Diabetes & Metabolism Journal

Original Article

Guideline/Statement/Fact Sheet
Health Effects of Sugar-Sweetened and Artificially Sweetened Beverages: Umbrella Review and Evidence-Based Consensus Statement of the Korean Diabetes Association and the Korean Nutrition Society: Jong Han Choi, SuJin Song, Soo Kyoung Kim, Jae Won Cho, Jae Hyun Bae, Shinje Moon, Jeong Hyun Lim, YeonHee Lee, Ji-Yun Hwang, YoonJu Song, Sang Soo Kim; Diabetes Metab J. 2026;50(1):32-46. Published online January 1, 2026; DOI: https://doi.org/10.4093/dmj.2025.0848

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Background
Excess intake of added sugars contributes to obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and premature mortality. Sugar-sweetened beverages (SSBs), the main source of added sugars, are consistently linked to adverse outcomes. Artificially sweetened beverages (ASBs) have been suggested as short-term substitutes, but evidence regarding benefits and harms remains inconclusive, and guidance is lacking.
Methods
This consensus statement draws on a structured evidence review combining two approaches: an updated meta-analysis of randomized controlled trials (RCTs) assessing short- to intermediate-term effects of replacing SSBs with ASBs on weight and metabolic outcomes; and an umbrella review of systematic reviews of cohort studies evaluating long-term associations of SSBs and ASBs with major outcomes, including mortality, CVD, and T2DM.
Results
In 14 RCTs (3–76 weeks), replacing SSBs with ASBs produced modest reductions in body weight (–0.73 kg) and body fat (–0.72%), with inconsistent effects on glycemic and cardiometabolic markers. Evidence from 20 systematic reviews of cohorts (up to 34 years follow-up) showed that higher intake of both SSBs and ASBs was associated with increased risks of T2DM, CVD, and mortality, with relative risks for ASBs similar to those for SSBs.
Conclusion
ASBs may serve as a short-term substitution for individuals with high SSB intake, particularly those at elevated metabolic risk. However, regular or long-term use is not recommended due to uncertain safety and potential reinforcement of sweet preference. Public health strategies should emphasize reducing both SSBs and ASBs, prioritizing water and unsweetened beverages as the ultimate goal.

Citations

Citations to this article as recorded by

Do Not Replace Your Sugar, Simply Eat Less!
Jeehyun Lee, Sunghwan Suh
Diabetes & Metabolism Journal.2026; 50(1): 30. CrossRef
Diabetes in Bangladesh: The Role of Sugar-Sweetened Beverages
Mohammad R. Monjur
Bangladesh Journal of Endocrinology and Metabolism.2026;[Epub] CrossRef
Associations of lifestyle behaviors with overweight and obesity: a cross-sectional study in Shenzhen, China
Shaojuan Zhao, Leyao Tang, Ni Xiong, Liping Liang, Xin Yin Wu, Chuanning Yu, Xueling Wei, Xuanzhen Wu, Wenjie Dai
Frontiers in Nutrition.2026;[Epub] CrossRef
Differential associations of beverage consumption with diabetic retinopathy: a systematic review and dose-response meta-analysis of observational studies
Siyan Liu, Xuan Wang, Guojun Chao, Wei Lu, Qi Wu, Yuxin Lv, Shuangshuang Yi, Zhengzheng Wu, Jing Yan
Frontiers in Medicine.2026;[Epub] CrossRef
Sugar rationing in the first 1000 days of life and risk of frailty: evidence from a natural experiment
Rui Zhang, Yuelan Gao, Hong Li, Yuhan Wei, Wanyang Zhong, Kai Tong, Zhibo Sun
The Journal of nutrition, health and aging.2026; 30(7): 100883. CrossRef
Influencing adolescents' beverage choices: An experimental study on the role of autonomy support and the availability of healthier options
Roselinde L. van Nee, Ellen van Kleef, Hans C.M. van Trijp
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Factors Influencing Water and Sweet Beverage Purchasing Decisions and Behaviours Among Low-Income Households in Four Peri-Urban Communities in Accra: An Exploratory Study
Christopher Delali Amegah, Gloria Adobea Odei Obeng-Amoako, Shu Wen Ng, Monica Lambon-Quayefio, Seth Adu-Afarwuah
International Journal of Environmental Research and Public Health.2026; 23(6): 799. CrossRef
Ten-year trends in sugar-sweetened beverages consumption among Koreans, 2014–2023
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Reviews

Guideline/Statement/Fact Sheet
Bridging Evidence and Practice: A Consensus Statement from the Korean Diabetes Association on Diabetes Screening, Pharmacological Treatment and Severe Diabetes: Jong Han Choi, Shinae Kang, Soo-Kyung Kim, Won Jun Kim, Ji Min Kim, Jaehyun Bae, Jae-Seung Yun, Eonju Jeon, Young-Eun Kim, Jae Hyun Bae, Hun Jee Choe, Young Min Cho, Seung-Hyun Ko, Sang Yong Kim, Hae Jin Kim, You-Cheol Hwang, Min Kyong Moon, Suk Chon, Seon Mee Kang, Hyuk-Sang Kwon, Mi Kyung Kim, You-Bin Lee, Se Hee Min, Jung Hwan Park, Woo Je Lee, Bong-Soo Cha, Byung-Wan Lee; Diabetes Metab J. 2025;49(6):1155-1177. Published online November 1, 2025; DOI: https://doi.org/10.4093/dmj.2025.0978

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This Korean Diabetes Association (KDA) consensus statement bridges global evidence with the Korean clinical context, where large randomized and real-world data remain limited. Recommendations required ≥80% agreement by the committee of clinical practice guideline and approval by the board of directors. The statement comprises three domains: diabetes screening aligned with Korean epidemiology; pharmacologic management guided by pathophysiology and comorbidities; and a severity construct of “severe diabetes mellitus” that links complication-based staging with metabolic grading to match therapeutic intensity to disease complexity. Compared with prior KDA guidelines, this statement introduces substantive advances in three areas. First, screening recommendations are streamlined to emphasize risk-aligned, practical implementation rather than prescriptive test sequences. Second, pharmacologic management applies an individualized framework for drug selection that jointly considers pathophysiology and comorbidities. It operationalizes individualized selection by dominant pathophysiology (insulin resistance vs. insulin insufficiency) and coexisting conditions, and formalizes treatment dynamics—early combination, timely initiation of injectables, avoidance of overbasalization, and structured deintensification. It also prioritizes agents with proven cardiovascular and renal protection and elevates management of obesity and metabolic dysfunction-associated steatotic liver disease as central goals; clinically, insulin should be initiated promptly in hypercatabolic states or suspected islet failure, and technology-enabled care—including continuous glucose monitoring and automated insulin delivery—are integral across all stages. Third, the newly introduced severity construct underpins treatment-intensity decisions across domains without reiterating prescriptive algorithms. Collectively, these recommendations provide a coherent, context-appropriate framework for diabetes screening and management in Korea and identify priorities for future evidence generation.

Citations

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Diabetes Research and Clinical Practice.2026; 238: 113388. CrossRef

Guideline/Statement/Fact Sheet
Defining Severe Diabetes Mellitus: A Consensus Framework for Grading and Staging Diabetes Based on Pathophysiology and Complications: Jae Hyun Bae, Hun Jee Choe, Ye Seul Yang, Mi Hae Seo, Jong Han Choi, Gyuri Kim, Young Sang Lyu, Jeung Hun Han, Shinae Kang, Won Jun Kim, Kyung-Soo Kim, Young Min Cho, Bong Soo Cha, for the Severe Diabetes Mellitus Task Force of the Korean Diabetes Association; Diabetes Metab J. 2025;49(6):1141-1154. Published online October 28, 2025; DOI: https://doi.org/10.4093/dmj.2025.0739

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Diabetes mellitus comprises a heterogeneous group of metabolic disorders differing in etiology, clinical course, and outcomes. Traditional classifications, such as type 1 and type 2 diabetes mellitus, fail to capture the full heterogeneity, including variation in insulin deficiency, insulin resistance, and complication burden. To address these limitations, we propose the Diabetes Grade–Stage Classification, an integrated system that combines pathophysiology-based grading with complication-based staging. Grading quantifies metabolic dysfunction through the assessment of insulin deficiency and insulin resistance. In parallel, staging assesses the extent of target organ damage, particularly in the cardiovascular, renal, ocular, and nervous systems. Together, this framework enables a comprehensive assessment of disease status, identification of vulnerable or high-risk phenotypes, and implementation of risk-adapted management strategies. Clinically, it facilitates personalized care, promotes collaborative coordination, and strengthens physician–patient communication. Furthermore, this framework provides a scalable structure for integrating disease severity into both individual- and population-level interventions. Although the current criteria for grading and staging are based on expert consensus and selected clinical indicators, such as low C-peptide levels and advanced complications, further validation and refinement are needed. In conclusion, the grading and staging system provides an operational tool for classifying the severity of diabetes mellitus and has the potential to extend life expectancy and improve quality of life for people living with diabetes mellitus.

Citations

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Material-driven glucose responsiveness in insulin delivery systems: carrier selection and performance
Zhihan Li, Jingge Jiang, Ziyu Zhu, Cheng Luo, Chunyi Xu, Chuanpin Chen, Guoqin Ren, Ruofei Huang, Dongjuan He
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Circulating GDF15 levels reflect metabolic and inflammatory burden in early dysglycemia: findings from the ADIOS cohort
Ji Yoon Kim, Ah Hyeon Lee, Jiyoon Lee, Hye-Min Jang, Sin Gon Kim, Dong-Hoon Kim, Nam Hoon Kim
Diabetes Research and Clinical Practice.2026; 239: 113461. CrossRef
Bridging Evidence and Practice: A Consensus Statement from the Korean Diabetes Association on Diabetes Screening, Pharmacological Treatment and Severe Diabetes
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Diabetes & Metabolism Journal.2025; 49(6): 1155. CrossRef

Original Article

Guideline/Statement/Fact Sheet
2025 Clinical Practice Guidelines for Diabetes Management in Korea: Recommendation of the Korean Diabetes Association: Shinae Kang, Seon Mee Kang, Jong Han Choi, Seung-Hyun Ko, Bo Kyung Koo, Hyuk-Sang Kwon, Mi Kyung Kim, Sang Yong Kim, Soo-Kyung Kim, Young-eun Kim, Eun Sook Kim, Jae Hyeon Kim, Chong Hwa Kim, Ji Min Kim, Hae Jin Kim, Min Kyong Moon, Sun Joon Moon, Jun Sung Moon, Joon Ho Moon, Se Hee Min, Jung Hwan Park, Jaehyun Bae, Keeho Song, Ji Yoon Ahn, Jae-Seung Yun, Woo Je Lee, You-Bin Lee, Suk Chon, Eonju Jeon, Sang-Man Jin, Eugene Han, You-Cheol Hwang, Jae Hyun Bae, YoonJu Song, Jeong Hyun Lim, Jae Won Cho, Ji Yeon Choi, Yong Hee Hong, Jieun Lee, Sung Eun Kim, Ji Yun Noh, Bong-Soo Cha, Byung-Wan Lee; Diabetes Metab J. 2025;49(4):582-783. Published online July 1, 2025; DOI: https://doi.org/10.4093/dmj.2025.0469

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Review

Pharmacotherapy
SGLT2 Inhibitors and GLP-1 Receptor Agonists in Diabetic Kidney Disease: Evolving Evidence and Clinical Application: Jae Hyun Bae; Diabetes Metab J. 2025;49(3):386-402. Published online May 1, 2025; DOI: https://doi.org/10.4093/dmj.2025.0220

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Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease and significantly increases cardiovascular risk and mortality. Despite conventional therapies, including renin-angiotensin-aldosterone system inhibitors, substantial residual risk remains. The emergence of sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists has reshaped DKD management. Beyond glycemic control, these agents provide distinct and complementary cardiorenal benefits through mechanisms such as hemodynamic modulation, anti-inflammatory effects, and metabolic adaptations. Landmark trials, including CREDENCE, DAPA-CKD, EMPA-KIDNEY, and FLOW, have demonstrated their efficacy in preserving kidney function and reducing adverse outcomes. SGLT2 inhibitors appear more effective in mitigating glomerular hyperfiltration and lowering heart failure risk, whereas GLP-1 receptor agonists are particularly beneficial in reducing albuminuria and atherosclerotic cardiovascular events. Although indirect comparisons suggest that SGLT2 inhibitors may offer greater protection against kidney function decline, direct head-to-head trials are lacking. Combination therapy holds promise, however further studies are needed to define optimal treatment strategies. This review synthesizes current evidence, evaluates comparative effectiveness, and outlines future directions in DKD management, emphasizing precision medicine approaches to enhance clinical outcomes. The integration of these therapies represents a paradigm shift in diabetes care, expanding treatment options for people with diabetes mellitus at risk of kidney failure.

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Hypertension Research.2026; 49(3): 816. CrossRef
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The American Journal of Medicine.2026; 139(6): 769. CrossRef
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Original Article

Lifestyle
Enhancing Diabetes Care through a Mobile Application: A Randomized Clinical Trial on Integrating Physical and Mental Health among Disadvantaged Individuals: Jae Hyun Bae, Eun Hee Park, Hae Kyung Lee, Kun Ho Yoon, Kyu Chang Won, Hyun Mi Kim, Sin Gon Kim; Diabetes Metab J. 2024;48(4):790-801. Published online February 2, 2024; DOI: https://doi.org/10.4093/dmj.2023.0298

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Background
This study examines integrating physical and mental healthcare for disadvantaged persons with type 2 diabetes mellitus and mild-to-moderate depression in the community, using a mobile application within a public-private-academic partnership.
Methods
The Korean Diabetes Association has developed a mobile application combining behavioral activation for psychological well-being and diabetes self-management, with conventional medical therapy. Participants were randomly assigned to receive the application with usual care or only usual care. Primary outcomes measured changes in psychological status and diabetes selfmanagement through questionnaires at week 12 from the baseline. Secondary outcomes assessed glycemic and lipid control, with psychological assessments at week 16.
Results
Thirty-nine of 73 participants completed the study (20 and 19 in the intervention and control groups, respectively) and were included in the analysis. At week 12, the intervention group showed significant reductions in depression severity and perceived stress compared to the control group. Additionally, they reported increased perceived social support and demonstrated improved diabetes self-care behavior. These positive effects persisted through week 16, with the added benefit of reduced anxiety. While fasting glucose levels in the intervention group tended to improve, no other significant differences were observed in laboratory assessments between the groups.
Conclusion
This study provides compelling evidence for the potential efficacy of a mobile application that integrates physical and mental health components to address depressive symptoms and enhance diabetes self-management in disadvantaged individuals with type 2 diabetes mellitus and depression. Further research involving larger and more diverse populations is warranted to validate these findings and solidify their implications.

Citations

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Review of Managerial Science.2026; 20(6): 2001. CrossRef
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Journal of Affective Disorders.2026; 393: 120297. CrossRef
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Journal of Endocrinological Investigation.2026; 49(7): 1683. CrossRef
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Courtney L. Ortz, Meredith S. Duncan, Oluwatosin Leshi, Suraksha Khanal, Brittany L. Smalls
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Letter

Altered Metabolic Phenotypes and Hypothalamic Neuronal Activity Triggered by Sodium-Glucose Cotransporter 2 Inhibition (Diabetes Metab J 2023;47:784-95): Jae Hyun Bae; Diabetes Metab J. 2024;48(1):157-158. Published online January 29, 2024; DOI: https://doi.org/10.4093/dmj.2022.0430

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Original Articles

Guideline/Fact Sheet
Dyslipidemia Fact Sheet in South Korea, 2022: Eun-Sun Jin, Jee-Seon Shim, Sung Eun Kim, Jae Hyun Bae, Shinae Kang, Jong Chul Won, Min-Jeong Shin, Heung Yong Jin, Jenny Moon, Hokyou Lee, Hyeon Chang Kim, In-Kyung Jeong, on Behalf of the Committee of Public Relation of the Korean Society of Lipid and Atherosclerosis; Diabetes Metab J. 2023;47(5):632-642. Published online August 2, 2023; DOI: https://doi.org/10.4093/dmj.2023.0135

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Background
This study aimed to investigate the prevalence and status of dyslipidemia management among South Korean adults, as performed by the Korean Society of Lipid and Atherosclerosis under the name Dyslipidemia Fact Sheet 2022.
Methods
We analyzed the lipid profiles, age-standardized and crude prevalence, management status of hypercholesterolemia and dyslipidemia, and health behaviors among Korean adults aged ≥20 years, using the Korea National Health and Nutrition Examination Survey data between 2007 and 2020.
Results
In South Korea, the crude prevalence of hypercholesterolemia (total cholesterol ≥240 mg/dL or use of a lipid-lowering drug) in 2020 was 24%, and the age-standardized prevalence of hypercholesterolemia more than doubled from 2007 to 2020. The crude treatment rate was 55.2%, and the control rate was 47.7%. The crude prevalence of dyslipidemia—more than one out of three conditions (low-density lipoprotein cholesterol ≥160 or the use of a lipid-lowering drug, triglycerides ≥200, or high-density lipoprotein cholesterol [HDL-C] [men and women] <40 mg/dL)—was 40.2% between 2016 and 2020. However, it increased to 48.2% when the definition of hypo-HDL-cholesterolemia in women changed from <40 to <50 mg/dL.
Conclusion
Although the prevalence of hypercholesterolemia and dyslipidemia has steadily increased in South Korea, the treatment rate remains low. Therefore, continuous efforts are needed to manage dyslipidemia through cooperation between the national healthcare system, patients, and healthcare providers.

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Guideline/Fact Sheet
Diabetes Fact Sheet in Korea 2021: Jae Hyun Bae, Kyung-Do Han, Seung-Hyun Ko, Ye Seul Yang, Jong Han Choi, Kyung Mook Choi, Hyuk-Sang Kwon, Kyu Chang Won, on Behalf of the Committee of Media-Public Relation of the Korean Diabetes Association; Diabetes Metab J. 2022;46(3):417-426. Published online May 25, 2022; DOI: https://doi.org/10.4093/dmj.2022.0106

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Abstract PDF Supplementary Material PubReader ePub

Background
This study aimed to investigate the prevalence and management of diabetes mellitus, risk-factor control, and comorbidities among Korean adults.
Methods
We conducted a cross-sectional analysis of data from the Korea National Health and Nutrition Examination Survey to assess the prevalence, treatment, risk factors, comorbidities, and self-management behaviors of diabetes mellitus from 2019 to 2020. We also analyzed data from the Korean National Health Insurance Service to evaluate the use of antidiabetic medications in people with diabetes mellitus from 2002 through 2018.
Results
Among Korean adults aged 30 years or older, the estimated prevalence of diabetes mellitus was 16.7% in 2020. From 2019 through 2020, 65.8% of adults with diabetes mellitus were aware of the disease and treated with antidiabetic medications. The percentage of adults with diabetes mellitus who achieved glycosylated hemoglobin (HbA1c) <6.5% was 24.5% despite the increased use of new antidiabetic medications. We found that adults with diabetes mellitus who achieved all three goals of HbA1c <6.5%, blood pressure (BP) <140/85 mm Hg, and low-density lipoprotein cholesterol <100 mg/dL were 9.7%. The percentage of self-management behaviors was lower in men than women. Excess energy intake was observed in 16.7% of adults with diabetes mellitus.
Conclusion
The prevalence of diabetes mellitus among Korean adults remained high. Only 9.7% of adults with diabetes mellitus achieved all glycemic, BP, and lipid controls from 2019 to 2020. Continuous evaluation of national diabetes statistics and a national effort to increase awareness of diabetes mellitus and improve comprehensive diabetes care are needed.

Citations

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Susanna Jun, Ji Won Kang, Dong-Hyuk Park, Ki-Yong An, Dong Hoon Lee, Minsuk Oh, Justin Y. Jeon
Yonsei Medical Journal.2026; 67(1): 71. CrossRef
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J. Stephy John, P. Metilda
Biochemical and Biophysical Research Communications.2026; 797: 153131. CrossRef
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Eun-Kyeong Yun, Jae Yong Shim, Sang-Jun Shin, Hee-Taik Kang
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Journal of Diabetes and its Complications.2026; 40(2): 109251. CrossRef
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Min Seok Kim, Seonghee Nam, Jeongwoo Lee, Se Joon Woo
Journal of Korean Medical Science.2026;[Epub] CrossRef
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Aida Kabibulatova, Kamilla Mussina, Joseph Almazan, Antonio Sarria-Santamera, Alessandro Salustri, Kuralay Atageldiyeva
Medical Sciences.2026; 14(1): 52. CrossRef
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Mi Ah Han
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BMC Public Health.2026;[Epub] CrossRef
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Woorim Kim, Kyujin Chang, Soon Young Lee, Yeong Jun Ju
BMC Health Services Research.2026;[Epub] CrossRef
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Ibrahim Mssillou, Youness El Abdali, Olja Šovljanski, Meryem Bakour, Hassan Laaroussi, Youssra Aghoutane, Edward. J. Calabrese, Asaad Khalid, Samah H. O. Zarroug, Boutaina Louafi, Dalila Bousta
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Endocrinology and Metabolism.2026; 41(1): 86. CrossRef
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Diabetes & Metabolism Journal.2025; 49(2): 225. CrossRef
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BMJ Open.2025; 15(3): e093598. CrossRef
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Frontiers in Nutrition.2025;[Epub] CrossRef
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Journal of Nutrition and Health.2025; 58(2): 179. CrossRef
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Korean Journal of Family Practice.2025; 15(2): 96. CrossRef
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Calcified Tissue International.2025;[Epub] CrossRef
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Diabetes, Obesity and Metabolism.2025; 27(9): 5019. CrossRef
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Scientific Reports.2025;[Epub] CrossRef
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Scientific Reports.2025;[Epub] CrossRef
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Endocrinology and Metabolism.2025; 40(3): 421. CrossRef
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Diabetes & Metabolism Journal.2025; 49(4): 582. CrossRef
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Djoko Priyono, Sanghee Kim
Science Progress.2025;[Epub] CrossRef
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The Journal of Allergy and Clinical Immunology: In Practice.2025; 13(8): 2025. CrossRef
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BMC Public Health.2025;[Epub] CrossRef
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Scientific Reports.2025;[Epub] CrossRef
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Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef
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Cancer Research and Treatment.2025; 57(4): 1178. CrossRef
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Diabetes Research and Clinical Practice.2025; 227: 112401. CrossRef
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Journal of Korean Medical Science.2025;[Epub] CrossRef
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PLOS One.2025; 20(8): e0329003. CrossRef
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The Korean Journal of Internal Medicine.2025; 40(5): 696. CrossRef
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Journal of Internal Medicine.2025; 298(4): 336. CrossRef
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Cardiovascular Diabetology – Endocrinology Reports.2025;[Epub] CrossRef
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Drug Design, Development and Therapy.2025; Volume 19: 7825. CrossRef
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The Journal of Internal Korean Medicine.2025; 46(3): 511. CrossRef
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Journal of Health Informatics and Statistics.2025; 50(3): 249. CrossRef
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Diabetes, Obesity and Metabolism.2025; 27(12): 7110. CrossRef
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Endocrinology and Metabolism.2025; 40(5): 727. CrossRef
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Cardiovascular Prevention and Pharmacotherapy.2025; 7(4): 120. CrossRef
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Seohyun Kim, Mira Kang, Dohyun Park, Gyuri Kim, Jae Hyeon Kim
BMC Public Health.2025;[Epub] CrossRef
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Jung-Yeon Choi, Cheol-Ho Kim, Kwang-il Kim
Cardiovascular Prevention and Pharmacotherapy.2025; 7(4): 135. CrossRef
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Acta Diabetologica.2025; 63(2): 209. CrossRef
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Hyeon-Jin Yu, Doyoun Hong, Kyuho Kim, Ji Hye Heo, Dong-Hyeok Cho, Yoshitaka Hashimoto, Jae-Seung Yun
Diabetes & Metabolism Journal.2025; 49(6): 1178. CrossRef
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The Korean Journal of Internal Medicine.2025; 40(6): 1017. CrossRef
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Scientific Reports.2025;[Epub] CrossRef
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Scientific Reports.2025;[Epub] CrossRef
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Journal of Obesity & Metabolic Syndrome.2025; 34(4): 414. CrossRef
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Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
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Endocrinology and Metabolism.2025; 40(6): 991. CrossRef
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Diabetes, Obesity and Metabolism.2024; 26(2): 567. CrossRef
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American Journal of Preventive Medicine.2024; 66(4): 717. CrossRef
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Public Health.2024; 226: 173. CrossRef
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Yonsei Medical Journal.2024; 65(1): 42. CrossRef
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Yeong Jun Ju, Woorim Kim, Kyujin Chang, Tae Hoon Lee, Soon Young Lee
Preventive Medicine.2024; 178: 107793. CrossRef
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Tae Kyung Yoo, Kyung‐Do Han, Eun‐Jung Rhee, Won‐Young Lee
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BMC Gastroenterology.2024;[Epub] CrossRef
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Diabetes Therapy.2024; 15(2): 547. CrossRef
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Weiwei Dong, Xiaobai Liu, Lu Ma, Zhiyong Yang, Chunyan Ma
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Diabetes Research and Clinical Practice.2024; 208: 111109. CrossRef
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Cardiovascular Prevention and Pharmacotherapy.2024; 6(1): 17. CrossRef
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Kidney Research and Clinical Practice.2024; 43(1): 20. CrossRef
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Cardiovascular Prevention and Pharmacotherapy.2024; 6(1): 33. CrossRef
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BMJ.2024; 384: e076388. CrossRef
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Hee Joo Yang, Mi Young Lee, Jeong Hyeon Lee, Chang Jin Jung, Woo Jin Lee, Chong Hyun Won, Mi Woo Lee, Joon Min Jung, Sung Eun Chang
Scientific Reports.2024;[Epub] CrossRef
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BMJ Open Diabetes Research & Care.2024; 12(1): e003696. CrossRef
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Na Yeon Kim, Haekyung Lee, Sehee Kim, Ye-Jee Kim, Hyunsuk Lee, Junhyeong Lee, Soo Heon Kwak, Seunggeun Lee
Scientific Reports.2024;[Epub] CrossRef
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Cancer Medicine.2024;[Epub] CrossRef
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Diabetes & Metabolism Journal.2024; 48(2): 279. CrossRef
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Min Jin Lee, Ji Hyun Bae, Ah Reum Khang, Dongwon Yi, Mi Sook Yun, Yang Ho Kang
Diabetes Research and Clinical Practice.2024; 210: 111640. CrossRef
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Advances in Therapy.2024; 41(5): 1967. CrossRef
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Respirology.2024; 29(7): 624. CrossRef
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Nutrition Research and Practice.2024; 18(2): 239. CrossRef
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The Journal of Korean Diabetes.2024; 25(1): 4. CrossRef
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Diabetes, Obesity and Metabolism.2024; 26(9): 3642. CrossRef
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Scandinavian Journal of Clinical and Laboratory Investigation.2024; 84(3): 168. CrossRef
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Journal of Clinical Medicine.2024; 13(8): 2311. CrossRef
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Diabetes, Obesity and Metabolism.2024; 26(7): 2567. CrossRef
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Endocrinology and Metabolism.2024; 39(2): 344. CrossRef
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Epidemiology and Health.2024; 46: e2024029. CrossRef
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Endocrinology and Metabolism.2024; 39(3): 479. CrossRef
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Min Seok Kim, Sang Jun Park, Kwangsic Joo, Se Joon Woo
Journal of Korean Medical Science.2024;[Epub] CrossRef
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Doeon Gu, Jinyeong Lim, Kyung Yeon Han, In-Ho Seo, Jae Hwan Jee, Soo Jin Cho, Yoon Ho Choi, Sung Chul Choi, Jang Hyun Koh, Jin-Young Lee, Mira Kang, Dong-Hyuk Jung, Woong-Yang Park
Frontiers in Endocrinology.2024;[Epub] CrossRef
Diabetes and Heart Failure: A Literature Review, Reflection and Outlook
Xiya Li, Xiaoyang Zhou, Ling Gao
Biomedicines.2024; 12(7): 1572. CrossRef
Korean National Burden of Disease: The Importance of Diabetes Management
Chung-Nyun Kim, Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
Diabetes & Metabolism Journal.2024; 48(4): 518. CrossRef
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Yu-Na Kim, Sung Won Lee, Sangwook Park
Biomedical Science Letters.2024; 30(2): 65. CrossRef
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Mi-Joon Lee, Bum-Jeun Seo, Yeon-Sook Kim
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Eun‐Jung Shim, Sang Jin Park, Gyu Hyeong Im, Ruth A. Hackett, Paola Zaninotto, Andrew Steptoe
British Journal of Health Psychology.2024; 29(4): 1000. CrossRef
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Jae Hyun Bae, Eun Hee Park, Hae Kyung Lee, Kun Ho Yoon, Kyu Chang Won, Hyun Mi Kim, Sin Gon Kim
Diabetes & Metabolism Journal.2024; 48(4): 790. CrossRef
Transcriptional regulation of multi-tissue mRNA expression by L-arabinose mitigates metabolic disorders in leptin receptor-deficient mice
Youngji Han, Yuri Jeong, Jin Hyup Lee, Seung Pil Pack
Food Bioscience.2024; 61: 104881. CrossRef
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association
Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang
Diabetes & Metabolism Journal.2024; 48(4): 546. CrossRef
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Heung Yong Jin, Tae Sun Park
Diabetes & Metabolism Journal.2024; 48(4): 709. CrossRef
Holistic and Personalized Strategies for Managing in Elderly Type 2 Diabetes Patients
Jae-Seung Yun, Kyuho Kim, Yu-Bae Ahn, Kyungdo Han, Seung-Hyun Ko
Diabetes & Metabolism Journal.2024; 48(4): 531. CrossRef
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Wonil Park, Dongjun Lee
Healthcare.2024; 12(16): 1644. CrossRef
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Wonwoo Jang, Seokjun Kim, Yejun Son, Soeun Kim, Hyeon Jin Kim, Hyesu Jo, Jaeyu Park, Kyeongmin Lee, Hayeon Lee, Mark A Tully, Masoud Rahmati, Lee Smith, Jiseung Kang, Selin Woo, Sunyoung Kim, Jiyoung Hwang, Sang Youl Rhee, Dong Keon Yon
JMIR Public Health and Surveillance.2024; 10: e59571. CrossRef
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Shinae Kang, Yu-Bae Ahn, Tae Keun Oh, Won-Young Lee, Sung Wan Chun, Boram Bae, Amine Dahaoui, Jin Sook Jeong, Sungeun Jung, Hak Chul Jang
Diabetes & Metabolism Journal.2024; 48(5): 929. CrossRef
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Heashoon Lee
Journal of Korean Gerontological Nursing.2024; 26(3): 257. CrossRef
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Hun Jee Choe, Yeh-Hee Ko, Sun Joon Moon, Chang Ho Ahn, Kyoung Hwa Ha, Hyeongsuk Lee, Jae Hyun Bae, Hyung Joon Joo, Hyejin Lee, Jang Wook Son, Dae Jung Kim, Sin Gon Kim, Kwangsoo Kim, Young Min Cho
Endocrinology and Metabolism.2024; 39(4): 622. CrossRef
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Khongorzul Dashdondov, Suehyun Lee, Munkh-Uchral Erdenebat
Applied Sciences.2024; 14(17): 7480. CrossRef
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Hae Young Lee, Seung-Hyun Ko, Sungjoon Park, Kyuho Kim, Song-Yi Kim, In-Jeong Cho, Eun Joo Cho, Hyeon Chang Kim, Jae-Hyeong Park, Sung Kee Ryu, Min Kyong Moon, Sang-Hyun Ihm
Clinical Hypertension.2024;[Epub] CrossRef
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In‐Kyung Jeong, Kyung Mook Choi, Kyung Ah Han, Kyoung‐Ah Kim, In Joo Kim, Seung Jin Han, Won Young Lee, Soon Jib Yoo
Diabetes, Obesity and Metabolism.2024; 26(11): 5065. CrossRef
The association between health literacy and screening for disease-specific complications among community-dwelling adults with diabetes
Fatima Nari, Jae Kwan Jun, Kyoung Hee Oh, Wonjeong Jeong
Frontiers in Public Health.2024;[Epub] CrossRef
Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial
Ji Hye Heo, Kyung Ah Han, Jun Hwa Hong, Hyun-Ae Seo, Eun-Gyoung Hong, Jae Myung Yu, Hye Seung Jung, Bong-Soo Cha
Diabetes & Metabolism Journal.2024; 48(5): 937. CrossRef
Efficacy and Safety of Alogliptin-Pioglitazone Combination for Type 2 Diabetes Mellitus Poorly Controlled with Metformin: A Multicenter, Double-Blind Randomized Trial
Ji-Yeon Park, Joonyub Lee, Yoon-Hee Choi, Kyung Wan Min, Kyung Ah Han, Kyu Jeung Ahn, Soo Lim, Young-Hyun Kim, Chul Woo Ahn, Kyung Mook Choi, Kun-Ho Yoon
Diabetes & Metabolism Journal.2024; 48(5): 915. CrossRef
Adherence to the nutritional recommendations according to diabetes status in Korean adults: a cross-sectional study
Jong Han Choi, Chen Lulu, Seon-Joo Park, Hae-Jeung Lee
BMC Public Health.2024;[Epub] CrossRef
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Hye Ran Shin, Jihye Kim, SuJin Song
Nutrition Journal.2024;[Epub] CrossRef
Prediabetes persistence or remission and subsequent risk of gallbladder cancer: A nationwide cohort study
Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Young Suk Park, Joon Oh Park, Ho Yeong Lim, Jay J. Shen
European Journal of Cancer.2024; 213: 114312. CrossRef
National trends in type 2 diabetes mellitus stratified by central adiposity using waist-to-height ratio in South Korea, 2005–2022
Hyunjee Kim, Seoyoung Park, Jaeyu Park, Yejun Son, Soeun Kim, Yesol Yim, Hyesu Jo, Kyeongmin Lee, Yi Deun Jeong, Jiyeon Oh, Hanseul Cho, Damiano Pizzol, Jiyoung Hwang, Lee Smith, Dong Keon Yon
Scientific Reports.2024;[Epub] CrossRef
Association of Monocyte Chemoattractant Protein-1 (MCP-1) 2518 A/G Polymorphism with Obesity in Korean Type 2 Diabetes Mellitus
Sangshin Park, Dong-Hwa Lee, Shinyoung Lee, Hyun Jeong Jeon
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3917. CrossRef
Association between the duration of oral contraceptive use and the prevalence of type 2 diabetes mellitus: Korea National Health and Nutrition Examination Survey (KNHANES) 2007–2021
Mikyung Ryu
Korean Journal of Health Education and Promotion.2024; 41(3): 73. CrossRef
Insulin Resistance and Impaired Insulin Secretion Predict Incident Diabetes: A Statistical Matching Application to the Two Korean Nationwide, Population-Representative Cohorts
Hyemin Jo, Soyeon Ahn, Jung Hun Ohn, Cheol Min Shin, Eunjeong Ji, Donggil Kim, Sung Jae Jung, Joongyub Lee
Endocrinology and Metabolism.2024; 39(5): 711. CrossRef
Association of aerobic and muscle-strengthening physical activity with chronic kidney disease in participants with hypertension
Yunmin Han, Younghwan Choi, Yeon Soo Kim
Clinical Hypertension.2024;[Epub] CrossRef
Association of relative handgrip strength on the development of diabetes mellitus in elderly Koreans
Yeo Ju Sohn, Hong Soo Lee, Hasuk Bae, Hee Cheol Kang, Hyejin Chun, Insun Ryou, Eun Jee Chang, Sungchan Kang, Sang Wha Lee, Kyung Won Shim, Mario Ulises Pérez-Zepeda
PLOS ONE.2024; 19(10): e0309558. CrossRef
Paradigm shift from glucocentric to organ protection for the management of hyperglycemia in patients with type 2 diabetes
Jie-Eun Lee, Jong Chul Won
Cardiovascular Prevention and Pharmacotherapy.2024; 6(4): 116. CrossRef
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종한 최, 민경 문
Public Health Weekly Report.2024; 17(44): 1905. CrossRef
Socioeconomic inequalities in the prevalence, non-awareness, non-treatment, and non-control of diabetes among South Korean adults in 2021
Seongju Kim, Dong Jun Kim, Hooyeon Lee, Dong Keon Yon
PLOS ONE.2024; 19(11): e0313988. CrossRef
Association between alcohol consumption and risk of developing tuberculosis in patients with diabetes: a nationwide retrospective cohort study
Chiwook Chung, Kyu Na Lee, Kyungdo Han, Junhee Park, Dong Wook Shin, Sei Won Lee
Respiratory Research.2024;[Epub] CrossRef
Diagnosis and treatment of gestational diabetes mellitus
Hyun Sun Ko, Yoon-Hee Choi
Journal of the Korean Medical Association.2024; 67(11): 686. CrossRef
Cardiovascular Disease & Diabetes Statistics in Korea: Nationwide Data 2010 to 2019
Jin Hwa Kim, Junyeop Lee, Kyungdo Han, Jae-Taek Kim, Hyuk-Sang Kwon
Diabetes & Metabolism Journal.2024; 48(6): 1084. CrossRef
Long‐Term Effects of an Automated Personalized Self‐Care Program for Patients With Type 2 Diabetes
Haejung Lee, Gaeun Park, DaeEun Lee, Ah Reum Khang, Min Jin Lee
Nursing & Health Sciences.2024;[Epub] CrossRef
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Su Hwan Park, Ji Hyoung Chey, Jun Heo, Kwang Eon Han, Sung Who Park, Iksoo Byon, Han Jo Kwon, Ogugua Ndubuisi Okonkwo
PLOS ONE.2024; 19(12): e0306091. CrossRef
Implications of prognostic nutritional index in predicting adverse outcomes of uncontrolled diabetic patients: a cohort study of the national health and nutrition examination survey from 2005 – 2018
Fei Liu, Zhili Jiang, Wei Luo, Yunxiao Yang, Shuai Guo, Jiayi Yi, Geng Shen, Wei Li, Lin Wang, Xiuhuan Chen, Zhaogong Zhi, Tian Liu, Xuedong Zhao, Chen Li, Hai Gao
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Lean diabetes: 20-year trends in its prevalence and clinical features among Korean adults
Ji Min Kim, Kyoung Hye Joung, Hyun Jin Kim, Bon Jeong Ku, Sukyoung Jung, Ju Hee Lee
BMC Public Health.2024;[Epub] CrossRef
Adherence to ADA Clinical Guidelines in Type 2 Diabetes Management in Public Health Clinics in Palestine
Abdallah Abukhalil, Sana Muhanna, Misk Madi, Ni'meh Al-Shami, Hani Naseef, Abdullah Rabba
Patient Preference and Adherence.2024; Volume 18: 2667. CrossRef
Risk of Pancreatic Cancer and Use of Dipeptidyl Peptidase 4 Inhibitors in Patients with Type 2 Diabetes: A Propensity Score-Matching Analysis
Mee Kyoung Kim, Kyungdo Han, Hyuk-Sang Kwon, Soon Jib Yoo
Endocrinology and Metabolism.2023; 38(4): 426. CrossRef
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Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
The Korean Journal of Internal Medicine.2023; 38(1): 93. CrossRef
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Dararat Eksombatchai, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Hongjo Choi, Young Ae Kang
International Journal of Infectious Diseases.2023; 127: 1. CrossRef
Response to Letter to the Editor From Han and Xu: “Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes”
Dae Ho Lee
The Journal of Clinical Endocrinology & Metabolism.2023; 108(4): e58. CrossRef
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Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
Journal of Lipid and Atherosclerosis.2023; 12(1): 12. CrossRef
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Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
International Journal of Heart Failure.2023; 5(1): 1. CrossRef
Lipid Management in Korean People with Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
Ye Seul Yang, Hack-Lyoung Kim, Sang-Hyun Kim, Min Kyong Moon
Diabetes & Metabolism Journal.2023; 47(1): 1. CrossRef
Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Diabetes & Metabolism Journal.2023; 47(1): 10. CrossRef
Risk of type 2 diabetes mellitus in catholic priests compared with general public
Youngmi Eun, Sun Myeong Ock, Se-Hong Kim, Ju Hye Chung, Se Jin Park, Churlmin Kim, Min-Kyun Im, Kyung-do Han
Acta Diabetologica.2023; 60(5): 655. CrossRef
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Anan S Jarab, Walid Al-Qerem, Salam Alqudah, Shrouq R Abu Heshmeh, Tareq L Mukattash, Karem H Alzoubi
Electronic Journal of General Medicine.2023; 20(3): em477. CrossRef
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Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Jeong Mi Seo, Hongjo Choi, Young Ae Kang
BMJ Open.2023; 13(3): e069642. CrossRef
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Miran Jin, Jayeun Kim, Kyuhyun Yoon
Korean Journal of Community Nutrition.2023; 28(1): 38. CrossRef
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Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
Diabetes & Metabolism Journal.2023; 47(2): 211. CrossRef
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Jong Ha Baek, Yong-Moon Park, Kyung Do Han, Min Kyong Moon, Jong Han Choi, Seung-Hyun Ko
Diabetes & Metabolism Journal.2023; 47(2): 201. CrossRef
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Heeyoung Kim, Choon Ok Kim, Hyeonsoo Park, Min Soo Park, Dasohm Kim, Taegon Hong, Yesong Shin, Byung Hak Jin
Translational and Clinical Pharmacology.2023; 31(1): 59. CrossRef
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Seon Mee Kang, Han Mi Yun, Minji Sohn, Soo Lim
Diabetes, Obesity and Metabolism.2023; 25(7): 1922. CrossRef
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Jungah Lim
The Journal of Korean Diabetes.2023; 24(1): 29. CrossRef
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Jun Sung Moon
The Journal of Korean Diabetes.2023; 24(1): 1. CrossRef
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Jin ha Jang, Wonjin Kim, Jin Sil Moon, Eun Roh, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm, Ji Hye Huh
Journal of Clinical Medicine.2023; 12(8): 2899. CrossRef
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Yohwan Lim, Hye Jun Kim, Sung Soo Yoon, Sang Jun Lee, Myeong Hoon Lee, Hyewon Park, Sun Jae Park, Seogsong Jeong, Hyun Wook Han
Journal of Korean Medical Science.2023;[Epub] CrossRef
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Jiyoung Park, Sea-Kwan Oh, Miae Doo, Hyun-Jung Chung, Hyun-Jin Park, Hyejin Chun
Nutrients.2023; 15(10): 2248. CrossRef
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Joonyub Lee, Jin Yu, Kun-Ho Yoon
Diabetes & Metabolism Journal.2023; 47(3): 307. CrossRef
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Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park
Diabetes & Metabolism Journal.2023; 47(3): 347. CrossRef
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Yeong Geun Gwon, Seung Jin Han, Kyoung Hoon Kim
Journal of Preventive Medicine and Public Health.2023; 56(3): 248. CrossRef
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Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Nutrients.2023; 15(12): 2786. CrossRef
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Dae Joong Ma, Heesun Lee, Ji Min Choi, Hyo Eun Park, Su-Yeon Choi, Hyuk Jin Choi
Frontiers in Cardiovascular Medicine.2023;[Epub] CrossRef
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You Lee Yang, Eun-Ok Im, Yunmi Kim
BMC Nursing.2023;[Epub] CrossRef
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Kyoung Hwa Ha, Dae Jung Kim, Seung Jin Han
Diabetes Research and Clinical Practice.2023; 203: 110820. CrossRef
Paradigm Shift in Management of Hyperglycemia in Patients with Type 2 Diabetes: Glucocentric versus Organ Protection
Jong Chul Won
The Journal of Korean Diabetes.2023; 24(2): 59. CrossRef
Medical nutrition therapy for diabetes mellitus
Suk Chon
Journal of the Korean Medical Association.2023; 66(7): 421. CrossRef
Prevalence and treatment status of diabetes mellitus in Korea
Hyuk-Sang Kwon
Journal of the Korean Medical Association.2023; 66(7): 404. CrossRef
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Kyuho Kim, Bongseong Kim, Hyunho Kim, Hyung Soon Park, Yu-Bae Ahn, Seung-Hyun Ko, Kyungdo Han, Jae-Seung Yun
Diabetes Research and Clinical Practice.2023; 203: 110866. CrossRef
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Sunyoung Kim, Sang Youl Rhee
Diabetes Research and Clinical Practice.2023; 203: 110864. CrossRef
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Youn Huh, Jung Eun Yoo, Sang‐Hyun Park, Kyungdo Han, Seon Mee Kim, Hye Soon Park, Kyung Hwan Cho, Jin‐Soo Ahn, Sang Ho Jun, Ga Eun Nam
Journal of the American Heart Association.2023;[Epub] CrossRef
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Salma Nabila, Jaesung Choi, Ji-Eun Kim, Seokyung Hahn, In-Kyung Hwang, Tae-Il Kim, Hee-Kyung Park, Ji-Yeob Choi
Scientific Reports.2023;[Epub] CrossRef
Long-term Effectiveness of the National Diabetes Quality Assessment Program in South Korea
Ji Hye Huh, Serim Kwon, Gui Ok Kim, Bo Yeon Kim, Kyoung Hwa Ha, Dae Jung Kim
Diabetes Care.2023; 46(9): 1700. CrossRef
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Byung-Mo Oh
Annals of Rehabilitation Medicine.2023; 47(4): 234. CrossRef
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Yu-Gyeong Kim, Ha-Neul Choi, Jung-Eun Yim
Journal of Nutrition and Health.2023; 56(4): 377. CrossRef
2023 Clinical Practice Guidelines for Diabetes Mellitus of the Korean Diabetes Association
Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Nan Hee Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, YoonJu Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae J
Diabetes & Metabolism Journal.2023; 47(5): 575. CrossRef
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Seung-Hyun Ko, Kyung Do Han, Yong-Moon Park, Jae-Seung Yun, Kyuho Kim, Jae-Hyun Bae, Hyuk-Sang Kwon, Nan-Hee Kim
Diabetes & Metabolism Journal.2023; 47(5): 643. CrossRef
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Kyung Ae Lee
The Journal of Korean Diabetes.2023; 24(3): 111. CrossRef
Association between initial continuity of care status and diabetes-related health outcomes in older patients with type 2 diabetes mellitus: A nationwide retrospective cohort study in South Korea
Hyun Woo Jung, Woo-Ri Lee
Primary Care Diabetes.2023; 17(6): 600. CrossRef
2023 Clinical Practice Guidelines for Diabetes
Min Kyong Moon
The Journal of Korean Diabetes.2023; 24(3): 120. CrossRef
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Huiyul Park, Eileen L. Yoon, Mimi Kim, Jonghyun Lee, Hye-Lin Kim, Seon Cho, Eun-Hee Nah, Dae Won Jun
Hepatology Communications.2023;[Epub] CrossRef
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Joonyub Lee, Hun-Sung Kim, Kee-Ho Song, Soon Jib Yoo, Kyungdo Han, Seung-Hwan Lee
Endocrinology and Metabolism.2023; 38(5): 525. CrossRef
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Sunghwan Suh
Endocrinology and Metabolism.2023; 38(5): 522. CrossRef
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Yeongkeun Kwon, Jin-Won Kwon, Jiyun Kim, Dohyang Kim, Jinseub Hwang, Jane Ha, Shin-Hoo Park, Sungsoo Park
Journal of the American College of Surgeons.2023; 237(6): 902. CrossRef
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Diabetes & Metabolism Journal.2023; 47(6): 808. CrossRef
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Se Hyun Kwak, Dawoon Jeong, Jeongha Mok, Doosoo Jeon, Hee-Yeon Kang, Hee Jin Kim, Hee-Sun Kim, Hongjo Choi, Young Ae Kang, Frederick Quinn
PLOS ONE.2023; 18(12): e0295556. CrossRef
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Mi Kyung Kim, Hye Soon Kim
Journal of Metabolic and Bariatric Surgery.2023; 12(2): 26. CrossRef
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The Journal of Korean Diabetes.2023; 24(4): 173. CrossRef
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Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, Sang-Man Jin, Jae Hyeon Kim
Cardiovascular Diabetology.2022;[Epub] CrossRef
Severe hypoglycemia as a risk factor for cardiovascular outcomes in patients with type 2 diabetes: is it preventable?
Seung-Hyun Ko
Cardiovascular Prevention and Pharmacotherapy.2022; 4(3): 106. CrossRef
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Diabetes & Metabolism Journal.2022; 46(4): 552. CrossRef
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Journal of the Korean Medical Association.2022; 65(7): 388. CrossRef
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Public Health Weekly Report.2022; 15(35): 2474. CrossRef
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Yoonjin Park, Su Jung Lee
International Journal of Environmental Research and Public Health.2022; 19(18): 11832. CrossRef
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Nami Lee, Dae Jung Kim
Journal of Korean Medical Science.2022;[Epub] CrossRef
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Diabetes & Metabolism Journal.2022; 46(5): 667. CrossRef
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Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
The Journal of Clinical Endocrinology & Metabolism.2022; 107(11): 3022. CrossRef
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Gi Yeon Lee
The Journal of Korean Diabetes.2022; 23(3): 201. CrossRef
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Journal of the Korean Medical Association.2022; 65(10): 640. CrossRef
Screening for Prediabetes and Diabetes in Korean Nonpregnant Adults: A Position Statement of the Korean Diabetes Association, 2022
Kyung Ae Lee, Dae Jung Kim, Kyungdo Han, Suk Chon, Min Kyong Moon
Diabetes & Metabolism Journal.2022; 46(6): 819. CrossRef
Oldies but Goodies: Thiazolidinedione as an Insulin Sensitizer with Cardioprotection
Eun-Hee Cho
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The Mediating Effect of Acceptance Action in the Relationship between Diabetes Distress and Self-stigma among Old Adults with Diabetes in South Korea
Hyesun Kim, Kawoun Seo
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Effects of Sodium-Glucose Cotransporter-2 Inhibitors and Thiazolidinedione on New-Onset Atrial Fibrillation Risk to Patients with Type 2 Diabetes
Haegeun Song, Yoo Ri Kim, Seung Eun Lee, Hyewon Nam, Hoseob Kim, Dae-Sung Kyoung, Kyoung-Ah Kim
Reviews in Cardiovascular Medicine.2022;[Epub] CrossRef

Response

Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study (Diabetes Metab J 2021;45:368-78): Kyoung Jin Kim, Jimi Choi, Jae Hyun Bae, Kyeong Jin Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim, Nam Hoon Kim; Diabetes Metab J. 2021;45(4):617-618. Published online July 30, 2021; DOI: https://doi.org/10.4093/dmj.2021.0152

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CIN: Computers, Informatics, Nursing.2024; 42(9): 665. CrossRef
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Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef

Original Articles

Drug/Regimen
Efficacy and Safety of Self-Titration Algorithms of Insulin Glargine 300 units/mL in Individuals with Uncontrolled Type 2 Diabetes Mellitus (The Korean TITRATION Study): A Randomized Controlled Trial: Jae Hyun Bae, Chang Ho Ahn, Ye Seul Yang, Sun Joon Moon, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho; Diabetes Metab J. 2022;46(1):71-80. Published online June 16, 2021; DOI: https://doi.org/10.4093/dmj.2020.0274

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Background
To compare the efficacy and safety of two insulin self-titration algorithms, Implementing New Strategies with Insulin Glargine for Hyperglycemia Treatment (INSIGHT) and EDITION, for insulin glargine 300 units/mL (Gla-300) in Korean individuals with uncontrolled type 2 diabetes mellitus (T2DM).
Methods
In a 12-week, randomized, open-label trial, individuals with uncontrolled T2DM requiring basal insulin were randomized to either the INSIGHT (adjusted by 1 unit/day) or EDITION (adjusted by 3 units/week) algorithm to achieve a fasting self-monitoring of blood glucose (SMBG) in the range of 4.4 to 5.6 mmol/L. The primary outcome was the proportion of individuals achieving a fasting SMBG ≤5.6 mmol/L without noct urnal hypoglycemia at week 12.
Results
Of 129 individuals (age, 64.1±9.5 years; 66 [51.2%] women), 65 and 64 were randomized to the INSIGHT and EDITION algorithms, respectively. The primary outcome of achievement was comparable between the two groups (24.6% vs. 23.4%, P=0.876). Compared with the EDITION group, the INSIGHT group had a greater reduction in 7-point SMBG but a similar decrease in fasting plasma glucose and glycosylated hemoglobin. The increment of total daily insulin dose was significantly higher in the INSIGHT group than in the EDITION group (between-group difference: 5.8±2.7 units/day, P=0.033). However, body weight was significantly increased only in the EDITION group (0.6±2.4 kg, P=0.038). There was no difference in the occurrence of hypoglycemia between the two groups. Patient satisfaction was significantly increased in the INSIGHT group (P=0.014).
Conclusion
The self-titration of Gla-300 using the INSIGHT algorithm was effective and safe compared with that using the EDITION algorithm in Korean individuals with uncontrolled T2DM (ClinicalTrials.gov number: NCT03406663).

Citations

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Comparison of Insulin Titration Strategies for Glycemic Control in Type 2 Diabetes: A Systematic Review and Network Meta-analysis
Kansak Boonpattharatthiti, Kirana Wechkunanukul, Noramon Mayang, E Lyn Lee, Anjana Fuangchan, Alice Y.Y. Cheng, Nathorn Chaiyakunapruk, Teerapon Dhippayom
Diabetes Care.2025; 48(5): 837. CrossRef
Time for Using Machine Learning for Dose Guidance in Titration of People With Type 2 Diabetes? A Systematic Review of Basal Insulin Dose Guidance
Camilla Heisel Nyholm Thomsen, Stine Hangaard, Thomas Kronborg, Peter Vestergaard, Ole Hejlesen, Morten Hasselstrøm Jensen
Journal of Diabetes Science and Technology.2024; 18(5): 1185. CrossRef
Comparative efficacy and safety of weekly tirzepatide versus weekly insulin in type 2 diabetes: A network meta‐analysis of randomized clinical trials
Hazem Ayesh, Sajida Suhail, Suhail Ayesh, Kevin Niswender
Diabetes, Obesity and Metabolism.2024; 26(9): 3801. CrossRef
Basal insulin titration algorithms in patients with type 2 diabetes: the simplest is the best (?)
V.I. Katerenchuk
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(1): 72. CrossRef
Issues of insulin therapy for type 2 diabetes and ways to solve them
V.I. Katerenchuk, A.V. Katerenchuk
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2023; 19(3): 240. CrossRef

COVID-19
Use of Renin-Angiotensin-Aldosterone System Inhibitors and Severe COVID-19 Outcomes in Patients with Hypertension: A Nationwide Cohort Study: Jae Hyun Bae, Sun Kyu Choi, Nam Hoon Kim, Juneyoung Lee, Sin Gon Kim; Diabetes Metab J. 2021;45(3):430-438. Published online February 22, 2021; DOI: https://doi.org/10.4093/dmj.2020.0279

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Background
Angiotensin-converting enzyme 2 facilitates the entry of severe acute respiratory syndrome coronavirus 2 into the human body. We investigated the association of renin-angiotensin-aldosterone system (RAAS) inhibitor use with severe coronavirus disease 2019 (COVID-19) outcomes in hypertensive patients.
Methods
We identified hypertensive patients with confirmed COVID-19 from the Korean Health Insurance Review and Assessment Service from inception to May 15, 2020. The primary outcome was the composite of intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), continuous renal replacement therapy (CRRT), extracorporeal membrane oxygenation (ECMO), and death from COVID-19. The individual components were evaluated as secondary outcomes.
Results
Of 1,374 hypertensive patients with COVID-19, 1,076 (78.3%) and 298 (21.7%) were users and never-users of RAAS inhibitors, respectively. The RAAS inhibitor users were not associated with the risk of the primary outcome (adjusted odds ratio [aOR], 0.72; 95% confidence interval [CI], 0.46 to 1.10). The risk of ICU admission was significantly lower in the users than the never-users (aOR, 0.44; 95% CI, 0.24 to 0.84). The RAAS inhibitors were beneficial only in ICU admissions that did not require IMV (aOR, 0.28; 95% CI, 0.14 to 0.58). The risk of death from COVID-19 was comparable between the groups (aOR, 1.09; 95% CI, 0.64 to 1.85). We could not evaluate the risks of CRRT and ECMO owing to the small number of events.
Conclusion
RAAS inhibitor use was not associated with the composite of severe outcomes in the hypertensive patients with COVID-19 but significantly lowered the risk of ICU admission, particularly in patients who did not require IMV.

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Medicine.2022; 101(48): e31988. CrossRef

Complications
Time to Reach Target Glycosylated Hemoglobin Is Associated with Long-Term Durable Glycemic Control and Risk of Diabetic Complications in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A 6-Year Observational Study: Kyoung Jin Kim, Jimi Choi, Jae Hyun Bae, Kyeong Jin Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim, Nam Hoon Kim; Diabetes Metab J. 2021;45(3):368-378. Published online October 20, 2020; DOI: https://doi.org/10.4093/dmj.2020.0046

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Background
To evaluate the association of time to reach the target glycosylated hemoglobin (HbA1c) level with long-term durable glycemic control and risk of diabetic complications in patients with newly diagnosed type 2 diabetes mellitus (T2DM).
Methods
In a longitudinal observational cohort, 194 patients with T2DM newly diagnosed between January 2011 and March 2013 were followed up over 6 years. Patients were classified according to the time needed to reach the target HbA1c (<7.0%): <3, 3 to 6 (early achievement group), and ≥6 months (late achievement group). Risks of microvascular complications including diabetic retinopathy, nephropathy, and neuropathy as well as macrovascular events including ischemic heart disease, ischemic stroke, and peripheral arterial disease were assessed by multivariable Cox proportional hazards analysis.
Results
During a median follow-up of 6.53 years, 66 microvascular and 14 macrovascular events occurred. Maintenance of durable glycemic control over 6 years was more likely in the early achievement groups than in the late achievement group (34.5%, 30.0%, and 16.1% in <3, 3 to 6, and ≥6 months, respectively, P=0.039). Early target HbA1c achievement was associated with lower risk of composite diabetic complications (adjusted hazard ratio [HR, 0.47; 95% confidence interval [CI], 0.26 to 0.86 in <3 months group) (adjusted HR, 0.50; 95% CI, 0.23 to 1.10 in 3 to 6 months group, in reference to ≥6 months group). Similar trends were maintained for risks of microvascular and macrovascular complications, although statistical significance was not reached for macrovascular complications.
Conclusion
Early target HbA1c achievement was associated with long-term durable glycemic control and reduced risk of diabetic complications in newly diagnosed T2DM.

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Response

Response: Premeal Consumption of a Protein-Enriched, Dietary Fiber-Fortified Bar Decreases Total Energy Intake in Healthy Individuals (Diabetes Metab J 2019;43:879–92): Chang Ho Ahn, Jae Hyun Bae, Young Min Cho; Diabetes Metab J. 2020;44(1):207-208. Published online February 21, 2020; DOI: https://doi.org/10.4093/dmj.2020.0026; [Original]

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Original Articles

Cardiovascular Risk/Epidemiology
Validation of Risk Prediction Models for Atherosclerotic Cardiovascular Disease in a Prospective Korean Community-Based Cohort: Jae Hyun Bae, Min Kyong Moon, Sohee Oh, Bo Kyung Koo, Nam Han Cho, Moon-Kyu Lee; Diabetes Metab J. 2020;44(3):458-469. Published online January 13, 2020; DOI: https://doi.org/10.4093/dmj.2019.0061

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Abstract PDF Supplementary Material PubReader ePub

Background

To investigate the performance of the 2013 American College of Cardiology/American Heart Association Pooled Cohort Equations (PCE) in a large, prospective, community-based cohort in Korea and to compare it with that of the Framingham Global Cardiovascular Disease Risk Score (FRS-CVD) and the Korean Risk Prediction Model (KRPM).

Methods

In the Korean Genome and Epidemiology Study (KOGES)-Ansan and Ansung study, we evaluated calibration and discrimination of the PCE for non-Hispanic whites (PCE-WH) and for African Americans (PCE-AA) and compared their predictive abilities with the FRS-CVD and the KRPM.

Results

The present study included 7,932 individuals (3,778 men and 4,154 women). The PCE-WH and PCE-AA moderately overestimated the risk of atherosclerotic cardiovascular disease (ASCVD) for men (6% and 13%, respectively) but underestimated the risk for women (−49% and −25%, respectively). The FRS-CVD overestimated ASCVD risk for men (91%) but provided a good risk prediction for women (3%). The KRPM underestimated ASCVD risk for men (−31%) and women (−31%). All the risk prediction models showed good discrimination in both men (C-statistic 0.730 to 0.735) and women (C-statistic 0.726 to 0.732). Recalibration of the PCE using data from the KOGES-Ansan and Ansung study substantially improved the predictive accuracy in men.

Conclusion

In the KOGES-Ansan and Ansung study, the PCE overestimated ASCVD risk for men and underestimated the risk for women. The PCE-WH and the FRS-CVD provided an accurate prediction of ASCVD in men and women, respectively.

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Drug/Regimen
Glucagon-Like Peptide-1 Receptor Agonist Differentially Affects Brain Activation in Response to Visual Food Cues in Lean and Obese Individuals with Type 2 Diabetes Mellitus: Jae Hyun Bae, Hyung Jin Choi, Kang Ik Kevin Cho, Lee Kyung Kim, Jun Soo Kwon, Young Min Cho; Diabetes Metab J. 2020;44(2):248-259. Published online November 4, 2019; DOI: https://doi.org/10.4093/dmj.2019.0018

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298 Download
25 Web of Science
28 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

To investigate the effects of a glucagon-like peptide-1 receptor agonist on functional brain activation in lean and obese individuals with type 2 diabetes mellitus (T2DM) in response to visual food cues.

Methods

In a randomized, single-blinded, crossover study, 15 lean and 14 obese individuals with T2DM were administered lixisenatide or normal saline subcutaneously with a 1-week washout period. We evaluated brain activation in response to pictures of high-calorie food, low-calorie food, and nonfood using functional magnetic resonance imaging and measured appetite and caloric intake in participants who were given access to an ad libitum buffet.

Results

Obese individuals with T2DM showed significantly greater activation of the hypothalamus, pineal gland, parietal cortex (high-calorie food vs. low-calorie food, P<0.05), orbitofrontal cortex (high-calorie food vs. nonfood, P<0.05), and visual cortex (food vs. nonfood, P<0.05) than lean individuals with T2DM. Lixisenatide injection significantly reduced the functional activation of the fusiform gyrus and lateral ventricle in obese individuals with T2DM compared with that in lean individuals with T2DM (nonfood vs. high-calorie food, P<0.05). In addition, in individuals who decreased their caloric intake after lixisenatide injection, there were significant interaction effects between group and treatment in the posterior cingulate, medial frontal cortex (high-calorie food vs. low-calorie food, P<0.05), hypothalamus, orbitofrontal cortex, and temporal lobe (food vs. nonfood, P<0.05).

Conclusion

Brain responses to visual food cues were different in lean and obese individuals with T2DM. In addition, acute administration of lixisenatide differentially affected functional brain activation in these individuals, especially in those who decreased their caloric intake after lixisenatide injection.

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Acta Biomedica Scientifica.2026; 11(3): 162. CrossRef
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Diabetes Research and Clinical Practice.2025; 224: 112175. CrossRef
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Diabetes & Metabolism Journal.2025; 49(4): 893. CrossRef
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International Journal of Molecular Sciences.2025; 27(1): 266. CrossRef
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Acta Diabetologica.2023; 60(8): 1099. CrossRef
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Journal of Diabetes Research.2021; 2021: 1. CrossRef

Obesity and Metabolic Syndrome
Premeal Consumption of a Protein-Enriched, Dietary Fiber-Fortified Bar Decreases Total Energy Intake in Healthy Individuals: Chang Ho Ahn, Jae Hyun Bae, Young Min Cho; Diabetes Metab J. 2019;43(6):879-892. Published online June 25, 2019; DOI: https://doi.org/10.4093/dmj.2018.0202

15,919 View
141 Download
6 Web of Science
9 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background

A premeal load of protein can increase satiety and reduce energy intake. Dietary fiber also conveys metabolic benefits by modulating energy intake. We made a protein-enriched, dietary fiber-fortified bar (PFB) and aimed to investigate its effects on food intake and gut hormone secretion in healthy individuals.

Methods

Twenty subjects with normal glucose tolerance were enrolled. On three separate visits, the subjects received, in a randomized order, one of the following: a PFB containing 73 kcal with 10.7 g of protein and 12.7 g of dietary fiber; a usual bar (UB) containing the same calories as the PFB but only 0.9 g of protein and no dietary fiber; or water (control). After 15 minutes, the subjects had ad libitum intake of a test meal. Food consumption, appetite, and plasma gut hormone levels were measured.

Results

Total energy intake, including the bar and the test meal, was significantly reduced with the PFB preload compared to the water (904.4±534.9 kcal vs. 1,075.0±508.0 kcal, P=0.016). With the UB preload, only the intake of the test meal was reduced (P=0.044) but not the total energy intake (P=0.471) than the water. Fullness was also significantly increased after the PFB. In addition, postprandial glucose levels decreased and glucagon-like peptide-1 levels increased with the PFB compared with both the UB and water.

Conclusion

In healthy individuals, a premeal supplementation of PFB reduced total energy intake and decreased postprandial glucose excursion. This finding necessitates long-term studies regarding clinical use in obesity.

Citations

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Frontiers in Nutrition.2021;[Epub] CrossRef
Response: Premeal Consumption of a Protein-Enriched, Dietary Fiber-Fortified Bar Decreases Total Energy Intake in Healthy Individuals (Diabetes Metab J 2019;43:879–92)
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Diabetes & Metabolism Journal.2020; 44(1): 207. CrossRef
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Journal of Food Biochemistry.2020;[Epub] CrossRef

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