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Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
Cheol Whee Park
Diabetes Metab J. 2014;38(4):252-260.   Published online August 20, 2014
DOI: https://doi.org/10.4093/dmj.2014.38.4.252
  • 6,366 View
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  • 76 Web of Science
  • 69 Crossref
AbstractAbstract PDFPubReader   

With worldwide epidemic of diabetes mellitus, diabetic nephropathy which is one of the major causes of microvascular complication has become a serious concern in Korea as well as the rest of the world. In view of its significance, there is an urgent and paramount need for proper managements that could either deter or slow the progression of diabetic nephropathy. Despite advances in care, ever increasing number of patients suffering from diabetic kidney disease and from end-stage renal disease implies that the current management is not adequate in many aspects. The reasons for these inadequacies compromise lack of early diagnosis, failure to intervene with timely and aggressive manner, and lack of understanding on the kind of interventions required. Another issue equally important for the adequate care of patients with diabetic nephropathy is an understanding of past, present and future epidemiology of diabetic nephropathy which serves, especially in Korea, as a material determining standard diagnosis and treatment and a national health-policy decision.

Citations

Citations to this article as recorded by  
  • N6-methyladenosine RNA methylation in diabetic kidney disease
    Jiaan Huang, Fan Yang, Yan Liu, Yuehua Wang
    Biomedicine & Pharmacotherapy.2024; 171: 116185.     CrossRef
  • Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study
    Geun Woo Lee, Chul Ho Lee, Seong Gyu Kim
    Journal of Yeungnam Medical Science.2023; 40(2): 146.     CrossRef
  • Age at Mortality in Patients with Type 2 Diabetes Who Underwent Kidney Transplantation: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
    Sun Ok Song, Eugene Han, Kang Ju Son, Bong-Soo Cha, Byung-Wan Lee
    Journal of Clinical Medicine.2023; 12(9): 3160.     CrossRef
  • Single‐cell RNA‐seq with spatial transcriptomics to create an atlas of human diabetic kidney disease
    Duo Chen, Mingwei Shao, Yi Song, Gaofei Ren, Feng Guo, Xunjie Fan, Yanyan Wang, Wei Zhang, Guijun Qin
    The FASEB Journal.2023;[Epub]     CrossRef
  • Metabolomic profiling of amino acids study reveals a distinct diagnostic model for diabetic kidney disease
    Jiao Wang, Chunyu Zhou, Qing Zhang, Zhangsuo Liu
    Amino Acids.2023; 55(11): 1563.     CrossRef
  • New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1
    Zhimei Peng, Yanting Liang, Xueying Liu, Jie Shao, Nan Hu, Xinzhou Zhang
    Biomedicine & Pharmacotherapy.2023; 166: 115422.     CrossRef
  • Physical exercise as a friend not a foe in acute kidney diseases through immune system modulation
    Ana Carolina Costanti-Nascimento, Leonilia Brelaz-Abreu, Elayne Bragança-Jardim, Welbert de Oliveira Pereira, Niels Olsen Saraiva Camara, Mariane Tami Amano
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Sodium-dependent glucose transporter 2 inhibitor alleviates renal lipid deposition and improves renal oxygenation levels in newly diagnosed type 2 diabetes mellitus patients: a randomized controlled trial
    Li Zhang, Tongdan Wang, Yan Kong, Haizhen Sun, Yuling Zhang, Junmei Wang, Zhida Wang, Shan Lu, Pei Yu, Saijun Zhou
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Neutrophil lymphocyte ratio: a reliable biomarker for diabetic nephropathy?
    Ashutosh Singh, Anshu Kumar Jha, Bipul Chandra Kalita, Dharmendra Kumar Jha, Yash Alok
    International Journal of Diabetes in Developing Countries.2022; 42(3): 523.     CrossRef
  • miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney
    Dan Gao, Pei Yu, Sanhui Jing, Chengcheng Yan, Dandan Ding, Yingjin Qiao, Ge Wu
    Canadian Journal of Physiology and Pharmacology.2022; 100(1): 26.     CrossRef
  • 3-Hydroxybutyrate Ameliorates the Progression of Diabetic Nephropathy
    Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
    Antioxidants.2022; 11(2): 381.     CrossRef
  • Emerging Role of Epitranscriptomics in Diabetes Mellitus and Its Complications
    Xinqian Geng, Zheng Li, Ying Yang
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Analysis of serum circulating MicroRNAs level in Malaysian patients with gestational diabetes mellitus
    Sajad Jamalpour, Shamsul Mohd Zain, Reza Vazifehmand, Zahurin Mohamed, Yuh Fen Pung, Hesam Kamyab, Siti Zawiah Omar
    Scientific Reports.2022;[Epub]     CrossRef
  • Combined Single-Cell RNA-Seq and Spatial Transcriptomics Reveal an Atlas of Human Diabetic Kidney Disease
    Duo Chen, Mingwei Shao, Yi Song, Gaofei Ren, Feng Guo, Xunjie Fan, Yanyan Wang, Wei Zhang, Guijun Qin
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • How to inhibit transforming growth factor beta safely in diabetic kidney disease
    Yuxin Yang, Kexin Shi, Devang M. Patel, Fang Liu, Tieqiao Wu, Zhonglin Chai
    Current Opinion in Nephrology & Hypertension.2021; 30(1): 115.     CrossRef
  • Plasma miR-193a-3p can be a potential biomarker for the diagnosis of diabetic nephropathy
    Yan Hong, Jidong Wang, Lai Zhang, Wenjuan Sun, Xuefang Xu, Kaiyue Zhang
    Annals of Clinical Biochemistry: International Journal of Laboratory Medicine.2021; 58(2): 141.     CrossRef
  • Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
    Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
    Scientific Reports.2021;[Epub]     CrossRef
  • Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway
    Zhuo Li, Zhiwen Lian, Jianchao Ma, Li Zhang, Xingji Lian, Shuangxin Liu, Jianteng Xie, Zhonglin Feng, Ting Lin, Hong Zhang, Xinling Liang
    Bioengineered.2021; 12(1): 1138.     CrossRef
  • A Nonlinear Relationship Between Serum 25-Hydroxyvitamin D and Urine Albumin to Creatinine Ratio in Type 2 Diabetes: A Cross-Sectional Study in China
    Qian Liang, Haofei Hu, Han Wu, Xuan Chen, Wei Wang, Ying Le, Shufen Yang, Lijing Jia
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 2581.     CrossRef
  • Proteinuria as a significant predictive factor for the progression of carotid artery atherosclerosis in non-albuminuric type 2 diabetes
    Young-eun Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-soo Cha, Byung-Wan Lee
    Diabetes Research and Clinical Practice.2021; 181: 109082.     CrossRef
  • USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells
    Kaipeng Huang, Xilin Zhao
    Experimental Cell Research.2020; 393(2): 112100.     CrossRef
  • D-dimer Levels in Chronic Kidney Illness: A Comprehensive and Systematic Literature Review
    Sahar Vahdat, Shahrzad Shahidi
    Proceedings of the National Academy of Sciences, India Section B: Biological Sciences.2020; 90(5): 911.     CrossRef
  • Circulating Expression Level of LncRNA Malat1 in Diabetic Kidney Disease Patients and Its Clinical Significance
    Lian-ji Zhou, Da-wei Yang, Li-Na Ou, Xing-Rong Guo, Biao-liang Wu
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Impact of chronic kidney disease definition on assessment of its incidence and risk factors in patients with newly diagnosed type 1 and type 2 diabetes in the UK: A cohort study using primary care data from the United Kingdom
    Antonio González-Pérez, Maria E. Saéz, David Vizcaya, Marcus Lind, Luis A. García Rodríguez
    Primary Care Diabetes.2020; 14(4): 381.     CrossRef
  • Resveratrol Inhibits Lipopolysaccharide-Induced Extracellular Matrix Accumulation and Inflammation in Rat Glomerular Mesangial Cells by SphK1/S1P2/NF-κB Pathway


    Wenyan Gong, Jie Li, Wenying Chen, Fuzhen Feng, Yanhui Deng
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 4495.     CrossRef
  • Effects of dietary iron restriction on kidney mitochondria function and oxidative stress in streptozotocin-diabetic rats
    Donovan J. Peña-Montes, Maribel Huerta-Cervantes, Mónica Ríos-Silva, Xóchitl Trujillo, Christian Cortés-Rojo, Miguel Huerta, Alfredo Saavedra-Molina
    Mitochondrion.2020; 54: 41.     CrossRef
  • Significance of glycated LDL in different stages of diabetic nephropathy
    Khalid Siddiqui, Teena P. George, Shaik Sarfaraz Nawaz, Maram Yaslam, Ebtehal Almogbel, Khalid Al-Rubeaan
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 548.     CrossRef
  • Prognostic value of visit-to-visit systolic blood pressure variability related to diabetic kidney disease among patients with type 2 diabetes
    Zhe-Bin Yu, Jian-Bing Wang, Die Li, Xue-Yu Chen, Hong-Bo Lin, Kun Chen
    Journal of Hypertension.2019; 37(7): 1411.     CrossRef
  • Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
    Mitsuo Kato, Rama Natarajan
    Nature Reviews Nephrology.2019; 15(6): 327.     CrossRef
  • Resveratrol inhibits high glucose-induced activation of AP-1 and NF-κB via SphK1/S1P2 pathway to attenuate mesangial cells proliferation and inflammation
    Yanhui Deng, Wenyan Gong, Qiang Li, Xian Wu, Liyao Wu, Xiaoxia Zheng, Wenying Chen, Heqing Huang
    Journal of Functional Foods.2019; 55: 86.     CrossRef
  • Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study
    You-Cheol Hwang, Se Won Kim, Kyu Yeon Hur, Bong-Soo Cha, In Joo Kim, Tae Sun Park, Sei Hyun Baik, Kun Ho Yoon, Kwan Woo Lee, In Kyu Lee, Moon-Kyu Lee
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease in Patients With Type 2 Diabetes
    Hoyoon Lee, Wonwhi Na, Sang Bae Lee, Chul Woo Ahn, Jun Sung Moon, Kyu Chang Won, Sehyun Shin
    Frontiers in Physiology.2019;[Epub]     CrossRef
  • Comparing the Effect of Dipeptidyl-Peptidase 4 Inhibitors and Sulfonylureas on Albuminuria in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Prospective Open-Label Study
    Po-Chung Cheng, Shang-Ren Hsu, Jeng-Fu Kuo, Yun-Chung Cheng, Yu-Hsiu Liu, Shih-Te Tu
    Journal of Clinical Medicine.2019; 8(10): 1715.     CrossRef
  • Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor Agonism in Diabetic Kidney Disease
    Yaeni Kim, Cheol Whee Park
    International Journal of Molecular Sciences.2019; 20(7): 1782.     CrossRef
  • Regulatory T cells in acute and chronic kidney diseases
    Rahul Sharma, Gilbert R. Kinsey
    American Journal of Physiology-Renal Physiology.2018; 314(5): F679.     CrossRef
  • Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat
    Jianan Geng, Xiaoyan Yu, Chunyu Liu, Chengbo Sun, Menghuan Guo, Zhen Li, Yingli Jin, Yinggang Zou, Jinghua Yu
    Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
  • Overview of the burden of illness and the role of once-weekly glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes
    Deborah Hinnen
    Journal of the American Association of Nurse Practitioners.2018; 30(1): S4.     CrossRef
  • Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats
    Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soar
    Journal of Diabetes Research.2018; 2018: 1.     CrossRef
  • Critical Shear Stress is Associated with Diabetic Kidney Disease in Patients with Type 2 Diabetes
    Seung Min Chung, Jung Hyun Oh, Jun Sung Moon, Yu Kyung Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Scientific Reports.2018;[Epub]     CrossRef
  • Losartan Alleviates Renal Fibrosis and Inhibits Endothelial-to-Mesenchymal Transition (EMT) Under High-Fat Diet-Induced Hyperglycemia
    Yufeng Yao, Yong Li, Xiaofei Zeng, Zheng Ye, Xia Li, Lu Zhang
    Frontiers in Pharmacology.2018;[Epub]     CrossRef
  • Association between poor psychosocial conditions and diabetic nephropathy in Japanese type 2 diabetes patients: A cross‐sectional study
    Hiroyo Ninomiya, Naoto Katakami, Taka‐aki Matsuoka, Mitsuyoshi Takahara, Hitoshi Nishizawa, Norikazu Maeda, Michio Otsuki, Akihisa Imagawa, Hiroyasu Iso, Tetsuya Ohira, Iichiro Shimomura
    Journal of Diabetes Investigation.2018; 9(1): 162.     CrossRef
  • Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease
    Neng-jun Lou, Yi-hong Ni, Hong-ying Jia, Jing-ti Deng, Lu Jiang, Feng-jie Zheng, Ai-li Sun
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice
    Shiwei Hu, Jinhui Wang, Jingfeng Wang, Shijie Li, Wei Jiang, Yu Liu
    Journal of Functional Foods.2017; 31: 123.     CrossRef
  • Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
    Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
    Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292.     CrossRef
  • Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence
    Jun-Ya Kaimori, Yoshitaka Isaka, Masaki Hatanaka, Satoko Yamamoto, Naotsugu Ichimaru, Akihiko Fujikawa, Hiroshi Shibata, Akira Fujimori, Sosuke Miyoshi, Takashi Yokawa, Kagayaki Kuroda, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara
    Scientific Reports.2017;[Epub]     CrossRef
  • Rutin suppresses high glucose-induced ACTA2 and p38 protein expression in diabetic nephropathy
    Chun-Shan Han, Kai Liu, Ning Zhang, Shi-Wen Li, Hai-Cheng Gao
    Experimental and Therapeutic Medicine.2017; 14(1): 181.     CrossRef
  • Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption
    Jiani Huang, Wenyan Gong, Zhiquan Chen, Junying Huang, Qiuhong Chen, Heqing Huang, Chunshun Zhao
    European Journal of Pharmaceutical Sciences.2017; 99: 128.     CrossRef
  • New therapeutic agents in diabetic nephropathy
    Yaeni Kim, Cheol Whee Park
    The Korean Journal of Internal Medicine.2017; 32(1): 11.     CrossRef
  • Urine clusterin/apolipoprotein J is linked to tubular damage and renal outcomes in patients with type 2 diabetes mellitus
    Sang Soo Kim, Sang Heon Song, Jong Ho Kim, Yun Kyung Jeon, Bo Hyun Kim, Min‐Cheol Kang, Sung Wan Chun, Soo Hyun Hong, Michelle Chung, Yong Ki Kim, In Joo Kim, Young‐Bum Kim
    Clinical Endocrinology.2017; 87(2): 156.     CrossRef
  • Treatment of diabetic kidney disease: current and future targets
    Mi-Kyung Kim
    The Korean Journal of Internal Medicine.2017; 32(4): 622.     CrossRef
  • Sphingosine kinase 1 mediates AGEs-induced fibronectin upregulation in diabetic nephropathy
    Cheng Chen, Wenyan Gong, Changzheng Li, Fengxiao Xiong, Shaogui Wang, Junying Huang, Yu Wang, Zhiquan Chen, Qiuhong Chen, Peiqing Liu, Tian Lan, Heqing Huang
    Oncotarget.2017; 8(45): 78660.     CrossRef
  • Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes
    Eugene Han, Gyuri Kim, Ji-Yeon Lee, Yong-ho Lee, Beom Seok Kim, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
    Endocrinology and Metabolism.2017; 32(2): 274.     CrossRef
  • Glycemic Management of Patients Undergoing Dialysis
    Mi-Kyung Kim
    The Journal of Korean Diabetes.2016; 17(3): 164.     CrossRef
  • Probucol in Albuminuric Type 2 Diabetes Mellitus Patients on Renin–Angiotensin System Blockade
    Sang-Man Jin, Kyung Ah Han, Jae Myung Yu, Tae Seo Sohn, Sung Hee Choi, Choon Hee Chung, Ie Byung Park, Eun Jung Rhee, Sei Hyun Baik, Tae Sun Park, In-Kyu Lee, Seung-Hyun Ko, You-Cheol Hwang, Bong Soo Cha, Hyoung Woo Lee, Moon-Suk Nam, Moon-Kyu Lee
    Arteriosclerosis, Thrombosis, and Vascular Biology.2016; 36(10): 2108.     CrossRef
  • MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARγ pathway in diabetic nephropathy
    Xiaoyan Hou, Jianwei Tian, Jian Geng, Xiao Li, Xun Tang, Jun Zhang, Xiaoyan Bai
    Oncotarget.2016; 7(30): 47760.     CrossRef
  • Lipoprotein(a) predicts a new onset of chronic kidney disease in people with Type 2 diabetes mellitus
    J.‐S. Yun, Y.‐B. Ahn, K.‐H. Song, K.‐D. Yoo, Y.‐M. Park, H.‐W. Kim, S.‐H. Ko
    Diabetic Medicine.2016; 33(5): 639.     CrossRef
  • Metabolic biomarkers for chronic kidney disease
    Marc Breit, Klaus M. Weinberger
    Archives of Biochemistry and Biophysics.2016; 589: 62.     CrossRef
  • Effect of Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin, on Renal Renin-Angiotensin System in an Animal Model of Type 2 Diabetes
    Seok Joon Shin, Sungjin Chung, Soo Jung Kim, Eun-Mi Lee, Young-Hye Yoo, Ji-Won Kim, Yu-Bae Ahn, Eun-Sook Kim, Sung-Dae Moon, Myung-Jun Kim, Seung-Hyun Ko, Kwang-Hyun Baek
    PLOS ONE.2016; 11(11): e0165703.     CrossRef
  • Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice
    Gwon-Soo Jung, Jae-Han Jeon, Mi Sun Choe, Sung-Woo Kim, In-Kyu Lee, Mi-Kyung Kim, Keun-Gyu Park
    Diabetes & Metabolism Journal.2016; 40(3): 211.     CrossRef
  • Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats
    Liliany S de Brito Amaral, Fernanda A Silva, Vicente B Correia, Clara EF Andrade, Bárbara A Dutra, Márcio V Oliveira, Amélia CM de Magalhães, Rildo A Volpini, Antonio C Seguro, Terezila M Coimbra, Telma de J Soares
    Experimental Biology and Medicine.2016; 241(4): 437.     CrossRef
  • Adenosine monophosphate–activated protein kinase in diabetic nephropathy
    Yaeni Kim, Cheol Whee Park
    Kidney Research and Clinical Practice.2016; 35(2): 69.     CrossRef
  • Estimated Glucose Disposal Rate (eGDR) – A Marker for the Assessment of Insulin Resistance in Type 1 Diabetes Mellitus
    Mihaela L. Bîcu, Daniel Bîcu, Sigina Gârgavu, Magdalena Sandu, Mihaela I. Vladu, Diana Clenciu, Eugen Moţa, Maria Moţa
    Romanian Journal of Diabetes Nutrition and Metabolic Diseases.2016; 23(2): 177.     CrossRef
  • Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway
    Cheng Chen, Kaipeng Huang, Jie Hao, Junying Huang, Zhiying Yang, Fengxiao Xiong, Peiqing Liu, Heqing Huang
    Molecular and Cellular Endocrinology.2016; 427: 45.     CrossRef
  • Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes
    Hye-jin Yoon, Yong-ho Lee, So Ra Kim, Tyler Hyungtaek Rim, Eun Young Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Byung-Wan Lee
    Cardiovascular Diabetology.2015;[Epub]     CrossRef
  • Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptozotocin-Induced Diabetic Rats
    Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen
    Journal of Diabetes Research.2015; 2015: 1.     CrossRef
  • The association between abnormal heart rate variability and new onset of chronic kidney disease in patients with type 2 diabetes: A ten-year follow-up study
    Jae-Seung Yun, Yu-Bae Ahn, Ki-Ho Song, Ki-Dong Yoo, Hyung-Wook Kim, Yong-Moon Park, Seung-Hyun Ko
    Diabetes Research and Clinical Practice.2015; 108(1): 31.     CrossRef
  • Finerenone: third-generation mineralocorticoid receptor antagonist for the treatment of heart failure and diabetic kidney disease
    Licette CY Liu, Elise Schutte, Ron T Gansevoort, Peter van der Meer, Adriaan A Voors
    Expert Opinion on Investigational Drugs.2015; 24(8): 1123.     CrossRef
  • Effects of pentoxifylline on proteinuria and glucose control in patients with type 2 diabetes: a prospective randomized double-blind multicenter study
    Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Seung Soo Sheen, Choon Hee Chung, Chul Woo Ahn, Se Hwa Kim, Yong-Wook Cho, Seok Won Park, Soo-Kyung Kim, Chul Sik Kim, Kyung Wook Kim, Kwan Woo Lee
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Proteomic Profile in Glomeruli of Type-2 Diabetic KKAy Mice using 2-Dimensional Differential Gel Electrophoresis
    Lining Wang
    Medical Science Monitor.2014; 20: 2705.     CrossRef
Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy
Sungjin Chung, Cheol Whee Park
Diabetes Metab J. 2011;35(4):327-336.   Published online August 31, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.4.327
  • 65,535 View
  • 47 Download
  • 16 Crossref
AbstractAbstract PDFPubReader   

With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process. Peroxisome proliferator-activated receptor alpha (PPARα) agonists have been used primarily in clinical practice for the treatment of dyslipidemia and insulin resistance. Given that PPARα expression and regulation of metabolic pathways are involved in oxidative stress, inflammation, blood pressure regulation, and the renin-angiotensin aldosterone system, PPARα likely influences the development and pathogenesis of diabetic nephropathy via indirect effects on glucose and lipid homeostasis and also by direct action on the kidneys. These findings suggest that PPARα may become an important therapeutic target for treating diabetic renal complications.

Citations

Citations to this article as recorded by  
  • The Proteome of Circulating Large Extracellular Vesicles in Diabetes and Hypertension
    Akram Abolbaghaei, Maddison Turner, Jean-François Thibodeau, Chet E. Holterman, Christopher R. J. Kennedy, Dylan Burger
    International Journal of Molecular Sciences.2023; 24(5): 4930.     CrossRef
  • Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway
    Laongdao Thongnak, Nattavadee Pengrattanachot, Sasivimon Promsan, Nichakorn Phengpol, Prempree Sutthasupha, Krit Jaikumkao, Anusorn Lungkaphin
    Archives of Pharmacal Research.2023; 46(5): 408.     CrossRef
  • A comprehensive insight into the molecular and cellular mechanisms of the effects of Propolis on preserving renal function: a systematic review
    Paniz Anvarifard, Maryam Anbari, Alireza Ostadrahimi, Mohammadreza Ardalan, Zohreh Ghoreishi
    Nutrition & Metabolism.2022;[Epub]     CrossRef
  • APX-115, a pan-NADPH oxidase inhibitor, protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice
    Eun Soo Lee, Hong Min Kim, Sun Hee Lee, Kyung Bong Ha, Yoon Soo Bae, Soo Jin Lee, Sung Hwan Moon, Eun Young Lee, Ji-Hye Lee, Choon Hee Chung
    Free Radical Biology and Medicine.2020; 161: 92.     CrossRef
  • Fenofibrate decreased microalbuminuria in the type 2 diabetes patients with hypertriglyceridemia
    Xiaomeng Sun, Jia Liu, Guang Wang
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • AMPK allostery: A therapeutic target for the management/treatment of diabetic nephropathy
    Kehinde Sulaimon Ayinde, Olamide Tosin Olaoba, Boyenle Ibrahim, Du Lei, Qian Lu, Xiaoxing Yin, Temitope Isaac Adelusi
    Life Sciences.2020; 261: 118455.     CrossRef
  • Greater efficacy of atorvastatin versus a non-statin lipid-lowering agent against renal injury: potential role as a histone deacetylase inhibitor
    Ravi Shankar Singh, Dharmendra Kumar Chaudhary, Aradhana Mohan, Praveen Kumar, Chandra Prakash Chaturvedi, Carolyn M. Ecelbarger, Madan M. Godbole, Swasti Tiwari
    Scientific Reports.2016;[Epub]     CrossRef
  • Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury
    Yong Yang, Ting Bai, You-Li Yao, De-Quan Zhang, Yan-Ling Wu, Li-Hua Lian, Ji-Xing Nan
    Toxicology Letters.2016; 262: 80.     CrossRef
  • Peroxisome proliferator-activated receptor α-dependent renoprotection of murine kidney by irbesartan
    Makoto Harada, Yuji Kamijo, Takero Nakajima, Koji Hashimoto, Yosuke Yamada, Hisashi Shimojo, Frank J. Gonzalez, Toshifumi Aoyama
    Clinical Science.2016; 130(21): 1969.     CrossRef
  • Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice
    Eun Sil Koh, Ji Hee Lim, Min Young Kim, Sungjin Chung, Seok Joon Shin, Bum Soon Choi, Hye Won Kim, Seong Yeon Hwang, Sae Woong Kim, Cheol Whee Park, Yoon Sik Chang
    Journal of Translational Medicine.2015;[Epub]     CrossRef
  • Diabetic Kidney Disease: From Epidemiology to Clinical Perspectives
    Cheol Whee Park
    Diabetes & Metabolism Journal.2014; 38(4): 252.     CrossRef
  • Peroxisome proliferator-activated receptor agonists in a battle against the aging kidney
    Marijn M. Speeckaert, Céline Vanfraechem, Reinhart Speeckaert, Joris R. Delanghe
    Ageing Research Reviews.2014; 14: 1.     CrossRef
  • Fenofibrate and dipyridamole treatments in low-doses either alone or in combination blunted the development of nephropathy in diabetic rats
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    Pharmacological Research.2014; 90: 36.     CrossRef
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Peroxisome Proliferator-activated Receptors (PPARs) in Diabetic Nephropathy.
Cheol Whee Park
Korean Diabetes J. 2004;28(3):149-159.   Published online June 1, 2004
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Diabetes Metab J : Diabetes & Metabolism Journal