aortic thrombosis in dogs
Trevor P.E. Williams, Scott Shaw, Adam Porter, Larry Berkwitt
Journal of Veterinary Emergency and Critical Care.2017; 27(1): 9. CrossRef
Challenges in Patients with Diabetes: Improving Clinical Outcomes After Percutaneous Coronary Intervention Through EVOlving Stent Technology
Robert A Byrne, Shmuel Banai, Roisin Colleran, Antonio Colombo
Interventional Cardiology Review.2017; 13(01): 40. CrossRef
Adding CABG to the Dual Antiplatelet Salad
Glenn N. Levine, Faisal G. Bakaeen
Journal of the American College of Cardiology.2017; 69(2): 128. CrossRef
The association between arterial stiffness and tongue manifestations of blood stasis in patients with type 2 diabetes
Po-Chi Hsu, Yu-Chuen Huang, John Y. Chiang, Hen-Hong Chang, Pei-Yung Liao, Lun-Chien Lo
BMC Complementary and Alternative Medicine.2016;[Epub] CrossRef
Platelet phenotype changes associated with breast cancer and its treatment
Chris E. Holmes, Jamie E. Levis, David J. Schneider, Nadia M. Bambace, Deva Sharma, Inder Lal, Marie E. Wood, Hyman B. Muss
Platelets.2016; 27(7): 703. CrossRef

Original Article

Clinical Significance of the Presence of Autonomic and Vestibular Dysfunction in Diabetic Patients with Peripheral Neuropathy: Soo Kyoung Kim, Kyeong Ju Lee, Jong Ryeal Hahm, Sang Min Lee, Tae Sik Jung, Jung Hwa Jung, Sungsu Kim, Deok Ryong Kim, Seong-Ki Ahn, Won-Hee Choi, Soon Il Chung; Diabetes Metab J. 2012;36(1):64-69. Published online February 17, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.1.64

4,272 View
47 Download
19 Crossref

Abstract PDF PubReader

Background

We investigated the prevalence of diabetic autonomic neuropathy (DAN) and vestibular dysfunction (VD) in diabetic patients with peripheral neuropathy.

Methods

Thirty-five diabetic patients with peripheral neuropathy were enrolled from August 2008 to July 2009. All subjects underwent autonomic function tests. Nineteen of the patients (54.3%) underwent videonystagmography.

Results

Diabetic autonomic neuropathy was observed in 28 patients (80%). A mild degree of autonomic failure was observed in 18 patients (64.3%), and a moderate degree of autonomic failure was observed in ten patients (35.7%). Factors related to DAN included diabetic nephropathy (P=0.032), degree of chronic kidney disease (P=0.003), and duration of diabetes (P=0.044). Vestibular dysfunction was observed in 11 of 19 patients (57.9%). There was no significant association between DAN and VD.

Conclusion

Diabetic autonomic neuropathy was observed in 28 diabetic patients (80%) with peripheral neuropathy. Vestibular dysfunction was observed in nearly 60% of diabetic patients with peripheral neuropathy who complained of dizziness but showed no significant association with DAN. Diabetic patients who complained of dizziness need to examine both autonomic function and vestibular function.

Citations

Citations to this article as recorded by

Physiotherapists’ Perspectives on Type 2 Diabetes Management and as a Primary Condition for Referral to Physiotherapy Services: A Qualitative Descriptive Study
Sarah M. Janssen, Denise M. Connelly, Heather Gillis
Physiotherapy Canada.2024; 76(3): 282. CrossRef
β-Glucans obtained from fungus for wound healing: A review
Chunhua Xu, Fengxia Wang, Shibing Guan, Lizhen Wang
Carbohydrate Polymers.2024; 327: 121662. CrossRef
Dynamic and static balance functions in hemodialysis patients and non‐dialysis dependent CKD patients
Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita, Ichiei Narita
Therapeutic Apheresis and Dialysis.2023; 27(3): 412. CrossRef
Micro (mi) RNA and Diabetic Retinopathy
Sadashiv, Praveen Sharma, Shailendra Dwivedi, Sunita Tiwari, Pankaj Kumar Singh, Amit Pal, Sandeep Kumar
Indian Journal of Clinical Biochemistry.2022; 37(3): 267. CrossRef
Subclinical vestibular dysfunction in type 1 diabetes mellitus
Abdollah Moossavi, Moslem Shaabani, Ensieh Nasli Esfahani, Mohsen Vahedi, Zakaria Enayati
Hearing, Balance and Communication.2021; 19(2): 86. CrossRef
Effect of Yogasanas Versus Gaze Stability and Habituation Exercises on Dizziness in Vestibular Dysfunction
Preeti S Gazbare, Namrata D Rawtani, Manisha Rathi, Tushar J Palekar
Neurology India.2021; 69(5): 1241. CrossRef
Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing

Que Bai, Kai Han, Kai Dong, Caiyun Zheng, Yanni Zhang, Qianfa Long, Tingli Lu
International Journal of Nanomedicine.2020; Volume 15: 9717. CrossRef
Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management
Veena Vijayakumar, Sushanta K. Samal, Smita Mohanty, Sanjay K. Nayak
International Journal of Biological Macromolecules.2019; 122: 137. CrossRef
Auditory function and motor proficiency in type 1 diabetic children: A case-control study
Jalali Mir Mohammad, Soleimani Robabeh, Koohmanai Shahin, Tizno Saeed, Akbari Maryam
International Journal of Pediatric Otorhinolaryngology.2018; 109: 7. CrossRef
Vestibular profile of type 1 versus type 2 chronic diabetes mellitus
Ola Abdallah Ibraheem, Mohammad Ramadan Hassaan, Mayada Mohamed Mousa
Hearing, Balance and Communication.2017; 15(3): 133. CrossRef
Glycemic variability is an important risk factor for cardiovascular autonomic neuropathy in newly diagnosed type 2 diabetic patients
Wen Xu, Yanhua Zhu, Xubin Yang, Hongrong Deng, Jinhua Yan, Shaoda Lin, Huazhang Yang, Hong Chen, Jianping Weng
International Journal of Cardiology.2016; 215: 263. CrossRef
Impact of Diabetic Complications on Balance and Falls: Contribution of the Vestibular System
Linda J. D'Silva, James Lin, Hinrich Staecker, Susan L. Whitney, Patricia M. Kluding
Physical Therapy.2016; 96(3): 400. CrossRef
Shedding light on miR-26a: Another key regulator of angiogenesis in diabetic wound healing
Carlos Zgheib, Kenneth W. Liechty
Journal of Molecular and Cellular Cardiology.2016; 92: 203. CrossRef
Augmented asymmetrical visual field dependence in asymptomatic diabetics: Evidence of subclinical asymmetrical bilateral vestibular dysfunction
Rima Abdul Razzak, Jeffery Bagust, Sharon Docherty, Wiam Hussein, Abdullah Al-Otaibi
Journal of Diabetes and its Complications.2015; 29(1): 68. CrossRef
Associations between autonomic dysfunction and pain in chemotherapy‐induced polyneuropathy
H. Nahman‐Averbuch, Y. Granovsky, E. Sprecher, M. Steiner, T. Tzuk‐Shina, D. Pud, D. Yarnitsky
European Journal of Pain.2014; 18(1): 47. CrossRef
Balance training in the intervention of fall risk in elderly with diabetic peripheral neuropathy: A review
Xi Pan, Jiao-jiao Bai
International Journal of Nursing Sciences.2014; 1(4): 441. CrossRef
Synkope aus der Sicht des Neurologen
A. Bickel, J. Röther
Herz.2014; 39(4): 443. CrossRef
The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing
João Moura, Elisabet Børsheim, Eugenia Carvalho
Genes.2014; 5(4): 926. CrossRef
Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review
Liane I.F. Moura, Ana M.A. Dias, Eugénia Carvalho, Hermínio C. de Sousa
Acta Biomaterialia.2013; 9(7): 7093. CrossRef

Letter

The Classification of Diabetic Patients Presenting Diabetic Ketoacidosis: The Characteristics of Fulminant Type 1 Diabetes.: Tae Sik Jung, Jong Ryeal Hahm, Jung Hwa Jung, Soon Il Chung; Korean Diabetes J. 2008;32(6):534-536. Published online December 1, 2008; DOI: https://doi.org/10.4093/kdj.2008.32.6.534

2,057 View
23 Download
1 Crossref

Abstract PDF

No abstract available.

Citations

Citations to this article as recorded by

A Case of Fulminant Type 1 Diabetes Mellitus in an Elderly Patient
Seung Min Woo, Seung Hyun Hong, Sung Yun Lee, Su Heui Lee, Duc Ky Lee, Sae Jeong Yang
The Journal of Korean Diabetes.2015; 16(3): 225. CrossRef

Original Articles

Effects of Islet Transplantation on Endogenous beta-cell Regeneration after Partial Pancreatectomy in Rodents.: Hye Seung Jung, You Ran Ahn, Seung Hoon Oh, Jung Hwa Jung, Tae Hyun Kim, You Cheol Hwang, Mira Kang, Yongsuk Bae, Young seok Kim, Jae Hoon Chung, Yong Ki Min, Myung Shik Lee, Moon Kyu Lee, Kwang Won Kim; Korean Diabetes J. 2007;31(2):113-122. Published online March 1, 2007; DOI: https://doi.org/10.4093/jkda.2007.31.2.113

2,359 View
20 Download

Abstract PDF: BACKGROUND
Islet transplantation is one of regimens supplying the deficient insulin in diabetes patients, but the effects of islet grafts on the changes of endogenous beta-cells are not clear. In the present study, we examined the changes of endogenous beta-cell mass after islet transplantation in partially pancreatectomized mice. METHODS: Balb/c mice were 70% pancreatectomized, transplanted with syngeneic islets (group IV), and were compared with pancreatectomized mice treated with insulin (group III) or no insulin (group II). Blood glucose levels and body weight were monitored. Remnant pancreas was obtained at 6 or 10 days after pancreatectomy, and immunohistochemical staining was done for the evaluation of beta-cell mass changes. RESULTS: Hyperglycemia and weight loss were induced after pancreatectomy. After islet transplantation or insulin treatment, blood glucose levels recovered to normal, and body weight started to increase. Plasma insulin levels were higher and beta-cell mass was larger in group IV than in group II (P < 0.05). Especially, the difference of beta-cell mass between them was more evident at 7 days as compared to at 3 day after transplantation. When compared to group III, group IV showed larger individual beta-cell area after 7 days and larger beta-cell mass after 3 days of islet transplantation (P < 0.05). CONCLUSION: These observations indicate that islet transplantation plays a role in enhancing remnant beta-cell regeneration after partial pancreatectomy in rodents.

A Case of Newly Diagnosed Type 2 Diabetes Mellitus Presenting with Rhinocerebral Mucormycosis.: Jung Hwa Jung, Jong Ryeal Hahm, Mi Yeon Kang, Sung Won Moon, Tae Sik Jung, Deok Ryong Kim, Soon Il Chung; Korean Diabetes J. 2004;28(3):225-230. Published online June 1, 2004

1,091 View
18 Download

Abstract PDF: Rhinocerebral mucormycosis(RM) is a rare opportunistic fungal infection that mainly occurs in immunocompromised or diabetic patients, but rarely in healthy indi-viduals. This fungal infection usually begins at the nose and progresses through the paranasal sinuses, and secondarily invading the orbit and central nervous system. Because of its rapid progression and high mortality, early diagnosis and treatment are crucial to increase the patient survival rate. A combination of ampho-tericin B administration and surgery is a standard repertoire of RM treatment. Herein, a case in which a 69-year-old male patient with type 2 diabetes mellitus, presentings as RM, is reported. This patient had never been diagnosed with diabetes mellitus until the diabetes and RM were identified by us using the oral glucose tolerance test, measurement of the glycated hemoglobin level and a paranasal sinus CT scan. The RM was further confirmed by a biopsy of an oral mucosal ulcerative lesion. This case suggests that RM can present in newly diagnosed type 2 diabetes patients.

First
Prev
Page of 1
Next
Last

Search