Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Search

Page Path
HOME > Search
1 "Da Eun Kwon"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
Epidemiology
Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Yeonju La, Da Eun Kwon, Sang Hoon Han
Diabetes Metab J. 2019;43(6):815-829.   Published online January 21, 2019
DOI: https://doi.org/10.4093/dmj.2018.0167
  • 5,180 View
  • 77 Download
  • 19 Web of Science
  • 18 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

A latent cytomegalovirus (CMV) cause chronic inflammation through undesirable inflation of cell-mediated immune response. CMV immunoglobulin G has been associated with cardiovascular disease and type 1 diabetes mellitus. We evaluated impact of CMV diseases on new-onset type 2 diabetes mellitus (T2DM).

Methods

From the Korean Health Insurance Review and Assessment Service claim database of entire population with 50 million, we retrieved 576 adult case group with CMV diseases diagnosed with International Statistical Classification of Diseases and Related-Health Problems 10th Revision (ICD-10) B25 code between 2010 and 2014 after exclusion of patients with T2DM to 2006. The 2,880 control patients without T2DM from 2006 to cohort entry point were selected between 2010 and 2014 by age, sex matching with case group. The subjects without new-onset T2DM were followed until 2015. T2DM, hypertension (HTN), dyslipidemia (DYS), and end-stage renal disease (ESRD) were coded as ICD-10.

Results

The frequency of new-onset T2DM in case group was significantly higher than that in control (5.6% vs. 2.2%, P<0.001). The group with T2DM (n=95) had higher incidence of CMV diseases than the group without T2DM (n=3,361) (33.7% vs. 16.2%, P<0.001). In multivariate regression model adjusted by age, sex, lower income, HTN, and DYS, the incidence rate (IR) of T2DM in case group was significantly higher than that in the control group (IR per 1,000, 19.0 vs. 7.3; odds ratio, 2.1; 95% confidence interval, 1.3 to 3.2). The co-existence of HTN, DYS, and ESRD with CMV diseases did not influence the IR of T2DM.

Conclusion

CMV diseases increase the patients' risk of developing T2DM.

Citations

Citations to this article as recorded by  
  • An analysis of risk factors for spontaneously occurring type 2 diabetes mellitus in rhesus macaques (Macaca mulatta)
    John P. Capitanio, Laura A. Del Rosso, JoAnn Yee, Marie‐Josee Marie‐France Lemoy
    Journal of Medical Primatology.2024;[Epub]     CrossRef
  • Virus-induced diabetes mellitus: revisiting infection etiology in light of SARS-CoV-2
    Sundararaj Stanleyraj Jeremiah, Abu Saleh Md Moin, Alexandra E. Butler
    Metabolism.2024; 156: 155917.     CrossRef
  • Is Pollution the Primary Driver of Infectious Syndemics?
    Merrill Singer
    Pathogens.2024; 13(5): 370.     CrossRef
  • Connecting the Dots: How Herpes Viruses Influence Type 2 Diabetes: Insights from Experimental Researches
    Ushna Zameer, Eisha Saqib, Muhammad Salman Munshi, Samia Rohail
    Clinical Medicine Insights: Endocrinology and Diabetes.2024;[Epub]     CrossRef
  • Infections and immunity: associations with obesity and related metabolic disorders
    Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
    Journal of Pathology and Translational Medicine.2023; 57(1): 28.     CrossRef
  • The effects of cytomegalovirus on brain structure following sport-related concussion
    Jonathan Savitz, Bryna D Goeckner, Bart N Ford, T Kent Teague, Haixia Zheng, Jaroslaw Harezlak, Rebekah Mannix, L Tugan Muftuler, Benjamin L Brett, Michael A McCrea, Timothy B Meier
    Brain.2023; 146(10): 4262.     CrossRef
  • Does COVID-19 Infection Increase the Risk of Diabetes? Current Evidence
    Rachel Wong, Emily Lam, Carolyn T. Bramante, Steven G. Johnson, Jane Reusch, Kenneth J. Wilkins, Hsin-Chieh Yeh
    Current Diabetes Reports.2023; 23(8): 207.     CrossRef
  • Epidemiological changes in cytomegalovirus end-organ diseases in a developed country: A nationwide, general-population-based study
    Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Joohee Lim, Yeonju La, Da Eun Kwon, Sang Hoon Han
    Journal of Microbiology, Immunology and Infection.2022; 55(5): 812.     CrossRef
  • Human MicroRNAs Attenuate the Expression of Immediate Early Proteins and HCMV Replication during Lytic and Latent Infection in Connection with Enhancement of Phosphorylated RelA/p65 (Serine 536) That Binds to MIEP
    Yeon-Mi Hong, Seo Yeon Min, Dayeong Kim, Subin Kim, Daekwan Seo, Kyoung Hwa Lee, Sang Hoon Han
    International Journal of Molecular Sciences.2022; 23(5): 2769.     CrossRef
  • Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
    Swapna Thomas, Allal Ouhtit, Hebah A. Al Khatib, Ali H. Eid, Shilu Mathew, Gheyath K. Nasrallah, Mohamed M. Emara, Muna A. Al Maslamani, Hadi M. Yassine
    Journal of Infection and Public Health.2022; 15(4): 412.     CrossRef
  • Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort
    Tim Woelfle, Birgit Linkohr, Tim Waterboer, Barbara Thorand, Jochen Seissler, Marc Chadeau-Hyam, Annette Peters
    Diabetologia.2022; 65(8): 1328.     CrossRef
  • Association of pyogenic spondylitis with congestive heart failure in Korea: a nationwide longitudinal cohort study
    Chong Jin Park, Seung Hun Sheen, Jeong Gyun Kim, Hakyung Kim, Yeo Song Kim, In-bo Han, Je Beom Hong, Chun Kee Chung, Seil Sohn
    Journal of Korean Society of Geriatric Neurosurgery.2022; 18(1): 8.     CrossRef
  • The Role of CMV Infection in Primary Lesions, Development and Clinical Expression of Atherosclerosis
    Carmen Valentina Cristescu, Sophie Alain, Simona Maria Ruță
    Journal of Clinical Medicine.2022; 11(13): 3832.     CrossRef
  • Type 2 diabetes and viral infection; cause and effect of disease
    Tamara Turk Wensveen, Dora Gašparini, Dario Rahelić, Felix M. Wensveen
    Diabetes Research and Clinical Practice.2021; 172: 108637.     CrossRef
  • Cytomegalovirus Disease, Short-Term Cardiovascular Events and Graft Survival in a Cohort of Kidney Transplant Recipients With High CMV IgG Seroprevalence
    James S. Díaz, Fabián A. Jaimes
    Progress in Transplantation.2021; 31(2): 126.     CrossRef
  • Prevalence of carbohydrate metabolism disorders in patients with new coronavirus infection
    T. N. Markova, M. A. Lysenko, A. A. Ivanova, E. S. Pavlova, A. A. Ponomareva, V. V. Chibisova, T. K. Isaev, D. O. Sinyavkin, A. M. Mkrtumyan
    Diabetes mellitus.2021; 24(3): 222.     CrossRef
  • Immunological Mechanisms of Sickness Behavior in Viral Infection
    Mia Krapić, Inga Kavazović, Felix M. Wensveen
    Viruses.2021; 13(11): 2245.     CrossRef
  • Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study
    Kyoung Hwa Lee, Da Eun Kwon, Kyung Do Han, Yeonju La, Sang Hoon Han
    BMC Neurology.2020;[Epub]     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer