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Islet Studies and Transplantation
Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5
Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Jae-Han Jeon, Nam Doo Kim, Keun-Gyu Park, Kyu Chang Won, Jaechan Leem, In-Kyu Lee
Diabetes Metab J. 2019;43(2):192-205.   Published online January 16, 2019
DOI: https://doi.org/10.4093/dmj.2018.0052
  • 5,209 View
  • 107 Download
  • 34 Web of Science
  • 36 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic conditions. However, little is known about how CDK5 impair β-cell function. Myricetin, a natural flavonoid, has therapeutic potential for the treatment of type 2 diabetes mellitus. In this study, we examined the effect of myricetin on high glucose (HG)-induced β-cell apoptosis and explored the relationship between myricetin and CDK5.

Methods

To address this question, we subjected INS-1 cells and isolated rat islets to HG conditions (30 mM) in the presence or absence of myricetin. Docking studies were conducted to validate the interaction between myricetin and CDK5. Gene expression and protein levels of endoplasmic reticulum (ER) stress markers were measured by real-time reverse transcription polymerase chain reaction and Western blot analysis.

Results

Activation of CDK5 in response to HG coupled with the induction of ER stress via the down regulation of sarcoendoplasmic reticulum calcium ATPase 2b (SERCA2b) gene expression and reduced the nuclear accumulation of pancreatic duodenal homeobox 1 (PDX1) leads to β-cell apoptosis. Docking study predicts that myricetin inhibit CDK5 activation by direct binding in the ATP-binding pocket. Myricetin counteracted the decrease in the levels of PDX1 and SERCA2b by HG. Moreover, myricetin attenuated HG-induced apoptosis in INS-1 cells and rat islets and reduce the mitochondrial dysfunction by decreasing reactive oxygen species production and mitochondrial membrane potential (Δψm) loss.

Conclusion

Myricetin protects the β-cells against HG-induced apoptosis by inhibiting ER stress, possibly through inactivation of CDK5 and consequent upregulation of PDX1 and SERCA2b.

Citations

Citations to this article as recorded by  
  • Profiling of secondary metabolite and evaluation of anti-diabetic potency of Crotalaria quinquefolia (L): In-vitro, in-vivo, and in-silico approaches
    Nazmun Nahar, Md. Nazmul Hasan Zilani, Partha Biswas, Md. Morsaline Billah, Shabana Bibi, Norah A. Albekairi, Abdulrahman Alshammari, Md. Nazmul Hasan
    Saudi Pharmaceutical Journal.2024; 32(1): 101887.     CrossRef
  • Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
    Udayakumar Karunakaran, Suma Elumalai, Seung Min Chung, Kathrin Maedler, Kyu Chang Won, Jun Sung Moon
    Redox Biology.2024; 69: 102994.     CrossRef
  • Network-based identification and mechanism exploration of active ingredients against Alzheimer’s disease via targeting endoplasmic reticulum stress from traditional chinese medicine
    Zhao Dai, Tian Hu, Junwen Wei, Xue Wang, Chuipu Cai, Yong Gu, Yunhui Hu, Wenjia Wang, Qihui Wu, Jiansong Fang
    Computational and Structural Biotechnology Journal.2024; 23: 506.     CrossRef
  • Myricetin as a Promising Flavonoid with Multitargeted Biological Activity
    A.S. Chiriapkin
    Juvenis Scientia.2024; 10(1): 5.     CrossRef
  • Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response
    Daniela Correia da Silva, Patrícia Valentão, David M. Pereira
    Journal of Physiology and Biochemistry.2024; 80(2): 421.     CrossRef
  • Immunopeptidome mining reveals a novel ERS-induced target in T1D
    Lina Wang, Shushu Yang, Gaohui Zhu, Jie Li, Gang Meng, Xiaoling Chen, Mengjun Zhang, Shufeng Wang, Xiangqian Li, Yu Pan, Yi Huang, Li Wang, Yuzhang Wu
    Cellular & Molecular Immunology.2024; 21(6): 604.     CrossRef
  • مقارنة تأثير المستخلص المائي لثمار نبات البامية Abelmoschus Esculentus مع عقار الميتفورمين على إناث الجرذان المصابة بالسكري
    عائشة أدريس, إبراهيم عزاقة, فاطمة عبدالله
    Journal of Pure & Applied Sciences .2024; 23(1): 96.     CrossRef
  • Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids
    Kingsley C. Mbara, Marthe C.D. Fotsing, Derek T. Ndinteh, Claudine N. Mbeb, Chinekwu S. Nwagwu, Rene Khan, Kopang C. Mokhetho, Himansu Baijnath, Manimbulu Nlooto, Shoeshoe Mokhele, Carmen M. Leonard, Vuyelwa J. Tembu, Clemence Tarirai
    Current Research in Pharmacology and Drug Discovery.2024; 6: 100184.     CrossRef
  • Myricetin Restores Autophagy to Attenuate Lumbar Intervertebral Disk Degeneration Via Negative Regulation of the JAK2/STAT3 Pathway
    Tian Mao, Junchi Fan
    Biochemical Genetics.2024;[Epub]     CrossRef
  • Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?
    Yao Chen, Xuejiao Qie, Wei Quan, Maomao Zeng, Fang Qin, Jie Chen, Benu Adhikari, Zhiyong He
    Critical Reviews in Food Science and Nutrition.2023; 63(20): 4288.     CrossRef
  • Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes
    Heui Min Lim, See-Hyoung Park
    Critical Reviews in Food Science and Nutrition.2023; 63(22): 5911.     CrossRef
  • Bioactive compounds from Polygonatum genus as anti-diabetic agents with future perspectives
    Yan Shi, Dun Si, Donghong Chen, Xinfeng Zhang, Zhigang Han, Qiang Yu, Jingjing Liu, Jinping Si
    Food Chemistry.2023; 408: 135183.     CrossRef
  • Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?
    Michele Lodato, Valérie Plaisance, Valérie Pawlowski, Maxime Kwapich, Alexandre Barras, Emeline Buissart, Stéphane Dalle, Sabine Szunerits, Jérôme Vicogne, Rabah Boukherroub, Amar Abderrahmani
    Cells.2023; 12(6): 940.     CrossRef
  • TFP5 attenuates cyclin‐dependent kinase 5‐mediated islet β‐cell damage in diabetes
    Shunyao Liu, Bo Li, Danna Ma, Yuejia Tao, Jiang Song, Li Bao, Guoqing Zhang, Hongyan Luo, Shilu Cao, Jing E, Yali Zheng
    Chemical Biology & Drug Design.2023; 102(1): 76.     CrossRef
  • Antiviral and Possible Prophylactic Significance of Myricetin for COVID-19
    Pawan K. Agrawal, Chandan Agrawal, Gerald Blunden
    Natural Product Communications.2023; 18(4): 1934578X2311662.     CrossRef
  • In Vitro and In Silico Protocols for the Assessment of Anti-Tick Compounds from Pinus roxburghii against Rhipicephalus (Boophilus) microplus Ticks
    Sana Ayub, Nosheen Malak, Raquel Cossío-Bayúgar, Nasreen Nasreen, Afshan Khan, Sadaf Niaz, Adil Khan, Abdallah D. Alanazi, Mourad Ben Said
    Animals.2023; 13(8): 1388.     CrossRef
  • Protective Effect of Myricetin Against Experimentally Induced Torsion in Rats
    M. Tatar, Z. Polat, J. Öner, H. Öner
    Biology Bulletin.2023; 50(6): 1338.     CrossRef
  • The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease
    Cuiting Wei, Chao Wang, Run Li, Yunfeng Bai, Xue Wang, Qingyun Fang, Xiangmei Chen, Ping Li
    Heliyon.2023; 9(11): e22017.     CrossRef
  • Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases
    Jana Viskupicova, Petronela Rezbarikova
    Molecules.2022; 27(16): 5095.     CrossRef
  • Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
    SuFang You, JingYi Zheng, YuPing Chen, HuiBin Huang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Myricetin inhibits pseudorabies virus infection through direct inactivation and activating host antiviral defense
    Huaiyue Hu, Zhiqiang Hu, Yingying Zhang, Hongping Wan, Zhongqiong Yin, Lixia Li, Xiaoxia Liang, Xinghong Zhao, Lizi Yin, Gang Ye, Yuan-Feng Zou, Huaqiao Tang, Renyong Jia, Yaqin Chen, Hao Zhou, Xu Song
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Effects of myricetin against cadmium-induced neurotoxicity in PC12 cells
    Azadeh Aminzadeh, Ayda Salarinejad
    Toxicology Research.2021; 10(1): 84.     CrossRef
  • Pioglitazone-induced AMPK-Glutaminase-1 prevents high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system
    Udayakumar Karunakaran, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Redox Biology.2021; 45: 102029.     CrossRef
  • Chlorogenic acid and β-glucan from highland barley grain ameliorate β-cell dysfunction via inhibiting apoptosis and improving cell proliferation
    Ze-Hua Liu, Bo Li
    Food & Function.2021; 12(20): 10040.     CrossRef
  • The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
    Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
    Scientific Reports.2021;[Epub]     CrossRef
  • AdipoRon promotes diabetic fracture repair through endochondral ossification-based bone repair by enhancing survival and differentiation of chondrocytes
    Zhongyi Wang, Jinxin Tang, Ying Li, Yu Wang, Yanyang Guo, Qisheng Tu, Jake Chen, Chen Wang
    Experimental Cell Research.2020; 387(2): 111757.     CrossRef
  • A kinase of many talents: non-neuronal functions of CDK5 in development and disease
    Samanta Sharma, Piotr Sicinski
    Open Biology.2020; 10(1): 190287.     CrossRef
  • Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus
    Luis Sobrevia, Paola Valero, Adriana Grismaldo, Roberto Villalobos-Labra, Fabián Pardo, Mario Subiabre, Gael Armstrong, Fernando Toledo, Sofía Vega, Marcelo Cornejo, Gonzalo Fuentes, Reinaldo Marín
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(12): 165948.     CrossRef
  • Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
    Yasaman Taheri, Hafiz Ansar Rasul Suleria, Natália Martins, Oksana Sytar, Ahmet Beyatli, Balakyz Yeskaliyeva, Gulnaz Seitimova, Bahare Salehi, Prabhakar Semwal, Sakshi Painuli, Anuj Kumar, Elena Azzini, Miquel Martorell, William N. Setzer, Alfred Maroyi,
    BMC Complementary Medicine and Therapies.2020;[Epub]     CrossRef
  • Current Pharmacological Trends on Myricetin
    Gudiya Gupta, Mohd Aftab Siddiqui, Mohd Muazzam Khan, Mohd Ajmal, Rabiya Ahsan, Md Azizur Rahaman, Md Afroz Ahmad, Md Arshad, Mohammad Khushtar
    Drug Research.2020;[Epub]     CrossRef
  • Silencing cyclophilin A improves insulin secretion, reduces cell apoptosis, and alleviates inflammation as well as oxidant stress in high glucose-induced pancreatic β-cells via MAPK/NF-kb signaling pathway
    Tangying Li, Huibiao Quan, Huachuan Zhang, Leweihua Lin, Qianying Ou, Kaining Chen
    Bioengineered.2020; 11(1): 1047.     CrossRef
  • Endoplasmic reticulum stress contributes to NMDA-induced pancreatic β-cell dysfunction in a CHOP-dependent manner
    Xiao-Ting Huang, Wei Liu, Yong Zhou, Mei Sun, Chen-Chen Sun, Chen-Yu Zhang, Si-Yuan Tang
    Life Sciences.2019; 232: 116612.     CrossRef
  • Dapagliflozin rescues endoplasmic reticulum stress-mediated cell death
    Ryo Shibusawa, Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire C. Bastie, Akito Maeshima, Kyoichi Kaira, Masanobu Yamada
    Scientific Reports.2019;[Epub]     CrossRef
  • Myricetin prevents thapsigargin-induced CDK5-P66Shc signalosome mediated pancreatic β-cell dysfunction
    Udayakumar Karunakaran, Ji Eun Lee, Suma Elumalai, Jun Sung Moon, Kyu Chang Won
    Free Radical Biology and Medicine.2019; 141: 59.     CrossRef
  • CDK5: Key Regulator of Apoptosis and Cell Survival
    Rabih Roufayel, Nimer Murshid
    Biomedicines.2019; 7(4): 88.     CrossRef
  • Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus
    Kai Wang, Yu Su, Yuting Liang, Yanhui Song, Liping Wang
    International Journal of Molecular Sciences.2019; 20(6): 1517.     CrossRef
Complications
Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis
Jaechan Leem, Eun Hee Koh, Jung Eun Jang, Chang-Yun Woo, Jin Sun Oh, Min Jung Lee, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park, Ki-Up Lee
Diabetes Metab J. 2015;39(5):414-423.   Published online October 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.5.414
  • 4,437 View
  • 30 Download
  • 7 Web of Science
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AbstractAbstract PDFPubReader   
Background

The diagnosis of coronary artery disease (CAD) is often delayed in patients with type 2 diabetes. Serum total bilirubin levels are inversely associated with CAD. However, no studies have examined whether this can be used as a biochemical marker for identifying asymptomatic diabetic patients at higher risk for having obstructive CAD.

Methods

We performed a cross-sectional study of 460 consecutive asymptomatic patients with type 2 diabetes. All patients underwent coronary computed tomographic angiography, and their serum total bilirubin levels were measured. Obstructive CAD was defined as ≥50% diameter stenosis in at least one coronary artery.

Results

Serum total bilirubin tertiles showed an inverse association with the prevalence of obstructive CAD. In multivariate logistic regression analysis, the odds ratio for the highest versus the lowest tertile of total bilirubin was 0.227 (95% confidence interval [CI], 0.130 to 0.398), and an increment of 1 µmol/L in serum total bilirubin level was associated with a 14.6% decrease in obstructive CAD after adjustment for confounding variables. Receiver operating characteristic curve analysis showed that the area under the curve for the Framingham Risk Score (FRS) plus serum total bilirubin level was 0.712 (95% CI, 0.668 to 0.753), which is significantly greater than that of the FRS alone (P=0.0028).

Conclusion

Serum total bilirubin level is inversely associated with obstructive CAD and provides additive risk information over the FRS. Serum total bilirubin may be helpful for identifying asymptomatic patients with type 2 diabetes who are at higher risk for obstructive CAD.

Citations

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  • DECREASE IN SERUM BILIRUBIN AS AN UNFAVORABLE MARKER OF CARDIOVASCULAR DISORDERS
    L. M. Strilchuk, O. O. Zimba, I. B. Zhakun
    Eastern Ukrainian Medical Journal.2020; 8(3): 268.     CrossRef
  • Contemporary diagnostic algorithm for coronary artery disease: achievements and prospects
    A. S. Akselrod, D. Yu. Shchekochikhin, E. S. Tebenkova, A. V. Zhelankin, D. A. Stonogina, E. A. Syrkina, S. K. Ternovoy
    Kardiologiya i serdechno-sosudistaya khirurgiya.2019; 12(5): 418.     CrossRef
  • Pharmacological actions and therapeutic potentials of bilirubin in islet transplantation for the treatment of diabetes
    Qing Yao, Xue Jiang, Longfa Kou, Adelaide T. Samuriwo, He-Lin Xu, Ying-Zheng Zhao
    Pharmacological Research.2019; 145: 104256.     CrossRef
  • Evaluation of genetic effect of NOS3 and G×E interaction on the variability of serum bilirubin in a Han Chinese population
    Yingshui Yao, Zhengmei Fang, Song Yang, Hailong Zhao, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Lijun Zhu, Yuanrui Tian, Chong Shen
    Nitric Oxide.2017; 70: 25.     CrossRef
  • Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications
    Mark McCarty
    Healthcare.2017; 5(1): 15.     CrossRef
  • Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies
    Bo Zhu, Xiaomei Wu, Yifei Bi, Yang Yang
    Scientific Reports.2017;[Epub]     CrossRef
  • Role of Bilirubin in Diabetic Vascular Complications: Can Bilirubin Predict More than Just Liver Disease?
    Jun Sung Moon
    Diabetes & Metabolism Journal.2015; 39(5): 384.     CrossRef
Serum Ceruloplasmin Level as a Predictor for the Progression of Diabetic Nephropathy in Korean Men with Type 2 Diabetes Mellitus
Min Jung Lee, Chang Hee Jung, Yu Mi Kang, Jung Eun Jang, Jaechan Leem, Joong-Yeol Park, Woo Je Lee
Diabetes Metab J. 2015;39(3):230-239.   Published online April 22, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.3.230
  • 4,666 View
  • 48 Download
  • 24 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   
Background

Oxidative stress is known to be associated with progression of diabetic kidney disease. Ceruloplasmin acts as a pro-oxidant under conditions of severe oxidative stress. Thus, we conducted a longitudinal observational study to evaluate whether the serum ceruloplasmin level is a predictive biomarker for progression of diabetic nephropathy.

Methods

A total of 643 Korean men with type 2 diabetes mellitus were enrolled. Serum ceruloplasmin was measured using a nephelometric method. Progression of diabetic nephropathy was defined as transition in albuminuria class (i.e., normoalbuminuria to microalbuminuria, microalbuminuria to macroalbuminuria, or normoalbuminuria to macroalbuminuria) and/or a greater than 2-fold increase of serum creatinine at follow-up compared with the baseline value.

Results

During the follow-up period (median, 2.7 years; range, 0.3 to 4.4 years), 49 of 643 patients (7.6%) showed the progression of diabetic nephropathy and three patients (0.5%) developed end-stage renal disease. Baseline ceruloplasmin levels were higher in the progressors than in the nonprogressors (262.6±40.9 mg/L vs. 233.3±37.8 mg/L, P<0.001). Kaplan-Meier analysis showed a significantly higher incidence of nephropathy progression according to ceruloplasmin tertile (log-rank test, P<0.001). The hazard ratio (HR) for progression of diabetic nephropathy was significantly higher in the highest ceruloplasmin tertile category compared with the lowest ceruloplasmin tertile category, even after adjusting for confounding variables (HR, 3.32; 95% confidence interval, 1.28 to 8.61; P=0.003).

Conclusion

Baseline serum ceruloplasmin is an independent predictive factor for the progression of diabetic nephropathy in patients with type 2 diabetes mellitus.

Citations

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  • Proteomic analysis of urinary exosomes reveals ferroptosis-associated proteins are involved in diabetic nephropathy
    Kaida Mu, Yanping Yang, Xiaofei An, Jie Zhu, Jing Zhang, Yanfei Jiang, Xiaorong Yang, Jinan Zhang
    Genes & Diseases.2024; 11(5): 101138.     CrossRef
  • In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease
    Shichun Du, Linhui Zhai, Shu Ye, Le Wang, Muyin Liu, Minjia Tan
    Science China Life Sciences.2023; 66(11): 2587.     CrossRef
  • Serum Level of Ceruloplasmin, Angiotensin-Converting Enzyme and Transferrin as Markers of Severity in SARS-CoV-2 Infection in Patients with Type 2 Diabetes
    Patricia-Andrada Reștea, Ștefan Țigan, Laura Grațiela Vicaș, Luminița Fritea, Eleonora Marian, Tunde Jurca, Annamaria Pallag, Iulius Liviu Mureșan, Corina Moisa, Otilia Micle, Mariana Eugenia Mureșan
    Microbiology Research.2023; 14(4): 1670.     CrossRef
  • The nephropathy of sickle cell trait and sickle cell disease
    Kenneth I. Ataga, Santosh L. Saraf, Vimal K. Derebail
    Nature Reviews Nephrology.2022; 18(6): 361.     CrossRef
  • Integrated Analysis of Single-Cell RNA-seq and Bulk RNA-seq in the Identification of a Novel ceRNA Network and Key Biomarkers in Diabetic Kidney Disease
    Yuejun Wang, Mingming Zhao, Yu Zhang
    International Journal of General Medicine.2022; Volume 15: 1985.     CrossRef
  • Molecular Functions of Ceruloplasmin in Metabolic Disease Pathology
    Zhidong Liu, Miao Wang, Chunbo Zhang, Shigao Zhou, Guang Ji
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 695.     CrossRef
  • A correlative study of copper, ceruloplasmin, iron, total iron binding capacity and total antioxidant capacity in diabetic nephropathy
    Ramlingareddy, Shivashankara A Ramachandrayya, Jeena Jacob, Malathi Mala
    Biomedicine.2022; 42(3): 469.     CrossRef
  • Novel biomarkers for prognosticating diabetic kidney disease progression
    Shilna Muttickal Swaminathan, Indu Ramachandra Rao, Srinivas Vinayak Shenoy, Attur Ravindra Prabhu, Pooja Basthi Mohan, Dharshan Rangaswamy, Mohan V Bhojaraja, Shivashankara Kaniyoor Nagri, Shankar Prasad Nagaraju
    International Urology and Nephrology.2022; 55(4): 913.     CrossRef
  • Evaluation of Serum Ceruloplasmin Levels as a Biomarker for Oxidative Stress in Patients With Diabetic Retinopathy
    Gurunadh Satyanarayana, Narendra Keisham, Hitender S Batra, Subrahmanya Murti V, Mansur Khan, Sandeep Gupta, Vikram Mahindra
    Cureus.2021;[Epub]     CrossRef
  • Prospection of plasma proteins as biomarkers for diabetes mellitus monitoring
    Liliane de Paula Silva, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Marcelo Müller-Santos, Dayane Alberton
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 611.     CrossRef
  • Risk assessment for foot ulcers among Tunisian subjects with diabetes: a cross sectional outpatient study
    B. Zantour, S. Bouchareb, Z. El Ati, F. Boubaker, W. Alaya, W. Kossomtini, M. H. Sfar
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats
    Shuai Wang, Zhiyuan Lu, Yuxin Wang, Tianran Zhang, Xiaodong He
    Nutrition & Metabolism.2020;[Epub]     CrossRef
  • Emerging vistas on electrochemical detection of diabetic retinopathy biomarkers
    K.S. Shalini Devi, Madhurantakam Sasya, Uma Maheswari Krishnan
    TrAC Trends in Analytical Chemistry.2020; 125: 115838.     CrossRef
  • Oxidative stress in peritoneal dialysis patients: Association with the dialysis adequacy and technique survival
    Natalia Stepanova, Lesya Korol, Olena Burdeyna
    Indian Journal of Nephrology.2019; 29(5): 309.     CrossRef
  • Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management
    Veena Vijayakumar, Sushanta K. Samal, Smita Mohanty, Sanjay K. Nayak
    International Journal of Biological Macromolecules.2019; 122: 137.     CrossRef
  • Rat Böbrek Dokusunda Kurşunun Neden Olduğu Oksidatif Strese Karşı Kitosanın Koruyucu etkisi
    Ugur ÖZDEK, Hasan TOZ, Ahmet Ufuk KÖMÜROĞLU, Leyla MİS, Zübeyir HUYUT, Yeter DEĞER
    Van Veterinary Journal.2019; 30(3): 187.     CrossRef
  • Changes in Trace Elements During Early Stages of Chronic Kidney Disease in Type 2 Diabetic Patients
    Ching-Chiang Lin, Ching-Tang Shih, Chien-Hung Lee, Yeou-Lih Huang
    Biological Trace Element Research.2018; 186(2): 330.     CrossRef
  • The Divalent Elements Changes in Early Stages of Chronic Kidney Disease
    Wan-Ju Kung, Ching-Tang Shih, Chien-Hung Lee, Ching-Chiang Lin
    Biological Trace Element Research.2018; 185(1): 30.     CrossRef
  • Long-term expression of glomerular genes in diabetic nephropathy
    Dominik Chittka, Bernhard Banas, Laura Lennartz, Franz Josef Putz, Kathrin Eidenschink, Sebastian Beck, Thomas Stempfl, Christoph Moehle, Simone Reichelt-Wurm, Miriam C Banas
    Nephrology Dialysis Transplantation.2018;[Epub]     CrossRef
  • Incidence of chronic kidney disease among people with diabetes: a systematic review of observational studies
    D. N. Koye, J. E. Shaw, C. M. Reid, R. C. Atkins, A. T. Reutens, D. J. Magliano
    Diabetic Medicine.2017; 34(7): 887.     CrossRef
  • Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis
    Pengzi Zhang, Jing Lu, Yali Jing, Sunyinyan Tang, Dalong Zhu, Yan Bi
    Annals of Medicine.2017; 49(2): 106.     CrossRef
  • Biomarkers of diabetic nephropathy: A 2017 update
    Nektaria Papadopoulou-Marketou, Christina Kanaka-Gantenbein, Nikolaos Marketos, George P. Chrousos, Ioannis Papassotiriou
    Critical Reviews in Clinical Laboratory Sciences.2017; 54(5): 326.     CrossRef
  • Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes
    Hung-Yuan Li, Hung-An Lin, Feng-Jung Nien, Vin-Cent Wu, Yi-Der Jiang, Tien-Jyun Chang, Hsien-Li Kao, Mao-Shin Lin, Jung-Nan Wei, Cheng-Hsin Lin, Shyang-Rong Shih, Chi-Sheng Hung, Lee-Ming Chuang, Emmanuel A Burdmann
    PLOS ONE.2016; 11(2): e0147981.     CrossRef
Clinical Features and Causes of Endogenous Hyperinsulinemic Hypoglycemia in Korea
Chang-Yun Woo, Ji Yun Jeong, Jung Eun Jang, Jaechan Leem, Chang Hee Jung, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Joong-Yeol Park, Jung Bok Lee, Ki-Up Lee
Diabetes Metab J. 2015;39(2):126-131.   Published online March 9, 2015
DOI: https://doi.org/10.4093/dmj.2015.39.2.126
  • 5,484 View
  • 85 Download
  • 23 Web of Science
  • 20 Crossref
AbstractAbstract PDFPubReader   
Background

Endogenous hyperinsulinemic hypoglycemia (EHH) is characterized by an inappropriately high plasma insulin level, despite a low plasma glucose level. Most of the EHH cases are caused by insulinoma, whereas nesidioblastosis and insulin autoimmune syndrome (IAS) are relatively rare.

Methods

To evaluate the relative frequencies of various causes of EHH in Korea, we retrospectively analyzed 84 patients who were diagnosed with EHH from 1998 to 2012 in a university hospital.

Results

Among the 84 EHH patients, 74 patients (88%), five (6%), and five (6%) were diagnosed with insulinoma, nesidioblastosis or IAS, respectively. The most common clinical manifestation of EHH was neuroglycopenic symptoms. Symptom duration before diagnosis was 14.5 months (range, 1 to 120 months) for insulinoma, 1.0 months (range, 6 days to 7 months) for nesidioblastosis, and 2.0 months (range, 1 to 12 months) for IAS. One patient, who was diagnosed with nesidioblastosis in 2006, underwent distal pancreatectomy but was later determined to be positive for insulin autoantibodies. Except for one patient who was diagnosed in 2007, the remaining three patients with nesidioblastosis demonstrated severe hyperinsulinemia (157 to 2,719 µIU/mL), which suggests that these patients might have had IAS, rather than nesidioblastosis.

Conclusion

The results of this study suggest that the prevalence of IAS may be higher in Korea than previously thought. Therefore, measurement of insulin autoantibody levels is warranted for EHH patients, especially in patients with very high plasma insulin levels.

Citations

Citations to this article as recorded by  
  • Case report: Insulinomatosis: description of four sporadic cases and review of the literature
    Delmar Muniz Lourenço, Maria Lucia Corrêa-Giannella, Sheila Aparecida Coelho Siqueira, Marcia Nery, Flavio Galvão Ribeiro, Elizangela Pereira de Souza Quedas, Manoel de Souza Rocha, Ramon Marcelino do Nascimento, Maria Adelaide Albergaria Pereira
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Use of Translational Science, Continuous Glucose Monitoring in the Primary Care Setting for Management of Nesidioblastosis: A Case Report and Literature Review
    Karuna Manandhar, Othman Farahneh, Ahmad Damlakhy, Ali Lattouf, Gerardo Munoz Monaco
    Cureus.2024;[Epub]     CrossRef
  • Insulin Autoimmune Syndrome: A Systematic Review
    MingXu Lin, YuHua Chen, Jie Ning, Tatsuya Kin
    International Journal of Endocrinology.2023; 2023: 1.     CrossRef
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    Martin Philipp Dieterle, Ayman Husari, Sophie Nicole Prozmann, Hendrik Wiethoff, Albrecht Stenzinger, Manuel Röhrich, Uwe Pfeiffer, Wolfgang Rüdiger Kießling, Helena Engel, Harald Sourij, Thorsten Steinberg, Pascal Tomakidi, Stefan Kopf, Julia Szendroedi
    Biomedicines.2023; 11(6): 1732.     CrossRef
  • An Uncommon Cause of Recurrent Presyncope, Dizziness, and Tachycardia: A Case Report of Diffuse, Adult-Onset Nesidioblastosis/Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome (NIPHS)
    Martin Philipp Dieterle, Ayman Husari, Sophie Nicole Prozmann, Hendrik Wiethoff, Albrecht Stenzinger, Manuel Röhrich, Uwe Pfeiffer, Wolfgang Rüdiger Kießling, Helena Engel, Harald Sourij, Thorsten Steinberg, Pascal Tomakidi, Stefan Kopf, Julia Szendroedi
    Biomedicines.2023; 11(6): 1741.     CrossRef
  • An Uncommon Case of Recurrent Hypoglycemic Episodes in a Healthy Non-diabetic Male: Insulin Autoimmune Syndrome
    Kanwarpal K Dhaliwal, Gaurav Bector, Saurabh Arora, Amanpreet Singh, Sanjay Kalra
    Cureus.2023;[Epub]     CrossRef
  • The After-Dinner Dip
    Caren G. Solomon, Gertrud L.G. Haverkamp, Richard G. Ijzerman, Jos Kooter, Yvonne H.M. Krul-Poel
    New England Journal of Medicine.2022; 386(22): 2130.     CrossRef
  • Hirata's disease (insulin autoimmune syndrome) following envenomation by a common krait
    Subramanian Senthilkumaran, Stephen W. Miller, Harry F. Williams, Ponniah Thirumalaikolundusubramanian, Sakthivel Vaiyapuri, Ketan Patel
    Toxicon.2022; 219: 106923.     CrossRef
  • Analysis of the clinical characteristics of insulin autoimmune syndrome induced by methimazole
    Linli Sun, Weijin Fang, Dan Yi, Wei Sun, Chunjiang Wang
    Journal of Clinical Pharmacy and Therapeutics.2021; 46(2): 470.     CrossRef
  • Continuous glucose monitoring and Rituximab treatment in insulin autoimmune syndrome
    Hiya Boro, Uttio Gupta, Charandeep Singh, Rakhi Malhotra, Rajesh Khadgawat
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(6): 102294.     CrossRef
  • Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description


    Daniele Cappellani, Enrico Macchia, Alberto Falorni, Piero Marchetti
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 963.     CrossRef
  • Nationwide survey of endogenous hyperinsulinemic hypoglycemia in Japan (2017–2018): Congenital hyperinsulinism, insulinoma, non‐insulinoma pancreatogenous hypoglycemia syndrome and insulin autoimmune syndrome (Hirata’s disease)
    Yuki Yamada, Kana Kitayama, Maki Oyachi, Shinji Higuchi, Rie Kawakita, Yutaka Kanamori, Tohru Yorifuji
    Journal of Diabetes Investigation.2020; 11(3): 554.     CrossRef
  • Insulin Autoimmune Syndrome – A Case Series
    Hiya Boro, Uttio Gupta, Charandeep Singh, Rakhi Malhotra, Rajesh Khadgawat
    European Endocrinology.2020; 16(2): 168.     CrossRef
  • Management of Insulin Autoimmune Hypoglycaemia: Single‐centre experience from Western India with systematic review of world literature
    Muniraj Patel, Ravikumar Shah, Swati Ramteke‐Jadhav, Virendra Patil, Shivendra Kumar Patel, Anurag Lila, Nalini Shah, Tushar Bandgar
    Clinical Endocrinology.2020; 92(5): 409.     CrossRef
  • Is insulin intoxication still the perfect crime? Analysis and interpretation of postmortem insulin: review and perspectives in forensic toxicology
    Charline Bottinelli, Nathalie Cartiser, Fabien Bévalot, Laurent Fanton, Jérôme Guitton
    Critical Reviews in Toxicology.2020; 50(4): 324.     CrossRef
  • Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series
    Yimin Shen, Xiaoxiao Song, Yuezhong Ren
    BMC Endocrine Disorders.2019;[Epub]     CrossRef
  • An observational analysis of insulinoma from a single institution
    S Shao, Z Zeng, S Hu
    QJM: An International Journal of Medicine.2018; 111(4): 237.     CrossRef
  • Anti-tuberculosis Treatment-Induced Insulin Autoimmune Syndrome
    Jung Suk Han, Han Ju Moon, Jin Seo Kim, Hong Il Kim, Cheol Hyeon Kim, Min Joo Kim
    The Ewha Medical Journal.2016; 39(4): 122.     CrossRef
  • Spontaneous hypoglycemia: diagnostic evaluation and management
    Leelavathy Kandaswamy, Rajeev Raghavan, Joseph M. Pappachan
    Endocrine.2016; 53(1): 47.     CrossRef
  • Hypoglycemia due to Insulin Autoimmune Syndrome: A rare cause not to be forgotten
    Sarah Alam, Maaz Ozair, Jamal Ahmad
    Journal of Clinical and Translational Endocrinology: Case Reports.2016; 2: 7.     CrossRef

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