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Original Article
- Obesity and Metabolic Syndrome
- The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults
- Jeong Mi Kim, Bo Hyun Kim, Hyungi Lee, Eun Heui Kim, Mijin Kim, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, In Joo Kim, Yong Ki Kim
- Diabetes Metab J. 2019;43(6):867-878. Published online April 3, 2019
- DOI: https://doi.org/10.4093/dmj.2018.0130
- 7,020 View
- 78 Download
- 19 Web of Science
- 18 Crossref
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Abstract
PDF
Supplementary Material
PubReader Background Thyroid disease and metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to investigate the correlation between thyroid hormones and obesity sub-phenotypes using nationwide data from Korea, a country known to be iodine replete.
Methods This study was based on data obtained from the sixth Korea National Health and Nutrition Examination Survey, administered from 2013 to 2015. A total of 13,873 participants aged ≥19 years were included, and classified into four groups: metabolically healthy non-obesity (MHNO), metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), and metabolically unhealthy obesity (MUO) by body fat on the basis of body mass index and metabolic health.
Results At baseline, serum free thyroxine (fT4) values were significantly higher in the MHNO phenotype (MHNO, 1.27±0.01 ng/dL; MHO, 1.25±0.01 ng/dL; MUNO, 1.24±0.01 ng/dL; MUO, 1.24±0.01 ng/dL,
P <0.001) in total study population. However, this significant association no longer remained after adjustment for age, urine iodine concentration, and smoking (P =0.085). After adjustment for confounders, statistically significant association was observed between lower thyroid stimulating hormone (TSH) and MHNO phenotype (P =0.044). In men participants (not women), higher fT4 values were significantly associated with MHNO phenotype (P <0.001). However, no significant association was observed between thyroid function (TSH or fT4) and obesity phenotypes in groups classified by age (cutoff age of 55 years).Conclusion Although there was a difference by age and sex, we found that the decrease of TSH and the increase of fT4 values were associated with MHNO.
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Citations
Citations to this article as recorded by
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Yingkun Qiu, Qinyu Liu, Yinghua Luo, Jiadi Chen, Qingzhu Zheng, Yuping Xie, Yingping Cao
Frontiers in Endocrinology.2024;[Epub] CrossRef - Exploring the diagnostic performance of machine learning in prediction of metabolic phenotypes focusing on thyroid function
Hyeong Jun Ahn, Kyle Ishikawa, Min-Hee Kim, Vijayalakshmi Kakulapati
PLOS ONE.2024; 19(6): e0304785. CrossRef - Association between thyroid hormone resistance and obesity: a cross‐sectional study and mouse stimulation test
Zhihui Wang, Huimin Yu, Kai Wang, Junming Han, Yongfeng Song
Obesity.2024; 32(8): 1483. CrossRef - Association between thyroid function and obesity phenotypes in healthy euthyroid individuals: an investigation based on Tehran Thyroid Study
Behnaz Abiri, Amirhossein Ramezani Ahmadi, Maryam Mahdavi, Atieh Amouzegar, Majid Valizadeh
European Journal of Medical Research.2023;[Epub] CrossRef - Characteristics of the metabolically unhealthy phenotype in menopausal resistance training practitioners
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Endocrine.2020; 68(3): 573. CrossRef - The role of thyroid hormone in metabolism and metabolic syndrome
Patrícia de Fátima dos Santos Teixeira, Patrícia Borges dos Santos, Carmen Cabanelas Pazos-Moura
Therapeutic Advances in Endocrinology and Metabolism.2020;[Epub] CrossRef - Characteristics of Serum Thyroid Hormones in Different Metabolic Phenotypes of Obesity
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Frontiers in Endocrinology.2020;[Epub] CrossRef
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