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  Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
• Proton Pump Inhibitor Co-Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulants and a Prior History of Upper Gastrointestinal Tract Bleeding
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  Cardiovascular Drugs and Therapy.2022; 36(4): 679.     CrossRef
• Institutional case volume-incorporated mortality risk prediction model for cardiac surgery
  Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongnyeok Park, Ho Geol Ryu
  Asian Journal of Surgery.2022; 45(1): 189.     CrossRef
• Does Surgical Ablation of Atrial Fibrillation Benefit Patients Undergoing Bioprosthetic Valve Replacement?
  Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
  Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906.     CrossRef
• Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
  Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyunsun Lim, Jisoo Lee
  The Korean Journal of Internal Medicine.2022; 37(6): 1250.     CrossRef
• Validation of Dynamic Aspartate‐to–Alanine Aminotransferase Ratio for Predicting Liver Disease Mortality
  In‐Ae Song, Eun Sun Jang, Tak Kyu Oh
  Hepatology Communications.2022; 6(4): 740.     CrossRef
• Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
  Chan Joo Lee, Ji-Yeon Lee, Kyungdo Han, Da Hye Kim, Hanna Cho, Kwang Joon Kim, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee, Sungha Park
  Hypertension.2022; 79(1): 218.     CrossRef
• Continuing regular physical activity and maintaining body weight have a synergistic interaction in improving survival: a population-based cohort study including 6.5 million people
  Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak
  European Journal of Preventive Cardiology.2022; 29(3): 547.     CrossRef
• Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study
  Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
  Neurological Sciences.2022; 43(5): 3395.     CrossRef
• Underutilisation of prophylactic G-CSF in breast cancer patients receiving adjuvant docetaxel/cyclophosphamide chemotherapy
  Minhee Ku, Nam Kyung Je
  Journal of Chemotherapy.2022; 34(8): 534.     CrossRef
• Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
  Bum Sik Tae, Young Eun Yoon, Woong Na, Kyung Jin Oh, Sung Yul Park, Jae Young Park, Hong Sang Moon
  Investigative and Clinical Urology.2022; 63(1): 92.     CrossRef
• Acromegaly and cardiovascular outcomes: a cohort study
  Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
  European Heart Journal.2022; 43(15): 1491.     CrossRef
• Pericardial Versus Porcine Valves for Surgical Aortic Valve Replacement
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  Korean Circulation Journal.2022; 52(2): 136.     CrossRef
• Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
  Changil Choi, Jong Keun Kim, Kyungdo Han, Young Goo Lee, Jun Hyun Han
  Investigative and Clinical Urology.2022; 63(1): 63.     CrossRef
• Comprehensive risk assessment for hospital-acquired pneumonia: sociodemographic, clinical, and hospital environmental factors associated with the incidence of hospital-acquired pneumonia
  Bo-Guen Kim, Minwoong Kang, Jihyun Lim, Jin Lee, Danbee Kang, Minjung Kim, Jinhee Kim, Hyejeong Park, Kyung Hoon Min, Juhee Cho, Kyeongman Jeon
  BMC Pulmonary Medicine.2022;[Epub]     CrossRef
• Metabolic Disease Incidence After Allogeneic Stem Cell Transplantation: A Nationwide Korean Case-Control Study
  Jeonghoon Ha, See Hyun Park, Sung-Soo Park, Seunghoon Han
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• Development of eClaim system for private indemnity health insurance in South Korea: Compatibility and interoperability
  Sungchul Bae, Byoung-Kee Yi
  Health Informatics Journal.2022;[Epub]     CrossRef
• Incidence of Depression after Traumatic Brain Injury: A Nationwide Longitudinal Study of 2.2 Million Adults
  Yoonjeong Choi, Eun Young Kim, Jiyu Sun, Han-Kyoul Kim, Ye Seol Lee, Byung-Mo Oh, Hye Yoon Park, Ja-Ho Leigh
  Journal of Neurotrauma.2022; 39(5-6): 390.     CrossRef
• Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
  Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
  Biomedicines.2022; 10(2): 303.     CrossRef
• Clinical outcomes of early closure versus conservative strategy after diagnosis with atrial septal defect: a nationwide population-based cohort study
  Sun-Yang Min, Ji Sung Lee, Duk-Woo Park, Jong-Min Song
  European Journal of Cardio-Thoracic Surgery.2022;[Epub]     CrossRef
• Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
  Gyeongsil Lee, Seulggie Choi, Yoosun Cho, Sang Min Park
  Clinical Nutrition Research.2022; 11(1): 32.     CrossRef
• Long-term prognosis and causes of death among survivors after out-of-hospital cardiac arrest: A population-based longitudinal study
  Yongil Cho, Jaehoon Oh, Jeong-Hun Shin, Byung Sik Kim, Jin-Kyu Park, Jun Ho Lee, Jae Hwan Kim, Minae Park
  Resuscitation.2022; 173: 31.     CrossRef
• Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study
  Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim, Kyungdo Han, Jin-hyung Jung, Do Hoon Kim, Joo-Hyun Park
  Scientific Reports.2022;[Epub]     CrossRef
• Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
  Ji-Yeon Lee, Young-eun Kim, Kyungdo Han, Eugene Han, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
  JAMA Network Open.2022; 5(2): e220262.     CrossRef
• Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
  Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
  Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
• Non-Alcoholic Fatty Liver Disease Defined by Fatty Liver Index and Incidence of Heart Failure in the Korean Population: A Nationwide Cohort Study
  Byoungduck Han, Gyu Bae Lee, Sun Young Yim, Kyung-Hwan Cho, Koh Eun Shin, Jung-Hwan Kim, Yong-Gyu Park, Kyung-Do Han, Yang-Hyun Kim
  Diagnostics.2022; 12(3): 663.     CrossRef
• Contact with the health care system prior to suicide: A nationwide population-based analysis using linkage national death certificates and national health insurance data
  Eun Jee Park, Nam Ju Ji, Weon Young Lee
  Journal of Psychiatric Research.2022; 149: 226.     CrossRef
• Association between asthma or chronic obstructive pulmonary disease and chronic otitis media
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  Scientific Reports.2022;[Epub]     CrossRef
• Prognosis of pregnancy after breast cancer diagnosis according to the type of treatment: A population-based study in Korea by the SMARTSHIP group
  Soo Youn Bae, Jihyoun Lee, Ji Sung Lee, Jae Sun Yoon, Ku Sang Kim, Yoo Seok Kim, Zisun Kim, Jun Won Min, Eun-Jung Shim, Ilkyun Lee, Min Hyuk Lee, Sungmin Park
  The Breast.2022; 63: 46.     CrossRef
• Fracture risk and impact of osteoporosis in patients with Parkinson’s disease: a nationwide database study
  Tae-lim Kim, Seong Jun Byun, Min Yong Seong, Byung-Mo Oh, Sang Jun Park, Han Gil Seo
  Journal of Bone and Mineral Metabolism.2022; 40(4): 602.     CrossRef
• Risk prediction models incorporating institutional case volume for mortality after hip fracture surgery in the elderly
  Seokha Yoo, Eun Jin Jang, Junwoo Jo, Hannah Lee, Yoonbin Hwang, Ho Geol Ryu
  Archives of Orthopaedic and Trauma Surgery.2022; 143(5): 2307.     CrossRef
• Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study
  Seung Hoon Kim, Yong-Moon Park, Kyungdo Han, Seung Hyun Ko, Shin Young Kim, So Hyang Song, Chi Hong Kim, Kyu Yeon Hur, Sung Kyoung Kim, Juan F. Orueta
  PLOS ONE.2022; 17(4): e0266262.     CrossRef
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  Young Bae Choi, Keon Hee Yoo
  Cancer Research and Treatment.2022; 54(2): 572.     CrossRef
• The Effect of Alcohol Drinking on Metabolic Syndrome and Obesity in Koreans: Big Data Analysis
  Eun Jung Park, Hye Jung Shin, Sung Soo Kim, Ki Eun Kim, Sun Hyun Kim, Youl Ri Kim, Kyong Mee Chung, Kyung Do Han
  International Journal of Environmental Research and Public Health.2022; 19(9): 4949.     CrossRef
• Prolonged or Transition to Metabolically Unhealthy Status, Regardless of Obesity Status, Is Associated with Higher Risk of Cardiovascular Disease Incidence and Mortality in Koreans
  Juhee Lee, So-Young Kwak, Dahyun Park, Ga-Eun Kim, Clara Yongjoo Park, Min-Jeong Shin
  Nutrients.2022; 14(8): 1644.     CrossRef
• Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects
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  British Journal of Cancer.2022; 127(3): 549.     CrossRef
• Cardiovascular Risk and Treatment Outcomes in Severe Hypercholesterolemia: A Nationwide Cohort Study
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  Journal of the American Heart Association.2022;[Epub]     CrossRef
• Association between Smoking Status and Incident Non-Cystic Fibrosis Bronchiectasis in Young Adults: A Nationwide Population-Based Study
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  Journal of Personalized Medicine.2022; 12(5): 691.     CrossRef
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  Journal of Clinical Oncology.2022; 40(29): 3394.     CrossRef
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• Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study
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  Journal of Lipid and Atherosclerosis.2022; 11(2): 178.     CrossRef
• Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
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  Frontiers in Neurology.2022;[Epub]     CrossRef
• Risk Factors of Incident Lung Cancer in Patients with Non-Cystic Fibrosis Bronchiectasis: A Korean Population-Based Study
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  Cancers.2022; 14(11): 2604.     CrossRef
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  Hypertension.2022; 79(7): 1466.     CrossRef
• Risk of secondary nonhematologic malignancies after allogeneic stem cell transplantation: A nationwide case‐control cohort study
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  Scientific Reports.2022;[Epub]     CrossRef
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  Scientific Reports.2022;[Epub]     CrossRef
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  Gastroenterology.2022; 163(3): 637.     CrossRef
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  Yonsei Medical Journal.2022; 63(8): 774.     CrossRef
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  Scientific Reports.2022;[Epub]     CrossRef
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  Journal of Personalized Medicine.2022; 12(8): 1260.     CrossRef
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• Traditional medicine for the treatment of common cold in Korean adults: A nationwide population-based study
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• The Population Prevalence, Associations of Congenital Heart Defect and Mortality Risk for Down’s Syndrome in South Korea Based on National Health Insurance Service (NHIS) Data

  
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Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic disorder, and a major public health problem that is rapidly increasing in prevalence. Although a wide range of pharmacotherapies for glycemic control is now available, management of T2DM remains complex and challenging. The kidneys contribute immensely to glucose homeostasis by reabsorbing glucose from the glomerular filtrate. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, a new class of antidiabetic agents that inhibit glucose absorption from the kidney independent of insulin, offer a unique opportunity to improve the outcomes of patients with T2DM. In this review, we provide an overview of two globally-approved SGLT2 inhibitors, dapagliflozin and canagliflozin, and discuss their effects and safety. This information will help clinicians to decide whether these drugs will benefit their patients.

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Mitochondria play key roles in energy production and intracellular reactive oxygen species (ROS) generation. Lines of evidence have shown that mitochondrial dysfunction contributes to the development of metabolic syndrome. The causes of mitochondrial dysfunction are complex, but overnutrition and sedentary living are among the best known causes of mitochondrial dysfunction. ATP synthesized in the mitochondria is exchanged for cytosolic ADP by adenine nucleotide translocator (ANT) to provide a continuous supply of ADP to mitochondria. We recently found that ANT function is essential for peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α)'s action on endothelial cells. PGC-1α is a transcriptional coactivator of nuclear receptors, playing an important role in fatty acid oxidation and mitochondrial biogenesis. Recent studies have shown that PGC-1α decreases intracellular ROS generation by increasing the expression of antioxidant genes. In our study, PGC-1α reduced cell apoptosis and ROS generation in endothelial cells by increasing ATP/ADP translocase activity of ANT and ANT1 expression. Here we review the role of ANT in maintaining proper mitochondrial function, and possible role of ANT dysfunction in the pathogenesis of metabolic syndrome.

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Citations

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