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Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis (Diabetes Metab J 2023;47:356-65)
Hye Jun Kim, Sung Ryul Shim, Myunghee Hong, Hyun Wook Han
Diabetes Metab J. 2023;47(5):717-718.   Published online September 26, 2023
DOI: https://doi.org/10.4093/dmj.2023.0300
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Original Article
COVID-19
Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis
Hye Jun Kim, Sang Jun Lee, Soonok Sa, Jung Ho Bae, Gyuseon Song, Chae Won Lee, Ju Hee Kim, Sung Ryul Shim, Myunghee Hong, Hyun Wook Han
Diabetes Metab J. 2023;47(3):356-365.   Published online March 6, 2023
DOI: https://doi.org/10.4093/dmj.2022.0129
  • 3,854 View
  • 238 Download
  • 5 Web of Science
  • 5 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Little is known about the adverse events (AEs) associated with coronavirus disease 2019 (COVID-19) vaccination in patients with type 2 diabetes mellitus (T2DM).
Methods
This study used vaccine AE reporting system data to investigate severe AEs among vaccinated patients with T2DM. A natural language processing algorithm was applied to identify people with and without diabetes. After 1:3 matching, we collected data for 6,829 patients with T2DM and 20,487 healthy controls. Multiple logistic regression analysis was used to calculate the odds ratio for severe AEs.
Results
After COVID-19 vaccination, patients with T2DM were more likely to experience eight severe AEs than controls: cerebral venous sinus thrombosis, encephalitis myelitis encephalomyelitis, Bell’s palsy, lymphadenopathy, ischemic stroke, deep vein thrombosis (DVT), thrombocytopenia (TP), and pulmonary embolism (PE). Moreover, patients with T2DM vaccinated with BNT162b2 and mRNA-1273 were more vulnerable to DVT and TP than those vaccinated with JNJ-78436735. Among patients with T2DM administered mRNA vaccines, mRNA-1273 was safer than BNT162b2 in terms of the risk of DVT and PE.
Conclusion
Careful monitoring of severe AEs in patients with T2DM may be necessary, especially for those related to thrombotic events and neurological dysfunctions after COVID-19 vaccination.

Citations

Citations to this article as recorded by  
  • Herbal-based therapeutics for diabetic patients with SARS-Cov-2 infection
    Yousef Rasmi, Ighli di Bari, Shah Faisal, Munima Haque, Pornanong Aramwit, Aline da Silva, Elmira Roshani Asl
    Molecular Biology Reports.2024;[Epub]     CrossRef
  • Tuberculosis vaccines update: Is an RNA-based vaccine feasible for tuberculosis?
    Sasha E. Larsen, Susan L. Baldwin, Rhea N. Coler
    International Journal of Infectious Diseases.2023; 130: S47.     CrossRef
  • Neurological Disorders following COVID-19 Vaccination
    Ying Yang, Lisu Huang
    Vaccines.2023; 11(6): 1114.     CrossRef
  • Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis (Diabetes Metab J 2023;47:356-65)
    Hye Jun Kim, Sung Ryul Shim, Myunghee Hong, Hyun Wook Han
    Diabetes & Metabolism Journal.2023; 47(5): 717.     CrossRef
  • Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis (Diabetes Metab J 2023;47:356-65)
    Jung Hun Ohn
    Diabetes & Metabolism Journal.2023; 47(5): 715.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal