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The Relationship between Lung Function and Metabolic Syndrome in Obese and Non-Obese Korean Adult Males
Soo Kyoung Kim, Kyu Yeon Hur, Yoon Ho Choi, Sun Wook Kim, Jae Hoon Chung, Hee Kyung Kim, Moon-Kyu Lee, Yong-Ki Min, Kwang-Won Kim, Jae Hyeon Kim
Korean Diabetes J. 2010;34(4):253-260.   Published online August 31, 2010
DOI: https://doi.org/10.4093/kdj.2010.34.4.253
  • 4,390 View
  • 32 Download
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

The existence of an association between lung function and metabolic syndrome (MetS) has been debated in cases involving non-obese subjects. To address this debate, we performed a cross-sectional study to investigate the association between lung function and MetS in both obese and non-obese populations.

Methods

The present study consisted of a total of 1,951 Korean male subjects. In this study group, we investigated relationships between lung function and MetS risk factors such as fasting serum glucose, systolic blood pressure (SBP), insulin resistance index, waist circumference (WC), and hemoglobin A1C level.

Results

Forced vital capacity (FVC) values were significantly lower in the MetS group compared with those of the non-MetS group. In both non-obese (body mass index [BMI] < 25 kg/m2) and obese subjects (BMI ≥ 25 kg/m2), fasting serum glucose, hemoglobin A1C level, insulin resistance index, SBP, WC, and the prevalences of diabetes and MetS were significantly higher in subjects in the lowest FVC quartile compared with those in the highest FVC quartile. Odds ratios for the presence of MetS risk factors, after adjusting for age and height, ranged from 1.21 to 1.39 (P < 0.01) for a one standard deviation decrease in FVC.

Conclusion

The results of our study suggest that decreased vital capacity in Korean adult male subjects is associated with MetS, irrespective of obesity.

Citations

Citations to this article as recorded by  
  • The impact of insulin resistance on the association between metabolic syndrome and lung function: the Kangbuk Samsung Health Study
    Jonghoo Lee, Hye Kyeong Park, Min-Jung Kwon, Soo-Youn Ham, Hyun-Il Gil, Si-Young Lim, Jae-Uk Song
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Pulmonary Function in Metabolic Syndrome: A Meta-Analysis
    Ning-ning Fang, Zhi-hao Wang, Shao-hua Li, Yu-yan Ge, Xin Liu, Dong-xin Sui
    Metabolic Syndrome and Related Disorders.2022; 20(10): 606.     CrossRef
  • Determinants of Longitudinal Change of Lung Function in Different Gender in a Large Taiwanese Population Follow-Up Study Categories: Original Investigation
    Chia-Heng Chang, Szu-Chia Chen, Jiun-Hung Geng, Da-Wei Wu, Jiun-Chi Huang, Pei-Yu Wu
    Journal of Personalized Medicine.2021; 11(10): 1033.     CrossRef
  • The Association between Pulmonary Functions and Incident Diabetes: Longitudinal Analysis from the Ansung Cohort in Korea
    Hoon Sung Choi, Sung Woo Lee, Jin Taek Kim, Hong Kyu Lee
    Diabetes & Metabolism Journal.2020; 44(5): 699.     CrossRef
  • Interactive effects of adiposity and insulin resistance on the impaired lung function in asthmatic adults: cross-sectional analysis of NHANES data
    Roham Sadeghimakki, Huw David McCarthy
    Annals of Human Biology.2019; 46(1): 56.     CrossRef
  • Maternal protein restriction during lactation induces early and lasting plasma metabolomic and hepatic lipidomic signatures of the offspring in a rodent programming model
    Aurore Martin Agnoux, Angélina El Ghaziri, Thomas Moyon, Anthony Pagniez, Agnès David, Gilles Simard, Patricia Parnet, El Mostafa Qannari, Dominique Darmaun, Jean-Philippe Antignac, Marie-Cécile Alexandre-Gouabau
    The Journal of Nutritional Biochemistry.2018; 55: 124.     CrossRef
  • Is decreased lung function associated with chronic kidney disease? A retrospective cohort study in Korea
    Soo Kyoung Kim, Ji Cheol Bae, Jong-Ha Baek, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
    BMJ Open.2018; 8(4): e018928.     CrossRef
  • Association between HOMA-IR and Lung Function in Korean Young Adults based on the Korea National Health and Nutrition Examination Survey
    Young Bok Lee, Young Soo Kim, Dong-Hee Lee, Hee Yeon Kim, Jae-Im Lee, Hyo-Suk Ahn, Tae Seo Sohn, Tae-Kyu Lee, Jae Yen Song, Chang Dong Yeo, Mihee Hong, Kyungdo Han, Seong Cheol Jeong, Hiun Suk Chae
    Scientific Reports.2017;[Epub]     CrossRef
  • Spirometric prediction equations and the relationship between metabolic syndrome and spirometric parameters from an island in Fujian, China
    Yu‐Sheng Chen, Xiao‐Qin Li, Hong‐Ru Li, Xiao‐Li Yu, Feng‐Feng Lu, Li‐Ping Huang, Yan Miao, Gui‐Qing Wang, Xiao Lin, Shuang‐Qing Lian, Yun‐Hua Lin, Xiang‐E Zhang, Ting Liu, Yan‐Ling Wu
    The Clinical Respiratory Journal.2017; 11(4): 514.     CrossRef
  • Decline in lung function rather than baseline lung function is associated with the development of metabolic syndrome: A six-year longitudinal study
    Soo Kyoung Kim, Ji Cheol Bae, Jong-Ha Baek, Jae Hwan Jee, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim, Cheng Hu
    PLOS ONE.2017; 12(3): e0174228.     CrossRef
  • The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function
    Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    BMC Pulmonary Medicine.2016;[Epub]     CrossRef
  • Lung function and metabolic syndrome: Findings of National Health and Nutrition Examination Survey 2007–2010 肺功能与代谢综合征:2007–2010全国健康与营养调查研究结果
    Earl S. Ford, Timothy J. Cunningham, Carla I. Mercado
    Journal of Diabetes.2014; 6(6): 603.     CrossRef
  • Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men
    Chang-Hee Kwon, Eun-Jung Rhee, Jae-Uk Song, Jung-Tae Kim, Hyon Joo Kwag, Ki-Chul Sung
    Cardiovascular Diabetology.2012;[Epub]     CrossRef
  • Letter: The Relationship between Lung Function and Metabolic Syndrome in Obese and Non-Obese Korean Adult Males (Korean Diabetes J 2010;34:253-60)
    Bo Kyung Koo
    Korean Diabetes Journal.2010; 34(5): 327.     CrossRef
Association of Kir6.2 and Peroxisome Proliferator-activated Receptor-gamma (PPARgamma) Polymorphisms with Type 2 Diabetes in Koreans.
Jung Eun Lee, Su Won Kim, Hyun Ae Seo, Jae Han Jeon, Seong Su Moon, Hee Kyung Kim, Yun Jeong Doh, Bo Wan Kim, Jung Guk Kim, Min Yoo, In Kyu Lee
Korean Diabetes J. 2007;31(6):455-464.   Published online November 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.6.455
  • 2,288 View
  • 18 Download
AbstractAbstract PDF
BACKGROUND
The type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Several variants may contribute significantly to the risk of type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). In this study, we evaluated the association of Pro12Ala variant of the peroxisome proliferator- activated receptor-gamma and the Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11) with the type 2 diabetes in Korean population. METHOD: This study included 331 subjects consisting of 172 patients with type 2 diabetes and 159 non- diabetic control subjects enrolled from the Kyungpook, Keimyung and Catholic university hospital in Daegu, Korea. We genotyped Kir6.2 (Glu23Lys) and PPARgamma (Pro12Ala) polymorphism and examined their association with the type 2 diabetes. RESULT: In the separate analyses, the Kir6.2 Glu23Lys (P = 0.385) and the PPARgamma Pro12Ala (P = 0.191) polymorphism showed no significant association with type 2 diabetes. In addition, the results of our study showed no evidence of a synergistic interaction between Kir6.2 and PPARgamma gene in each group (P = 0.110, P = 0.276). CONCLUSION: In this study, no association was seen between the genetic polymorphisms of Kir6.2, PPARgamma and type 2 diabetes. However, to clarify whether genetic polymorphisms of these genes contribute to the development of type 2 diabetes, further studies involving larger Korean populations may be needed.
Blood Leptin, Anthropometric and Biochemical Parameters in Type 2 Diabetics.
Seong su Moon, Jae han Jeon, Jung eun Lee, Soon hong Park, Hee kyung Kim, Jeong yun Doh, Ye dal Jung, In kyu Lee, Bo wan Kim, Jung guk Kim
Korean Diabetes J. 2007;31(1):75-82.   Published online January 1, 2007
DOI: https://doi.org/10.4093/jkda.2007.31.1.75
  • 2,216 View
  • 29 Download
  • 1 Crossref
AbstractAbstract PDF
BACKGROUND
Leptin is a hormone which is produced in adipose tissue and regulates food intake and body weight. Leptin is known to correlate with body adiposity such as body mass index. Blood leptin concentration is not different between non-diabetics and diabetics. And It affect not only food intake but may be one of the key factors in the developement of insulin resistance. Recent studies suggest a complex relationship between leptin and insulin resistance or insulin. Therefore we examined the relationship between leptin and anthropometric, biochemical parameters, and insulin resistance in type 2 diabetics. METHOD: The study subjects were 144 patients with type 2 diabetes who visited Kyungpook national university hospital. Anthropometric parameters such as body fat mass, soft lean mass, BMI, arm circumference, skin fold thickness of several sites were measured. Percent body fat were calculated from Brozek fomula, body density were calculated from Jackson and Pollock fomula. Fasting blood leptin and metabolic varables such as C-peptide, HbA1C, insulin, HDL, LDL, TG, total cholesterol, FFA, HOMA-IR were measured. The relationships of blood leptin concentration with clinical data were analyzed with SPSS program. RESULT: Blood leptin concentrations were 8.2 +/- 5.39 ng/mL in women with type 2 diabetes and 5.1 +/- 5.55 ng/mL in men with type 2 diabetes (P-value: 0.01). Percent body fat, FFA were higher in women than men but arm circumference, soft lean mass, waist circumference were higher in men than women (P-value < 0.05). Leptin concentration correlated with BMI, percent body fat, insulin, TG, body fat mass, waist circumference, HOMA-IR. And insulin, C-peptide, total cholesterol, TG were also correlated with leptin only in women with type 2 diabetes. Waist circumference and percent body fat were independent variables which influence blood leptin concentration in multiple regression analysis. CONCLUSION: Blood leptin concentrations are related to parameters such as percent body fat, waist circumference, BMI, body fat mass, insulin, TG, HOMA-IR in type 2 diabetics. The relationship between leptin and obesity or HOMA-IR suggests that leptin may be a one of factors in developement of insulin resistance.

Citations

Citations to this article as recorded by  
  • Prognostic Value of Leptin in Terminally Ill Cancer Patients
    Ji Hyun Hong, So Jin Lee, Sang Mi Kwak, Youn Seon Choi, June Yeong Lee
    The Korean Journal of Hospice and Palliative Care.2012; 15(2): 99.     CrossRef
Review
Endoplasmic Reticulum (ER) Stress and Vascular Complication.
Hee Kyung Kim, In Kyu Lee
Korean Diabetes J. 2006;30(3):145-150.   Published online May 1, 2006
DOI: https://doi.org/10.4093/jkda.2006.30.3.145
  • 1,907 View
  • 20 Download
  • 2 Crossref
AbstractAbstract PDF
No Abstract available.

Citations

Citations to this article as recorded by  
  • Binding of silver nanowaste using jellyfish immune reaction extract and an assessment of aquatic toxicity
    Euna Kim, Min-Kyeong Yeo, Bong Gu Lee, Sun Woo Geum
    Molecular & Cellular Toxicology.2022; 18(3): 339.     CrossRef
  • Metformin Down-regulates TNF-α Secretion via Suppression of Scavenger Receptors in Macrophages
    Bobae Hyun, Seulmee Shin, Aeri Lee, Sungwon Lee, Youngcheon Song, Nam-Joo Ha, Kyung-Hea Cho, Kyungjae Kim
    Immune Network.2013; 13(4): 123.     CrossRef

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