Diabetes & Metabolism Journal

Original Article

Pharmacotherapy
Efficacy and Safety of HD-6277, a Novel G Protein-Coupled Receptor 40 Agonist, in Individuals with Type 2 Diabetes Mellitus: A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 2 Clinical Trial: Yong-ho Lee, Kyung Wan Min, Jun Hwa Hong, Soo Lim, Jae Myung Yu, Choon Hee Chung, Jun Sung Moon, Jong Chul Won, Chul Woo Ahn, Jie-Eun Lee, Tae Nyun Kim, Byung-Wan Lee; Diabetes Metab J. 2026;50(3):576-586. Published online December 19, 2025; DOI: https://doi.org/10.4093/dmj.2025.0528

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Background
This study assessed the efficacy and safety of HD-6277, a novel oral G protein-coupled receptor 40 (GPR40) agonist in adults with inadequate control of type 2 diabetes mellitus (T2DM).
Methods
This double-blind, randomized, placebo-controlled phase 2 trial recruited 112 individuals aged 18–75 years with T2DM and glycosylated hemoglobin (HbA1c) levels between 7.0% and 10.0% while on diet and exercise alone for at least 8 weeks before screening. Parallel-group randomized trials of HD-6277 (50 and 100 mg groups vs. placebo) were conducted for 12 weeks. The primary outcome was the change in HbA1c levels from baseline to week 12. Secondary outcomes included changes in HbA1c, fasting plasma glucose (FPG), postprandial glucose, insulin, glycoalbumin, and C-peptide at weeks 4, 8, and 12.
Results
At week 12, HD-6277 at 50 and 100 mg demonstrated statistically significant reductions in HbA1c compared to placebo, with least square (LS) mean differences of –0.73% (95% confidence interval [CI], –1.11 to –0.35; P=0.0002) and –0.85% (95% CI, –1.21 to –0.50; P<0.0001), respectively. Both doses also produced clinically meaningful reductions in FPG. Additionally, HD- 6277 at 100 mg significantly increased the insulinogenic index compared to placebo, with an LS mean difference of 1.91 (95% CI, 0.34 to 3.48; P=0.0175). No clinically relevant treatment-related adverse events were observed.
Conclusion
HD-6277 at 50 and 100 mg improved glycemic control and was well-tolerated in adults with T2DM inadequately managed with diet and exercise. GPR40 agonists may offer a promising new therapeutic option for T2DM.

Citations

Citations to this article as recorded by

Revisiting GPR40 Agonist in Type 2 Diabetes Mellitus: A Cautious but Meaningful Return
Eun-Hee Cho
Diabetes & Metabolism Journal.2026; 50(3): 472. CrossRef

Review

Guideline/Statement/Fact Sheet
Bridging Evidence and Practice: A Consensus Statement from the Korean Diabetes Association on Diabetes Screening, Pharmacological Treatment and Severe Diabetes: Jong Han Choi, Shinae Kang, Soo-Kyung Kim, Won Jun Kim, Ji Min Kim, Jaehyun Bae, Jae-Seung Yun, Eonju Jeon, Young-Eun Kim, Jae Hyun Bae, Hun Jee Choe, Young Min Cho, Seung-Hyun Ko, Sang Yong Kim, Hae Jin Kim, You-Cheol Hwang, Min Kyong Moon, Suk Chon, Seon Mee Kang, Hyuk-Sang Kwon, Mi Kyung Kim, You-Bin Lee, Se Hee Min, Jung Hwan Park, Woo Je Lee, Bong-Soo Cha, Byung-Wan Lee; Diabetes Metab J. 2025;49(6):1155-1177. Published online November 1, 2025; DOI: https://doi.org/10.4093/dmj.2025.0978

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This Korean Diabetes Association (KDA) consensus statement bridges global evidence with the Korean clinical context, where large randomized and real-world data remain limited. Recommendations required ≥80% agreement by the committee of clinical practice guideline and approval by the board of directors. The statement comprises three domains: diabetes screening aligned with Korean epidemiology; pharmacologic management guided by pathophysiology and comorbidities; and a severity construct of “severe diabetes mellitus” that links complication-based staging with metabolic grading to match therapeutic intensity to disease complexity. Compared with prior KDA guidelines, this statement introduces substantive advances in three areas. First, screening recommendations are streamlined to emphasize risk-aligned, practical implementation rather than prescriptive test sequences. Second, pharmacologic management applies an individualized framework for drug selection that jointly considers pathophysiology and comorbidities. It operationalizes individualized selection by dominant pathophysiology (insulin resistance vs. insulin insufficiency) and coexisting conditions, and formalizes treatment dynamics—early combination, timely initiation of injectables, avoidance of overbasalization, and structured deintensification. It also prioritizes agents with proven cardiovascular and renal protection and elevates management of obesity and metabolic dysfunction-associated steatotic liver disease as central goals; clinically, insulin should be initiated promptly in hypercatabolic states or suspected islet failure, and technology-enabled care—including continuous glucose monitoring and automated insulin delivery—are integral across all stages. Third, the newly introduced severity construct underpins treatment-intensity decisions across domains without reiterating prescriptive algorithms. Collectively, these recommendations provide a coherent, context-appropriate framework for diabetes screening and management in Korea and identify priorities for future evidence generation.

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Original Article

Guideline/Statement/Fact Sheet
2025 Clinical Practice Guidelines for Diabetes Management in Korea: Recommendation of the Korean Diabetes Association: Shinae Kang, Seon Mee Kang, Jong Han Choi, Seung-Hyun Ko, Bo Kyung Koo, Hyuk-Sang Kwon, Mi Kyung Kim, Sang Yong Kim, Soo-Kyung Kim, Young-eun Kim, Eun Sook Kim, Jae Hyeon Kim, Chong Hwa Kim, Ji Min Kim, Hae Jin Kim, Min Kyong Moon, Sun Joon Moon, Jun Sung Moon, Joon Ho Moon, Se Hee Min, Jung Hwan Park, Jaehyun Bae, Keeho Song, Ji Yoon Ahn, Jae-Seung Yun, Woo Je Lee, You-Bin Lee, Suk Chon, Eonju Jeon, Sang-Man Jin, Eugene Han, You-Cheol Hwang, Jae Hyun Bae, YoonJu Song, Jeong Hyun Lim, Jae Won Cho, Ji Yeon Choi, Yong Hee Hong, Jieun Lee, Sung Eun Kim, Ji Yun Noh, Bong-Soo Cha, Byung-Wan Lee; Diabetes Metab J. 2025;49(4):582-783. Published online July 1, 2025; DOI: https://doi.org/10.4093/dmj.2025.0469

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Review

Guideline/Fact Sheet
Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Review and Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association: Jaehyun Bae, Eugene Han, Hye Won Lee, Cheol-Young Park, Choon Hee Chung, Dae Ho Lee, Eun-Hee Cho, Eun-Jung Rhee, Ji Hee Yu, Ji Hyun Park, Ji-Cheol Bae, Jung Hwan Park, Kyung Mook Choi, Kyung-Soo Kim, Mi Hae Seo, Minyoung Lee, Nan-Hee Kim, So Hun Kim, Won-Young Lee, Woo Je Lee, Yeon-Kyung Choi, Yong-ho Lee, You-Cheol Hwang, Young Sang Lyu, Byung-Wan Lee, Bong-Soo Cha, on Behalf of the Fatty Liver Research Group of the Korean Diabetes Association; Diabetes Metab J. 2024;48(6):1015-1028. Published online November 1, 2024; DOI: https://doi.org/10.4093/dmj.2024.0541

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Since the role of the liver in metabolic dysfunction, including type 2 diabetes mellitus, was demonstrated, studies on non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) have shown associations between fatty liver disease and other metabolic diseases. Unlike the exclusionary diagnostic criteria of NAFLD, MAFLD diagnosis is based on the presence of metabolic dysregulation in fatty liver disease. Renaming NAFLD as MAFLD also introduced simpler diagnostic criteria. In 2023, a new nomenclature, steatotic liver disease (SLD), was proposed. Similar to MAFLD, SLD diagnosis is based on the presence of hepatic steatosis with at least one cardiometabolic dysfunction. SLD is categorized into metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-related/-associated liver disease, alcoholrelated liver disease, specific etiology SLD, and cryptogenic SLD. The term MASLD has been adopted by a number of leading national and international societies due to its concise diagnostic criteria, exclusion of other concomitant liver diseases, and lack of stigmatizing terms. This article reviews the diagnostic criteria, clinical relevance, and differences among NAFLD, MAFLD, and MASLD from a diabetologist’s perspective and provides a rationale for adopting SLD/MASLD in the Fatty Liver Research Group of the Korean Diabetes Association.

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Original Articles

Guideline/Fact Sheet
2023 Clinical Practice Guidelines for Diabetes Management in Korea: Full Version Recommendation of the Korean Diabetes Association: Jun Sung Moon, Shinae Kang, Jong Han Choi, Kyung Ae Lee, Joon Ho Moon, Suk Chon, Dae Jung Kim, Hyun Jin Kim, Ji A Seo, Mee Kyoung Kim, Jeong Hyun Lim, Yoon Ju Song, Ye Seul Yang, Jae Hyeon Kim, You-Bin Lee, Junghyun Noh, Kyu Yeon Hur, Jong Suk Park, Sang Youl Rhee, Hae Jin Kim, Hyun Min Kim, Jung Hae Ko, Nam Hoon Kim, Chong Hwa Kim, Jeeyun Ahn, Tae Jung Oh, Soo-Kyung Kim, Jaehyun Kim, Eugene Han, Sang-Man Jin, Jaehyun Bae, Eonju Jeon, Ji Min Kim, Seon Mee Kang, Jung Hwan Park, Jae-Seung Yun, Bong-Soo Cha, Min Kyong Moon, Byung-Wan Lee; Diabetes Metab J. 2024;48(4):546-708. Published online July 26, 2024; DOI: https://doi.org/10.4093/dmj.2024.0249

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Drug/Regimen
Real-World Prescription Patterns and Barriers Related to the Use of Sodium-Glucose Cotransporter 2 Inhibitors among Korean Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: Jong Ha Baek, Ye Seul Yang, Seung-Hyun Ko, Kyung Do Han, Jae Hyeon Kim, Min Kyong Moon, Jong Suk Park, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Jong Han Choi, Kyu Yeon Hur, Committee of Clinical Practice Guidelines, Korean Diabetes Association; Diabetes Metab J. 2022;46(5):701-712. Published online June 3, 2022; DOI: https://doi.org/10.4093/dmj.2022.0002

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Background
To evaluate prescription trends and clinical factors of the sodium-glucose cotransporter 2 inhibitors (SGLT2i) use according to the presence of atherosclerotic cardiovascular disease (ASCVD) or heart failure (HF) in Korean patients with type 2 diabetes mellitus (T2DM).
Methods
Prescription patterns of SGLT2i use between 2015 and 2019 were determined using the Korean National Health Insurance Service database of claims.
Results
Of all patients with T2DM (n=4,736,493), the annual prescription rate of SGLT2i increased every year in patients with ASCVD (from 2.2% to 10.7%) or HF (from 2.0% to 11.1%). After the first hospitalization for ASCVD (n=518,572), 13.7% (n=71,259) of patients initiated SGLT2i with a median of 10.6 months. After hospitalization for HF (n=372,853), 11.2% (n=41,717) of patients initiated SGLT2i after a median of 8.8 months. In multivariate regression for hospitalization, older age (per 10 years, odds ratio [OR], 0.57; 95% confidence interval [CI], 0.56 to 0.57), lower household income (OR, 0.93; 95% CI, 0.92 to 0.95), rural residents (OR, 0.95; 95% CI, 0.93 to 0.97), and dipeptidyl peptidase-4 inhibitor (DPP-4i) users (OR, 0.82; 95% CI, 0.81 to 0.84) were associated with lesser initiation of SGLT2i in ASCVD. Additionally, female gender (OR, 0.97; 95% CI, 0.95 to 0.99) was associated with lesser initiation of SGLT2i in HF.
Conclusion
The prescription rate of SGLT2i increased gradually up to 2019 but was suboptimal in patients with ASCVD or HF. After the first hospitalization for ASCVD or HF, older age, female gender, low household income, rural residents, and DPP-4i users were less likely to initiate SGLT2i.

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Review

Guideline/Fact Sheet
2021 Clinical Practice Guidelines for Diabetes Mellitus in Korea: Kyu Yeon Hur, Min Kyong Moon, Jong Suk Park, Soo-Kyung Kim, Seung-Hwan Lee, Jae-Seung Yun, Jong Ha Baek, Junghyun Noh, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Ye Seul Yang, Jang Won Son, Jong Han Choi, Kee Ho Song, Nam Hoon Kim, Sang Yong Kim, Jin Wha Kim, Sang Youl Rhee, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim, Chong Hwa Kim, Dae Jung Kim, SungWan Chun, Eun-Jung Rhee, Hyun Min Kim, Hyun Jung Kim, Donghyun Jee, Jae Hyun Kim, Won Seok Choi, Eun-Young Lee, Kun-Ho Yoon, Seung-Hyun Ko, Committee of Clinical Practice Guidelines, Korean Diabetes Association; Diabetes Metab J. 2021;45(4):461-481. Published online July 30, 2021; DOI: https://doi.org/10.4093/dmj.2021.0156

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The Committee of Clinical Practice Guidelines of the Korean Diabetes Association (KDA) updated the previous clinical practice guidelines for Korean adults with diabetes and prediabetes and published the seventh edition in May 2021. We performed a comprehensive systematic review of recent clinical trials and evidence that could be applicable in real-world practice and suitable for the Korean population. The guideline is provided for all healthcare providers including physicians, diabetes experts, and certified diabetes educators across the country who manage patients with diabetes or the individuals at the risk of developing diabetes mellitus. The recommendations for screening diabetes and glucose-lowering agents have been revised and updated. New sections for continuous glucose monitoring, insulin pump use, and non-alcoholic fatty liver disease in patients with diabetes mellitus have been added. The KDA recommends active vaccination for coronavirus disease 2019 in patients with diabetes during the pandemic. An abridgement that contains practical information for patient education and systematic management in the clinic was published separately.

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Lipid Management in Korean People with Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
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Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Study
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Analysis of the Incidence of Type 2 Diabetes, Requirement of Insulin Treatment, and Diabetes-Related Complications among Patients with Cancer
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젊은 2형 당뇨병 환자의 관리
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Original Articles

Complications
Renal Tubular Damage Marker, Urinary N-acetyl-β-D-Glucosaminidase, as a Predictive Marker of Hepatic Fibrosis in Type 2 Diabetes Mellitus: Hae Kyung Kim, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee; Diabetes Metab J. 2022;46(1):104-116. Published online July 13, 2021; DOI: https://doi.org/10.4093/dmj.2020.0273

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Background
Non-alcoholic steatohepatitis is closely associated with the progression of diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM). We investigated whether urinary N-acetyl-β-D-glucosaminidase (u-NAG), an early renal tubular damage biomarker in DKD, could be related to the degree of hepatic fibrosis in patients with T2DM.
Methods
A total of 300 patients with T2DM were enrolled in this study. Hepatic steatosis and fibrosis were determined using transient elastography. The levels of urinary biomarkers, including u-NAG, albumin, protein, and creatinine, and glucometabolic parameters were measured.
Results
Based on the median value of the u-NAG to creatinine ratio (u-NCR), subjects were divided into low and high u-NCR groups. The high u-NCR group showed a significantly longer duration of diabetes, worsened hyperglycemia, and a more enhanced hepatic fibrosis index. A higher u-NCR was associated with a greater odds ratio for the risk of higher hepatic fibrosis stage (F2: odds ratio, 1.99; 95% confidence interval [CI], 1.04 to 3.82). Also, u-NCR was an independent predictive marker for more advanced hepatic fibrosis, even after adjusting for several confounding factors (β=1.58, P<0.01).
Conclusion
The elevation of u-NAG was independently associated with a higher degree of hepatic fibrosis in patients with T2DM. Considering the common metabolic milieu of renal and hepatic fibrosis in T2DM, the potential use of u-NAG as an effective urinary biomarker reflecting hepatic fibrosis in T2DM needs to be validated in the future.

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Basic Research
Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway: Ji-Yeon Lee, Minyoung Lee, Ji Young Lee, Jaehyun Bae, Eugene Shin, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha; Diabetes Metab J. 2021;45(6):921-932. Published online February 22, 2021; DOI: https://doi.org/10.4093/dmj.2020.0187

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Background
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a new class of antidiabetic drugs that exhibit multiple extraglycemic effects. However, there are conflicting results regarding the effects of SGLT2 inhibition on energy expenditure and thermogenesis. Therefore, we investigated the effect of ipragliflozin (a selective SGLT2 inhibitor) on energy metabolism.
Methods
Six-week-old male 129S6/Sv mice with a high propensity for adipose tissue browning were randomly assigned to three groups: normal chow control, 60% high-fat diet (HFD)-fed control, and 60% HFD-fed ipragliflozin-treated groups. The administration of diet and medication was continued for 16 weeks.
Results
The HFD-fed mice became obese and developed hepatic steatosis and adipose tissue hypertrophy, but their random glucose levels were within the normal ranges; these features are similar to the metabolic features of a prediabetic condition. Ipragliflozin treatment markedly attenuated HFD-induced hepatic steatosis and reduced the size of hypertrophied adipocytes to that of smaller adipocytes. In the ipragliflozin treatment group, uncoupling protein 1 (Ucp1) and other thermogenesis-related genes were significantly upregulated in the visceral and subcutaneous adipose tissue, and fatty acid oxidation was increased in the brown adipose tissue. These effects were associated with a significant reduction in the insulin-to-glucagon ratio and the activation of the AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1) pathway in the liver and adipose tissue.
Conclusion
SGLT2 inhibition by ipragliflozin showed beneficial metabolic effects in 129S6/Sv mice with HFD-induced obesity that mimics prediabetic conditions. Our data suggest that SGLT2 inhibitors, through their upregulation of energy expenditure, may have therapeutic potential in prediabetic obesity.

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Technology/Device
Data Configuration and Publication Trends for the Korean National Health Insurance and Health Insurance Review & Assessment Database: Hae Kyung Kim, Sun Ok Song, Junghyun Noh, In-Kyung Jeong, Byung-Wan Lee; Diabetes Metab J. 2020;44(5):671-678. Published online October 21, 2020; DOI: https://doi.org/10.4093/dmj.2020.0207

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Abstract PDF PubReader ePub

Background
Big data reports related to diseases and health care for the Korean population have been published since the National Health Insurance Service (NHIS) and the Health Insurance Review & Assessment (HIRA) Service provided limited open access to their databases. Here, we reviewed the structure, content, and means of using data from the National Health Insurance (NHI) system for the benefit of Korean researchers and presented the latest publication trends in Korean healthcare data procured from the NHI and HIRA databases.
Methods
Since 2013, researchers have been able to obtain nationwide population-based studies using the NHI and HIRA databases of the insured. We searched publications using the NHI and the HIRA databases between 2013 and 2019 retrieved from PubMed.
Results
The NHI and HIRA databases provide nationwide population-based data. The total number of publications from 2014 to 2019 using NHI and HIRA databases is 2,541 and 655, respectively. A total of 5,465 endocrinology-related studies were performed during 2014 to 2019.
Conclusion
The NHIS and HIRA databases have provided tools for guidelines to approach world-leading population-based epidemiology and disease research.

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Taehee Chang, Jinah Park, Whanhee Lee, Sung-mok Jung, Kyung-Duk Min, Ho Kim, Sung-il Cho, Seoyeong Ahn, Yoonhee Kim
Public Health.2026; 253: 106189. CrossRef
Psychiatric, Cardiovascular and Skeletal Risks of Codeine versus Oxycodone in Hip Osteoarthritis: A Population-Based Cohort Study
Jeongmin Lee, Yujin Kim, Eunjung Choo, Sooyoung Shin, Yeo Jin Choi
Drug Design, Development and Therapy.2026; Volume 20: 1. CrossRef
Longitudinal changes in cardiorespiratory fitness and risk of depressive and anxiety disorders in a nationwide cohort of 7 million participants
Jin-Hyun Park, Seokjin Kong, Yohwan Lim, Yunhwan Oh, Porwarat Chawanid, Batuhan Gökbulut, Ju-Wan Kim, Sun Jae Park, Hye Jun Kim, Sangwook Cheon, Eun Seok Kang, Seohui Jang, Jeongin Lee, Minjeong Kang, Taeho Kwak, Yihyun Kim, Jihun Song, Jaewon Khil, Su Ky
Scientific Reports.2026;[Epub] CrossRef
Estimation of healthy worker survivor bias among middle-aged populations in Korea
Byungyoon Yun, Beom Kyung Kim, Sung-In Jang, Laura S Rozek, Heejin Kimm, Juyeon Oh, Jin-Ha Yoon
International Journal of Epidemiology.2026;[Epub] CrossRef
Risk of Liver and Kidney Adverse Events After Androgen Deprivation Therapy in Prostate Cancer: A Population-Based Retrospective Cohort Study
Jiwoo Yun, Ah-Young Kim, Il-Hyung Hwang, Sukhyang Lee, Hankil Lee
Journal of Urologic Oncology.2026; 24(1): 21. CrossRef
Alcohol-driven phenotypic transition in MASLD and risk of liver-related events
Seohui Jang, Jihun Song, Eun Seok Kang, Sangwook Cheon, Taeho Kwak, Yihyun Kim, Seokjin Kong, Jinhyeok Choi, Minjeong Kang, Jaewon Khil, Hye Jun Kim, Jeongin Lee, Hwamin Lee, Seogsong Jeong
JHEP Reports.2026; 8(7): 101866. CrossRef
Asthma prevalence and risk factors in early-onset atopic dermatitis using Korean National Health Insurance Service data
Jiwon Kim, Minyoung Jung, Ji Young Lee, Yechan Kyung, Kwanghoon Kim, Hoseob Kim, Mina Kim, Minji Kim
Scientific Reports.2026;[Epub] CrossRef
Comparative risk of psychiatric comorbidities associated with codeine and tramadol in patients with hip osteoarthritis: a nationwide population-based cohort study
Yujin Kim, Eunjung Choo, Sooyoung Shin, Yeo Jin Choi
Journal of Global Health.2026;[Epub] CrossRef
2025 Obesity Fact Sheet for Korea: Prevalence of Obesity, Abdominal Obesity from 2014 to 2023 and Prevalence of Chronic Disease by Obesity Status
Esther Kim, Sinyoung Cho, Jiyoung Kim, Bongseong Kim, Ho-tak Seo, Ga Eun Nam, In Young Cho, Kye-Yeung Park, Su-Min Jeong, Kyungdo Han
Journal of Obesity & Metabolic Syndrome.2026; 35(2): 176. CrossRef
Association between steatotic liver disease subtype and thyroid cancer in women: A nationwide population-based cohort study
Hyunju Park, Arim Choi, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim
Frontiers in Endocrinology.2026;[Epub] CrossRef
Primary cardiovascular preventive effect of thiazolidinedione in adults with type 2 diabetes: A nationwide cohort study in Korea
Yun Young Choi, Jimin Jeon, Minyoul Baik, Joonsang Yoo, Jinkwon Kim
Journal of Diabetes Investigation.2026; 17(8): 1367. CrossRef
Comparison of Palliative Care Access Between Patients With Liver Cirrhosis and Hepatocellular Carcinoma: Nationwide Population-Based Study
Jung Sil Jang, Si Nae Oh, Haeyong Pak
Journal of Korean Medical Science.2026;[Epub] CrossRef
Clinical implications of delayed insertion of implantable loop recorder: Is it still beneficial when inserted years after a stroke?
Hye Bin Gwag, Nak Gyeong Ko, Mihyeon Jin
Journal of the Neurological Sciences.2026; 488: 126051. CrossRef
Noncombustible Nicotine or Tobacco Product Use After Smoking Cessation and Major Vision-Impairing Diseases: A Nationwide Cohort Study
SANGWOOK CHEON, YIHYUN KIM, EUN SEOK KANG, HWAMIN LEE, SEOGSONG JEONG
American Journal of Ophthalmology.2026; 290: 36. CrossRef
Association of Sodium‐Glucose Cotransporter‐2 Inhibitors With Incident Gout Risk: A Population‐Based Comparative Cohort Study With Genetic Evidence From Mendelian Randomisation
Hong Sang Choi, Jaejun Heo, Sungho Won, Sang Heon Suh, Chang Seong Kim, Eun Hui Bae, Juhee Ahn, Soo Wan Kim
Diabetes, Obesity and Metabolism.2026; 28(9): 8230. CrossRef
Operational Definitions of Population, Intervention, Comparison, Outcome for Generating Real-World Evidence Using Korean Health Insurance Claims Sample Data in Integrative Medicine Research: A Methodological Guide
Haein Kim, Seungwon Shin
Perspectives on Integrative Medicine.2026; 5(2): 73. CrossRef
Development and Temporal Validation of Machine Learning Models for Hyponatremia Risk in Community-Dwelling Older Adults: A Nationwide Claims-Based Study
Hee-Jae Lee, Kwanghee Jun
Journal of Clinical Medicine.2026; 15(13): 5072. CrossRef
Inverse association between metabolic dysfunction-associated steatotic liver disease and incident rheumatoid arthritis in middle-aged adults with chronic hepatitis B
Junwon Park, Eun Seok Kang, Seogsong Jeong
Clinical Rheumatology.2026;[Epub] CrossRef
Income level and the risk of incident dementia among adults aged ≥50 with newly diagnosed type 2 diabetes: a population-based cohort study using the NHIS-Senior database in South Korea
Su-Min Park, Ah Jung Ko, Jae Hyeok Lim, Eun-Cheol Park
BMJ Open.2026; 16(7): e112641. CrossRef
Risk Factors for Coronary Heart Disease and Stroke Among Older Adults With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Nationwide Cohort Study
Sangwook Cheon, Seohui Jang, Eun Seok Kang, Jihun Song, Jaewon Khil, Seokjin Kong, Yihyun Kim, Jin Hyun Park, Minjeong Kang, Jeongin Lee, Taeho Kwak, Hye Jun Kim, Jinhyeok Choi, Hwamin Lee, Seogsong Jeong
Journal of the American Heart Association.2026;[Epub] CrossRef
Cost-Effectiveness of Biportal Endoscopic Spine Surgery Compared with Microscopic Surgery for Lumbar Degenerative Diseases: A Pooled Analysis of Two Randomized Controlled Trials
Sang-Min Park, Kwang-Sup Song, Ho-Joong Kim, Min-Seok Kang, Ki-Han You, Jin-Sung Kim, Hyun-Jin Park
The Spine Journal.2026;[Epub] CrossRef
NMR-Based Metabolic Profiling of Biobank Derived Blood Samples for the Identification of Liver Disease Biomarkers
Munki Choo, Chaeyoung Lee, Sunghyouk Park, Hyuk Nam Kwon
Biomolecules & Therapeutics.2026; 34(4): 922. CrossRef
Treatment gaps in osteoporosis care following recurrent fractures: a nationwide cohort study
Hyun Jin Han, Miryoung Kim, Eyoung Wang, Min Ji Kim, Hae Sun Suh
Journal of Comparative Effectiveness Research.2026;[Epub] CrossRef
Patients with Psoriatic Arthritis Have Increased Dental Comorbidities: A Nationwide Population-based Cohort Study in Korea
Seokjin Kong, Ko Eun Kim, Eun-Jung Kwak, Han-Na Kim, Anna Kim, Jiehyun Jeon, Chan Mi Park, Yoo Sang Baek
Acta Dermato-Venereologica.2026;[Epub] CrossRef
Incidence of systemic vasculitides after Mycobacterium tuberculosis infection: a population-based cohort study in Korea
Minkyung Han, Jang Woo Ha, Inkyung Jung, Chi Young Kim, Sung Soo Ahn
Rheumatology.2025; 64(3): 1400. CrossRef
Dementia Incidence in Survivors of Multiple Myeloma: A National Case-Control Study Conducted in Korea (The CAREMM-2106 Study)
Jeonghoon Ha, Suein Choi, Seulji Moon, Jinseon Han, Jeongyoon Lee, Sung-Soo Park, Sheng-Min Wang, Seunghoon Han, Chang-Ki Min
Clinical Lymphoma Myeloma and Leukemia.2025; 25(1): e40. CrossRef
Autophagy activation in response to cigarette smoke: Exploring the disparity in laryngeal cancer incidence and outcomes between sexes in South Korea
Min Ji Kim, Jisu Hong, Hyo Won Chang, Yun-Hee Lee, Jun-Pyo Myong, Ah Ra Jung, Yoon Se Lee, Minsu Kwon
Translational Oncology.2025; 52: 102229. CrossRef
Big Data Research for Diabetes-Related Diseases Using the Korean National Health Information Database
Kyung-Soo Kim, Bongseong Kim, Kyungdo Han
Diabetes & Metabolism Journal.2025; 49(1): 13. CrossRef
The impact of the COVID-19 pandemic on clinical practices related to colorectal cancer and colonoscopy in South Korea: a nationwide population-based study
Jin Young Yoon, Moon Hyung Lee, Min Seob Kwak, Jae Myung Cha
Intestinal Research.2025; 23(1): 85. CrossRef
Facilitators and Barriers to Multidisciplinary Teamwork in Adolescent and Young Adult Oncology Care: A Descriptive Qualitative Study
Hyewon Shin, Jin Young Seo, Eun Seok Choi, Jennie De Gagne
Journal of Multidisciplinary Healthcare.2025; Volume 18: 917. CrossRef
Differential Pattern of Symptom Correlation With Acute Respiratory Infections in Korea
Jinsoo Kim, Gyoohwan Jung, Soyeoun Kim
Pediatric Infectious Disease Journal.2025; 44(7): 609. CrossRef
The Impact of COVID-19 on Admissions and In-hospital Mortality of Patients With Stroke in Korea: An Interrupted Time Series Analysis
Youngs Chang, Soo-Hee Hwang, Haibin Bai, Seowoo Park, Eunbyul Cho, Dohoung Kim, Hyejin Lee, Jin Yong Lee
Journal of Preventive Medicine and Public Health.2025; 58(1): 60. CrossRef
Impact of COVID-19 on admission and in-hospital mortality of patients with acute myocardial infarction in Korea: An interrupted time series analysis
Soo-Hee Hwang, Youngs Chang, Haibin Bai, Jieun Yun, Hyejin Lee, Jin Yong Lee, Dong Keon Yon
PLOS ONE.2025; 20(2): e0316943. CrossRef
Risk of cardiovascular diseases and gastrointestinal bleeding is comparable between celecoxib and non-selective non-steroidal anti-inflammatory drugs in patients with ankylosing spondylitis: a nationwide retrospective cohort study
A Kim, SC Kim, J Kim, MW So, S-G Lee
Scandinavian Journal of Rheumatology.2025; 54(3): 204. CrossRef
Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study
Han Na Jung, Ji Hye Heo, Eun Roh, Kyung‐Do Han, Jun Goo Kang, Seong Jin Lee, Sung‐Hee Ihm
Journal of Hepato-Biliary-Pancreatic Sciences.2025; 32(7): 514. CrossRef
Double disparities of the excess risks and costs of extreme temperatures on hospitalization between Medical Aid and non-Medical Aid populations in South Korea
Ayoung Kim, Jinah Park, Cinoo Kang, Ho Kim, Whanhee Lee
International Journal of Epidemiology.2025;[Epub] CrossRef
Longitudinal association between consecutive moderate-to-vigorous physical activity and the risk of depression among depressed and non-depressed participants: A nationally representative cohort study
Yohwan Lim
Journal of Affective Disorders.2025; 381: 475. CrossRef
Risk of Gout Among Patients With Tuberculosis: A Nationwide Cohort Study in South Korea
Chi Young Kim, Jang Woo Ha, Inkyung Jung, Minkyung Han, Sung Soo Ahn
International Journal of Rheumatic Diseases.2025;[Epub] CrossRef
Association of Metabolic Dysfunction‐Associated Steatotic Liver Disease With Sudden Sensorineural Hearing Loss Among Older Adults
Eun Seok Kang, Seohui Jang, Hye Jun Kim, Kyuwoong Kim, Meng Sha, Yun Hwan Oh, Michelle J. Suh, Seogsong Jeong
Laryngoscope Investigative Otolaryngology.2025;[Epub] CrossRef
Association between temporomandibular disorders and mental and behavioural disorders - a nationwide population-based cross-sectional study
Younjung Park, Sora Yoon, Joon-Ho Yoon, Jin-Joo Yoo
Clinical Oral Investigations.2025;[Epub] CrossRef
Intellectual developmental disability and all-cause and cause-specific mortality among individuals with type 2 diabetes mellitus
Jun-Hyuk Lee, Yong-Moon Mark Park, Kyungdo Han, Ye-Bin Park, Bong-Seong Kim, Jin-Hyung Jung, Ga Eun Nam
Diabetes Research and Clinical Practice.2025; 226: 112305. CrossRef
The Effectiveness of Operative Fixation for Comminuted Distal Radial Fractures in the Hyper-aged Patients Over 75 Years Old in South Korea
Jisu PARK, Jaemin LEE, Jin Rok OH
The Journal of Hand Surgery (Asian-Pacific Volume).2025; 30(03): 271. CrossRef
Association between osteoporosis and mortality in Parkinson's disease with mediating effect of hip fractures: a Korean nationwide population-based study
Yeonju Jin, Bo Kyu Choi, Jong Woo Lee, Jin Yong Hong, Ickpyo Hong, Min Seok Baek
Frontiers in Aging Neuroscience.2025;[Epub] CrossRef
Association between inhaled corticosteroids and incidence of idiopathic pulmonary fibrosis: nationwide population-based study
Hyewon Lee, Hee-Young Yoon
BMJ Open Respiratory Research.2025; 12(1): e002566. CrossRef
Prescribing Patterns of SGLT2 Inhibitors and GLP‐1 Receptor Agonists in Patients With T2DM and ASCVD in South Korea
Yeong Rok Eom, Hajung Joo, Seung Eun Chae, Nam Kyung Je
Pharmacoepidemiology and Drug Safety.2025;[Epub] CrossRef
Risk of pancreatic cancer according to glycemic status in nonalcoholic fatty liver disease: a nationwide cohort study
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Scientific Reports.2025;[Epub] CrossRef
Older Age Threshold for Oxaliplatin Benefit in Stage II to III Colorectal Cancer
Jun Woo Bong, Hwamin Lee, Seogsong Jeong, Sanghee Kang
JAMA Network Open.2025; 8(8): e2525660. CrossRef
Fractures incidence and its association on mortality in multiple myeloma patients: a nationwide cohort study (CAREMM-2105 study)
Jeonghoon Ha, Suein Choi, Sung-Soo Park, Seulji Moon, Jinseon Han, Jeongyoon Lee, Ki-Hyun Baek, Seunghoon Han, Chang-Ki Min
Scientific Reports.2025;[Epub] CrossRef
Patterns of spinal injections following lumbar fusion surgery: a nationwide cohort study with 3-year follow-up
Yong Jae Na, Beom Suk Kim, Woo-Keun Kwon
European Spine Journal.2025; 34(9): 4205. CrossRef
Real-World Utilization Patterns of Immune Checkpoint Inhibitors Based on the National Health Insurance Service Data in Korea
Eunji Kim, Yu-Seon Jung, Jongmin Lee, Dal Ri Nam, Seung-Hun You, Ju Won Lee, Sook Ryun Park, Ji Seon Oh, Ye-Jee Kim, Eun-Jung Jo, Nakyung Jeon, Won-Jung Jung, Sun-Young Jung
Clinical Therapeutics.2025; 47(10): 837. CrossRef
Overall survival following radical surgery and postoperative chemotherapy in colorectal cancer patients aged ≥ 70 years: a population-based retrospective cohort study
Ji-Yeon Mun, Kyungdo Han, Nina Yoo, Bong-Hyeon Kye, InKyu Lee
BMC Cancer.2025;[Epub] CrossRef
Real-world evidence on the additional cancer risk reduction of ezetimibe: a 10-year nationwide retrospective cohort study emulating a target trial
Yohwan Lim, Eunji Kim, Eunjung Hwang, Koanhoi Kim, Yonghae Son, Sang Yeoup Lee, Young Hye Cho, Eun-Ju Park, Youngin Lee, Sae Rom Lee, Jung-In Choi, Han-Sol Jeong, Su-Jung Park, Soo Min Son, Ryuk Jun Kwon
Journal of Cancer Research and Clinical Oncology.2025;[Epub] CrossRef
Latent tuberculosis infection screening in patients with inflammatory bowel disease: a nationwide retrospective cohort study in South Korea comparing IGRA alone versus a combination of TST and IGRA
Ye-Jee Kim, Jiyeon Kim, Jiwon Lee, Tae Sun Shim, Sang Hyoung Park, Kyung-Wook Jo
Intestinal Research.2025; 23(4): 541. CrossRef
Triglyceride-glucose index variability and risk of all-cause and cardiovascular mortality
Jimin Park, Duk Ho Kim, Jun-Hyuk Lee
Scientific Reports.2025;[Epub] CrossRef
Metabolic Dysfunction-Associated Steatotic Liver Disease and Risk of Hepatocellular Carcinoma in Type 2 Diabetes Mellitus
So Hyun Cho, Gyuri Kim, Kyu-na Lee, Rosa Oh, Ji Yoon Kim, Myunghwa Jang, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
Diabetes & Metabolism Journal.2025; 49(6): 1298. CrossRef
Dementia in older adults with schizophrenia: a 12-year analysis of prevalence, incidence, and treatment patterns in South Korea
Jung Su Park, Sangwan Kim, Donghoon Jeong, Jeong Pil Choi, Hyunsu Jeong, Alan Jung Park, Yong Sik Kim, Joongyub Lee, Se Hyun Kim
Schizophrenia.2025;[Epub] CrossRef
Nationwide health claims analysis of phenothiazine‐associated retinopathy risk in chlorpromazine and perphenazine users
Jiyeong Kim, Jee-Eun Chung, Seong Joon Ahn
Scientific Reports.2025;[Epub] CrossRef
Impact of Type 2 Diabetes Mellitus on Age at Death in the Hemodialysis Population: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018
Ji Hong You, Kang Ju Son, Kyoung Sook Park, Byung-Wan Lee, Sun Ok Song
Diabetology.2025; 6(12): 145. CrossRef
Epidemiology and sociodemographic determinants of chronic temporomandibular disorders in South Korea: a nationwide population-based study
Younjung Park, Sora Yoon, Joon-Ho Yoon, Jin-Joo Yoo
BMC Oral Health.2025;[Epub] CrossRef
Comparative Cardiovascular Safety of Duloxetine and Gabapentin in Patients with Hip Osteoarthritis
Suhyeon Moon, Eunjung Choo, Yeo Jin Choi, Sooyoung Shin
Journal of Pain Research.2025; Volume 18: 6437. CrossRef
The delayed cancer treatment and economic inequality in Korea: results of common cancers by the time-to-surgery
Noorhee Son, Woo-Ri Lee, Dong-Woo Choi, Kyu-Tae Han
Epidemiology and Health.2025; 47: e2025056. CrossRef
Data profile: cancer sample cohorts (stomach, breast, colorectal, and liver) in Korea
Daewoo Pak, Suk Yong Jang, Jin-Ha Yoon, Dong Wook Kim, Jin-Won Noh, Dong-Woo Choi, Minyeong Guk, Hyeri Kim, Ju-Won Oh, Heejung Chae, Hyun-Joo Kong, Gi Hyun Kim, Ji Woong Nam, Ga Ram Lee, Dayun Park, Jehoo Jeon, Byungyoon Yun, Ki-Bong Yoo, Kui Son Choi
Epidemiology and Health.2025; 47: e2025058. CrossRef
Various Antihypertensive Drug Compliance Models and Cardiovascular Prognosis of People With Incidentally Detected High Blood Pressure During Health Check‐Up in Korea
Jong-Kwan Park, Sungyoun Chun, Joongmin Kim, Hancheol Lee, Ji-Yong Jang, Kyeong-Hyeon Chun, Hyeongsoo Kim, Seung-Jin Oh, Geunhee Park, Se-Jung Yoon, Peng Geng
International Journal of Hypertension.2025;[Epub] CrossRef
Medical service utilization patterns among adults with insomnia: A retrospective cohort study
Min Kyung Hyun, Jang Won Lee
European Journal of Integrative Medicine.2024; 67: 102325. CrossRef
COVID-19-related cardiovascular disease risk due to weight gain: a nationwide cohort study
Su Kyoung Lee, Yohwan Lim, Seogsong Jeong, Hyun Wook Han
European Journal of Medical Research.2024;[Epub] CrossRef
Kidney Health Plan 2033 in Korea: bridging the gap between the present and the future
Do Hyoung Kim, Young Youl Hyun, Jin Joo Cha, Sua Lee, Hyun Kyung Lee, Jong Wook Choi, Su-Hyun Kim, Sang Youb Han, Cheol Whee Park, Eun Young Lee, Dae Ryong Cha, Sung Gyun Kim, Chun Soo Lim, Sun-Hee Park
Kidney Research and Clinical Practice.2024; 43(1): 8. CrossRef
Bipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea
You-Bin Lee, Hyewon Kim, Jungkuk Lee, Dongwoo Kang, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim, Hong Jin Jeon, Kyu Yeon Hur
Scientific Reports.2024;[Epub] CrossRef
Evidence for the biopsychosocial model of suicide: a review of whole person modeling studies using machine learning
Earvin S. Tio, Melissa C. Misztal, Daniel Felsky
Frontiers in Psychiatry.2024;[Epub] CrossRef
Nationwide Study of the Epidemiology, Diagnosis, and Treatment of Hypersensitivity Pneumonitis in Korea
Hae In Jung, Dal Ri Nam, Seung-Hun You, Jae-Woo Jung, Kang-Mo Gu, Sun-Young Jung
Journal of Korean Medical Science.2024;[Epub] CrossRef
Quantitative risk factor analysis of prior disease condition and socioeconomic status with the multiple myeloma development: nationwide cohort study
Suein Choi, Eunjin Kim, Jinhee Jung, Sung-Soo Park, Chang-Ki Min, Seunghoon Han
Scientific Reports.2024;[Epub] CrossRef
Association of physical activity with fractures in kidney transplant recipients: A Korean nationwide cohort study
Sungmi Kim, Jin‐Hyung Jung, Kyungho Lee, Junseok Jeon, Dong Wook Shin, Hye Ryoun Jang, Jung Eun Lee, Kyungdo Han, Wooseong Huh
Clinical Transplantation.2024;[Epub] CrossRef
Impact of an expanded reimbursement policy on utilization of implantable loop recorders in patients with cryptogenic stroke in Korea
Hye Bin Gwag, Nak Gyeong Ko, Mihyeon Jin
The Korean Journal of Internal Medicine.2024; 39(3): 469. CrossRef
Smoking status and clinical outcome in idiopathic pulmonary fibrosis: a nationwide study
Hee-Young Yoon, Hoseob Kim, Yoonjong Bae, Jin Woo Song
Respiratory Research.2024;[Epub] CrossRef
Data Resource Profile: Health Insurance Review and Assessment Service Covid-19 Observational Medical Outcomes Partnership (HIRA Covid-19 OMOP) database in South Korea
Chungsoo Kim, Dong Han Yu, Hyeran Baek, Jaehyeong Cho, Seng Chan You, Rae Woong Park
International Journal of Epidemiology.2024;[Epub] CrossRef
Drug Persistence and Incidence of Active Tuberculosis of Tumor Necrosis Factor Alpha Inhibitors Versus Tocilizumab as the First-Line Biological Treatment in Patients with Rheumatoid Arthritis: A Nationwide Population-Based Retrospective Cohort Analysis
Min Wook So, A-Ran Kim, Seung-Geun Lee
Rheumatology and Therapy.2024; 11(4): 881. CrossRef
Body mass index is associated with clinical outcomes in idiopathic pulmonary fibrosis
Hee-Young Yoon, Hoseob Kim, Yoonjong Bae, Jin Woo Song
Scientific Reports.2024;[Epub] CrossRef
DA-9601 has protective effects comparable to those of proton pump inhibitor and rebamipide against nonsteroidal anti-inflammatory drugs-induced upper and lower gastrointestinal bleeding in patients with rheumatoid arthritis: A nationwide study using Korea
Min Wook So, Aran Kim, Seung-Geun Lee
Medicine.2024; 103(27): e38801. CrossRef
Prescription patterns and effectiveness of medications for chronic obstructive pulmonary disease: A retrospective study of real-world settings
Hye Jung Park, Jae Uk Lee, Soyoung Jeon, Hye Sun Lee, Bo Yeon Kim, Yu Jin Chae, Gui Ok Kim, Jung-Won Park, Jae-Hyun Lee, Ai Theng Cheong
PLOS ONE.2024; 19(6): e0304362. CrossRef
High remnant-cholesterol levels increase the risk for end-stage renal disease: a nationwide, population-based, cohort study
Han Na Jung, Ji Hye Huh, Eun Roh, Kyung-Do Han, Jun Goo Kang, Seong Jin Lee, Sung-Hee Ihm
Lipids in Health and Disease.2024;[Epub] CrossRef
Major cardiovascular events in long-term multiple myeloma survivors: a Korean case–control study (the CAREMM-2105 study)
Jeonghoon Ha, Suein Choi, Seulji Moon, Jinseon Han, Jeongyoon Lee, Ki-Hyun Baek, Seunghoon Han, Sung-Soo Park, Chang-Ki Min
Clinical and Experimental Medicine.2024;[Epub] CrossRef
Association between exercise habits and incident type 2 diabetes mellitus in patients with thyroid cancer: nationwide population-based study
Jiyun Park, Jin-Hyung Jung, Hyunju Park, Young Shin Song, Soo-Kyung Kim, Yong-Wook Cho, Kyungdo Han, Kyung-Soo Kim
BMC Medicine.2024;[Epub] CrossRef
Big Data Research on Severe Asthma
Sang Hyuk Kim, Youlim Kim
Tuberculosis and Respiratory Diseases.2024; 87(3): 213. CrossRef
Detecting spatial heat vulnerability in the city considering spatiotemporal population distribution: A focus on the elderly during daytime
Seunghyun Lee, Jae Seung Lee, Saehoon Kim
Urban Climate.2024; 56: 102054. CrossRef
Real‐World Incidence of Incident Noninfectious Uveitis in Patients Treated With BRAF Inhibitors: A Nationwide Clinical Cohort Study
HYUNJEAN JUNG, SUNYEUP KIM, CHRISTOPHER SEUNGKYU LEE, SUK HO BYEON, SUNG SOO KIM, SEUNG WON LEE, YONG JOON KIM
American Journal of Ophthalmology.2024; 267: 142. CrossRef
Incidence of hearing loss following COVID-19 among young adults in South Korea: a nationwide cohort study
Hye Jun Kim, Seogsong Jeong, Kyuwoong Kim, Joon Don Lee, Yun Hwan Oh, Michelle J. Suh
eClinicalMedicine.2024; 75: 102759. CrossRef
Comparative risk of serious infections and tuberculosis in Korean patients with inflammatory bowel disease treated with non-anti-TNF biologics or anti-TNF-α agents: a nationwide population-based cohort study
Min Jee Kim, Ye-Jee Kim, Daehyun Jeong, Seonok Kim, Seokchan Hong, Sang Hyoung Park, Kyung-Wook Jo
Therapeutic Advances in Gastroenterology.2024;[Epub] CrossRef
Cancer risk among air transportation industry workers in Korea: a national health registry-based study
Soojin Park, Ga Bin Lee, Dalnim Lee, Eun-Shil Cha, Kyunghee Han, Minsu Cho, Songwon Seo
BMC Public Health.2024;[Epub] CrossRef
The Impact of Infectious Mononucleosis History on the Risk of Developing Lymphoma and Nasopharyngeal Carcinoma: A Retrospective Large-Scale Cohort Study Using National Health Insurance Data in South Korea
So Hee Kang, Yun-Hee Lee, Jun-Pyo Myong, Minsu Kwon
Cancer Research and Treatment.2024; 56(4): 1077. CrossRef
Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study
Si Nae Oh, Hye Jun Kim, Jae Yong Shim, Kyuwoong Kim, Seogsong Jeong, Sun Jae Park, Sang Hyun Lee, Joong Won Ha, Sang Min Park
Scientific Reports.2024;[Epub] CrossRef
Impact of mental disorders on the all-cause mortality and cardiovascular disease outcomes in adults with new-onset type 1 diabetes: A nationwide cohort study
Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
Psychiatry Research.2024; 342: 116228. CrossRef
Nationwide study of chronic codeine use and its impact on cough related diseases in South Korea
Tai Joon An, Yun-Hee Lee, Joon-Sung Joh, Jun-Pyo Myong
Scientific Reports.2024;[Epub] CrossRef
Association of age at menopause and suicide risk in postmenopausal women: a nationwide cohort study
Daa Un Moon, Hyewon Kim, Jin-Hyung Jung, Kyungdo Han, Hong Jin Jeon
Frontiers in Psychiatry.2024;[Epub] CrossRef
Does endometriosis increase the risks of endometrial hyperplasia and endometrial cancer?
Hoon Kim, Hyun Jung Kim, Hyeong Sik Ahn
Gynecologic Oncology.2023; 169: 147. CrossRef
Cardiovascular Outcomes according to Comorbidities and Low-Density Lipoprotein Cholesterol in Korean People with Type 2 Diabetes Mellitus
Min Kyong Moon, Junghyun Noh, Eun-Jung Rhee, Sang Hyun Park, Hyeon Chang Kim, Byung Jin Kim, Hae Jin Kim, Seonghoon Choi, Jin Oh Na, Young Youl Hyun, Bum Joon Kim, Kyung-Do Han, In-Kyung Jeong
Diabetes & Metabolism Journal.2023; 47(1): 45. CrossRef
Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Study
Junghyun Noh, Min Kyong Moon, Eun-Jung Rhee, Sang Hyun Park, Hyeon Chang Kim, Byung Jin Kim, Hae Jin Kim, Seonghoon Choi, Jin Oh Na, Young Youl Hyun, Bum Joon Kim, Kyung-Do Han, In-Kyung Jeong
Diabetes & Metabolism Journal.2023; 47(1): 59. CrossRef
Predicting the Risk of Insulin-Requiring Gestational Diabetes before Pregnancy: A Model Generated from a Nationwide Population-Based Cohort Study in Korea
Seung-Hwan Lee, Jin Yu, Kyungdo Han, Seung Woo Lee, Sang Youn You, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
Endocrinology and Metabolism.2023; 38(1): 129. CrossRef
Genital tract infection and pelvic surgery contribute to the development of endometriosis
Ae Ra Han, Suehyun Lee, Jaehun Cha, Jong-Yeup Kim, Dong-Kyu Kim, Jae Won Han, Chul Jung Kim, Sung Ki Lee
Journal of Reproductive Immunology.2023; 156: 103831. CrossRef
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Type 1 Diabetes
Age at Diagnosis and the Risk of Diabetic Nephropathy in Young Patients with Type 1 Diabetes Mellitus: Jong Ha Baek, Woo Je Lee, Byung-Wan Lee, Soo Kyoung Kim, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim; Diabetes Metab J. 2021;45(1):46-54. Published online July 10, 2020; DOI: https://doi.org/10.4093/dmj.2019.0134

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Background

The aim of this study was to evaluate characteristics and risk of diabetic complications according to age at diagnosis among young adults with type 1 diabetes mellitus (T1DM).

Methods

A total of 255 T1DM patients aged less than 40 years were included. Patients were categorized into three groups (<20, 20 to 29, and 30 to 40 years) according to age at diagnosis. Diabetic nephropathy (DN) was defined when spot urine-albumin creatinine ratio was 300 mg/g or more and/or estimated glomerular filtration ratio (eGFR) level was 60 mL/min/1.73 m² or less.

Results

Median age at diagnosis was 25 years and disease duration was 14 years. Individuals diagnosed with T1DM at childhood/adolescent (age <20 years) had lower stimulated C-peptide levels. They received more intensive insulin treatment with higher total daily insulin doses compared to older onset groups. The prevalence of DN was higher in the childhood/adolescent-onset group than in older onset groups (25.3% vs. 15.3% vs. 9.6%, P=0.022). The eGFR was inversely associated with disease duration whilst the degree of decrease was more prominent in the childhood/adolescent-onset group than in the later onset group (aged 30 to 40 years; P<0.001). Childhood/adolescent-onset group was independently associated with the risk of DN compared to the older onset group (aged 30 to 40 years; odds ratio, 3.47; 95% confidence interval, 1.45 to 8.33; P=0.005).

Conclusion

In individuals with childhood/adolescent-onset T1DM, the reduction in renal function is more prominent with disease duration. Early age-onset T1DM is an independent risk of DN.

Citations

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Drug/Regimen
Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study: Seung-Hwan Lee, Kyung-Wan Min, Byung-Wan Lee, In-Kyung Jeong, Soon-Jib Yoo, Hyuk-Sang Kwon, Yoon-Hee Choi, Kun-Ho Yoon; Diabetes Metab J. 2021;45(3):339-348. Published online May 28, 2020; DOI: https://doi.org/10.4093/dmj.2019.0203

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Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background

Glycemic variability is associated with the development of diabetic complications and hypoglycemia. However, the effect of sodium-glucose transporter 2 (SGLT2) inhibitors on glycemic variability is controversial. We aimed to examine the effect of dapagliflozin as an add-on therapy to insulin on the glycemic variability assessed using continuous glucose monitoring (CGM) in subjects with type 2 diabetes mellitus.

Methods

In this multicenter, placebo-controlled, double-blind, randomized study, 84 subjects received 10 mg of dapagliflozin (n=41) or the placebo (n=43) for 12 weeks. CGM was performed before and after treatment to compare the changes in glycemic variability measures (standard deviation [SD], mean amplitude of glycemic excursions [MAGEs]).

Results

At week 12, significant reductions in glycosylated hemoglobin (−0.74%±0.66% vs. 0.01%±0.65%, P<0.001), glycated albumin (−3.94%±2.55% vs. −0.67%±2.48%, P<0.001), and CGM-derived mean glucose (−41.6±39.2 mg/dL vs. 1.1±46.2 mg/dL, P<0.001) levels were observed in the dapagliflozin group compared with the placebo group. SD and MAGE were significantly decreased in the dapagliflozin group, but not in the placebo group. However, the difference in ΔSD and ΔMAGE failed to reach statistical significance between two groups. No significant differences in the incidence of safety endpoints were observed between the two groups.

Conclusion

Dapagliflozin effectively decreased glucose levels, but not glucose variability, after 12 weeks of treatment in participants with type 2 diabetes mellitus receiving insulin treatment. The role of SGLT2 inhibitors in glycemic variability warrants further investigations.

Citations

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Review

Guideline/Fact Sheet
Non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association: Byung-Wan Lee, Yong-ho Lee, Cheol-Young Park, Eun-Jung Rhee, Won-Young Lee, Nan-Hee Kim, Kyung Mook Choi, Keun-Gyu Park, Yeon-Kyung Choi, Bong-Soo Cha, Dae Ho Lee, Korean Diabetes Association (KDA) Fatty Liver Research Group; Diabetes Metab J. 2020;44(3):382-401. Published online May 11, 2020; DOI: https://doi.org/10.4093/dmj.2020.0010

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This clinical practice position statement, a product of the Fatty Liver Research Group of the Korean Diabetes Association, proposes recommendations for the diagnosis, progression and/or severity assessment, management, and follow-up of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NAFLD have an increased risk of non-alcoholic steatohepatitis (NASH) and fibrosis and a higher risk of cardiovascular diseases and diabetic complications compared to those without NAFLD. With regards to the evaluation of patients with T2DM and NAFLD, ultrasonography-based stepwise approaches using noninvasive biomarker models such as fibrosis-4 or the NAFLD fibrosis score as well as imaging studies such as vibration-controlled transient elastography with controlled attenuation parameter or magnetic resonance imaging-proton density fat fraction are recommended. After the diagnosis of NAFLD, the stage of fibrosis needs to be assessed appropriately. For management, weight reduction achieved by lifestyle modification has proven beneficial and is recommended in combination with antidiabetic agent(s). Evidence that some antidiabetic agents improve NAFLD/NASH with fibrosis in patients with T2DM is emerging. However, there are currently no definite pharmacologic treatments for NAFLD in patients with T2DM. For specific cases, bariatric surgery may be an option if indicated.

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Corrigendum

Corrigenda: Table Correction. Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis: Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee; Diabetes Metab J. 2019;43(5):731-731. Published online October 24, 2019; DOI: https://doi.org/10.4093/dmj.2019.0188; Corrects: Diabetes Metab J 2019;43(1):31

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Original Article

Clinical Diabetes & Therapeutics
Effectiveness and Safety of Adding Basal Insulin Glargine in Patients with Type 2 Diabetes Mellitus Exhibiting Inadequate Response to Metformin and DPP-4 Inhibitors with or without Sulfonylurea: Yu Mi Kang, Chang Hee Jung, Seung-Hwan Lee, Sang-Wook Kim, Kee-Ho Song, Sin Gon Kim, Jae Hyeon Kim, Young Min Cho, Tae Sun Park, Bon Jeong Ku, Gwanpyo Koh, Dol Mi Kim, Byung-Wan Lee, Joong-Yeol Park; Diabetes Metab J. 2019;43(4):432-446. Published online June 19, 2019; DOI: https://doi.org/10.4093/dmj.2018.0092

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Background

We aimed to investigate the effectiveness and safety of adding basal insulin to initiating dipeptidyl peptidase-4 (DPP-4) inhibitor and metformin and/or sulfonylurea (SU) in achieving the target glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM).

Methods

This was a single-arm, multicenter, 24-week, open-label, phase 4 study in patients with inadequately controlled (HbA1c ≥7.5%) T2DM despite the use of DPP-4 inhibitor and metformin. A total of 108 patients received insulin glargine while continuing oral antidiabetic drugs (OADs). The primary efficacy endpoint was the percentage of subjects achieving HbA1c ≤7.0%. Other glycemic profiles were also evaluated, and the safety endpoints were adverse events (AEs) and hypoglycemia.

Results

The median HbA1c at baseline (8.9%; range, 7.5% to 11.1%) decreased to 7.6% (5.5% to 11.7%) at 24 weeks. Overall, 31.7% subjects (n=33) achieved the target HbA1c level of ≤7.0%. The mean differences in body weight and fasting plasma glucose were 1.2±3.4 kg and 56.0±49.8 mg/dL, respectively. Hypoglycemia was reported in 36 subjects (33.3%, 112 episodes), all of which were fully recovered. There was no serious AE attributed to insulin glargine. Body weight change was significantly different between SU users and nonusers (1.5±2.5 kg vs. −0.9±6.0 kg, P=0.011).

Conclusion

The combination add-on therapy of insulin glargine, on metformin and DPP-4 inhibitors with or without SU was safe and efficient in reducing HbA1c levels and thus, is a preferable option in managing T2DM patients exhibiting dysglycemia despite the use of OADs.

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Short Communication

Clinical Diabetes & Therapeutics
A Lower Baseline Urinary Glucose Excretion Predicts a Better Response to the Sodium Glucose Cotransporter 2 Inhibitor: You-Cheol Hwang, Jae Hyeon Kim, Byung-Wan Lee, Woo Je Lee; Diabetes Metab J. 2019;43(6):898-905. Published online June 14, 2019; DOI: https://doi.org/10.4093/dmj.2018.0257

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We aimed to identify the clinical variables associated with a better glucose-lowering response to the sodium glucose cotransporter 2 inhibitor ipragliflozin in people with type 2 diabetes mellitus (T2DM). We especially focused on urinary glucose excretion (UGE). This was a single-arm multicenter prospective study. A total of 92 people with T2DM aged 20 to 70 years with glycosylated hemoglobin (HbA1c) levels ≥7.0% and ≤9.5% were enrolled. Ipragliflozin (50 mg) was added to the background therapy for these people for 12 weeks. After 3 months treatment with ipragliflozin, the mean HbA1c levels were decreased from 7.6% to 6.9% and 62.0% of the people reached the HbA1c target of less than 7.0% (P<0.001). In addition, body weight, blood pressure, and lipid parameters were improved after ipragliflozin treatment (all P<0.001). The baseline HbA1c (r=0.66, P<0.001) and morning spot urine glucose to creatinine ratio (r=−0.30, P=0.001) were independently associated with the HbA1c reduction. Ipragliflozin treatment for 12 weeks improves glycemic control and other metabolic parameters. A higher HbA1c and lower UGE at baseline predicts a better glucose-lowering efficacy of ipragliflozin.

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Review

Clinical Diabetes & Therapeutics
Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment: Kyung-Soo Kim, Byung-Wan Lee, Yong Jin Kim, Dae Ho Lee, Bong-Soo Cha, Cheol-Young Park; Diabetes Metab J. 2019;43(2):127-143. Published online April 15, 2019; DOI: https://doi.org/10.4093/dmj.2019.0034

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Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders that are often comorbid conditions. Among many proposed treatments, weight reduction is the only approved option for NAFLD to date. However, it is not easy to maintain weight loss by lifestyle modification alone; pharmacological treatments are helpful in this regard. Although many drugs have been investigated, pioglitazone could be a first-line therapy in patients with NAFLD and diabetes. Many more drugs are currently being developed and investigated, and it is likely that combination strategies will be used for future treatment of NAFLD and diabetes. Attention should be paid to the management of NAFLD and diabetes and efforts should be made to intervene early and individualize treatment of NAFLD in patients with diabetes.

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Original Articles

Metabolic Risk/Epidemiology
Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus: Hokyou Lee, Gyuri Kim, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh; Diabetes Metab J. 2020;44(2):267-276. Published online February 28, 2019; DOI: https://doi.org/10.4093/dmj.2019.0001

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Background

Impaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM). However, it is unclear whether NAFLD fibrotic progression, i.e., non-alcoholic steatohepatitis, poses an independent risk for diastolic dysfunction in T2DM. We investigated the association between liver fibrosis and left ventricular (LV) diastolic dysfunction in T2DM.

Methods

We analyzed 606 patients with T2DM, aged ≥50 years, who had undergone liver ultrasonography and pulsed-wave Doppler echocardiography. Insulin sensitivity was measured by short insulin tolerance test. Presence of NAFLD and/or advanced liver fibrosis was determined by abdominal ultrasonography and NAFLD fibrosis score (NFS). LV diastolic dysfunction was defined according to transmitral peak early to late ventricular filling (E/A) ratio and deceleration time, using echocardiography.

Results

LV diastolic dysfunction was significantly more prevalent in the NAFLD versus non-NAFLD group (59.7% vs. 49.0%, P=0.011). When NAFLD was stratified by NFS, subjects with advanced liver fibrosis exhibited a higher prevalence of diastolic dysfunction (49.0%, 50.7%, 61.8%; none, simple steatosis, advanced fibrosis, respectively; P for trend=0.003). In multivariable logistic regression, liver fibrosis was independently associated with diastolic dysfunction (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.07 to 2.34; P=0.022) after adjusting for insulin resistance and cardiometabolic risk factors. This association remained significant in patients without insulin resistance (OR, 4.32; 95% CI, 1.73 to 11.51; P=0.002).

Conclusions

Liver fibrosis was associated with LV diastolic dysfunction in patients with T2DM and may be an independent risk factor for diastolic dysfunction, especially in patients without systemic insulin resistance.

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Clinical Diabetes & Therapeutics
Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors: Ji-Yeon Lee, Yongin Cho, Minyoung Lee, You Jin Kim, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang; Diabetes Metab J. 2019;43(2):158-173. Published online January 25, 2019; DOI: https://doi.org/10.4093/dmj.2018.0057

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Background

We investigated the predictive markers for the therapeutic efficacy and the best combination of sodium-glucose co-transporter 2 (SGLT2) inhibitors (empagliflozin, dapagliflozin, and ipragliflozin) therapy in patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 804 patients with T2DM who had taken SGLT2 inhibitor as monotherapy or an add-on therapy were analyzed. Multivariate regression analyses were performed to identify the predictors of SGLT2 inhibitor response including the classes of baseline anti-diabetic medications.

Results

After adjusting for age, sex, baseline body mass index (BMI), diabetes duration, duration of SGLT2 inhibitor use, initial glycosylated hemoglobin (HbA1c) level, estimated glomerular filtration rate (eGFR), and other anti-diabetic agent usage, multivariate analysis revealed that shorter diabetes duration, higher initial HbA1c and eGFR were associated with better glycemic response. However, baseline BMI was inversely correlated with glycemic status; lean subjects with well-controlled diabetes and obese subjects with inadequately controlled diabetes received more benefit from SGLT2 inhibitor treatment. In addition, dipeptidyl peptidase 4 (DPP4) inhibitor use was related to a greater reduction in HbA1c in patients with higher baseline HbA1c ≥7%. Sulfonylurea users experienced a larger change from baseline HbA1c but the significance was lost after adjustment for covariates and metformin and thiazolidinedione use did not affect the glycemic outcome.

Conclusion

A better response to SGLT2 inhibitors is expected in Korean T2DM patients who have higher baseline HbA1c and eGFR with a shorter diabetes duration. Moreover, the add-on of an SGLT2 inhibitor to a DPP4 inhibitor is likely to show the greatest glycemic response.

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Communications Medicine.2026;[Epub] CrossRef
Comparative Clinical Analysis of DPP-4 inhibitors and SGLT2 Inhibitors: A Real-World Switch Study
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Daniele Scoccimarro, Giacomo Cipani, Ilaria Dicembrini, Edoardo Mannucci
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M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini, Federica Ginestra, Gloria Formoso, Agostino Consoli, Francesco Andreozzi, Giorgio Sesti, Salvatore Turco, Luigi Lucibelli, Adriano Gatti, Raffaella
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Seung-Hwan Lee, Kyung-Wan Min, Byung-Wan Lee, In-Kyung Jeong, Soon-Jib Yoo, Hyuk-Sang Kwon, Yoon-Hee Choi, Kun-Ho Yoon
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Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice
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Tae Jung Oh, Ju-Young Moon, Kyu Yeon Hur, Seung Hyun Ko, Hyun Jung Kim, Taehee Kim, Dong Won Lee, Min Kyong Moon
Diabetes & Metabolism Journal.2020; 44(4): 489. CrossRef
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Francesco Giorgino, Irene Caruso, Julia Moellmann, Michael Lehrke
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Clinical Predictors of the Hypoglycemic Effect of Sodium–Glucose Co-transporter-2 Inhibitors in Hyperuricemic Patients: A Retrospective Descriptive Observational Study
Toshinori Hirai, Yuya Kawagoe, Motoki Kei, Ryuichi Ogawa, Toshimasa Itoh
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Sodium-glucose cotransporter-2 inhibitor for renal function preservation in patients with type 2 diabetes mellitus: A Korean Diabetes Association and Korean Society of Nephrology consensus statement
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Kidney Research and Clinical Practice.2020; 39(3): 269. CrossRef
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Ildiko Lingvay, Matthew S Capehorn, Andrei-Mircea Catarig, Pierre Johansen, Jack Lawson, Anna Sandberg, Robert Shaw, Abby Paine
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Letter: Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors (Diabetes Metab J 2019;43:158–73)
Kyung-Soo Kim
Diabetes & Metabolism Journal.2019; 43(3): 377. CrossRef
Response: Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors (Diabetes Metab J 2019;43:158–73)
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Clinical Diabetes & Therapeutics
Acarbose Add-on Therapy in Patients with Type 2 Diabetes Mellitus with Metformin and Sitagliptin Failure: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study: Hae Kyung Yang, Seung-Hwan Lee, Juyoung Shin, Yoon-Hee Choi, Yu-Bae Ahn, Byung-Wan Lee, Eun Jung Rhee, Kyung Wan Min, Kun-Ho Yoon; Diabetes Metab J. 2019;43(3):287-301. Published online December 20, 2018; DOI: https://doi.org/10.4093/dmj.2018.0054

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Background

We evaluated the efficacy and safety of acarbose add-on therapy in Korean patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled with metformin and sitagliptin.

Methods

A total of 165 subjects were randomized to metformin and sitagliptin (Met+Sita, n=65), metformin, sitagliptin, and acarbose (Met+Sita+Acarb, n=66) and sitagliptin and acarbose (Sita+Acarb, exploratory assessment, n=34) therapy in five institutions in Korea. After 16 weeks of acarbose add-on or metformin-switch therapy, a triple combination therapy was maintained from week 16 to 24.

Results

The add-on of acarbose (Met+Sita+Acarb group) demonstrated a 0.44%±0.08% (P<0.001 vs. baseline) decrease in glycosylated hemoglobin (HbA1c) at week 16, while changes in HbA1c were insignificant in the Met+Sita group (−0.09%±0.10%, P=0.113). After 8 weeks of triple combination therapy, HbA1c levels were comparable between Met+Sita and Met+Sita+Acarb group (7.66%±0.13% vs. 7.47%±0.12%, P=0.321). Acarbose add-on therapy demonstrated suppressed glucagon secretion (area under the curve of glucagon, 4,726.17±415.80 ng·min/L vs. 3,314.38±191.63 ng·min/L, P=0.004) in the absence of excess insulin secretion during the meal tolerance tests at week 16 versus baseline. The incidence of adverse or serious adverse events was similar between two groups.

Conclusion

In conclusion, a 16-week acarbose add-on therapy to metformin and sitagliptin, effectively lowered HbA1c without significant adverse events. Acarbose might be a good choice as a third-line therapy in addition to metformin and sitagliptin in Korean subjects with T2DM who have predominant postprandial hyperglycemia and a high carbohydrate intake.

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Review

Complications
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis: Yong-ho Lee, Yongin Cho, Byung-Wan Lee, Cheol-Young Park, Dae Ho Lee, Bong-Soo Cha, Eun-Jung Rhee; Diabetes Metab J. 2019;43(1):31-45. Published online December 17, 2018; DOI: https://doi.org/10.4093/dmj.2019.0011; Correction in: Diabetes Metab J 2019;43(5):731

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Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.

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Original Article

Complications
Glycated Albumin Is a More Useful Glycation Index than HbA1c for Reflecting Renal Tubulopathy in Subjects with Early Diabetic Kidney Disease: Ji Hye Huh, Minyoung Lee, So Young Park, Jae Hyeon Kim, Byung-Wan Lee; Diabetes Metab J. 2018;42(3):215-223. Published online May 2, 2018; DOI: https://doi.org/10.4093/dmj.2017.0091

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Background

The aim of this study was to investigate which glycemic parameters better reflect urinary N-acetyl-β-D-glucosaminidase (uNAG) abnormality, a marker for renal tubulopathy, in subjects with type 2 diabetes mellitus (T2DM) subjects with normoalbuminuria and a normal estimated glomerular filtration rate (eGFR).

Methods

We classified 1,061 participants with T2DM into two groups according to uNAG level—normal vs. high (>5.8 U/g creatinine)—and measured their biochemical parameters.

Results

Subjects with high uNAG level had significantly higher levels of fasting and stimulated glucose, glycated albumin (GA), and glycosylated hemoglobin (HbA1c) and lower levels of homeostasis model assessment of β-cell compared with subjects with normal uNAG level. Multiple linear regression analyses showed that uNAG was significantly associated with GA (standardized β coefficient [β]=0.213, P=0.016), but not with HbA1c (β=−0.137, P=0.096) or stimulated glucose (β=0.095, P=0.140) after adjusting confounding factors. In receiver operating characteristic analysis, the value of the area under the curve (AUC) for renal tubular injury of GA was significantly higher (AUC=0.634; 95% confidence interval [CI], 0.646 to 0.899) than those for HbA1c (AUC=0.598; 95% CI, 0.553 to 0.640), stimulated glucose (AUC=0.594; 95% CI, 0.552 to 0.636), or fasting glucose (AUC=0.558; 95% CI, 0.515 to 0.600). The optimal GA cutoff point for renal tubular damage was 17.55% (sensitivity 59%, specificity 62%).

Conclusion

GA is a more useful glycation index than HbA1c for reflecting renal tubulopathy in subjects with T2DM with normoalbuminuria and normal eGFR.

Citations

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Reviews

Clinical Diabetes & Therapeutics
Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association: Hyun Jin Kim, Seok O Park, Seung-Hyun Ko, Sang Youl Rhee, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Byung-Wan Lee, Jin Hwa Kim, Kyung Mook Choi; Diabetes Metab J. 2017;41(6):423-429. Published online December 19, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.6.423

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The glucagon-like peptide-1 receptor agonists (GLP-1RAs) were recommended as a monotherapy or combination therapy with oral hypoglycemic agents or basal insulin in the position statement of the Korean Diabetes Association 2017 for pharmacological therapy. Many randomized clinical trials and systematic reviews report that GLP-1RAs have considerable glucose-lowering effect and lead to weight reduction and low risk of hypoglycemia when used as a monotherapy or combination therapy. The cardiovascular safety of GLP-1RAs has been assessed in several randomized clinical trials and systematic reviews. The results of cardiovascular outcome trials of long-acting GLP-1RAs (liraglutide, semaglutide) demonstrated cardiovascular benefits in subjects with type 2 diabetes mellitus and a high risk of cardiovascular disease. The GLP-1RA may be a choice of therapy when weight control and avoidance of hypoglycemia are important, and patients with high risk of cardiovascular disease might also favor choosing GLP-1RA.

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Clinical Diabetes & Therapeutics
Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017: Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi; Diabetes Metab J. 2017;41(5):367-373. Published online October 24, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.5.367

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The Korean Diabetes Association (KDA) has regularly updated its Clinical Practice Guidelines. In 2017, the KDA published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). Growing evidence from new multinational clinical trials using novel and traditional insulin analogues has also been accumulated. Following global trends, many results of clinical trials, especially concerning the clinical efficacy and safety of insulin therapy, have been published about Korean patients with T2DM. After a systematic search of recent evidence, the KDA updated and modified its clinical practice recommendations regarding the initiation, choice, and intensification of insulin and created an insulin treatment algorithm for the first time to guide physicians caring for adult Korean patients with T2DM.

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Clinical Diabetes & Therapeutics
Combination Therapy of Oral Hypoglycemic Agents in Patients with Type 2 Diabetes Mellitus: Min Kyong Moon, Kyu-Yeon Hur, Seung-Hyun Ko, Seok-O Park, Byung-Wan Lee, Jin Hwa Kim, Sang Youl Rhee, Hyun Jin Kim, Kyung Mook Choi, Nan-Hee Kim; Diabetes Metab J. 2017;41(5):357-366. Published online October 24, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.5.357

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The Korean Diabetes Association (KDA) recently updated the Clinical Practice Guidelines on antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus (T2DM). In combination therapy of oral hypoglycemic agents (OHAs), general recommendations were not changed from those of the 2015 KDA guidelines. The Committee on Clinical Practice Guidelines of the KDA has extensively reviewed and discussed the results of meta-analyses and systematic reviews of effectiveness and safety of OHAs and many clinical trials on Korean patients with T2DM for the update of guidelines. All OHAs were effective when added to metformin or metformin and sulfonylurea, although the effects of each agent on body weight and hypoglycemia were different. Therefore, selection of a second agent as a metformin add-on therapy or third agent as a metformin and sulfonylurea add-on therapy should be based on the patient's clinical characteristics and the efficacy, side effects, mechanism of action, risk of hypoglycemia, effect on body weight, patient preference, and combined comorbidity. In this review, we address the results of meta-analyses and systematic reviews, comparing the effectiveness and safety among OHAs. It will help to choose the appropriate drug for an individual patient with T2DM.

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Clinical Diabetes & Therapeutics
Monotherapy in Patients with Type 2 Diabetes Mellitus: Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim; Diabetes Metab J. 2017;41(5):349-356. Published online October 19, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.5.349

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Abstract PDF PubReader ePub

In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.

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Clinical Diabetes & Therapeutics
Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association: Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim; Diabetes Metab J. 2017;41(5):337-348. Published online October 17, 2017; DOI: https://doi.org/10.4093/dmj.2017.41.5.337

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In 2017, the Korean Diabetes Association (KDA) published a position statement on the use of antihyperglycemic agents for patients with type 2 diabetes mellitus (T2DM). The KDA regularly updates its Clinical Practice Guidelines, but since the last update in 2015, many results from clinical trials have been introduced, and domestic data from studies performed in Korean patients with T2DM have been published. Recently, evidence from large clinical studies assessing cardiovascular outcomes following the use of sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in patients with T2DM were incorporated into the recommendations. Additionally, new data from clinical trials using dipeptidyl peptidase 4 inhibitors and thiazolidinediones in Korean patients with T2DM were added. Following a systematic review and assessment of recent evidence, the KDA updated and modified its clinical practice recommendations regarding the use of antihyperglycemic agents and revised the treatment algorithm for Korean adult patients with T2DM.

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New anti-diabetic agents
Doo-Man Kim
Journal of the Korean Medical Association.2017; 60(12): 992. CrossRef
Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association
Hyun Jin Kim, Seok O Park, Seung-Hyun Ko, Sang Youl Rhee, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Byung-Wan Lee, Jin Hwa Kim, Kyung Mook Choi
Diabetes & Metabolism Journal.2017; 41(6): 423. CrossRef
Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017
Byung-Wan Lee, Jin Hwa Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Sang Youl Rhee, Hyun Jin Kim, Min Kyong Moon, Seok-O Park, Kyung Mook Choi
Diabetes & Metabolism Journal.2017; 41(5): 367. CrossRef

Response

Response: Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database (Diabetes Metab J 2015;39:247-52): Sunghwan Suh, Gi Hyeon Seo, Chang Hee Jung, Mee-Kyoung Kim, Sang-Man Jin, You-Cheol Hwang, Byung-Wan Lee, Jae Hyeon Kim; Diabetes Metab J. 2015;39(4):350-351. Published online August 17, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.4.350

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Original Articles

Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database: Sunghwan Suh, Gi Hyeon Seo, Chang Hee Jung, Mee-Kyoung Kim, Sang-Man Jin, You-Cheol Hwang, Byung-Wan Lee, Jae Hyeon Kim; Diabetes Metab J. 2015;39(3):247-252. Published online April 22, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.3.247

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Background

We assessed the association of dipeptidyl peptidase 4 inhibitors (DPP4i) with hospitalization for heart failure (HF) using the Korean Health Insurance claims database.

Methods

We collected data on newly prescribed sitagliptin, vildagliptin, and pioglitazone between January 1, 2009 and December 31, 2012 (mean follow-up of 336.8 days) to 935,519 patients with diabetes (518,614 males and 416,905 females) aged 40 to 79 years (mean age of 59.4 years).

Results

During the study, 998 patients were hospitalized for primary HF (115.7 per 100,000 patient-years). The incidence rate of hospitalization for HF was 117.7 per 100,000 per patient-years among patients on pioglitazone, 105.7 for sitagliptin, and 135.8 for vildagliptin. The hospitalization rate for HF was greatest in the first 30 days after starting the medication, which corresponded to a significantly higher incidence at days 0 to 30 compared with days 31 to 360 for all three drugs. The hazard ratios were 1.85 (pioglitazone), 2.00 (sitagliptin), and 1.79 (vildagliptin). The incidence of hospitalization for HF did not differ between the drugs for any time period.

Conclusion

This study showed an increase in hospitalization for HF in the initial 30 days of the DPP4i and pioglitazone compared with the subsequent follow-up period. However, the differences between the drugs were not significant.

Citations

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Pasqual Llongueras-Espí, Elena García-Romero, Josep Comín-Colet, José González-Costello
Biomolecules.2025; 15(9): 1342. CrossRef
Cardioprotective effects of dipeptidyl peptidase-4 inhibitors versus sulfonylureas in addition to metformin: A nationwide cohort study of patients with type 2 diabetes
Jui Wang, Hon-Yen Wu, Kuo-Liong Chien
Diabetes & Metabolism.2022; 48(3): 101299. CrossRef
Changing Fields-Diabetes Medications Invading the Cardiovascular Space
Lauren D. Breite, Mackenzie Steck, Brandon Tate Cutshall, Samarth P. Shah, Brandon E. Cave
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Srikanth Yandrapalli, Aaqib Malik, Adam Horblitt, Gayatri Pemmasani, Wilbert S. Aronow, William H. Frishman
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Effects of antidiabetic drugs on left ventricular function/dysfunction: a systematic review and network meta-analysis
Da-Peng Zhang, Li Xu, Le-Feng Wang, Hong-Jiang Wang, Feng Jiang
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Dipeptidyl peptidase-4 inhibitor compared with sulfonylurea in combination with metformin: cardiovascular and renal outcomes in a propensity-matched cohort study
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Cardiovascular Diabetology.2019;[Epub] CrossRef
Comparative Cardiovascular Risks of Dipeptidyl Peptidase-4 Inhibitors: Analyses of Real-world Data in Korea
Kyoung Hwa Ha, Bongseong Kim, Hae Sol Shin, Jinhee Lee, Hansol Choi, Hyeon Chang Kim, Dae Jung Kim
Korean Circulation Journal.2018; 48(5): 395. CrossRef
Worsening Heart Failure During the Use of DPP-4 Inhibitors
Milton Packer
JACC: Heart Failure.2018; 6(6): 445. CrossRef
Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
Tae Hee Ko, Jubert C. Marquez, Hyoung Kyu Kim, Seung Hun Jeong, SungRyul Lee, Jae Boum Youm, In Sung Song, Dae Yun Seo, Hye Jin Kim, Du Nam Won, Kyoung Im Cho, Mun Gi Choi, Byoung Doo Rhee, Kyung Soo Ko, Nari Kim, Jong Chul Won, Jin Han
Pflügers Archiv - European Journal of Physiology.2018; 470(2): 263. CrossRef
Do DPP-4 Inhibitors Cause Heart Failure Events by Promoting Adrenergically Mediated Cardiotoxicity?
Milton Packer
Circulation Research.2018; 122(7): 928. CrossRef
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Hyouk-Jun Chin, Jin Hyun Nam, Eui-Kyung Lee, Ju-Young Shin
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Nattayaporn Apaijai, Tharnwimol Inthachai, Suree Lekawanvijit, Siriporn C Chattipakorn, Nipon Chattipakorn
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Christos V. Rizos, Anastazia Kei, Moses S. Elisaf
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Simón Quetzalcoatl Rodríguez-Lara, Ernesto German Cardona-Muñoz, Ernesto Javier Ramírez-Lizardo, Sylvia Elena Totsuka-Sutto, Araceli Castillo-Romero, Teresa Arcelia García-Cobián, Leonel García-Benavides, Kota V. Ramana
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Letter: Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database (Diabetes Metab J2015;39:247-52)
Dae Ho Lee
Diabetes & Metabolism Journal.2015; 39(4): 348. CrossRef
Response: Increased Risk of Hospitalization for Heart Failure with Newly Prescribed Dipeptidyl Peptidase-4 Inhibitors and Pioglitazone Using the Korean Health Insurance Claims Database (Diabetes Metab J2015;39:247-52)
Sunghwan Suh, Gi Hyeon Seo, Chang Hee Jung, Mee-Kyoung Kim, Sang-Man Jin, You-Cheol Hwang, Byung-Wan Lee, Jae Hyeon Kim
Diabetes & Metabolism Journal.2015; 39(4): 350. CrossRef
Cardiovascular, renal and gastrointestinal effects of incretin-based therapies: an acute and 12-week randomised, double-blind, placebo-controlled, mechanistic intervention trial in type 2 diabetes
Mark M Smits, Lennart Tonneijck, Marcel H A Muskiet, Trynke Hoekstra, Mark H H Kramer, Indra C Pieters, Djuna L Cahen, Michaela Diamant, Daniël H van Raalte
BMJ Open.2015; 5(11): e009579. CrossRef
Dipeptidyl Peptidase-4 Inhibitor Alarms: Is Heart Failure Caused by a Class Effect?
Yong-ho Lee
Diabetes & Metabolism Journal.2015; 39(3): 204. CrossRef

1,5-Anhydroglucitol as a Useful Marker for Assessing Short-Term Glycemic Excursions in Type 1 Diabetes: Hannah Seok, Ji Hye Huh, Hyun Min Kim, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong Soo Cha; Diabetes Metab J. 2015;39(2):164-170. Published online March 9, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.2.164

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Background

Type 1 diabetes is associated with more severe glycemic variability and more frequent hypoglycemia than type 2 diabetes. Glycemic variability is associated with poor glycemic control and diabetic complications. In this study, we demonstrate the clinical usefulness of serum 1,5-anhydroglucitol (1,5-AG) for assessing changes in glycemic excursion in type 1 diabetes.

Methods

Seventeen patients with type 1 diabetes were enrolled in this study. A continuous glucose monitoring system (CGMS) was applied twice at a 2-week interval to evaluate changes in glycemic variability. The changes in serum glycemic assays, including 1,5-AG, glycated albumin and hemoglobin A1c (HbA1c), were also evaluated.

Results

Most subjects showed severe glycemic excursions, including hypoglycemia and hyperglycemia. The change in 1,5-AG level was significantly correlated with changes in the glycemic excursion indices of the standard deviation (SD), mean amplitude of glucose excursion (MAGE), lability index, mean postmeal maximum glucose, and area under the curve for glucose above 180 mg/dL (r=-0.576, -0.613, -0.600, -0.630, and -0.500, respectively; all P<0.05). Changes in glycated albumin were correlated with changes in SD and MAGE (r=0.495 and 0.517, respectively; all P<0.05). However, changes in HbA1c were not correlated with any changes in the CGMS variables.

Conclusion

1,5-AG may be a useful marker for the assessment of short-term changes in glycemic variability. Furthermore, 1,5-AG may have clinical implications for the evaluation and treatment of glycemic excursions in type 1 diabetes.

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The Glycated Albumin to Glycated Hemoglobin Ratio Might Not Be Associated with Carotid Atherosclerosis in Patients with Type 1 Diabetes: Wonjin Kim, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee; Diabetes Metab J. 2014;38(6):456-463. Published online December 15, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.6.456

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Background

The ratio of glycated albumin to glycated hemoglobin (GA/A1c) is known to be elevated in subjects with type 2 diabetes mellitus (T2DM) who had decreased insulin secretion. Additionally, the carotid intima media thickness (IMT) is greater in T2DM patients with higher GA/A1c ratios. We investigated whether increased GA/A1c ratio and IMT are also associated in type 1 diabetes mellitus (T1DM), which is characterized by lack of insulin secretory capacity.

Methods

In this cross-sectional study, we recruited 81 T1DM patients (33 men, 48 women; mean age 44.1±13.0 years) who underwent carotid IMT, GA, and HbA1c measurements.

Results

The mean GA/A1c ratio was 2.90. Based on these results, we classified the subjects into two groups: group I (GA/A1c ratio <2.90, n=36) and group II (GA/A1c ratio ≥2.90, n=45). Compared with group I, the body mass indexes (BMIs), waist circumferences, and IMTs were lower in group II. GA/A1c ratio was negatively correlated with BMI, urine albumin to creatinine ratio (P<0.001 for both), and both the mean and maximal IMT (P=0.001, both). However, after adjusting the confounding factors, we observed that IMT was no longer associated with GA/A1c ratio.

Conclusion

In contrast to T2DM, IMT was not significantly related to GA/A1c ratio in the subjects with T1DM. This suggests that the correlations between GA/A1c ratio and the parameters known to be associated with atherosclerosis in T2DM could be manifested differently in T1DM. Further studies are needed to investigate these relationships in T1DM.

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High glycated albumin is associated with early neurological deterioration in patients with acute ischemic stroke
Ki-Woong Nam, Jung Hoon Han, Chi Kyung Kim, Hyung-Min Kwon, Yong-Seok Lee, Kyungmi Oh, Keon-Joo Lee, Byeongsu Park
BMC Neurology.2024;[Epub] CrossRef
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Jeongseon Yoo, Youngah Choi, Shin Ae Park, Ji Yeon Seo, Chul Woo Ahn, Jaehyun Han
Journal of Clinical Medicine.2022; 11(9): 2327. CrossRef
Variability in glycated albumin levels predicts the progression of diabetic nephropathy
Su Bin Park, Sang Soo Kim, In Joo Kim, Yoon Jeong Nam, Kang Hee Ahn, Jong Ho Kim, Yun Kyung Jeon, Bo Hyun Kim, Sang Heon Song, Ihm Soo Kwak, Eun Kyung Lee, Yong Ki Kim
Journal of Diabetes and its Complications.2017; 31(6): 1041. CrossRef
Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease
Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim, Salvatore Petta
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Determinants of Preclinical Atherosclerosis Are Different in Type 1 and Type 2 Diabetic Women
P. PIŤHOVÁ, K. ŠTECHOVÁ, J. PIŤHA, V. LÁNSKÁ, M. KVAPIL
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Gyuri Kim, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Byung-Wan Lee
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Visceral adiposity is associated with altered myocardial glucose uptake measured by 18FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes
Gyuri Kim, Kwanhyeong Jo, Kwang Joon Kim, Yong-ho Lee, Eugene Han, Hye-jin Yoon, Hye Jin Wang, Eun Seok Kang, Mijin Yun
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Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes
Hye-jin Yoon, Yong-ho Lee, So Ra Kim, Tyler Hyungtaek Rim, Eun Young Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Lee, Byung-Wan Lee
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Background and Data Configuration Process of a Nationwide Population-Based Study Using the Korean National Health Insurance System: Sun Ok Song, Chang Hee Jung, Young Duk Song, Cheol-Young Park, Hyuk-Sang Kwon, Bong Soo Cha, Joong-Yeol Park, Ki-Up Lee, Kyung Soo Ko, Byung-Wan Lee; Diabetes Metab J. 2014;38(5):395-403. Published online October 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.5.395

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Background

The National Health Insurance Service (NHIS) recently signed an agreement to provide limited open access to the databases within the Korean Diabetes Association for the benefit of Korean subjects with diabetes. Here, we present the history, structure, contents, and way to use data procurement in the Korean National Health Insurance (NHI) system for the benefit of Korean researchers.

Methods

The NHIS in Korea is a single-payer program and is mandatory for all residents in Korea. The three main healthcare programs of the NHI, Medical Aid, and long-term care insurance (LTCI) provide 100% coverage for the Korean population. The NHIS in Korea has adopted a fee-for-service system to pay health providers. Researchers can obtain health information from the four databases of the insured that contain data on health insurance claims, health check-ups and LTCI.

Results

Metabolic disease as chronic disease is increasing with aging society. NHIS data is based on mandatory, serial population data, so, this might show the time course of disease and predict some disease progress, and also be used in primary and secondary prevention of disease after data mining.

Conclusion

The NHIS database represents the entire Korean population and can be used as a population-based database. The integrated information technology of the NHIS database makes it a world-leading population-based epidemiology and disease research platform.

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Abdominal aortic aneurysm and gout risk: A nationwide population-based observational cohort study
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Journal of Cardiovascular Pharmacology.2026; 87(3): 201. CrossRef
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Journal of Korean Medical Science.2026;[Epub] CrossRef
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Journal of Korean Medical Science.2026;[Epub] CrossRef
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Annals of Hepatology.2026; 31(1): 102175. CrossRef
Erythropoiesis-Stimulating Agents and Development of Cancer Among Patients Receiving Dialysis
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JAMA Network Open.2026; 9(2): e260140. CrossRef
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Journal of Nervous & Mental Disease.2026; 214(1): 1. CrossRef
Big data–driven observational evidence in Korea: challenges in interpreting non-randomized studies
Jong Han Choi
Journal of Evidence-Based Practice.2026; 2(1): 16. CrossRef
Maculopathy in Paclitaxel Users
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Ophthalmology Retina.2026;[Epub] CrossRef
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Journal of Diabetes.2026;[Epub] CrossRef
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Cancer Epidemiology, Biomarkers & Prevention.2026; 35(5): 743. CrossRef
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European Journal of Public Health.2026;[Epub] CrossRef
Risk of Cardiovascular Disease According to Standard Industrial Sectors: A Nationwide Longitudinal Study
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Journal of Korean Medical Science.2026;[Epub] CrossRef
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Journal of Neuroimmunology.2026; 418: 578961. CrossRef
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BMC Geriatrics.2026;[Epub] CrossRef
Effectiveness of bivalent COVID-19 vaccines against SARS-CoV-2 reinfection in patients with cancer: Evidence from a nationwide target trial emulation
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Journal of Infection.2026; 92(6): 106753. CrossRef
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Liver International.2026;[Epub] CrossRef
Topical corticosteroid use and risk of type 2 diabetes mellitus: a nationwide cohort study
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British Journal of Dermatology.2026;[Epub] CrossRef
Illustrating Poststratification Methods in Medical Claims Data: A Korean Example
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Epidemiology.2026; 37(4): 494. CrossRef
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Alzheimer's Research & Therapy.2026;[Epub] CrossRef
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Anesthesiology.2026; 145(1): 135. CrossRef
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Diabetes Research and Clinical Practice.2026; 238: 113351. CrossRef
Acupuncture‐Related Therapies as a Potential Adjuvant Option for Parkinson’s Disease: Effects on Symptom Management, Medication Use, and Mortality
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Parkinson's Disease.2026;[Epub] CrossRef
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Seon Young Song, Jiyeong Kim, Yu‐Mi Kim, Joo Yeon Ko
Journal of the European Academy of Dermatology and Venereology.2026;[Epub] CrossRef
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Neuroepidemiology.2026; : 1. CrossRef
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BMC Medicine.2026;[Epub] CrossRef
Iodinated Contrast Media Hypersensitivity in 115,966 Patients
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Investigative Radiology.2026;[Epub] CrossRef
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Value in Health.2026;[Epub] CrossRef
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Diabetes, Obesity and Metabolism.2026;[Epub] CrossRef
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JAMA Network Open.2026; 9(6): e2620030. CrossRef
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Rheumatology.2025; 64(1): 173. CrossRef
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Digestive and Liver Disease.2025; 57(1): 176. CrossRef
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American Journal of Gastroenterology.2025; 120(2): 410. CrossRef
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Internal and Emergency Medicine.2025; 20(1): 105. CrossRef
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Ophthalmology Retina.2025; 9(4): 386. CrossRef
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Rheumatology.2025; 64(5): 2601. CrossRef
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JHEP Reports.2025; 7(4): 101313. CrossRef
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Journal of the American Heart Association.2025;[Epub] CrossRef
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American Journal of Gastroenterology.2025; 120(10): 2361. CrossRef
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Diabetes Care.2025; 48(3): 422. CrossRef
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Obesity Surgery.2025; 35(2): 463. CrossRef
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European Journal of Cardio-Thoracic Surgery.2025;[Epub] CrossRef
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Journal of Preventive Medicine and Public Health.2025; 58(1): 60. CrossRef
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European Respiratory Journal.2025; 65(2): 2401484. CrossRef
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PLOS ONE.2025; 20(2): e0316943. CrossRef
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World Journal of Gastrointestinal Oncology.2025;[Epub] CrossRef
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BMJ Mental Health.2025; 28(1): e301306. CrossRef
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Frontiers in Oncology.2025;[Epub] CrossRef
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Yonsei Medical Journal.2025; 66(7): 429. CrossRef
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BMJ Open.2025; 15(3): e087884. CrossRef
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Scientific Reports.2025;[Epub] CrossRef
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BMC Public Health.2025;[Epub] CrossRef
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Journal of Cardiology.2025; 86(4): 380. CrossRef
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Occupational Medicine.2025; 75(2): 113. CrossRef
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PLOS One.2025; 20(4): e0322892. CrossRef
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American Journal of Kidney Diseases.2025; 86(2): 166. CrossRef
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International Journal of Cardiology.2025; 437: 133425. CrossRef
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Clinical and Experimental Otorhinolaryngology.2025; 18(2): 123. CrossRef
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BMJ Public Health.2025; 3(1): e002020. CrossRef
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Journal of Cardiovascular Development and Disease.2025; 12(7): 244. CrossRef
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Cardiovascular Diabetology.2025;[Epub] CrossRef
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Diabetes Research and Clinical Practice.2025; 227: 112405. CrossRef
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Epidemiology and Health.2025; 47: e2025035. CrossRef
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Journal of Dental Hygiene Science.2025; 25(3): 214. CrossRef
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ESC Heart Failure.2025; 12(6): 4242. CrossRef
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Mayo Clinic Proceedings.2025; 100(10): 1758. CrossRef
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Pharmacoepidemiology and Drug Safety.2025;[Epub] CrossRef
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Frontiers in Oncology.2025;[Epub] CrossRef
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Arthritis Care & Research.2025; 77(12): 1466. CrossRef
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Diabetes & Metabolism Journal.2025; 49(5): 1106. CrossRef
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European Heart Journal - Quality of Care and Clinical Outcomes.2025; 11(8): 1377. CrossRef
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European Journal of Cancer.2025; 231: 116094. CrossRef
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Journal of Obesity & Metabolic Syndrome.2025; 34(4): 405. CrossRef
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Child Health Nursing Research.2025; 31(4): 221. CrossRef
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Diabetes & Metabolism Journal.2025; 49(6): 1308. CrossRef
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World Journal of Gastroenterology.2025;[Epub] CrossRef
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European Heart Journal.2025;[Epub] CrossRef
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BMC Cancer.2025;[Epub] CrossRef
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Frontiers in Neurology.2025;[Epub] CrossRef
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Cardiovascular Therapeutics.2025;[Epub] CrossRef
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Medicine & Science in Sports & Exercise.2025; 57(12): 2640. CrossRef
Central Adiposity, Obesity, Metabolic Syndrome, and the Risk of Thyroid Cancer in Adults Aged ≥75 Years: A Nationwide Korean Cohort Study
Kyung Do Han, Kwan Hoon Jo, Yunjung Cho, Hyuk-Sang Kwon, Je-Ho Han, Sung-Dae Moon, Eun Sook Kim
Cancers.2025; 18(1): 49. CrossRef
Various Antihypertensive Drug Compliance Models and Cardiovascular Prognosis of People With Incidentally Detected High Blood Pressure During Health Check‐Up in Korea
Jong-Kwan Park, Sungyoun Chun, Joongmin Kim, Hancheol Lee, Ji-Yong Jang, Kyeong-Hyeon Chun, Hyeongsoo Kim, Seung-Jin Oh, Geunhee Park, Se-Jung Yoon, Peng Geng
International Journal of Hypertension.2025;[Epub] CrossRef
Disease Burden and Treatment Pattern of Advanced or Recurrent Endometrial Cancer in Korea: A Nationwide Database (DIRECTION) Study
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Surgical ablation for atrial fibrillation during aortic and mitral valve surgery: A nationwide population-based cohort study
Ho Jin Kim, Ye-Jee Kim, Minju Kim, Jae Suk Yoo, Dae-Hee Kim, Duk-Woo Park, Sung-Ho Jung, Suk Jung Choo, Joon Bum Kim
The Journal of Thoracic and Cardiovascular Surgery.2024; 167(3): 981. CrossRef
Early and long-term outcomes of bioprosthetic versus mechanical tricuspid valve replacement: A nationwide population-based study
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The Journal of Thoracic and Cardiovascular Surgery.2024; 167(6): 2117. CrossRef
A Nationwide Population‐Based Study for the Recurrence and Comorbidities in Sudden Sensorineural Hearing Loss
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The Laryngoscope.2024; 134(3): 1417. CrossRef
Volatile Anesthetic Use Versus Total Intravenous Anesthesia for Patients Undergoing Heart Valve Surgery: A Nationwide Population-Based Study
Jae-Woo Ju, Ho-Jin Lee, Karam Nam, Seungwook Kim, Hyunsook Hong, Seung Ho Yoo, Seohee Lee, Youn Joung Cho, Yunseok Jeon
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Duration of dual-antiplatelet therapy after stent-assisted coil for unruptured intracranial aneurysm: A nationwide cohort study
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International Journal of Stroke.2024; 19(3): 359. CrossRef
Bovine pericardial versus porcine bioprosthetic aortic valves: A nationwide population-based cohort study in Korea
Hong Rae Kim, Ho Jin Kim, Seonok Kim, Yejee Kim, Jung-Min Ahn, Joon Bum Kim, Dae-Hee Kim
The Journal of Thoracic and Cardiovascular Surgery.2024; 168(5): 1438. CrossRef
Risk of dementia in survivors of active tuberculosis in Korea: A nationwide cohort study
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Journal of Infection and Public Health.2024; 17(2): 286. CrossRef
Incidence and Clinical Characteristics of Slipped Capital Femoral Epiphysis in Patients with Endocrinopathy
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Journal of Bone and Joint Surgery.2024; 106(5): 381. CrossRef
A nationwide study of regional preference and graft survival of kidney transplantation in South Korea: patterns of centralization in the capital area
Jeong-Ik Park, Youngjin Jang, Hojong Park, Sungchoul Pyun, Hong Rae Cho, Sang Jun Park
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Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study
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Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study
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Diabetes Research and Clinical Practice.2024; 208: 111098. CrossRef
Trends in Healthy Life Expectancy (HALE) and Disparities by Income and Region in Korea (2008–2020): Analysis of a Nationwide Claims Database
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Journal of Korean Medical Science.2024;[Epub] CrossRef
Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus
Joo Hee Jeong, Yun Gi Kim, Kyung-Do Han, Seung-Young Roh, Hyoung Seok Lee, Yun Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
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Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study
Minyoul Baik, Jimin Jeon, Jinkwon Kim, Joonsang Yoo
Stroke and Vascular Neurology.2024; 9(5): 560. CrossRef
Association of lifestyle modification with the development of cardiovascular disease in gastric cancer patients who underwent gastrectomy: A nationwide population‐based study
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Cancer Medicine.2024;[Epub] CrossRef
Trend in the Incidence of Severe Partial Edentulism among Adults Using the Korean National Health Insurance Service Claim Data, 2014–2018
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Yonsei Medical Journal.2024; 65(4): 234. CrossRef
Real-World Impact of Modern Reperfusion Therapy for Acute Ischemic Stroke : A Nationwide Population-Based Data Study in Korea
Yung Ki Park, Byul-Hee Yoon, Yu Deok Won, Jae Hoon Kim, Hee In Kang
Journal of Korean Neurosurgical Society.2024; 67(2): 186. CrossRef
Risk of Secondary Malignancies After Multiple Myeloma: A Nationwide Case-Control Cohort Study
Heejoo Ko, Seunghoon Han, Sung-Soo Park, Suein Choi, Ja Min Byun, Chang-Ki Min
Clinical Lymphoma Myeloma and Leukemia.2024; 24(10): e366. CrossRef
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Intensity of statin therapy and primary prevention of cardiovascular in Korean patients with dyslipidemia
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British Journal of Dermatology.2024; 190(6): 858. CrossRef
Risk of incident chronic kidney disease among patients with urolithiasis: a nationwide longitudinal cohort study
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Clinical benefits of surgical ablation during isolated aortic valve replacement: a nationwide study
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European Journal of Cardio-Thoracic Surgery.2024;[Epub] CrossRef
Risk of Cardiovascular Disease according to Baseline Low-Density Lipoprotein Cholesterol Level in Different Age Groups in Korean Diabetes Population: A Cohort Study
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The Association of Body Mass Index and Waist Circumference with Sepsis-Related Mortality in South Korea
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An Ensemble Feature Selection Approach-Based Machine Learning Classifiers for Prediction of COVID-19 Disease
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Korea4K: whole genome sequences of 4,157 Koreans with 107 phenotypes derived from extensive health check-ups
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Beyond Symptoms: Radiologic identification of asymptomatic Mycobacterium avium complex pulmonary infections
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Respiratory Medicine.2024; 226: 107627. CrossRef
Association between migraine and the risk of vascular dementia: A nationwide longitudinal study in South Korea
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Income variability and incident cardiovascular disease in diabetes: a population-based cohort study
Yong-Moon Mark Park, Jong-Ha Baek, Hong Seok Lee, Tali Elfassy, Clare C Brown, Mario Schootman, Marie-Rachelle Narcisse, Seung-Hyun Ko, Pearl A McElfish, Michael R Thomsen, Benjamin C Amick, Seong-Su Lee, Kyungdo Han
European Heart Journal.2024; 45(21): 1920. CrossRef
Inhibition of sodium-glucose cotransporter-2 and liver-related complications in individuals with diabetes: a Mendelian randomization and population-based cohort study
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Hepatology.2024; 80(3): 633. CrossRef
Risk Factors of Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study
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Proton Pump Inhibitor for Gastrointestinal Bleeding in Patients with Myocardial Infarction on Dual-Antiplatelet Therapy: A Nationwide Cohort Study
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Cancer Incidence Among Residents Near Coal-Fired Power Plants Based on the Korean National Health Insurance System Data
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Fenofibrate’s impact on cardiovascular risk in patients with diabetes: a nationwide propensity-score matched cohort study
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Chronic periodontal disease is related with newly developing hypertension: a nationwide cohort study
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Elevated Risk of Stroke in Young Adults After Traumatic Brain Injury: A Nationwide Study of 1 Million Individuals
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Journal of the American Heart Association.2024;[Epub] CrossRef
Improved Proteinuria May Attenuate the Risk of Atrial Fibrillation: A Nationwide Population-Based Cohort Study
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Estimated economic costs of dental implants among older South Korean adults, 2015–2018
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Risk of depression in amyotrophic lateral sclerosis: A nationwide cohort study in South Korea
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Journal of Psychiatric Research.2024; 178: 414. CrossRef
Association Between Influenza Vaccination and Acute Kidney Injury Among the Elderly: A Self‐Controlled Case Series
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Inequality in Mortality and Cardiovascular Risk Among Young, Low-Income, Self-Employed Workers: Nationwide Retrospective Cohort Study
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Changes in seasonality and sex ratio of scrub typhus: a case study of South Korea from 2003 to 2019 based on wavelet transform analysis
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SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes
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Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated with Increased Risk of Kidney Cancer: A Nationwide Study
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Non-Alcoholic Fatty Liver Disease and Its Association with Kidney and Cardiovascular Outcomes in Moderate to Advanced Chronic Kidney Disease
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American Journal of Nephrology.2024; : 1. CrossRef
High-Volume Hospital Had Lower Mortality of Severe Intracerebral Hemorrhage Patients
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Journal of Korean Neurosurgical Society.2024; 67(6): 622. CrossRef
Impact of Chronic Kidney Disease and Gout on End-Stage Renal Disease in Type 2 Diabetes: Population-Based Cohort Study
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Endocrinology and Metabolism.2024; 39(5): 748. CrossRef
Nationwide Trends in Helicobacter pylori Eradication Therapies in Korea: Impact of Guideline Updates on Treatment Practices
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Helicobacter.2024;[Epub] CrossRef
Increased risk of open angle glaucoma in patients with moyamoya disease from a nationwide population-based cohort in Korea
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Association Between Higher Body Mass Index and the Risk of Lumbar Spinal Stenosis in Korean Populations: A Nationwide Cohort Study
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Association of age at menopause and suicide risk in postmenopausal women: a nationwide cohort study
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Frontiers in Psychiatry.2024;[Epub] CrossRef
Incidence and prevalence of seropositive rheumatoid arthritis among Korean women of childbearing age: a nationwide population-based study
Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyun Sun Lim, Jisoo Lee
The Korean Journal of Internal Medicine.2023; 38(1): 125. CrossRef
Myth and Truth in Opioid Consumption with Intrathecal Morphine Pump Implantation in Chronic Pain: A Retrospective Cohort Study with Claims Database in South Korea
Yongjae Yoo, Joo Hyeon Oh, Haine Lee, Hyunsook Choi, Somin Joo, Andrew Hogyu Han, Jee Youn Moon
Pain Medicine.2023; 24(1): 79. CrossRef
Epidemiology of idiopathic sudden sensorineural hearing loss in the era of big data
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European Archives of Oto-Rhino-Laryngology.2023; 280(5): 2181. CrossRef
Allergic Diseases and Risk of Incident Dementia and Alzheimer's Disease
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Annals of Neurology.2023; 93(2): 384. CrossRef
Post-operative recurrence of liver cancer according to antiviral therapy for detectable hepatitis B viremia: A nationwide study
Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin-Ha Yoon, Beom Kyung Kim
European Journal of Internal Medicine.2023; 107: 66. CrossRef
Comparable Mortality Between Asian Patients with Chronic Hepatitis B Under Long-Term Antiviral Therapy vs Matched Control: A Population-Based Study
Byungyoon Yun, Juyeon Oh, Sang Hoon Ahn, Jin-Ha Yoon, Beom Kyung Kim
American Journal of Gastroenterology.2023; 118(6): 1001. CrossRef
Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years)
Jung Eun Yoo, Kyungdo Han, Jin‐Hyung Jung, Yang‐Im Hur, Yang Hyun Kim, Eun Sook Kim, Jang Won Son, Eun‐Jung Rhee, Won‐Young Lee, Ga Eun Nam
Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 369. CrossRef
Waist circumference and end‐stage renal disease based on glycaemic status: National Health Insurance Service data 2009–2018
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Journal of Cachexia, Sarcopenia and Muscle.2023; 14(1): 585. CrossRef
Comparison of Trends in the Incidence of Traumatic Spinal Cord Injury in Daily Life, Automobile Accidents, and Industrial Accidents: A National Multi-Insurance Study in Korea
Yoonjeong Choi, Young-Eun Kim, Ja-Ho Leigh, Ye Seol Lee, Han-Kyoul Kim, You Gyoung Yi, Jinyoung Lee, Min-Yong Lee, Gangpyo Lee, Hyung-Ik Shin, Moon Suk Bang
Journal of Korean Medical Science.2023;[Epub] CrossRef
A population-based study on the risk of prescription opioid abuse in patients with chronic opioid use and cost-effectiveness of prescription drug monitoring program using a patient simulation model in South Korea
Siin Kim, Hae Sun Suh
International Journal of Drug Policy.2023; 112: 103953. CrossRef
The effects of sociodemographic factors on help-seeking for depression: Based on the 2017–2020 Korean Community Health Survey
JinYoung Lee, Kyeong-Sook Choi, Ji-Ae Yun, Pedro Vieira da Silva Magalhaes
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Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea: A nationwide retrospective cohort
Hyejin Jung, Tiana Won, Ga-Yeon Kim, Jowon Jang, Sujung Yeo, Sabina Lim
Journal of Integrative Medicine.2023; 21(2): 176. CrossRef
A 12-year nationwide cohort study on the association between central retinal artery occlusion and cancer
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Graefe's Archive for Clinical and Experimental Ophthalmology.2023;[Epub] CrossRef
Long-Term Nonoperative Management is Associated With Lower Mean 9-Year Follow-Up Survival Compared to Total Knee Arthroplasty in Knee Osteoarthritis Patients—Survival Analysis of a Nationwide South Korean Cohort
Hyein Han, Du Hyun Ro, Sungho Won, Hyuk-Soo Han
The Journal of Arthroplasty.2023; 38(8): 1470. CrossRef
Positive faecal immunochemical test predicts the onset of inflammatory bowel disease: A nationwide, propensity score-matched study
Eunyoung Lee, Gil Ho Lee, Bumhee Park, Sung Soo Ahn, Choong-Kyun Noh
Frontiers in Immunology.2023;[Epub] CrossRef
Scheduling and Predictive Maintenance for Smart Toilet
Amar Lokman, R. Kanesaraj Ramasamy, Choo-Yee Ting
IEEE Access.2023; 11: 17983. CrossRef
Incidence of Retinal Artery Occlusion and Related Mortality in Korea, 2005 to 2018
Daniel Duck-Jin Hwang, Kyung-Eun Lee, Yuwon Kim, Myoung-Suk Kim, Tyler Hyungtaek Rim, Mina Kim, Hasung Kim, Dae-Sung Kyoung, Ji In Park
JAMA Network Open.2023; 6(3): e233068. CrossRef
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Dojoon Park, Yong-Moon Park, Seung-Hyun Ko, Kang-Se Hyun, Youn-Ho Choi, Dong-Uk Min, Kyungdo Han, Hae-Seok Koh
Scientific Reports.2023;[Epub] CrossRef
Prior Lifestyle and Survival Outcomes After Intensive Care Unit Admission
In-Ae Song, Tak Kyu Oh
Journal of Korean Medical Science.2023;[Epub] CrossRef
Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Are Associated With Reduced Risk of SARS-CoV-2 Infection Without Comorbidities Including Diabetes, Hypertension, and Dyslipidemia: A Propensity Score-Matched Nationwide Cohort Study
Bokyung Kim, Jin-Hyung Jung, Kyungdo Han, Seungkyung Kang, Eunwoo Lee, Hyunsoo Chung, Sang Gyun Kim, Soo-Jeong Cho
Journal of Korean Medical Science.2023;[Epub] CrossRef
Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study
Mi Hee Cho, Kyungdo Han, Seungwoo Lee, Su-Min Jeong, Jung Eun Yoo, SangYun Kim, Jinkook Lee, Sohyun Chun, Dong Wook Shin
Alzheimer's Research & Therapy.2023;[Epub] CrossRef
Increased risk of cardiovascular disease associated with diabetes among adult cancer survivors: a population-based matched cohort study
Sanghyun Oh, Jihwan Lee, Yoo S Hong, Kyuwoong Kim
European Journal of Preventive Cardiology.2023; 30(8): 670. CrossRef
Association between familial aggregation of chronic kidney disease and its incidence and progression
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Scientific Reports.2023;[Epub] CrossRef
Participation and Prognostic Impact of Cardiac Rehabilitation After Acute Coronary Syndrome: Big-Data Study of the Korean National Health Insurance Service
Hee-Eun Choi, Chul Kim, Da-Jung Lee, Jae-Eun Joo, Ho-Seob Kim
Journal of Korean Medical Science.2023;[Epub] CrossRef
Analysis of Anxiety or Depression and Long-term Mortality Among Survivors of Out-of-Hospital Cardiac Arrest
Juncheol Lee, Yongil Cho, Jaehoon Oh, Hyunggoo Kang, Tae Ho Lim, Byuk Sung Ko, Kyung Hun Yoo, Sang Hwan Lee
JAMA Network Open.2023; 6(4): e237809. CrossRef
Treatment Changes and Prognoses in Patients with Incident Drug-Induced Parkinsonism Using a Korean Nationwide Healthcare Claims Database
Siin Kim, Hae Sun Suh
Journal of Clinical Medicine.2023; 12(8): 2860. CrossRef
Trends in the Incidence and Etiology of Non-Traumatic Spinal Cord Injury in Korea: A Nationwide Population-Based Study From 2007 to 2020
Yoonjeong Choi, Ja-Ho Leigh, Jooeun Jeon, Goo Joo Lee, Hyung-Ik Shin, Moon Suk Bang
Journal of Korean Medical Science.2023;[Epub] CrossRef
The Association between Metabolic Syndrome and Epithelial Cell Abnormalities Detected on Pap Smear: A Nationwide Population-Based Study
Dayong Lee, Taek Sang Lee
Journal of Clinical Medicine.2023; 12(8): 2954. CrossRef
Long‐term adverse neurodevelopmental outcomes of discordant twins delivered at term: A nationwide population‐based study
Eun‐Saem Choi, Young Mi Jung, Kyu‐Dong Cho, Sungyeon Ha, Jeongwon Sohn, Su Jung Hong, Min‐Jeong Oh, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee, Geum Joon Cho
BJOG: An International Journal of Obstetrics & Gynaecology.2023; 130(11): 1370. CrossRef
Cancer and Mortality Risks of Graves’ Disease in South Korea Based on National Data from 2010 to 2019
Young Ju Choi, Kyungdo Han, Won Kyoung Cho, Min Ho Jung, Byung-Kyu Suh
Clinical Epidemiology.2023; Volume 15: 535. CrossRef
Association of Waist Circumference with the Risk of Inflammatory Bowel Disease: a Nationwide Cohort Study of 10 Million Individuals in Korea
Yeonjin Je, Kyungdo Han, Jaeyoung Chun, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jong Pil Im, Joo Sung Kim
Journal of Crohn's and Colitis.2023; 17(5): 681. CrossRef
Lifestyle factors and long-term survival in patients with chronic non-cancer pain: a nationwide cohort study in South Korea
Tak Kyu Oh, In-Ae Song
Journal of Anesthesia.2023; 37(4): 522. CrossRef
Long term renal outcome after hypertensive disease during pregnancy: a nationwide population-based study
Kwang Hyun Lee, Ji Hye Bae, Jeesun Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Geum Joon Cho, Seung Mi Lee
Obstetrics & Gynecology Science.2023; 66(3): 190. CrossRef
Lower risk of depression after smoking cessation and alcohol abstinence in patients with gastric cancer who underwent gastrectomy: A population‐based, nationwide cohort study
Bokyung Kim, Kyungdo Han, Hyunsoo Chung, Sang Gyun Kim, Soo‐Jeong Cho
Cancer.2023; 129(18): 2893. CrossRef
Acute Pancreatitis and the Risk of Dementia in Diabetes: A Nationwide Cohort Study Using Korean Healthcare Claims Database
Woo Hyun Paik, Dong Kee Jang, Soyoung Cho, Jin Ho Choi, Min Kyu Kim, In Rae Cho, Ji Kon Ryu, Yong-Tae Kim, Kyung-Do Han, Sang Hyub Lee
Journal of Alzheimer’s Disease.2023; 94(1): 205. CrossRef
Application of big data in ophthalmology
Zhi Da Soh, Ching-Yu Cheng
Taiwan Journal of Ophthalmology.2023; 13(2): 123. CrossRef
Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study
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Cardiovascular Diabetology.2023;[Epub] CrossRef
Evaluating Reference Ages for Selecting Prosthesis Types for Heart Valve Replacement in Korea
Sung Jun Park, You Jung Ok, Ho Jin Kim, Ye-Jee Kim, Seonok Kim, Jung-Min Ahn, Dae-Hee Kim, Jae-Sung Choi, Joon Bum Kim
JAMA Network Open.2023; 6(5): e2314671. CrossRef
Higher Non-High-Density Lipoprotein Cholesterol Was Higher Associated With Cardiovascular Disease Comparing Higher LDL-C in Nine Years Follow Up: Cohort Study
Sangmo Hong, Kyungdo Han, Jung Hwan Park, Sung Hoon Yu, Chang Beom Lee, Dong Sun Kim
Journal of Lipid and Atherosclerosis.2023; 12(2): 164. CrossRef
Impact of Allergic Disease on the Risk of Mycobacterial Disease
Taehee Kim, Hayoung Choi, Hyun Lee, Kyungdo Han, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Sang-Heon Kim
The Journal of Allergy and Clinical Immunology: In Practice.2023; 11(9): 2830. CrossRef
Trends in the Prevalence of Blindness and Correlation With Health Status in Korean Adults: A 10-Year Nationwide Population-Based Study
Kyeong Ik Na, Won June Lee, Young Kook Kim
Journal of Korean Medical Science.2023;[Epub] CrossRef
Association between regular physical activity and lower incidence of colorectal cancer in patients with diabetes mellitus: a nationwide cohort study
Han Hee Lee, Kyu‐na Lee, Jin Su Kim, Dae Young Cheung, Hyuk‐Sang Kwon, Bo‐In Lee, Young‐Seok Cho, Soo‐Heon Park, Kyungdo Han, Jin Il Kim
Colorectal Disease.2023; 25(8): 1588. CrossRef
Bovine pericardial versus porcine bioprosthetic mitral valves: results from a Korean Nationwide Cohort Study
Hong Rae Kim, Jino Park, Sung Jun Park, Ho Jin Kim, Seonok Kim, Ye-Jee Kim, Jung-Min Ahn, Dae-Hee Kim, Joon Bum Kim
European Journal of Cardio-Thoracic Surgery.2023;[Epub] CrossRef
Examining the factors associated with inpatients’ perception of overtreatment in Korea: a cross-sectional study
Jin Su Jang, Hyun Woo Jung
BMC Health Services Research.2023;[Epub] CrossRef
Long-term clinical outcomes of tricuspid valve replacement using bovine versus porcine valves: a nationwide population-based study
Suk Ho Sohn, Yoonjin Kang, Ji Seong Kim, Ho Young Hwang, Kyung Hwan Kim, Jae Woong Choi
European Journal of Cardio-Thoracic Surgery.2023;[Epub] CrossRef
Association of physical activity with total and cause-specific mortality in patients with diabetes: A nationwide population-based cohort study
Inha Jung, Kyung-Do Han, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Diabetes Research and Clinical Practice.2023; 202: 110819. CrossRef
The Association Between Institutional Case Volume of Hematopoietic Stem Cell Transplantation and Mortality
Leerang Lim, Eun Jin Jang, Jun Woo Jo, Junghoon Shin, Hyobin Lee, Hannah Lee, Seung-Young Oh, Hyunjae Im, Ho Geol Ryu
Transplantation Proceedings.2023; 55(7): 1715. CrossRef
Association between periodontal disease status and risk of atrial fibrillation: a nationwide population-based cohort study
Jung-Hyun Park, Hyungwoo Lee, Jin-Woo Kim, Tae-Jin Song
BMC Oral Health.2023;[Epub] CrossRef
Trends in the incidence and prevalence of dysphagia requiring medical attention among adults in South Korea, 2006–2016: A nationwide population study
SuYeon Kwon, Seungwoo Cha, Junsik Kim, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim, Sina Azadnajafabad
PLOS ONE.2023; 18(6): e0287512. CrossRef
Socioeconomic Disparities in the Association Between All-Cause Mortality and Health Check-Up Participation Among Healthy Middle-Aged Workers: A Nationwide Study
Byungyoon Yun, Juyeon Oh, Jaesung Choi, Laura S. Rozek, Heejoo Park, Juho Sim, Yangwook Kim, Jongmin Lee, Jin-Ha Yoon
Journal of Korean Medical Science.2023;[Epub] CrossRef
Association between smoking status and death from COVID-19 in South Korea: A nationwide cohort study
Jae Woo Choi
Tobacco Induced Diseases.2023; 21(July): 1. CrossRef
A cohort study found a high risk of end-stage kidney disease associated with acromegaly
Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
Kidney International.2023; 104(4): 820. CrossRef
Comparative cardiovascular outcomes in type 2 diabetes patients taking dapagliflozin versus empagliflozin: a nationwide population-based cohort study
Jaehyun Lim, You-Jung Choi, Bong Sung Kim, Tae-Min Rhee, Hyun-Jung Lee, Kyung-Do Han, Jun-Bean Park, Jin Oh Na, Yong-Jin Kim, Heesun Lee, Hyung-Kwan Kim
Cardiovascular Diabetology.2023;[Epub] CrossRef
Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study
Donghee Kwak, Seok-joo Moon, Jong Woong Park, Duk Hee Lee, Jung Il Lee
Orthopaedic Journal of Sports Medicine.2023;[Epub] CrossRef
Incident dementia in kidney transplantation recipients: a matched comparative nationwide cohort study in South Korea
Seon Ha Baek, Jina Park, Sehoon Park, Mi-yeon Yu, Ji Eun Kim, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Kidney Research and Clinical Practice.2023; 42(4): 519. CrossRef
Developing Operational Definitions Related toHelicobacter pyloriEradication Therapy
Chan Hyuk Park, Sun-Young Jung, Ju Won Lee, Hyo-Joon Yang, Joon Sung Kim, Beom Jin Kim, Soo In Choi, Seung In Seo, Joongyub Lee, Jae Gyu Kim
Journal of Korean Medical Science.2023;[Epub] CrossRef
Fracture Risk in Middle-Aged and Older Patients With Inflammatory Bowel Disease: A Korean Nationwide Population-Based Cohort Study
Ji Min Lee, Kyungdo Han, Kang-Moon Lee, Jae-Seung Yun
Journal of Korean Medical Science.2023;[Epub] CrossRef
Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea
Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Jae Won Hong, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
European Journal of Endocrinology.2023; 189(2): 225. CrossRef
Proton pump inhibitor use and the risk of metachronous gastric cancer after H. pylori eradication in patients who underwent endoscopic resection for gastric neoplasms: A population‐based cohort study
Eun Jeong Gong, Hye‐Kyung Jung, Bora Lee, Jitaek Hong, Jong Wook Kim, Cheol Min Shin, Young Hoon Youn, Kwang Jae Lee
Alimentary Pharmacology & Therapeutics.2023; 58(7): 668. CrossRef
National Trends in Rotavirus Enteritis among Infants in South Korea, 2010–2021: A Nationwide Cohort
Hyun Jee Lee, Yujin Choi, Jaeyu Park, Yong-Sung Choi, Dong Keon Yon, Do Hyun Kim
Children.2023; 10(9): 1436. CrossRef
Impact of Concomitant Use of Proton Pump Inhibitors and Clopidogrel on Recurrent Stroke and Myocardial Infarction
Yong Kang Lee, Hyun Sun Lim, Youn I Choi, Eun Ju Choe, Seonji Kim, Seng Chan You, Kyung Joo Lee, Yerim Kim, Da Hee Park, Woon Geon Shin, Seung In Seo
Pharmaceuticals.2023; 16(9): 1213. CrossRef
Uric Acid and Risk of Cardiovascular Disease and Mortality: A Longitudinal Cohort Study
Jae Young Kim, Changhwan Seo, Haeyong Pak, Hyunsun Lim, Tae Ik Chang
Journal of Korean Medical Science.2023;[Epub] CrossRef
Occupational characteristics and risk factors associated with endometriosis among Korean female workers
Seunghyun Lee, Seung-Yeon Lee, Wanhyung Lee, Federico Romano
PLOS ONE.2023; 18(10): e0292362. CrossRef
Suicidal Thinking Among Patients With Spinal Conditions in South Korea: A Population-Based Cross-Sectional Study
Tak Kyu Oh, Hye Yoon Park, In-Ae Song
Psychiatry Investigation.2023; 20(9): 834. CrossRef
Increased risk of venous and arterial thromboembolism in patients with colorectal cancer receiving cetuximab-based combination chemotherapy: A population-based study in Korea
Ho-Young Yhim, Juhyun Lee, Kyoung Ha Kim, Sang-A Kim, Ji Yun Lee, Hun-Gyu Hwang, Junshik Hong, Jeong-Ok Lee, Soo-Mee Bang
Thrombosis Research.2023; 231: 50. CrossRef
Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea
Ga Hee Kim, Hyungchul Park, Kee Wook Jung, Min-Ju Kim, Ye-Jee Kim, Ji Min Lee, Bong Eun Lee, Yang Won Min, Jeong Hwan Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hyun Jin Kim
Gut and Liver.2023; 17(6): 894. CrossRef
Differential Impact of Obesity on the Risk of Diabetes Development in Two Age Groups: Analysis from the National Health Screening Program
Tae Kyung Yoo, Kyung-Do Han, Yang-Hyun Kim, Ga Eun Nam, Sang Hyun Park, Eun-Jung Rhee, Won-Young Lee
Diabetes & Metabolism Journal.2023; 47(6): 846. CrossRef
Association between preoperative modifiable lifestyle factors and mortality after cancer surgery: a population-based cohort study in South Korea
Tak Kyu Oh, In-Ae Song
Annals of Surgical Treatment and Research.2023; 105(4): 179. CrossRef
Classification of long-term clinical course of Parkinson’s disease using clustering algorithms on social support registry database
Dougho Park, Su Yun Lee, Jong Hun Kim, Hyoung Seop Kim
Journal of Big Data.2023;[Epub] CrossRef
Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study
Hyungwoo Lee, Moo-Suk Park, Min Kyoung Kang, Tae-Jin Song
Journal of Personalized Medicine.2023; 13(9): 1414. CrossRef
Association of physical activity with the risk of Parkinson's disease in depressive disorder: A nationwide longitudinal cohort study
Ji hyun An, Kyung-do Han, Jin-Hyung Jung, Hong Jin Jeon
Journal of Psychiatric Research.2023; 167: 93. CrossRef
Effect of changes in the hearing aid subsidy on the prevalence of hearing loss in South Korea
Chul Young Yoon, Junhun Lee, Tae Hoon Kong, Young Joon Seo
Frontiers in Neurology.2023;[Epub] CrossRef
Preoperative Body Mass Index, Waist Circumference, and Mortality After Major Cancer Surgery: A Nationwide Cohort Study in Korea
Tak Kyu Oh, In-Ae Song
Journal of Korean Medical Science.2023;[Epub] CrossRef
Characteristics and risk factors of suicide among people who attempted self-harm in South Korea: A longitudinal National Cohort Study in South Korea
Hye Hyeon Kim, Jin Hyuk Lee, In Han Song, Yu Rang Park
Psychiatry Research.2023; 330: 115613. CrossRef
Association Between Premature Menopause and Cardiovascular Diseases and All‐Cause Mortality in Korean Women
Gyu Bae Lee, Ga Eun Nam, Wonsock Kim, Byoungduck Han, Kyung Hwan Cho, Seon Mee Kim, Youn Seon Choi, Do Hoon Kim, Yong‐Gyu Park, Jin‐Hyung Jung, Kyungdo Han, Yang‐Hyun Kim
Journal of the American Heart Association.2023;[Epub] CrossRef
Risk of gastric cancer among long-term proton pump inhibitor users: a population-based cohort study
Jong Wook Kim, Hye-Kyung Jung, Bora Lee, Cheol Min Shin, Eun Jeong Gong, Jitaek Hong, Young Hoon Youn, Kwang Jae Lee
European Journal of Clinical Pharmacology.2023; 79(12): 1699. CrossRef
Cancer Risk in Elderly Korean Patients with Neurodegenerative Disease and its relation to Type 2 Diabetes
Hee-Cheol Kim, Ji-Hun Kim, Ho-Jun Lee, Yang-Tae Kim, Byeong-Churl Jang
The Open Neurology Journal.2023;[Epub] CrossRef
Performance of Cardiovascular Risk Prediction Models in Korean Patients With New‐Onset Rheumatoid Arthritis: National Cohort Study
Jae Hyun Kim, Gaeun Lee, Jinseub Hwang, Ji‐Won Kim, Jin‐Won Kwon, Yun‐Kyoung Song
Journal of the American Heart Association.2023;[Epub] CrossRef
Impact of Propofol-based Total Intravenous Anesthesia Versus Inhalation Anesthesia on Long-term Survival After Cancer Surgery in a Nationwide Cohort
Susie Yoon, Sun-Young Jung, Myo-Song Kim, Danbi Yoon, Younghae Cho, Yunseok Jeon
Annals of Surgery.2023; 278(6): 1024. CrossRef
Decreased Risk of Knee Osteoarthritis with Taller Height in an East Asian Population: A Nationwide Cohort Study
Dong Hwan Lee, Hwa Sung Lee, Soo Hyun Jang, Jun-Young Heu, Kyungdo Han, Se-Won Lee
Journal of Clinical Medicine.2023; 13(1): 92. CrossRef
Cost-effectiveness of the anti-vascular endothelial growth factor intravitreal injection and panretinal photocoagulation for patients with proliferative diabetic retinopathy in South Korea
Hyeon-Jeong Lee, Songhee Cho, Jungeun Park, Yan Jin, Hyung Min Kim, Donghyun Jee
BMC Health Services Research.2023;[Epub] CrossRef
Prior Evaluation of Nutritional Status and Mortality in Patients with Sepsis in South Korea
Tak Kyu Oh, In-Ae Song
Nutrients.2023; 15(24): 5040. CrossRef
Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
Endocrinology and Metabolism.2023; 38(6): 690. CrossRef
Proton Pump Inhibitor Co-Therapy in Patients with Atrial Fibrillation Treated with Oral Anticoagulants and a Prior History of Upper Gastrointestinal Tract Bleeding
So-Ryoung Lee, Soonil Kwon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip
Cardiovascular Drugs and Therapy.2022; 36(4): 679. CrossRef
Institutional case volume-incorporated mortality risk prediction model for cardiac surgery
Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongnyeok Park, Ho Geol Ryu
Asian Journal of Surgery.2022; 45(1): 189. CrossRef
Does Surgical Ablation of Atrial Fibrillation Benefit Patients Undergoing Bioprosthetic Valve Replacement?
Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
Seminars in Thoracic and Cardiovascular Surgery.2022; 34(3): 906. CrossRef
Burden of comorbidities and medication use in childbearing women with rheumatic diseases: a nationwide population-based study
Min Kyung Chung, Chan Hee Lee, Jin Su Park, Hyunsun Lim, Jisoo Lee
The Korean Journal of Internal Medicine.2022; 37(6): 1250. CrossRef
Validation of Dynamic Aspartate‐to–Alanine Aminotransferase Ratio for Predicting Liver Disease Mortality
In‐Ae Song, Eun Sun Jang, Tak Kyu Oh
Hepatology Communications.2022; 6(4): 740. CrossRef
Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
Chan Joo Lee, Ji-Yeon Lee, Kyungdo Han, Da Hye Kim, Hanna Cho, Kwang Joon Kim, Eun Seok Kang, Bong-Soo Cha, Yong-ho Lee, Sungha Park
Hypertension.2022; 79(1): 218. CrossRef
Continuing regular physical activity and maintaining body weight have a synergistic interaction in improving survival: a population-based cohort study including 6.5 million people
Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak
European Journal of Preventive Cardiology.2022; 29(3): 547. CrossRef
Liver enzymes and risk of ocular motor cranial nerve palsy: a nationwide population-based study
Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
Neurological Sciences.2022; 43(5): 3395. CrossRef
Underutilisation of prophylactic G-CSF in breast cancer patients receiving adjuvant docetaxel/cyclophosphamide chemotherapy
Minhee Ku, Nam Kyung Je
Journal of Chemotherapy.2022; 34(8): 534. CrossRef
Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
Bum Sik Tae, Young Eun Yoon, Woong Na, Kyung Jin Oh, Sung Yul Park, Jae Young Park, Hong Sang Moon
Investigative and Clinical Urology.2022; 63(1): 92. CrossRef
Acromegaly and cardiovascular outcomes: a cohort study
Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
European Heart Journal.2022; 43(15): 1491. CrossRef
Pericardial Versus Porcine Valves for Surgical Aortic Valve Replacement
Hong Ju Shin, Wan Kee Kim, Jin Kyoung Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
Korean Circulation Journal.2022; 52(2): 136. CrossRef
Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study
Changil Choi, Jong Keun Kim, Kyungdo Han, Young Goo Lee, Jun Hyun Han
Investigative and Clinical Urology.2022; 63(1): 63. CrossRef
Comprehensive risk assessment for hospital-acquired pneumonia: sociodemographic, clinical, and hospital environmental factors associated with the incidence of hospital-acquired pneumonia
Bo-Guen Kim, Minwoong Kang, Jihyun Lim, Jin Lee, Danbee Kang, Minjung Kim, Jinhee Kim, Hyejeong Park, Kyung Hoon Min, Juhee Cho, Kyeongman Jeon
BMC Pulmonary Medicine.2022;[Epub] CrossRef
Metabolic Disease Incidence After Allogeneic Stem Cell Transplantation: A Nationwide Korean Case-Control Study
Jeonghoon Ha, See Hyun Park, Sung-Soo Park, Seunghoon Han
The Journal of Clinical Endocrinology & Metabolism.2022; 107(4): 943. CrossRef
Development of eClaim system for private indemnity health insurance in South Korea: Compatibility and interoperability
Sungchul Bae, Byoung-Kee Yi
Health Informatics Journal.2022;[Epub] CrossRef
Incidence of Depression after Traumatic Brain Injury: A Nationwide Longitudinal Study of 2.2 Million Adults
Yoonjeong Choi, Eun Young Kim, Jiyu Sun, Han-Kyoul Kim, Ye Seol Lee, Byung-Mo Oh, Hye Yoon Park, Ja-Ho Leigh
Journal of Neurotrauma.2022; 39(5-6): 390. CrossRef
Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
Biomedicines.2022; 10(2): 303. CrossRef
Clinical outcomes of early closure versus conservative strategy after diagnosis with atrial septal defect: a nationwide population-based cohort study
Sun-Yang Min, Ji Sung Lee, Duk-Woo Park, Jong-Min Song
European Journal of Cardio-Thoracic Surgery.2022;[Epub] CrossRef
Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea
Gyeongsil Lee, Seulggie Choi, Yoosun Cho, Sang Min Park
Clinical Nutrition Research.2022; 11(1): 32. CrossRef
Long-term prognosis and causes of death among survivors after out-of-hospital cardiac arrest: A population-based longitudinal study
Yongil Cho, Jaehoon Oh, Jeong-Hun Shin, Byung Sik Kim, Jin-Kyu Park, Jun Ho Lee, Jae Hwan Kim, Minae Park
Resuscitation.2022; 173: 31. CrossRef
Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study
Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim, Kyungdo Han, Jin-hyung Jung, Do Hoon Kim, Joo-Hyun Park
Scientific Reports.2022;[Epub] CrossRef
Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Ji-Yeon Lee, Young-eun Kim, Kyungdo Han, Eugene Han, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
JAMA Network Open.2022; 5(2): e220262. CrossRef
Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
Endocrinology and Metabolism.2022; 37(1): 148. CrossRef
Non-Alcoholic Fatty Liver Disease Defined by Fatty Liver Index and Incidence of Heart Failure in the Korean Population: A Nationwide Cohort Study
Byoungduck Han, Gyu Bae Lee, Sun Young Yim, Kyung-Hwan Cho, Koh Eun Shin, Jung-Hwan Kim, Yong-Gyu Park, Kyung-Do Han, Yang-Hyun Kim
Diagnostics.2022; 12(3): 663. CrossRef
Contact with the health care system prior to suicide: A nationwide population-based analysis using linkage national death certificates and national health insurance data
Eun Jee Park, Nam Ju Ji, Weon Young Lee
Journal of Psychiatric Research.2022; 149: 226. CrossRef
Association between asthma or chronic obstructive pulmonary disease and chronic otitis media
Sung Kyun Kim, Seok Jin Hong, Dae Myoung Yoo, Chanyang Min, Hyo Geun Choi
Scientific Reports.2022;[Epub] CrossRef
Prognosis of pregnancy after breast cancer diagnosis according to the type of treatment: A population-based study in Korea by the SMARTSHIP group
Soo Youn Bae, Jihyoun Lee, Ji Sung Lee, Jae Sun Yoon, Ku Sang Kim, Yoo Seok Kim, Zisun Kim, Jun Won Min, Eun-Jung Shim, Ilkyun Lee, Min Hyuk Lee, Sungmin Park
The Breast.2022; 63: 46. CrossRef
Fracture risk and impact of osteoporosis in patients with Parkinson’s disease: a nationwide database study
Tae-lim Kim, Seong Jun Byun, Min Yong Seong, Byung-Mo Oh, Sang Jun Park, Han Gil Seo
Journal of Bone and Mineral Metabolism.2022; 40(4): 602. CrossRef
Risk prediction models incorporating institutional case volume for mortality after hip fracture surgery in the elderly
Seokha Yoo, Eun Jin Jang, Junwoo Jo, Hannah Lee, Yoonbin Hwang, Ho Geol Ryu
Archives of Orthopaedic and Trauma Surgery.2022; 143(5): 2307. CrossRef
Association of weight change following smoking cessation with the risk of tuberculosis development: A nationwide population-based cohort study
Seung Hoon Kim, Yong-Moon Park, Kyungdo Han, Seung Hyun Ko, Shin Young Kim, So Hyang Song, Chi Hong Kim, Kyu Yeon Hur, Sung Kyoung Kim, Juan F. Orueta
PLOS ONE.2022; 17(4): e0266262. CrossRef
Epidemiology of Acute Leukemia among Children with Down Syndrome in Korea
Young Bae Choi, Keon Hee Yoo
Cancer Research and Treatment.2022; 54(2): 572. CrossRef
The Effect of Alcohol Drinking on Metabolic Syndrome and Obesity in Koreans: Big Data Analysis
Eun Jung Park, Hye Jung Shin, Sung Soo Kim, Ki Eun Kim, Sun Hyun Kim, Youl Ri Kim, Kyong Mee Chung, Kyung Do Han
International Journal of Environmental Research and Public Health.2022; 19(9): 4949. CrossRef
Prolonged or Transition to Metabolically Unhealthy Status, Regardless of Obesity Status, Is Associated with Higher Risk of Cardiovascular Disease Incidence and Mortality in Koreans
Juhee Lee, So-Young Kwak, Dahyun Park, Ga-Eun Kim, Clara Yongjoo Park, Min-Jeong Shin
Nutrients.2022; 14(8): 1644. CrossRef
Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects
Byung Kyu Park, Jeong Hun Seo, Jae Bock Chung, Jung Kyu Choi
British Journal of Cancer.2022; 127(3): 549. CrossRef
Cardiovascular Risk and Treatment Outcomes in Severe Hypercholesterolemia: A Nationwide Cohort Study
Chan Joo Lee, Sanghyun Park, Kyungdo Han, Sang‐Hak Lee
Journal of the American Heart Association.2022;[Epub] CrossRef
Association between Smoking Status and Incident Non-Cystic Fibrosis Bronchiectasis in Young Adults: A Nationwide Population-Based Study
Bumhee Yang, Kyungdo Han, Bongseong Kim, Hyung Koo Kang, Jung Soo Kim, Eung-Gook Kim, Hayoung Choi, Hyun Lee
Journal of Personalized Medicine.2022; 12(5): 691. CrossRef
Clinical Indication of Aspirin Associated With Reduced Risk of Liver Cancer in Chronic Hepatitis B: A Nationwide Cohort Study
Byungyoon Yun, Sang Hoon Ahn, Jin-Ha Yoon, Beom Kyung Kim
American Journal of Gastroenterology.2022; 117(5): 758. CrossRef
Association between Attention Deficit Hyperactivity Disorder Medication and Depression: A 10-year Follow-up Self-controlled Case Study
Yunhye Oh, Yoo-Sook Joung, Jinseob Kim
Clinical Psychopharmacology and Neuroscience.2022; 20(2): 320. CrossRef
Association of Chronic Hepatitis B Infection and Antiviral Treatment With the Development of the Extrahepatic Malignancies: A Nationwide Cohort Study
Dong Hyeon Lee, Sung Won Chung, Jeong-Hoon Lee, Hwi Young Kim, Goh Eun Chung, Mi-Sook Kim, Bo Ram Yang, Joon Yeul Nam, Yun Bin Lee, Yoon Jun Kim, Jung-Hwan Yoon
Journal of Clinical Oncology.2022; 40(29): 3394. CrossRef
Cancer risk in the residents of a town near three industrial waste incinerators in Korea: a retrospective cohort study
Kyung-Hwa Choi, Hyungryul Lim, Sanghyuk Bae, Mina Ha, Ho-Jang Kwon, Mira Yoon, Seonmi Hong, Sang-Yong Eom, Yong-Dae Kim, Heon Kim
International Archives of Occupational and Environmental Health.2022; 95(9): 1829. CrossRef
Triglyceride-Glucose Index Is a Useful Marker for Predicting Future Cardiovascular Disease and Mortality in Young Korean Adults: A Nationwide Population-Based Cohort Study
Yun Kyung Cho, Kyung-do Han, Hwi Seung Kim, Chang Hee Jung, Joong-Yeol Park, Woo Je Lee
Journal of Lipid and Atherosclerosis.2022; 11(2): 178. CrossRef
Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
Min Seok Baek, Han-Kyeol Kim, Kyungdo Han, Hyuk-Sung Kwon, Han Kyu Na, Chul Hyoung Lyoo, Hanna Cho
Frontiers in Neurology.2022;[Epub] CrossRef
Risk Factors of Incident Lung Cancer in Patients with Non-Cystic Fibrosis Bronchiectasis: A Korean Population-Based Study
Youlim Kim, Kyungdo Han, Juhwan Yoo, Hyung Koo Kang, Tai Sun Park, Dong Won Park, Ji Young Hong, Ji-Yong Moon, Sang-Heon Kim, Tae Hyung Kim, Kwang Ha Yoo, Jang Won Sohn, Ho Joo Yoon, Hayoung Choi, Hyun Lee
Cancers.2022; 14(11): 2604. CrossRef
Association Between Hypertension and Incident Infective Endocarditis
Gyu Bae Lee, Koh Eun Shin, Kyungdo Han, Ho-Sung Son, Jae-Seung Jung, Yang-Hyun Kim, Hee-Jung Kim
Hypertension.2022; 79(7): 1466. CrossRef
Risk of secondary nonhematologic malignancies after allogeneic stem cell transplantation: A nationwide case‐control cohort study
Sung‐Soo Park, Si‐Hyun Park, Seunghoon Han
International Journal of Cancer.2022; 151(7): 1024. CrossRef
Acute myocardial infarction risk in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea
Eun Bin Cho, Yohwan Yeo, Jin-Hyung Jung, Su-Min Jeong, Kyungdo Han, Jeong Hoon Yang, Dong Wook Shin, Ju-Hong Min
Multiple Sclerosis Journal.2022; 28(12): 1849. CrossRef
Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim
Scientific Reports.2022;[Epub] CrossRef
Association between migraine and risk of ocular motor cranial nerve palsy
Soolienah Rhiu, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
Scientific Reports.2022;[Epub] CrossRef
Statin use and risk of progression to liver cirrhosis in chronic hepatitis B independent of conventional risk factors: A nationwide study
Byungyoon Yun, Sang Hoon Ahn, Jin‐Ha Yoon, Beom Kyung Kim
Hepatology Communications.2022; 6(9): 2455. CrossRef
Association Between Metabolic Syndrome and the Risk of Colorectal Cancer Diagnosed Before Age 50 Years According to Tumor Location
Eun Hyo Jin, Kyungdo Han, Dong Ho Lee, Cheol Min Shin, Joo Hyun Lim, Yoon Jin Choi, Kichul Yoon
Gastroenterology.2022; 163(3): 637. CrossRef
A positive faecal immunochemical test result and its association with the incidence of rheumatoid arthritis, systemic lupus erythematosus, and psoriatic arthritis: an analysis of one-million national colorectal cancer screening programme results
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sung Soo Ahn
BMC Medicine.2022;[Epub] CrossRef
Obesity Fact Sheet in Korea, 2021: Trends in Obesity Prevalence and Obesity-Related Comorbidity Incidence Stratified by Age from 2009 to 2019
Ye Seul Yang, Byoung-Duck Han, Kyungdo Han, Jin-Hyung Jung, Jang Won Son
Journal of Obesity & Metabolic Syndrome.2022; 31(2): 169. CrossRef
Venous Thromboembolism Risk in Asian Patients with Inflammatory Bowel Disease: A Population-Based Nationwide Inception Cohort Study
Su Young Kim, Yeon Seo Cho, Hyun-Soo Kim, Jung Kuk Lee, Hee Man Kim, Hong Jun Park, Hyunil Kim, Jihoon Kim, Dae Ryong Kang
Gut and Liver.2022; 16(4): 555. CrossRef
Impact of Wildfire Smoke Exposure on Health in Korea
Kihyun Lee, Sung-Soo Oh, Kyoung Sook Jeong, Yeon-Soon Ahn, Sei Jin Chang, Se Hwa Hong, Dae Ryong Kang, Sung-Kyung Kim, Sang-Baek Koh
Yonsei Medical Journal.2022; 63(8): 774. CrossRef
Risk for Behçet’s disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea
Yeong Ho Kim, Hyun Jee Kim, Jin Woo Park, Kyung Do Han, Yong Gyu Park, Young Bok Lee, Ji Hyun Lee
Scientific Reports.2022;[Epub] CrossRef
Analysis of Mortality in Intracerebral Hemorrhage Patients with Hyperacute Ischemic Stroke Treated Using Thrombolytic Therapy: A Nationwide Population-based Cohort Study in South Korea
Hyun-Young Choi, Yongil Cho, Wonhee Kim, Yang-Ki Minn, Gu-Hyun Kang, Yong-Soo Jang, Yoonje Lee, Jae-Guk Kim, Jihoon Kim, Youngsuk Cho, Hyungoo Shin, Shinje Moon, Chiwon Ahn, Juncheol Lee, Dong-Geum Shin, Jae-Keun Park
Journal of Personalized Medicine.2022; 12(8): 1260. CrossRef
Institutional case volume and mortality after aortic and mitral valve replacement: a nationwide study in two Korean cohorts
Karam Nam, Eun Jin Jang, Jun Woo Jo, Jiwon You, Jung-Bin Park, Ho Geol Ryu
Journal of Cardiothoracic Surgery.2022;[Epub] CrossRef
Effect of metabolic dysfunction‐associated fatty liver disease on liver cancer risk in a population with chronic hepatitis B virus infection: A nationwide study
Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin‐Ha Yoon, Beom Kyung Kim
Hepatology Research.2022; 52(12): 975. CrossRef
Non–Cystic Fibrosis Bronchiectasis Increases the Risk of Lung Cancer Independent of Smoking Status
Hayoung Choi, Hye Yun Park, Kyungdo Han, Juhwan Yoo, Sun Hye Shin, Bumhee Yang, Youlim Kim, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Seung Won Ra, Sang-Heon Kim, Tae-Hyung Kim, Yeon-Mok Oh, Ho Joo Yoon, Jang Won Sohn, Hyun Lee
Annals of the American Thoracic Society.2022; 19(9): 1551. CrossRef
Real-World Prescription Patterns and Barriers Related to the Use of Sodium-Glucose Cotransporter 2 Inhibitors among Korean Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease
Jong Ha Baek, Ye Seul Yang, Seung-Hyun Ko, Kyung Do Han, Jae Hyeon Kim, Min Kyong Moon, Jong Suk Park, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Jong Han Choi, Kyu Yeon Hur
Diabetes & Metabolism Journal.2022; 46(5): 701. CrossRef
Editor's Choice – Effect of Physical Activity and Tobacco Use on Mortality and Morbidity in Patients with Peripheral Arterial Disease After Revascularisation: A Korean Nationwide Population Based Cohort Study
Seungwoo Cha, Sherry L. Grace, Kyungdo Han, Bongseong Kim, Nam-Jong Paik, Won-Seok Kim
European Journal of Vascular and Endovascular Surgery.2022; 64(4): 417. CrossRef
Augmented risk of ischemic stroke in hypertrophic cardiomyopathy patients without documented atrial fibrillation
You-Jung Choi, Bongseong Kim, Tae-Min Rhee, Hyun-Jung Lee, Heesun Lee, Jun-Bean Park, Seung-Pyo Lee, Kyung-Do Han, Yong-Jin Kim, Hyung-Kwan Kim
Scientific Reports.2022;[Epub] CrossRef
Depression in patients with inflammatory bowel disease is associated with increased risk of dementia and Parkinson’s disease: A nationwide, population-based study
Kookhwan Choi, Hyun Jung Lee, Kyungdo Han, Seong-Joon Koh, Jong Pil Im, Joo Sung Kim
Frontiers in Medicine.2022;[Epub] CrossRef
Individual socioeconomic status and risk of out‐of‐hospital cardiac arrest: A nationwide case–control analysis
Sun Young Lee, Jeong Ho Park, Young Ho Choi, Jungah Lee, Young Sun Ro, Ki Jeong Hong, Kyoung Jun Song, Sang Do Shin
Academic Emergency Medicine.2022; 29(12): 1438. CrossRef
Impact of nationwide hepatocellular carcinoma surveillance on the prognosis in patients with chronic liver disease
Won Sohn, Danbee Kang, Minwoong Kang, Eliseo Guallar, Juhee Cho, Yong-Han Paik
Clinical and Molecular Hepatology.2022; 28(4): 851. CrossRef
Population Prevalence, Cancer Risk, and Mortality Risk of Turner Syndrome in South Korean Women Based on National Health Insurance Service Data
Sung Eun Kim, Sang Hyun Park, Kyungdo Han, Won Kyoung Cho, Byung-Kyu Suh, Yong-Gyu Park
Yonsei Medical Journal.2022; 63(11): 991. CrossRef
Effects of Endocrine Therapy on Cardiovascular Diseases and Type 2 Diabetes Among Breast Cancer Survivors: The National Health Insurance Service Database of Korea
Ji‐Eun Kim, Jaesung Choi, JooYong Park, Wonshik Han, Daehee Kang, Ji‐Yeob Choi
Journal of the American Heart Association.2022;[Epub] CrossRef
Association between exercise and risk of cardiovascular diseases in patients with non-cystic fibrosis bronchiectasis
Hayoung Choi, Sang Hyuk Kim, Kyungdo Han, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Hyun Lee
Respiratory Research.2022;[Epub] CrossRef
Development and Evaluation of Machine Learning-Based High-Cost Prediction Model Using Health Check-Up Data by the National Health Insurance Service of Korea
Yeongah Choi, Jiho An, Seiyoung Ryu, Jaekyeong Kim
International Journal of Environmental Research and Public Health.2022; 19(20): 13672. CrossRef
Comparing Non-Communicable Disease Risk Factors in Asian Migrants and Native Koreans among the Asian Population
Heng Piao, Jae Moon Yun, Aesun Shin, Belong Cho, Daehee Kang
Biomolecules & Therapeutics.2022; 30(6): 603. CrossRef
Chronic kidney disease as a risk factor for abdominal aortic aneurysm: a nationwide population-based study
Kang-woong Jun, Ju-hwan Yoo, Kyung-jai Ko, Hyung-jin Cho, Mi-hyeong Kim, Kyung-do Han, Jeong-kye Hwang
Annals of Surgical Treatment and Research.2022; 103(5): 297. CrossRef
Epidemiology and Management Trend of Renal Trauma: Results of a Nationwide Population-Based Study
Bum Sik Tae, Hoon Ah Jang, Jihyeong Yu, Kyung-Jin Oh, Kyung Hyun Moon, Jae Young Park
Journal of Korean Medical Science.2022;[Epub] CrossRef
Low-to-moderate atmospheric ozone levels are negatively correlated with hospital visits by asthma patients
Soyeon Lee, Minhyeok Lee
Medicine.2022; 101(45): e31737. CrossRef
Acute Pancreatitis Increases the Risk of Gastrointestinal Cancer in Type 2 Diabetic Patients: A Korean Nationwide Cohort Study
Jin Ho Choi, Woo Hyun Paik, Dong Kee Jang, Min Kyu Kim, Ji Kon Ryu, Yong-Tae Kim, Kyungdo Han, Sang Hyub Lee
Cancers.2022; 14(22): 5696. CrossRef
Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
Diabetes & Metabolism Journal.2022; 46(6): 923. CrossRef
The association between changes in hepatic steatosis and hepatic fibrosis with cardiovascular outcomes and mortality in patients with New-Onset type 2 Diabetes: A nationwide cohort study
Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
Diabetes Research and Clinical Practice.2022; 194: 110191. CrossRef
Long-term outcomes of preterm infants in the first 6 years of life: a nationwide population-based study in Korea
Ju Hyun Jin, Sung Hee Lee, Tae Mi Youk, Shin Won Yoon
European Journal of Pediatrics.2022; 182(2): 641. CrossRef
Risk of malignancy in patients with psoriasis according to treatment modalities in Korea: a nationwide cohort study
Ji Youn Hong, Juhee Ahn, Sungho Won, Sung Min Kim, Young Ah Cho, Chang Yong Kim, Jae Young Sung, Da-Ae Yu, Yang Won Lee, Yong Beom Choe
Scientific Reports.2022;[Epub] CrossRef
Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort study
Hyunsuk Kim, Mun Jung Ko, Chi-Yeon Lim, Eunjin Bae, Young Youl Hyun, Sungjin Chung, Soon Hyo Kwon, Jang-Hee Cho, Kyung Don Yoo, Woo Yeong Park, In O Sun, Byung Chul Yu, Gang-Jee Ko, Jae Won Yang, Won Min Hwang, Sang Heon Song, Sung Joon Shin, Yu Ah Hong
BMC Geriatrics.2022;[Epub] CrossRef
The associations between changes in hepatic steatosis and heart failure and mortality: a nationwide cohort study
Jiyun Park, Gyuri Kim, Hasung Kim, Jungkuk Lee, Sang-Man Jin, Jae Hyeon Kim
Cardiovascular Diabetology.2022;[Epub] CrossRef
Incidence of edentulism among older adults using the Korean National Health Insurance Service database, 2013-2018
Hyeonjeong Go, Eun-Kyong Kim, Hoi-In Jung, Song Vogue Ahn, Hosung Shin, Atsuo Amano, Youn-Hee Choi
Epidemiology and Health.2022; 44: e2022091. CrossRef
Risk of Neurodegenerative Diseases in Patients With Acromegaly
Sangmo Hong, Kyungdo Han, Kyung-Soo Kim, Cheol-Young Park
Neurology.2022;[Epub] CrossRef
Association between Body Mass Index and Risk of Coronavirus Disease 2019 (COVID-19): A Nationwide Case-control Study in South Korea
Chan-Young Jung, Haeyong Park, Dong Wook Kim, Hyunsun Lim, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim, Tae Ik Chang
Clinical Infectious Diseases.2021; 73(7): e1855. CrossRef
Increased risk of cancer in patients with retinal vein occlusion: a 12-year nationwide cohort study
Min Seok Kim, Joon Hee Cho, Seong Jun Byun, Chang-Mo Oh, Kyu Hyung Park, Sang Jun Park
British Journal of Ophthalmology.2021; 105(12): 1705. CrossRef
Conditional relative survival and competing mortality in patients who underwent surgery for lung cancer: A nationwide cohort study
Jung Eun Yoo, Kyungdo Han, Dong Wook Shin, Sang Hyun Park, In Young Cho, Dong Woog Yoon, Jongho Cho, Kyu‐Won Jung
International Journal of Cancer.2021; 148(3): 626. CrossRef
Impact of Benign Prostatic Hyperplasia and/or Prostatitis on the Risk of Prostate Cancer in Korean Patients
Sung Han Kim, Whi-An Kwon, Jae Young Joung
The World Journal of Men's Health.2021; 39(2): 358. CrossRef
High prevalence of physical inactivity after heart valve surgery and its association with long-term mortality: A nationwide cohort study
Sun-Hyung Kim, Seungwoo Cha, Seongmin Kang, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim
European Journal of Preventive Cardiology.2021; 28(7): 749. CrossRef
Risk of cancer incidence in patients with idiopathic pulmonary fibrosis: A nationwide cohort study
Hong Yeul Lee, Jinwoo Lee, Chang‐Hoon Lee, Kyungdo Han, Sun Mi Choi
Respirology.2021; 26(2): 180. CrossRef
Association of physical activity with all-cause and cardiovascular mortality in 7666 adults with hypertrophic cardiomyopathy (HCM): more physical activity is better
Soonil Kwon, Hyun-Jung Lee, Kyung-Do Han, Da Hye Kim, Seung-Pyo Lee, In-Chang Hwang, Yeonyee Yoon, Jun-Bean Park, Heesun Lee, Soongu Kwak, Seokhun Yang, Goo-Yeong Cho, Yong-Jin Kim, Hyung-Kwan Kim, Steve R Ommen
British Journal of Sports Medicine.2021; 55(18): 1034. CrossRef
Traditional medicine for the treatment of common cold in Korean adults: A nationwide population-based study
Hyungtae Kim, Jun-Yong Choi, Minna Hong, Hae Sun Suh
Integrative Medicine Research.2021; 10(1): 100458. CrossRef
Physical activity after ischemic stroke and its association with adverse outcomes: A nationwide population-based cohort study
Seong-Min Kang, Sun-Hyung Kim, Kyung-Do Han, Nam-Jong Paik, Won-Seok Kim
Topics in Stroke Rehabilitation.2021; 28(3): 170. CrossRef
Obesity and breast cancer risk for pre- and postmenopausal women among over 6 million Korean women
Jae Won Park, Kyungdo Han, Dong Wook Shin, Yohwan Yeo, Ji Won Chang, Jung Eun Yoo, Su-Min Jeong, Se-Kyung Lee, Jai Min Ryu, Yong-Moon Park
Breast Cancer Research and Treatment.2021; 185(2): 495. CrossRef
Association of Hypertension With the Risk and Severity of Epistaxis
Hayoung Byun, Jae Ho Chung, Seung Hwan Lee, Jiin Ryu, Changsun Kim, Jeong-Hun Shin
JAMA Otolaryngology–Head & Neck Surgery.2021; 147(1): 34. CrossRef
The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur
Bone.2021; 142: 115691. CrossRef
Increased atrial fibrillation risk in Parkinson’s disease: A nationwide population‐based study
Seokmoon Han, Inki Moon, Eue‐Keun Choi, Kyung‐Do Han, Hae‐Chan Cho, Seo‐Young Lee, Seokhun Yang, Soonil Kwon, You‐jung Choi, Hyun‐Jung Lee, Euijae Lee, So‐Ryung Lee, Seil Oh
Annals of Clinical and Translational Neurology.2021; 8(1): 238. CrossRef
Risk of Cancer Following the Use of N-Nitrosodimethylamine (NDMA) Contaminated Ranitidine Products: A Nationwide Cohort Study in South Korea
Hong Jin Yoon, Jie-Hyun Kim, Gi Hyeon Seo, Hyojin Park
Journal of Clinical Medicine.2021; 10(1): 153. CrossRef
The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
Sangmo Hong, Kyungdo Han, Cheol-Young Park
Alzheimer's Research & Therapy.2021;[Epub] CrossRef
Ten-Year Relative Survival From the Diagnosis of Parkinson's Disease: A Nationwide Database Study
Han Gil Seo, Seong Jun Byun, Byung-Mo Oh, Sang Jun Park
Journal of the American Medical Directors Association.2021; 22(8): 1757. CrossRef
Short- and long-term exposure to air pollution and lack of sunlight are associated with an increased risk of depression: A nested case-control study using meteorological data and national sample cohort data
So Young Kim, Minji Bang, Jee Hye Wee, Chanyang Min, Dae Myoung Yoo, Sang-Min Han, Seungdo Kim, Hyo Geun Choi
Science of The Total Environment.2021; 757: 143960. CrossRef
Associations between metabolic syndrome and type of dementia: analysis based on the National Health Insurance Service database of Gangwon province in South Korea
Yeo Jin Kim, Sang Mi Kim, Dae Hyun Jeong, Sang-Kyu Lee, Moo-Eob Ahn, Ohk-Hyun Ryu
Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef
Repeatedly elevated γ-glutamyltransferase levels are associated with an increased incidence of digestive cancers: A population-based cohort study
Chang-Hoon Lee, Kyungdo Han, Da Hye Kim, Min-Sun Kwak
World Journal of Gastroenterology.2021; 27(2): 176. CrossRef
Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: A nationwide population-based study
Min Kyung Chung, Jin Su Park, Hyunsun Lim, Chan Hee Lee, Jisoo Lee
Lupus.2021; 30(4): 674. CrossRef
Effect of institutional case volume on mid-term mortality after coronary artery bypass grafting surgery
Seohee Lee, Eun Jin Jang, Junwoo Jo, Dongyeon Jang, Bo Rim Kim, Ho Geol Ryu
General Thoracic and Cardiovascular Surgery.2021; 69(9): 1275. CrossRef
Rheumatoid arthritis in low‐level toluene‐exposed workers based on nationwide medical surveillance data in Korea
Young‐Sun Min, Sungho Lee, Mingi Kim, Yeon‐Soon Ahn
American Journal of Industrial Medicine.2021; 64(4): 245. CrossRef
Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
Seong-Su Moon, Chong Hwa Kim, Seon Mee Kang, Eun Sook Kim, Tae Jung Oh, Jae-Seung Yun, Ho Chan Cho, Dae Jung Kim, Tae Sun Park
Diabetes & Metabolism Journal.2021; 45(1): 115. CrossRef
Risk factors associated with failure of total ankle arthroplasty: a nationwide cohort study
Dong Hun Suh, Kyungdo Han, Jin Woo Lee, Hak Jun Kim, Bongsung Kim, Bong Mo Koo, Hak Kyu Kim, Gi Won Choi
Scientific Reports.2021;[Epub] CrossRef
Impact of body mass index on development of nontuberculous mycobacterial pulmonary disease
Jin Hwa Song, Bong Seong Kim, Nakwon Kwak, Kyungdo Han, Jae-Joon Yim
European Respiratory Journal.2021; 57(2): 2000454. CrossRef
Survival in untreated hepatocellular carcinoma: A national cohort study
Young Ae Kim, Danbee Kang, Hyeyoung Moon, Donghyun Sinn, Minwoong Kang, Sang Myung Woo, Yoon Jung Chang, Boram Park, Sun-Young Kong, Eliseo Guallar, Soo-Yong Shin, Geunyeon Gwak, Joung Hwan Back, Eun Sook Lee, Juhee Cho, Gianfranco D. Alpini
PLOS ONE.2021; 16(2): e0246143. CrossRef
Early and Two-year Outcomes after Sutureless and Conventional Aortic Valve Replacement: a Nationwide Population-based Study
Jae Woong Choi, Ho Jin Kim, Joon Bum Kim, Sak Lee, Cheong Lim, Byung Chul Chang, Youshin Suh, Na Rae Lee, Ho Young Hwang
Journal of Korean Medical Science.2021;[Epub] CrossRef
Assessment of Trends in the Incidence Rates of Central Retinal Artery Occlusion in Korea From 2002 to 2015
Jongshin Kim, Seong Jun Byun, Se Joon Woo, Kyu Hyung Park, Sang Jun Park
JAMA Ophthalmology.2021; 139(4): 399. CrossRef
The incidence of myocardial infarction and stroke in head and neck cancer patients
Hyun-Keun Kwon, Kyung-Do Han, Yong-Il Cheon, Sung-Chan Shin, Minhyung Lee, Eui-Suk Sung, Jin-Choon Lee, Byung-Joo Lee
Scientific Reports.2021;[Epub] CrossRef
Long-term impacts of appendectomy associated with increased incidence of inflammatory bowel disease, infection, and colorectal cancer
Seohee Lee, Eun Jin Jang, Junwoo Jo, So Jung Park, Ho Geol Ryu
International Journal of Colorectal Disease.2021; 36(8): 1643. CrossRef
Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
Scientific Reports.2021;[Epub] CrossRef
Proteinuria Is Associated with the Development of Crohn’s Disease: A Nationwide Population-Based Study
Seona Park, Hyun Jung Lee, Kyung-Do Han, Hosim Soh, Jung Min Moon, Seung Wook Hong, Eun Ae Kang, Jong Pil Im, Joo Sung Kim
Journal of Clinical Medicine.2021; 10(4): 799. CrossRef
Lifestyle is associated with atrial fibrillation development in patients with type 2 diabetes mellitus
Chan Soon Park, Kyung-Do Han, Eue-Keun Choi, Da Hye Kim, Hyun-Jung Lee, So-Ryoung Lee, Seil Oh
Scientific Reports.2021;[Epub] CrossRef
Determining the association between repeatedly elevated serum gamma‐glutamyltransferase levels and risk of respiratory cancer: A nationwide population‐based cohort study
Ye Jin Lee, Kyung‐Do Han, Da Hye Kim, Chang‐Hoon Lee
Cancer Medicine.2021; 10(4): 1366. CrossRef
The Repeatedly Elevated Fatty Liver Index Is Associated With Increased Mortality: A Population-Based Cohort Study
Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak
Frontiers in Endocrinology.2021;[Epub] CrossRef
A nationwide population-based study in South Korea on a relationship between height and anosmia
Jeong Wook Kang, Young Chan Lee, Kyung Do Han, Kun Hee Lee
Scientific Reports.2021;[Epub] CrossRef
Effect of healthcare benefits on short‐term adherence of positive airway pressure therapy
Taehun Lim, Sung Hwan Lim, Beom Mo Koo, Junho Hwang, Joo Hyung Oh, Jihye Rhee, Pona Park
The Clinical Respiratory Journal.2021; 15(7): 735. CrossRef
Comparative Surgical Outcomes of Prosthetic and Native Valve Endocarditis
Won Kyung Pyo, Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Suk Jung Choo, Cheol Hyun Chung, Jae Won Lee
Korean Circulation Journal.2021; 51(6): 504. CrossRef
Analysis of application of dental sedation in attention deficit hyperactivity disorder (ADHD) patients using the Korean National Health Insurance data
Seong In Chi, Hyuk Kim, Kwang-Suk Seo
Journal of Dental Anesthesia and Pain Medicine.2021; 21(2): 99. CrossRef
Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
Chang-Soon Lee, Young Jae Park, Jee Youn Moon, Yong-Chul Kim
Anesthesiology.2021; 134(6): 925. CrossRef
Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
Jong Keun Kim, Young Goo Lee, Kyungdo Han, Jun Hyun Han
Scientific Reports.2021;[Epub] CrossRef
Pre-transplant Dementia is Associated with Poor Survival After Hematopoietic Stem Cell Transplantation: A Nationwide Cohort Study with Propensity Score Matched Control
Sheng-Min Wang, Sung-Soo Park, See Hyun Park, Nak-Young Kim, Dong Woo Kang, Hae-Ran Na, Young-Yi Bae, Jong Wook Lee, Seunghoon Han, Hyun Kook Lim
Clinical Psychopharmacology and Neuroscience.2021; 19(2): 294. CrossRef
Risks and Prognoses of Alzheimer's Disease and Vascular Dementia in Patients With Insomnia: A Nationwide Population-Based Study
Min Seok Baek, Kyungdo Han, Hyuk-Sung Kwon, Yong-ho Lee, Hanna Cho, Chul Hyoung Lyoo
Frontiers in Neurology.2021;[Epub] CrossRef
The Association Between Second-Line Oral Antihyperglycemic Medication on Types of Dementia in Type 2 Diabetes: A Nationwide Real-World Longitudinal Study
Won Jun Kim, Jung Hyun Noh, Kyungdo Han, Cheol-Young Park
Journal of Alzheimer's Disease.2021; 81(3): 1263. CrossRef
Effect of Short-Term Exposure to Fine Particulate Matter and Temperature on Acute Myocardial Infarction in Korea
Jiyoung Shin, Jongmin Oh, In-Sook Kang, Eunhee Ha, Wook-Bum Pyun
International Journal of Environmental Research and Public Health.2021; 18(9): 4822. CrossRef
Incident Parkinson’s disease in kidney transplantation recipients: a nationwide population-based cohort study in Korea
Seon Ha Baek, Sehoon Park, Mi-yeon Yu, Ji Eun Kim, Sang Hyun Park, Kyungdo Han, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Scientific Reports.2021;[Epub] CrossRef
Proteinuria and Psoriasis Risk: A Nationwide Population-Based Study
Eun Hui Bae, Bongseong Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Journal of Clinical Medicine.2021; 10(11): 2356. CrossRef
Risk of COVID-19 and major adverse clinical outcomes among people with disabilities in South Korea
Jae Woo Choi, Euna Han, Sang Gyu Lee, Jaeyong Shin, Tae Hyun Kim
Disability and Health Journal.2021; 14(4): 101127. CrossRef
Use of Proton Pump Inhibitors vs Histamine 2 Receptor Antagonists for the Risk of Gastric Cancer: Population-Based Cohort Study
Ga-Yeong Shin, Jae Myung Park, Jinhyuk Hong, Yu Kyung Cho, Hyeon Woo Yim, Myung-Gyu Choi
American Journal of Gastroenterology.2021; 116(6): 1211. CrossRef
Risk of upper gastrointestinal bleeding in patients on oral anticoagulant and proton pump inhibitor co-therapy
Hyun-Jung Lee, Hyung-Kwan Kim, Bong-Sung Kim, Kyung-Do Han, Jun-Bean Park, Heesun Lee, Seung-Pyo Lee, Yong-Jin Kim, Timir Paul
PLOS ONE.2021; 16(6): e0253310. CrossRef
Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study
Tak Kyu Oh, Eun Sun Jang, In-Ae Song
Scientific Reports.2021;[Epub] CrossRef
Newly diagnosed diabetes has high risk for cardiovascular outcome in ischemic stroke patients
Kyung-Hee Cho, Sun U. Kwon, Ji Sung Lee, Sungwook Yu, A-Hyun Cho
Scientific Reports.2021;[Epub] CrossRef
Tooth loss is associated with an increased risk of hypertension: A nationwide population-based cohort study
Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song, Rajesh Hosadurga
PLOS ONE.2021; 16(6): e0253257. CrossRef
Anemia May Increase the Overall Risk of Cancer: Findings from a Cohort Study with a 12-Year Follow-up Period in South Korea
Tak Kyu Oh, In-Ae Song
Cancer Epidemiology, Biomarkers & Prevention.2021; 30(7): 1440. CrossRef
Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
Hyunsook Choi, Haine Lee, Sang-Soo Lee, Jeonghoon Ahn, Jin Hyun Joh, Moo-Yeol Lee
Annals of Surgical Treatment and Research.2021; 101(1): 20. CrossRef
Seasonal variation of patulous Eustachian tube diagnoses using climatic and national health insurance data
S Lee, S-W Choi, J Kim, H M Lee, S-J Oh, S-K Kong
The Journal of Laryngology & Otology.2021; 135(8): 695. CrossRef
Clinical Study Using Healthcare Claims Database
Jin-Su Park, Chan Hee Lee
Journal of Rheumatic Diseases.2021; 28(3): 119. CrossRef
History of anemia and long-term mortality due to infection: a cohort study with 12 years follow-up in South Korea
Tak Kyu Oh, Kyung-Ho Song, In-Ae Song
BMC Infectious Diseases.2021;[Epub] CrossRef
Trends of age‐related non‐communicable diseases in people living with HIV and comparison with uninfected controls: A nationwide population‐based study in South Korea
Jung Ho Kim, Juhwan Noh, Woojin Kim, Hye Seong, Jun Hyoung Kim, Woon Ji Lee, YaeJee Baek, JongHoon Hyun, Yujin Sohn, Yunsuk Cho, Moo Hyun Kim, SangMin Ahn, Yongseop Lee, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon‐Sup Yeom, Changsoo Kim, Jun Yong Choi
HIV Medicine.2021; 22(9): 824. CrossRef
Risk of Heart Disease after Cholecystectomy: A Nationwide Population-Based Cohort Study in South Korea
Yoo Jin Kim, Young Soo Park, Cheol Min Shin, Kyungdo Han, Sang Hyun Park, Hyuk Yoon, Nayoung Kim, Dong Ho Lee
Journal of Clinical Medicine.2021; 10(15): 3253. CrossRef
Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea
Se Eun Park, Mi Hae Seo, Jung-Hwan Cho, Hyemi Kwon, Yang-Hyun Kim, Kyung-Do Han, Jin-Hyung Jung, Yong-Gyu Park, Eun-Jung Rhee, Won-Young Lee
Diabetes & Metabolism Journal.2021; 45(4): 539. CrossRef
Automatic Classification of Thyroid Findings Using Static and Contextualized Ensemble Natural Language Processing Systems: Development Study
Dongyup Shin, Hye Jin Kam, Min-Seok Jeon, Ha Young Kim
JMIR Medical Informatics.2021; 9(9): e30223. CrossRef
Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours
Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung-Young Oh, Ho Geol Ryu
Journal of Korean Medical Science.2021;[Epub] CrossRef
Prior antiviral treatment and mortality among patients with hepatitis C virus-related hepatocellular carcinoma: A national cohort study
Dong Hyun Sinn, Danbee Kang, Yun Soo Hong, Kwang Cheol Koh, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak, Luca Rinaldi
PLOS ONE.2021; 16(8): e0255624. CrossRef
Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
Yong Suk Jo, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Yuji Kim, Bumhee Yang, Hayoung Choi, Jang Won Sohn, Dong Wook Shin, Hyun Lee
Scientific Reports.2021;[Epub] CrossRef
Effect of aspirin on coronavirus disease 2019
Minkook Son, Myung-giun Noh, Jeong Hoon Lee, Jeongkuk Seo, Hansoo Park, Sung Yang
Medicine.2021; 100(30): e26670. CrossRef
The Association between Peri-Transplant RBC Transfusion and Graft Failure after Kidney Transplantation: A Nationwide Cohort Study
Kyungho Lee, Seohee Lee, Eun Jin Jang, Ga Hee Kim, Seokha Yoo, Minkyoo Lee, Hye Ryoun Jang, Ho Geol Ryu
Journal of Clinical Medicine.2021; 10(16): 3750. CrossRef
Empathy With Patients and Post-Traumatic Stress Response in Verbally Abused Healthcare Workers
Soo-hyun Nam, Dong-Wook Lee, Hwa-yeon Seo, Yun-Chul Hong, Je-Yeon Yun, Sung-jun Cho, Nami Lee
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Smoking cessation, but not reduction, reduces cardiovascular disease incidence
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European Heart Journal.2021; 42(40): 4141. CrossRef
Does Exposure of Lead and Cadmium Affect the Endometriosis?
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International Journal of Environmental Research and Public Health.2021; 18(17): 9077. CrossRef
Association of Periodontal Disease with the Occurrence of Unruptured Cerebral Aneurysm among Adults in Korea: A Nationwide Population-Based Cohort Study
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Being Underweight Increases the Risk of Non-Cystic Fibrosis Bronchiectasis in the Young Population: A Nationwide Population-Based Study
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Nutrients.2021; 13(9): 3206. CrossRef
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Journal of the American Heart Association.2021;[Epub] CrossRef
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BMC Geriatrics.2021;[Epub] CrossRef
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Epidemiology of Achilles Tendon Rupture in South Korea: Claims Data of the National Health Insurance Service from 2009 to 2017
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Clinics in Orthopedic Surgery.2021; 13(4): 539. CrossRef
Comparison of risk profiles for new-onset atrial fibrillation between patients aged <60 and ≥60 years
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Comparison of Risk of Pneumonia Caused by Fluticasone Propionate versus Budesonide in Chronic Obstructive Pulmonary Disease: A Nationwide Retrospective Cohort Study
Jae-Hwa Choi, Keun-Bae Jeong, You Hyun Park, Iseul Yu, Seok Jeong Lee, Myoung Kyu Lee, Sang-Ha Kim, Won-Yeon Lee, Suk Joong Yong, Ji-Ho Lee
International Journal of Chronic Obstructive Pulmonary Disease.2021; Volume 16: 3229. CrossRef
Clinical Impact of Hormone Replacement Therapy on Atrial Fibrillation in Postmenopausal Women: A Nationwide Cohort Study
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Journal of Clinical Medicine.2021; 10(23): 5497. CrossRef
Rheumatoid Arthritis in Silica-Exposed Workers
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International Journal of Environmental Research and Public Health.2021; 18(23): 12776. CrossRef
Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study
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Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study
Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
Journal of Clinical Medicine.2021; 10(24): 5948. CrossRef
Female Reproductive Factors and Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
SSRN Electronic Journal .2021;[Epub] CrossRef
Associations of Systolic Blood Pressure With Incident CKD G3-G5: A Cohort Study of South Korean Adults
Tae Ik Chang, Hyunsun Lim, Cheol Ho Park, Connie M. Rhee, Hamid Moradi, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han
American Journal of Kidney Diseases.2020; 76(2): 224. CrossRef
Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Jee-In Heo, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
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Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study
Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song
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Physical performance and chronic kidney disease development in elderly adults: results from a nationwide cohort study
Young Su Joo, Jong Hyun Jhee, Hyung-Woo Kim, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Jung Tak Park
Aging.2020; 12(17): 17393. CrossRef
Association Between Income Disparities and Risk of Chronic Kidney Disease
Tae Ik Chang, Hyunsun Lim, Cheol Ho Park, Connie M. Rhee, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han
Mayo Clinic Proceedings.2020; 95(2): 231. CrossRef
Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study
Sheng-Min Wang, Sung-Soo Park, Si-Hyun Park, Nak-Young Kim, Dong Woo Kang, Hae-Ran Na, Jong Wook Lee, Seunghoon Han, Hyun Kook Lim
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Label Adherence of Direct Oral Anticoagulants Dosing and Clinical Outcomes in Patients With Atrial Fibrillation
Hee Tae Yu, Pil‐Sung Yang, Eunsun Jang, Tae‐Hoon Kim, Jae‐Sun Uhm, Jong‐Youn Kim, Hui‐Nam Pak, Moon‐Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
Journal of the American Heart Association.2020;[Epub] CrossRef
Associations among Obesity Degree, Glycemic Status, and Risk of Heart Failure in 9,720,220 Korean Adults
Eun-Jung Rhee, Hyemi Kwon, Se Eun Park, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Won-Young Lee
Diabetes & Metabolism Journal.2020; 44(4): 592. CrossRef
Obesity Fact Sheet in Korea, 2019: Prevalence of Obesity and Abdominal Obesity from 2009 to 2018 and Social Factors
Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Eun-Jung Rhee, Seong-Su Lee, Dae Jung Kim, Kwan-Woo Lee, Won-Young Lee
Journal of Obesity & Metabolic Syndrome.2020; 29(2): 124. CrossRef
Safety of acupuncture during pregnancy: a retrospective cohort study in Korea
H‐Y Moon, M‐r Kim, D‐S Hwang, J‐B Jang, J Lee, J‐S Shin, I Ha, YJ Lee
BJOG: An International Journal of Obstetrics & Gynaecology.2020; 127(1): 79. CrossRef
Bell’s palsy and obesity, alcohol consumption and smoking: A nested case-control study using a national health screening cohort
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Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
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Changes in metabolic syndrome and its components and the risk of type 2 diabetes: a nationwide cohort study
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Increased Cardiovascular Risk and All-cause Death in Patients with Behçet Disease: A Korean Nationwide Population-based Dynamic Cohort Study
Hyo-Suk Ahn, Dongjae Lee, Soo Young Lee, Yeong Ho Kim, Ji Hyun Lee, Dong Soo Yu, Kyung-Do Han, Yong Gyu Park, Young Bok Lee
The Journal of Rheumatology.2020; 47(6): 903. CrossRef
Gamma-Glutamyl Transferase Variability and Risk of Dementia in Diabetes Mellitus: A Nationwide Population-Based Study
So-hyeon Hong, Kyungdo Han, Sanghyun Park, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Hye Jin Yoo
The Journal of Clinical Endocrinology & Metabolism.2020; 105(3): e119. CrossRef
Outcomes in relation to antithrombotic therapy among patients with atrial fibrillation after percutaneous coronary intervention
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, Bongseong Kim, You-Jung Choi, So-Ryoung Lee, Jeehoon Kang, Myung-Jin Cha, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chun Chieh Yeh
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Smoking and Alcohol Consumption Are Associated With the Increased Risk of Peritonsillar Abscess
So Young Kim, Hyoseob Lim, Hyo Geun Choi
The Laryngoscope.2020; 130(12): 2833. CrossRef
The Population Prevalence, Associations of Congenital Heart Defect and Mortality Risk for Down’s Syndrome in South Korea Based on National Health Insurance Service (NHIS) Data

Won Kyoung Cho, Na Young Lee, Kyungdo Han, Byung-Kyu Suh, Yong-Gyu Park
Clinical Epidemiology.2020; Volume 12: 519. CrossRef
Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes: a nationwide population-based study
Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
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Jung Min Moon, Eun Ae Kang, Kyungdo Han, Seung Wook Hong, Hosim Soh, Seona Park, Jooyoung Lee, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
World Journal of Gastroenterology.2020; 26(4): 404. CrossRef
Improved oral hygiene is associated with decreased risk of new-onset diabetes: a nationwide population-based cohort study
Yoonkyung Chang, Ji Sung Lee, Ki-Jung Lee, Ho Geol Woo, Tae-Jin Song
Diabetologia.2020; 63(5): 924. CrossRef
Development of stroke identification algorithm for claims data using the multicenter stroke registry database
Jun Yup Kim, Keon-Joo Lee, Jihoon Kang, Beom Joon Kim, Moon-Ku Han, Seong-Eun Kim, Heeyoung Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Moo-Seok Park, Sang-Soon Park, Kyung Bok Lee, Hong-Kyun Park,
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Cardiovascular Research Using the Korean National Health Information Database
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Korean Circulation Journal.2020; 50(9): 754. CrossRef
Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
Gastrointestinal Endoscopy.2020; 92(3): 613. CrossRef
Bodyweight fluctuation is associated with increased risk of incident atrial fibrillation
Hyun-Jung Lee, Eue-Keun Choi, Kyung-Do Han, Euijae Lee, Inki Moon, So-Ryoung Lee, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip
Heart Rhythm.2020; 17(3): 365. CrossRef
Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
Heng Piao, Jae Moon Yun, Aesun Shin, Belong Cho
Biomolecules & Therapeutics.2020; 28(1): 110. CrossRef
Early detection of influenza outbreak using time derivative of incidence
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EPJ Data Science.2020;[Epub] CrossRef
A prediction model of low back pain risk: a population based cohort study in Korea
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The Korean Journal of Pain.2020; 33(2): 153. CrossRef
The impact of PM2.5 on acute otitis media in children (aged 0–3): A time series study
Jongmin Oh, Seulbi Lee, Min-ho Kim, Youngrin Kwag, Hae Soon Kim, Soontae Kim, Shinhee Ye, Eunhee Ha
Environment International.2020; 145: 106133. CrossRef
Serum gamma-glutamyltransferase activity and Parkinson’s disease risk in men and women
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Scientific Reports.2020;[Epub] CrossRef
Association between institutional case volume and mortality following thoracic aorta replacement: a nationwide Korean cohort study
Karam Nam, Eun Jin Jang, Jun Woo Jo, Jae Woong Choi, Minkyoo Lee, Ho Geol Ryu
Journal of Cardiothoracic Surgery.2020;[Epub] CrossRef
Underutilization of Hospital-based Cardiac Rehabilitation after Acute Myocardial Infarction in Korea
Sun-Hyung Kim, Jun-soo Ro, Yoon Kim, Ja-Ho Leigh, Won-Seok Kim
Journal of Korean Medical Science.2020;[Epub] CrossRef
Infection, antibiotic exposure and development of atopic dermatitis: A nationwide case–control study
Chong Won Choi, Bo Ram Yang, Dong In Suh, Mi‐Sook Kim, Jungyoon Ohn, Jong Soo Hong, Joongyub Lee, Kyu Han Kim
The Journal of Dermatology.2020; 47(7): 707. CrossRef
Effect of the variability of blood pressure, glucose level, total cholesterol level, and body mass index on the risk of atrial fibrillation in a healthy population
So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Seung-Hwan Lee, Seil Oh
Heart Rhythm.2020; 17(1): 12. CrossRef
Impact of Mitral Valve Repair Case Volume on Postoperative Mortality　― A Nationwide Korean Cohort Study ―
Karam Nam, Eun Jin Jang, Jun Woo Jo, Jae Woong Choi, Jun Gi Jo, Jaehun Lee, Ho Geol Ryu
Circulation Journal.2020; 84(9): 1493. CrossRef
The Clinical Impact of Body Mass Index on Breast Cancer in Korea: A Nationwide Population-Based Cohort Study
Jae Hwan Jeong, Hak Min Lee, Hai Young Son, Ilkyun Lee
Journal of Breast Disease.2020; 8(1): 51. CrossRef
Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide population-based cohort study
Yoonkyung Chang, Ho Geol Woo, Jin Park, Ji Sung Lee, Tae-Jin Song
European Journal of Preventive Cardiology.2020; 27(17): 1835. CrossRef
Increased Mortality Burden in Young Asian Subjects with Dysglycemia and Comorbidities
Eun-Jung Rhee, Inha Jung, Hyemi Kwon, Se Eun Park, Yang-Hyun Kim, Kyung-Do Han, Yong-Gyu Park, Won-Young Lee
Journal of Clinical Medicine.2020; 9(4): 1042. CrossRef
Fasting Plasma Glucose Variability and Gastric Cancer Risk in Individuals Without Diabetes Mellitus: A Nationwide Population-Based Cohort Study
So-hyeon Hong, Eunjin Noh, Jinsil Kim, Soon Young Hwang, Jun A. Kim, You-Bin Lee, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
Clinical and Translational Gastroenterology.2020; 11(9): e00221. CrossRef
Use of Gadoxetic Acid–enhanced Liver MRI and Mortality in More than 30 000 Patients with Hepatocellular Carcinoma: A Nationwide Analysis
Tae Wook Kang, Sun-Young Kong, Danbee Kang, Min Woong Kang, Young Kon Kim, Seong Hyun Kim, Dong Hyun Sinn, Young Ae Kim, Kui Son Choi, Eun Sook Lee, Sang Myung Woo, Joung Hwan Back, Eliseo Guallar, Juhee Cho
Radiology.2020; 295(1): 114. CrossRef
The association between sialolithiasis and smoking, alcohol drinking and obesity in Korea: a nested case-control study
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BMC Public Health.2020;[Epub] CrossRef
Outcomes for Inappropriate Renal Dose Adjustment of Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus: Population-Based Study
Sangmo Hong, Kyungdo Han, Cheol-Young Park
Mayo Clinic Proceedings.2020; 95(1): 101. CrossRef
Impact of Mean and Variability of High‐Density Lipoprotein‐Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population
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Journal of the American Heart Association.2020;[Epub] CrossRef
Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009–2017
Yang-Hyun Kim, Jun Goo Kang, Seong Jin Lee, Kyung-do Han, Sung-Hee Ihm, Kyung-Hwan Cho, Yong-Gyu Park
Diabetes Care.2020; 43(5): 1118. CrossRef
Pneumonia risk and its associated factors in Parkinson's disease: A National Database Study
Jun Hee Won, Seong Jun Byun, Byung-Mo Oh, Han-Joon Kim, Sang Jun Park, Han Gil Seo
Journal of the Neurological Sciences.2020; 415: 116949. CrossRef
The Association with rhegmatogenous retinal detachment and paediatric atopic dermatitis: a 12-year Nationwide Cohort Study
M. Choi, S. J. Byun, D. H. Lee, K. H. Kim, K. H. Park, S. J. Park
Eye.2020; 34(10): 1909. CrossRef
Peripartum Blood Transfusions are Associated with Increased Risk of Cancer: A National Retrospective Cohort Study

Geum Joon Cho, Michael S Oh, Min-Jeong Oh, Keon Vin Park, Sung Won Han, Young Kwang Chae
Clinical Epidemiology.2020; Volume 12: 659. CrossRef
The Burden of Cervical Cancer in Korea: A Population-Based Study
Jinhee Kim, Donghwan Lee, Kyung-Bok Son, SeungJin Bae
International Journal of Environmental Research and Public Health.2020; 17(17): 6308. CrossRef
Temporal trends of catheter ablation for patients with atrial fibrillation: A Korean nationwide population‐based study
Euijae Lee, So‐Ryoung Lee, Eue‐Keun Choi, Kyung‐Do Han, Myung‐Jin Cha, Gregory Y.H. Lip, Seil Oh
Journal of Cardiovascular Electrophysiology.2020; 31(10): 2616. CrossRef
Trend of prevalence and incidence of systemic lupus erythematosus in South Korea, 2005 to 2015: a nationwide population-based study
Eun Hui Bae, Sang Yeob Lim, Kyung-Do Han, Jin-Hyung Jung, Hong Sang Choi, Ha Yeon Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
The Korean Journal of Internal Medicine.2020; 35(3): 652. CrossRef
Achievement of the low-density lipoprotein cholesterol goal among patients with dyslipidemia in South Korea
Siin Kim, Sola Han, Pratik P. Rane, Yi Qian, Zhongyun Zhao, Hae Sun Suh, Luigina Guasti
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Oral health and gastrointestinal cancer: A nationwide cohort study
Kijeong Lee, Ji Sung Lee, Jinkwon Kim, Huisong Lee, Yoonkyung Chang, Ho Geol Woo, Jin‐Woo Kim, Tae‐Jin Song
Journal of Clinical Periodontology.2020; 47(7): 796. CrossRef
Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
The Korean Journal of Internal Medicine.2020; 35(3): 641. CrossRef
Data Configuration and Publication Trends for the Korean National Health Insurance and Health Insurance Review & Assessment Database
Hae Kyung Kim, Sun Ok Song, Junghyun Noh, In-Kyung Jeong, Byung-Wan Lee
Diabetes & Metabolism Journal.2020; 44(5): 671. CrossRef
Metformin and Gastrointestinal Cancer Development in Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea
Ji Hong You, Sun Ok Song, Min Jin Kang, Yoon Young Cho, Sun Wook Kim, Sung Hwan Suh, Sujin Lee, Yong-ho Lee, Byung-Wan Lee
Clinical and Translational Gastroenterology.2020; 11(11): e00254. CrossRef
Machine learning prediction for mortality of patients diagnosed with COVID-19: a nationwide Korean cohort study
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The association between hospital case volume and in-hospital and one-year mortality after hip fracture surgery
Seokha Yoo, Eun Jin Jang, Junwoo Jo, Jun Gi Jo, Seungpyo Nam, Hansol Kim, Hannah Lee, Ho Geol Ryu
The Bone & Joint Journal.2020; 102-B(10): 1384. CrossRef
Association between physical activity and conversion from mild cognitive impairment to dementia
Yeo Jin Kim, Kyung-Do Han, Min Seok Baek, Hanna Cho, Eun Joo Lee, Chul Hyoung Lyoo
Alzheimer's Research & Therapy.2020;[Epub] CrossRef
Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko
Endocrinology and Metabolism.2020; 35(4): 901. CrossRef
Does Diabetes Increase the Risk of Contracting COVID-19? A Population-Based Study in Korea
Sung-Youn Chun, Dong Wook Kim, Sang Ah Lee, Su Jung Lee, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim, Sun Ok Song
Diabetes & Metabolism Journal.2020; 44(6): 897. CrossRef
The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study
Sangmo Hong, Kyungdo Han, Cheol-Young Park
BMC Medicine.2020;[Epub] CrossRef
The durability and effectiveness of sensor-augmented insulin pump therapy in pediatric and young adult patients with type 1 diabetes
Yun Jeong Lee, Young Ah Lee, Jae Hyun Kim, Hye Rim Chung, Min Jeong Gu, Ji Young Kim, Choong Ho Shin
Annals of Pediatric Endocrinology & Metabolism.2020; 25(4): 248. CrossRef
Impact of comorbid asthma on severity of coronavirus disease (COVID-19)
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Scientific Reports.2020;[Epub] CrossRef
Big Data in Ophthalmology
Ching-Yu Cheng, Zhi Da Soh, Shivani Majithia, Sahil Thakur, Tyler Hyungtaek Rim, Yih Chung Tham, Tien Yin Wong
Asia-Pacific Journal of Ophthalmology.2020; 9(4): 291. CrossRef
Maintenance of body weight is an important determinant for the risk of ischemic stroke: A nationwide population-based cohort study
Jung-Hwan Cho, Eun-Jung Rhee, Se Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Soon-Jib Yoo, Yang-Hyun Kim, Won-Young Lee, Sabine Rohrmann
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Effect of Institutional Case Volume on In-Hospital and Long-Term Mortality in Critically Ill Patients Requiring Mechanical Ventilation for 48 Hours or More
Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung Young Oh, Ho Geol Ryu
Journal of Korean Medical Science.2019;[Epub] CrossRef
Impact of the 2015 Middle East Respiratory Syndrome Outbreak on Emergency Care Utilization and Mortality in South Korea
Sun Young Lee, Young-Ho Khang, Hwa-Kyung Lim
Yonsei Medical Journal.2019; 60(8): 796. CrossRef
Effect of Institutional Case Volume on In-hospital Mortality After Living Donor Liver Transplantation: Analysis of 7073 Cases Between 2007 and 2016 in Korea
Seokha Yoo, Eun Jin Jang, Nam-Joon Yi, Ga Hee Kim, Dal Ho Kim, Hannah Lee, Chul-Woo Jung, Ho Geol Ryu
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Increased risk of benign paroxysmal positional vertigo in osteoporosis: a nationwide population-based cohort study
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Incremental economic burden associated with exudative age-related macular degeneration: a population-based study
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Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study
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Journal of Clinical Medicine.2019; 8(8): 1191. CrossRef
Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population
Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Hyejung Shin, Ha Yan Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
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Perioperative red blood cell transfusion and mortality following heart transplantation: A retrospective nationwide population‐based study between 2007 and 2016 in Korea
Karam Nam, Eun Jin Jang, Ga Hee Kim, Hyung Been Yhim, Hannah Lee, Dal Ho Kim, Ho Geol Ryu
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The Effect of Health-Related Behaviors on Disease Progression and Mortality in Early Stages of Chronic Kidney Disease: A Korean Nationwide Population-Based Study
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World Journal of Urology.2019; 37(11): 2393. CrossRef
Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study
Min Jung Ko, Ae Jeong Jo, Yun Jung Kim, Shin Hee Kang, Songhee Cho, Sang‐Ho Jo, Cheol‐Young Park, Sung‐Cheol Yun, Woo Je Lee, Duk‐Woo Park
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J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko
Diabetes & Metabolism.2019; 45(1): 19. CrossRef
Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study
Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-ho Lee
The Journal of Clinical Endocrinology & Metabolism.2019; 104(7): 2942. CrossRef
Increased Risk of Osteoporotic Fracture in Postgastrectomy Gastric Cancer Survivors Compared With Matched Controls: A Nationwide Cohort Study in Korea
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Yun-Suhk Suh, Yoon Jin Choi, Su-Min Jeong, Jae Moon Yun, Sun Ok Song, Youngmin Park
American Journal of Gastroenterology.2019; 114(11): 1735. CrossRef
Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study
Ha-Na Kim, Kyungdo Han, Yong-Gyu Park, Ji Hyun Lee
Metabolism.2019; 99: 19. CrossRef
Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea
Jae-Young Hong, Kyungdo Han, Jin-Hyung Jung, Jung Sun Kim
JAMA Network Open.2019; 2(9): e1910584. CrossRef
Long‐term clinical outcomes in patients with autoimmune hepatitis according to treatment response in Asian country
Jonggi Choi, Gwang Hyeon Choi, Danbi Lee, Ju Hyun Shim, Young‐Suk Lim, Han Chu Lee, Young‐Hwa Chung, Yung‐Sang Lee, Kang Mo Kim
Liver International.2019; 39(5): 985. CrossRef
Effectiveness and Safety of Direct Oral Anticoagulant for Secondary Prevention in Asians with Atrial Fibrillation
Jiesuck Park, So-Ryoung Lee, Eue-Keun Choi, Soonil Kwon, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Sang-Bae Ko, Seil Oh, Gregory Y. H. Lip
Journal of Clinical Medicine.2019; 8(12): 2228. CrossRef
Optimal Rivaroxaban Dose in Asian Patients With Atrial Fibrillation and Normal or Mildly Impaired Renal Function
So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Jin-Hyung Jung, Seil Oh, Gregory Y.H. Lip
Stroke.2019; 50(5): 1140. CrossRef
Tobacco Smoking and Alcohol Consumption Are Related to Benign Parotid Tumor: A Nested Case-Control Study Using a National Health Screening Cohort
So Young Kim, Chanyang Min, Dong Jun Oh, Hyo Geun Choi
Clinical and Experimental Otorhinolaryngology.2019; 12(4): 412. CrossRef
Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Study in Korea
Eun Ae Kang, Kyungdo Han, Jaeyoung Chun, Hosim Soh, Seona Park, Jong Pil Im, Joo Sung Kim
Journal of Clinical Medicine.2019; 8(3): 343. CrossRef
Changes in the Diagnostic Efficiency of Thyroid Fine-Needle Aspiration Biopsy during the Era of Increased Thyroid Cancer Screening in Korea
Young Ki Lee, Kyeong Hye Park, Young Duk Song, Taemi Youk, Joo Young Nam, Sun Ok Song, Dong Yeob Shin, Eun Jig Lee
Cancer Research and Treatment.2019; 51(4): 1430. CrossRef
Safety and Effectiveness of Contemporary P2Y 12 Inhibitors in an East Asian Population With Acute Coronary Syndrome: A Nationwide Population‐Based Cohort Study
Ji Eun Yun, Yun Jung Kim, Ji Jeong Park, Sehee Kim, Keunhui Park, Min Soo Cho, Gi‐Byoung Nam, Duk‐Woo Park
Journal of the American Heart Association.2019;[Epub] CrossRef
Direct Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Low Body Weight
So-Ryoung Lee, Eue-Keun Choi, Chan Soon Park, Kyung-Do Han, Jin-Hyung Jung, Seil Oh, Gregory Y.H. Lip
Journal of the American College of Cardiology.2019; 73(8): 919. CrossRef
Trends in varicella and herpes zoster epidemiology before and after the implementation of universal one-dose varicella vaccination over one decade in South Korea, 2003–2015
Jae-Ki Choi, Sun Hee Park, Sanghyun Park, Su-Mi Choi, Si-Hyun Kim, Dong-Gun Lee, Jin-Hong Yoo, Jung-Hyun Choi, Jin Han Kang
Human Vaccines & Immunotherapeutics.2019; 15(11): 2554. CrossRef
Obesity Fact Sheet in Korea, 2018: Data Focusing on Waist Circumference and Obesity-Related Comorbidities
Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong Gyu Park, Kwan-Woo Lee, Eun-Jung Rhee, Jang Won Son, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo
Journal of Obesity & Metabolic Syndrome.2019; 28(4): 236. CrossRef
Long-Term Impact of Newly Diagnosed Atrial Fibrillation During Critical Care
Kyu Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
Chest.2019; 156(3): 518. CrossRef
Correlation of Androgen Deprivation Therapy with Cognitive Dysfunction in Patients with Prostate Cancer: A Nationwide Population-Based Study Using the National Health Insurance Service Database
Bum Sik Tae, Byung Jo Jeon, Seung Hun Shin, Hoon Choi, Jae Hyun Bae, Jae Young Park
Cancer Research and Treatment.2019; 51(2): 593. CrossRef
Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation and Valvular Heart Disease
Inki Moon, So-Ryoung Lee, Eue-Keun Choi, Euijae Lee, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip
Journal of Clinical Medicine.2019; 8(10): 1624. CrossRef
Relation between Baseline Height and New Diabetes Development: A Nationwide Population-Based Study
Eun-Jung Rhee, Jung-Hwan Cho, Hyemi Kwon, Se-Eun Park, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Yang-Hyun Kim, Won-Young Lee
Diabetes & Metabolism Journal.2019; 43(6): 794. CrossRef
The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study
Jung-Hwan Cho, Eun-Jung Rhee, Se-Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Hye Soon Park, Yang-Hyun Kim, Soon-Jib Yoo, Won-Young Lee
Diabetes & Metabolism Journal.2019; 43(2): 206. CrossRef
The risk of end-stage renal disease in systemic lupus erythematosus
Hong Sang Choi, Kyung-Do Han, Jin-Hyung Jung, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Medicine.2019; 98(28): e16420. CrossRef
Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention During 2-Year Follow-Up, from a Nationwide Population Study
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-Jung Choi, So-Ryoung Lee, Myung-Jin Cha, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y.H. Lip
The American Journal of Cardiology.2019; 123(12): 1921. CrossRef
Outcomes After Use of Standard- and Low-Dose Non–Vitamin K Oral Anticoagulants in Asian Patients With Atrial Fibrillation
Min Soo Cho, Ji Eun Yun, Ji Jeong Park, Yun Jung Kim, Jessie Lee, Hyungmin Kim, Duk-Woo Park, Gi-Byoung Nam
Stroke.2019; 50(1): 110. CrossRef
Association between Atrial Fibrillation, Myocardial Infarction, Heart Failure and Mortality in Patients with Nontuberculous Mycobacterial Infection: a nationwide population-based study
Chan Soon Park, Eue-Keun Choi, Bongseong Kim, Kyung-Do Han, So-Ryoung Lee, Myung-Jin Cha, Seil Oh
Scientific Reports.2019;[Epub] CrossRef
National practice patterns and direct medical costs for prostate cancer in Korea across a 10 year period: a nationwide population-based study using a national health insurance database
Ho Won Kang, Seok-Joong Yun, Jae Il Chung, Hoon Choi, Jae Heon Kim, Ho Song Yu, Yun-Sok Ha, In-Chang Cho, Hyung Joon Kim, Hyun Chul Chung, Jun Sung Koh, Wun-Jae Kim, Jong-Hyock Park, Ji Youl Lee, So-Young Kim
BMC Health Services Research.2019;[Epub] CrossRef
Institutional Case-Volume and Mortality After Heart Transplantation
Karam Nam, Eun Jin Jang, Ga Hee Kim, Hannah Lee, Dal Ho Kim, Ho Geol Ryu
International Heart Journal.2019; 60(3): 695. CrossRef
Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
Scientific Reports.2019;[Epub] CrossRef
Venous thromboembolism in relapsed or refractory multiple myeloma patients treated with lenalidomide plus dexamethasone
Junghoon Shin, Je-Jung Lee, Kihyun Kim, Chang-Ki Min, Jeong-Ok Lee, Cheolwon Suh, Jin Seok Kim, Yoo Jin Lee, Sung-Soo Yoon, Jae-Cheol Jo, Ho Sup Lee, Soo-Mee Bang
International Journal of Hematology.2019; 109(1): 79. CrossRef
Actinic keratosis and diabetes complications: A nationwide population-based study in South Korea (2009–2015)
YoungBok Lee, JiHyun Lee, JinYoung Choi, DongSoo Yu, KyungDo Han, Yong-Gyu Park
Diabetes & Metabolism.2019; 45(1): 32. CrossRef
Ankylosing spondylitis: A novel risk factor for atrial fibrillation — A nationwide population-based study
Inki Moon, Eue-Keun Choi, Jin-Hyung Jung, Kyung-Do Han, You-Jung Choi, Jiesuck Park, Jun Hwan Cho, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh
International Journal of Cardiology.2019; 275: 77. CrossRef
Cancer risk among young men with weight gain after smoking cessation: A population-based cohort study
Kyuwoong Kim, Seulggie Choi, Gyeongsil Lee, Su-Min Jeong, Sung Min Kim, Joung Sik Son, Jae-Moon Yun, Yeon-Yong Kim, Seong Yong Park, Sang Min Park
Cancer Epidemiology.2019; 60: 86. CrossRef
Effect of drug compliance on health care costs in newly-diagnosed dementia: Analysis of nationwide population-based data
Seung-Taek Oh, Kyu-Tae Han, Won-Jung Choi, Jaesub Park
Journal of Psychiatric Research.2019; 118: 31. CrossRef
Colorectal Cancer Risks According to Sex Differences in Patients With Type II Diabetes Mellitus: A Korean Nationwide Population-Based Cohort Study
Ji Min Lee, Kang-Moon Lee, Dae Bum Kim, Seung-Hyun Ko, Yong Gyu Park
Clinical and Translational Gastroenterology.2019; 10(10): e00090. CrossRef
Body Mass Index Variability and Long-term Risk of New-Onset Atrial Fibrillation in the General Population: A Korean Nationwide Cohort Study
Yeong-Min Lim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip
Mayo Clinic Proceedings.2019; 94(2): 225. CrossRef
Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study
Hak Min Lee, Bo Wook Kim, Seho Park, Sungmin Park, Jeon Eon Lee, Young Jin Choi, Sung Yong Kim, Sang Uk Woo, Hyun Jo Youn, Ilkyun Lee
Breast Cancer Research and Treatment.2019; 176(2): 419. CrossRef
Obstructive sleep apnea as a risk factor for incident end stage renal disease: a nationwide population-based cohort study from Korea
Hong Sang Choi, Ha Yeon Kim, Kyung-Do Han, Jin-Hyung Jung, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Clinical and Experimental Nephrology.2019; 23(12): 1391. CrossRef
Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
Cardiovascular Diabetology.2019;[Epub] CrossRef
Severity of dental caries and risk of coronary heart disease in middle-aged men and women: a population-based cohort study of Korean adults, 2002–2013
Kyuwoong Kim, Seulggie Choi, Jooyoung Chang, Sung Min Kim, Seon Jip Kim, Ryan Jin-Young Kim, Hyun-Jae Cho, Sang Min Park
Scientific Reports.2019;[Epub] CrossRef
Risk of Anxiety and Depression in Patients with Inflammatory Bowel Disease: A Nationwide, Population-Based Study
Kookhwan Choi, Jaeyoung Chun, Kyungdo Han, Seona Park, Hosim Soh, Jihye Kim, Jooyoung Lee, Hyun Lee, Jong Im, Joo Kim
Journal of Clinical Medicine.2019; 8(5): 654. CrossRef
The Effects after Implementing a Drug Utilization Review System on Contraindicated Drug use: A Systematic Review
Heeyoung Lee, Hyea Suk Choi, Eunhee Ji
Korean Journal of Clinical Pharmacy.2019; 29(1): 9. CrossRef
Nationwide Trends in Pancreatitis and Pancreatic Cancer Risk Among Patients With Newly Diagnosed Type 2 Diabetes Receiving Dipeptidyl Peptidase 4 Inhibitors
Minyoung Lee, Jiyu Sun, Minkyung Han, Yongin Cho, Ji-Yeon Lee, Chung Mo Nam, Eun Seok Kang
Diabetes Care.2019; 42(11): 2057. CrossRef
Dose–response relationship between cigarette smoking and risk of ulcerative colitis: a nationwide population-based study
Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
Journal of Gastroenterology.2019; 54(10): 881. CrossRef
Is androgen deprivation therapy associated with cerebral infarction in patients with prostate cancer? A Korean nationwide population‐based propensity score matching study
Bum Sik Tae, Byeong Jo Jeon, Hoon Choi, Jae Hyun Bae, Jae Young Park
Cancer Medicine.2019; 8(9): 4475. CrossRef
Adult lung transplantation case-volume and in-hospital and long-term mortality in Korea
Susie Yoon, Eun Jin Jang, Ga Hee Kim, Dal Ho Kim, Tae-Yoon Lim, Hannah Lee, Ho Geol Ryu
Journal of Cardiothoracic Surgery.2019;[Epub] CrossRef
Systemic lupus erythematosus is a risk factor for cancer: a nationwide population-based study in Korea
E.H. Bae, S.Y. Lim, K.-D. Han, J.-Hy. Jung, H.S. Choi, C.S. Kim, S.K. Ma, SW Kim
Lupus.2019; 28(3): 317. CrossRef
Association Between Drug Exposure and Occurrence of Parkinsonism in Korea: A Population-Based Case-Control Study
Siin Kim, Sang-Myung Cheon, Hae Sun Suh
Annals of Pharmacotherapy.2019; 53(11): 1102. CrossRef
Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
Jiesuck Park, Soonil Kwon, Eue-Keun Choi, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh
International Journal of Arrhythmia.2019;[Epub] CrossRef
HDL-Cholesterol, Its Variability, and the Risk of Diabetes: A Nationwide Population-Based Study
Seung-Hwan Lee, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Kyungdo Han, Mee Kyoung Kim
The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5633. CrossRef
Prognostic influence of Korean public medical insurance system on breast cancer patients
Ki-Tae Hwang, Young Wook Ju, Young A Kim, Jongjin Kim, Sohee Oh, Jiwoong Jung, Young Jun Chai, In Sil Choi, So Won Oh
Annals of Surgical Treatment and Research.2019; 96(2): 58. CrossRef
Effect of Case Volume on Mortality After Pediatric Liver Transplantation in Korea
Hannah Lee, Eun Jin Jang, Ga Hee Kim, Nam Joon Yi, Dal Ho Kim, Seokha Yoo, Hyung Sang Row, Chul-Woo Jung, Seung-Young Oh, Ho Geol Ryu
Transplantation.2019; 103(8): 1649. CrossRef
Prescription Patterns and Burden of Pediatric Asthma in Korea
In Suk Sol, Yoon Hee Kim, Soo Yeon Kim, Sun Ha Choi, Jong Deok Kim, Bo Ok Kim, Ji Eun Moon, Kyung Won Kim, Myung Hyun Sohn
Allergy, Asthma & Immunology Research.2019; 11(2): 280. CrossRef
Increased risk of coronary heart disease and stroke in lung cancer survivors: A Korean nationwide study of 20,458 patients
Dong Woog Yoon, Dong Wook Shin, Jong Ho Cho, Jeong Hoon Yang, Su-Min Jeong, Kyungdo Han, Sang Hyun Park
Lung Cancer.2019; 136: 115. CrossRef
Waist Circumference and All-Cause Mortality Independent of Body Mass Index in Korean Population from the National Health Insurance Health Checkup 2009–2015
Yang-Hyun Kim, Seon Mee Kim, Kyung-Do Han, Jin-Hyung Jung, Seong-Su Lee, Sang Woo Oh, Hye Soon Park, Eun-Jung Rhee, Won-Young Lee, Soon Jib Yoo
Journal of Clinical Medicine.2019; 8(1): 72. CrossRef
Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri
PLOS ONE.2019; 14(1): e0209593. CrossRef
Factors influencing the incidence and treatment of intracranial aneurysm and subarachnoid hemorrhage: time trends and socioeconomic disparities under an universal healthcare system
Won Kyung Lee, Chang Wan Oh, Heeyoung Lee, Kun Sei Lee, Hyeonseon Park
Journal of NeuroInterventional Surgery.2019; 11(2): 159. CrossRef
Increasing trends in hospital care burden of atrial fibrillation in Korea, 2006 through 2015
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
Heart.2018; 104(24): 2010. CrossRef
Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk
DA YOUNG LEE, EUN-JUNG RHEE, JUNG HWAN CHO, HYEMI KWON, SE EUN PARK, YANG-HYUN KIM, KYUNGDO HAN, YONG-KYU PARK, SOON JIB YOO, WON-YOUNG LEE
Medicine & Science in Sports & Exercise.2018; 50(12): 2451. CrossRef
The effect of continuity of care on the incidence of end-stage renal disease in patients with newly detected type 2 diabetic nephropathy: a retrospective cohort study
Yun Jung Jang, Yoon Soo Choy, Chung Mo Nam, Ki Tae Moon, Eun-Cheol Park
BMC Nephrology.2018;[Epub] CrossRef
Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study
Seona Park, Jaeyoung Chun, Kyung-Do Han, Hosim Soh, Kookhwan Choi, Ji Hye Kim, Jooyoung Lee, Changhyun Lee, Jong Pil Im, Joo Sung Kim
World Journal of Gastroenterology.2018; 24(42): 4798. CrossRef
Cardiovascular disease risk differences between bus company employees and general workers according to the Korean National Health Insurance Data
Ji-Hoo Yook, Dong-Wook Lee, Min-Seok Kim, Yun-Chul Hong
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
Impact of Renal Function on Outcomes With Edoxaban in Real-World Patients With Atrial Fibrillation
Hee Tae Yu, Pil-Sung Yang, Tae-Hoon Kim, Eunsun Jang, Daehoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
Stroke.2018; 49(10): 2421. CrossRef
Association between adult height, myocardial infarction, heart failure, stroke and death: a Korean nationwide population-based study
Chan Soon Park, Eue-Keun Choi, Kyung-Do Han, Hyun Jung Lee, Tae-Min Rhee, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Si-Hyuck Kang, Seil Oh
International Journal of Epidemiology.2018; 47(1): 289. CrossRef
Dietary Fat Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies
Minkyeong Kim, Kyong Park
Nutrients.2018; 10(12): 1963. CrossRef
Association Between Changes in Hemoglobin Concentration and Cardiovascular Risks and All‐Cause Mortality Among Young Women
Gyeongsil Lee, Seulggie Choi, Kyuwoong Kim, Jae‐Moon Yun, Joung Sik Son, Su‐Min Jeong, Sung Min Kim, Yeon‐Yong Kim, Seong Yong Park, Youngil Koh, Seung‐sik Hwang, Sang Min Park
Journal of the American Heart Association.2018;[Epub] CrossRef
The economic burden of rotavirus infection in South Korea from 2009 to 2012
Kyung Suk Lee, Ye-Rin Lee, So-Youn Park, In-Hwan Oh, Donald R. Olson
PLOS ONE.2018; 13(3): e0194120. CrossRef
Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)
Young Bok Lee, Ji Hyun Lee, Soo Young Lee, Jin‐Wou Kim, Dong Soo Yu, Kyung Do Han, Yong Gyu Park
The Journal of Dermatology.2018; 45(12): 1396. CrossRef
Protective Effect of Metformin Against Thyroid Cancer Development: A Population-Based Study in Korea
Yoon Young Cho, Min Jin Kang, Soo Kyoung Kim, Jung Hwa Jung, Jong Ryeal Hahm, Tae Hyuk Kim, Joo Young Nam, Byung-Wan Lee, Yong-ho Lee, Jae Hoon Chung, Sun Ok Song, Sun Wook Kim
Thyroid.2018; 28(7): 864. CrossRef
Association of oral ciprofloxacin, levofloxacin, ofloxacin and moxifloxacin with the risk of serious ventricular arrhythmia: a nationwide cohort study in Korea
Yongil Cho, Hyun Soo Park
BMJ Open.2018; 8(9): e020974. CrossRef
The risk of alopecia areata and other related autoimmune diseases in patients with sleep disorders: a Korean population–based retrospective cohort study
Hyun-Min Seo, Tae Lim Kim, Joung Soo Kim
Sleep.2018;[Epub] CrossRef
Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining
Chul Hwan Bang, Jae Woong Yoon, Hyun Ji Lee, Jun Young Lee, Young Min Park, Suk Jun Lee, Ji Hyun Lee
Scientific Reports.2018;[Epub] CrossRef
Age Threshold for Ischemic Stroke Risk in Atrial Fibrillation
Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip
Stroke.2018; 49(8): 1872. CrossRef
Variations of Prevalence and Incidence of Atrial Fibrillation and Oral Anticoagulation Rate According to Different Analysis Approaches
Pil-Sung Yang, Soorack Ryu, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jinseub Hwang, Boyoung Joung, Gregory Y. H. Lip
Scientific Reports.2018;[Epub] CrossRef
Reciprocal relationship between herpes zoster and cardiovascular diseases: A nationwide population‐based case–control study in Korea
Hyun‐Min Seo, Myung‐Jin Cha, Ju Hee Han, Kyungdo Han, Sang Hyun Park, Chul Hwan Bang, Ji Hyun Lee, Jun Young Lee, Eue‐Keun Choi, Young Min Park
The Journal of Dermatology.2018; 45(11): 1312. CrossRef
Hypertension and risk of psoriasis incidence: An 11-year nationwide population-based cohort study
Ha-Na Kim, Kyungdo Han, Sang-Wook Song, Ji Hyun Lee, Valerio De Vita
PLOS ONE.2018; 13(8): e0202854. CrossRef
Association between abdominal obesity and increased risk for the development of hypertension regardless of physical activity: A nationwide population‐based study
Eun‐Jung Rhee, Jung‐Hwan Cho, Hyemi Kwon, Se‐Eun Park, Jin‐Hyung Jung, Kyung‐Do Han, Yong‐Gyu Park, Hye Soon Park, Yang‐Hyun Kim, Soon‐Jib Yoo, Won‐Young Lee
The Journal of Clinical Hypertension.2018; 20(10): 1417. CrossRef
Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients
Bo Ram Yang, Nam-Kyong Choi, Mi-Sook Kim, Jaeyoung Chun, Sang Hyun Joo, Hyesung Kim, Joongyub Lee, Gang Liu
PLOS ONE.2018; 13(7): e0200363. CrossRef
Need for Systematic Efforts to Modify Health-Related Behaviors After Acute Myocardial Infarction in Korea
Seungwoo Cha, Jin Joo Park, Sunyoung Kim, Hong-Yup Ahn, Kyungdo Han, Yookyung Lee, Won-Seok Kim, Nam-Jong Paik
Circulation Journal.2018; 82(10): 2523. CrossRef
Association between diabetes and asthma
Ji Yeon Baek, Seung Eun Lee, Kyungdo Han, Eun Hee Koh
Annals of Allergy, Asthma & Immunology.2018; 121(6): 699. CrossRef
Association between Height and Actinic Keratosis: A Nationwide Population-based Study in South Korea
Young Bok Lee, Ji Hyun Lee, Min Ji Kang, Jin-Wou Kim, Dong Soo Yu, Kyung Do Han, Yong Gyu Park
Scientific Reports.2018;[Epub] CrossRef
Effect of Institutional Case Volume on In-Hospital Mortality After Deceased Donor Liver Transplantation: A Nationwide Retrospective Cohort Study in Korea
S. Yoo, E.J. Jang, G.H. Kim, D.H. Kim, S.M. Kwon, H. Lee, C.-W. Jung, H.G. Ryu
Transplantation Proceedings.2018; 50(10): 3644. CrossRef
Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
Diabetes & Metabolism Journal.2018; 42(2): 93. CrossRef
Difference in prostate cancer incidence around sixty years: effects of age and metabolic diseases
Jin Bong Choi, Jung Ho Kim, Sung‐Hoo Hong, Kyung‐Do Han, U‐Syn Ha
Cancer Medicine.2018; 7(6): 2736. CrossRef
A nationwide population-based study of common bile duct stone recurrence after endoscopic stone removal in Korea
Byung Kyu Park, Jeong Hun Seo, Han Ho Jeon, Jong Won Choi, Sun Young Won, Yong Suk Cho, Chun Kyon Lee, Haeyong Park, Dong Wook Kim
Journal of Gastroenterology.2018; 53(5): 670. CrossRef
Estimating the impact of body mass index on bladder cancer risk: Stratification by smoking status
Jin Bong Choi, Eun Joo Lee, Kyung-Do Han, Sung-Hoo Hong, U-Syn Ha
Scientific Reports.2018;[Epub] CrossRef
Prevalence of Obesity and Incidence of Obesity-Related Comorbidities in Koreans Based on National Health Insurance Service Health Checkup Data 2006–2015
Mi Hae Seo, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong-Gyu Park, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo
Journal of Obesity & Metabolic Syndrome.2018; 27(1): 46. CrossRef
Association of Hemoglobin Concentration and Its Change With Cardiovascular and All‐Cause Mortality
Gyeongsil Lee, Seulggie Choi, Kyuwoong Kim, Jae‐Moon Yun, Joung Sik Son, Su‐Min Jeong, Sung Min Kim, Sang Min Park
Journal of the American Heart Association.2018;[Epub] CrossRef
Impact of acupuncture treatment on the lumbar surgery rate for low back pain in Korea: A nationwide matched retrospective cohort study
Wonil Koh, Kyungwon Kang, Yoon Jae Lee, Me-riong Kim, Joon-Shik Shin, Jinho Lee, Jun-Hwan Lee, Kyung-Min Shin, In-Hyuk Ha, Qinhong Zhang
PLOS ONE.2018; 13(6): e0199042. CrossRef
The influence of diabetes and antidiabetic medications on the risk of pancreatic cancer: a nationwide population-based study in Korea
Da Young Lee, Ji Hee Yu, Sanghyun Park, Kyungdo Han, Nam Hoon Kim, Hye Jin Yoo, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim, Ji A. Seo
Scientific Reports.2018;[Epub] CrossRef
Validation of Administrative Big Database for Colorectal Cancer Searched by International Classification of Disease 10th Codes in Korean: A Retrospective Big-cohort Study
Young-Jae Hwang, Nayoung Kim, Chang Yong Yun, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Il Tae Son, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee, Seon Mee Park, Dong Ho Lee
Journal of Cancer Prevention.2018; 23(4): 183. CrossRef
J-Shaped Association Between Postoperative Levothyroxine Dosage and Fracture Risk in Thyroid Cancer Patients: A Retrospective Cohort Study
Dong Wook Shin, Beomseok Suh, Hyunsun Lim, Jae Moon Yun, Sun Ok Song, Youngmin Park
Journal of Bone and Mineral Research.2018; 33(6): 1037. CrossRef
Liver cirrhosis and cancer: comparison of mortality
Wankyo Chung, Changik Jo, Woo Jin Chung, Dong Joon Kim
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The Effect of DPP-4 Inhibitors on Metabolic Parameters in Patients with Type 2 Diabetes: Eun Yeong Choe, Yongin Cho, Younjeong Choi, Yujung Yun, Hye Jin Wang, Obin Kwon, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Eun Seok Kang; Diabetes Metab J. 2014;38(3):211-219. Published online June 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.3.211

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Background

We evaluated the effects of two dipeptidyl peptidase-4 (DPP-4) inhibitors, sitagliptin and vildagliptin, on metabolic parameters in patients with type 2 diabetes mellitus.

Methods

A total of 170 type 2 diabetes patients treated with sitagliptin or vildagliptin for more than 24 weeks were selected. The patients were separated into two groups, sitagliptin (100 mg once daily, n=93) and vildagliptin (50 mg twice daily, n=77). We compared the effect of each DPP-4 inhibitor on metabolic parameters, including the fasting plasma glucose (FPG), postprandial glucose (PPG), glycated hemoglobin (HbA1c), and glycated albumin (GA) levels, and lipid parameters at baseline and after 24 weeks of treatment.

Results

The HbA1c, FPG, and GA levels were similar between the two groups at baseline, but the sitagliptin group displayed a higher PPG level (P=0.03). After 24 weeks of treatment, all of the glucose-related parameters were significantly decreased in both groups (P=0.001). The levels of total cholesterol and triglycerides were only reduced in the vildagliptin group (P=0.001), although the sitagliptin group received a larger quantity of statins than the vildagliptin group (P=0.002).The mean change in the glucose- and lipid-related parameters after 24 weeks of treatment were not significantly different between the two groups (P=not significant). Neither sitagliptin nor vildagliptin treatment was associated with a reduction in the high sensitive C-reactive protein level (P=0.714).

Conclusion

Vildagliptin and sitagliptin exert a similar effect on metabolic parameters, but vildagliptin exerts a more potent beneficial effect on lipid parameters.

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Glycemic Effectiveness of Metformin-Based Dual-Combination Therapies with Sulphonylurea, Pioglitazone, or DPP4-Inhibitor in Drug-Naïve Korean Type 2 Diabetic Patients: Young Ki Lee, Sun Ok Song, Kwang Joon Kim, Yongin Cho, Younjeong Choi, Yujung Yun, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee; Diabetes Metab J. 2013;37(6):465-474. Published online December 12, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.6.465

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Abstract PDF PubReader ePub

Background

This study compared the glycemic effectiveness of three metformin-based dual therapies according to baseline hemoglobin A1c (HbA1c) to evaluate the appropriateness of the guideline enforced by the National Health Insurance Corporation of Korea for initial medication of type 2 diabetes (T2D).

Methods

This prospective observational study was conducted across 24 weeks for drug-naïve Korean T2D patients with HbA1c greater than 7.5%. Subjects were first divided into three groups based on the agent combined with metformin (group 1, gliclazide-modified release or glimepiride; group 2, pioglitazone; group 3, sitagliptin). Subjects were also classified into three categories according to baseline HbA1c (category I, 7.5%≤HbA1c<9.0%; category II, 9.0%≤HbA1c<11.0%; category III, 11.0%≤HbA1c).

Results

Among 116 subjects, 99 subjects completed the study, with 88 subjects maintaining the initial medication. While each of the metformin-based dual therapies showed a significant decrease in HbA1c (group 1, 8.9% to 6.4%; group 2, 9.0% to 6.6%; group 3, 9.3% to 6.3%; P<0.001 for each), there was no significant difference in the magnitude of HbA1c change among the groups. While the three HbA1c categories showed significantly different baseline HbA1c levels (8.2% vs. 9.9% vs. 11.9%; P<0.001), endpoint HbA1c was not different (6.4% vs. 6.6% vs. 6.0%; P=0.051).

Conclusion

The three dual therapies using a combination of metformin and either sulfonylurea, pioglitazone, or sitagliptin showed similar glycemic effectiveness among drug-naïve Korean T2D patients. In addition, these regimens were similarly effective across a wide range of baseline HbA1c levels.

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Letter

Letter: Efficacy and Safety of Biphasic Insulin Aspart 30/70 in Type 2 Diabetes Suboptimally Controlled on Oral Antidiabetic Therapy in Korea: A Multicenter, Open-Label, Single-Arm Study (Diabetes Metab J 2013;37:117-24): Byung-Wan Lee; Diabetes Metab J. 2013;37(3):212-213. Published online June 14, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.3.212

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Responses

Response: The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone (Diabetes Metab J 2012;36:371-8): Kwang Joon Kim, Sun Ok Song, Byung-Wan Lee; Diabetes Metab J. 2013;37(1):83-84. Published online February 15, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.1.83

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Response: The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone (Diabetes Metab J 2012;36:371-8): Sun Ok Song, Kwang Joon Kim, Byung-Wan Lee; Diabetes Metab J. 2012;36(6):462-463. Published online December 12, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.6.462

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Citations

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Original Articles

The Risk of Bladder Cancer in Korean Diabetic Subjects Treated with Pioglitazone: Sun Ok Song, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee; Diabetes Metab J. 2012;36(5):371-378. Published online October 18, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.5.371

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Background

There is growing concern regarding the increased incidence of bladder cancer in diabetic patients using pioglitazone. This study aimed to investigate the association between bladder cancer and the use of pioglitazone in Korean diabetics.

Methods

This retrospective, matched case-control study included a case group (n=329) of diabetic patients with bladder cancer who presented at the Severance Hospital from November 2005 to June 2011. The control group consisted of patients without bladder cancer (1:2 ratio matching for sex and age, n=658) who were listed on the Severance Hospital diabetes registry.

Results

The percentage of subjects who had ever used pioglitazone was significantly lower in the case group than in the control group (6.4% vs. 15.0%, P<0.001). Multivariate conditional logistic analysis revealed that independent factors affecting bladder cancer were smoking (odds ratio [OR], 11.64; 95% confidence interval [CI], 6.56 to 20.66; P<0.001), coexisting cancer (OR, 6.11; 95% CI, 2.25 to 16.63; P<0.001), and hemoglobin levels (OR, 0.78; 95% CI, 0.69 to 0.88; P<0.001). The OR of the history of pioglitazone use was 2.09 and was not significantly different between the two groups (95% CI, 0.26 to 16.81; P=0.488).

Conclusion

A relationship between pioglitazone use and incidence of bladder cancer was not observed in Korean diabetic patients. This suggests that the risk for bladder cancer in Korean diabetic subjects treated with pioglitazone might be different from that of Caucasian populations. Large-scale, well-designed and multi-center studies are needed to further evaluate this relationship.

Citations

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Pioglitazone, Bladder Cancer, and the Presumption of Innocence
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A systematic review of observational studies of the association between pioglitazone use and bladder cancer
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Study design choices for evaluating the comparative safety of diabetes medications: An evaluation of pioglitazone use and risk of bladder cancer in older US adults with type‐2 diabetes
Elizabeth M. Garry, John B. Buse, Mugdha Gokhale, Jennifer L. Lund, Matthew E. Nielsen, Virginia Pate, Til Stürmer
Diabetes, Obesity and Metabolism.2019; 21(9): 2096. CrossRef
Pioglitazone use and risk of bladder cancer: a systematic literature review and meta-analysis of observational studies
Juha Mehtälä, Houssem Khanfir, Dimitri Bennett, Yizhou Ye, Pasi Korhonen, Fabian Hoti
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An updated meta-analysis of pioglitazone exposure and bladder cancer and comparison to the drug’s effect on cardiovascular disease and non-alcoholic steatohepatitis
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Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1: Hannah Seok, Ji Young Lee, Eun Mi Park, Se Eun Park, Jae Hyuk Lee, Seungtaek Lim, Byung-Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong Soo Cha; Diabetes Metab J. 2012;36(4):275-279. Published online August 20, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.4.275

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Background

The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction.

Methods

In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a high-fat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter.

Results

In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels.

Conclusion

These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.

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Glycemic Effects of Once-a-Day Rapid-Acting Insulin Analogue Addition on a Basal Insulin Analogue in Korean Subjects with Poorly Controlled Type 2 Diabetes Mellitus: Eun Yeong Choe, Yong-ho Lee, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee; Diabetes Metab J. 2012;36(3):230-236. Published online June 14, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.3.230

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Background

The present study investigates the efficacy in glycemic control by adding once-a-day glulisine to glargine as a basal plus regimen and factors influencing glycemic control with the basal plus regimen in Korean subjects with type 2 diabetes.

Methods

In the present retrospective study, subjects previously treated with the basal plus regimens for at least 6 months were reviewed. Changes in glycemic profiles and clinical parameters were evaluated.

Results

A total of 87 subjects were ultimately enrolled in this study. At baseline, mean glycated hemoglobin (A1c) and glycated albumin were 8.5% (8.0% to 9.6%) and 25.2±7.6%, respectively. After treatment with the basal plus regimen, patients had significant reductions of A1c at 6 months (0.8±0.1%, P<0.001) and their postprandial glucose levels were decreased by 48.7±10.3 mg/dL (P<0.001). Multiple logistic regression showed old age (odds ratio [OR], 1.25; 95% confidence interval [CI], 1.02 to 1.55), high initial A1c (OR, 22.21; 95% CI, 2.44 to 201.78), and lower amounts of glargine (OR, 0.85; 95% CI, 0.76 to 0.99), and glimepiride (OR, 0.23; 95% CI, 0.06 to 0.93) at baseline were independently associated with good responders whose A1c reduction was more than 0.5%.

Conclusion

The authors suggest a basal plus regimen may be effective in reducing glucose levels of subjects with old age, high initial A1c, and patients on low doses of glimepiride and glargine. Despite the use of high doses of hypoglycemic agents, elderly patients with poorly-controlled diabetes are preferred for early initiation of the basal plus regimen.

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Review

The Roles of Glycated Albumin as Intermediate Glycation Index and Pathogenic Protein: Kwang Joon Kim, Byung-Wan Lee; Diabetes Metab J. 2012;36(2):98-107. Published online April 17, 2012; DOI: https://doi.org/10.4093/dmj.2012.36.2.98

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The conventional glycemic indices used in management of diabetic patients includes A1c, fructosamine, 1,5-anhydroglucitol, and glycated albumin (GA). Among these indices, A1c is currently used as the gold standard. However, A1c cannot reflect the glycemic change over a relatively short period of time, and its accuracy is known to decrease when abnormalities in hemoglobin metabolism, such as anemia, coexist. When considering these weaknesses, there have been needs for finding a novel glycemic index for diagnosing and managing diabetes, as well as for predicting diabetic complications properly. Recently, several studies have suggested the potential of GA as an intermediate-term glycation index in covering the short-term effect of treatment. Furthermore, its role as a pathogenic protein affecting the worsening of diabetes and occurrence of diabetic complications is receiving attention as well. Therefore, in this article, we wanted to review the recent status of GA as a glycemic index and as a pathogenic protein.

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Original Articles

Dietary Oleate Has Beneficial Effects on Every Step of Non-Alcoholic Fatty Liver Disease Progression in a Methionine- and Choline-Deficient Diet-Fed Animal Model: Ji Young Lee, Jae Hoon Moon, Jong Suk Park, Byung-Wan Lee, Eun Seok Kang, Chul Woo Ahn, Hyun Chul Lee, Bong Soo Cha; Diabetes Metab J. 2011;35(5):489-496. Published online October 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.5.489

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Background

Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major cause of liver-related morbidity and mortality. The underlying mechanisms of disease progression remain poorly understood, and primary therapy of NAFLD is not yet established. We investigated the effects of dietary oleate on the development and progression of NAFLD in a methionine- and choline-deficient (MCD) diet-fed animal model.

Methods

A total of 30 C57BL/6J mice were randomly divided into three groups (n=10 in each group) and fed various experimental diets for four weeks: chow, MCD diet, or OMCD (MCD diet with oleate, 0.5 mg/g/day). Liver samples were examined for steatohepatitis and fibrosis parameters and associated genes.

Results

Additional dietary oleate dramatically reduced MCD diet-induced hepatic steatosis. Hepatic carbohydrate responsive element-binding protein was overexpressed in MCD diet-fed mice, and dietary oleate prevented this overexpression (P<0.001). Dietary oleate partially prevented MCD diet-induced serum level increases in aspartate aminotransferase and alanine aminotransferase (P<0.001, respectively). The mRNA expressions of hepatic monocyte chemoattractant protein 1, tumor necrosis factor-α and matrix metalloproteinase-9 were increased in MCD diet-fed mice, and this overexpression of inflammatory molecules was prevented by dietary oleate (P<0.001). Hepatic pericellular fibrosis was observed in MCD diet-fed mice, and dietary oleate prevented this fibrosis. Altogether, dietary oleate prevented MCD diet-induced hepatic steatosis, inflammation and fibrosis.

Conclusion

Dietary oleate has beneficial effects in every step of NAFLD development and progression and could be a nutritional option for NAFLD prevention and treatment.

Citations

Citations to this article as recorded by

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Postprandial Triglyceride Is Associated with Fasting Triglyceride and HOMA-IR in Korean Subjects with Type 2 Diabetes: Seo Hee Lee, Byung-Wan Lee, Hee Kwan Won, Jae Hoon Moon, Kwang Joon Kim, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee; Diabetes Metab J. 2011;35(4):404-410. Published online August 31, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.4.404

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Abstract PDF Supplementary Material PubReader ePub

Background

Recent studies indicate postprandial triglyceride (TG) had a better association with cardiovascular events and metabolic syndrome than fasting TG. The authors of the present study investigated the metabolic and clinical relevance of postprandial TG.

Methods

In a cross-sectional retrospective study, the authors of the present study compared fasting and postprandial TG and analyzed the relationship between postprandial TG and various demographic and metabolic parameters in 639 Korean subjects with type 2 diabetes (T2D, group I, n=539) and impaired fasting glucose (IFG, group II, n=100) after ingestion of a standardized liquid meal (total 500 kcal, 17.5 g fat, 68.5 g carbohydrate, and 17.5 g protein).

Results

Fasting and postprandial TG were significantly correlated (r=0.973, r=0.937, P<0.001) in group I and II, respectively. Of the variables, total cholesterol, waist circumference and body mass index were significantly correlated with fasting and postprandial TG in both groups. Only postprandial TG showed a significant correlation with glucose metabolic parameters (e.g., postprandial glucose, homeostatic model assessment of insulin resistance [HOMA-IR], and fasting C-peptide) in subjects with T2D. Multiple regression analysis showed fasting TG and HOMA-IR could be predictable variables for postprandial TG in subjects with T2D.

Conclusion

Postprandial TG was very strongly correlated with fasting TG. The authors of the present study suggest insulin resistance may be more associated with postprandial TG than fasting TG in Korean T2D patients on a low-fat diet.

Citations

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