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Diabetes Metab J : Diabetes & Metabolism Journal



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2 "Gary Sweeney"
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Altered Transendothelial Transport of Hormones as a Contributor to Diabetes
Nanyoung Yoon, Thanh Q. Dang, Helen Chasiotis, Scott P. Kelly, Gary Sweeney
Diabetes Metab J. 2014;38(2):92-99.   Published online April 18, 2014
  • 4,277 View
  • 36 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   

The vascular endothelium is a dynamic structure responsible for the separation and regulated movement of biological material between circulation and interstitial fluid. Hormones and nutrients can move across the endothelium either via a transcellular or paracellular route. Transcellular endothelial transport is well understood and broadly acknowledged to play an important role in the normal and abnormal physiology of endothelial function. However, less is known about the role of the paracellular route. Although the concept of endothelial dysfunction in diabetes is now widely accepted, we suggest that alterations in paracellular transport should be studied in greater detail and incorporated into this model. In this review we provide an overview of endothelial paracellular permeability and discuss its potential importance in contributing to the development of diabetes and associated complications. Accordingly, we also contend that if better understood, altered endothelial paracellular permeability could be considered as a potential therapeutic target for diabetes.


Citations to this article as recorded by  
  • Use of 2-dimensional cell monolayers and 3-dimensional microvascular networks on microfluidic devices shows that iron increases transendothelial adiponectin flux via inducing ROS production
    Nanyoung Yoon, Seunggyu Kim, Hye Kyoung Sung, Thanh Q. Dang, Jessie S. Jeon, Gary Sweeney
    Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(2): 129796.     CrossRef
  • Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space
    Simone C. da Silva Rosa, Meilian Liu, Gary Sweeney
    Physiology.2021; 36(3): 134.     CrossRef
  • Tracking adiponectin biodistribution via fluorescence molecular tomography indicates increased vascular permeability after streptozotocin-induced diabetes
    Nanyoung Yoon, Keith Dadson, Thanh Dang, Teresa Chu, Nina Noskovicova, Boris Hinz, Adeline Raignault, Eric Thorin, Seunggyu Kim, Jessie S. Jeon, James Jonkman, Trevor D. McKee, Justin Grant, Jeffrey D. Peterson, Scott P. Kelly, Gary Sweeney
    American Journal of Physiology-Endocrinology and Metabolism.2019; 317(5): E760.     CrossRef
  • Overview of the Components of Cardiac Metabolism
    Elizabeth A. Hausner, Susan A. Elmore, Xi Yang
    Drug Metabolism and Disposition.2019; 47(6): 673.     CrossRef
  • Emerging Roles of Vascular Endothelium in Metabolic Homeostasis
    Xinchun Pi, Liang Xie, Cam Patterson
    Circulation Research.2018; 123(4): 477.     CrossRef
  • Transendothelial movement of adiponectin is restricted by glucocorticoids
    Thanh Q Dang, Nanyoung Yoon, Helen Chasiotis, Emily C Dunford, Qilong Feng, Pingnian He, Michael C Riddell, Scott P Kelly, Gary Sweeney
    Journal of Endocrinology.2017; 234(2): 101.     CrossRef
  • Insulin access to skeletal muscle is impaired during the early stages of diet‐induced obesity
    Josiane L. Broussard, Ana V.B. Castro, Malini Iyer, Rebecca L. Paszkiewicz, Isaac Asare Bediako, Lidia S. Szczepaniak, Edward W. Szczepaniak, Richard N. Bergman, Cathryn M. Kolka
    Obesity.2016; 24(9): 1922.     CrossRef
  • Temporal and Molecular Analyses of Cardiac Extracellular Matrix Remodeling following Pressure Overload in Adiponectin Deficient Mice
    Keith Dadson, Subat Turdi, Stellar Boo, Boris Hinz, Gary Sweeney, Nikolaos Frangogiannis
    PLOS ONE.2015; 10(4): e0121049.     CrossRef
Functional and Mechanistic Integration of Infection and the Metabolic Syndrome
Peter Sommer, Gary Sweeney
Korean Diabetes J. 2010;34(2):71-76.   Published online April 30, 2010
  • 3,527 View
  • 28 Download
  • 14 Crossref
AbstractAbstract PDFPubReader   

The metabolic syndrome refers to a well defined group of risk factors, including central obesity and inflammation, for the development of diabetes and cardiovascular disease. Interestingly, many studies have recently led to the emergence of somewhat unexpected relationships between several infectious diseases and various aspects of the metabolic syndrome. Our understanding of the mechanisms underlying these interactions is also rapidly developing and some of these are summarized in this article. We will focus first on bacterial infection, and most notably the role of gut microbiota in regulaton of both obesity and inflammation. In particular, we focus on the role of inflammasomes and propose that understanding the role of Toll-like receptors and Nod-like receptors in the pathogenesis of inflammatory disorders with or without infection may provide novel targets for prevention and/or treatment of associated diseases. Secondly, chronic bacterial or viral infection and emerging links with metabolism will be reviewed. Finally, consideratons of biomarkers for metabolic syndrome, in particular lipocalin-2, and their link with infection will be discussed.


Citations to this article as recorded by  
  • The Antimicrobial Activity of Origanum vulgare L. Correlated with the Gastrointestinal Perturbation in Patients with Metabolic Syndrome
    Timea Claudia Ghitea, Amina El-Kharoubi, Mariana Ganea, Erika Bimbo-Szuhai, Tiberiu Sebastian Nemeth, Gabriela Ciavoi, Monica Foghis, Luciana Dobjanschi, Annamaria Pallag, Otilia Micle
    Molecules.2021; 26(2): 283.     CrossRef
  • COVID-19 severity in relation to sociodemographics and vitamin D use
    Darya Saeed Abdulateef, Heshu Sulaiman Rahman, Jamal Mahmood Salih, Sangar Mahmoud Osman, Trifa Abdalla Mahmood, Shirwan Hama Salih Omer, Rana Adnan Ahmed
    Open Medicine.2021; 16(1): 591.     CrossRef
  • Iron Reshapes the Gut Microbiome and Host Metabolism
    Amy Botta, Nicole G. Barra, Nhat Hung Lam, Samantha Chow, Kostas Pantopoulos, Jonathan D. Schertzer, Gary Sweeney
    Journal of Lipid and Atherosclerosis.2021; 10(2): 160.     CrossRef
  • Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection
    Anil Pant, Lara Dsouza, Zhilong Yang, Benjamin Gewurz, Vinayaka R. Prasad
    mBio.2021;[Epub]     CrossRef
  • Factors increasing the risk of mortality and morbidity due to coronavirus infection in patients with metabolic syndrome
    Altansuvd Enkhtur, Joon-Sup Yoon, Chang-Woo Lee
    Precision and Future Medicine.2020; 4(3): 83.     CrossRef
  • Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes
    Erfei Song, Sofhia V. Ramos, Xiaojing Huang, Ying Liu, Amy Botta, Hye Kyoung Sung, Patrick C. Turnbull, Michael B. Wheeler, Thorsten Berger, Derek J. Wilson, Christopher G. R. Perry, Tak W. Mak, Gary Sweeney
    Proceedings of the National Academy of Sciences.2018; 115(7): 1576.     CrossRef
  • Tuberculosis of the Breast: An Initial Presentation of the Metabolic Syndrome with Type 2 Diabetes Mellitus in a Young Nigerian Woman
    M. A. Adeiza, R. Yusuf, A. A. Liman, P. Abur, F. Bello, A. A. Abba
    Case Reports in Infectious Diseases.2016; 2016: 1.     CrossRef
  • Systematic Review of the Relation Between Intestinal Microbiota and Toll-Like Receptors in the Metabolic Syndrome: What Do We Know So Far?
    José Pedro Portela-Cidade, Marta Borges-Canha, Adelino Ferreira Leite-Moreira, Pedro Pimentel-Nunes
    GE Portuguese Journal of Gastroenterology.2015; 22(6): 240.     CrossRef
  • Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome
    Seung Han, Kyoung Ha, Ja Jeon, Hae Kim, Kwan Lee, Dae Kim
    International Journal of Environmental Research and Public Health.2015; 12(9): 11396.     CrossRef
  • Regulation of Iron and Its Significance in Obesity and Complications
    Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney
    The Korean Journal of Obesity.2014; 23(4): 222.     CrossRef
  • Direct effects of adipokines on the heart: focus on adiponectin
    Min Park, Gary Sweeney
    Heart Failure Reviews.2013; 18(5): 631.     CrossRef
  • The Thioredoxin System as a Therapeutic Target in Human Health and Disease
    Dler Faieeq Darweesh Mahmood, Amna Abderrazak, Khadija El Hadri, Thomas Simmet, Mustapha Rouis
    Antioxidants & Redox Signaling.2013; 19(11): 1266.     CrossRef
  • Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans
    Zhen Wang, Hong Zhang, Xu-Hui Shen, Kui-Li Jin, Guo-fen Ye, Wei Qiu, Li Qian, Bo Li, Yong-Hong Zhang, Guo-Ping Shi
    Annals of Medicine.2013; 45(3): 220.     CrossRef
  • Immunoglobulin E and Mast Cell Proteases Are Potential Risk Factors of Human Pre-Diabetes and Diabetes Mellitus
    Zhen Wang, Hong Zhang, Xu-Hui Shen, Kui-Li Jin, Guo-fen Ye, Li Qian, Bo Li, Yong-Hong Zhang, Guo-Ping Shi, Yiqing Song
    PLoS ONE.2011; 6(12): e28962.     CrossRef

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