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Associations between Fatness, Fitness, IGF and IMT among Obese Korean Male Adolescents
Eun Sung Kim, Ji-Hye Park, Mi Kyung Lee, Dong Hoon Lee, Eun Seok Kang, Hyun Chul Lee, Yoonsuk Jekal, Justin Y. Jeon
Diabetes Metab J. 2011;35(6):610-618.   Published online December 26, 2011
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  • 44 Download
  • 15 Crossref
AbstractAbstract PDFPubReader   

The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents.


A total of 225 high school males with a mean age of 16.96±0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured.


The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein.


There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.


Citations to this article as recorded by  
  • Relationship between insulin-like growth factor-1, insulin resistance and metabolic profile with pre-obesity and obesity in children
    Marina Jaksic, Milica Martinovic, Najdana Gligorovic-Barhanovic, Tanja Antunovic, Mirjana Nedovic-Vukovic
    Journal of Pediatric Endocrinology and Metabolism.2021; 34(3): 301.     CrossRef
  • Enerji Metabolizması, Obezite ve Hormonlar
    Derya Selda SINAR, Nasuh Evrim ACAR, İrfan YILDIRIM
    Türkiye Spor Bilimleri Dergisi.2020; 4(1): 30.     CrossRef
  • Carotid Intima‐Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass
    Matthew Arnold, Andrew Linden, Robert Clarke, Yu Guo, Huaidong Du, Zheng Bian, Eric Wan, Meng Yang, Liang Wang, Yuexin Chen, Jianwei Chen, Huajun Long, Qijun Gu, Rory Collins, Liming Li, Zhengming Chen, Sarah Parish, Junshi Chen, Jun Lv, Richard Peto, Rob
    Journal of the American Heart Association.2019;[Epub]     CrossRef
  • Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity
    Pauline Mury, Erica N. Chirico, Mathilde Mura, Antoine Millon, Emmanuelle Canet-Soulas, Vincent Pialoux
    Sports Medicine.2018; 48(12): 2725.     CrossRef
  • Protein Intake in Infancy and Carotid Intima Media Thickness at 5 Years - A Secondary Analysis from a Randomized Trial
    Dariusz Gruszfeld, Martina Weber, Monika Nowakowska-Rysz, Roman Janas, Rainer Kozlik-Feldmann, Annick Xhonneux, Clotilde Carlier, Enrica Riva, Elvira Verduci, Ricardo Closa-Monasterolo, Joaquin Escribano, Anna Dobrzanska, Berthold Koletzko
    Annals of Nutrition and Metabolism.2015; 66(1): 51.     CrossRef
  • High Prevalence of Cardiometabolic Risk Factors in Hispanic Adolescents: Correlations with Adipocytokines and Markers of Inflammation
    Cynthia M. Pérez, Ana P. Ortiz, Enrique Fuentes-Mattei, Guermarie Velázquez-Torres, Damarys Santiago, Katya Giovannetti, Raúl Bernabe, Mong-Hong Lee, Sai-Ching J. Yeung
    Journal of Immigrant and Minority Health.2014; 16(5): 865.     CrossRef
  • Cross-sectional and longitudinal relation of IGF1 and IGF-binding protein 3 with lipid metabolism
    Marie-Luise Eggert, Henri Wallaschofski, Anne Grotevendt, Matthias Nauck, Henry Völzke, Stefanie Samietz, Nele Friedrich
    European Journal of Endocrinology.2014; 171(1): 9.     CrossRef
  • Association between insulin‐like growth factor‐1, measures of overnutrition and undernutrition and insulin resistance in black adolescents living in the north‐west province, South Africa
    Ramoteme L. Mamabolo, Cristiana Berti, Makama A. Monyeki, H. Salome Kruger
    American Journal of Human Biology.2014; 26(2): 189.     CrossRef
  • Prevalence and trend of dyslipidaemia from 1996 to 2006 among normal and overweight adolescents in Taiwan
    Philip Kuo, Jhu-Ting Syu, Isabel Lin Tzou, Pi-Yun Chen, Hsiu-Yueh Su, Nain-Feng Chu
    BMJ Open.2014; 4(2): e003800.     CrossRef
  • Relationship of serum insulin-like growth factor I (IGF-I) with nutritional status in pediatric patients with malignant diseases—a single Romanian center experience
    Mihaela Ioana Chinceşan, Oana Mărginean, Ana-Maria Pitea, Minodora Dobreanu
    European Journal of Pediatrics.2013; 172(10): 1401.     CrossRef
  • Gene x environment interactions impact endometrial function and the menstrual cycle: PROGINS, life history, anthropometry, and physical activity
    Elizabeth J. Rowe, Toby K. Eisenstein, Joseph Meissler, L. Christie Rockwell
    American Journal of Human Biology.2013; 25(5): 681.     CrossRef
  • Insulin-like growth factor-I (IGF-I) and clinical nutrition
    Callum Livingstone
    Clinical Science.2013; 125(6): 265.     CrossRef
  • Higher Body Mass Index Leads to Longer Operative Time in Total Knee Arthroplasty
    Barthelemy Liabaud, David A. Patrick, Jeffrey A. Geller
    The Journal of Arthroplasty.2013; 28(4): 563.     CrossRef
  • The Relationship Between Fitness, BMI and Risk Factors of Metabolic Syndrome Among University Students in Korea
    Dong-il Kim, Ji Young Kim, Mi Kyoung Lee, Hae-Dong Lee, Ji-Won Lee, Justin Y. Jeon
    The Korean Journal of Obesity.2012; 21(2): 99.     CrossRef
  • The Insulin-Like Growth Factor System and Nutritional Assessment
    Callum Livingstone
    Scientifica.2012; 2012: 1.     CrossRef
Effects of Walking and Physical Activity on Glucose Regulation among Type 2 Diabetics.
Yoonsuk Jekal, Mi Kyung Lee, Eun Sung Kim, Ji Hye Park, Hyun Ji Lee, Seung Jin Han, Eun Seok Kang, Hyun Chul Lee, So Hun Kim, Justin Y Jeon
Korean Diabetes J. 2008;32(1):60-67.   Published online February 1, 2008
  • 2,336 View
  • 39 Download
  • 7 Crossref
AbstractAbstract PDF
Physical activity, especially walking is strongly recommended to control blood glucose among type 2 diabetic patients. Furthermore, physical activity is one of the most important tools to prevent secondary diabetes complications among type 2 diabetic patients such as retinopathy, nephropathy, neuropathy etc. The purpose of the study was to examine the association between the level of walking and physical activity and glucose control among Korean adults with type 2 diabetes. METHODS: A total of 250 patients with type 2 diabetes (98 males and 152 females) were recruited (mean age = 62.1 +/- 10.2 years) in the current study. The height, weight, waist and hip circumference were measured, and the level of physical activity and total walking hour were measured by physical activity scale for elderly (PASE). High density lipoprotein cholesterol (HDL-C), total cholesterol, triglyceride, fasting glucose and oral glucose tolerance test, creatinine, uric acid, total protein, albumin, hemoglobin A1c were measured. RESULTS: After adjusting for potential covariates such as age, education, occupation income, smoking, and drinking, male patients who spent least time in walking were more likely to have 2 hour serum glucose level in oral glucose tolerance above 200 mg/dL than counterparts who spent most time in walking with age adjusted (Relative Risk (RR) = 11.75, 95% Confidence Interval (CI) = 1.94-71.00). Male patients who were in the least active group were 5.92 time (95% CI = 1.39-25.28) more likely to have 2 hour serum glucose level in oral glucose tolerance over 200 mg/dL than counterparts in the most active group. However, there was no significant finding in females. CONCLUSIONS: The current study showed that physical activity and walking are effective method to maintain glucose tolerance among type 2 diabetic male patients.


Citations to this article as recorded by  
  • 호남권 지역주민의 건강행태와 만성질환 관리현황
    선아 김, 정은 이
    Public Health Weekly Report.2024; 17(2): 46.     CrossRef
  • Impact of the COVID-19 Pandemic on Obesity, Metabolic Parameters and Clinical Values in the South Korean Adult Population
    Anna Kim, Eun-yeob Kim, Jaeyoung Kim
    Journal of Clinical Medicine.2024; 13(10): 2814.     CrossRef
  • A Study Analyzing the Relationship among Impaired Fasting Glucose (IFG), Obesity Index, Physical Activity, and Beverage and Alcohol Consumption Frequency in 20s and 30s:The Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2015
    Yujin Lee, Jung-Hyun Kim
    The Korean Journal of Community Living Science.2022; 33(1): 19.     CrossRef
  • Travel Guidance for People with Diabetes
    Izadi Morteza, Hosseini Mahboobeh Sadat, Pazham Hossein
    International Journal of Travel Medicine and Global Health.2015; 3(4): 149.     CrossRef
  • Prevalence and Risk Factors of Type 2 Diabetes According to Gender among Korean Employees
    Sang-A Kim, Woong-Sub Park, Su Jeong Yu, Young Ran Chae, Donghee Choi
    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(11): 7589.     CrossRef
  • Low Levels of Physical Activity Are Associated with Increased Metabolic Syndrome Risk Factors in Korean Adults
    Dong Hoon Lee, Yoon Myung Kim, Yoonsuk Jekal, Sukyung Park, Kyong-Chol Kim, Masayo Naruse, Sun Hyun Kim, Sang-Hwan Kim, Ji-Hye Park, Mi Kyung Lee, Sang Hui Chu, Justin Y. Jeon
    Diabetes & Metabolism Journal.2013; 37(2): 132.     CrossRef
  • Association between Obesity and Physical Fitness, and Hemoglobin A1c Level and Metabolic Syndrome in Korean Adults
    Yoonsuk Jekal, Mi-Kyung Lee, Sukyung Park, Seung-Hwan Lee, Jun-Young Kim, Jung-Ui Kang, Masayo Naruse, Sang-Hwan Kim, Sun-Hyeon Kim, Sang Hui Chu, Sang-Hoon Suh, Justin Y Jeon
    Korean Diabetes Journal.2010; 34(3): 182.     CrossRef
Clinical Characteristics and Pregnancy Outcome in Korean Women with Type I & Type II Diabetes Mellitus.
Yoon Huh, Dong Won Suh, Hak Chul Jang, Chang Hoon Yim, Ki Ok Han, Hyun Ku Yoon, In Kwon Han, Hun Ki Min, Eun Sung Kim, Moon Young Kim, Hyun Mi Ryu, Sung Won Yang, Hae Kyoung Han
Korean Diabetes J. 1998;22(3):353-362.   Published online January 1, 2001
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  • 18 Download
AbstractAbstract PDF
The prevalence of diabetes is gradually increasing iin Korean. Moreover, the prevalence of pregnancy complicated by established diabetes seems to be increasing. During the past decades, advances in the diabetes care as well as advances in fetal surveillance and neonatal care, have continued to improve pregnancy outcome of women with diabetes. However, the incidence of congenital anomalies and spontaneous abortion as well as the perinatal morbidity in the women with diabetes are still higher compared to those of the general population. In this study, we estimated the prevalence of prepmncy complicated by both type 1 and type 2 diabetes and described the clinical characteristics and outcome of diabetic pregnancies. METHODS: We analyzed data from four sources: 1) the mother(type and duration of diabetes, diabetic complication, preconceptional care), 2) obstetric outcome(method of delivery, obstetric complication), 3) neonatal outcome(birth weight, perinatal complication, congenital anomaly), 4) glycemic control during pregnancy, of women with pregestational diabetes delivered newborns at Samsung Cheil Hospital from 1992 to 1995. RESULTS: During the study period, 34 singleton infants were delivered by the 28 women with diabetes. The diabetic pregnancy was present in 0.14% of total deliveries in Samsung Cheil Hospital. Patients with IDDM comprised 18%(6/34) of total diabetic pregnancies, 82%(28/34) had NIDDM. The duration of diabetes was 6.3 and 2.1 years in patients with IDDM and NIDDM, respectively. Two IDDM patients presented with proliferative retinopathy, and 3 background retinopathy, one in IDDM and 2 in NIDDM. Three patients with IDDM and 2 patients with NIDDM had diabetic nephropathy. Insulin requirement during pregnancy was increased about 2 times at the time of delivery when compared to the initial in women with IDDM and NIDDM. Preeclampsia was the most common obstetric compliications, which were more frequently observed in women with diabetic complications. LGA was present in 43% of women with NIDDM. One infant of mother with NIDDM, delivered at 28 weeks gestation, was died because of respiratory distress and one infant of mother with IDDM had a congenital heart disease(TOF). Only 3 patients scught for the preconceptional care before pregnancy. CONCLUSION: Pregnancies complicated by diabetes was more frequent than was expected, even though it was much less than the rates in North America. Only 9% of women with diabetes had preconceptional care before pregnancy. The importance of planned pregnancy and prepregnancy counseling should be addressed in women with diabetes of child bearing age.

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