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Review
- Basic Research
- Rediscovering Primary Cilia in Pancreatic Islets
- Eun Young Lee, Jing W. Hughes
- Diabetes Metab J. 2023;47(4):454-469. Published online April 28, 2023
- DOI: https://doi.org/10.4093/dmj.2022.0442
- 11,728 View
- 350 Download
- 13 Web of Science
- 13 Crossref
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Abstract
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ePub - Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades. In pancreatic islets as in other tissues, primary cilia facilitate crucial developmental and signaling pathways in response to extracellular stimuli. Many human developmental and genetic disorders are associated with ciliary dysfunction, some manifesting as obesity and diabetes. Understanding the basis for metabolic diseases in human ciliopathies has been aided by close examination of cilia action in pancreatic islets at cellular and molecular levels. In this article, we review the evidence for ciliary expression on islet cells, known roles of cilia in pancreas development and islet hormone secretion, and summarize metabolic manifestations of human ciliopathy syndromes. We discuss emerging data on primary cilia regulation of islet cell signaling and the structural basis of cilia-mediated cell crosstalk, and offer our interpretation on the role of cilia in glucose homeostasis and human diseases.
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Citations
Citations to this article as recorded by
- Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis
Elena Casanueva-Álvarez, Alba Sanz-González, Alicia Vilas, Patricia Cámara-Torres, Magalie A. Ravier, Sara Eslava-Alcon, M. Carmen Duran-Ruiz, Cristina M. Ramírez, Peristera-Ioanna Petropoulou, Teresa Rodriguez-Calvo, Beatriz Merino, Germán Perdomo, Irene
Molecular Medicine.2026;[Epub] CrossRef - Primary cilia dysfunction: A critical driver of metabolic diseases (Review)
Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
International Journal of Molecular Medicine.2026; 58(1): 1. CrossRef - Molecular mechanisms of the obesity associated with Bardet‐Biedl syndrome: An update
Bang‐Hua Zhong, Ning Nie, Ming Dong
Obesity Reviews.2025;[Epub] CrossRef - ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance
Eunice N Kim, Feng-Qian Li, Ken-Ichi Takemaru
Life Science Alliance.2025; 8(2): e202402916. CrossRef - Synchronized temporal-spatial analysis via microscopy and phosphoproteomics (STAMP) of quiescence
Mohammad Ovais Azizzanjani, Rachel E. Turn, Anushweta Asthana, Karen Y. Linde-Garelli, Lucy Artemis Xu, Leilani E. Labrie, Mohammadamin Mobedi, Peter K. Jackson
Science Advances.2025;[Epub] CrossRef - Roles of primary cilia in cell death
Sheng Chen, Chao Chen, Mingjue Chen, Feiyun Li, Chao Xie, Zengwu Shao, Guozhi Xiao
Oral Science and Homeostatic Medicine.2025; 1(3): 9610030. CrossRef - The NME7 Gene Is Involved in the Kinetics of Glucose Processing
Daniela Vejražková, Josef Včelák, Markéta Vaňková, Petra Lukášová, Michaela Svojtková, Tereza Grimmichová, Hana Kvasničková, Andrea Tura, Lucie Šedová, Ondřej Šeda, Kateřina Škultéty, Běla Bendlová
International Journal of Molecular Sciences.2025; 26(19): 9821. CrossRef - The role of the primary cilium in thyroid function and dysfunction with implications for thyroid disease
Inés Martín-Lacave, Victoria Vázquez-Román, Beatriz Pérez-Fernández, José María Fernández-Santos
Histochemistry and Cell Biology.2025;[Epub] CrossRef - Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus
Asma A Elashi, Salman M Toor, Umm-Kulthum Ismail Umlai, Yasser A Al-Sarraj, Shahrad Taheri, Karsten Suhre, Abdul Badi Abou-Samra, Omar M E Albagha
BMC Medical Genomics.2024;[Epub] CrossRef - Reduced Nephrin Tyrosine Phosphorylation Enhances Insulin Secretion and Increases Glucose Tolerance With Age
Casey R Williamson, Nina Jones
Endocrinology.2024;[Epub] CrossRef - Beta-Hydroxybutyrate Promotes Basal Insulin Secretion While Decreasing Glucagon Secretion in Mouse and Human Islets
Risha Banerjee, Ying Zhu, George P Brownrigg, Renata Moravcova, Jason C Rogalski, Leonard J Foster, James D Johnson, Jelena Kolic
Endocrinology.2024;[Epub] CrossRef - Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus
Shengnan Huang, Fangfang Li, Chunhua Quan, Dan Jin
Gut Microbes.2024;[Epub] CrossRef - Beta cell primary cilia mediate somatostatin responsiveness via SSTR3
Samantha E. Adamson, Zipeng A. Li, Jing W. Hughes
Islets.2023;[Epub] CrossRef
- Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis
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