Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White adipose tissue is largely divided into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). These two white adipose tissues are similar in their appearance and lipid storage functions. Nonetheless, emerging evidence has suggested that SAT and VAT have different characteristics and functional roles in metabolic regulation. It is likely that there are intrinsic differences between VAT and SAT. In diet-induced obese animal models, it has been reported that adipogenic progenitors in VAT rapidly proliferate and differentiate into adipocytes. In obesity, VAT exhibits elevated inflammatory responses, which are less prevalent in SAT. On the other hand, SAT has metabolically beneficial effects. In this review, we introduce recent studies that focus on cellular and molecular components modulating adipogenesis and immune responses in SAT and VAT. Given that these two fat depots show different functions and characteristics depending on the nutritional status, it is feasible to postulate that SAT and VAT have different developmental origins with distinct adipogenic progenitors, which would be a key determining factor for the response and accommodation to metabolic input for energy homeostasis.

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• Dietary vitamins A and K are inversely associated with visceral adiposity in US adults: NHANES 2011–2018
  Tatei Haramara Colmenares Villa, Guadalupe Ruiz-Vivanco, Leonardo M. Porchia, Enrique Torres-Rasgado, Esther López-Bayghen, M. Elba Gonzalez-Mejia
  Nutrition Research.2026; 146: 26.     CrossRef
• Cinnamon powder intake enhances the effect of caloric restriction on white adipose tissue in male rats
  Lia Rafaella Ballard Kuhnert, Roberta da Fonseca Coutinho Pontes, Jessika Geisebel Oliveira Neto, Juliana Santos Romão, Carla Eponina de Carvalho Pinto, Karen Jesus Oliveira
  Journal of Molecular Histology.2025;[Epub]     CrossRef
• Prognostic impact of visceral and subcutaneous fat area in stage I-III colon cancer patients with cachexia: a population-based multicenter study
  Xian-wen Liang, Jing Wen, Bing Liu, Sheng-zhong Wang, Jin-cai Wu, Tao Pan
  Frontiers in Nutrition.2025;[Epub]     CrossRef
• Visceral adipocyte metabolic dysfunction in obesity related to altered chromatin accessibility to thyroid hormone receptor
  Hao Zhu, Ji-Ru Zhang, Zhen-Wu Ma, Wen-Na Zhang, Yun Yang, Xuan-Bei Lu, Chen-Yun Gan, Guo-Xian Ding, Jing Yu, Yu Duan, Xiao-Dong Wang
  Gene.2025; 962: 149554.     CrossRef
• snRNA-seq reveals subcutaneous white adipose tissue remodeling upon return to thermoneutrality after cold stimulation
  Yusha Yang, Guanyu Zhang, Ting Yi, Shuran Yang, Shuai Wu, Yongqiang Zhang, Li Zhang, Xi Li, Xiuxuan Wu, Jun Li, Danfeng Yang
  Frontiers in Cell and Developmental Biology.2025;[Epub]     CrossRef
• β-Hydroxybutyrate Reduces Body Weight by Modulating Fatty Acid Oxidation and Beiging in the Subcutaneous Adipose Tissue of DIO Mice
  Violeta Heras, Virginia Mela, Pallavi Kompella, Elena Rojano, Guillermo Paz-López, Lucia Hurtado-García, Almudena Ortega-Gomez, Maria José García-López, María Luisa García-Martín, Juan A. G. Ranea, Francisco J. Tinahones, Isabel Moreno-Indias
  International Journal of Molecular Sciences.2025; 26(11): 5064.     CrossRef
• Association between computed tomography-based adipose tissue parameters and liver transplant outcomes in patients with hepatocellular carcinoma
  Zhihang Hu, Hao Chen, Zuyuan Lin, Chiyu He, Wei Shen, Huigang Li, Zhe Yang, Jinzhen Cai, Shusen Zheng, Di Lu, Xiao Xu
  Clinical Nutrition.2025; 52: 82.     CrossRef
• The Dual Role of Perivascular Adipose Tissue in Vascular Homeostasis and Atherogenesis: From Physiology to Pathological Implications
  Raluca Niculescu, Adina Stoian, Emil Marian Arbănași, Eliza Russu, Dragoș-Florin Babă, Andrei Manea, Mircea Stoian, Florina Ioana Gliga, Iuliu Gabriel Cocuz, Adrian Horațiu Sabău, Dan-Alexandru Szabo, Ovidiu Simion Cotoi
  International Journal of Molecular Sciences.2025; 26(17): 8320.     CrossRef
• Inhibition of lipolysis in visceral adipose tissue from obese mice and humans prevents impairment of endothelial Kir2.1 channels
  Emma C. Hudgins, Erica J. Johnson, Sabita Rokka, Bhaswati Kashyap, Arielle Mahugu, Thanh Nguyen, Anthony R. Tascone, Elizabeth McCarthy, Caitlin Halbert, Ibra S. Fancher
  Channels.2025;[Epub]     CrossRef
• Female Adipose Tissue Sex Steroid Biosynthesis
  Natalia Hetemäki, Tomi S. Mikkola, Hanna Savolainen-Peltonen
  Seminars in Reproductive Medicine.2025; 43(02): 106.     CrossRef
• Visceral Adipose Tissue Accumulation in Children With Obesity and Co-occurring ADHD: A Case-Control Analysis of Body Fat Distribution Patterns
  Muhan Li, Shijie Li, Yan Hu, Chenlu Yang, Aimin Liang
  Journal of Attention Disorders.2025;[Epub]     CrossRef
• Prognostic value of body fat composition in patients with upper tract urothelial carcinoma undergoing radical nephroureterectomy
  Cheng-Hung Liao, Po-Ting Chen, Chin-Chen Chang, Kuo-How Huang, Shih-Chieh Jeff Chueh, Kao-Lang Liu
  Journal of the Formosan Medical Association.2025;[Epub]     CrossRef
• Lipodystrophy as a target to delay premature aging
  Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas
  Trends in Endocrinology & Metabolism.2024; 35(2): 97.     CrossRef
• Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
  Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang
  Cancer Biomarkers.2024; 39(3): 171.     CrossRef
• Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke
  Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Masaki Mogi
  PLOS ONE.2024; 19(1): e0296833.     CrossRef
• NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
  Zheng Wang, Yue Su, Mingyu Zhao, Zhenhua Ma, Jianhui Li, Zhuocheng Hou, Huifeng Li
  Animals.2024; 14(4): 585.     CrossRef
• Visceral adipose of obese mice inhibits endothelial inwardly rectifying K+ channels in a CD36-dependent fashion
  Sabita Rokka, Masoumeh Sadeghinejad, Emma C. Hudgins, Erica J. Johnson, Thanh Nguyen, Ibra S. Fancher
  American Journal of Physiology-Cell Physiology.2024; 326(5): C1543.     CrossRef
• Adipose-derived mesenchymal stromal cells in clinical trials: Insights from single-cell studies
  Anna Kostecka, Natalia Kalamon, Aneta Skoniecka, Magdalena Koczkowska, Piotr M. Skowron, Arkadiusz Piotrowski, Michał Pikuła
  Life Sciences.2024; 351: 122761.     CrossRef
• Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
  Yujie Wu, Ying Sun, Long Chen, Xingyan Tong, Can Liu, Lu Lu, Rui Zhang, Siyuan Wang, Ziyu Chen, Jiaman Zhang, Ziyin Han, Bo Zeng, Mingzhou Li, Long Jin
  Scientific Reports.2024;[Epub]     CrossRef
• Glucose metabolism and radiodensity of abdominal adipose tissue: A 5‐year longitudinal study in a large PET cohort
  Kyoungjune Pak, Severi Santavirta, Seunghyeon Shin, Hyun‐Yeol Nam, Sven De Maeyer, Lauri Nummenmaa
  Clinical Endocrinology.2024; 101(6): 623.     CrossRef
• The association of obesity and the risk of rheumatoid arthritis according to abdominal obesity status: a nationwide population-based study in Korea
  Jung Sun Lee, Ji Seon Oh, Sehee Kim, Ye-Jee Kim, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
  Rheumatology International.2024; 44(12): 2863.     CrossRef
• Anti-Obesity Effects of Pleurotus ferulae Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice
  Seulmin Hong, Seonkyeong Park, Jangho Lee, Soohyun Park, Jaeho Park, Yugeon Lee
  Nutrients.2024; 16(23): 4139.     CrossRef
• Association between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999–2018
  Mingjie Liu, Chendong Wang, Rundong Liu, Yan Wang, Bai Wei
  Lipids in Health and Disease.2024;[Epub]     CrossRef
• Green tea beneficial effects involve changes in the profile of immune cells in the adipose tissue of obese mice
  Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjão, Rosemari Otton
  European Journal of Nutrition.2023; 62(1): 321.     CrossRef
• Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice
  Weihao Chen, Fengyan Meng, Xianyin Zeng, Xiaohan Cao, Guixian Bu, Xiaogang Du, Guozhi Yu, Fanli Kong, Yunkun Li, Tian Gan, Xingfa Han
  International Journal of Molecular Sciences.2023; 24(3): 2308.     CrossRef
• High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life
  Guadalupe L. Rodríguez-González, Sergio De Los Santos, Dayana Méndez-Sánchez, Luis A. Reyes-Castro, Carlos A. Ibáñez, Patricia Canto, Elena Zambrano
  British Journal of Nutrition.2023; 130(5): 783.     CrossRef
• Obesity and the risk of cardiometabolic diseases
  Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia
  Nature Reviews Cardiology.2023; 20(7): 475.     CrossRef
• Abdominal fat and muscle distributions in different stages of colorectal cancer
  Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
  BMC Cancer.2023;[Epub]     CrossRef
• Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
  Sofía Elena Tesolato, Daniel González-Gamo, Ana Barabash, Paula Claver, Sofía Cristina de la Serna, Inmaculada Domínguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio José Torres, Pilar Iniesta
  Cancers.2023; 15(13): 3324.     CrossRef
• Lower subcutaneous fat index predicts bone metastasis in breast cancer
  Wen Wang, Wen-Juan Huang, Ping-Ping Liu, Shuang Fu, Meng-Lin Zhang, Xin Zhang, Rui-Tao Wang, Yuan-Xi Huang
  Cancer Biomarkers.2023; 38(1): 121.     CrossRef
• RabGAP AS160/TBC1D4 deficiency increases long-chain fatty acid transport but has little additional effect on obesity and metabolic syndrome in ADMSCs-derived adipocytes of morbidly obese women
  Agnieszka Mikłosz, Bartłomiej Łukaszuk, Elżbieta Supruniuk, Kamil Grubczak, Magdalena Kusaczuk, Adrian Chabowski
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease
  Griselda Rabadán-Chávez, Rocío I. Díaz de la Garza, Daniel A. Jacobo-Velázquez
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166853.     CrossRef
• Histological pattern and gene expression profiling of thyroid tissue in subjects with obesity
  A. Basolo, A. M. Poma, R. Giannini, G. Ceccarini, C. Pelosini, P. Fierabracci, M. U. Castany, S. Bechi Genzano, C. E. Ambrosini, G. Materazzi, L. Chiovato, F. Basolo, F. Santini, L. Torregrossa
  Journal of Endocrinological Investigation.2022; 45(2): 413.     CrossRef
• Predictors of non-alcoholic fatty liver disease in children
  Menglong Li, Wen Shu, Jiawulan Zunong, Nubiya Amaerjiang, Huidi Xiao, Dan Li, Sten H. Vermund, Yifei Hu
  Pediatric Research.2022; 92(1): 322.     CrossRef
• Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
  Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
  Cell Metabolism.2022; 34(3): 458.     CrossRef
• WT1 in Adipose Tissue: From Development to Adult Physiology
  Karin M. Kirschner, Holger Scholz
  Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
• Shall We Begin the Voyage of Adipose Tissue Exploration?
  Yong Geun Jeon
  Molecules and Cells.2022; 45(6): 362.     CrossRef
• Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner
  Magda Zachara, Pernille Y Rainer, Horia Hashimi, Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke
  The EMBO Journal.2022;[Epub]     CrossRef
• The fates of different types of adipose tissue after transplantation in mice
  Shenglu Jiang, Jiayan Lin, Qian Zhang, Yunjun Liao, Feng Lu, Junrong Cai
  The FASEB Journal.2022;[Epub]     CrossRef
• Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
  Jun Han, Zuoyou Ding, Qiulin Zhuang, Lei Shen, Fan Yang, Szechun Sah, Guohao Wu
  Nutrition & Metabolism.2022;[Epub]     CrossRef
• Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
  Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio
  International Journal of Molecular Sciences.2022; 23(3): 1543.     CrossRef
• Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project
  Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández, Albert Lecube
  Nutrients.2022; 15(1): 203.     CrossRef
• Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
  Alice Chaplin, Ramon Maria Rodriguez, Juan José Segura-Sampedro, Aina Ochogavía-Seguí, Dora Romaguera, Gwendolyn Barceló-Coblijn
  International Journal of Molecular Sciences.2022; 23(21): 13128.     CrossRef
• Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks
  Paula M. Lorenzo, Ana B. Crujeiras
  Food & Function.2021; 12(4): 1402.     CrossRef
• Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
  Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
  International Journal of Molecular Sciences.2021; 22(2): 966.     CrossRef
• Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism
  Jeu Park, Jee Hyung Sohn, Sang Mun Han, Yoon Jeong Park, Jin Young Huh, Sung Sik Choe, Jae Bum Kim
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Ceramides and Sphingosino-1-Phosphate in Obesity
  Ilona Juchnicka, Mariusz Kuźmicki, Jacek Szamatowicz
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
  Christine Bourgeois, Jennifer Gorwood, Anaelle Olivo, Laura Le Pelletier, Jacqueline Capeau, Olivier Lambotte, Véronique Béréziat, Claire Lagathu
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Subcutaneous, but not visceral, adipose tissue as a marker for prognosis in gastric cancer patients with cachexia
  Jun Han, Min Tang, Chaocheng Lu, Lei Shen, Jiaqi She, Guohao Wu
  Clinical Nutrition.2021; 40(9): 5156.     CrossRef
• miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients
  Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu
  Lipids in Health and Disease.2021;[Epub]     CrossRef
• RETRACTED: Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands
  Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
  Cells.2021; 10(12): 3560.     CrossRef
• Obesity: The Crossroads of Opinion, Knowledge, and Opportunity
  L. A. Ruyatkina, D. S. Ruyatkin
  Meditsinskiy sovet = Medical Council.2020; (7): 108.     CrossRef
• Sex Differences in Long-term Metabolic Effects of Maternal Resveratrol Intake in Adult Rat Offspring
  Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
  Endocrinology.2020;[Epub]     CrossRef
• Adipose stem cells in obesity: challenges and opportunities
  Sunhye Shin, Asma S. El-Sabbagh, Brandon E. Lukas, Skylar J. Tanneberger, Yuwei Jiang
  Bioscience Reports.2020;[Epub]     CrossRef
• Clinical and pathogenetic rationale for the prevention and treatment of obesity
  O.M. Korzh
  Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini.2020; 2020(2): 146.     CrossRef
• OBESITY: CLINICAL AND PATHOGENETIC JUSTIFICATION OF PREVENTION AND TREATMENT
  O. M. Korzh
  International Medical Journal.2020; (2): 5.     CrossRef
• The Effect and Mechanism of Subcutaneous and Visceral Adipose Tissue Loss on Gastric Cancer Patients With Cachexia
  Jun Han, Min Tang, Guyue Zhang, Chaocheng Lu, Jiaqi She, Guohao Wu
  SSRN Electronic Journal .2020;[Epub]     CrossRef