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Original Article
- Smaller Mean LDL Particle Size and Higher Proportion of Small Dense LDL in Korean Type 2 Diabetic Patients
- Sunghwan Suh, Hyung-Doo Park, Se Won Kim, Ji Cheol Bae, Alice Hyun-Kyung Tan, Hye Soo Chung, Kyu Yeon Hur, Jae Hyeon Kim, Kwang-Won Kim, Moon-Kyu Lee
- Diabetes Metab J. 2011;35(5):536-542. Published online October 31, 2011
- DOI: https://doi.org/10.4093/dmj.2011.35.5.536
- 5,505 View
- 49 Download
- 15 Crossref
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Abstract
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PubReader Background Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease.
Methods The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-documented coronary artery disease or a myocardial infarction. Peripheral vascular stenosis, carotid artery stenosis (≥50% in diameter) or carotid artery plaque were considered minor vascular complications. Overall vascular complications included both major and minor vascular complications.
Results Diabetic patients had significantly smaller mean-LDL particle size (26.32 nm vs. 26.49 nm) and a higher percentage of sdLDL to total LDL compared to those of subjects without diabetes (21.39% vs. 6.34%). The independent predictors of sdLDL in this study were serum triglyceride level and body mass index (odds ratio [OR], 1.020 with
P <0.001 and OR 1.152 withP <0.027, respectively). However, no significant correlations were found between sdLDL and major vascular complications (P =0.342), minor vascular complications (P =0.573) or overall vascular complications (P =0.262) in diabetic subjects.Conclusion Diabetic patients had a smaller mean-LDL particle size and higher proportion of sdLDL compared to those of subjects without diabetes. Obese diabetic patients with hypertriglyceridemia have an increased risk for atherogenic small dense LDL. However, we could not verify an association between LDL particle size and vascular complications in this study.
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Citations
Citations to this article as recorded by
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Sara Deza, Inmaculada Colina, Oscar Beloqui, José Ignacio Monreal, Estéfani Martínez-Chávez, Julia Maroto-García, Carmen Mugueta, Alvaro González, Nerea Varo
Clinica Chimica Acta.2024; 557: 117897. CrossRef - Nrf2 Signaling Pathway as a Key to Treatment for Diabetic Dyslipidemia and Atherosclerosis
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Sikandar Hayat Khan, Nadeem Fazal, Athar Abbas Gilani Shah, Syed Mohsin Manzoor, Naveed Asif, Aamir Ijaz, Najmusaqib Khan Niazi, Muhammad Yasir
Journal of Lipids.2017; 2017: 1. CrossRef - Effects of Small Dense LDL in Diabetic Nephropathy in Females with Type 2 Diabetes Mellitus
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British Journal of Biomedical Science.2012; 69(3): 99. CrossRef - Small Dense Low-density Lipoprotein and Cardiovascular Disease
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- Evaluation of measured and calculated small dense low-density lipoprotein in capillary blood and association with the metabolic syndrome
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