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The Effect of Glycemic Status on Kidney Stone Disease in Patients with Prediabetes
Tzu-Hsien Lien, Jin-Shang Wu, Yi-Ching Yang, Zih-Jie Sun, Chih-Jen Chang
Diabetes Metab J. 2016;40(2):161-166.   Published online April 25, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.2.161
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  • 8 Web of Science
  • 9 Crossref
AbstractAbstract PDFPubReader   
Background

While the evidence supporting a positive association between diabetes mellitus and kidney stone disease (KSD) is solid, studies examining the association between impaired fasting glucose (IFG) and KSD show inconsistent results. Currently, there are no studies examining the relationship between impaired glucose tolerance (IGT) and KSD. The objective of this study is to investigate the effects of different glycemic statuses on KSD. The results may help to motivate patients with diabetes to conform to treatment regimens.

Methods

We conducted a cross sectional study of a population that underwent health check-ups between January 2000 and August 2009 at the Health Evaluation Center of National Cheng Kung University Hospital. A total of 14,186 subjects were enrolled. The following categories of glycemic status were used according to the criteria of the 2009 American Diabetes Association: normal glucose tolerance, isolated IGT, isolated IFG, combined IFG/IGT, and diabetes. The existence of KSD was evaluated using renal ultrasonography, and the presence of any hyperechoic structures causing acoustic shadowing was considered to be indicative of KSD.

Results

The prevalence of KSD was 7.4% (712/9,621), 9.3% (163/1,755), 10.8% (78/719), 12.0% (66/548), and 11.3% (174/1,543) in subjects with NGT, isolated IGT, isolated IFG, combined IFG/IGT, and diabetes, respectively. Isolated IFG, combined IFG/IGT, and diabetes were associated with KSD after adjusting for other clinical variables, but isolated IGT was not. Age (41 to 64 years vs. ≤40 years, ≥65 years vs. ≤40 years), male gender, hypertension, and hyperuricemia were also independently associated with KSD.

Conclusion

Isolated IFG, combined IFG/IGT, and diabetes, but not isolated IGT, were associated with a higher risk of KSD.

Citations

Citations to this article as recorded by  
  • Related Risk Factor Analysis for Upper Urinary Tract Stones in Patients with Abnormal Glucose Metabolism
    泽伟 于
    Advances in Clinical Medicine.2022; 12(02): 749.     CrossRef
  • Nephrolithiasis: A Red Flag for Cardiovascular Risk
    Alessia Gambaro, Gianmarco Lombardi, Chiara Caletti, Flavio Luciano Ribichini, Pietro Manuel Ferraro, Giovanni Gambaro
    Journal of Clinical Medicine.2022; 11(19): 5512.     CrossRef
  • Association between metabolic syndrome components and the risk of developing nephrolithiasis: A systematic review and bayesian meta-analysis
    Ilham Akbar Rahman, Ilham Fauzan Nusaly, Syakri Syahrir, Harry Nusaly, Makbul Aman Mansyur
    F1000Research.2021; 10: 104.     CrossRef
  • Glycemic Status, Insulin Resistance, and the Risk of Nephrolithiasis: A Cohort Study
    Seolhye Kim, Yoosoo Chang, Hyun-Suk Jung, Young Youl Hyun, Kyu-Beck Lee, Kwan Joong Joo, Heung Jae Park, Young-Sam Cho, Hyeonyoung Ko, Eunju Sung, Hocheol Shin, Seungho Ryu
    American Journal of Kidney Diseases.2020; 76(5): 658.     CrossRef
  • Associations between nephrolithiasis and diabetes mellitus, hypertension and gallstones: A meta‐analysis of cohort studies
    Bing‐Biao Lin, Rong‐Hua Huang, Bing‐Liang Lin, Ying‐Kai Hong, Ming‐En Lin, Xue‐Jun He
    Nephrology.2020; 25(9): 691.     CrossRef
  • Risk Factors for Urolithiasis (Review)
    В. А. Слободянюк
    Health of Man.2020; (1): 75.     CrossRef
  • Re: Evidence of Disordered Calcium Metabolism in Adolescent Girls with Type 1 Diabetes: An Observational Study Using a Dual-Stable Calcium Isotope Technique
    Dean G. Assimos
    Journal of Urology.2018; 199(2): 335.     CrossRef
  • Metabolic syndrome and uric acid nephrolithiasis: insulin resistance in focus
    Leonardo Spatola, Pietro Manuel Ferraro, Giovanni Gambaro, Salvatore Badalamenti, Marco Dauriz
    Metabolism.2018; 83: 225.     CrossRef
  • Kidney stones diseases and glycaemic statuses: focus on the latest clinical evidences
    Leonardo Spatola, Claudio Angelini, Salvatore Badalamenti, Silvio Maringhini, Giovanni Gambaro
    Urolithiasis.2017; 45(5): 457.     CrossRef

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