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Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
Leigang Jin, Zhuofeng Lin, Aimin Xu
Diabetes Metab J. 2016;40(1):22-31.   Published online January 29, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.22
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  • 36 Web of Science
  • 32 Crossref
AbstractAbstract PDFPubReader   

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects against atherosclerosis. Circulating levels of FGF21 are elevated in patients with atherosclerosis, macrovascular and microvascular complications of diabetes, possibly due to a compensatory upregulation. In apolipoprotein E-deficient mice, formation of atherosclerotic plaques is exacerbated by genetic depletion of FGF21, but is attenuated upon replenishment with recombinant FGF21. However, the blood vessel is not the direct target of FGF21, and the antiatherosclerotic activity of FGF21 is attributed to its actions in adipose tissues and liver. In adipocytes, FGF21 promotes secretion of adiponectin, which in turn acts directly on blood vessels to reduce endothelial dysfunction, inhibit proliferation of smooth muscle cells and block conversion of macrophages to foam cells. Furthermore, FGF21 suppresses cholesterol biosynthesis and attenuates hypercholesterolemia by inhibiting the transcription factor sterol regulatory element-binding protein-2 in hepatocytes. The effects of FGF21 on elevation of adiponectin and reduction of hypercholesterolemia are also observed in a phase-1b clinical trial in patients with obesity and diabetes. Therefore, FGF21 exerts its protection against atherosclerosis by fine-tuning the interorgan crosstalk between liver, brain, adipose tissue, and blood vessels.

Citations

Citations to this article as recorded by  
  • Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications
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    Expert Opinion on Investigational Drugs.2023; 32(6): 451.     CrossRef
  • The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease
    Meichao Cai, Dongsheng Zhao, Xiao Han, Shuang Han, Wenxin Zhang, Zhennan Zang, Chenchen Gai, Rong Rong, Tian Gao
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
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    Cardiovascular Research.2022; 118(2): 489.     CrossRef
  • Relationship between Serum FGF21 and vWF Expression and Carotid Atherosclerosis in Elderly Patients with Hypertension
    Jing Bian, Lairong Chen, Qin Li, Yunfeng Zhao, Delu Yin, Shanhong Sun, Bhagyaveni M.A
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
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    Wei Xie, Dan Li, Yaru Shi, Ning Yu, Yu Yan, Yingchao Zhang, Qiongli Yu, Yulin Li, Jie Du, Zhuofeng Lin, Fan Wu
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    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Current understanding and controversies on the clinical implications of fibroblast growth factor 21
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    Critical Reviews in Clinical Laboratory Sciences.2021; 58(5): 311.     CrossRef
  • The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development
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  • Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy
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    Acta Biomaterialia.2021; 130: 395.     CrossRef
  • Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model
    Hyo Jin Maeng, Gha Young Lee, Jae Hyun Bae, Soo Lim
    International Journal of Molecular Sciences.2020; 21(18): 6836.     CrossRef
  • The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
    Leiluo Geng, Karen S. L. Lam, Aimin Xu
    Nature Reviews Endocrinology.2020; 16(11): 654.     CrossRef
  • Two-hundred-liter scale fermentation, purification of recombinant human fibroblast growth factor-21, and its anti-diabetic effects on ob/ob mice
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  • Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?
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  • Heparin‐poloxamer hydrogel‐encapsulated rhFGF21 enhances wound healing in diabetic mice
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    The FASEB Journal.2019; 33(9): 9858.     CrossRef
  • Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes
    Saeed Yafei, Fathy Elsewy, Eman Youssef, Mohammed Ayman, Mohamed El-Shafei
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 882.     CrossRef
  • Myokines in metabolic homeostasis and diabetes
    Jürgen Eckel
    Diabetologia.2019; 62(9): 1523.     CrossRef
  • Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
    Wei Wei, Xiao-Xue Li, Ming Xu
    Atherosclerosis.2019; 289: 132.     CrossRef
  • LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
    Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho, Partha Mukhopadhyay
    PLOS ONE.2018; 13(2): e0192146.     CrossRef
  • Relationship of Selected Adipokines with Markers of Vascular Damage in Patients with Type 2 Diabetes
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    Metabolic Syndrome and Related Disorders.2018; 16(5): 246.     CrossRef
  • Serum FGF21 Is Associated with Future Cardiovascular Events in Patients with Coronary Artery Disease
    Yun Shen, Xueli Zhang, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
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  • Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
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    Journal of Lipid and Atherosclerosis.2018; 7(1): 42.     CrossRef
  • Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages
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    Biomedicine & Pharmacotherapy.2018; 108: 1825.     CrossRef
  • Chip‐based high resolution tandem mass spectrometric determination of fibroblast growth factor—chondroitin sulfate disaccharides noncovalent interaction
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  • Fibroblast growth factor 21 – a key player in cardiovascular disorders?
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  • The role of fibroblast growth factor 21 in atherosclerosis
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