Type 2 diabetes mellitus (T2DM) is a current global health priority and Asia is the epicenter of this epidemic disease. Unlike in the west, where older population is most affected, the burden of diabetes in Asian countries is disproportionately high in young to middle-age adults. The incidence of diabetic nephropathy is alarmingly high in patients with early onset T2DM, especially in those with poor glycemic control. How to control this chronic and debilitating disease is currently a very important health issue in Asia. Bariatric surgery has proven successful in treating not just obesity but also T2DM in morbid obese patients (body mass index [BMI] >35 kg/m²). Gastrointestinal metabolic surgery recently has been proposed as a new treatment modality for obesity related T2DM for patients with BMI <35 kg/m². Many studies from Asia reported promising results of metabolic surgery to treat obese patients with T2DM which is not well controlled. It has been demonstrated that changes in gastrointestinal hormone secretion after gastrointestinal surgery would favor an early improvement of T2DM in Asians. New procedures have also been designed and proposed specifically for the treatment of diabetes in Asia. This article examines clinical trial data and accepted algorithms with a view toward elucidating the application of metabolic surgery for the treatment of T2DM in the Asia. We propose a systematic approach to surgical treatment, addressing current evidences, patient selection, procedure of choice, and timing and guideline for new procedures.

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Citations to this article as recorded by  

• Insulin resistance levels predicted metabolic improvement and weight loss after metabolic surgery in Chinese patients with type 2 diabetes
  Yaoquan Cao, Ping Luo, Haibo Tang, Pengzhou Li, Guohui Wang, Weizheng Li, Zhi Song, Zhihong Su, Xulong Sun, Xianhao Yi, Zhibing Fu, Beibei Cui, Shaihong Zhu, Liyong Zhu
  Surgery for Obesity and Related Diseases.2024; 20(1): 80.     CrossRef
• Long‐term outcomes of metabolic surgery in overweight and obese patients with type 2 diabetes in Asia
  Yu‐Min Huang, Yen‐Kuang Lin, Wei‐Jei Lee, Kyoung Yul Hur, Kazunori Kasama, Anton Kui Sing Cheng, Ming‐Hsien Lee, Simon Kin‐Hung Wong, Tien‐Chou Soong, Kuo‐Ting Lee, Davide Lomanto, Muffazal Lakdawala, Yen‐Hao Su, Weu Wang
  Diabetes, Obesity and Metabolism.2021; 23(3): 742.     CrossRef
• Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
  Chang Ho Ahn, Eun Hye Choi, Hyunjung Lee, Woochan Lee, Jong-Il Kim, Young Min Cho
  Scientific Reports.2021;[Epub]     CrossRef
• Insulin Resistance Remission Following Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy in Chinese Type 2 Diabetes Mellitus Patients With a Body Mass Index of 27.5–32.5 kg/m2
  Ping Luo, Yaoquan Cao, Pengzhou Li, Guohui Wang, Zhi Song, Weizheng Li, Zhihong Su, Hui Zhou, Xianhao Yi, Zhibing Fu, Xulong Sun, Haibo Tang, Beibei Cui, Qianqian Yu, Liyong Zhu, Shaihong Zhu
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Pre- and postoperative respiratory muscle strength, body mass index and fasting glucose profile of patients with type 2 diabetes mellitus submitted to metabolic surgery
  Ariana de Melo Tosta, Marisa de Carvalho Borges, Élida Mara Carneiro da Silva, Alex Augusto da Silva, Eduardo Crema
  Fisioterapia em Movimento.2020;[Epub]     CrossRef
• Outcomes After Metabolic Surgery in Asians—a Meta-analysis
  Danson Yeo, Charleen Yeo, Tze Yi Low, Saleem Ahmed, Sheena Phua, Aung Myint Oo, Jaideepraj Rao, Aaryan Koura, Kavita Venkataraman, Sanghvi Kaushal
  Obesity Surgery.2019; 29(1): 114.     CrossRef
• Diabetes resolution after one anastomosis gastric bypass
  Adam Abu-Abeid, Yonatan Lessing, Niv Pencovich, Danit Dayan, Joseph M. Klausner, Subhi Abu-Abeid
  Surgery for Obesity and Related Diseases.2018; 14(2): 181.     CrossRef
• Laparoscopic metabolic surgery for the treatment of type 2 diabetes in Asia: a scoping review and evidence-based analysis
  Zhiyong Dong, Sheikh Mohammed Shariful Islam, Ashley M. Yu, Rui Qu, Bingsheng Guan, Junchang Zhang, Zhao Hong, Cunchuang Wang
  BMC Surgery.2018;[Epub]     CrossRef
• Clinical Practice Recommendations for the Management of Obesity in the United Arab Emirates
  Salahedeen Abusnana, Mohammad Fargaly, Shaima Hasan Alfardan, Fatema Hasan Al Hammadi, Alaaeldin Bashier, Ghaida Kaddaha, Barbara McGowan, Rita Nawar, Amena Sadiya
  Obesity Facts.2018; 11(5): 413.     CrossRef
• Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2
  Ying-Xu Li, Deng-Hua Fang, Tian-Xi Liu
  Medicine.2018; 97(31): e11537.     CrossRef
• Comparison of Great Curvature Plication with Duodenal-Jejunal Bypass (GCP-DJB) and Sleeve Gastrectomy (SG) on Metabolic Indices and Gut Hormones in Type 2 Diabetes Mellitus Rats
  Nian-Cun Qiu, Wei Li, Miao-E Liu, Xiao-Xia Cen, Cheng-Xiang Shan, Wei Zhang, Qing Liu, Yang Wang, Ya-Ting Zhu, Ming Qiu
  Obesity Surgery.2018; 28(12): 4014.     CrossRef
• Evolution of Diabetes Care in Hong Kong: From the Hong Kong Diabetes Register to JADE-PEARL Program to RAMP and PEP Program
  Ivy H.Y. Ng, Kitty K.T. Cheung, Tiffany T.L. Yau, Elaine Chow, Risa Ozaki, Juliana C.N. Chan
  Endocrinology and Metabolism.2018; 33(1): 17.     CrossRef
• Ethnicity Does Not Influence Glycemic Outcomes or Diabetes Remission After Sleeve Gastrectomy or Gastric Bypass in a Multiethnic Asian Cohort
  Phong Ching Lee, Kwang Wei Tham, Sonali Ganguly, Hong Chang Tan, Alvin Kim Hock Eng, John B. Dixon
  Obesity Surgery.2018; 28(6): 1511.     CrossRef
• Effects of GABAB receptor activation on spatial cognitive function and hippocampal neurones in rat models of type 2 diabetes mellitus
  Xiao-Jun Cai, Lei Wang, Chun-Mei Hu
  Bioscience Reports.2018;[Epub]     CrossRef
• Metabolic surgery ameliorates cardiovascular risk in obese diabetic patients: Influence of different surgical procedures
  Jih-Hua Wei, Ruey-Hsing Chou, Po-Hsun Huang, Wei-Jei Lee, Shu-Chun Chen, Shing-Jong Lin
  Surgery for Obesity and Related Diseases.2018; 14(12): 1832.     CrossRef
• Pulmonary function evaluation in type 2 diabetes mellitus patients submitted to metabolic surgery
  Ariana de Melo Tosta, Marisa de Carvalho Borges, Élida Mara Carneiro da Silva, Tharsus Dias Takeuti, Júverson Alves Terra Júnior, Eduardo Crema
  Fisioterapia em Movimento.2018;[Epub]     CrossRef

Obesity has quickly become a worldwide pandemic, causing major adverse health outcomes such as dyslipidemia, type 2 diabetes mellitus, cardiovascular disease and cancers. Obesity-induced insulin resistance is the key for developing these metabolic disorders, and investigation to understand the molecular mechanisms involved has been vibrant for the past few decades. Of these, low-grade chronic inflammation is suggested as a critical concept in the development of obesity-induced insulin resistance, and the anti-inflammatory effect of nitric oxide (NO) signaling has been reported to be linked to improvement of insulin resistance in multiple organs involved in glucose metabolism. Recently, a body of evidence suggested that vasodilatory-stimulated phosphoprotein (VASP), a downstream mediator of NO signaling plays a crucial role in the anti-inflammatory effect and improvement of peripheral insulin resistance. These preclinical studies suggest that NO/VASP signaling could be an ideal therapeutic target in the treatment of obesity-related metabolic dysfunction. In this review, we introduce studies that investigated the protective role of NO/VASP signaling against obesity-related inflammation and insulin resistance in various tissues.

Citations

Citations to this article as recorded by  

• Hippocampal proteomic changes in high-fat diet-induced obese mice associated with memory decline
  Ping Lu, Cun-Xiu Gao, Fei-Jian Luo, Yu-Ting Huang, Mei-Mei Gao, Yue-Sheng Long
  The Journal of Nutritional Biochemistry.2024; 125: 109554.     CrossRef
• Leptina, obesidad y enfermedades cardiovasculares
  Jorly Mejia-Montilla , Nadia Reyna-Villasmil, Andreina Fernández-Ramírez, Eduardo Reyna-Villasmil
  Revista Repertorio de Medicina y Cirugía.2023; 32(3): 218.     CrossRef
• Urinary and circulatory netrin-1 as biomarker in diabetes and its related complications: a systematic review and meta-analysis
  Amir Hossein Behnoush, Amirmohammad Khalaji, Zahra Shokri Varniab, Afshin Rahbarghazi, Elahe Amini, Aleksandra Klisic
  Endocrine.2023;[Epub]     CrossRef
• Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D
  Qing‐Ling Quan, Kyeong‐No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee
  Photodermatology, Photoimmunology & Photomedicine.2023; 39(6): 573.     CrossRef
• Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model
  Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Type 2 Diabetes Complicated With Heart Failure: Research on Therapeutic Mechanism and Potential Drug Development Based on Insulin Signaling Pathway
  Hui Ye, Yanan He, Chuan Zheng, Fang Wang, Ming Yang, Junzhi Lin, Runchun Xu, Dingkun Zhang
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Effect of low-dose tadalafil once daily on glycemic control in patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, placebo-controlled pilot study
  Min-Kyung Lee, Jae-Hyuk Lee, Seo-Young Sohn, Seo Yeon Lee, Tae-Yoong Jeong, Sae Chul Kim
  Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
• In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot
  Yingzheng Zhao, Lanzi Luo, Lantian Huang, Yingying Zhang, Mengqi Tong, Hanxiao Pan, Jianxun Shangguan, Qing Yao, Shihao Xu, Helin Xu
  Journal of Controlled Release.2022; 350: 93.     CrossRef
• Amelioration effect of black seed oil against high‐fat diet‐induced obesity in rats through Nrf2/HO‐1 pathway
  Nada F. Abo El‐Magd, Mohamed El‐Mesery, Amro El‐Karef, Mamdouh M. El‐Shishtawy
  Journal of Food Biochemistry.2021;[Epub]     CrossRef
• An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
  John P. Hanrahan, Jelena P. Seferovic, James D. Wakefield, Phebe J. Wilson, Jennifer G. Chickering, Joon Jung, Kenneth E. Carlson, Daniel P. Zimmer, Andrew L. Frelinger, Alan D. Michelson, Linda Morrow, Michael Hall, Mark G. Currie, G. Todd Milne, Albert
  Diabetologia.2020; 63(4): 733.     CrossRef
• Advantages of Phosphodiesterase Type 5 Inhibitors in the Management of Glucose Metabolism Disorders: A Clinical and Translational Issue
  Cristina Antinozzi, Paolo Sgrò, Luigi Di Luigi
  International Journal of Endocrinology.2020; 2020: 1.     CrossRef
• Association of endothelial dysfunction with incident prediabetes, type 2 diabetes and related traits: the KORA F4/FF4 study
  Marie-Theres Huemer, Cornelia Huth, Florian Schederecker, Stefanie J Klug, Christa Meisinger, Wolfgang Koenig, Wolfgang Rathmann, Annette Peters, Barbara Thorand
  BMJ Open Diabetes Research & Care.2020; 8(1): e001321.     CrossRef
• Embelin from Embelia ribes ameliorates oxidative stress and inflammation in high-fat diet-fed obese C57BL/6 mice
  Priyanka Bansal, Uma Bhandari, Sayeed Ahmad
  Pharmacognosy Magazine.2020; 16(5): 443.     CrossRef
• Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
  Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
  Scientific Reports.2019;[Epub]     CrossRef
• Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment
  Sunghwan Suh, Kwang-Won Kim
  Diabetes & Metabolism Journal.2019; 43(6): 733.     CrossRef
• Antioxidant, antihyperglycemic, and antidiabetic activity of Apis mellifera bee tea
  Janielle da Silva Melo da Cunha, Tamaeh Monteiro Alfredo, Jéssica Maurino dos Santos, Valter Vieira Alves Junior, Luiza Antas Rabelo, Emerson Silva Lima, Ana Paula de Araújo Boleti, Carlos Alexandre Carollo, Edson Lucas dos Santos, Kely de Picoli Souza, M
  PLOS ONE.2018; 13(6): e0197071.     CrossRef
• Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes
  Jisook Yim, Gyuri Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jeong-Ho Kim, Jin Won Cho, Sang-Guk Lee, Yong-ho Lee
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Glycyrrhizin ameliorates high fat diet-induced obesity in rats by activating NrF2 pathway
  Nada F. Abo El-Magd, Mohamed El-Mesery, Amro El-Karef, Mamdouh M. El-Shishtawy
  Life Sciences.2018; 193: 159.     CrossRef
• cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation
  Andras Franko, Marketa Kovarova, Susanne Feil, Robert Feil, Robert Wagner, Martin Heni, Alfred Königsrainer, Marc Ruoß, Andreas K. Nüssler, Cora Weigert, Hans-Ulrich Häring, Stefan Z. Lutz, Andreas Peter
  Metabolism.2018; 88: 22.     CrossRef

Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed "glycemic memory." In response to chronically elevated glucose levels, a number of studies have identified molecular targets of the glucose-mediated protein posttranslational modification by the addition of an O-linked N-acetylglucosamine to impair contractility, calcium sensitivity, and mitochondrial protein function. Additionally, elevated glucose contributes to dysfunction in coupling glycolysis to glucose oxidation, pentose phosphate pathway, and polyol pathway. Therefore, in the "sweetened" environment associated with hyperglycemia, there are a number of pathways contributing to increased susceptibly to "breaking" the heart of diabetics. In this review we will discuss the unique contribution of glucose to heart disease and recent advances in defining mechanisms of action.

Citations

Citations to this article as recorded by  

• Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
  Shuaijie Lou, Weiwei Zhu, Tianxiang Yu, Qianhui Zhang, Minxiu Wang, Leiming Jin, Yongqiang Xiong, Jiachen Xu, Qinyan Wang, Gaozhi Chen, Guang Liang, Xiang Hu, Wu Luo
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(5): 167140.     CrossRef
• O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
  Stefan Norlin, Jan Axelsson, Madelene Ericsson, Helena Edlund
  Communications Biology.2023;[Epub]     CrossRef
• The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
  Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
  Basic Research in Cardiology.2023;[Epub]     CrossRef
• Silibinin ameliorates the cardiovascular oxidative and inflammatory effects of type-2-diabetic rats exposed to air particulate matter
  Olamide O. Awolaja, Akeem O. Lawal, Ibukun M. Folorunso, Olusola O. Elekofehinti, Haruna I. Umar
  Polycyclic Aromatic Compounds.2023; 43(7): 6570.     CrossRef
• The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
  Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
  Nutrients.2023; 15(7): 1660.     CrossRef
• The role of CD36 in cardiovascular disease
  Hongyang Shu, Yizhong Peng, Weijian Hang, Jiali Nie, Ning Zhou, Dao Wen Wang
  Cardiovascular Research.2022; 118(1): 115.     CrossRef
• The world congress on insulin resistance, diabetes, and cardiovascular disease (WCIRDC)
  Zachary Bloomgarden
  Journal of Diabetes.2022; 14(3): 163.     CrossRef
• Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions
  Karin J. Bosma, Monica Ghosh, Spencer R. Andrei, Lin Zhong, Jennifer C. Dunn, Valerie F. Ricciardi, Juliann B. Burkett, Antonis K. Hatzopoulos, Derek S. Damron, Maureen Gannon
  Physiological Reports.2022;[Epub]     CrossRef
• The efficacy and safety of traditional Chinese medicine treating diabetic cardiomyopathy: A protocol for systematic review and meta-analysis
  Shuo Han, Yuan Hou, Huaman Liu, Quanlin Zhao
  Medicine.2022; 101(47): e31269.     CrossRef
• High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle
  Priyanka Parijat, Laszlo Kondacs, Alexander Alexandrovich, Mathias Gautel, Alexander J. A. Cobb, Thomas Kampourakis
  ACS Chemical Biology.2021; 16(1): 225.     CrossRef
• Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling
  Fan Ying, Hao Liu, Eva Hoi Ching Tang, Ishan Lakhani, Ningning Liu, Zhengyuan Xia, Shiming Liu
  Biochemical and Biophysical Research Communications.2021; 548: 196.     CrossRef
• Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage
  Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama, Chigusa Kikuchi, Ayako Furukawa, Kentaro Nagamine, Takamitsu Hori, Tamihide Matsunaga
  Biomolecules.2021; 11(3): 387.     CrossRef
• Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II
  Afshan Kaleem, Sabahat Javed, Nayab Rehman, Roheena Abdullah, Mehwish Iqtedar, Mohammad Nauman Aftab, Daniel C. Hoessli, Ikram-Ul Haq
  Protein & Peptide Letters.2021; 28(3): 333.     CrossRef
• Diabetes and Heart Failure: Multi-Omics Approaches
  Akram Tayanloo-Beik, Peyvand Parhizkar Roudsari, Mostafa Rezaei-Tavirani, Mahmood Biglar, Ozra Tabatabaei-Malazy, Babak Arjmand, Bagher Larijani
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Asymptomatic Diabetic Cardiomyopathy: an Underrecognized Entity in Type 2 Diabetes
  Ana Maria Stanton, Muthiah Vaduganathan, Lee-Shing Chang, Alexander Turchin, James L. Januzzi, Vanita R. Aroda
  Current Diabetes Reports.2021;[Epub]     CrossRef
• Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
  Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
  Journal of the American Heart Association.2020;[Epub]     CrossRef
• Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes
  Darnel Prakoso, Miles J. De Blasio, Mitchel Tate, Helen Kiriazis, Daniel G. Donner, Hongwei Qian, David Nash, Minh Deo, Kate L. Weeks, Laura J. Parry, Paul Gregorevic, Julie R. McMullen, Rebecca Helen Ritchie
  American Journal of Physiology-Heart and Circulatory Physiology.2020; 318(4): H840.     CrossRef
• The Potential Role of MicroRNA in Diabetic Cardiomyopathy
  Jin Hwa Kim
  Diabetes & Metabolism Journal.2020; 44(1): 54.     CrossRef
• Re-balancing cellular energy substrate metabolism to mend the failing heart
  Jan F.C. Glatz, Miranda Nabben, Martin E. Young, P. Christian Schulze, Heinrich Taegtmeyer, Joost J.F.P. Luiken
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(5): 165579.     CrossRef
• The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy
  Maayan Waldman, Michael Arad, Nader G. Abraham, Edith Hochhauser
  Antioxidants & Redox Signaling.2020; 32(17): 1273.     CrossRef
• miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway
  Yu Li, Jing‑Zhu Duan, Qian He, Chong‑Quan Wang
  Molecular Medicine Reports.2020;[Epub]     CrossRef
• Disruption of energy utilization in diabetic cardiomyopathy; a mini review
  Shinsuke Nirengi, Carmem Peres Valgas da Silva, Kristin I Stanford
  Current Opinion in Pharmacology.2020; 54: 82.     CrossRef
• Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy
  Yogi Umbarawan, Ryo Kawakami, Mas Rizky A. A. Syamsunarno, Norimichi Koitabashi, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Hiroaki Sunaga, Hiroki Matsui, Masahiko Kurabayashi, Tatsuya Iso
  Scientific Reports.2020;[Epub]     CrossRef
• Metabolomics biomarkers and the risk of overall mortality and ESRD in CKD: Results from the Progredir Cohort
  Silvia M. Titan, Gabriela Venturini, Kallyandra Padilha, Alessandra C. Goulart, Paulo A. Lotufo, Isabela J. Bensenor, Jose E. Krieger, Ravi I. Thadhani, Eugene P. Rhee, Alexandre C. Pereira, Vivekanand Jha
  PLOS ONE.2019; 14(3): e0213764.     CrossRef
• Chronic hyperglycemia as a risk factor in implant therapy
  Fawad Javed, Georgios E. Romanos
  Periodontology 2000.2019; 81(1): 57.     CrossRef
• Recent advances in the pathogenesis of microvascular complications in diabetes
  Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
  Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
• Nutrient regulation of signaling and transcription
  Gerald W. Hart
  Journal of Biological Chemistry.2019; 294(7): 2211.     CrossRef
• Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease
  Takanobu Takata, Akiko Sakasai-Sakai, Tadashi Ueda, Masayoshi Takeuchi
  Scientific Reports.2019;[Epub]     CrossRef
• Effects of Exercise to Improve Cardiovascular Health
  Kelsey Pinckard, Kedryn K. Baskin, Kristin I. Stanford
  Frontiers in Cardiovascular Medicine.2019;[Epub]     CrossRef
• A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart
  Desiree Abdurrachim, Chern Chiuh Woo, Xing Qi Teo, Wei Xin Chan, George K. Radda, Philip Teck Hock Lee
  Scientific Reports.2019;[Epub]     CrossRef
• Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose
  Simon Ducheix, Jocelyne Magré, Bertrand Cariou, Xavier Prieur
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Proteomics of the Rat Myocardium during Development of Type 2 Diabetes Mellitus Reveals Progressive Alterations in Major Metabolic Pathways
  Anders Valdemar Edhager, Jonas Agerlund Povlsen, Bo Løfgren, Hans Erik Bøtker, Johan Palmfeldt
  Journal of Proteome Research.2018; 17(7): 2521.     CrossRef
• Protective effects of astaxanthin on diabetic cardiomyopathy in rats
  Bingshan Zhang, Di Xu
  CyTA - Journal of Food.2018; 16(1): 909.     CrossRef
• Au cœur de la cardiomyopathie diabétique
  Alexandre Lugat, Michael Joubert, Bertrand Cariou, Xavier Prieur
  médecine/sciences.2018; 34(6-7): 563.     CrossRef
• Redox imbalance stress in diabetes mellitus: Role of the polyol pathway
  Liang‐jun Yan
  Animal Models and Experimental Medicine.2018; 1(1): 7.     CrossRef
• Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
  Othmar Moser, Max L. Eckstein, Olivia McCarthy, Rachel Deere, Stephen C. Bain, Hanne L. Haahr, Eric Zijlstra, Tim Heise, Richard M. Bracken, Petter Bjornstad
  PLOS ONE.2018; 13(4): e0194750.     CrossRef
• Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
  Tae Hee Ko, Jubert C. Marquez, Hyoung Kyu Kim, Seung Hun Jeong, SungRyul Lee, Jae Boum Youm, In Sung Song, Dae Yun Seo, Hye Jin Kim, Du Nam Won, Kyoung Im Cho, Mun Gi Choi, Byoung Doo Rhee, Kyung Soo Ko, Nari Kim, Jong Chul Won, Jin Han
  Pflügers Archiv - European Journal of Physiology.2018; 470(2): 263.     CrossRef
• Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy – a hypothesis
  Kaviyarasi Renu, V.G. Abilash, P.B. Tirupathi Pichiah, Thabassum Akthar Syeda, Sankarganesh Arunachalam
  Asian Pacific Journal of Tropical Biomedicine.2017; 7(11): 1041.     CrossRef
• Proteome profiling in the aorta and kidney of type 1 diabetic rats
  Moustafa Al Hariri, Mohamad Elmedawar, Rui Zhu, Miran A. Jaffa, Jingfu Zhao, Parvin Mirzaei, Adnan Ahmed, Firas Kobeissy, Fuad N. Ziyadeh, Yehia Mechref, Ayad A. Jaffa, Michael Bader
  PLOS ONE.2017; 12(11): e0187752.     CrossRef

Hypoglycemia has been considered as a major barrier to achieving the proper glycemic target in type 2 diabetes mellitus patients. In particular, severe hypoglycemia (SH), which is defined as a hypoglycemic episode requiring the assistance of another person to raise the patient's glucose level, is a serious complication of diabetes because of its possible fatal outcomes. Recently, the recommendations for diabetes care have emphasized a patient-centered approach, considering the individualized patient factors including hypoglycemia. Many studies have been performed which analyzed the risk factors and clinical outcomes for SH. From the studies, researchers recommend that targeting a less stringent glycosylated hemoglobin level and selecting a safer class of drugs for hypoglycemia are appropriate for patients with a high risk of SH. Also, careful clinical attention to prevent hypoglycemia, including intensive education, is necessary to minimize the risk of SH and SH-related fatal outcomes.

Citations

Citations to this article as recorded by  

• Guideline for the Management of Diabetes Mellitus in the Elderly in China (2024 Edition)
  Lixin Guo, Xinhua Xiao
  AGING MEDICINE.2024; 7(1): 5.     CrossRef
• Risk factors and adverse outcomes of hypoglycemia in older patients with type 2 diabetes mellitus (review)
  S. V. Bulgakova, P. Ya. Merzlova, D. P. Kurmaev, E. V. Treneva
  Russian Journal of Geriatric Medicine.2024; (1): 30.     CrossRef
• A novel electronic health record-based, machine-learning model to predict severe hypoglycemia leading to hospitalizations in older adults with diabetes: A territory-wide cohort and modeling study
  Mai Shi, Aimin Yang, Eric S. H. Lau, Andrea O. Y. Luk, Ronald C. W. Ma, Alice P. S. Kong, Raymond S. M. Wong, Jones C. M. Chan, Juliana C. N. Chan, Elaine Chow
  PLOS Medicine.2024; 21(4): e1004369.     CrossRef
• Evaluation of Computer-Based Insulin Infusion Algorithm Compared With a Paper-Based Protocol in the Treatment of Diabetic Ketoacidosis
  Heather M. Martinez, Kirsten Elwood, Chris Werth, Preeyaporn Sarangarm
  Journal of Pharmacy Technology.2023; 39(2): 82.     CrossRef
• A prediction model for assessing hypoglycemia risk in critically ill patients with sepsis
  Hongyang Gao, Yang Zhao
  Heart & Lung.2023; 62: 43.     CrossRef
• Systematic Literature Review and Indirect Treatment Comparison of Three Ready-to-Use Glucagon Treatments for Severe Hypoglycemia
  Marga Giménez, Kamlesh Khunti, Munehide Matsuhisa, Suresh Chenji, Kristen Syring, Yu Yan
  Diabetes Therapy.2023; 14(11): 1757.     CrossRef
• Use of Second-Generation Basal Insulin Gla-300 in Special Populations: A Narrative Mini-Review
  Sujoy Ghosh, Sanjay Kalra, Ganapathi Bantwal, Rakesh Kumar Sahay
  Current Diabetes Reviews.2023;[Epub]     CrossRef
• A Cross-Sectional study on risk factors for severe hypoglycemia among Insulin-Treated elderly type 2 diabetes Mellitus (T2DM) patients in Singapore
  Michelle Shi Min Ko, Wai Kit Lee, Li Chang Ang, Su-Yen Goh, Yong Mong Bee, Ming Ming Teh
  Diabetes Research and Clinical Practice.2022; 185: 109236.     CrossRef
• Role of polyphenols in combating Type 2 Diabetes and insulin resistance
  Moyad Shahwan, Fahad Alhumaydhi, Ghulam Md. Ashraf, Prince M.Z. Hasan, Anas Shamsi
  International Journal of Biological Macromolecules.2022; 206: 567.     CrossRef
• Real-World Effectiveness and Safety of Insulin Glargine 300 U/mL in Insulin-Naïve People with Type 2 Diabetes: the ATOS Study
  Gagik R. Galstyan, Amir Tirosh, Hernando Vargas-Uricoechea, Maria Aileen Mabunay, Mathieu Coudert, Mubarak Naqvi, Valerie Pilorget, Niaz Khan
  Diabetes Therapy.2022; 13(6): 1187.     CrossRef
• External validation and clinical application of the predictive model for severe hypoglycemia
  Jae-Seung Yun, Kyungdo Han, Soo-Yeon Choi, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Time below range: Retrospective continuous glucose monitoring analysis to detect hypoglycemia in routine clinical practice
  Manoj Chawla, Purvi Chawla, Banshi Saboo, Jothydev Kesavadev, Amit Gupta, Rakesh Parikh
  International Journal of Diabetes and Technology.2022; 1(2): 69.     CrossRef
• Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
  Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
  Scientific Reports.2021;[Epub]     CrossRef
• Severe Hypoglycemia Risk With Long-Acting Insulin Analogs vs Neutral Protamine Hagedorn Insulin
  Marie C. Bradley, Yoganand Chillarige, Hana Lee, Xiyuan Wu, Shruti Parulekar, Stella Muthuri, Michael Wernecke, Thomas E. MaCurdy, Jeffrey A. Kelman, David J. Graham
  JAMA Internal Medicine.2021; 181(5): 598.     CrossRef
• Hypoglycemia Among Type 1 Diabetes Patients After Insulin Use in Southwest Ethiopia
  Tewodros Yosef
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• The use of statins in the elderly is associated with less severe hypoglycemia in patient with diabetes
  Xavier Dubucs, Jean-Baptiste Julla, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Jean-François Gautier
  Diabetes Research and Clinical Practice.2020; 162: 108034.     CrossRef
• Effects of Co‐administration of Sulfonylureas and Antimicrobial Drugs on Hypoglycemia in Patients with Type 2 Diabetes Using a Case‐Crossover Design
  Sera Lee, Miyoung Ock, Hun‐Sung Kim, Hyunah Kim
  Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.2020; 40(9): 902.     CrossRef
• Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model
  Aline Zbinden, Julia Marzi, Katharina Schlünder, Christopher Probst, Max Urbanczyk, Scott Black, Eva M. Brauchle, Shannon L. Layland, Udo Kraushaar, Garry Duffy, Katja Schenke-Layland, Peter Loskill
  Matrix Biology.2020; 85-86: 205.     CrossRef
• Associations Between the Knowledge of Different Food Categories and Glycemia in Chinese Adult Patients With Type 2 Diabetes
  Yuan Xue, Xiao-Yan Zhang, Hui-Juan Zhou, Omorogieva Ojo, Qi Wang, Li-Li Wang, Qing Jiang, Ting Liu, Xiao-Hua Wang
  Clinical Nursing Research.2020; 29(5): 313.     CrossRef
• Deterioration of Sleep Quality According to Glycemic Status
  Myung Haeng Hur, Mi-Kyoung Lee, Kayeon Seong, Jun Hwa Hong
  Diabetes & Metabolism Journal.2020; 44(5): 679.     CrossRef
• Higher versus standard starting dose of insulin glargine 100 U/mL in overweight or obese Chinese patients with type 2 diabetes: Results of a multicentre, open‐label, randomized controlled trial (BEYOND VII)
  Linong Ji, Hailong Wan, Binhong Wen, Xueying Wang, Junfen Wang, Rongwen Bian, Wuyan Pang, Jian Tian, Yan Wang, Fang Bian, Zhengnan Gao, Alex Condoleon, Wei Feng, Xia Zhang, Nan Cui
  Diabetes, Obesity and Metabolism.2020; 22(5): 838.     CrossRef
• Outcomes for Inappropriate Renal Dose Adjustment of Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes Mellitus: Population-Based Study
  Sangmo Hong, Kyungdo Han, Cheol-Young Park
  Mayo Clinic Proceedings.2020; 95(1): 101.     CrossRef
• Integrating oral semaglutide into clinical practice in primary care: for whom, when, and how?
  Stephen A. Brunton, Ofri Mosenzon, Eugene E. Wright Jr
  Postgraduate Medicine.2020; 132(sup2): 48.     CrossRef
• The Safety and Efficacy of Second-Generation Basal Insulin Analogues in Adults with Type 2 Diabetes at Risk of Hypoglycemia and Use in Other Special Populations: A Narrative Review
  Alice Y. Y. Cheng, Jencia Wong, Nick Freemantle, Shamasunder H. Acharya, Elif Ekinci
  Diabetes Therapy.2020; 11(11): 2555.     CrossRef
• Predisposing factors of hypoglycemia in patients with type 2 diabetes mellitus presented with symptomatic hypoglycemia in a tertiary hospital of Bangladesh
  AjitK Paul, A.B.M. Kamrul-Hasan
  Journal of Diabetology.2020; 11(3): 163.     CrossRef
• Development of a hypoglycaemia risk score to identify high‐risk individuals with advanced type 2 diabetes in DEVOTE
  Simon Heller, Ildiko Lingvay, Steven P. Marso, Athena Philis‐Tsimikas, Thomas R. Pieber, Neil R. Poulter, Richard E. Pratley, Elise Hachmann‐Nielsen, Kajsa Kvist, Martin Lange, Alan C. Moses, Marie Trock Andresen, John B. Buse
  Diabetes, Obesity and Metabolism.2020; 22(12): 2248.     CrossRef
• Real-world risk of hypoglycemia-related hospitalization in Japanese patients with type 2 diabetes using SGLT2 inhibitors: a nationwide cohort study
  Takeshi Horii, Yoichi Oikawa, Narumi Kunisada, Akira Shimada, Koichiro Atsuda
  BMJ Open Diabetes Research & Care.2020; 8(2): e001856.     CrossRef
• Common inpatient hypoglycemia phenotypes identified from an automated electronic health record–based prediction model
  Yoonyoung Choi, Ben Staley, Rene Soria-Saucedo, Carl Henriksen, Amy Rosenberg, Almut G Winterstein
  American Journal of Health-System Pharmacy.2019; 76(3): 166.     CrossRef
• Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
  Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
  Cardiovascular Diabetology.2019;[Epub]     CrossRef
• Analysis of the characteristics of patients with diabetes mellitus who attend a tertiary hospital emergency department for a hypoglycemic event
  Jordi Caballero-Corchuelo, Fernando Guerrero-Pérez, Paula García-Sancho de la Jordana, Manuel Pérez-Maraver
  Endocrinología, Diabetes y Nutrición (English ed.).2019; 66(1): 19.     CrossRef
• Management of hypoglycemia in older adults with type 2 diabetes
  Jeffrey Freeman
  Postgraduate Medicine.2019; 131(4): 241.     CrossRef
• Impact of Carbohydrate on Glucose Variability in Patients with Type 1 Diabetes Assessed Through Professional Continuous Glucose Monitoring: A Retrospective Study
  Yi-Hsuan Lin, Yu-Yao Huang, Hsin-Yun Chen, Sheng-Hwu Hsieh, Jui-Hung Sun, Szu-Tah Chen, Chia-Hung Lin
  Diabetes Therapy.2019; 10(6): 2289.     CrossRef
• Association between BMI and risk of severe hypoglycaemia in type 2 diabetes
  J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko
  Diabetes & Metabolism.2019; 45(1): 19.     CrossRef
• Análisis de las características de los pacientes con diabetes mellitus que consultan por hipoglucemia en el servicio de urgencias de un hospital terciario
  Jordi Caballero-Corchuelo, Fernando Guerrero-Pérez, Paula García-Sancho de la Jordana, Manuel Pérez-Maraver
  Endocrinología, Diabetes y Nutrición.2019; 66(1): 19.     CrossRef
• The association between hypoglycemia and hospital use, food insufficiency, and unstable housing conditions: a cross-sectional study among patients with type 2 diabetes in Sudan
  Hyder Osman Mirghani
  BMC Research Notes.2019;[Epub]     CrossRef
• Hypoglycemia after initiating insulin therapy based on the results of structured self-control and monitoring of blood glucose
  A. V. Petrov, L. G. Strongin
  Medical Council.2018; (12): 112.     CrossRef
• Monotherapy in Patients with Type 2 Diabetes Mellitus
  Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
  Diabetes & Metabolism Journal.2017; 41(5): 349.     CrossRef
• Monotherapy in patients with type 2 diabetes mellitus
  Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
  The Korean Journal of Internal Medicine.2017; 32(6): 959.     CrossRef
• Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
  Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
  The Korean Journal of Internal Medicine.2017; 32(6): 947.     CrossRef
• Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association
  Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
  Diabetes & Metabolism Journal.2017; 41(5): 337.     CrossRef

Bariatric surgery, initially intended as a weight-loss procedure, is superior to standard lifestyle intervention and pharmacological therapy for type 2 diabetes in obese individuals. Intensive medical management of hyperglycemia is associated with improved microvascular outcomes. Whether or not the reduction in hyperglycemia observed after bariatric surgery translates to improved microvascular outcomes is yet to be determined. There is substantial heterogeneity in the data relating to the impact of bariatric surgery on diabetic retinopathy (DR), the most common microvascular complication of diabetes. This review aims to collate the recent data on retinal outcomes after bariatric surgery. This comprehensive evaluation revealed that the majority of DR cases remain stable after surgery. However, risk of progression of pre-existing DR and the development of new DR is not eliminated by surgery. Instances of regression of DR are also noted. Potential risk factors for deterioration include severity of DR at the time of surgery and the magnitude of glycated hemoglobin reduction. Concerns also exist over the detrimental effects of postprandial hypoglycemia after surgery. In vivo studies evaluating the chronology of DR development and the impact of bariatric surgery could provide clarity on the situation. For now, however, the effect of bariatric surgery on DR remains inconclusive.

Citations

Citations to this article as recorded by  

• Author response to: remission of diabetes mellitus after bariatric surgery: the putative link with worsening diabetic retinopathy and a need for ongoing postoperative follow-up retinal screening
  Karl Hage, Omar M. Ghanem
  Surgery for Obesity and Related Diseases.2024;[Epub]     CrossRef
• Impact of Bariatric Surgery on Treatment Burden and Progression of Diabetic Retinopathy
  Ariana Allen, Hemal Patel, Sandra S. Stinnett, Jullia A. Rosdahl, Stefanie Schuman
  Journal of VitreoRetinal Diseases.2024;[Epub]     CrossRef
• Role of Systemic Factors in Improving the Prognosis of Diabetic Retinal Disease and Predicting Response to Diabetic Retinopathy Treatment
  Joe Mellor, Anita Jeyam, Joline W.J. Beulens, Sanjeeb Bhandari, Geoffrey Broadhead, Emily Chew, Ward Fickweiler, Amber van der Heijden, Daniel Gordin, Rafael Simó, Janet Snell-Bergeon, Anniina Tynjälä, Helen Colhoun
  Ophthalmology Science.2024; 4(4): 100494.     CrossRef
• The Importance of Glycaemic Control Before Bariatric Surgery: Preventing Microvascular and Metabolic Complications
  Adhithya Sankar, Rajshekhar N. Mudaliar, Rupinder S. Kochhar, Lucinda K. M. Summers, Akheel A. Syed, Waseem Majeed
  Obesity Surgery.2024;[Epub]     CrossRef
• Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes
  Rafael Simó, Josep Franch-Nadal, Bogdan Vlacho, Jordi Real, Ester Amado, Juana Flores, Manel Mata-Cases, Emilio Ortega, Mercedes Rigla, Joan-Anton Vallés, Cristina Hernández, Didac Mauricio
  Diabetes Care.2023; 46(9): 1633.     CrossRef
• Early microvascular complications in type 1 and type 2 diabetes: recent developments and updates
  Kalie L. Tommerdahl, Allison L. B. Shapiro, Edward J. Nehus, Petter Bjornstad
  Pediatric Nephrology.2022; 37(1): 79.     CrossRef
• New Insights into Treating Early and Advanced Stage Diabetic Retinopathy
  Rafael Simó, Cristina Hernández
  International Journal of Molecular Sciences.2022; 23(15): 8513.     CrossRef
• Response to Letter to the Editor Concerning: Adam S. et al. Improvements in Diabetic Neuropathy and Nephropathy After Bariatric Surgery: a Prospective Cohort Study
  Safwaan Adam, Jan Hoong Ho, Akheel A. Syed, Rayaz A. Malik, Handrean Soran
  Obesity Surgery.2022; 32(10): 3460.     CrossRef
• Weight management and multi-morbidity
  Carrie Ashby
  InnovAiT: Education and inspiration for general practice.2021; 14(8): 523.     CrossRef
• The Safety of Pharmacological and Surgical Treatment of Diabetes in Patients with Diabetic Retinopathy—A Review
  Wojciech Matuszewski, Angelika Baranowska-Jurkun, Magdalena Maria Stefanowicz-Rutkowska, Katarzyna Gontarz-Nowak, Ewa Gątarska, Elżbieta Bandurska-Stankiewicz
  Journal of Clinical Medicine.2021; 10(4): 705.     CrossRef
• Safety of Semaglutide
  Mark M. Smits, Daniël H. Van Raalte
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Outcomes of Diabetic Retinopathy Post-Bariatric Surgery in Patients with Type 2 Diabetes Mellitus
  Ana Maria Dascalu, Anca Pantea Stoian, Alina Popa Cherecheanu, Dragos Serban, Daniel Ovidiu Costea, Mihail Silviu Tudosie, Daniela Stana, Denisa Tanasescu, Alexandru Dan Sabau, Gabriel Andrei Gangura, Andreea Cristina Costea, Vanessa Andrada Nicolae, Cata
  Journal of Clinical Medicine.2021; 10(16): 3736.     CrossRef
• Future perspectives in diabesity treatment: Semaglutide, a glucagon‑like peptide 1 receptor agonist (Review)
  Mariana Tilinca, Robert Tiuca, Cristina Niculas, Andreea Varga, Ioan Tilea
  Experimental and Therapeutic Medicine.2021;[Epub]     CrossRef
• Safety of injectable semaglutide for type 2 diabetes
  Rajesh Peter, Steve C. Bain
  Expert Opinion on Drug Safety.2020; 19(7): 785.     CrossRef
• Early worsening of diabetic retinopathy due to intensive glycaemic control
  Shueh Wen Lim, Peter van Wijngaarden, Colin A. Harper, Salmaan H. Al‐Qureshi
  Clinical & Experimental Ophthalmology.2019; 47(2): 265.     CrossRef
• Worsening of diabetic retinopathy with rapid improvement in systemic glucose control: A review
  Stephen C. Bain, Michael A. Klufas, Allen Ho, David R. Matthews
  Diabetes, Obesity and Metabolism.2019; 21(3): 454.     CrossRef
• Diabetische Retinopathie bei Patienten mit Diabetes mellitus
  Olga Simó-Servat, Cristina Hernández, Rafael Simó
  Kompass Ophthalmologie.2019; 5(4): 157.     CrossRef
• Diabetic Retinopathy in the Context of Patients with Diabetes
  Olga Simó-Servat, Cristina Hernández, Rafael Simó
  Ophthalmic Research.2019; 62(4): 211.     CrossRef
• MANAGEMENT OF ENDOCRINE DISEASE: Which metabolic procedure? Comparing outcomes in sleeve gastrectomy and Roux-en Y gastric bypass
  Adrian T Billeter, Javier R de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat P Müller-Stich
  European Journal of Endocrinology.2018; 179(2): R77.     CrossRef
• Aggravation précoce de la rétinopathie diabétique lors de l’optimisation du contrôle glycémique
  S. Feldman-Billard
  Médecine des Maladies Métaboliques.2018; 12(7): 560.     CrossRef
• Semaglutide, reduction in glycated haemoglobin and the risk of diabetic retinopathy
  Tina Vilsbøll, Stephen C. Bain, Lawrence A. Leiter, Ildiko Lingvay, David Matthews, Rafael Simó, Ida Carøe Helmark, Nelun Wijayasinghe, Michael Larsen
  Diabetes, Obesity and Metabolism.2018; 20(4): 889.     CrossRef
• Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Incident Diabetic Retinopathy
  Antonios Douros, Kristian B. Filion, Hui Yin, Oriana Hoi Yu, Mahyar Etminan, Jacob A. Udell, Laurent Azoulay
  Diabetes Care.2018; 41(11): 2330.     CrossRef
• Early worsening of diabetic retinopathy after rapid improvement of blood glucose control in patients with diabetes
  S. Feldman-Billard, É. Larger, P. Massin
  Diabetes & Metabolism.2018; 44(1): 4.     CrossRef
• Excess visceral adiposity is associated with diabetic retinopathy in a multiethnic Asian cohort with longstanding type 2 diabetes
  Angela Moh, Kumari Neelam, Xiao Zhang, Chee Fang Sum, Subramaniam Tavintharan, Keven Ang, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim
  Endocrine Research.2018; 43(3): 186.     CrossRef
• GLP-1R as a Target for the Treatment of Diabetic Retinopathy: Friend or Foe?
  Rafael Simó, Cristina Hernández
  Diabetes.2017; 66(6): 1453.     CrossRef
• The Long-Term Effects of Bariatric Surgery on Type 2 Diabetes Remission, Microvascular and Macrovascular Complications, and Mortality: a Systematic Review and Meta-Analysis
  Binwu Sheng, Khoa Truong, Hugh Spitler, Lu Zhang, Xuetao Tong, Liwei Chen
  Obesity Surgery.2017; 27(10): 2724.     CrossRef
• Bariatric Surgery for Adolescents with Type 2 Diabetes: an Emerging Therapeutic Strategy
  M. A. Stefater, T. H. Inge
  Current Diabetes Reports.2017;[Epub]     CrossRef
• The role of bariatric surgery to treat diabetes: current challenges and perspectives
  Chrysi Koliaki, Stavros Liatis, Carel W. le Roux, Alexander Kokkinos
  BMC Endocrine Disorders.2017;[Epub]     CrossRef

Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agent for the treatment of type 2 diabetes mellitus. They increase endogenous levels of incretin hormones, which stimulate glucose-dependent insulin secretion, decrease glucagon secretion, and contribute to reducing postprandial hyperglycemia. Although DPP-4 inhibitors have similar benefits, they can be differentiated in terms of their chemical structure, pharmacology, efficacy and safety profiles, and clinical considerations. Gemigliptin (brand name: Zemiglo), developed by LG Life Sciences, is a potent, selective, competitive, and long acting DPP-4 inhibitor. Various studies have shown that gemigliptin is an optimized DPP-4 inhibitor in terms of efficacy, safety, and patient compliance for treatment of type 2 diabetes mellitus. In this review, we summarize the characteristics of gemigliptin and discuss its potential benefits in clinical practice.

Citations

Citations to this article as recorded by  

• A Multicenter, Randomized, Open-Label Study to Compare the Effects of Gemigliptin Add-on or Escalation of Metformin Dose on Glycemic Control and Safety in Patients with Inadequately Controlled Type 2 Diabetes Mellitus Treated with Metformin and SGLT-2 Inh
  Hae Jin Kim, Jung Hyun Noh, Min Kyong Moon, Sung Hee Choi, Seung-Hyun Ko, Eun-Jung Rhee, Kyu Yeon Hur, In-Kyung Jeong, Mark Yorek
  Journal of Diabetes Research.2024; 2024: 1.     CrossRef
• Gemigliptin, a potent selective dipeptidyl peptidase 4 inhibitor, protects endothelial progenitor cells by oxidative stress via caspase-3 dependent pathway
  Mijung Lee, Amna Rashid Tariq, Manho Kim
  Biochemistry and Biophysics Reports.2024; 38: 101673.     CrossRef
• Selective targeting of dipeptidyl‐peptidase 4 (DPP‐4) positive senescent chondrocyte ameliorates osteoarthritis progression
  Du Hyun Ro, Gun Hee Cho, Ji Yoon Kim, Seong Ki Min, Ha Ru Yang, Hee Jung Park, Sun Young Wang, You Jung Kim, Myung Chul Lee, Hyun Cheol Bae, Hyuk‐Soo Han
  Aging Cell.2024;[Epub]     CrossRef
• Opportunities and challenges of incretin-based hypoglycemic agents treating type 2 diabetes mellitus from the perspective of physiological disposition
  Yaochen Xie, Qian Zhou, Qiaojun He, Xiaoyi Wang, Jincheng Wang
  Acta Pharmaceutica Sinica B.2023; 13(6): 2383.     CrossRef
• Therapeutic Effects of Switching to Anagliptin from Other DPP-4 Inhibitors in T2DM Patients with Inadequate Glycemic Control: A Non-interventional, Single-Arm, Open-Label, Multicenter Observational Study
  Sang-Yong Kim, Sungrae Kim
  Diabetes Therapy.2023; 14(1): 109.     CrossRef
• Pharmacokinetic and pharmacodynamic interaction of DWP16001, a sodium–glucose cotransporter 2 inhibitor, with gemigliptin and metformin in healthy adults
  Sae Im Jeong, Yun Kim, Jae Jin Nah, Wan Huh, In‐Jin Jang, Jun Gi Hwang, SeungHwan Lee
  British Journal of Clinical Pharmacology.2023; 89(6): 1780.     CrossRef
• 1,2,3‐Triazole analogs with bulky and conformationally rigid substructures: Synthesis and in vitro evaluation as DPP‐4 inhibitors
  Duy‐Viet Vo, Jongkook Lee, Haeil Park
  Bulletin of the Korean Chemical Society.2023; 44(5): 425.     CrossRef
• DPP-4 inhibitors for treating T2DM - hype or hope? an analysis based on the current literature
  Kunika Saini, Smriti Sharma, Yousuf Khan
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• The effect of gemigliptin treatment on immune parameters including regulatory T cells in patients with type 2 diabetes and moderate to very severe chronic renal impairment
  Yanghyeon Kim, Nagyeom Lee, Sujung Heo, Ye Na Kim, Ho Sik Shin, Yeonsoon Jung, Hark Rim
  Medicine.2023; 102(49): e36455.     CrossRef
• Increasing Age Associated with Higher Dipeptidyl Peptidase-4 Inhibition Rate Is a Predictive Factor for Efficacy of Dipeptidyl Peptidase-4 Inhibitors
  Sangmo Hong, Chang Hee Jung, Song Han, Cheol-Young Park
  Diabetes & Metabolism Journal.2022; 46(1): 63.     CrossRef
• Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease?
  Petr Busek, Jonathan S. Duke-Cohan, Aleksi Sedo
  Cancers.2022; 14(9): 2072.     CrossRef
• Divergent Reaction of Activated Pyridines with α,α-Difluorinated gem-Diols: Regioselective Synthesis of gem-Difluorinated Dihydropyridines and Dihydropyridones
  Koushik Patra, Mallu Kesava Reddy, Sumitava Mallik, Mahiuddin Baidya
  Organic Letters.2022; 24(22): 4014.     CrossRef
• Gemigliptin exerts protective effects against doxorubicin-induced hepatotoxicity by inhibiting apoptosis via the regulation of fibroblast growth factor 21 expression
  Kyeong-Min Lee, Yeo Jin Hwang, Gwon-Soo Jung
  Biochemical and Biophysical Research Communications.2022; 626: 135.     CrossRef
• FDA-Approved Trifluoromethyl Group-Containing Drugs: A Review of 20 Years
  Aathira Sujathan Nair, Ashutosh Kumar Singh, Astik Kumar, Sunil Kumar, Sunitha Sukumaran, Vishal Payyalot Koyiparambath, Leena K. Pappachen, T. M. Rangarajan, Hoon Kim, Bijo Mathew
  Processes.2022; 10(10): 2054.     CrossRef
• Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment
  Katherine O. Kopp, Elliot J. Glotfelty, Yazhou Li, Nigel H. Greig
  Pharmacological Research.2022; 186: 106550.     CrossRef
• An evaluation of drug lag for new drugs approved by the Indian regulator relative to the United States, European Union, and Japanese regulatory agencies: A 15-year analysis (2004–2018)
  Mahanjit Konwar, MiteshR Maurya, TusharB Nishandar, UrmilaM Thatte, NithyaJ Gogtay
  Perspectives in Clinical Research.2021; 12(3): 159.     CrossRef
• Pharmacokinetic and Pharmacodynamic Comparison of Two Formulations of a Fixed-Dose Combination of Gemigliptin/Rosuvastatin 50/20 mg: A Randomized, Open-Label, Single-Dose, Two-Way Crossover Study
  Eunsol Yang, Hyounggyoon Yoo, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
  Drug Design, Development and Therapy.2021; Volume 15: 651.     CrossRef
• Efficacy and Safety of the Novel Dipeptidyl Peptidase-4 Inhibitor Gemigliptin in the Management of Type 2 Diabetes: A Meta-Analysis
  Deep Dutta, Anshita Agarwal, Indira Maisnam, Rajiv Singla, Deepak Khandelwal, Meha Sharma
  Endocrinology and Metabolism.2021; 36(2): 374.     CrossRef
• Structure–Activity Relationship Analysis of Cocrystallized Gliptin-like Pyrrolidine, Trifluorophenyl, and Pyrimidine-2,4-Dione Dipeptidyl Peptidase-4 Inhibitors
  Katarina Tomovic, Budimir S. Ilic, Andrija Smelcerovic
  Journal of Medicinal Chemistry.2021; 64(14): 9639.     CrossRef
• A review upon medicinal perspective and designing rationale of DPP-4 inhibitors
  Shubham Kumar, Anu Mittal, Amit Mittal
  Bioorganic & Medicinal Chemistry.2021; 46: 116354.     CrossRef
• Effect of Dipeptidyl Peptidase-4 (DPP-4) Inhibition on Biomarkers of Kidney Injury and Vascular Calcification in Diabetic Kidney Disease: A Randomized Controlled Trial
  Thananda Trakarnvanich, Bancha Satirapoj, Swangjit Suraamornkul, Thanit Chirananthavat, Anoma Sanpatchayapong, Torpong Claimon, Eusebio Chiefari
  Journal of Diabetes Research.2021; 2021: 1.     CrossRef
• Antidiabetic effect of gemigliptin: a systematic review and meta-analysis of randomized controlled trials with Bayesian inference through a quality management system
  Hojin Oh, Hai Duc Nguyen, In Mo Yoon, Byung-Ryong Ahn, Min-Sun Kim
  Scientific Reports.2021;[Epub]     CrossRef
• Pleiotropic Benefits of DPP-4 Inhibitors Beyond Glycemic Control
  Seon Mee Kang, Jeong Hyun Park
  Clinical Medicine Insights: Endocrinology and Diabetes.2021; 14: 117955142110516.     CrossRef
• The vasodilatory effect of gemigliptin via activation of voltage-dependent K+ channels and SERCA pumps in aortic smooth muscle
  Hee Seok Jung, Mi Seon Seo, Jin Ryeol An, Minji Kang, Ryeon Heo, Hongliang Li, Won-Kyo Jung, Il-Whan Choi, Eun-Hee Cho, Hongzoo Park, Young Min Bae, Won Sun Park
  European Journal of Pharmacology.2020; 882: 173243.     CrossRef
• Development and Validation of a Rapid and Sensitive Method for the Simultaneous Estimation of Gemigliptin and Teneligliptin in Bulk and Dosage Forms by Using Liquid Chromatography-tandem Mass Spectrometry
  Amrish Chandra, Ramji Rathod, Faraat Ali, Anuj Prakash, Robin Kumar, Gyanendra Nath Singh
  Current Pharmaceutical Analysis.2020; 16(8): 1104.     CrossRef
• Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury
  Elliot J. Glotfelty, Thomas E. Delgado, Luis B. Tovar-y-Romo, Yu Luo, Barry J. Hoffer, Lars Olson, Tobias E. Karlsson, Mark P. Mattson, Brandon K. Harvey, David Tweedie, Yazhou Li, Nigel H. Greig
  ACS Pharmacology & Translational Science.2019; 2(2): 66.     CrossRef
• Mechanisms and pathways of anti‐inflammatory activity of DPP‐4 inhibitors in cardiovascular and renal protection
  Katarina Tomovic, Jelena Lazarevic, Gordana Kocic, Marina Deljanin‐Ilic, Marko Anderluh, Andrija Smelcerovic
  Medicinal Research Reviews.2019; 39(1): 404.     CrossRef
• Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study
  Yoo-Ri Chung, Kyoung Hwa Ha, Hyeon Chang Kim, Sang Jun Park, Kihwang Lee, Dae Jung Kim
  Diabetes & Metabolism Journal.2019; 43(5): 640.     CrossRef
• Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models
  Dae-Hwan Nam, Jinsook Park, Sun-Hyun Park, Ki-Suk Kim, Eun Bok Baek
  The Korean Journal of Physiology & Pharmacology.2019; 23(5): 329.     CrossRef
• Clinical Use of DPP-4 Inhibitors
  Baptist Gallwitz
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: A 12-Week Interim Report
  Hae Jin Kim, Young Sik Kim, Chang Beom Lee, Moon-Gi Choi, Hyuk-Jae Chang, Soo Kyoung Kim, Jae Myung Yu, Tae Ho Kim, Ji Hyun Lee, Kyu Jeung Ahn, Kyoungmin Kim, Kwan Woo Lee
  Diabetes Therapy.2019; 10(4): 1271.     CrossRef
• Efficacy and Safety of Gemigliptin in Post-Transplant Patients With Type 2 Diabetes Mellitus
  Jaehyun Bae, Youjin Kim, Yongin Cho, Minyoung Lee, Ji-Yeon Lee, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Dong Jin Joo, Kyu Ha Huh, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
  Transplantation Proceedings.2019; 51(10): 3444.     CrossRef
• Protective effects of gemigliptin against type II collagen degradation in human chondrocytes
  Momin Mohetaer, Guoqing Li, Yang Wang, Li Cao
  Biomedicine & Pharmacotherapy.2018; 104: 590.     CrossRef
• Pharmacokinetic Interactions Between Gemigliptin and Metformin, and Potential Differences in the Pharmacokinetic Profile of Gemigliptin Between the Mexican and Korean Populations: A Randomized, Open-label Study in Healthy Mexican Volunteers
  Ignacio Conde-Carmona, Sandra García-Medina, Juan M. Jiménez-Vargas, Alberto Martínez-Muñoz, Sung-Hack Lee
  Clinical Therapeutics.2018; 40(10): 1729.     CrossRef
• Comparative efficacy and safety of gemigliptin versus linagliptin in type 2 diabetes patients with renal impairment: A 40‐week extension of the GUARD randomized study
  Sang Youb Han, Sun Ae Yoon, Byoung Geun Han, Sung Gyun Kim, Young‐Il Jo, Kyung Hwan Jeong, Kook‐Hwan Oh, Hyeong Cheon Park, Sun‐Hee Park, Shin‐Wook Kang, Ki‐Ryang Na, Sun Woo Kang, Nam‐Ho Kim, Younghwan Jang, Bogyeong Kim, Seonghye Shin, Dae Ryong Cha
  Diabetes, Obesity and Metabolism.2018; 20(2): 292.     CrossRef
• Comparative Cardiovascular Risks of Dipeptidyl Peptidase-4 Inhibitors: Analyses of Real-world Data in Korea
  Kyoung Hwa Ha, Bongseong Kim, Hae Sol Shin, Jinhee Lee, Hansol Choi, Hyeon Chang Kim, Dae Jung Kim
  Korean Circulation Journal.2018; 48(5): 395.     CrossRef
• Gemigliptin: Newer promising gliptin for type 2 diabetes mellitus
  Manish Gutch, Abhay Joshi, Sukriti Kumar, Avinash Agarwal, RajendraKumar Pahan, SyedMohd Razi
  Indian Journal of Endocrinology and Metabolism.2017; 21(6): 898.     CrossRef
• Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice
  Seung Hee Choi, Jaechan Leem, In-Kyu Lee
  Mediators of Inflammation.2017; 2017: 1.     CrossRef
• Effects of gemigliptin, a dipeptidyl peptidase‐4 inhibitor, on lipid metabolism and endotoxemia after a high‐fat meal in patients with type 2 diabetes
  Chang Ho Ahn, Eun Ky Kim, Se Hee Min, Tae Jung Oh, Young Min Cho
  Diabetes, Obesity and Metabolism.2017; 19(3): 457.     CrossRef
• Efficacy and safety of gemigliptin, a dipeptidyl peptidase‐4 inhibitor, in patients with type 2 diabetes mellitus inadequately controlled with combination treatment of metformin and sulphonylurea: a 24‐week, multicentre, randomized, double‐blind, placebo‐
  Chang Ho Ahn, Kyung Ah Han, Jae Myung Yu, Joo Young Nam, Kyu Jeung Ahn, Tae Keun Oh, Hyoung Woo Lee, Dae Ho Lee, Jaetaek Kim, Choon Hee Chung, Tae Sun Park, Byung Joon Kim, Seok Won Park, Hyeong Kyu Park, Kwang Jae Lee, Sang‐Wook Kim, Jeong Hyun Park, Kwa
  Diabetes, Obesity and Metabolism.2017; 19(5): 635.     CrossRef

The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus (T2DM) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size (ES) for the effect of exercise on insulin sensitivity (ES, –0.588; 95% confidence interval [CI], –0.816 to –0.359; P<0.001). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise (ES, –0.702; 95% CI, –1.392 to –0.012; P=0.046); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session (ES, –0.890; 95% CI, –1.675 to –0.105; P=0.026). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session.

Citations

Citations to this article as recorded by  

• Exercise Increasing Health-Related Quality of Life in Type 2 Diabetics: A Meta-Analysis
  Sohrab Amiri, Mina Fathi-Ashtiani
  Physical & Occupational Therapy In Geriatrics.2023; 41(3): 383.     CrossRef
• Early intervention and intensive management of patients with diabetes, cardiorenal, and metabolic diseases
  Yehuda Handelsman, Javed Butler, George L. Bakris, Ralph A. DeFronzo, Gregg C. Fonarow, Jennifer B. Green, George Grunberger, James L. Januzzi, Samuel Klein, Pamela R. Kushner, Darren K. McGuire, Erin D. Michos, Javier Morales, Richard E. Pratley, Matthew
  Journal of Diabetes and its Complications.2023; 37(2): 108389.     CrossRef
• Frequency, intensity and duration of muscle strengthening activity and associations with mental health
  Stephen Shannon, Mark Shevlin, Noel Brick, Gavin Breslin
  Journal of Affective Disorders.2023; 325: 41.     CrossRef
• The effects of swimming exercise and detraining on hemorheological parameters and oxidative stress in rats with metabolic syndrome
  Busra Emik-Ozdemir, Melek Tunc-Ata, Yasin Ozdemir, Ozgen Kilic-Erkek, Hande Senol, Vural Kucukatay, Melek Bor-Kucukatay
  Nutrition Clinique et Métabolisme.2023; 37(2): 94.     CrossRef
• Exercise and heart disease
  Nick Gardner, Christopher Beck
  InnovAiT: Education and inspiration for general practice.2023; 16(7): 337.     CrossRef
• Dietary weight loss-induced improvements in metabolic function are enhanced by exercise in people with obesity and prediabetes
  Joseph W. Beals, Brandon D. Kayser, Gordon I. Smith, George G. Schweitzer, Kyleigh Kirbach, Monica L. Kearney, Jun Yoshino, Gibraan Rahman, Rob Knight, Bruce W. Patterson, Samuel Klein
  Nature Metabolism.2023; 5(7): 1221.     CrossRef
• Investigating the Effect of Aerobic and Resistance Training on Insulin Resistance and Some Cardiovascular Disease Risk Factors in Type 2 Diabetes Mellitus Patients: A Systematic Review
  Peyman Kaikhosro Doulatyari, Mehran Ghahramani, Kosar Mozaffari
  Journal of Clinical Research in Paramedical Sciences.2023;[Epub]     CrossRef
• Recommendations from Diabetes UK's 2022 diabetes and physical activity workshop
  Anna Morris, Chris Bright, Matthew Cocks, Neil Gibson, Louise Goff, Colin Greaves, Simon Griffin, Ben Jane, Florence Kinnafick, Paul Robb, Michelle Roberts, David Salman, John Saxton, Adrian Taylor, Daniel West, Thomas Yates, Rob C. Andrews, Jason M. R. G
  Diabetic Medicine.2023;[Epub]     CrossRef
• Impact of Physical Exercise on Platelets: Focus on Its Effects in Metabolic Chronic Diseases
  Cristina Barale, Elena Melchionda, Giulia Tempesta, Alessandro Morotti, Isabella Russo
  Antioxidants.2023; 12(8): 1609.     CrossRef
• Exercise in the Management of Metabolic-Associated Fatty Liver Disease (MAFLD) in Adults: A Position Statement from Exercise and Sport Science Australia
  Shelley E. Keating, Angelo Sabag, Kate Hallsworth, Ingrid J. Hickman, Graeme A. Macdonald, Jonathan G. Stine, Jacob George, Nathan A. Johnson
  Sports Medicine.2023; 53(12): 2347.     CrossRef
• Effects of Using the Bioelectrical Impedance Method in Nutritional Guidance for Diabetes
  Naoko Nishizaka, Shinichirou Shiozawa, Kohzo Nakayama, Kenichi Hirose
  The Japanese Journal of Nutrition and Dietetics.2023; 81(5): 228.     CrossRef
• Effects of moderate exercise versus light exercise on fasting blood glucose in obese patients with type 2 diabetes mellitus
  Manal Kamel Youssef
  Physiotherapy Quarterly.2023; 31(3): 101.     CrossRef
• The Comparison of High-Intensity Interval Training and Moderate-intensity Continuous Training on Inflammatory and Metabolic Variables in Type 2 Diabetes: Study Protocol for A Pilot Randomized Controlled Trial
  Sahar Alizadeh, Nahid Mahdieh, Morteza Lotfi Khachak, Mohsen Avandi, Mehdi Hedayati, Camelia Rambod, Hooman Bakhshandeh
  Research in Cardiovascular Medicine.2023; 12(4): 117.     CrossRef
• Acute exercise improves glucose effectiveness but not insulin sensitivity in paraplegia
  Gary J. Farkas, Ann M. Swartz, Ashraf S. Gorgey, Arthur S. Berg, David R. Gater
  Disability and Rehabilitation.2022; 44(17): 4656.     CrossRef
• Cultural validation and language translation of the scientific SCI exercise guidelines for use in Indonesia, Japan, Korea, and Thailand
  Yukio Mikami, Damayanti Tinduh, KunHo Lee, Chayaporn Chotiyarnwong, Jan W. van der Scheer, Kyung Su Jung, Hiroshi Shinohara, Inggar Narasinta, Seung Hyun Yoon, Napatpaphan Kanjanapanang, Takafumi Sakai, Martha K. Kusumawardhani, Jinho Park, Pannika Prachg
  The Journal of Spinal Cord Medicine.2022; 45(6): 821.     CrossRef
• Effect of Application of Treadmill Training on Metabolic Control and Vitamin D Level in Saudi Patients with Type 2 Diabetes Mellitus
  Ahmad El Askary, Alaa Shafie, Mazen Almehmadi, Hatem H. Allam, Lamiaa K. Elsayyad, Asmaa F. Hassan, Bader B. Althobaiti, Mohamed Mansour Khalifa, Tamer Saber, Aisha H. Alharthi, Amal F. Gharib, Deepika Koundal
  Computational and Mathematical Methods in Medicine.2022; 2022: 1.     CrossRef
• Skeletal Muscle Hyperemia: A Potential Bridge Between Post-exercise Hypotension and Glucose Regulation
  Thomas K. Pellinger, Chi-An W. Emhoff
  Frontiers in Physiology.2022;[Epub]     CrossRef
• Exercise, Physical Activity, and Cardiometabolic Health
  Matthew J. Belanger, Prashant Rao, Jeremy M. Robbins
  Cardiology in Review.2022; 30(3): 134.     CrossRef
• Modeling the effects of physical activity, education, health, and subjective wealth on happiness based on Indonesian national survey data
  Bhina Patria
  BMC Public Health.2022;[Epub]     CrossRef
• Effects of time-restricted feeding with different feeding windows on metabolic health: A systematic review of human studies
  Zhibo Xie, Zhangyuting He, Yuqian Ye, Yilei Mao
  Nutrition.2022; 102: 111764.     CrossRef
• Effect of Exercise Instructions With Ambulatory Accelerometer in Japanese Patients With Type 2 Diabetes: a Randomized Control Trial
  Jin Matsushita, Hiroshi Okada, Yuki Okada, Takashi Sekiyama, Hideto Iida, Atsushi Shindo, Hiroaki Murata, Michiaki Fukui
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Resistance Exercise and Cardiovascular Disease in Diabetes Mellitus
  Jin-Hwan Yoon
  Journal of Obesity & Metabolic Syndrome.2022; 31(2): 97.     CrossRef
• Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
  Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
  Pharmacological Research.2022; 182: 106358.     CrossRef
• Endurance Training Improves GLP-1 Sensitivity and Glucose Tolerance in Overweight Women
  Thorbjörn Åkerström, Malene N Stolpe, Renate Widmer, Thomas F Dejgaard, Jens M Højberg, Kirsten Møller, Jakob S Hansen, Beckey Trinh, Jens J Holst, Carsten Thomsen, Bente K Pedersen, Helga Ellingsgaard
  Journal of the Endocrine Society.2022;[Epub]     CrossRef
• Assessing related factors to fasting blood sugar and glycosylated hemoglobin in patients with type 2 diabetes simultaneously by a multivariate longitudinal marginal model
  Samaneh Hosseinzadeh, Zahra Khatirnamani, Enayatollah Bakhshi, Alireza Heidari, Arash Naghipour
  Scientific Reports.2022;[Epub]     CrossRef
• Adherence to aerobic and muscle-strengthening components of the physical activity guidelines and mental health
  Stephen Shannon, Angela Carlin, Catherine Woods, Alan M Nevill, Niamh Murphy, Marie H Murphy
  Health Promotion International.2022;[Epub]     CrossRef
• Physical activity interventions for glycaemic control in African adults – A systematic review and meta-analysis
  Chythra R. Rao, Baskaran Chandrasekaran, N. Ravishankar, Elizeus Rutebemberwa, David Okello
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2022; 16(12): 102663.     CrossRef
• The effect of acute aerobic exercise on central arterial stiffness, wave reflections, and hemodynamics in adults with diabetes: A randomized cross-over design
  Kimberley L. Way, Angela S. Lee, Stephen M. Twigg, Nathan A. Johnson
  Journal of Sport and Health Science.2021; 10(4): 499.     CrossRef
• Resistance training attenuates circulating FGF‐21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: A randomised controlled clinical trial
  Fatemeh Shabkhiz, Mousa Khalafi, Sara Rosenkranz, Pouran Karimi, Kamilia Moghadami
  European Journal of Sport Science.2021; 21(4): 636.     CrossRef
• The interaction between metformin and physical activity on postprandial glucose and glucose kinetics: a randomised, clinical trial
  Nanna S. Pilmark, Mark Lyngbæk, Laura Oberholzer, Ida Elkjær, Christina Petersen-Bønding, Katja Kofoed, Christoph Siebenmann, Katja Kellenberger, Gerrit van Hall, Julie Abildgaard, Helga Ellingsgaard, Carsten Lauridsen, Mathias Ried-Larsen, Bente K. Peder
  Diabetologia.2021; 64(2): 397.     CrossRef
• Effects of structured Aerobic Exercise on selected clinical profiles of patients with type 2 diabetes mellitus: A systematic review with meta-analysis
  NmachukwuIfeoma Ekechukwu, StellaUdumma Anwara, UkamakaGloria Mgbeojedo, OliveU Chijioke, OkechukwuSteven Onwukwe, UchechukwuAnthonia Ezugwu, EchezonaNelson Dominic Ekechukwu, IjeomaL Okoronkwo
  International Journal of Medicine and Health Development.2021; 26(1): 17.     CrossRef
• Impact of acute exercise on immediate and following early post-exercise FGF-21 concentration in adults: systematic review and meta-analysis
  Mousa Khalafi, Karim Azali Alamdari, Michael E. Symonds, Hadi Nobari, Jorge Carlos-Vivas
  Hormones.2021; 20(1): 23.     CrossRef
• Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society
  Eiichi Araki, Atsushi Tanaka, Nobuya Inagaki, Hiroshi Ito, Kohjiro Ueki, Toyoaki Murohara, Kenjiro Imai, Masataka Sata, Takehiro Sugiyama, Hideki Ishii, Shunsuke Yamane, Takashi Kadowaki, Issei Komuro, Koichi Node
  Diabetology International.2021; 12(1): 1.     CrossRef
• In silico study to quantify the effect of exercise on surface GLUT4 translocation in diabetes management
  Darshna M. Joshi, Jignesh Patel, Hardik Bhatt
  Network Modeling Analysis in Health Informatics and Bioinformatics.2021;[Epub]     CrossRef
• Stair climbing–descending exercise following meals improves 24-hour glucose excursions in people with type 2 diabetes
  Hiroto Honda, Makoto Igaki, Motoaki Komatsu, Shin-ichiro Tanaka, Tetsuo Takaishi, Tatsuya Hayashi
  The Journal of Physical Fitness and Sports Medicine.2021; 10(1): 51.     CrossRef
• Glycemic Control of Diabetes Mellitus Patients in Referral Hospitals of Amhara Region, Ethiopia: A Cross-Sectional Study
  Berhanu Elfu Feleke, Teferi Elfu Feleke, Melkamu Beyene Kassahun, Wondemu Gebrekirose Adane, Netsanet Fentahun, Abel Girma, Alamirew Alebachew, Eyaya Misgan, Hanna Demelash Desyibelew, Mulat Tirfie Bayih, Omer Seid, Daniel Diaz
  BioMed Research International.2021; 2021: 1.     CrossRef
• Influences of Recreational Tennis-Playing Exercise Time on Cardiometabolic Health Parameters in Healthy Elderly: The ExAMIN AGE Study
  Hsiao-Han Chao, Yi-Hung Liao, Chun-Chung Chou
  International Journal of Environmental Research and Public Health.2021; 18(3): 1255.     CrossRef
• Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise
  Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma, Raffaella Mastrocola
  Journal of Diabetes Research.2021; 2021: 1.     CrossRef
• Metabolically healthy obese vs. Metabolic syndrome – The crosslink between nutritional exposure to bisphenols and physical exercise
  Jessica Jones, Paul Reneau, Julia Matzenbacher dos Santos
  Medical Hypotheses.2021; 149: 110542.     CrossRef
• The effects of different doses of exercise on pancreatic β-cell function in patients with newly diagnosed type 2 diabetes: study protocol for and rationale behind the “DOSE-EX” multi-arm parallel-group randomised clinical trial
  Mark P. P. Lyngbaek, Grit E. Legaard, Sebastian L. Bennetsen, Camilla S. Feineis, Villads Rasmussen, Nana Moegelberg, Cecilie F. Brinkløv, Anette B. Nielsen, Katja S. Kofoed, Carsten A. Lauridsen, Caroline Ewertsen, Henrik E. Poulsen, Robin Christensen, G
  Trials.2021;[Epub]     CrossRef
• Skeletal Muscle–Adipose Tissue–Tumor Axis: Molecular Mechanisms Linking Exercise Training in Prostate Cancer
  Sílvia Rocha-Rodrigues, Andreia Matos, José Afonso, Miguel Mendes-Ferreira, Eduardo Abade, Eduardo Teixeira, Bruno Silva, Eugenia Murawska-Ciałowicz, Maria José Oliveira, Ricardo Ribeiro
  International Journal of Molecular Sciences.2021; 22(9): 4469.     CrossRef
• Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials
  Edoardo Mannucci, Allegra Bonifazi, Matteo Monami
  Nutrition, Metabolism and Cardiovascular Diseases.2021; 31(7): 1985.     CrossRef
• Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat—A systematic review and meta‐analysis
  Francesca Battista, Andrea Ermolao, Marleen A. van Baak, Kristine Beaulieu, John E. Blundell, Luca Busetto, Eliana V. Carraça, Jorge Encantado, Dror Dicker, Nathalie Farpour‐Lambert, Adriyan Pramono, Alice Bellicha, Jean‐Michel Oppert
  Obesity Reviews.2021;[Epub]     CrossRef
• The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial
  Taiki Sugimoto, Atsushi Araki, Hiroki Fujita, Keiko Honda, Nobuya Inagaki, Takeshi Ishida, Junichi Kato, Minoru Kishi, Kazuki Kobayashi, Kunichi Kouyama, Hisashi Noma, Mitsuru Ohishi, Noriko Satoh-Asahara, Hiroyuki Shimada, Kazuhiro Sugimoto, Susumu Suzuk
  Frontiers in Aging Neuroscience.2021;[Epub]     CrossRef
• Interactive effects of acute exercise and carbohydrate-energy replacement on insulin sensitivity in healthy adults
  Drusus A. Johnson-Bonson, Benjamin J. Narang, Russell G. Davies, Aaron Hengist, Harry A. Smith, Jonathan D. Watkins, Harry Taylor, Jean-Philippe Walhin, Javier T. Gonzalez, James A. Betts
  Applied Physiology, Nutrition, and Metabolism.2021; 46(10): 1207.     CrossRef
• The importance of physical activity in management of type 2 diabetes and COVID-19
  Samuel Seidu, Kamlesh Khunti, Tom Yates, Abdullah Almaqhawi, M.J. Davies, Jack Sargeant
  Therapeutic Advances in Endocrinology and Metabolism.2021; 12: 204201882110546.     CrossRef
• Appraisal of Triglyceride-Related Markers as Early Predictors of Metabolic Outcomes in the PREVIEW Lifestyle Intervention: A Controlled Post-hoc Trial
  Santiago Navas-Carretero, Rodrigo San-Cristobal, Pia Siig Vestentoft, Jennie C. Brand-Miller, Elli Jalo, Margriet Westerterp-Plantenga, Elizabeth J. Simpson, Teodora Handjieva-Darlenska, Gareth Stratton, Maija Huttunen-Lenz, Tony Lam, Roslyn Muirhead, Sal
  Frontiers in Nutrition.2021;[Epub]     CrossRef
• Insulin Resistance Remission Following Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy in Chinese Type 2 Diabetes Mellitus Patients With a Body Mass Index of 27.5–32.5 kg/m2
  Ping Luo, Yaoquan Cao, Pengzhou Li, Guohui Wang, Zhi Song, Weizheng Li, Zhihong Su, Hui Zhou, Xianhao Yi, Zhibing Fu, Xulong Sun, Haibo Tang, Beibei Cui, Qianqian Yu, Liyong Zhu, Shaihong Zhu
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Effects of Metronidazole as an Adjunct to Non-Surgical Periodontal Therapy on Insulin Resistance in Type 2 Diabetics
  Ambrina Qureshi, Zeba Haque, Hina Qureshi, Waqas Ahmed Farooqui
  Antibiotics.2021; 10(11): 1400.     CrossRef
• Exercise Training Combined with Calanus Oil Supplementation Improves the Central Cardiodynamic Function in Older Women
  Marek Štěpán, Klára Daďová, Miloš Matouš, Eva Krauzová, Lenka Sontáková, Michal Koc, Terje Larsen, Ondrej Kuda, Vladimír Štich, Lenka Rossmeislová, Michaela Šiklová
  Nutrients.2021; 14(1): 149.     CrossRef
• Effectiveness of combined exercise in people with type 2 diabetes and concurrent overweight/obesity: a systematic review and meta-analysis
  Xiaoyan Zhao, Qianyu He, Yongmei Zeng, Li Cheng
  BMJ Open.2021; 11(10): e046252.     CrossRef
• Type 2 Diabetes Remission and Lifestyle Medicine: A Position Statement From the American College of Lifestyle Medicine
  John Kelly, Micaela Karlsen, Gregory Steinke
  American Journal of Lifestyle Medicine.2020; 14(4): 406.     CrossRef
• Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
  Yun Kyung Jeon, Sang Soo Kim, Jong Ho Kim, Hyun Jeong Kim, Hyun Jun Kim, Jang Jun Park, Yuen Suk Cho, So Hee Joung, Ji Ryang Kim, Bo Hyun Kim, Sang Heon Song, In Joo Kim, Yong Ki Kim, Young-Bum Kim
  Diabetes & Metabolism Journal.2020; 44(1): 103.     CrossRef
• The effect of low-volume high-intensity interval training on cardiovascular health outcomes in type 2 diabetes: A randomised controlled trial
  Kimberley L. Way, Angelo Sabag, Rachelle N. Sultana, Michael K. Baker, Shelley E. Keating, Sean Lanting, James Gerofi, Vivienne H. Chuter, Ian D. Caterson, Stephen M. Twigg, Nathan A. Johnson
  International Journal of Cardiology.2020; 320: 148.     CrossRef
• Effects of IL-6 Signaling Pathway Inhibition on Weight and BMI: A Systematic Review and Meta-Analysis
  Olivia Patsalos, Bethan Dalton, Hubertus Himmerich
  International Journal of Molecular Sciences.2020; 21(17): 6290.     CrossRef
• Non-Dietary Factors Associated with Glycemic Status among Adults Diagnosed with Type 2 Diabetes Mellitus in Malawi
  Getrude Mphwanthe, Dave Weatherspoon, Alexander Kalimbira, Lorraine Weatherspoon
  Social Work in Public Health.2020; 35(6): 380.     CrossRef
• The impact of high‐intensity interval training on inflammatory markers in metabolic disorders: A meta‐analysis
  Mousa Khalafi, Michael E. Symonds
  Scandinavian Journal of Medicine & Science in Sports.2020; 30(11): 2020.     CrossRef
• Effectiveness of martial arts exercise on anthropometric and body composition parameters of overweight and obese subjects: a systematic review and meta-analysis
  Fabricio de Souza, Felipe Nunes Lanzendorf, Márcia Mendonça Marcos de Souza, Fabiana Schuelter-Trevisol, Daisson José Trevisol
  BMC Public Health.2020;[Epub]     CrossRef
• Optimal Human Functioning Requires Exercise Across the Lifespan: Mobility in a 1g Environment Is Intrinsic to the Integrity of Multiple Biological Systems
  David A. Hart, Ronald F. Zernicke
  Frontiers in Physiology.2020;[Epub]     CrossRef
• Managing NAFLD in Type 2 Diabetes: The Effect of Lifestyle Interventions, a Narrative Review
  Siôn A. Parry, Leanne Hodson
  Advances in Therapy.2020; 37(4): 1381.     CrossRef
• Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle
  Sung Sup Park, Young-Kyo Seo
  International Journal of Molecular Sciences.2020; 21(6): 1949.     CrossRef
• The Effect of Resistance Exercise Intensity on Acute Hyperglycemia in Young Adult Males
  Evan E. Schick, Luis E. Segura, Shayán Emamjomeh, Joshua A. Cotter
  Sports.2020; 8(9): 121.     CrossRef
• Drop-out ratio between moderate to high-intensity physical exercise treatment by patients with, or at risk of, type 2 diabetes mellitus: A systematic review and meta-analysis
  Guillem Jabardo-Camprubí, Rafel Donat-Roca, Mercè Sitjà-Rabert, Raimon Milà-Villarroel, Judit Bort-Roig
  Physiology & Behavior.2020; 215: 112786.     CrossRef
• Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial
  Mette Y. Johansen, Kristian Karstoft, Christopher S. MacDonald, Katrine B. Hansen, Helga Ellingsgaard, Bolette Hartmann, Nicolai J. Wewer Albrechtsen, Allan A. Vaag, Jens J. Holst, Bente K. Pedersen, Mathias Ried-Larsen
  Diabetologia.2020; 63(11): 2410.     CrossRef
• The effect of BPA exposure on insulin resistance and type 2 diabetes – The impact of muscle contraction
  Madison Wade, Virginia Delawder, Paul Reneau, Julia M. dos Santos
  Medical Hypotheses.2020; 140: 109675.     CrossRef
• Dynamic glucose disposal is driven by reduced endogenous glucose production in response to voluntary wheel running: a stable isotope approach
  Timothy D. Allerton, Greg M. Kowalski, Hardy Hang, Jacqueline Stephens
  American Journal of Physiology-Endocrinology and Metabolism.2020; 319(1): E2.     CrossRef

• Antidiabetic Effects of Physical Activity: How It Helps to Control Type 2 Diabetes

  
  Addisu Dabi Wake
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2020; Volume 13: 2909.     CrossRef
• The effect of endurance training with crocin consumption on the levels of MFN2 and DRP1 gene expression and glucose and insulin indices in the muscle tissue of diabetic rats
  Abdolnabi Peyravi, Nasrin Yazdanpanahi, Hashem Nayeri, Seyyed Ali Hosseini
  Journal of Food Biochemistry.2020;[Epub]     CrossRef
• Evidence for Training-Induced Changes in miRNA Levels in the Skeletal Muscle of Patients With Type 2 Diabetes Mellitus
  Sarah Simaitis, Benedikt Schulte-Körne, Thorsten Schiffer, Wilhelm Bloch, Hans-Georg Predel, Klara Brixius, Christian Brinkmann
  Frontiers in Physiology.2020;[Epub]     CrossRef
• Metabolic diseases affect male reproduction and induce signatures in gametes that may compromise the offspring health
  Sara C Pereira, Luís Crisóstomo, Mário Sousa, Pedro F Oliveira, Marco G Alves, Caroline Burson
  Environmental Epigenetics.2020;[Epub]     CrossRef
• Different mr-proANP-release in High Volume High Intensity Interval Exercise and Continuous Exercise Regimens with Matched Mean Intensity: A Cross-over Design Study
  Julian Eigendorf
  Exercise Medicine.2020; 4: 5.     CrossRef
• Diagnosis, Prevention, and Treatment of Cardiovascular Diseases in People With Type 2 Diabetes and Prediabetes　― A Consensus Statement Jointly From the Japanese Circulation Society and the Japan Diabetes Society ―
  Eiichi Araki, Atsushi Tanaka, Nobuya Inagaki, Hiroshi Ito, Kohjiro Ueki, Toyoaki Murohara, Kenjiro Imai, Masataka Sata, Takehiro Sugiyama, Hideki Ishii, Shunsuke Yamane, Takashi Kadowaki, Issei Komuro, Koichi Node
  Circulation Journal.2020; 85(1): 82.     CrossRef
• Aerobic training reduces immune cell recruitment and cytokine levels in adipose tissue in obese mice
  Débora Romualdo Lacerda, Michele Macedo Moraes, Albená Nunes-Silva, Kátia Anunciação Costa, Débora Fernandes Rodrigues, Josiana Lopes Sabino, Letícia Maria de Souza Cordeiro, Vanessa Pinho, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares,
  Applied Physiology, Nutrition, and Metabolism.2019; 44(5): 512.     CrossRef
• Pharmacologic and Exercise Considerations in Older Adults With Diabetes
  Susan L. Wenker, Denise L. Walbrandt Pigarelli
  Topics in Geriatric Rehabilitation.2019; 35(1): 31.     CrossRef
• Human skeletal muscle macrophages increase following cycle training and are associated with adaptations that may facilitate growth
  R. Grace Walton, Kate Kosmac, Jyothi Mula, Christopher S. Fry, Bailey D. Peck, Jason S. Groshong, Brian S. Finlin, Beibei Zhu, Philip A. Kern, Charlotte A. Peterson
  Scientific Reports.2019;[Epub]     CrossRef
• An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods
  Jessica Turton, Grant D. Brinkworth, Rowena Field, Helen Parker, Kieron Rooney
  Diabetes, Obesity and Metabolism.2019; 21(11): 2513.     CrossRef
• Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and dietary-related adjuncts on antidepressant treatment response: protocol for a systematic review and meta-analysis
  Olaitan J. Jeremiah, Gráinne Cousins, Finbarr P. Leacy, Brian P. Kirby, Benedict K. Ryan
  Systematic Reviews.2019;[Epub]     CrossRef
• Association Between Exercise and Treatment with Liraglutide in Obese Rats by Cafeteria Diet
  Daiane Didek, Maiara Mikuska Cordeiro, João Lucas de Paula Xavier, Paulo Roberto Ribeiro, Thiago Rentz, Gilson Cesar Nobre Franco, Carla Cristine Kanunfre, Henriette Rosa de Oliveira Emilio, Dionízia Xavier Scomparin
  Brazilian Archives of Biology and Technology.2019;[Epub]     CrossRef
• Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway
  Shi-Qiang Wang, Dan Li, Yang Yuan
  The Journal of Physiological Sciences.2019; 69(6): 861.     CrossRef
• Low-Intensity Running and High-Intensity Swimming Exercises Differentially Improve Energy Metabolism in Mice With Mild Spinal Muscular Atrophy
  Léo Houdebine, Domenico D’Amico, Jean Bastin, Farah Chali, Céline Desseille, Valentin Rumeau, Judy Soukkari, Carole Oudot, Thaïs Rouquet, Bruno Bariohay, Julien Roux, Delphine Sapaly, Laure Weill, Philippe Lopes, Fatima Djouadi, Cynthia Bezier, Frédéric C
  Frontiers in Physiology.2019;[Epub]     CrossRef
• Moderate-to-Vigorous-Intensity Physical Activity Observed in People With Diabetes-Related Foot Ulcers Over a One-Week Period
  Maggie Lee, Jaap J. van Netten, Helen Sheahan, Peter A. Lazzarini
  Journal of Diabetes Science and Technology.2019; 13(5): 827.     CrossRef
• The effect of high Intensity interval training versus moderate intensity continuous training on arterial stiffness and 24 h blood pressure responses: A systematic review and meta-analysis
  Kimberley L. Way, Rachelle N. Sultana, Angelo Sabag, Michael K. Baker, Nathan A. Johnson
  Journal of Science and Medicine in Sport.2019; 22(4): 385.     CrossRef
• PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training
  Martin Bæk Blond, Theresia Maria Schnurr, Mads Rosenkilde, Jonas Salling Quist, Anne Sofie Gram, Michala Holm Reichkendler, Pernille Landrock Auerbach, Pernille Nordby, Lene Theil Skovgaard, Rasmus Ribel-Madsen, Johanne Marie Justesen, Tuomas Oskari Kilpe
  Physiological Genomics.2019; 51(6): 254.     CrossRef
• Physical Activity and Sports—Real Health Benefits: A Review with Insight into the Public Health of Sweden
  Christer Malm, Johan Jakobsson, Andreas Isaksson
  Sports.2019; 7(5): 127.     CrossRef
• Exercise and Inflammation
  Llion Roberts, Katsuhiko Suzuki
  Antioxidants.2019; 8(6): 155.     CrossRef
• Effects of a 12-week moderate-intensity exercise training on blood glucose response in patients with type 2 diabetes
  Shang-Lin Chiang, Margaret McLean Heitkemper, Yi-Jen Hung, Wen-Chii Tzeng, Meei-Shyuan Lee, Chia-Huei Lin
  Medicine.2019; 98(36): e16860.     CrossRef
• A influência do exercício físico na captação de glicose independente de insulina
  Leonardo Soares de Albuquerque Barros, Camila da Cunha Nunes
  HU Revista.2019; 45(1): 59.     CrossRef
• A pilot randomized controlled trial of 6-week combined exercise program on fasting insulin and fitness levels in individuals with spinal cord injury
  Dong-Il Kim, J. Andrew Taylor, Can Ozan Tan, Hyuna Park, Ji Young Kim, Sang-Yong Park, Kyong-Mee Chung, Young-Hee Lee, Bum-Suk Lee, Justin Y. Jeon
  European Spine Journal.2019; 28(5): 1082.     CrossRef
• Association between physical activity and diabetic complications among Bangladeshi type 2 diabetic patients
  Mohammad Sadaat Bukht, Kazi Rumana Ahmed, Sahadat Hossain, Parisha Masud, Shuhana Sultana, Rasheda Khanam
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 806.     CrossRef
• Exercise and insulin resistance in type 2 diabetes mellitus: A systematic review and meta-analysis
  A. Sampath Kumar, Arun G. Maiya, B.A. Shastry, K. Vaishali, N. Ravishankar, Animesh Hazari, Shubha Gundmi, Radhika Jadhav
  Annals of Physical and Rehabilitation Medicine.2019; 62(2): 98.     CrossRef
• Ultra-performance liquid chromatography-mass spectrometry-based metabolomics reveals Huangqiliuyi decoction attenuates abnormal metabolism as a novel therapeutic opportunity for type 2 diabetes
  Jiao Xu, Zhe-hui Jiang, Xiu-bo Liu, Yan Ma, Wei Ma, Ling Ma
  RSC Advances.2019; 9(68): 39858.     CrossRef
• Importance of the Madras Diabetes Research Foundation-Indian Diabetes Risk Score (MDRF-IDRS) for mass screening of type 2 diabetes and its complications at primary health care centers of North India
  Mohammad Mustufa Khan, Gyanendra Kumar Sonkar, Sangeeta Singh, Satyendra Kumar Sonkar
  International Journal of Diabetes in Developing Countries.2019; 39(3): 419.     CrossRef
• Sugar in mind: Untangling a sweet and sour relationship beyond type 2 diabetes
  Nicolas Cherbuin, Erin I. Walsh
  Frontiers in Neuroendocrinology.2019; 54: 100769.     CrossRef
• Aerobic exercise training may improve nerve function in type 2 diabetes and pre‐diabetes: A systematic review
  Yu Gu, Sarah M. Dennis, Matthew C. Kiernan, Alison R. Harmer
  Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
• Air Pollution Has a Significant Negative Impact on Intentional Efforts to Lose Weight: A Global Scale Analysis
  Morena Ustulin, So Young Park, Sang Ouk Chin, Suk Chon, Jeong-taek Woo, Sang Youl Rhee
  Diabetes & Metabolism Journal.2018; 42(4): 320.     CrossRef
• Non-pharmacological Treatment Options in the Management of Diabetes Mellitus
  Arkiath V Raveendran
  European Endocrinology.2018; 14(2): 31.     CrossRef
• Adaptation of Skeletal Muscles to Contractile Activity of Varying Duration and Intensity: The Role of PGC-1α
  D. V. Popov
  Biochemistry (Moscow).2018; 83(6): 613.     CrossRef
• High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: A meta-analysis
  Angélica Trevisan De Nardi, Tainara Tolves, Thatiane Larissa Lenzi, Luis Ulisses Signori, Antônio Marcos Vargas da Silva
  Diabetes Research and Clinical Practice.2018; 137: 149.     CrossRef
• Obstructive Sleep Apnea Syndrome, Objectively Measured Physical Activity and Exercise Training Interventions: A Systematic Review and Meta-Analysis
  Monique Mendelson, Sébastien Bailly, Mathieu Marillier, Patrice Flore, Jean Christian Borel, Isabelle Vivodtzev, Stéphane Doutreleau, Samuel Verges, Renaud Tamisier, Jean-Louis Pépin
  Frontiers in Neurology.2018;[Epub]     CrossRef
• Affective Adaptation to Repeated SIT and MICT Protocols in Insulin-Resistant Subjects
  TIINA SAANIJOKI, LAURI NUMMENMAA, MIKKO KOIVUMÄKI, ELIISA LÖYTTYNIEMI, KARI K. KALLIOKOSKI, JARNA C. HANNUKAINEN
  Medicine & Science in Sports & Exercise.2018; 50(1): 18.     CrossRef
• Aerobic training improves platelet function in type 2 diabetic patients: role of microRNA-130a and GPIIb
  Atousa Akbarinia, Mehdi Kargarfard, Mahmood Naderi
  Acta Diabetologica.2018; 55(9): 893.     CrossRef
• Physical activity: the key to cardiometabolic risk reduction in obstructive sleep apnoea
  Monique Mendelson, Patrice Flore
  European Respiratory Journal.2018; 52(4): 1801775.     CrossRef
• Potential effect of exercise in ameliorating insulin resistance at transcriptome level
  Zhigang Hu, Lei Zhou, Tingting He
  The Journal of Sports Medicine and Physical Fitness.2018;[Epub]     CrossRef
• The influence of physical activity on risk of cardiovascular disease in people who are obese but metabolically healthy
  Shinje Moon, Chang-Myung Oh, Moon-Ki Choi, Yoo-Kyung Park, Sukyung Chun, Minkyung Choi, Jae Myung Yu, Hyung Joon Yoo, Pedro Tauler
  PLOS ONE.2017; 12(9): e0185127.     CrossRef
• Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia
  Christopher J. Gaffney, Peter Mansell, Francis B. Stephens, Ian A. Macdonald, Kostas Tsintzas
  Journal of Diabetes Research.2017; 2017: 1.     CrossRef
• Glucose effectiveness, but not insulin sensitivity, is improved after short-term interval training in individuals with type 2 diabetes mellitus: a controlled, randomised, crossover trial
  Kristian Karstoft, Margaret A. Clark, Ida Jakobsen, Sine H. Knudsen, Gerrit van Hall, Bente K. Pedersen, Thomas P. J. Solomon
  Diabetologia.2017; 60(12): 2432.     CrossRef
• Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice
  Tae Woo Jung, Hyoung-Chun Kim, A. M. Abd El-Aty, Ji Hoon Jeong
  Scientific Reports.2017;[Epub]     CrossRef
• Arginine and aerobic training prevent endothelial and metabolic alterations in rats at high risk for the development of the metabolic syndrome
  Renata F. Medeiros, Thaiane G. Gaique, Thais Bento-Bernardes, Raquel Kindlovits, Tamiris M. B. Gomes, Nadia Alice V. Motta, Fernanda Carla Brito, Caroline Fernandes-Santos, Karen J. Oliveira, Antonio Claudio L. Nóbrega
  British Journal of Nutrition.2017; 118(1): 1.     CrossRef
• Effects of Exercise on Type 2 Diabetes Mellitus-Related Cognitive Impairment and Dementia
  Michele Callisaya, Kazunori Nosaka
  Journal of Alzheimer's Disease.2017; 59(2): 503.     CrossRef
• Study of Insulin Resistance in Women with Preeclampsia
  Amit D Sonagra, Asmabi Makandar, Shivaleela M Biradar, Zahoorunissa Deba
  Indian journal of Medical Biochemistry.2017; 21(2): 127.     CrossRef

Obesity resulting from the delivery of an excess amount of energy to adipose tissue from glucose or free fatty acids is associated with insulin resistance and adipose tissue inflammation. Reactive oxygen species (ROS) have been implicated as contributors to both the onset and the progression of insulin resistance. ROS can be generated by overloading the mitochondrial oxidative phosphorylation system, and also by nicotinamide adenine dinucleotide phosphate oxidases (NOX) produced by either adipocytes, which only produce NOX4, or by macrophages, which produce mainly NOX2. The source of the ROS might differ in the early, intermediate and late stages of obesity, switching from NOX4-dependence in the early phases to NOX2-dependence, in the intermediate phase, and transiting to mitochondria-dependence later in the time course of obesity. Thus, depending on the stage of obesity, ROS can be generated by three distinct mechanisms: i.e., NOX4, NOX2, and mitochondria. In this review, we will discuss whether NOX4-, NOX2-, and/or mitochondria-derived ROS is/are causal in the onset of adipocyte insulin resistance as obesity progresses. Moreover, we will review the pathophysiological roles of NOX4, NOX2, and mitochondria-derived ROS on adipose tissue inflammation.

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• The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study
  Mikiko Shibata, Kyoko Kogawa Sato, Hideo Koh, Izumi Shibata, Kaori Okamura, Yuka Takeuchi, Keiko Oue, Michio Morimoto, Tomoshige Hayashi
  Journal of Epidemiology.2024; 34(3): 137.     CrossRef
• Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity
  J. P. Shirley Niveta, Cordelia Mano John, Sumathy Arockiasamy
  Molecular Biology Reports.2024;[Epub]     CrossRef
• The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
  Amir Barzegar Behrooz, Marco Cordani, Alessandra Fiore, Massimo Donadelli, Joseph W. Gordon, Daniel J. Klionsky, Saeid Ghavami
  Seminars in Cancer Biology.2024; 99: 24.     CrossRef
• Pathogenesis and management of diabetic gastroparesis: An updated clinically oriented review
  Srikar Uppaluri, Manisha Ashok Jain, Hira Ali, Jay Shingala, Dhruti Amin, Trisha Ajwani, Irum Fatima, Neil Patel, Nirja Kaka, Yashendra Sethi, Nitin Kapoor
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(3): 102994.     CrossRef
• The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
  Helen Ye Rim Huang, Sarah Badar, Mohammad Said, Siddiqah Shah, Hareesha Rishab Bharadwaj, Krishna Ramamoorthy, Maen Monketh Alrawashdeh, Faaraea Haroon, Jawad Basit, Sajeel Saeed, Narjiss Aji, Gary Tse, Priyanka Roy, Mainak Bardhan
  Molecular Biology Reports.2024;[Epub]     CrossRef
• The complex interplay between oxinflammation, mitochondrial dysfunction and lipotoxicity: Focus on their role in the pathogenesis of skeletal muscle insulin resistance and modulation by dietary fatty acids
  Angelina Passaro, Juana Maria Sanz, Nenad Naumovski, Domenico Sergi
  Advances in Redox Research.2024; 11: 100100.     CrossRef
• Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases
  Biao Li, Wan Li, Tiancai Liu, Longying Zha
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• Oxidative stress in metabolic diseases: current scenario and therapeutic relevance
  Satish K. Raut, Madhu Khullar
  Molecular and Cellular Biochemistry.2023; 478(1): 185.     CrossRef
• Rainbow Trout (Oncorhynchus mykiss) as Source of Multifunctional Peptides with Antioxidant, ACE and DPP-IV Inhibitory Activities
  Martina Bartolomei, Janna Cropotova, Carlotta Bollati, Kristine Kvangarsnes, Lorenza d’Adduzio, Jianqiang Li, Giovanna Boschin, Carmen Lammi
  Nutrients.2023; 15(4): 829.     CrossRef
• Current Status of Obesity: Protective Role of Catechins
  Tanisha Basu, Ashley Selman, Arubala P. Reddy, P. Hemachandra Reddy
  Antioxidants.2023; 12(2): 474.     CrossRef
• Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation
  Nanaka Arimura, Hiroshi Watanabe, Hiromasa Kato, Tadashi Imafuku, Takehiro Nakano, Miyu Sueyoshi, Mayuko Chikamatsu, Kai Tokumaru, Taisei Nagasaki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Toru Maruyama
  Toxins.2023; 15(3): 179.     CrossRef
• The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
  Iwona Świątkiewicz, Marcin Wróblewski, Jarosław Nuszkiewicz, Paweł Sutkowy, Joanna Wróblewska, Alina Woźniak
  International Journal of Molecular Sciences.2023; 24(7): 6382.     CrossRef
• Understanding the Impact of Obesity on Ageing in the Radiance of DNA Metabolism
  S.G. Chowdhury, S. Misra, Parimal Karmakar
  The Journal of nutrition, health and aging.2023; 27(5): 314.     CrossRef
• Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis
  Priyanshy Sharma, V. Sri Swetha Victoria, P. Praneeth Kumar, Sarbani Karmakar, Mudduluru Swetha, Amala Reddy
  International Immunopharmacology.2023; 122: 110472.     CrossRef
• Mechanisms of Formation and Persistence of IgE Products and Potential Innovative Means of Therapy for Allergic Pathologies
  D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
  Applied Biochemistry and Microbiology.2023; 59(6): 754.     CrossRef
• Mechanism and application of Lactobacillus in type 2 diabetes-associated periodontitis
  Sisi Chen, Yuhan Zhang
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Activated monocytes as a therapeutic target to attenuate vascular inflammation and lower cardiovascular disease-risk in patients with type 2 diabetes: A systematic review of preclinical and clinical studies
  Siphamandla R. Ngcobo, Bongani B. Nkambule, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Aviwe Ntsethe, Vuyolwethu Mxinwa, Khanyisani Ziqubu, Yonela Ntamo, Thembeka A. Nyawo, Phiwayinkosi V. Dludla
  Biomedicine & Pharmacotherapy.2022; 146: 112579.     CrossRef
• Genomic Analysis of Visceral Fat Accumulation in Holstein Cows
  Larissa C. Novo, Ligia Cavani, Pablo Pinedo, Pedro Melendez, Francisco Peñagaricano
  Frontiers in Genetics.2022;[Epub]     CrossRef
• Regulation of immune cell function by nicotinamide nucleotide transhydrogenase
  Thomas Regan, Rachel Conway, Leena P. Bharath
  American Journal of Physiology-Cell Physiology.2022; 322(4): C666.     CrossRef
• d-Allulose Ameliorates Hyperglycemia Through IRE1α Sulfonation-RIDD-Sirt1 Decay Axis in the Skeletal Muscle
  Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seon-Ah Park, Juwon Lee, Junghyun Lim, Soonok Sa, Go Eun Kim, Jung Sook Han, Junghyun Kim, Han-Jung Chae
  Antioxidants & Redox Signaling.2022; 37(4-6): 229.     CrossRef
• Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets
  Sinenhlanhla X.H. Mthembu, Sithandiwe E. Mazibuko-Mbeje, Khanyisani Ziqubu, Thembeka A. Nyawo, Nnini Obonye, Tawanda M. Nyambuya, Bongani B. Nkambule, Sonia Silvestri, Luca Tiano, Christo J.F. Muller, Phiwayinkosi V. Dludla
  Life Sciences.2022; 297: 120467.     CrossRef
• The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity
  Judy Fieres, Marvin Fischer, Christine Sauter, Maria Moreno-Villanueva, Alexander Bürkle, Petra H. Wirtz
  DNA Repair.2022; 114: 103323.     CrossRef
• The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics
  Anushka C. Wickramaratne, Li Li, Jesse B. Hopkins, Lukasz A. Joachimiak, Carla B. Green
  Biochemistry.2022; 61(11): 1091.     CrossRef
• Oxidative stress and obesity
  Maja Malenica, Neven Meseldžić
  Arhiv za farmaciju.2022; 72(2): 166.     CrossRef
• Transcriptomic analysis of Simpson Golabi Behmel Syndrome cells during differentiation exhibit BAT-like function
  M. Colitti, U. Ali, M. Wabitsch, D. Tews
  Tissue and Cell.2022; : 101822.     CrossRef
• Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials
  Sebastián Yalle-Vásquez, Karem Osco-Rosales, Wendy Nieto-Gutierrez, Vicente Benites-Zapata, Faustino R. Pérez-López, Christoper A. Alarcon-Ruiz
  Gynecological Endocrinology.2022; 38(7): 548.     CrossRef
• The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity
  Orestes López-Ortega, Nidia Carolina Moreno-Corona, Victor Javier Cruz-Holguin, Luis Didier Garcia-Gonzalez, Addy Cecilia Helguera-Repetto, Mirza Romero-Valdovinos, Haruki Arevalo-Romero, Leticia Cedillo-Barron, Moisés León-Juárez
  International Journal of Molecular Sciences.2022; 23(11): 6154.     CrossRef
• Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review
  Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Tamires da Cunha Soares, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Jennifer Beatriz Silva Morais, Mickael de Paiva Sousa, Thayanne Gabryelle Visgueira de Sousa, Nilmara Cunha da
  Biological Trace Element Research.2022; 200(8): 3545.     CrossRef
• Nrf2a dependent and independent effects of early life exposure to 3,3’-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio)
  Monika A. Roy, Charlotte K. Gridley, Sida Li, Yeonhwa Park, Alicia R. Timme-Laragy
  Aquatic Toxicology.2022; 249: 106219.     CrossRef
• Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats
  Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Sheu Oluwadare Sulaiman, Edwin Coleridge Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu
  IBRO Neuroscience Reports.2022; 13: 57.     CrossRef
• Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
  Chung-Lin Jiang, Chang-Yu Tsao, Yi-Ching Lee
  Genes & Nutrition.2022;[Epub]     CrossRef
• Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions
  Xiujuan Wang, Meihong Xu, Yong Li
  Nutrients.2022; 14(15): 3134.     CrossRef
• Production of Reactive Oxygen Species by Epicardial Adipocytes Is Associated with an Increase in Postprandial Glycemia, Postprandial Insulin, and a Decrease in Serum Adiponectin in Patients with Severe Coronary Atherosclerosis
  Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Kharitonova, Sergey L. Andreev, Alexander S. Gorbunov, Boris K. Kurbatov, Alla A. Boshchenko
  Biomedicines.2022; 10(8): 2054.     CrossRef
• Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer
  Konstantinos Prokopidis, Panagiotis Giannos, Oliver C. Witard, Daniel Peckham, Theocharis Ispoglou, Ajay Pratap Singh
  PLOS ONE.2022; 17(9): e0273766.     CrossRef
• Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress
  Mark F. McCarty, James J. DiNicolantonio, James H. O’Keefe
  Current Issues in Molecular Biology.2022; 44(9): 4314.     CrossRef
• Fructose promotes more than glucose the adipocytic differentiation of pig mesenchymal stem cells
  Francisco Campos‐Maldonado, María L. González‐Dávalos, Enrique Piña, Miriam Aracely Anaya‐Loyola, Armando Shimada, Alfredo Varela‐Echavarria, Ofelia Mora
  Journal of Food Biochemistry.2022;[Epub]     CrossRef
• Understanding the effect of obesity on papillary thyroid cancer: is there a need for tailored diagnostic and therapeutic management?
  Antonio Matrone, Alessio Basolo, Ferruccio Santini, Rossella Elisei
  Expert Review of Endocrinology & Metabolism.2022; 17(6): 475.     CrossRef
• The Role of Inflammation as a Preponderant Risk Factor in Cardiovascular Diseases
  Rodrigo Damián García, Joana Antonela Asensio, Diahann Jeanette Perdicaro, María de los Ángeles Peral
  Current Vascular Pharmacology.2022; 20(3): 244.     CrossRef
• Synthesis and Catalytic Studies of Nanoalloy Particles Based on Bismuth, Silver, and Rhenium
  Konrad Wojtaszek, Katarzyna Skibińska, Filip Cebula, Tomasz Tokarski, Marc Escribà-Gelonch, Volker Hessel, Marek Wojnicki
  Metals.2022; 12(11): 1819.     CrossRef
• Endothelium-Derived Relaxing Factors and Endothelial Function: A Systematic Review
  Francesco Nappi, Antonio Fiore, Joyce Masiglat, Teresa Cavuoti, Michela Romandini, Pierluigi Nappi, Sanjeet Singh Avtaar Singh, Jean-Paul Couetil
  Biomedicines.2022; 10(11): 2884.     CrossRef
• MicroRNAs in the Regulation of NADPH Oxidases in Vascular Diabetic and Ischemic Pathologies: A Case for Alternate Inhibitory Strategies?
  Sean R. Wallace, Patrick J. Pagano, Damir Kračun
  Antioxidants.2022; 12(1): 70.     CrossRef
• Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance
  Yujeong Kim, Ok-Kyung Kim
  Advances in Nutrition.2021; 12(2): 566.     CrossRef
• Mesenchymal stem cell conditioned medium ameliorates diabetic serum‐induced insulin resistance in 3T3‐L1 cells
  Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
  Chronic Diseases and Translational Medicine.2021; 7(1): 47.     CrossRef
• F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes
  M. T. Kaartinen, M. Arora, S. Heinonen, A. Hang, A. Barry, J. Lundbom, A. Hakkarainen, N. Lundholm, A. Rissanen, J. Kaprio, K. H. Pietiläinen
  International Journal of Obesity.2021; 45(3): 577.     CrossRef
• Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer – Pooled results of 24 million cohorts
  Mohanad R. Youssef, Adin S.C. Reisner, Abdallah S. Attia, Mohamed Hosny Hussein, Mahmoud Omar, Anna LaRussa, Carlos A. Galvani, Mohamed Aboueisha, Mohamed Abdelgawad, Eman Ali Toraih, Gregory W. Randolph, Emad Kandil
  Oral Oncology.2021; 112: 105085.     CrossRef
• Thioredoxin deficiency exacerbates vascular dysfunction during diet‐induced obesity in small mesenteric artery in mice
  Shannon Dunn, Robert H. Hilgers, Kumuda C. Das
  Microcirculation.2021;[Epub]     CrossRef
• Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes
  Mariana Grancieri, Hércia Stampini Duarte Martino, Elvira Gonzalez de Mejia
  Nutrients.2021; 13(1): 176.     CrossRef
• The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity
  Yawen Zhou, Huige Li, Ning Xia
  Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
• Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
  Safaa H. Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H. Eid, Assaad A. Eid, Ahmed F. El-Yazbi
  Biochemical Pharmacology.2021; 186: 114491.     CrossRef
• Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents
  Li Xiao, Nobuhiko Miwa
  Cells.2021; 10(3): 626.     CrossRef
• Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
  Štěpánka Benáková, Blanka Holendová, Lydie Plecitá-Hlavatá
  Antioxidants.2021; 10(4): 526.     CrossRef
• Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes
  Mengqi Zeng, Jie Xu, Zhengyi Zhang, Xuan Zou, Xueqiang Wang, Ke Cao, Weiqiang Lv, Yuting Cui, Jiangang Long, Zhihui Feng, Jiankang Liu
  Redox Biology.2021; 41: 101948.     CrossRef
• Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
  Mark F. McCarty
  International Journal of Molecular Sciences.2021; 22(7): 3321.     CrossRef
• Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry
  Pamela A. Nono Nankam, Télesphore B. Nguelefack, Julia H. Goedecke, Matthias Blüher
  Antioxidants.2021; 10(4): 622.     CrossRef
• Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats
  Joanna Sadowska, Wioleta Dudzińska, Izabela Dziaduch, Mahmoud A.O. Dawood
  PLOS ONE.2021; 16(5): e0251789.     CrossRef
• Oxidative stress in oocyte aging and female reproduction
  Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
  Journal of Cellular Physiology.2021; 236(12): 7966.     CrossRef
• Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation
  Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni
  BioFactors.2021; 47(5): 837.     CrossRef
• Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals
  Letícia Mattei, Fabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Artur Junio Togneri Ferron, Carol Cristina Vágula de Almeida Silva, Cristina Schmitt Gregolin, Erika Tiemi Nakandakare-Maia, Janaína das Chagas Paixão Silva, Fernando Moreto, Igo
  Molecular and Cellular Endocrinology.2021; 537: 111423.     CrossRef
• Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses
  Lovro Žiberna, Zala Jenko-Pražnikar, Ana Petelin
  Antioxidants.2021; 10(9): 1352.     CrossRef
• The level of reactive oxygen species production by adipocytes of epicardial adipose tissue is associated with an increase in postprandial glycemia in patients with severe coronary atherosclerosis
  O. A. Koshelskaya, N. V. Naryzhnaya, I. V. Kologrivova, T. E. Suslova, O. A. Kharitonova, V. V. Evtushenko, S. L. Andreev, A. S. Gorbunov, A. A. Gudkova
  The Siberian Journal of Clinical and Experimental Medicine.2021; 36(3): 59.     CrossRef
• Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
  Amy E. Mendham, Steen Larsen, Cindy George, Kevin Adams, Jon Hauksson, Tommy Olsson, Melony C. Fortuin-de Smidt, Pamela A. Nono Nankam, Olah Hakim, Louise M. Goff, Carmen Pheiffer, Julia H. Goedecke
  Scientific Reports.2020;[Epub]     CrossRef
• Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes
  Su-Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Seung-Soon Im, Jae-Hoon Bae, Dae-Kyu Song
  Redox Biology.2020; 37: 101749.     CrossRef
• Pathogenic Role of Air Pollution Particulate Matter in Cardiometabolic Disease: Evidence from Mice and Humans
  Timoteo Marchini, Andreas Zirlik, Dennis Wolf
  Antioxidants & Redox Signaling.2020; 33(4): 263.     CrossRef
• Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte
  Allison M. Manuel, Michael D. Walla, Margaret T. Dorn, Ross M. Tanis, Gerardo G. Piroli, Norma Frizzell
  Free Radical Biology and Medicine.2020; 148: 70.     CrossRef
• TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women
  Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka
  Molecular Biology Reports.2020; 47(2): 855.     CrossRef
• Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows
  G. Andres Contreras, Jenne De Koster, Jonas de Souza, Juliana Laguna, Vengai Mavangira, Rahul K. Nelli, Jeff Gandy, Adam L. Lock, Lorraine M. Sordillo
  Journal of Dairy Science.2020; 103(2): 1944.     CrossRef
• Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
  Bianka Bojková, Pawel J. Winklewski, Magdalena Wszedybyl-Winklewska
  International Journal of Molecular Sciences.2020; 21(11): 4114.     CrossRef
• Adipose tissue macrophages: Unique polarization and bioenergetics in obesity
  Heather L. Caslin, Monica Bhanot, W. Reid Bolus, Alyssa H. Hasty
  Immunological Reviews.2020; 295(1): 101.     CrossRef
• Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases
  Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
  European Journal of Pharmacology.2020; 881: 173215.     CrossRef
• Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro
  María Herranz-López, Mariló Olivares-Vicente, Esther Rodríguez Gallego, Jose Antonio Encinar, Almudena Pérez-Sánchez, Verónica Ruiz-Torres, Jorge Joven, Enrique Roche, Vicente Micol
  Food and Chemical Toxicology.2020; 144: 111606.     CrossRef
• Elastin-derived peptide VGVAPG decreases differentiation of mouse embryo fibroblast (3T3-L1) cells into adipocytes
  Konrad A. Szychowski, Bartosz Skóra, Jakub Tobiasz, Jan Gmiński
  Adipocyte.2020; 9(1): 234.     CrossRef
• Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications
  John O. Orgah, Shuang He, Yule Wang, Miaomiao Jiang, Yuefei Wang, Emmanuel A. Orgah, Yajun Duan, Buchang Zhao, Boli Zhang, Jihong Han, Yan Zhu
  Pharmacological Research.2020; 153: 104654.     CrossRef
• Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes
  Teresa Vezza, Zaida Abad-Jiménez, Miguel Marti-Cabrera, Milagros Rocha, Víctor Manuel Víctor
  Antioxidants.2020; 9(9): 848.     CrossRef
• Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
  Mari T. Kaartinen, Mansi Arora, Sini Heinonen, Aila Rissanen, Jaakko Kaprio, Kirsi H. Pietiläinen
  International Journal of Molecular Sciences.2020; 21(21): 8289.     CrossRef
• Phytosterols: Nutritional Health Players in the Management of Obesity and Its Related Disorders
  Teresa Vezza, Francisco Canet, Aranzazu M. de Marañón, Celia Bañuls, Milagros Rocha, Víctor Manuel Víctor
  Antioxidants.2020; 9(12): 1266.     CrossRef
• Metabolic programming of macrophage functions and pathogens control
  Sue-jie Koo, Nisha J. Garg
  Redox Biology.2019; 24: 101198.     CrossRef
• Effects of bariatric surgery on telomere length and T-cell aging
  F. Jongbloed, R. W. J. Meijers, J. N. M. IJzermans, R. A. Klaassen, M. E. T. Dollé, S. van den Berg, M. G. H. Betjes, R. W. F. de Bruin, E. van der Harst, N. H. R. Litjens
  International Journal of Obesity.2019; 43(11): 2189.     CrossRef
• Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
  Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder, Michael Berk
  Neuroscience & Biobehavioral Reviews.2019; 107: 862.     CrossRef
• Adipose oxidative stress and protein carbonylation
  Amy K. Hauck, Yimao Huang, Ann V. Hertzel, David A. Bernlohr
  Journal of Biological Chemistry.2019; 294(4): 1083.     CrossRef
• Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis
  Priyanka Sarkar, Kavitha Thirumurugan
  Journal of Functional Foods.2019; 53: 318.     CrossRef
• Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
  Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
  Diabetologia.2019; 62(5): 779.     CrossRef
• Obesity, DNA Damage, and Development of Obesity-Related Diseases
  Marta Włodarczyk, Grażyna Nowicka
  International Journal of Molecular Sciences.2019; 20(5): 1146.     CrossRef
• Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
  Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
  Scientific Reports.2019;[Epub]     CrossRef
• The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology
  Evan DeVallance, Yao Li, Michael J. Jurczak, Eugenia Cifuentes-Pagano, Patrick J. Pagano
  Antioxidants & Redox Signaling.2019; 31(10): 687.     CrossRef
• Phenolic compounds as natural and multifunctional anti-obesity agents: A review
  Celia Rodríguez-Pérez, Antonio Segura-Carretero, María del Mar Contreras
  Critical Reviews in Food Science and Nutrition.2019; 59(8): 1212.     CrossRef
• Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C
  Eraci Drehmer, Mari Ángeles Navarro-Moreno, Sandra Carrera, Vincent M. Villar, Mari Luz Moreno
  Food & Function.2019; 10(6): 3567.     CrossRef
• High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production
  Tareck Rharass, Stéphanie Lucas
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation
  Pratik Adhya, Shyam Sunder Sharma
  Pharmacological Research.2019; 146: 104271.     CrossRef
• Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
  Maria A. Pabon, Kevin Manocha, Jim W. Cheung, James C. Lo
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Strawberry extract attenuates oxidative stress in 3T3-L1 cells
  Tamara Y. Forbes-Hernández, Sadia Afrin, Danila Cianciosi, Piera Pia Manna, Jiaojiao Zhang, Massimiliano Gasparrini, Patricia Reboredo-Rodríguez
  Journal of Berry Research.2018; 8(3): 193.     CrossRef
• The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
  Hyon-Seung Yi, Joon Young Chang, Minho Shong
  Journal of Molecular Endocrinology.2018; 61(3): R91.     CrossRef
• Emerging Roles for Adipose Tissue in Cardiovascular Disease
  Elizabeth E. Ha, Robert C. Bauer
  Arteriosclerosis, Thrombosis, and Vascular Biology.2018;[Epub]     CrossRef
• miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway
  Yao Gao, Yan Cao, Xianwei Cui, Xingyun Wang, Yahui Zhou, Fangyan Huang, Xing Wang, Juan Wen, Kaipeng Xie, Pengfei Xu, Xirong Guo, Lianghui You, Chenbo Ji
  Molecular and Cellular Endocrinology.2018; 476: 155.     CrossRef
• Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
  Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
  Scientific Reports.2018;[Epub]     CrossRef
• Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells
  Eun-Bin Kwon, Myung-Ji Kang, Soo-Yeon Kim, Yong-Moon Lee, Mi-Kyeong Lee, Heung Joo Yuk, Hyung Won Ryu, Su Ui Lee, Sei-Ryang Oh, Dong-Oh Moon, Hyun-Sun Lee, Mun-Ock Kim
  Evidence-Based Complementary and Alternative Medicine.2018; 2018: 1.     CrossRef
• Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet
  Alice Martinic, Javad Barouei, Zach Bendiks, Darya Mishchuk, Dustin D. Heeney, Roy Martin, Maria L. Marco, Carolyn M. Slupsky
  Journal of Proteome Research.2018; 17(8): 2790.     CrossRef
• The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
  Xuan Wang, Andris Elksnis, Per Wikström, Erik Walum, Nils Welsh, Per-Ola Carlsson, Harald H. H. W. Schmidt
  PLOS ONE.2018; 13(9): e0204271.     CrossRef
• Involvement of adipose tissue inflammation and dysfunction in virus-induced type 1 diabetes
  James C Needell, Madalyn N Brown, Danny Zipris
  Journal of Endocrinology.2018; 238(1): 61.     CrossRef
• Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
  Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers, Jun Ren
  Pharmacology & Therapeutics.2018; 191: 1.     CrossRef
• Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid
  Phiwayinkosi Dludla, Bongani Nkambule, Babalwa Jack, Zibusiso Mkandla, Tinashe Mutize, Sonia Silvestri, Patrick Orlando, Luca Tiano, Johan Louw, Sithandiwe Mazibuko-Mbeje
  Nutrients.2018; 11(1): 23.     CrossRef
• Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity
  Laura J. Den Hartigh, Mohamed Omer, Leela Goodspeed, Shari Wang, Tomasz Wietecha, Kevin D. O’Brien, Chang Yeop Han
  Arteriosclerosis, Thrombosis, and Vascular Biology.2017; 37(3): 466.     CrossRef
• Novel lipid-mimetic prodrugs delivering active compounds to adipose tissue
  Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
  European Journal of Medicinal Chemistry.2017; 135: 77.     CrossRef
• Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients
  Morana Jaganjac, Shamma Almuraikhy, Fatima Al-Khelaifi, Mashael Al-Jaber, Moataz Bashah, Nayef A. Mazloum, Kamelija Zarkovic, Neven Zarkovic, Georg Waeg, Wael Kafienah, Mohamed A. Elrayess
  Redox Biology.2017; 12: 483.     CrossRef
• A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
  Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
  Endocrinology and Metabolism.2017; 32(3): 375.     CrossRef
• Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
  Maimaiti Yisireyili, Motoharu Hayashi, Hongxian Wu, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Mohammad Shoaib Hamrah, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toshimitsu Niwa, Toyoaki Murohara, Kyosuke Takeshita
  Scientific Reports.2017;[Epub]     CrossRef
• Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress
  Adriana Rosas-Villegas, Mónica Sánchez-Tapia, Azalia Avila-Nava, Victoria Ramírez, Armando Tovar, Nimbe Torres
  Nutrients.2017; 9(4): 393.     CrossRef
• Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome
  Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena María Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones
  Metabolism.2017; 71: 132.     CrossRef
• Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling
  Ann V. Hertzel, Hongliang Xu, Michael Downey, Nicholas Kvalheim, David A. Bernlohr
  Journal of Lipid Research.2017; 58(7): 1354.     CrossRef
• Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
  Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
  Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
• Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice
  Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
  Vascular Pharmacology.2017; 96-98: 19.     CrossRef
• Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
  Anil Bhatta, Lin Yao, Zhimin Xu, Haroldo A. Toque, Jijun Chen, Reem T. Atawia, Abdelrahman Y. Fouda, Zsolt Bagi, Rudolf Lucas, Ruth B. Caldwell, Robert W. Caldwell
  Cardiovascular Research.2017; 113(13): 1664.     CrossRef
• Change in serum albumin concentration is inversely and independently associated with risk of incident metabolic syndrome
  Sang-Man Jin, Yong Joo Hong, Jae Hwan Jee, Ji Cheol Bae, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
  Metabolism.2016; 65(11): 1629.     CrossRef

In the early 2000s, the prevalence of diabetes in adults aged ≥30 years in Korea was about 9% to 10%, and it remained stable. However, a nationwide survey showed that this prevalence increased over the past few years. After age-standardization using the Korean population of the year 2010, the prevalence of diabetes in adults aged ≥30 years was 10.0% to 10.8% between 2001 and 2012, which increased to 12.5% in 2013 and 11.6% in 2014. During that period, there have been changes in the gender- and age-specific prevalence of diabetes in Korean adults. The prevalence of diabetes in the elderly population increased significantly, while this prevalence in young adults, especially in young women, did not change significantly. The contribution of each diabetic risk factor, such as obesity, β-cell dysfunction, sarcopenia, and socioeconomic status, in developing diabetes has also changed during that period in each gender and age group. For young women, obesity was the most important risk factor; by contrast, for elderly diabetic patients, sarcopenia was more important than obesity as a risk factor. Considering the economic burden of diabetes and its associated comorbidities, a public health policy targeting the major risk factors in each population might be more effective in preventing diabetes.

Citations

Citations to this article as recorded by  

• Real-World Outcomes of Individualized Targeted Therapy with Insulin Glargine 300 Units/mL in Insulin-Naïve Korean People with Type 2 Diabetes: TOBE Study
  Eun-Gyoung Hong, Kyung-Wan Min, Jung Soo Lim, Kyu-Jeung Ahn, Chul Woo Ahn, Jae-Myung Yu, Hye Soon Kim, Hyun Jin Kim, Won Kim, Dong Han Kim, Hak Chul Jang
  Advances in Therapy.2024;[Epub]     CrossRef
• Plasma glucose levels and diabetes are independent predictors for mortality in patients with COVID-19
  Hui Long, Jiachen Li, Rui Li, Haiyang Zhang, Honghan Ge, Hui Zeng, Xi Chen, Qingbin Lu, Wanli Jiang, Haolong Zeng, Tianle Che, Xiaolei Ye, Liqun Fang, Ying Qin, Qiang Wang, Qingming Wu, Hao Li, Wei Liu
  Epidemiology and Infection.2022;[Epub]     CrossRef
• Type 2 Diabetes Mellitus with Early Dry Skin Disorder: A Comparison Study Between Primary and Tertiary Care in Indonesia
  Lili Legiawati, Kusmarinah Bramono, Wresti Indriatmi, Em Yunir, Aditya Indra Pratama
  Current Diabetes Reviews.2022;[Epub]     CrossRef
• Physical Comorbidity According to Diagnoses and Sex among Psychiatric Inpatients in South Korea
  Suin Park, Go-Un Kim, Hyunlye Kim
  International Journal of Environmental Research and Public Health.2021; 18(8): 4187.     CrossRef
• Muscle strength, an independent determinant of glycemic control in older adults with long-standing type 2 diabetes: a prospective cohort study
  Bo Kyung Koo, Seoil Moon, Min Kyong Moon
  BMC Geriatrics.2021;[Epub]     CrossRef
• Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
  Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
  The Korean Journal of Internal Medicine.2020; 35(3): 641.     CrossRef
• Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus
  Soo Kyoung Kim, Jaehoon Jung, Jung Hwa Jung, NalAe Yoon, Sang Soo Kang, Gu Seob Roh, Jong Ryeal Hahm
  Complementary Therapies in Medicine.2020; 52: 102524.     CrossRef
• Taking metformin and cognitive function change in older patients with diabetes
  Bo Kyung Koo, Lee‐Kyung Kim, Jun‐Young Lee, Min Kyong Moon
  Geriatrics & Gerontology International.2019; 19(8): 755.     CrossRef
• Trends in Diabetes Prevalence, Awareness, Treatment and Control in Yangon Region, Myanmar, Between 2004 and 2014, Two Cross-Sectional Studies
  Wai Phyo Aung, Espen Bjertness, Aung Soe Htet, Hein Stigum, Marte Karoline Råberg Kjøllesdal
  International Journal of Environmental Research and Public Health.2019; 16(18): 3461.     CrossRef
• Validity of Japanese version of SARC‐F questionnaire in patients with chronic liver disease
  Satoshi Ida, Yuji Kojima, Shima Hamaoka, Naohito Urawa, Jun Araki, Ryutaro Kaneko, Kazuya Murata
  Journal of Gastroenterology and Hepatology.2019; 34(5): 947.     CrossRef
• Letter: Projection of Diabetes Prevalence in Korean Adults for the Year 2030 Using Risk Factors Identified from National Data (Diabetes Metab J 2019;43:90–6)
  Bo Kyung Koo
  Diabetes & Metabolism Journal.2019; 43(2): 242.     CrossRef
• Antidiabetic Effects of Vigna nakashimae Extract in Humans: A Preliminary Study
  Soo Kyoung Kim, Jaehoon Jung, Jung Hwa Jung, Byong Won Lee, Sang Soo Kang, Gu Seob Roh, Jong Ryeal Hahm
  The Journal of Alternative and Complementary Medicine.2018; 24(3): 249.     CrossRef
• Serum Betatrophin Concentrations and the Risk of Incident Diabetes: A Nested Case-Control Study from Chungju Metabolic Disease Cohort
  Seung-Hwan Lee, Marie Rhee, Hyuk-Sang Kwon, Yong-Moon Park, Kun-Ho Yoon
  Diabetes & Metabolism Journal.2018; 42(1): 53.     CrossRef
• Relationship between age and cardiometabolic index in Japanese men and women
  Ichiro Wakabayashi
  Obesity Research & Clinical Practice.2018; 12(4): 372.     CrossRef
• Kidney transplantation in patients with diabetes: better than nothing
  Chang Seong Kim
  The Korean Journal of Internal Medicine.2018; 33(2): 293.     CrossRef
• The Changes of Macular Microvasculature and Related Systemic Parameters in Diabetic Patients without Diabetic Retinopathy
  Sang Wook Choi, Joon Hee Cho, Ha Kyung Kim, So Hyun Bae
  Journal of the Korean Ophthalmological Society.2017; 58(7): 811.     CrossRef
• Dietary total, animal, vegetable calcium and type 2 diabetes incidence among Korean adults: The Korean Multi-Rural Communities Cohort (MRCohort)
  J.M. Oh, H.W. Woo, M.K. Kim, Y.-H. Lee, D.H. Shin, M.-H. Shin, B.Y. Choi
  Nutrition, Metabolism and Cardiovascular Diseases.2017; 27(12): 1152.     CrossRef
• The Influence of Prenatal Exercise on Offspring Health: A Review
  Carmen Moyer, Olga Roldan Reoyo, Linda May
  Clinical Medicine Insights: Women's Health.2016; 9: CMWH.S34670.     CrossRef

Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a complex and progressive pathogenesis. The two primary mechanisms of T2DM pathogenesis are pancreatic β-cell dysfunction and insulin resistance. Pancreatic β-cell dysfunction is recognized to be a prerequisite for the development of T2DM. Therapeutic modalities that improve β-cell function are considered critical to T2DM management; however, blood glucose control remains a challenge for many patients due to suboptimal treatment efficacy and the progressive nature of T2DM. Incretin-based therapies are now the most frequently prescribed antidiabetic drugs in Korea. Incretin-based therapies are a favorable class of drugs due to their ability to reduce blood glucose by targeting the incretin hormone system and, most notably, their potential to improve pancreatic β-cell function. This review outlines the current understanding of the incretin hormone system in T2DM and summarizes recent updates on the effect of incretin-based therapies on β-cell function and β-cell mass in animals and humans.

Citations

Citations to this article as recorded by  

• Harnessing gut cells for functional insulin production: Strategies and challenges
  Kelvin Baafi, John C. March
  Biotechnology Notes.2023; 4: 7.     CrossRef
• Incretin and Pancreatic β-Cell Function in Patients with Type 2 Diabetes
  Chang Ho Ahn, Tae Jung Oh, Se Hee Min, Young Min Cho
  Endocrinology and Metabolism.2023; 38(1): 1.     CrossRef
• Weight loss maintenance with exercise and liraglutide improves glucose tolerance, glucagon response, and beta cell function
  Simon B. K. Jensen, Christian R. Juhl, Charlotte Janus, Julie R. Lundgren, Christoffer Martinussen, Christoffer Wiingaard, Cecilie Knudsen, Ruth Frikke‐Schmidt, Bente M. Stallknecht, Jens J. Holst, Sten Madsbad, Signe S. Torekov
  Obesity.2023; 31(4): 977.     CrossRef
• How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and β-cell crosstalk
  Inah Camaya, Bronwyn O’Brien, Sheila Donnelly
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• An Imbalance of Pathophysiologic Factors in Late Postprandial Hypoglycemia Post Bariatric Surgery: A Narrative Review
  Marah Alsayed Hasan, Stanley Schwartz, Victoria McKenna, Richard Ing
  Obesity Surgery.2023; 33(9): 2927.     CrossRef
• Therapeutic Dilemma in Personalized Medicine
  Ehab S. EL Desoky
  Current Reviews in Clinical and Experimental Pharmacology.2022; 17(2): 94.     CrossRef
• Lessons from neonatal β-cell epigenomic for diabetes prevention and treatment
  Amar Abderrahmani, Cécile Jacovetti, Romano Regazzi
  Trends in Endocrinology & Metabolism.2022; 33(6): 378.     CrossRef
• Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists
  Neil Tanday, Ryan A. Lafferty, Peter R. Flatt, Nigel Irwin
  Diabetes, Obesity and Metabolism.2022; 24(12): 2353.     CrossRef
• A Randomized Controlled Trial of R-Form Verapamil Added to Ongoing Metformin Therapy in Patients with Type 2 Diabetes
  Chih-Yuan Wang, Kuo-Chin Huang, Chia-Wen Lu, Chih-Hsun Chu, Chien-Ning Huang, Harn-Shen Chen, I-Te Lee, Jung-Fu Chen, Ching-Chu Chen, Chung-Sen Chen, Chang-Hsun Hsieh, Kai-Jen Tien, Hung-Yu Chien, Yu-Yao Huang, Jui-Pao Hsu, Guang-Tzuu Shane, Ai-Ching Chan
  The Journal of Clinical Endocrinology & Metabolism.2022; 107(10): e4063.     CrossRef
• Exenatide, Metformin, or Both for Prediabetes in PCOS: A Randomized, Open-label, Parallel-group Controlled Study
  Tao Tao, Yi Zhang, Yu-Chen Zhu, Jia-Rong Fu, Yu-Ying Wang, Jie Cai, Jing-Yu Ma, Yu Xu, Yi-Ning Gao, Yun Sun, WuQiang Fan, Wei Liu
  The Journal of Clinical Endocrinology & Metabolism.2021; 106(3): e1420.     CrossRef
• The utility of assessing C-peptide in patients with insulin-treated type 2 diabetes: a cross-sectional study
  Tuccinardi Dario, Giorgino Riccardo, Pieralice Silvia, Watanabe Mikiko, Maggi Daria, Palermo Andrea, Defeudis Giuseppe, Fioriti Elvira, Pozzilli Paolo, Manfrini Silvia
  Acta Diabetologica.2021; 58(4): 411.     CrossRef
• Type 2 diabetes: evidence-based medicine approach to glucose-lowering therapy
  E. V. Biryukova, I. A. Morozova, S. V. Rodionova
  Meditsinskiy sovet = Medical Council.2021; (21): 160.     CrossRef
• Emerging Role of Caveolin-1 in GLP-1 Action
  Alessandra Puddu, Davide Maggi
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Improvements in HOMA indices and pancreatic endocrinal tissues in type 2-diabetic rats by DPP-4 inhibition and antioxidant potential of an ethanol fruit extract of Withania coagulans
  Heera Ram, Pramod Kumar, Ashok Purohit, Priya Kashyap, Suresh Kumar, Shivani Kumar, Garima Singh, Abdulaziz A. Alqarawi, Abeer Hashem, Elsayed Fathi Abd-Allah, Al-Bandari Fahad Al-Arjani, Bhim Pratap Singh
  Nutrition & Metabolism.2021;[Epub]     CrossRef
• Chop / Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice
  Jing Yong, Vishal S. Parekh, Shannon M. Reilly, Jonamani Nayak, Zhouji Chen, Cynthia Lebeaupin, Insook Jang, Jiangwei Zhang, Thazha P. Prakash, Hong Sun, Sue Murray, Shuling Guo, Julio E. Ayala, Leslie S. Satin, Alan R. Saltiel, Randal J. Kaufman
  Science Translational Medicine.2021;[Epub]     CrossRef
• Assessment of Insulin Secretion and Insulin Resistance in Human
  So Young Park, Jean-François Gautier, Suk Chon
  Diabetes & Metabolism Journal.2021; 45(5): 641.     CrossRef
• Targeted pharmacological therapy restores β-cell function for diabetes remission
  Stephan Sachs, Aimée Bastidas-Ponce, Sophie Tritschler, Mostafa Bakhti, Anika Böttcher, Miguel A. Sánchez-Garrido, Marta Tarquis-Medina, Maximilian Kleinert, Katrin Fischer, Sigrid Jall, Alexandra Harger, Erik Bader, Sara Roscioni, Siegfried Ussar, Annett
  Nature Metabolism.2020; 2(2): 192.     CrossRef
• The Relationship Between Timing of Initiation on a Glucagon-like Peptide-1 Receptor Agonist and Glycosylated Hemoglobin Values Among Patients With Type 2 Diabetes
  Kristina S. Boye, Reema Mody, Maureen J. Lage, Raleigh E. Malik
  Clinical Therapeutics.2020; 42(9): 1812.     CrossRef
• Short-term renal and metabolic effects of low dose vildagliptin treatment added-on insulin therapy in non-proteinuric patients with type 2 diabetes: open-label randomized prospective study
  Valentina K. Bayrasheva, Ivan Y. Pchelin, Vladimir A. Dobronravov, Alina Yu. Babenko, Svetlana G. Chefu, Ivan S. Shatalov, Volha N. Vasilkova, Natalia V. Hudiakova, Alexandra N. Ivanova, Pavel A. Andoskin, Elena N. Grineva
  Archives of Endocrinology and Metabolism.2020;[Epub]     CrossRef
• A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity
  Jennifer Vogel, Jianning Yin, Liansheng Su, Sharon X. Wang, Richard Zessis, Sena Fowler, Chun-Hao Chiu, Aaron C. Wilson, Amy Chen, Frederic Zecri, Gordon Turner, Thomas M. Smith, Brian DeChristopher, Heming Xing, Deborah M. Rothman, Xinming Cai, Alina Ber
  Diabetes.2020; 69(5): 1032.     CrossRef
• Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice
  Gaëtan Prévost, Arnaud Arabo, Marie-Anne Le Solliec, Justine Bons, Marie Picot, Julie Maucotel, Hind Berrahmoune, Mouna El Mehdi, Saloua Cherifi, Alexandre Benani, Emmanuelle Nédélec, Moïse Coëffier, Jérôme Leprince, Anneli Nordqvist, Valéry Brunel, Pierr
  American Journal of Physiology-Endocrinology and Metabolism.2019; 317(1): E147.     CrossRef
• Gastrin analogue administration adds no significant glycaemic benefit to a glucagon‐like peptide‐1 receptor agonist acutely or after washout of both analogues
  Krister Bokvist, Ying Ding, William H. Landschulz, Vikram Sinha, Aleksandra Pastrak, Ruth M. Belin
  Diabetes, Obesity and Metabolism.2019; 21(7): 1606.     CrossRef
• Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1
  Lie-Chwen Lin, Lin-Chien Lee, Cheng Huang, Chiung-Tong Chen, Jen-Shin Song, Young-Ji Shiao, Hui-Kang Liu
  Phytomedicine.2019; 62: 152946.     CrossRef
• The future of new drugs for diabetes management
  Clifford J. Bailey, Caroline Day
  Diabetes Research and Clinical Practice.2019; 155: 107785.     CrossRef
• Compact fluidic system for functional assessment of pancreatic islets
  Takeshi Hori, Kei Yamane, Takayuki Anazawa, Osamu Kurosawa, Hiroo Iwata
  Biomedical Microdevices.2019;[Epub]     CrossRef
• Pharmacokinetics of Exenatide in nonhuman primates following its administration in the form of sustained-release PT320 and Bydureon
  Yazhou Li, Kelli L. Vaughan, David Tweedie, Jin Jung, Hee Kyung Kim, Ho-Il Choi, Dong Seok Kim, Julie A. Mattison, Nigel H. Greig
  Scientific Reports.2019;[Epub]     CrossRef
• Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injury
  Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
  Neurobiology of Disease.2019; 124: 439.     CrossRef
• Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential
  N.M. Pathak, V. Pathak, V.A. Gault, S. McClean, N. Irwin, P.R. Flatt
  Biochemical Pharmacology.2018; 155: 264.     CrossRef
• Human EndoC-βH1 β-cells form pseudoislets with improved glucose sensitivity and enhanced GLP-1 signaling in the presence of islet-derived endothelial cells
  Michael G. Spelios, Lauren A. Afinowicz, Regine C. Tipon, Eitan M. Akirav
  American Journal of Physiology-Endocrinology and Metabolism.2018; 314(5): E512.     CrossRef
• Vildagliptin: ten years in the service for type 2 diabetes mellitus patients. The journey of discovery, innovation and success in clinical practice
  Tatiana Yu. Demidova
  Problems of Endocrinology.2018; 64(5): 336.     CrossRef
• Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss
  Paola Simeone, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Maria Guagnano, Armando Tartaro, Riccardo Bonadonna, Virginia Federico, Francesco Cipollone, Agostino Consoli, Francesca Santilli
  Nutrients.2018; 10(12): 1872.     CrossRef
• Nutrient regulation of β-cell function: what do islet cell/animal studies tell us?
  R Carlessi, K N Keane, C Mamotte, P Newsholme
  European Journal of Clinical Nutrition.2017; 71(7): 890.     CrossRef
• Effectiveness and safety of exenatide in Korean patients with type 2 diabetes inadequately controlled with oral hypoglycemic agents: an observational study in a real clinical practice
  You-Cheol Hwang, Ari Kim, Euna Jo, Yeoree Yang, Jae-Hyoung Cho, Byung-Wan Lee
  BMC Endocrine Disorders.2017;[Epub]     CrossRef
• Efficacy and safety of adding evogliptin versus sitagliptin for metformin‐treated patients with type 2 diabetes: A 24‐week randomized, controlled trial with open label extension
  Sang‐Mo Hong, Cheol‐Young Park, Dong‐Min Hwang, Kyung Ah Han, Chang Beom Lee, Choon Hee Chung, Kun‐Ho Yoon, Ji‐Oh Mok, Kyong Soo Park, Sung‐Woo Park
  Diabetes, Obesity and Metabolism.2017; 19(5): 654.     CrossRef
• The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)
  Naoyuki Kitao, Hideaki Miyoshi, Tomoo Furumoto, Kota Ono, Hiroshi Nomoto, Aika Miya, Chiho Yamamoto, Atsushi Inoue, Kenichi Tsuchida, Naoki Manda, Yoshio Kurihara, Shin Aoki, Akinobu Nakamura, Tatsuya Atsumi
  Cardiovascular Diabetology.2017;[Epub]     CrossRef
• Recent Advances in Effect‐directed Enzyme Assays based on Thin‐layer Chromatography
  Sarah Bräm, Evelyn Wolfram
  Phytochemical Analysis.2017; 28(2): 74.     CrossRef
• Efficacy and safety of gemigliptin, a dipeptidyl peptidase‐4 inhibitor, in patients with type 2 diabetes mellitus inadequately controlled with combination treatment of metformin and sulphonylurea: a 24‐week, multicentre, randomized, double‐blind, placebo‐
  Chang Ho Ahn, Kyung Ah Han, Jae Myung Yu, Joo Young Nam, Kyu Jeung Ahn, Tae Keun Oh, Hyoung Woo Lee, Dae Ho Lee, Jaetaek Kim, Choon Hee Chung, Tae Sun Park, Byung Joon Kim, Seok Won Park, Hyeong Kyu Park, Kwang Jae Lee, Sang‐Wook Kim, Jeong Hyun Park, Kwa
  Diabetes, Obesity and Metabolism.2017; 19(5): 635.     CrossRef
• Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association
  Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
  The Korean Journal of Internal Medicine.2017; 32(6): 947.     CrossRef
• Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association
  Seung-Hyun Ko, Kyu-Yeon Hur, Sang Youl Rhee, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Hyun Jin Kim, Kyung Mook Choi, Jin Hwa Kim
  Diabetes & Metabolism Journal.2017; 41(5): 337.     CrossRef
• DPP-4 inhibitors in diabetic complications: role of DPP-4 beyond glucose control
  Eun Ju Bae
  Archives of Pharmacal Research.2016; 39(8): 1114.     CrossRef
• Liraglutide Enhances the Efficacy of Human Mesenchymal Stem Cells in Preserving Islet ß-cell Function in Severe Non-obese Diabetic Mice
  Li-rong Li, Jing Lu, Xiao-lei Jia, Hui Hui, Jie Zhang, Ying Liu, Wei-juan Cui, Qian-yue Xu, Da-long Zhu
  Molecular Medicine.2016; 22(1): 800.     CrossRef

Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine that has various functions in both neuronal and non-neuronal systems. In the central nervous system, 5-HT regulates mood and feeding behaviors as a neurotransmitter. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. Unfortunately, some drugs were withdrawn due to the development of unwanted peripheral side effects, such as valvular heart disease and pulmonary hypertension. Recent studies revealed that peripheral 5-HT plays an important role in metabolic regulation in peripheral tissues, where it suppresses adaptive thermogenesis in brown adipose tissue. Inhibition of 5-HT synthesis reduced the weight gain and improved the metabolic dysfunction in a diet-induced obesity mouse model. Genome-wide association studies also revealed genetic associations between the serotonergic system and obesity. Several genetic polymorphisms in tryptophan hydroxylase and 5-HT receptors were shown to have strong associations with obesity. These results support the clinical significance of the peripheral serotonergic system as a therapeutic target for obesity and diabetes.

Citations

Citations to this article as recorded by  

• Methylation of serotonin regulating genes in cord blood cells: association with maternal metabolic parameters and correlation with methylation in peripheral blood cells during childhood and adolescence
  Ivona Bečeheli, Marina Horvatiček, Maja Perić, Barbara Nikolić, Cyrielle Holuka, Marija Klasić, Marina Ivanišević, Mirta Starčević, Gernot Desoye, Dubravka Hranilović, Jonathan D. Turner, Jasminka Štefulj
  Clinical Epigenetics.2024;[Epub]     CrossRef
• Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway
  Nevertyty M. Mahmoud, Shimaa M. Elshazly, Arwa A. Hassan, Eman Soliman
  International Immunopharmacology.2023; 115: 109646.     CrossRef
• Branched Chain Amino Acids, New Target of Germinated Brown Rice against Type 2 Diabetes Mellitus: A Randomized Controlled Trial
  Wenting Wan, Xianchen Jiang, Ruifang Zhao, Fenfen Cai, Fan Wu, Yunqi Hu, Xiaoqin Zhou, Zhipeng Liu, Yujuan Shan
  Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
• Metabolic and Molecular Response to High-Fat Diet Differs between Rats with Constitutionally High and Low Serotonin Tone
  Petra Baković, Maja Kesić, Darko Kolarić, Jasminka Štefulj, Lipa Čičin-Šain
  International Journal of Molecular Sciences.2023; 24(3): 2169.     CrossRef
• Consumo de Frutose Altera Aminas Biogênicas Associadas a Fatores de Risco Cardiovasculares
  Fabiane Valentini Francisqueti-Ferron, Matheus Antônio Filiol Belin, Thiago Luiz Novaga Palacio, Artur Junio Togneri Ferron, Jéssica Leite Garcia, Juliana Silva Siqueira, Erika Tiemi Nakandakare-Maia, Taynara Aparecida Vieira, Hugo Tadashi Kano, Fernando
  Arquivos Brasileiros de Cardiologia.2023;[Epub]     CrossRef
• Constitutive Serotonin Tone as a Modulator of Brown Adipose Tissue Thermogenesis: A Rat Study
  Maja Kesić, Petra Baković, Vladimir Farkaš, Robert Bagarić, Darko Kolarić, Jasminka Štefulj, Lipa Čičin-Šain
  Life.2023; 13(7): 1436.     CrossRef
• Serotonergic regulation of appetite and sodium appetite
  Yurim Shin, Seungjik Kim, Jong‐Woo Sohn
  Journal of Neuroendocrinology.2023;[Epub]     CrossRef
• Epstein–Barr virus-acquired immunodeficiency in myalgic encephalomyelitis—Is it present in long COVID?
  Manuel Ruiz-Pablos, Bruno Paiva, Aintzane Zabaleta
  Journal of Translational Medicine.2023;[Epub]     CrossRef
• Targeting the Gut in Obesity: Signals from the Inner Surface
  Natalia Petersen, Thomas U. Greiner, Lola Torz, Angie Bookout, Marina Kjærgaard Gerstenberg, Carlos M. Castorena, Rune Ehrenreich Kuhre
  Metabolites.2022; 12(1): 39.     CrossRef
• Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach
  Hussein Kadhem Al-Hakeim, Hadi Hasan Hadi, Ghoufran Akeel Jawad, Michael Maes
  Journal of Personalized Medicine.2022; 12(1): 23.     CrossRef
• Tryptophan Metabolism in Atherosclerosis and Diabetes
  Emina Sudar-Milovanovic, Zoran Gluvic, Milan Obradovic, Bozidarka Zaric, Esma R. Isenovic
  Current Medicinal Chemistry.2022; 29(1): 99.     CrossRef
• The Temporal Profile of Circulating miRNAs during Gestation in Overweight and Obese Women with or without Gestational Diabetes Mellitus
  Anja Elaine Sørensen, Mireille N. M. van Poppel, Gernot Desoye, David Simmons, Peter Damm, Dorte Møller Jensen, Louise Torp Dalgaard
  Biomedicines.2022; 10(2): 482.     CrossRef
• Comparative effectiveness of Hypericum perforatum, acupuncture, and lifestyle modification in the management of obesity: A randomized clinical trial
  Monirsadat Sahebkar-Khorasani, Mohammad Safarian, Lida Jarahi, Mahdi Yousefi, Roshanak Salari, Mojtaba Meshkat, Mohammad Hossein Ayati, Hamidreza Bahrami-Taghanaki, Raheleh Kargozar, Hoda Azizi
  European Journal of Integrative Medicine.2022; 52: 102119.     CrossRef
• Research Progresses for 5-Hydroxytryptamine in Lipid Metabolism
  钰婷 吴
  Bioprocess.2022; 12(01): 1.     CrossRef
• Fast and Sensitive Quantification of AccQ-Tag Derivatized Amino Acids and Biogenic Amines by UHPLC-UV Analysis from Complex Biological Samples
  Andrea Guba, Orsolya Bába, József Tőzsér, Éva Csősz, Gergő Kalló
  Metabolites.2022; 12(3): 272.     CrossRef
• Chronic Treatment With Psilocybin Decreases Changes in Body Weight in a Rodent Model of Obesity
  Joyce Huang, Michelle Pham, William J. Panenka, William G. Honer, Alasdair M. Barr
  Frontiers in Psychiatry.2022;[Epub]     CrossRef
• Antidepressants for depressed patients with type 2 diabetes mellitus: A systematic review and network meta-analysis of short-term randomized controlled trials
  Manit Srisurapanont, Sirijit Suttajit, Natapong Kosachunhanun, Surinporn Likhitsathian, Chawisa Suradom, Benchalak Maneeton
  Neuroscience & Biobehavioral Reviews.2022; 139: 104731.     CrossRef
• Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease
  Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jin Hee Ahn
  European Journal of Medicinal Chemistry.2022; 239: 114517.     CrossRef
• The serotonergic system dysfunction in diabetes mellitus
  Yan Cai, Xiaolong Li, Hongli Zhou, Jiyin Zhou
  Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
• A Comprehensive Review on Anti-obesity Potential of Medicinal Plants and their Bioactive Compounds
  Piyush Verma, Bhuwan Chandra Joshi, Partha Sarathi Bairy
  Current Traditional Medicine.2022;[Epub]     CrossRef
• Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease
  Eun Jung Bae, Won Gun Choi, Haushabhau S. Pagire, Suvarna H. Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn
  Journal of Medicinal Chemistry.2021; 64(2): 1037.     CrossRef
• Serotonin level as a potent diabetes biomarker based on electrochemical sensing: a new approach in a zebra fish model
  Kamyar Khoshnevisan, Hadi Baharifar, Farzad Torabi, Mahsa Sadeghi Afjeh, Hassan Maleki, Elham Honarvarfard, Hassan Mohammadi, Sayed Mahmoud Sajjadi-Jazi, Sadegh Mahmoudi-Kohan, Farnoush Faridbod, Bagher Larijani, Farshid Saadat, Reza Faridi Majidi, Mohamm
  Analytical and Bioanalytical Chemistry.2021; 413(6): 1615.     CrossRef
• Serotonin, food intake, and obesity
  Katy A. van Galen, Kasper W. ter Horst, Mireille J. Serlie
  Obesity Reviews.2021;[Epub]     CrossRef
• Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice
  Luciano N. de Sousa, Débora S. Paraguassú Sant'ana, Rildo G. Siqueira dos Santos, Anita Eugênia A. dos Santos Ribeiro, Camila F. da Costa, Ana Paula de Oliveira, Jackson Roberto G. da Silva Almeida, Davi M. Jucá, Moisés Tolentino Bento da Silva, Armênio A
  Current Research in Pharmacology and Drug Discovery.2021; 2: 100018.     CrossRef
• An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease
  Xiaolan Li, Zhi‐Hong Zhang, Hossain M. Zabed, Junhua Yun, Guoyan Zhang, Xianghui Qi
  Molecular Nutrition & Food Research.2021;[Epub]     CrossRef
• A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis
  Suhyeon Park, Yumin Kim, Jibeom Lee, Jeong Yun Lee, Hail Kim, Sunjae Lee, Chang-Myung Oh
  International Journal of Molecular Sciences.2021; 22(5): 2452.     CrossRef
• Loss of Znt8 function in diabetes mellitus: risk or benefit?
  Carla P. Barragán-Álvarez, Eduardo Padilla-Camberos, Nestor F. Díaz, Agustín Cota-Coronado, Claudia Hernández-Jiménez, Carlos C. Bravo-Reyna, Nestor E. Díaz-Martínez
  Molecular and Cellular Biochemistry.2021; 476(7): 2703.     CrossRef
• Consolidation of network and experimental pharmacology to divulge the antidiabetic action of Ficus benghalensis L. bark
  Pukar Khanal, B. M. Patil
  3 Biotech.2021;[Epub]     CrossRef
• A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes
  Chun-Feng Huang, Ann Chen, Siao-Yun Lin, Mei-Ling Cheng, Ming-Shi Shiao, Tso-Yen Mao
  Saudi Journal of Biological Sciences.2021; 28(8): 4762.     CrossRef
• Metabolic Disturbances in Rat Sublines with Constitutionally Altered Serotonin Homeostasis
  Maja Kesić, Petra Baković, Ranko Stojković, Jasminka Štefulj, Lipa Čičin-Šain
  International Journal of Molecular Sciences.2021; 22(10): 5400.     CrossRef
• The effects of 5-hydroxytryptophan on carrageenan-induced mouse paw oedemas
  Gokçen TELLI, Inci KAZKAYASI, Serdar UMA
  Revista de Nutrição.2021;[Epub]     CrossRef
• Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses
  Helen Irving, Ilona Turek, Christine Kettle, Nor Yaakob
  International Journal of Molecular Sciences.2021; 22(21): 11910.     CrossRef
• Serotonergic Regulation of Hepatic Energy Metabolism
  Jiwon Park, Wooju Jeong, Chahyeon Yun, Hail Kim, Chang-Myung Oh
  Endocrinology and Metabolism.2021; 36(6): 1151.     CrossRef
• Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease
  Minhee Kim, Inseon Hwang, Haushabhau S. Pagire, Suvarna H. Pagire, Wonsuk Choi, Won Gun Choi, Jihyeon Yoon, Won Mi Lee, Jin Sook Song, Eun Kyung Yoo, Seung Mi Lee, Mi-jin Kim, Myung Ae Bae, Dooseop Kim, Heejong Lee, Eun-Young Lee, Jae-Han Jeon, In-Kyu Lee
  Journal of Medicinal Chemistry.2020; 63(8): 4171.     CrossRef
• Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis
  Maja Kesić, Petra Baković, Marina Horvatiček, Bastien Lucien Jean Proust, Jasminka Štefulj, Lipa Čičin-Šain
  Frontiers in Neuroscience.2020;[Epub]     CrossRef
• Appetite and weight control by Hypericum perforatum and acupuncture added to lifestyle modification: Study protocol for a randomized clinical trial
  Monirsadat Sahebkar-Khorasani, Mohammad Safarian, Lida Jarahi, Mahdi Yousefi, Roshanak Salari, Hoda Azizi
  Advances in Integrative Medicine.2020; 7(2): 101.     CrossRef
• Update on the genetic and epigenetic etiology of gestational diabetes mellitus: a review
  Tajudeen O. Yahaya, Titilola Salisu, Yusuf B. Abdulrahman, Abdulrazak K. Umar
  Egyptian Journal of Medical Human Genetics.2020;[Epub]     CrossRef
• Paraben Exposure Related To Purine Metabolism and Other Pathways Revealed by Mass Spectrometry-Based Metabolomics
  Hongzhi Zhao, Yuanyuan Zheng, Lin Zhu, Li Xiang, Yanqiu Zhou, Jiufeng Li, Jing Fang, Shunqing Xu, Wei Xia, Zongwei Cai
  Environmental Science & Technology.2020; 54(6): 3447.     CrossRef
• An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model
  Tugba Gurpinar Çavuşoğlu, Ertan Darıverenli, Kamil Vural, Nuran Ekerbicer, Cevval Ulman, Ercüment Ölmez, Nazan Uysal
  Turkish Journal of Biochemistry.2020; 45(4): 397.     CrossRef
• Pomegranate Metabolites Impact Tryptophan Metabolism in Humans and Mice
  Jieping Yang, Yuanqiang Guo, Rupo Lee, Susanne M Henning, Jing Wang, Yajing Pan, Tianyu Qing, Mark Hsu, Alex Nguyen, Siddarth Prabha, Rashi Ojha, Gary W Small, David Heber, Zhaoping Li
  Current Developments in Nutrition.2020; 4(11): nzaa165.     CrossRef
• Network pharmacology-based assessment to elucidate the molecular mechanism of anti-diabetic action of Tinospora cordifolia
  Pukar Khanal, B. M. Patil, Bijendra K. Mandar, Yadu Nandan Dey, Taaza Duyu
  Clinical Phytoscience.2019;[Epub]     CrossRef
• The distribution of serotonergic nerve on the hippocampus of the fruit bats (Rousettus amplexicaudatus)
  Vivin Wirawati, Nourrisma D. A. Widiati, Geraldus Gunawan, Golda R. Saragih, Puspa Hening, Hevi Wihadmadyatami
  Veterinary World.2019; 12(9): 1460.     CrossRef
• How important is tryptophan in human health?
  Joanna Kałużna-Czaplińska, Paulina Gątarek, Salvatore Chirumbolo, Max Stanley Chartrand, Geir Bjørklund
  Critical Reviews in Food Science and Nutrition.2019; 59(1): 72.     CrossRef
• Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats
  Tetiana Halenova, Igor Zlatskiy, Anton Syroeshkin, Tatiana Maximova, Tatiana Pleteneva
  Molecules.2019; 25(1): 23.     CrossRef
• Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions
  Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen, Hanne D. Hansen
  EJNMMI Research.2019;[Epub]     CrossRef
• Biological activities of water‐soluble polysaccharides fromOpuntia humifusastem in high‐fat‐diet‐fed mice
  Eun‐In Yang, Chang‐Hyun Lee, Denis Nchang Che, Seon‐Il Jang, Young‐Soo Kim
  Journal of Food Biochemistry.2019; 43(4): e12806.     CrossRef
• Countering the Modern Metabolic Disease Rampage With Ancestral Endocannabinoid System Alignment
  Ian Pepper, Aaron Vinik, Frank Lattanzio, William McPheat, Anca Dobrian
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• The regulation of insulin secretion via phosphoinositide-specific phospholipase Cβ signaling
  Hyeon-Jeong Hwang, Hyun-Jun Jang, Lucio Cocco, Pann-Ghill Suh
  Advances in Biological Regulation.2019; 71: 10.     CrossRef
• Clostridium ramosum regulates enterochromaffin cell development and serotonin release
  Ana D. Mandić, Anni Woting, Tina Jaenicke, Anika Sander, Wiebke Sabrowski, Ulrike Rolle-Kampcyk, Martin von Bergen, Michael Blaut
  Scientific Reports.2019;[Epub]     CrossRef
• Estrogen – serotonin interaction and its implication on insulin resistance
  Zulvikar Syambani Ulhaq
  Alexandria Journal of Medicine.2019; 55(1): 76.     CrossRef
• Serotonin prevents differentiation into brown adipocytes and induces transdifferentiation into white adipocytes
  S Rozenblit-Susan, N Chapnik, O Froy
  International Journal of Obesity.2018; 42(4): 704.     CrossRef
• Combined brain Fe, Cu, Zn and neurometabolite analysis – a new methodology for unraveling the efficacy of transcranial direct current stimulation (tDCS) in appetite control
  Agata Ziomber, Artur Dawid Surowka, Lucyna Antkiewicz-Michaluk, Irena Romanska, Pawel Wrobel, Magdalena Szczerbowska-Boruchowska
  Metallomics.2018; 10(3): 397.     CrossRef
• The Effect of Antidepressants on Mesenchymal Stem Cell Differentiation
  Jeffrey S. Kruk, Sandra Bermeo, Kristen K. Skarratt, Stephen J. Fuller, Gustavo Duque
  Journal of Bone Metabolism.2018; 25(1): 43.     CrossRef
• Acute anti‐obesity effects of intracerebroventricular 11β‐HSD1 inhibitor administration in diet‐induced obese mice
  M. Seo, S. A. Islam, S.‐S. Moon
  Journal of Neuroendocrinology.2018;[Epub]     CrossRef
• Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications
  Jeffery A. Goldstein, Lisa A. Bastarache, Joshua C. Denny, Dan M. Roden, Jill M. Pulley, David M. Aronoff
  Pharmacological Research.2018; 130: 44.     CrossRef
• Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat
  Xiaowen Han, Mengjun Min, Juan Wang, Zejun Bao, Hongbin Fan, Xinyu Li, Temitope Isaac Adelusi, Xueyan Zhou, Xiaoxing Yin
  Journal of Neuroscience Research.2018; 96(1): 138.     CrossRef
• A randomized controlled trial of lorcaserin and lifestyle counselling for weight loss maintenance: changes in emotion‐ and stress‐related eating, food cravings and appetite
  A. M. Chao, T. A. Wadden, R. L. Pearl, N. Alamuddin, S. M. Leonard, Z. M. Bakizada, E. Pinkasavage, K. A. Gruber, O. A. Walsh, R. I. Berkowitz, N. Alfaris, J. S. Tronieri
  Clinical Obesity.2018; 8(6): 383.     CrossRef
• Lorcaserin and metabolic disease: weight‐loss dependent and independent effects
  H. Bays, C. Perdomo, E. Nikonova, R. Knoth, M. Malhotra
  Obesity Science & Practice.2018; 4(6): 499.     CrossRef
• Rol del sistema serotoninérgico en la diabetes mellitus y sus dianas farmacológicas
  Victor Orozco, Camilo Caicedo
  Revista Médica Sanitas.2018; 21(3): 125.     CrossRef
• Effects of Melatonin Administration in Different Time Modes on Morphofunctional Indices of the Hypothalamic Serotonergic Neurons in Obese Rats
  O. O. Kalmukova, A. V. Yurchenko, V. M. Kyryk, V. M. Nepomnyaschy, O. M. Savchuk, M. E. Dzerzhynsky
  Neurophysiology.2018; 50(6): 398.     CrossRef
• Role of central and peripheral serotonin in obesity: what to expect in the near pharmacotherapy future?
  Mina T Kelleni
  Advances in Obesity, Weight Management & Control.2018;[Epub]     CrossRef
• Elevating serotonin pre-partum alters the Holstein dairy cow hepatic adaptation to lactation
  Samantha R. Weaver, Allan S. Prichard, Noah L. Maerz, Austin P. Prichard, Elizabeth L. Endres, Lorenzo E. Hernández-Castellano, Matthew S. Akins, Rupert M. Bruckmaier, Laura L. Hernandez, Juan J. Loor
  PLOS ONE.2017; 12(9): e0184939.     CrossRef
• Biology of obesity and weight regain
  Mary Madeline Rogge, Bibha Gautam
  Journal of the American Association of Nurse Practitioners.2017; 29(S1): S15.     CrossRef
• 5-HT 2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress
  Minal Jaggar, Noelia Weisstaub, Jay A. Gingrich, Vidita A. Vaidya
  Neurobiology of Stress.2017; 7: 89.     CrossRef
• Serotonergic Control of Metabolic Homeostasis
  Steven C. Wyler, Caleb C. Lord, Syann Lee, Joel K. Elmquist, Chen Liu
  Frontiers in Cellular Neuroscience.2017;[Epub]     CrossRef
• Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
  Yu Yang, Hui Huang, Zheng Xu, Jun-kai Duan
  Journal of Diabetes Research.2017; 2017: 1.     CrossRef
• Bivalent role of intra-platelet serotonin in liver regeneration and tumor recurrence in humans
  Robin Padickakudy, David Pereyra, Florian Offensperger, Philipp Jonas, Lukas Oehlberger, Christian Schwarz, Stefanie Haegele, Alice Assinger, Christine Brostjan, Thomas Gruenberger, Patrick Starlinger
  Journal of Hepatology.2017; 67(6): 1243.     CrossRef
• Factors involved in white‐to‐brown adipose tissue conversion and in thermogenesis: a review
  T. Montanari, N. Pošćić, M. Colitti
  Obesity Reviews.2017; 18(5): 495.     CrossRef
• Cross-Talk Between Insulin Signaling and G Protein–Coupled Receptors
  Qin Fu, Qian Shi, Toni M. West, Yang K. Xiang
  Journal of Cardiovascular Pharmacology.2017; 70(2): 74.     CrossRef
• P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions
  Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B. Komissarov, Franco Venanzi, Sergey I. Kolesnikov, Albert A. Sufianov, Michael Y. Sherman, Vladimir L. Gabai, Alexander M. Shneider
  Oncotarget.2017; 8(34): 56030.     CrossRef
• Regulation of Systemic Energy Homeostasis by Peripheral Serotonin
  Jun Namkung, Chang-Myung Oh, Sangkyu Park, Hail Kim
  Journal of mucopolysaccharidosis and rare disease.2016; 2(2): 43.     CrossRef
• Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells
  Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo
  Cell Reports.2016; 17(12): 3281.     CrossRef

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, host genetics, and gut microbiota leads to excessive accumulation of lipids in the liver (steatosis), which may result in lipotoxicity and trigger hepatocyte cell death, liver inflammation, fibrosis, and pathological angiogenesis. NASH can further progress towards liver cirrhosis and cancer. Over the last few years, cell-derived extracellular vesicles (EVs) have been identified as effective cell-to-cell messengers that transfer several bioactive molecules in target cells, modulating the pathogenesis and progression of NASH. In this review, we focused on recently highlighted aspects of molecular pathogenesis of NASH, mediated by EVs via their bioactive components. The studies included in this review summarize the state of art regarding the role of EVs during the progression of NASH and bring novel insight about the potential use of EVs for diagnosis and therapeutic strategies for patients with this disease.

Citations

Citations to this article as recorded by  

• Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats
  Esra Palabiyik, Ayse Nurseli Sulumer, Handan Uguz, Bahri Avci, Seda Askin, Hakan Askin
  European Journal of Lipid Science and Technology.2024;[Epub]     CrossRef
• Extracellular Vesicles and Their Correlation with Inflammatory Factors in an Experimental Model of Steatotic Liver Disease Associated with Metabolic Dysfunction
  Melina Belén Keingeski, Larisse Longo, Vitória Brum da Silva Nunes, Fabrício Figueiró, Danieli Rosane Dallemole, Adriana Raffin Pohlmann, Thalia Michele Vier Schmitz, Patrícia Luciana da Costa Lopez, Mário Reis Álvares-da-Silva, Carolina Uribe-Cruz
  Metabolic Syndrome and Related Disorders.2024;[Epub]     CrossRef
• β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
  Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail, Mostafa A. Farrag
  BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
• Phospholipid metabolism in the liver – Implications for phosphatidylserine in non-alcoholic fatty liver disease
  Marziyeh Anari, Magdalene K. Montgomery
  Biochemical Pharmacology.2023; 213: 115621.     CrossRef
• Exosome GLUT1 derived from hepatocyte identifies the risk of non-alcoholic steatohepatitis and fibrosis
  Wenyan Zhang, Jing Zhang, Honglin Shi, Fang Liu, Haibin Yu, Hongbo Shi
  Hepatology International.2023; 17(5): 1170.     CrossRef
• Role of extracellular vesicles in nonalcoholic fatty liver disease
  Wei Jiang, Youhui Xu, Jou-Chen Chen, Yi-Hung Lee, Yushin Hu, Chang-Hai Liu, Enqiang Chen, Hong Tang, Hua Zhang, Dongbo Wu
  Frontiers in Endocrinology.2023;[Epub]     CrossRef
• Angiopoietin-2 levels correlates with disease activity in children with nonalcoholic fatty liver disease
  Melania Manco, Nadia Panera, Annalisa Crudele, Maria Rita Braghini, Marzia Bianchi, Donatella Comparcola, Rita De Vito, Giuseppe Maggiore, Anna Alisi
  Pediatric Research.2022; 91(7): 1781.     CrossRef
• The Neglected Role of Bile Duct Epithelial Cells in NASH
  Massimiliano Cadamuro, Alberto Lasagni, Samantha Sarcognato, Maria Guido, Roberto Fabris, Mario Strazzabosco, Alastair J. Strain, Paolo Simioni, Erica Villa, Luca Fabris
  Seminars in Liver Disease.2022; 42(01): 034.     CrossRef
• Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: A systematic review and meta-analysis
  Binjing Pan, Jing Cai, Pingping Zhao, Jingfang Liu, Songbo Fu, Gaojing Jing, Qianglong Niu, Qiong Li
  Osteoporosis International.2022; 33(11): 2275.     CrossRef
• Ethanol Extract of Pinus koraiensis Leaves Mitigates High Fructose-Induced Hepatic Triglyceride Accumulation and Hypertriglyceridemia
  Min-Ho Lee, Sunyeong Park, Yinzhu Xu, Jung-Eun Kim, Hengmin Han, Jae-Hyeon Lee, Jean Kyung Paik, Hyo-Jeong Lee
  Applied Sciences.2022; 12(13): 6745.     CrossRef
• TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis
  Yanmei Zhang, Xiaoxiao Ge, Yongqing Li, Bingyang Zhang, Peijun Wang, Mingju Hao, Peng Gao, Yueyi Zhao, Tao Sun, Sumei Lu, Wanshan Ma
  Lipids in Health and Disease.2021;[Epub]     CrossRef
• Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
  In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
  Scientific Reports.2021;[Epub]     CrossRef
• Tabebuia rosea (Bertol.) DC. ethanol extract attenuates body weight gain by activation of molecular mediators associated with browning
  Elsa Cecilia Pagaza-Straffon, Carla Elena Mezo-González, David Armando Chavaro-Pérez, Jorge Cornejo-Garrido, Laurence A. Marchat, Claudia G. Benítez-Cardoza, Maricruz Anaya-Reyes, Cynthia Ordaz-Pichardo
  Journal of Functional Foods.2021; 86: 104740.     CrossRef
• Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
  Zhangya He, Xiaomin Li, Hexiang Yang, Pei Wu, Shanshan Wang, Dan Cao, Xiaoxiao Guo, Zhangrui Xu, Jiayi Gao, Wanyu Zhang, Xiaoqin Luo
  Frontiers in Nutrition.2021;[Epub]     CrossRef
• Hepatic lipid droplet homeostasis and fatty liver disease
  Fabian Seebacher, Anja Zeigerer, Nora Kory, Natalie Krahmer
  Seminars in Cell & Developmental Biology.2020; 108: 72.     CrossRef
• Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
  Johanna Matilainen, Anne-Mari Mustonen, Kirsi Rilla, Reijo Käkelä, Sanna P. Sihvo, Petteri Nieminen
  Lipids in Health and Disease.2020;[Epub]     CrossRef
• Liver fibrogenesis: un update on established and emerging basic concepts
  Erica Novo, Claudia Bocca, Beatrice Foglia, Francesca Protopapa, Marina Maggiora, Maurizio Parola, Stefania Cannito
  Archives of Biochemistry and Biophysics.2020; 689: 108445.     CrossRef
• Relative contribution of fat diet and physical inactivity to the development of metabolic syndrome and non-alcoholic fat liver disease in Wistar rats
  Antonio Bovolini, Juliana Garcia, Maria Amparo Andrade, José Alberto Duarte
  Physiology & Behavior.2020; 225: 113040.     CrossRef
• Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway
  Li Zhang, Hui-Xia Li, Wu-Si Pan, Farhan Ullah Khan, Cheng Qian, Feng-Rong Qi-Li, Xiaojun Xu
  Biomedicine & Pharmacotherapy.2019; 110: 571.     CrossRef
• Association Between Nonalcoholic Fatty Liver Disease and Future Deterioration of Metabolic Health: A Cohort Study
  You‐Cheol Hwang, Hong‐Yup Ahn, Cheol‐Young Park
  Obesity.2019; 27(8): 1360.     CrossRef
• Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer
  Hongbo Wang, Zaiming Lu, Xiangxuan Zhao
  Journal of Hematology & Oncology.2019;[Epub]     CrossRef
• Elastography in the Diagnosis of Non-Alcoholic Fatty Liver Disease
  Elena N. Shirokova, Chavdar S. Pavlov, Anna D. Karaseva, Aliya M. Alieva, Alla V. Sedova, Vladimir T. Ivashkin
  Annals of the Russian academy of medical sciences.2019; 74(1): 5.     CrossRef
• Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro
  Xiao-qun Han, San-qing Xu, Jian-guo Lin
  Current Medical Science.2019; 39(5): 766.     CrossRef
• Lipid mediators of liver injury in nonalcoholic fatty liver disease
  Suthat Liangpunsakul, Naga Chalasani
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 316(1): G75.     CrossRef
• Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
  Maurizio Parola, Massimo Pinzani
  Molecular Aspects of Medicine.2019; 65: 37.     CrossRef
• Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis
  Lili Nimri, Katerina Staikin, Irena Peri, Einav Yehuda‐Shnaidman, Betty Schwartz
  Journal of Gastroenterology and Hepatology.2018; 33(12): 1990.     CrossRef
• miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
  Chang-Hai Liu, Javier Ampuero, Antonio Gil-Gómez, Rocío Montero-Vallejo, Ángela Rojas, Rocío Muñoz-Hernández, Rocío Gallego-Durán, Manuel Romero-Gómez
  Journal of Hepatology.2018; 69(6): 1335.     CrossRef
• Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells
  Jae Min Cha, Eun Kyoung Shin, Ji Hee Sung, Gyeong Joon Moon, Eun Hee Kim, Yeon Hee Cho, Hyung Dal Park, Hojae Bae, Jinseok Kim, Oh Young Bang
  Scientific Reports.2018;[Epub]     CrossRef
• Changes in the Structure of the Liver during Obesity (Literature Review)
  V. I. Prymachenko
  Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 4(2): 45.     CrossRef
• Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease
  Juan Pablo Arab, Marco Arrese, Michael Trauner
  Annual Review of Pathology: Mechanisms of Disease.2018; 13(1): 321.     CrossRef
• Apoptosis and non-alcoholic fatty liver diseases
  Tatsuo Kanda, Shunichi Matsuoka, Motomi Yamazaki, Toshikatsu Shibata, Kazushige Nirei, Hiroshi Takahashi, Tomohiro Kaneko, Mariko Fujisawa, Teruhisa Higuchi, Hitomi Nakamura, Naoki Matsumoto, Hiroaki Yamagami, Masahiro Ogawa, Hiroo Imazu, Kazumichi Kuroda
  World Journal of Gastroenterology.2018; 24(25): 2661.     CrossRef
• Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: a novel gut-immune system-based therapy for metaflammation and NASH
  Y Ilan, K Shailubhai, A Sanyal
  Clinical and Experimental Immunology.2018; 193(3): 275.     CrossRef
• Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice
  Karla Frida Torres Flister, Bruno Araújo Serra Pinto, Lucas Martins França, Caio Fernando Ferreira Coêlho, Pâmela Costa dos Santos, Caroline Castro Vale, Daniela Kajihara, Victor Debbas, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Paes
  The Journal of Nutritional Biochemistry.2018; 62: 155.     CrossRef
• Blood-based novel biomarkers for nonalcoholic steatohepatitis
  Yun Qiu, Sufan Wang, Ting Wan, Mingtong Ye, Rui Jiang, Lei Pei, Lili Yang
  Biomarkers in Medicine.2018; 12(5): 501.     CrossRef
• The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
  Bojan Jorgačević, Danijela Vučević, Ivana Đuričić, Slađana Šobajić, Dušan Mladenović, Milena Vesković, Rada Ješić Vukićević, Tatjana Radosavljević
  Chemistry and Physics of Lipids.2017; 204: 85.     CrossRef
• Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition
  Soo Hyun Kim, Gyuri Kim, Dai Hoon Han, Milim Lee, Irene Kim, Bohkyung Kim, Kook Hwan Kim, Young-Mi Song, Jeong Eun Yoo, Hye Jin Wang, Soo Han Bae, Yong-Ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Myung-Shik Lee
  Autophagy.2017; 13(10): 1767.     CrossRef
• Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status
  Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Seung Hwan Han, Kwang-Hyub Han, Bong-Soo Cha, Choon Hee Chung, Byung-Wan Lee
  Metabolism.2017; 66: 23.     CrossRef
• Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease
  Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim, Salvatore Petta
  PLOS ONE.2017; 12(7): e0182202.     CrossRef
• Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation
  Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Susanne Kaser
  PLOS ONE.2017; 12(7): e0180118.     CrossRef
• Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats
  Xu-Jia Chen, Wen-Jing Liu, Meng-Liang Wen, Hong Liang, Shao-Mei Wu, Yun-Zhen Zhu, Jiang-Yuan Zhao, Xiang-Qian Dong, Ming-Gang Li, Li Bian, Cheng-Gang Zou, Lan-Qing Ma
  Scientific Reports.2017;[Epub]     CrossRef
• Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH
  Melanie Tran, Sang-Min Lee, Dong-Ju Shin, Li Wang
  JCI Insight.2017;[Epub]     CrossRef
• Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis
  Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic, Miodrag L Lukic
  World Journal of Gastroenterology.2016; 22(44): 9706.     CrossRef
• Hepatocyte mitochondrial DNA released in microparticles and toll‐like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis
  Maria Eugenia Inzaugarat, Alexander Wree, Ariel E. Feldstein
  Hepatology.2016; 64(2): 669.     CrossRef
• Metabolic aspects of adult patients with nonalcoholic fatty liver disease
  Ludovico Abenavoli, Natasa Milic, Laura Di Renzo, Tomislav Preveden, Milica Medić-Stojanoska, Antonino De Lorenzo
  World Journal of Gastroenterology.2016; 22(31): 7006.     CrossRef
• Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions
  Maria Grazia Clemente, Claudia Mandato, Marco Poeta, Pietro Vajro
  World Journal of Gastroenterology.2016; 22(36): 8078.     CrossRef
• Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals
  Sabri Rial, Antony Karelis, Karl-F. Bergeron, Catherine Mounier
  Nutrients.2016; 8(5): 281.     CrossRef

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects against atherosclerosis. Circulating levels of FGF21 are elevated in patients with atherosclerosis, macrovascular and microvascular complications of diabetes, possibly due to a compensatory upregulation. In apolipoprotein E-deficient mice, formation of atherosclerotic plaques is exacerbated by genetic depletion of FGF21, but is attenuated upon replenishment with recombinant FGF21. However, the blood vessel is not the direct target of FGF21, and the antiatherosclerotic activity of FGF21 is attributed to its actions in adipose tissues and liver. In adipocytes, FGF21 promotes secretion of adiponectin, which in turn acts directly on blood vessels to reduce endothelial dysfunction, inhibit proliferation of smooth muscle cells and block conversion of macrophages to foam cells. Furthermore, FGF21 suppresses cholesterol biosynthesis and attenuates hypercholesterolemia by inhibiting the transcription factor sterol regulatory element-binding protein-2 in hepatocytes. The effects of FGF21 on elevation of adiponectin and reduction of hypercholesterolemia are also observed in a phase-1b clinical trial in patients with obesity and diabetes. Therefore, FGF21 exerts its protection against atherosclerosis by fine-tuning the interorgan crosstalk between liver, brain, adipose tissue, and blood vessels.

Citations

Citations to this article as recorded by  

• Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications
  Leigang Jin, Ranyao Yang, Leiluo Geng, Aimin Xu
  Annual Review of Pharmacology and Toxicology.2023; 63(1): 359.     CrossRef
• Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH)
  Tobias Puengel, Frank Tacke
  Expert Opinion on Investigational Drugs.2023; 32(6): 451.     CrossRef
• The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease
  Meichao Cai, Dongsheng Zhao, Xiao Han, Shuang Han, Wenxin Zhang, Zhennan Zang, Chenchen Gai, Rong Rong, Tian Gao
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
  Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
  Cardiovascular Research.2022; 118(2): 489.     CrossRef
• Relationship between Serum FGF21 and vWF Expression and Carotid Atherosclerosis in Elderly Patients with Hypertension
  Jing Bian, Lairong Chen, Qin Li, Yunfeng Zhao, Delu Yin, Shanhong Sun, Bhagyaveni M.A
  Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
• Serum FGF21 Levels Predict the MACE in Patients With Myocardial Infarction After Coronary Artery Bypass Graft Surgery
  Wei Xie, Dan Li, Yaru Shi, Ning Yu, Yu Yan, Yingchao Zhang, Qiongli Yu, Yulin Li, Jie Du, Zhuofeng Lin, Fan Wu
  Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
• Adipokines, adiposity, and atherosclerosis
  Longhua Liu, Zunhan Shi, Xiaohui Ji, Wenqian Zhang, Jinwen Luan, Tarik Zahr, Li Qiang
  Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
• Current understanding and controversies on the clinical implications of fibroblast growth factor 21
  Yasaman Badakhshi, Tianru Jin
  Critical Reviews in Clinical Laboratory Sciences.2021; 58(5): 311.     CrossRef
• The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development
  Ting Xie, Liangying Yin, Dan Guo, Zixin Zhang, Yuexin Chen, Bao Liu, Wei Wang, Yuehong Zheng
  Life Sciences.2021; 274: 119346.     CrossRef
• Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy
  Jiameng Gao, Jingjing Liu, Zheying Meng, Yanming Li, Yuping Hong, Lirui Wang, Lan He, Bing Hu, Yuanyi Zheng, Tianliang Li, Daxiang Cui, E. Shen
  Acta Biomaterialia.2021; 130: 395.     CrossRef
• Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model
  Hyo Jin Maeng, Gha Young Lee, Jae Hyun Bae, Soo Lim
  International Journal of Molecular Sciences.2020; 21(18): 6836.     CrossRef
• The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
  Leiluo Geng, Karen S. L. Lam, Aimin Xu
  Nature Reviews Endocrinology.2020; 16(11): 654.     CrossRef
• Two-hundred-liter scale fermentation, purification of recombinant human fibroblast growth factor-21, and its anti-diabetic effects on ob/ob mice
  Qi Hui, Zhen Huang, Shucai Pang, Xuanxin Yang, Jinghang Li, Bingjie Yu, Lu Tang, Xiaokun Li, Xiaojie Wang
  Applied Microbiology and Biotechnology.2019; 103(2): 719.     CrossRef
• Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?
  Niki Katsiki, Christos Mantzoros
  Metabolism.2019; 93: iii.     CrossRef
• Heparin‐poloxamer hydrogel‐encapsulated rhFGF21 enhances wound healing in diabetic mice
  Huan Liu, Yeli Zhao, Yuchi Zou, Wenting Huang, Liyun Zhu, Fei Liu, Dongxue Wang, Kaiming Guo, Jian Hu, Jun Chen, Lixia Ye, Xiaokun Li, Li Lin
  The FASEB Journal.2019; 33(9): 9858.     CrossRef
• Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes
  Saeed Yafei, Fathy Elsewy, Eman Youssef, Mohammed Ayman, Mohamed El-Shafei
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 882.     CrossRef
• Myokines in metabolic homeostasis and diabetes
  Jürgen Eckel
  Diabetologia.2019; 62(9): 1523.     CrossRef
• Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
  Wei Wei, Xiao-Xue Li, Ming Xu
  Atherosclerosis.2019; 289: 132.     CrossRef
• LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
  Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho, Partha Mukhopadhyay
  PLOS ONE.2018; 13(2): e0192146.     CrossRef
• Relationship of Selected Adipokines with Markers of Vascular Damage in Patients with Type 2 Diabetes
  Jaromíra Spurná, David Karásek, Veronika Kubíčková, Dominika Goldmannová, Ondřej Krystyník, Jan Schovánek, Josef Zadražil
  Metabolic Syndrome and Related Disorders.2018; 16(5): 246.     CrossRef
• Serum FGF21 Is Associated with Future Cardiovascular Events in Patients with Coronary Artery Disease
  Yun Shen, Xueli Zhang, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
  Cardiology.2018; 139(4): 212.     CrossRef
• Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
  Sung Don Park, Kwi-Hyun Bae, Yeon-Kyung Choi, Jae-Han Jeon, Jung Beom Seo, Namkyun Kim, Chang-Yeon Kim, Sung Woo Kim, Won Kee Lee, Jung Guk Kim, In-Kyu Lee, Jang Hoon Lee, Keun-Gyu Park
  Journal of Lipid and Atherosclerosis.2018; 7(1): 42.     CrossRef
• Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages
  Nan Wang, Jun-yan Li, Shuai Li, Xiao-chen Guo, Tong Wu, Wen-fei Wang, De-shan Li
  Biomedicine & Pharmacotherapy.2018; 108: 1825.     CrossRef
• Chip‐based high resolution tandem mass spectrometric determination of fibroblast growth factor—chondroitin sulfate disaccharides noncovalent interaction
  Adrian C. Robu, Laurentiu Popescu, Daniela G. Seidler, Alina D. Zamfir
  Journal of Mass Spectrometry.2018; 53(7): 624.     CrossRef
• Conditioned medium from contracting skeletal muscle cells reverses insulin resistance and dysfunction of endothelial cells
  Yihe Zhao, Nana Li, Zhu Li, Da Zhang, Liming Chen, Zhi Yao, Wenyan Niu
  Metabolism.2018; 82: 36.     CrossRef
• Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
  Stefanie Worsch, Mathias Heikenwalder, Hans Hauner, Bernhard L. Bader
  Nutrition & Metabolism.2018;[Epub]     CrossRef
• Metabolic Values of Fibroblasts Growth Factor 21 in Patients with Coronary Artery Disease and Obesity
  L. M. Pasiyeshvili, K. V. Ivanova
  Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 3(4): 110.     CrossRef
• FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
  Antero Salminen, Anu Kauppinen, Kai Kaarniranta
  Journal of Molecular Medicine.2017; 95(2): 123.     CrossRef
• Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
  Antero Salminen, Kai Kaarniranta, Anu Kauppinen
  Ageing Research Reviews.2017; 37: 79.     CrossRef
• Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death
  Yun Shen, Xueli Zhang, Xiaoping Pan, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
  Cardiovascular Diabetology.2017;[Epub]     CrossRef
• Fibroblast growth factor 21 – a key player in cardiovascular disorders?
  Monika Lenart-Lipińska, Dariusz Duma, Magdalena Hałabiś, Marcin Dziedzic, Janusz Solski
  Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
• The role of fibroblast growth factor 21 in atherosclerosis
  John Kokkinos, Shudi Tang, Kerry-Anne Rye, Kwok Leung Ong
  Atherosclerosis.2017; 257: 259.     CrossRef

Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.

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Citations to this article as recorded by  

• Modulation of angiogenic switch in reprogramming browning and lipid metabolism in white adipocytes
  Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2024; 1869(1): 159423.     CrossRef
• Anti-Obesity Effects of GABA in C57BL/6J Mice with High-Fat Diet-Induced Obesity and 3T3-L1 Adipocytes
  Heegu Jin, Hyein Han, Gunju Song, Hyun-Ji Oh, Boo-Yong Lee
  International Journal of Molecular Sciences.2024; 25(2): 995.     CrossRef
• Citrus aurantium L. and synephrine improve brown adipose tissue function in adolescent mice programmed by early postnatal overfeeding
  Andressa Cardoso Guimarães, Egberto Gaspar de Moura, Stephanie Giannini Silva, Bruna Pereira Lopes, Iala Milene Bertasso, Carla Bruna Pietrobon, Fernanda Torres Quitete, Tayanne de Oliveira Malafaia, Érica Patrícia Garcia Souza, Patrícia Cristina Lisboa,
  Frontiers in Nutrition.2024;[Epub]     CrossRef
• Au@16-pH-16/miR-21 mimic nanosystem: An efficient treatment for obesity through browning and thermogenesis induction
  Said Lhamyani, Adriana-Mariel Gentile, María Mengual-Mesa, Elia Grueso, Rosa M. Giráldez-Pérez, José Carlos Fernandez-Garcia, Antonio Vega-Rioja, Mercedes Clemente-Postigo, John R. Pearson, Isabel González-Mariscal, Gabriel Olveira, Francisco-Javier Bermu
  Biomedicine & Pharmacotherapy.2024; 171: 116104.     CrossRef
• Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type
  Tamara Dakic, Dusan Jeremic, Iva Lakic, Nebojsa Jasnic, Aleksandra Ruzicic, Predrag Vujovic, Tanja Jevdjovic
  Molecular and Cellular Biochemistry.2024;[Epub]     CrossRef
• A Newly Synbiotic Combination Alleviates Obesity by Modulating the Gut Microbiota–Fat Axis and Inhibiting the Hepatic TLR4/NF‐κB Signaling Pathway
  Yongbo Kang, Peng Ren, Xiaorong Shen, Xiaoyu Kuang, Xiaodan Yang, Haixia Liu, Huan Yan, Hao Yang, Xing Kang, Zeyuan Ding, Xuguang Luo, Jieqiong Ma, Ying Yang, Weiping Fan
  Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
• Lacticaseibacillus paracasei AO356 ameliorates obesity by regulating adipogenesis and thermogenesis in C57BL/6J male mice
  Young In Kim, Eun-Sook Lee, Eun-Ji Song, Dong-Uk Shin, Ji-Eun Eom, Hee Soon Shin, Jung Eun Kim, Ju Yeoun Oh, Young-Do Nam, So-Young Lee
  Journal of Functional Foods.2023; 101: 105404.     CrossRef
• Effects of caffeoylquinic acid analogs derived from aerial parts of Artemisia iwayomogi on adipogenesis
  Su-Young Han, Jisu Kim, Bo Kyeong Kim, Wan Kyunn Whang, Hyeyoung Min
  Food Science and Biotechnology.2023; 32(9): 1215.     CrossRef
• Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
  Mi Jin Choi, Hana Yu, Jea Il Kim, Hee Seo, Ju Gyeong Kim, Seul-Ki Kim, Hak Sung Lee, Hyae Gyeong Cheon
  European Journal of Nutrition.2023; 62(4): 1611.     CrossRef
• Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome
  Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani
  Laboratory Medicine.2023; 54(5): 457.     CrossRef
• A Novel Mix of Polyphenols and Micronutrients Reduces Adipogenesis and Promotes White Adipose Tissue Browning via UCP1 Expression and AMPK Activation
  Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di D
  Cells.2023; 12(5): 714.     CrossRef
• Thromboxane A2-TP axis promotes adipose tissue macrophages M1 polarization leading to insulin resistance in obesity
  Ruijie Xu, Yufeng Dai, Xu Zheng, Yongheng Yan, Zhao He, Hao Zhang, Haitao Li, Wei Chen
  Biochemical Pharmacology.2023; 210: 115465.     CrossRef
• Green Tea Epigallocatechin Gallate Inhibits Preadipocyte Growth via the microRNA‐let‐7a/HMGA2 Signaling Pathway
  Wen‐Ting Chen, Meei‐Ju Yang, Yi‐Wei Tsuei, Tsung‐Chen Su, An‐Ci Siao, Yow‐Chii Kuo, Ling‐Ru Huang, Yi Chen, Sy‐Jou Chen, Po‐Chuan Chen, Ching‐Feng Cheng, Hui‐Chen Ku, Yung‐Hsi Kao
  Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
• Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment
  Rui-Chian Tang, I-Hsuan Yang, Feng-Huei Lin
  Biomacromolecules.2023; 24(8): 3438.     CrossRef
• Short-duration cold exposure decreases fasting-induced glucose intolerance but has no effect on resting energy expenditure
  Rima Solianik, Katerina Židonienė, Marius Brazaitis
  Cryobiology.2023; 113: 104564.     CrossRef
• Caffeine promotes the production of Irisin in muscles and thus facilitates the browning of white adipose tissue
  Chang Liu, Yi Li, Ge Song, Xuehan Li, Songyue Chen, Dixin Zou, Huixin Li, Chengyi Hu, Haotian Zhao, Yi Yan
  Journal of Functional Foods.2023; 108: 105702.     CrossRef
• Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment
  Ahmed F. El-Yazbi, Mohamed A. Elrewiny, Hosam M. Habib, Ali H. Eid, Perihan A. Elzahhar, Ahmed S.F. Belal
  Molecular Pharmacology.2023; 104(5): 187.     CrossRef
• Rabbit Meat Extract Induces Browning in 3T3−L1 Adipocytes via the AMP−Activated Protein Kinase Pathway
  In-Seon Bae, Jeong Ah Lee, Soo-Hyun Cho, Hyoun-Wook Kim, Yunseok Kim, Kangmin Seo, Hyun-Woo Cho, Min Young Lee, Ju Lan Chun, Ki Hyun Kim
  Foods.2023; 12(19): 3671.     CrossRef
• Metabolic-Dysfunction-Associated Steatotic Liver Disease—Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Treatments
  Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama
  International Journal of Molecular Sciences.2023; 24(20): 15473.     CrossRef
• Brown Fat and Nutrition: Implications for Nutritional Interventions
  Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
  Nutrients.2023; 15(18): 4072.     CrossRef
• Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases
  Giovanni Martemucci, Giuseppe Fracchiolla, Marilena Muraglia, Roberta Tardugno, Roberta Savina Dibenedetto, Angela Gabriella D’Alessandro
  Antioxidants.2023; 12(12): 2091.     CrossRef
• Metabolic responses of light and taste receptors – unexpected actions of GPCRs in adipocytes
  Onyinye Nuella Ekechukwu, Mark Christian
  Reviews in Endocrine and Metabolic Disorders.2022; 23(1): 111.     CrossRef
• The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
  Hui-Chen Ku, Tsai-Yun Chan, Jia-Fang Chung, Yung-Hsi Kao, Ching-Feng Cheng
  Biomedicine & Pharmacotherapy.2022; 145: 112440.     CrossRef
• Prednisone stimulates white adipocyte browning via β3-AR/p38 MAPK/ERK signaling pathway
  Sulagna Mukherjee, Jong Won Yun
  Life Sciences.2022; 288: 120204.     CrossRef
• Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice
  Qiyang Chen, Dan Wang, Yue Gu, Zixiao Jiang, Zhiqin Zhou
  The Journal of Nutritional Biochemistry.2022; 101: 108943.     CrossRef
• Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management
  Sujeong Mun, Kihyun Park, Siwoo Lee
  EPMA Journal.2022; 13(1): 125.     CrossRef
• Effects of a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Pemafibrate, on Metabolic Parameters: A Retrospective Longitudinal Study
  Hidekatsu Yanai, Hisayuki Katsuyama, Mariko Hakoshima
  Biomedicines.2022; 10(2): 401.     CrossRef
• Historical and cultural aspects of obesity: From a symbol of wealth and prosperity to the epidemic of the 21st century
  Marta Sumińska, Rafał Podgórski, Klaudia Bogusz‐Górna, Bogda Skowrońska, Artur Mazur, Marta Fichna
  Obesity Reviews.2022;[Epub]     CrossRef
• Molecular Biological and Clinical Understanding of the Statin Residual Cardiovascular Disease Risk and Peroxisome Proliferator-Activated Receptor Alpha Agonists and Ezetimibe for Its Treatment
  Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
  International Journal of Molecular Sciences.2022; 23(7): 3418.     CrossRef
• Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice
  Renata Silvério, Robson Barth, Andrea S. Heimann, Patrícia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermúdez-Silva, Alex Rafacho, Emer S. Ferro
  International Journal of Molecular Sciences.2022; 23(8): 4082.     CrossRef
• Thermogenic T cells: a cell therapy for obesity?
  Ulf H. Beier, Daniel J. Baker, Joseph A. Baur
  American Journal of Physiology-Cell Physiology.2022; 322(6): C1085.     CrossRef
• Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
  Maria E. C. Bruno, Sujata Mukherjee, Whitney L. Powell, Stephanie F. Mori, Franklyn K. Wallace, Beverly K. Balasuriya, Leon C. Su, Arnold J. Stromberg, Donald A. Cohen, Marlene E. Starr
  GeroScience.2022; 44(3): 1761.     CrossRef
• Deletion of GPR30 Drives the Activation of Mitochondrial Uncoupling Respiration to Induce Adipose Thermogenesis in Female Mice
  Jing Luo, Yao Wang, Elizabeth Gilbert, Dongmin Liu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes
  Lini Song, Xi Cao, Wenyi Ji, Lili Zhao, Weili Yang, Ming Lu, Jinkui Yang
  European Journal of Pharmacology.2022; 926: 175040.     CrossRef
• TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation
  Huan Ma, Chengkang He, Li Li, Peng Gao, Zongshi Lu, Yingru Hu, Lijuan Wang, Yu Zhao, Tingbing Cao, Yuanting Cui, Hongting Zheng, Gangyi Yang, Zhencheng Yan, Daoyan Liu, Zhiming Zhu
  International Journal of Obesity.2022; 46(8): 1544.     CrossRef
• Adapalene induces adipose browning through the RARβ-p38 MAPK-ATF2 pathway
  Na Hyun Lee, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
  Archives of Pharmacal Research.2022; 45(5): 340.     CrossRef
• Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions
  Francisca M. Acosta, Katerina Stojkova, Jingruo Zhang, Eric Ivan Garcia Huitron, Jean X. Jiang, Christopher R. Rathbone, Eric M. Brey
  Journal of Tissue Engineering.2022; 13: 204173142211093.     CrossRef
• Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway
  Xin Liu, Yuan Huang, Xu Liang, Qiong Wu, Nan Wang, Li-jun Zhou, Wen-wu Liu, Qun Ma, Bei Hu, Huan Gao, Ya-ling Cui, Xiang Li, Qing-chun Zhao
  Phytomedicine.2022; 104: 154289.     CrossRef
• The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall
  Cassie Hillock-Watling, Avrum I. Gotlieb
  Cardiovascular Pathology.2022; 61: 107459.     CrossRef
• RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function
  Pengpeng Zhang, Wenyan Wu, Chaofeng Ma, Chunyu Du, Yueru Huang, Haixia Xu, Cencen Li, Xiaofang Cheng, Ruijie Hao, Yongjie Xu
  Cells.2022; 11(15): 2357.     CrossRef
• The Effect of Swimming Training with Cinnamon Consumption on β3-AR and ERK2 Gene Expression in the Visceral Adipose Tissue of Diabetic Rats
  Kianoosh Mohammadi, Ali Khajehlandi, Amin Mohammadi
  Gene, Cell and Tissue.2022;[Epub]     CrossRef
• Of mice and men: Considerations on adipose tissue physiology in animal models of obesity and human studies
  Ioannis G. Lempesis, Dimitrios Tsilingiris, Junli Liu, Maria Dalamaga
  Metabolism Open.2022; 15: 100208.     CrossRef
• The comparison of the effect of acute moderate and high-intensity exercise on the uncoupling protein -1 secretion
  Desiana Merawati, Sugiharto Sugiharto, Adi Pranoto, Olivia Andiana, Prayogi Dwina Angga
  Jurnal SPORTIF : Jurnal Penelitian Pembelajaran.2022; 8(2): 201.     CrossRef
• Omega-3 Polyunsaturated Fatty Acids Protect against High-Fat Diet-Induced Morphological and Functional Impairments of Brown Fat in Transgenic Fat-1 Mice
  Lei Hao, Yong-Hui Nie, Chih-Yu Chen, Xiang-Yong Li, Kanakaraju Kaliannan, Jing X. Kang
  International Journal of Molecular Sciences.2022; 23(19): 11903.     CrossRef
• Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
  Vitor Ferreira, Cintia Folgueira, Maria Guillén, Pablo Zubiaur, Marcos Navares, Assel Sarsenbayeva, Pilar López-Larrubia, Jan W. Eriksson, Maria J. Pereira, Francisco Abad-Santos, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde
  Metabolism.2022; 137: 155335.     CrossRef
• Okra (Abelmoschus esculentus L. Moench) prevents obesity by reducing lipid accumulation and increasing white adipose browning in high-fat diet-fed mice
  Heegu Jin, Hyun-Ji Oh, Sehaeng Cho, Ok-Hwan Lee, Boo-Yong Lee
  Food & Function.2022; 13(22): 11840.     CrossRef
• Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans
  Ming Zhou, Tianzhen Wu, Yue Chen, Shixia Xu, Guang Yang, Anne Yoder
  Molecular Biology and Evolution.2022;[Epub]     CrossRef
• Brown adipose tissue transplantation as a novel alternative to obesity treatment: a systematic review
  Moloud Payab, Mina Abedi, Najmeh Foroughi Heravani, Mahdieh Hadavandkhani, Maryam Arabi, Akram Tayanloo-Beik, Motahareh Sheikh Hosseini, Hadis Gerami, Fateme Khatami, Bagher Larijani, Mohammad Abdollahi, Babak Arjmand
  International Journal of Obesity.2021; 45(1): 109.     CrossRef
• Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
  Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang
  Pharmacological Research.2021; 164: 105291.     CrossRef
• Inducible beige adipocytes improve impaired glucose metabolism in interscapular BAT-removal mice
  Xiao-Wei Jia, Dong-Liang Fang, Xin-Yi Shi, Tao Lu, Chun Yang, Yan Gao
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(3): 158871.     CrossRef
• NNT‐induced tumor cell “slimming” reverses the pro‐carcinogenesis effect of HIF2a in tumors
  Zhiyong Xiong, Wei Xiong, Wen Xiao, Changfei Yuan, Jian Shi, Yu Huang, Cheng Wang, Xiangui Meng, Zhixian Chen, Hongmei Yang, Ke Chen, Xiaoping Zhang
  Clinical and Translational Medicine.2021;[Epub]     CrossRef
• CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells
  Smarajit Chakraborty, Wee Kiat Ong, Winifred W. Y. Yau, Zhihong Zhou, K. N. Bhanu Prakash, Sue-Anne Toh, Weiping Han, Paul M. Yen, Shigeki Sugii
  Stem Cell Research & Therapy.2021;[Epub]     CrossRef
• Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential
  Hyeonyeong Im, Ji-Hyun Park, Seowoo Im, Juhyeong Han, Kyungmin Kim, Yun-Hee Lee
  Archives of Pharmacal Research.2021; 44(2): 133.     CrossRef
• 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
  Kang-Yun Lu, Shinn-Zong Lin, Kingsley Theras Primus Dass, Wei-Ju Lin, Shih-Ping Liu, Horng-Jyh Harn
  Biomedicine & Pharmacotherapy.2021; 139: 111687.     CrossRef
• Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3
  Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jae‐Young Um
  The FASEB Journal.2021;[Epub]     CrossRef
• Cajanolactone A, a Stilbenoid From Cajanus canjan (L.) Millsp, Prevents High-Fat Diet-Induced Obesity via Suppressing Energy Intake
  Zhuohui Luo, Jiawen Huang, Zhiping Li, Zhiwen Liu, Linchun Fu, Yingjie Hu, Xiaoling Shen
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review
  Michalina Banaszak, Ilona Górna, Juliusz Przysławski
  Nutrients.2021; 13(6): 2023.     CrossRef
• Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy
  Yinghan Chan, Sin Wi Ng, Joycelin Zhu Xin Tan, Gaurav Gupta, Poonam Negi, Lakshmi Thangavelu, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Wei Hsum Yap, Sachin Kumar Singh, Vanni Caruso, Kamal Dua, Dinesh Kumar Chellappan
  South African Journal of Botany.2021; 143: 176.     CrossRef
• Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis
  Michael S. Kuefner, Erin Stephenson, Mladen Savikj, Heather S. Smallwood, Qingming Dong, Christine Payré, Gérard Lambeau, Edwards A. Park
  The FASEB Journal.2021;[Epub]     CrossRef
• N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes
  Kang-Yun Lu, Kingsley Theras Primus Dass, Shinn-Zong Lin, Yu-Hua Tseng, Shih-Ping Liu, Horng-Jyh Harn
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(12): 159033.     CrossRef
• Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning
  Jie Li, Qiyang Chen, Xiuming Zhai, Dan Wang, Yujia Hou, Min Tang
  Food Science & Nutrition.2021; 9(12): 6548.     CrossRef
• Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway
  Ji-Yeon Lee, Minyoung Lee, Ji Young Lee, Jaehyun Bae, Eugene Shin, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
  Diabetes & Metabolism Journal.2021; 45(6): 921.     CrossRef
• The increase of uncoupling protein-1 expression after moderate intensity continuous exercises in obese females
  Sugiharto, Banih Sakti Adji, Desiana Merawati, Adi Pranoto
  Jurnal SPORTIF : Jurnal Penelitian Pembelajaran.2021; 7(2): 194.     CrossRef
• Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity
  Naimeh Mesri Alamdari, Pardis Irandoost, Neda Roshanravan, Mohammadreza Vafa, Mohammad Asghari Jafarabadi, Shahriar Alipour, Leila Roshangar, Mohammadreza Alivand, Farnaz Farsi, Farzad Shidfar
  Nutrition & Metabolism.2020;[Epub]     CrossRef
• Metabolic Benefits of MicroRNA-22 Inhibition
  Marc Thibonnier, Christine Esau
  Nucleic Acid Therapeutics.2020; 30(2): 104.     CrossRef
• Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet
  Cecilia Rodriguez Lanzi, Diahann J. Perdicaro, Julián Gambarte Tudela, Victoria Muscia, Ariel R. Fontana, Patricia I. Oteiza, Marcela A. Vazquez Prieto
  Food & Function.2020; 11(2): 1537.     CrossRef
• Citrus aurantium L. polymethoxyflavones promote thermogenesis of brown and white adipose tissue in high-fat diet induced C57BL/6J mice
  Guangning Kou, Yan Hu, Zixiao Jiang, Zhenqing Li, Peiyuan Li, Hongjie Song, Qiyang Chen, Zhiqin Zhou, Quanjun Lyu
  Journal of Functional Foods.2020; 67: 103860.     CrossRef
• Beneficial effects of pomegranate peel extract treatment on anthropometry and body composition of overweight patients with diabetes mellitus type-2: A randomised clinical trial
  Milkica Grabež, Ranko Škrbić, Miloš Stojiljković, Vesna Rudić-Grujić, Katarina Šavikin, Nebojša Menković, Gordana Zdunić, Nađa Vasiljević
  Scripta Medica.2020; 51(1): 21.     CrossRef
• Milk fat globule membrane and its component phosphatidylcholine induce adipose browning both in vivo and in vitro
  Tiange Li, Min Du, Hanning Wang, Xueying Mao
  The Journal of Nutritional Biochemistry.2020; 81: 108372.     CrossRef
• Dynamic contrast‐enhanced MRI of brown and beige adipose tissues
  Jadegoud Yaligar, Sanjay Kumar Verma, Venkatesh Gopalan, Rengaraj Anantharaj, Giang Thi Thu Le, Kavita Kaur, Karthik Mallilankaraman, MK Leow, SS Velan
  Magnetic Resonance in Medicine.2020; 84(1): 384.     CrossRef
• Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model
  Kyoung Soo Kim, Hari Madhuri Doss, Hee-Jin Kim, Hyung-In Yang
  Foods.2020; 9(6): 688.     CrossRef
• White adipose tissue browning in critical illness: A review of the evidence, mechanisms and future perspectives
  Elham Alipoor, Mohammad Javad Hosseinzadeh‐Attar, Mahsa Rezaei, Shima Jazayeri, Marianne Chapman
  Obesity Reviews.2020;[Epub]     CrossRef
• Metabolic and energetic benefits of microRNA-22 inhibition
  Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker
  BMJ Open Diabetes Research & Care.2020; 8(1): e001478.     CrossRef
• Apple polyphenols induce browning of white adipose tissue
  Yuki Tamura, Shigeto Tomiya, Junya Takegaki, Karina Kouzaki, Arata Tsutaki, Koichi Nakazato
  The Journal of Nutritional Biochemistry.2020; 77: 108299.     CrossRef
• Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo
  Kathleen R. Markan, Lauren K. Boland, Abdul Qaadir King-McAlpin, Kristin E. Claflin, Michael P. Leaman, Morgan K. Kemerling, Madison M. Stonewall, Brad A. Amendt, James A. Ankrum, Matthew J. Potthoff
  Molecular Metabolism.2020; 36: 100965.     CrossRef
• A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances
  Helda Tutunchi, Alireza Ostadrahimi, Mohammad‐Javad Hosseinzadeh‐Attar, Mahsa Miryan, Majid Mobasseri, Mehrangiz Ebrahimi‐Mameghani
  Obesity Reviews.2020;[Epub]     CrossRef
• Deficiency of glutathione peroxidase-1 and catalase attenuated diet-induced obesity and associated metabolic disorders
  Hyung-Ran Kim, Eun-Jeong Choi, Jeong-Hae Kie, Joo-Ho Lee, Ju-Young Seoh
  Acta Diabetologica.2020; 57(2): 151.     CrossRef
• Clinical Application Potential of Small Molecules that Induce Brown Adipose Tissue Thermogenesis by Improving Fat Metabolism
  Kang-Yun Lu, Kingsley Theras Primus Dass, Sheng-Feng Tsai, Hong-Meng Chuang, Shinn-Zong Lin, Shih-Ping Liu, Horng-Jyh Harn
  Cell Transplantation.2020; 29: 096368972092739.     CrossRef
• MiR‐92a regulates brown adipocytes differentiation, mitochondrial oxidative respiration, and heat generation by targeting SMAD7
  Zhipin Zhang, Huixin Jiang, Xiang Li, Xiaomin Chen, Yihua Huang
  Journal of Cellular Biochemistry.2020; 121(8-9): 3825.     CrossRef
• Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α
  Darren M. Gordon, Kari L. Neifer, Abdul-Rizaq Ali Hamoud, Charles F. Hawk, Andrea L. Nestor-Kalinoski, Scott A. Miruzzi, Michael P. Morran, Samuel O. Adeosun, Jeffrey G. Sarver, Paul W. Erhardt, Robert E. McCullumsmith, David E. Stec, Terry D. Hinds
  Journal of Biological Chemistry.2020; 295(29): 9804.     CrossRef
• The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans
  Oana C Kulterer, Laura Niederstaetter, Carsten T Herz, Alexander R Haug, Andrea Bileck, Dietmar Pils, Alexandra Kautzky-Willer, Christopher Gerner, Florian W Kiefer
  The Journal of Clinical Endocrinology & Metabolism.2020; 105(7): 2203.     CrossRef
• Downregulation of osteopontin inhibits browning of white adipose tissues through PI3K-AKT pathway in C57BL / 6 mice
  Yi Lu, Yuhong Xu, Wanwan Yuan, Mengxi Wang, Yumeng Zhou, Kai Chen, Qiren Huang
  European Journal of Pharmacology.2020; 866: 172822.     CrossRef
• Angiotensin AT1 receptor antagonism by losartan stimulates adipocyte browning via induction of apelin
  Dong Young Kim, Mi Jin Choi, Tae Kyung Ko, Na Hyun Lee, Ok-Hee Kim, Hyae Gyeong Cheon
  Journal of Biological Chemistry.2020; 295(44): 14878.     CrossRef
• Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition
  Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Sang Woo Kim
  Molecules.2020; 25(23): 5660.     CrossRef
• In vitro evaluation of Hydrilla verticillata for anti-adipogenesis activity on 3T3 L1 cell lines
  SPandi Prabha, S Sadhana, C Karthik, DG Caroline
  Pharmacognosy Magazine.2020; 16(5): 498.     CrossRef
• Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
  Jie Wang, Jing Ge, Haigang Cao, Xiaoyu Zhang, Yuan Guo, Xiao Li, Bo Xia, Gongshe Yang, Xin’e Shi
  Cells.2019; 8(4): 372.     CrossRef
• Impact of Gut Microbiota on Host Glycemic Control
  Céline Gérard, Hubert Vidal
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity
  Oh Yoen Kim, Ji Yeon Chung, Juhyun Song
  Pharmacological Research.2019; 148: 104411.     CrossRef
• A comprehensive diagnostic approach to detect underlying causes of obesity in adults
  Eline S. van der Valk, Erica L.T. van den Akker, Mesut Savas, Lotte Kleinendorst, Jenny A. Visser, Mieke M. Van Haelst, Arya M. Sharma, Elisabeth F.C. van Rossum
  Obesity Reviews.2019; 20(6): 795.     CrossRef
• Prostacyclin: A major prostaglandin in the regulation of adipose tissue development
  Mohammad Sharifur Rahman
  Journal of Cellular Physiology.2019; 234(4): 3254.     CrossRef
• The expression of brown fat‐associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis
  Abdo Alnabulsi, Beatriz Cash, Yehfang Hu, Linda Silina, Ayham Alnabulsi, Graeme I. Murray
  International Journal of Cancer.2019; 145(4): 1138.     CrossRef
• Garlic augments the functional and nutritional behavior of Doenjang, a traditional Korean fermented soybean paste
  Ashutosh Bahuguna, Shruti Shukla, Jong Suk Lee, Vivek K. Bajpai, So-Young Kim, Yun Suk Huh, Young-Kyu Han, Myunghee Kim
  Scientific Reports.2019;[Epub]     CrossRef
• Clomiphene promotes browning of white adipocytes via casein kinase-2 inhibition
  Hyun-Jin Kim, Dong Young Kim, Hyae Gyeong Cheon
  European Journal of Pharmacology.2019; 861: 172596.     CrossRef
• Neuroendocrine Regulation of Energy Metabolism Involving Different Types of Adipose Tissues
  Qi Zhu, Bradley J. Glazier, Benjamin C. Hinkel, Jingyi Cao, Lin Liu, Chun Liang, Haifei Shi
  International Journal of Molecular Sciences.2019; 20(11): 2707.     CrossRef
• Tumor Cell “Slimming” Regulates Tumor Progression through PLCL1/UCP1‐Mediated Lipid Browning
  Zhiyong Xiong, Wen Xiao, Lin Bao, Wei Xiong, Haibing Xiao, Yan Qu, Changfei Yuan, Hailong Ruan, Qi Cao, Keshan Wang, Zhengshuai Song, Cheng Wang, Wenjun Hu, Zeyuan Ru, Junwei Tong, Gong Cheng, Tianbo Xu, Xiangui Meng, Jian Shi, Zhixian Chen, Hongmei Yang,
  Advanced Science.2019;[Epub]     CrossRef
• Soyasaponin Ab alleviates postmenopausal obesity through browning of white adipose tissue
  Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee Do
  Journal of Functional Foods.2019; 57: 453.     CrossRef
• Beneficial Effects of Pomegranate Peel Extract and Probiotics on Pre-adipocyte Differentiation
  Valeria Sorrenti, Cinzia Lucia Randazzo, Cinzia Caggia, Gabriele Ballistreri, Flora Valeria Romeo, Simona Fabroni, Nicolina Timpanaro, Marco Raffaele, Luca Vanella
  Frontiers in Microbiology.2019;[Epub]     CrossRef
• Visfatin; a potential novel mediator of brown adipose tissue
  Parmida Pourvali-Talatappeh, Elham Alipoor
  Obesity Medicine.2019; 15: 100122.     CrossRef
• Strategies and methods for the correction of obesity and associated cardiovascular risk
  T. Yu. Kuznetsova, M. A. Druzhilov, G. A. Chumakova, N. D. Veselovskaya
  Russian Journal of Cardiology.2019; (4): 61.     CrossRef
• Polymeric Carriers for Controlled Drug Delivery in Obesity Treatment
  Di Huang, Meng Deng, Shihuan Kuang
  Trends in Endocrinology & Metabolism.2019; 30(12): 974.     CrossRef
• Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway
  Wei Sun, Xuemei Zhao, Zhengqi Wang, Yi Chu, Liufeng Mao, Shaoqiang Lin, Xuefei Gao, Yuna Song, Xiaoyan Hui, Shiqi Jia, Shibing Tang, Yong Xu, Aimin Xu, Kerry Loomes, Cunchuan Wang, Donghai Wu, Tao Nie
  Molecular Metabolism.2019; 28: 48.     CrossRef
• Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice
  Kyung-Ah Park, Zhen Jin, Hyeong Seok An, Jong Youl Lee, Eun Ae Jeong, Eun Bee Choi, Kyung Eun Kim, Hyun Joo Shin, Jung Eun Lee, Gu Seob Roh
  The Korean Journal of Physiology & Pharmacology.2019; 23(5): 335.     CrossRef
• Peripherally administered melanocortins induce mice fat browning and prevent obesity
  Adriana R. Rodrigues, Maria J. Salazar, Sílvia Rocha-Rodrigues, Inês O. Gonçalves, Célia Cruz, Delminda Neves, Henrique Almeida, José Magalhães, Alexandra M. Gouveia
  International Journal of Obesity.2019; 43(5): 1058.     CrossRef
• Chinese medicine Jinlida granules improve high-fat-diet induced metabolic disorders via activation of brown adipose tissue in mice
  Hui Zhang, Yuanyuan Hao, Cong Wei, Bing Yao, Shen Liu, Hongru Zhou, Dan Huang, Chuanhai Zhang, Yiling Wu
  Biomedicine & Pharmacotherapy.2019; 114: 108781.     CrossRef
• Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
  G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
  International Journal of Obesity.2018; 42(3): 542.     CrossRef
• Air Pollution Has a Significant Negative Impact on Intentional Efforts to Lose Weight: A Global Scale Analysis
  Morena Ustulin, So Young Park, Sang Ouk Chin, Suk Chon, Jeong-taek Woo, Sang Youl Rhee
  Diabetes & Metabolism Journal.2018; 42(4): 320.     CrossRef
• Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet
  Fenglin Zhang, Wei Ai, Xiaoquan Hu, Yingying Meng, Cong Yuan, Han Su, Lina Wang, Xiaotong Zhu, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
  Food & Function.2018; 9(4): 2043.     CrossRef
• Nobiletin induces brown adipocyte-like phenotype and ameliorates stress in 3T3-L1 adipocytes
  Jameel Lone, Hilal Ahmad Parray, Jong Won Yun
  Biochimie.2018; 146: 97.     CrossRef
• Regular aerobic exercise correlates with reduced anxiety and incresed levels of irisin in brain and white adipose tissue
  Nazan Uysal, Oguz Yuksel, Servet Kizildag, Zeynep Yuce, Hikmet Gumus, Aslı Karakilic, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates
  Neuroscience Letters.2018; 676: 92.     CrossRef
• The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice
  Mi Song, Soo-Kyoung Lim, Jing-Hua Wang, Hojun Kim
  International Journal of Molecular Sciences.2018; 19(1): 278.     CrossRef
• Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice
  Tamiris Lima Rachid, Flavia Maria Silva-Veiga, Francielle Graus-Nunes, Isabele Bringhenti, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello, Nobuyuki Takahashi
  PLOS ONE.2018; 13(1): e0191365.     CrossRef
• Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes
  Linkang Zhou, Miao Yu, Muhammad Arshad, Wenmin Wang, Ye Lu, Jingyi Gong, Yangnan Gu, Peng Li, Li Xu
  Diabetes.2018; 67(10): 1935.     CrossRef
• Lithocholic Acid Improves the Survival of Drosophila Melanogaster
  Stefanie Staats, Gerald Rimbach, Axel Kuenstner, Simon Graspeuntner, Jan Rupp, Hauke Busch, Christian Sina, Ignacio R. Ipharraguerre, Anika E. Wagner
  Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
• Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue
  Songpei Li, Xiu Zhou, Eunjung Jo, Ali Mahzari, Sherouk Fouda, Dongli Li, Kun Zhang, Ji-Ming Ye
  Bioscience Reports.2018;[Epub]     CrossRef
• Alternative mRNA Splicing in the Pathogenesis of Obesity
  Chi-Ming Wong, Lu Xu, Mabel Yau
  International Journal of Molecular Sciences.2018; 19(2): 632.     CrossRef
• Krüppel-Like Factors
  Nina M. Pollak, Matthew Hoffman, Ira J. Goldberg, Konstantinos Drosatos
  JACC: Basic to Translational Science.2018; 3(1): 132.     CrossRef
• Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
  Stefanie Worsch, Mathias Heikenwalder, Hans Hauner, Bernhard L. Bader
  Nutrition & Metabolism.2018;[Epub]     CrossRef
• Combination of Capsaicin and Hesperidin Reduces the Effectiveness of Each Compound To Decrease the Adipocyte Size and To Induce Browning Features in Adipose Tissue of Western Diet Fed Rats
  Andrea Mosqueda-Solís, Juana Sánchez, María P. Portillo, Andreu Palou, Catalina Picó
  Journal of Agricultural and Food Chemistry.2018; 66(37): 9679.     CrossRef
• Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
  Robin van Eenige, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman
  Trends in Endocrinology & Metabolism.2018; 29(5): 326.     CrossRef
• Cardiovascular and Metabolic Heterogeneity of Obesity
  Ian J. Neeland, Paul Poirier, Jean-Pierre Després
  Circulation.2018; 137(13): 1391.     CrossRef
• Zinc alpha2 glycoprotein promotes browning in adipocytes
  Xin-Hua Xiao, Xiao-Yan Qi, Ya-Di Wang, Li Ran, Jing Yang, Huan-Li Zhang, Can-Xin Xu, Ge-Bo Wen, Jiang-Hua Liu
  Biochemical and Biophysical Research Communications.2018; 496(2): 287.     CrossRef
• Impacts of High Sodium Intake on Obesity-related Gene Expression
  Minjee Lee, Miyoung Park, Juhee Kim, Soyoung Sung, Myoungsook Lee
  Journal of the East Asian Society of Dietary Life.2018; 28(5): 364.     CrossRef
• Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
  Perla P. Argentato, Helena de Cássia César, Débora Estadella, Luciana P. Pisani
  British Journal of Nutrition.2018; 120(6): 619.     CrossRef
• Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice
  Zili Wang, Brian T. Feeley, Hubert T. Kim, Xuhui Liu
  Clinical Orthopaedics & Related Research.2018; 476(8): 1665.     CrossRef
• Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study
  Gyuri Kim, Seung-Eun Lee, Ji Eun Jun, You-Bin Lee, Jiyeon Ahn, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon-Kyu Lee, Jae Hyeon Kim
  Cardiovascular Diabetology.2018;[Epub]     CrossRef
• Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice
  Tao Hu, Xiaoxue Yuan, Gang Wei, Haoshu Luo, Hyuek Jong Lee, Wanzhu Jin
  European Journal of Nutrition.2018; 57(1): 391.     CrossRef
• Effects of growth hormone on uncoupling protein 1 in white adipose tissues in obese mice
  Misa Hayashi, Kumi Futawaka, Rie Koyama, Yue Fan, Midori Matsushita, Asuka Hirao, Yuki Fukuda, Ayako Nushida, Syoko Nezu, Tetsuya Tagami, Kenji Moriyama
  Growth Hormone & IGF Research.2017; 37: 31.     CrossRef
• Position paper of the European Society of Cardiology–working group of coronary pathophysiology and microcirculation: obesity and heart disease
  Lina Badimon, Raffaele Bugiardini, Edina Cenko, Judit Cubedo, Maria Dorobantu, Dirk J. Duncker, Ramón Estruch, Davor Milicic, Dimitris Tousoulis, Zorana Vasiljevic, Gemma Vilahur, Cor de Wit, Akos Koller
  European Heart Journal.2017; 38(25): 1951.     CrossRef
• Browning of Abdominal Aorta Perivascular Adipose Tissue Inhibits Adipose Tissue Inflammation
  Run-Mei Li, Sui-Qing Chen, Ning-Xi Zeng, Shu-Hui Zheng, Li Guan, Hai-Mei Liu, Le-Quan Zhou, Jin-Wen Xu
  Metabolic Syndrome and Related Disorders.2017; 15(9): 450.     CrossRef
• The role of adipose tissue in cancer-associated cachexia
  Janina A Vaitkus, Francesco S Celi
  Experimental Biology and Medicine.2017; 242(5): 473.     CrossRef
• Hormonal factors in the control of the browning of white adipose tissue
  Jiamiao Hu, Mark Christian
  Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
• European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
  Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Adem
  Redox Biology.2017; 13: 94.     CrossRef
• Resveratrol enhances brown adipocyte formation and function by activating AMP‐activated protein kinase (AMPK) α1 in mice fed high‐fat diet
  Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
  Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
• Adipoz doku ve enerji metabolizması üzerine etkileri
  Meltem Mermer, Nilüfer Acar TEK
  SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
• Physiological roles of macrophages
  Siamon Gordon, Luisa Martinez-Pomares
  Pflügers Archiv - European Journal of Physiology.2017; 469(3-4): 365.     CrossRef
• Brown Adipose Tissue Bioenergetics: A New Methodological Approach
  María Calderon‐Dominguez, Martín Alcalá, David Sebastián, Antonio Zorzano, Marta Viana, Dolors Serra, Laura Herrero
  Advanced Science.2017;[Epub]     CrossRef
• Honokiol exerts dual effects on browning and apoptosis of adipocytes
  Jameel Lone, Jong Won Yun
  Pharmacological Reports.2017; 69(6): 1357.     CrossRef
• The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice
  Miyoung Song
  Journal of Korean Medicine for Obesity Research.2017; 17(2): 119.     CrossRef
• Brown Adipose Tissue: an Update on Recent Findings
  Kara L. Marlatt, Eric Ravussin
  Current Obesity Reports.2017; 6(4): 389.     CrossRef
• Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism
  Yin Li, Xin Liu, Yu Fan, Baican Yang, Cheng Huang
  PeerJ.2017; 5: e3305.     CrossRef
• Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling
  Shannon H. Carroll, Ellen Zhang, Bing F. Wang, Katherine B. LeClair, Arifeen Rahman, David E. Cohen, Jorge Plutzky, Parth Patwari, Richard T. Lee, Makoto Kanzaki
  PLOS ONE.2017; 12(3): e0173823.     CrossRef
• Effect of Long-Term Green Tea Extract Supplementation on Peripheral Blood Leukocytes in CrossFit-Trained and Untrained Men
  Agata Żak, Ilona Pokora
  Central European Journal of Sport Sciences and Medicine.2017; 19: 67.     CrossRef
• Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa
  Lingyu Zhang, Dan Wang, Min Wen, Lei Du, Changhu Xue, Jingfeng Wang, Jie Xu, Yuming Wang
  Journal of Functional Foods.2017; 28: 28.     CrossRef
• Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
  Cécile Milet, Marianne Bléher, Kassandra Allbright, Mickael Orgeur, Fanny Coulpier, Delphine Duprez, Emmanuelle Havis
  Scientific Reports.2017;[Epub]     CrossRef
• Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders
  Marco Tozzi, Ivana Novak
  Frontiers in Pharmacology.2017;[Epub]     CrossRef
• Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice
  Eunju Kim, Soo-Min Lim, Min-Soo Kim, Sang-Ho Yoo, Yuri Kim
  Nutrients.2017; 9(10): 1049.     CrossRef
• Yogurt and Cardiometabolic Diseases: A Critical Review of Potential Mechanisms
  Melissa Anne Fernandez, Shirin Panahi, Noémie Daniel, Angelo Tremblay, André Marette
  Advances in Nutrition.2017; 8(6): 812.     CrossRef
• Système endocannabinoïde : effets sur le métabolisme glucidique, mais aussi lipidique
  A.-L. Sberna, P. Degrace, B. Vergès
  Médecine des Maladies Métaboliques.2016; 10(5): 407.     CrossRef
• The Fat Side of the Endocannabinoid System: Role of Endocannabinoids in the Adipocyte
  Isabelle Matias, Ilaria Belluomo, Daniela Cota
  Cannabis and Cannabinoid Research.2016; 1(1): 176.     CrossRef
• Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathwayin vivoandin vitro
  Endong Zhu, Yang Yang, Juanjuan Zhang, Yongmei Li, Chunjun Li, Liming Chen, Bei Sun
  Oncotarget.2016; 7(49): 81077.     CrossRef
• NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
  Zhongshu Li, Shenghu Feng, Li Zhou, Shunai Liu, Jun Cheng
  Biochemical and Biophysical Research Communications.2016; 475(1): 133.     CrossRef
• Novel device for male infertility screening with single-ball lens microscope and smartphone
  Yoshitomo Kobori, Peter Pfanner, Gail S. Prins, Craig Niederberger
  Fertility and Sterility.2016; 106(3): 574.     CrossRef
• An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
  Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson
  Gastroenterology.2016; 151(5): 845.     CrossRef
• Feast and famine: Adipose tissue adaptations for healthy aging
  Daniele Lettieri Barbato, Katia Aquilano
  Ageing Research Reviews.2016; 28: 85.     CrossRef
• Hypothalamus and thermogenesis: Heating the BAT, browning the WAT
  Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Gema Medina-Gómez, Miguel López
  Molecular and Cellular Endocrinology.2016; 438: 107.     CrossRef
• Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes
  Yung-Li Wang, Shih-Pei Lin, Patrick C.H. Hsieh, Shih-Chieh Hung
  Biochemical and Biophysical Research Communications.2016; 478(2): 689.     CrossRef

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been identified to date. A correct genetic diagnosis is important as it often leads to personalized treatment for those with diabetes and enables predictive genetic testing for their asymptomatic relatives. Next-generation sequencing may provide an efficient method for screening mutations in this form of diabetes as well as identifying new MODY genes. In this review, I discuss a current update on MODY in the literatures and cover the studies that have been performed in Korea.

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Citations to this article as recorded by  

• Alteraciones en el NeuroD1. Causa infrecuente de diabetes infantil y juvenil
  Ana Isabel García Muñoz, María José Ballester Herrera, Elena Martín Campagne, Enrique Palomo Atance
  Endocrinología, Diabetes y Nutrición.2023; 70(6): 438.     CrossRef
• An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells
  Florian M. Hermann, Maya Friis Kjærgaard, Chenglei Tian, Ulf Tiemann, Abigail Jackson, Lars Rønn Olsen, Maria Kraft, Per-Ola Carlsson, Iina M. Elfving, Jarno L.T. Kettunen, Tiinamaija Tuomi, Ivana Novak, Henrik Semb
  Cell Stem Cell.2023; 30(1): 38.     CrossRef
• Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults: a nationwide, multi-center, cross-sectional survey in China
  Yan Chen, Jing Zhao, Xia Li, Zhiguo Xie, Gan Huang, Xiang Yan, Houde Zhou, Li Zheng, Tao Xu, Kaixin Zhou, Zhiguang Zhou
  Chinese Medical Journal.2023; 136(1): 56.     CrossRef
• In Silico Molecular Docking Studies of Phytocompounds From Coleus Amboinicus Against Glucokinase
  Soosai Marian Anthony Ammal, Sai Sudha, Durairaj Rajkumar, Adhithya Baskaran, Gunasekaran Krishnamoorthy , Madurai Kannan Anbumozhi
  Cureus.2023;[Epub]     CrossRef
• The Pathogenesis of Diabetes
  Huiqin Guo, Haili Wu, Zhuoyu Li
  International Journal of Molecular Sciences.2023; 24(8): 6978.     CrossRef
• Time to reposition sulfonylureas in type 2 diabetes management in Indian context: A pragmatic practical approach
  Ashok Kumar Das, Banshi Saboo, Rajeev Chawla, S. R. Aravind, Rajesh Rajput, Awadhesh K. Singh, J. J. Mukherjee, Ashok Jhingan, Parag Shah, Vaishali Deshmukh, Shailaja Kale, Shalini Jaggi, G. R. Sridhar, Rajnish Dhediya, Kumar Gaurav
  International Journal of Diabetes in Developing Countries.2023; 43(6): 856.     CrossRef
• A young‐onset type 2 diabetic Chinese girl with familial renal glycosuria caused by a novel mutation in SLC5A2: A case report
  Yuqing Qu, Limei Hao, Xianling Wang
  Journal of Diabetes.2023; 15(7): 622.     CrossRef
• Genetic and clinical characteristics of Turkish children with Maturity Onset Diabetes of the Young Type 2 (MODY2): A single center experience
  Özlem NALBANTOĞLU, Semra GÜRSOY, Tarık KIRKGÖZ, Filiz HAZAN, Behzat ÖZKAN
  Interdisciplinary Medical Journal.2023; 14(48): 51.     CrossRef
• Alterations in NeuroD1. Infrequent cause of infantile and juvenile diabetes
  Ana Isabel García Muñoz, María José Ballester Herrera, Elena Martín Campagne, Enrique Palomo Atance
  Endocrinología, Diabetes y Nutrición (English ed.).2023; 70(6): 438.     CrossRef
• Quantitative profiling and diagnostic potential of one-carbon and central metabolism pools in MODY2 and T1DM
  Jieying Liu, Ziyan Xie, Junling Fu, Miao Yu, Tong Wang, Cuijuan Qi, Peng Liu, Xiangyi Hui, Dongmei Wang, Lu Ding, Qian Zhang, Ting Xie, Xinhua Xiao
  Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
• Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions
  Hong-Yan Sun, Xiao-Yan Lin
  World Journal of Diabetes.2023; 14(12): 1738.     CrossRef
• Molecular and clinical assessment of maturity-onset diabetes of the young revealed low mutational rate in Moroccan families
  Said Trhanint, Laila Bouguenouch, Sana Abourazzak, Hanan El Ouahabi, Hanane Latrech, Salma Benyakhlef, Bahia Bennani, Ihssane El Bouchikhi, Fatima Zahra Moufid, Karim Ouldim, Lahsen El Ghadraoui, Nadia Maazouzi
  International Journal of Pediatrics and Adolescent Medicine.2022; 9(2): 98.     CrossRef
• Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study
  Carolina G. Downie, Sofia F. Dimos, Stephanie A. Bien, Yao Hu, Burcu F. Darst, Linda M. Polfus, Yujie Wang, Genevieve L. Wojcik, Ran Tao, Laura M. Raffield, Nicole D. Armstrong, Hannah G. Polikowsky, Jennifer E. Below, Adolfo Correa, Marguerite R. Irvin,
  Diabetologia.2022; 65(3): 477.     CrossRef
• When do we need to suspect maturity onset diabetes of the young in patients with type 2 diabetes mellitus?
  Özlem Üstay, Tugçe Apaydın, Onur Elbasan, Hamza Polat, Gizem Günhan, Ceyda Dinçer, Lamia Şeker, Esra Arslan Ateş, Ayşegül Yabacı, Ahmet lter Güney, Dilek Gogas Yavuz
  Archives of Endocrinology and Metabolism.2022;[Epub]     CrossRef
• Precision Diagnosis of Maturity-Onset Diabetes of the Young with Next-Generation Sequencing: Findings from the MODY-IST Study in Adult Patients
  Hulya Yilmaz Aydogan, Nurdan Gul, Deniz Kanca Demirci, Ummu Mutlu, Gizem Gulfidan, Kazim Yalcin Arga, Aclan Ozder, Ahmet Adil Camli, Yildiz Tutuncu, Oguz Ozturk, Canan Cacina, Feyza Darendeliler, Sukran Poyrazoglu, Ilhan Satman
  OMICS: A Journal of Integrative Biology.2022; 26(4): 218.     CrossRef
• Clinical Characteristics of Patients With HNF1-alpha MODY: A Literature Review and Retrospective Chart Review
  Qinying Zhao, Li Ding, Ying Yang, Jinhong Sun, Min Wang, Xin Li, Ming Liu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• ABCC8 ‐related maturity‐onset diabetes of the young: Clinical features and genetic analysis of one case
  Yun Zhou, Yan Sun, Chao Xu, Fan Liu, Yuye Gao, Caihong Liu, Yu Qiao, Jianmei Yang, Guimei Li
  Pediatric Diabetes.2022; 23(5): 588.     CrossRef
• Precision therapy for three Chinese families with maturity-onset diabetes of the young (MODY12)
  Juyi Li, Xiufang Wang, Huihui Mao, Li Wen, Aiping Deng, Yarong Li, Hongmei Zhang, Chao Liu
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Early-onset diabetes involving three consecutive generations had different clinical features from age-matched type 2 diabetes without a family history in China
  Da-Wei Wang, Jing Yuan, Fang-yuan Yang, Hai-Yan Qiu, Jing Lu, Jin-Kui Yang
  Endocrine.2022; 78(1): 47.     CrossRef
• UDP-glucose, cereblon-dependent proinsulin degrader
  Jaeyong Cho, Atsushi Miyagawa, Kazuki Yamaguchi, Wakana Abe, Yoji Tsugawa, Hatsuo Yamamura, Takeshi Imai
  Scientific Reports.2022;[Epub]     CrossRef
• Maturity-Onset Diabetes of the Young: Mutations, Physiological Consequences, and Treatment Options
  Hazar Younis, Se Eun Ha, Brian G. Jorgensen, Arushi Verma, Seungil Ro
  Journal of Personalized Medicine.2022; 12(11): 1762.     CrossRef
• Diagnosis and Treatment of Monogenic Forms of Diabetes Mellitus: Focus on Mody-Diabetes
  K. A. Aitbaev, I. T. Murkamilov, Zh. A. Murkamilova, V. V. Fomin, I. O Kudaibergenova, F. A. Yusupov
  The Russian Archives of Internal Medicine.2022; 12(6): 430.     CrossRef
• The Genetic Spectrum of Maturity-Onset Diabetes of the Young (MODY) in Qatar, a Population-Based Study
  Asma A. Elashi, Salman M. Toor, Ilhame Diboun, Yasser Al-Sarraj, Shahrad Taheri, Karsten Suhre, Abdul Badi Abou-Samra, Omar M. E. Albagha
  International Journal of Molecular Sciences.2022; 24(1): 130.     CrossRef
• MODY patients exhibit shorter telomere length than non‐diabetic subjects
  Andrea L. Millan, Sofía I. Trobo, Alejandro de Dios, Martina Cerrato García, María S. Pérez, Gloria E. Cerrone, Gustavo D. Frechtel, Ariel P. López
  Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
• Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells
  Chutima Charoensuk, Prapaporn Jungtrakoon Thamtarana, Chutima Chanprasert, Watip Tangjittipokin, Jun Shirakawa, Yu Togashi, Kazuki Orime, Pucharee Songprakhon, Chartchai Chaichana, Zuroida Abubakar, Paweena Ouying, Jatuporn Sujjitjoon, Alessandro Doria, N
  Molecular and Cellular Endocrinology.2021; 522: 111126.     CrossRef
• Late Diagnosis of Maturity-Onset Diabetes of the Young 12 With Catastrophic Consequences
  Nuno R Carreira, Catarina Gonçalves, Alexandra Wahnon, Sara Dâmaso, Joao Martins
  Cureus.2021;[Epub]     CrossRef
• Vanillic acid mitigates the impairments in glucose metabolism in HepG2 cells through BAD–GK interaction during hyperinsulinemia
  Mohan Sreelekshmi, Kozhiparambil Gopalan Raghu
  Journal of Biochemical and Molecular Toxicology.2021; 35(6): 1.     CrossRef
• Aberrant sialylation in a patient with a HNF1α variant and liver adenomatosis
  Luisa Sturiale, Marie-Cécile Nassogne, Angelo Palmigiano, Angela Messina, Immacolata Speciale, Rosangela Artuso, Gaetano Bertino, Nicole Revencu, Xavier Stephénne, Cristina De Castro, Gert Matthijs, Rita Barone, Jaak Jaeken, Domenico Garozzo
  iScience.2021; 24(4): 102323.     CrossRef
• A Clinical Prediction Model to Distinguish Maturity-Onset Diabetes of the Young From Type 1 and Type 2 Diabetes in the Chinese Population
  Junling Fu, Fan Ping, Tong Wang, Yiwen Liu, Xiaojing Wang, Jie Yu, Mingqun Deng, Jieying Liu, Qian Zhang, Miao Yu, Ming Li, Yuxiu Li, Xinhua Xiao
  Endocrine Practice.2021; 27(8): 776.     CrossRef
• Combination of disease duration‐to‐age at diagnosis and hemoglobin A1c‐to‐serum C‐peptide reactivity ratios predicts patient response to glucose‐lowering medication in type 2 diabetes: A retrospective cohort study across Japan (JDDM59)
  Azuma Kanatsuka, Yasunori Sato, Yoichiro Higashi, Yoshimasa Goto, Koichi Kawai, Hiroshi Maegawa
  Journal of Diabetes Investigation.2021; 12(11): 1967.     CrossRef
• Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients
  Dong-Hwa Lee, Soo-Heon Kwak, Hee Sue Park, Eu Jeong Ku, Hyun Jeong Jeon, Tae Keun Oh
  BMJ Open Diabetes Research & Care.2021; 9(1): e002217.     CrossRef
• Maturity Onset Diabetes of the Young—New Approaches for Disease Modelling
  Dawid Skoczek, Józef Dulak, Neli Kachamakova-Trojanowska
  International Journal of Molecular Sciences.2021; 22(14): 7553.     CrossRef
• Clinical and genetic features of maturity-onset diabetes of the young in pediatric patients: a 12-year monocentric experience
  Stefano Passanisi, Giuseppina Salzano, Bruno Bombaci, Fortunato Lombardo
  Diabetology & Metabolic Syndrome.2021;[Epub]     CrossRef
• Maturity onset diabetes of the young
  Muhammad Yassir Yaqub Qureshi, Rabia Nawaz
  InnovAiT: Education and inspiration for general practice.2021; 14(11): 669.     CrossRef
• Diagnosis and Treatment of MODY: An Updated Mini Review
  Abegail Tshivhase, Tandi Matsha, Shanel Raghubeer
  Applied Sciences.2021; 11(20): 9436.     CrossRef
• NEUROD1 mutation in an Italian patient with maturity onset diabetes of the young 6: a case report
  Lucia Brodosi, Bianca Baracco, Vilma Mantovani, Loris Pironi
  BMC Endocrine Disorders.2021;[Epub]     CrossRef
• Maturity-Onset Diabetes of Young Type 5: Diabetes with Extrapancreatic Features
  Adnan Haider, Oksana Symczyk, Ayesha Hassan, Muhammad Atif Khan, Inderpreet Madahar, Dylan Holland, Wayne V. Moore
  Case Reports in Endocrinology.2021; 2021: 1.     CrossRef
• Gençlerin Erişkin Başlangıçlı Diyabeti (MODY) Sorumlu HNF4A, GCK ve HNF1 Gen Varyasyonlarının Dünya Genelinde Coğrafik Dağılımı
  Deniz KANCA DEMİRCİ, Nurdan GÜL, İlhan SATMAN, Oguz OZTURK, Hülya YILMAZ AYDOĞAN
  Haliç Üniversitesi Fen Bilimleri Dergisi.2021; 4(1): 41.     CrossRef
• Fasting C‐peptide, a biomarker for hypoglycaemia risk in insulin‐naïve people with type 2 diabetes initiating basal insulin glargine 100 U/mL
  Wolfgang Landgraf, David R. Owens, Brian M. Frier, Mei Zhang, Geremia B. Bolli
  Diabetes, Obesity and Metabolism.2020; 22(3): 315.     CrossRef
• Molecular and clinical characteristics of monogenic diabetes mellitus in southern Chinese children with onset before 3 years of age
  Yunting Lin, Huiying Sheng, Tzer Hwu Ting, Aijing Xu, Xi Yin, Jing Cheng, Huifen Mei, Yongxian Shao, Chunhua Zeng, Wen Zhang, Min Rao, Li Liu, Xiuzhen Li
  BMJ Open Diabetes Research & Care.2020; 8(1): e001345.     CrossRef
• Maturity-onset diabetes of the young type 5 a MULTISYSTEMIC disease: a CASE report of a novel mutation in the HNF1B gene and literature review
  Juan Camilo Mateus, Carolina Rivera, Miguel O’Meara, Alex Valenzuela, Fernando Lizcano
  Clinical Diabetes and Endocrinology.2020;[Epub]     CrossRef
• Maturity-onset diabetes of the young: From a molecular basis perspective toward the clinical phenotype and proper management
  Sofia Castro Oliveira, João Sérgio Neves, Antonio Pérez, Davide Carvalho
  Endocrinología, Diabetes y Nutrición (English ed.).2020; 67(2): 137.     CrossRef
• Maturity-Onset Diabetes of the Young (MODY) in Portugal: Novel GCK, HNFA1 and HNFA4 Mutations
  Maria I. Alvelos, Catarina I. Gonçalves, Eduarda Coutinho, Joana T. Almeida, Margarida Bastos, Maria L. Sampaio, Miguel Melo, Sofia Martins, Isabel Dinis, Alice Mirante, Leonor Gomes, Joana Saraiva, Bernardo D. Pereira, Susana Gama-de-Sousa, Carolina More
  Journal of Clinical Medicine.2020; 9(1): 288.     CrossRef
• Maturity-onset diabetes of the young: update and perspectives on diagnosis and treatment
  Kyung Mi Jang
  Yeungnam University Journal of Medicine.2020; 37(1): 13.     CrossRef
• Maturity-onset diabetes of the young: From a molecular basis perspective toward the clinical phenotype and proper management
  Sofia Castro Oliveira, João Sérgio Neves, Antonio Pérez, Davide Carvalho
  Endocrinología, Diabetes y Nutrición.2020; 67(2): 137.     CrossRef
• A rare combination of MODY5 and duodenal atresia in a patient: a case report
  Tao Du, Nan Zeng, Xiaofang Wen, Peizhuang Zhu, Wangen Li
  BMC Medical Genetics.2020;[Epub]     CrossRef
• Molecular genetic study in a cohort of Iranian families suspected to maturity-onset diabetes of the young, reveals a recurrent mutation and a high-risk variant in the CEL gene
  Akram Sarmadi, Aliasgar Mohammadi, Fatemeh Tabatabaei, Zahra Nouri, MortezaHashemzadeh Chaleshtori, MohammadAmin Tabatabaiefar
  Advanced Biomedical Research.2020; 9(1): 25.     CrossRef
• Update on Monogenic Diabetes in Korea
  Ye Seul Yang, Soo Heon Kwak, Kyong Soo Park
  Diabetes & Metabolism Journal.2020; 44(5): 627.     CrossRef
• Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway
  Sophie L. Lewandowski, Rebecca L. Cardone, Hannah R. Foster, Thuong Ho, Evgeniy Potapenko, Chetan Poudel, Halena R. VanDeusen, Sophia M. Sdao, Tiago C. Alves, Xiaojian Zhao, Megan E. Capozzi, Arnaldo H. de Souza, Ishrat Jahan, Craig J. Thomas, Craig S. Nu
  Cell Metabolism.2020; 32(5): 736.     CrossRef
• Aberrant Sialylation in a Patient with a HNF1α Variant and Liver Adenomatosis
  Luisa Sturiale, Marie-Cécile Nassogne, Angelo Palmigiano, Angela Messina, Immacolata Speciale, Rosangela Artuso, Sabrina Rita Giglio, Gaetano Bertino, Nicole Revencu, Xavier Stephénne, Cristina De Castro, Gert Matthijs, Rita Barone, Jaak Jaeken, Domenico
  SSRN Electronic Journal .2020;[Epub]     CrossRef
• Pathophysiology of diabetes: An overview
  Mujeeb Z Banday, Aga S Sameer, Saniya Nissar
  Avicenna Journal of Medicine.2020; 10(04): 174.     CrossRef
• Genetic characterization of suspected MODY patients in Tunisia by targeted next-generation sequencing
  Hamza Dallali, Serena Pezzilli, Meriem Hechmi, Om Kalthoum Sallem, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Mariem Chargui, Mariem Gharbi, Luana Mercuri, Federica Alberico, Tommaso Mazza, Afaf Bahlous, Melika Ben Ahmed, Henda Jamoussi, Abdelmajid Abid,
  Acta Diabetologica.2019; 56(5): 515.     CrossRef
• MODY-Diabetes
  Sabina Baumgartner-Parzer
  Journal für Klinische Endokrinologie und Stoffwechsel.2019; 12(4): 165.     CrossRef
• Identification of a novel mutation site in maturity‑onset diabetes of the young in a Chinese family by whole‑exome sequencing
  Han Yu, Jingjin Liu, Xiaofei Li, Fang Miao, Yanlan Yang
  Molecular Medicine Reports.2019;[Epub]     CrossRef
• How can maturity-onset diabetes of the young be identified among more common diabetes subtypes?
  Jana Urbanova, Ludmila Brunerova, Jan Broz
  Wiener klinische Wochenschrift.2019; 131(17-18): 435.     CrossRef
• Using Clinical Indices to Distinguish MODY2 (GCK Mutation) and MODY3 (HNF1A Mutation) from Type 1 Diabetes in a Young Chinese Population
  Junling Fu, Tong Wang, Jieying Liu, Xiaojing Wang, Qian Zhang, Ming Li, Xinhua Xiao
  Diabetes Therapy.2019; 10(4): 1381.     CrossRef
• First Report of Diabetes Phenotype due to a Loss-of-Function ABCC8 Mutation Previously Known to Cause Congenital Hyperinsulinism
  Theocharis Koufakis, Amalia Sertedaki, Elizabeth-Barbara Tatsi, Christina-Maria Trakatelli, Spyridon N. Karras, Eleni Manthou, Christina Kanaka-Gantenbein, Kalliopi Kotsa
  Case Reports in Genetics.2019; 2019: 1.     CrossRef
• Birthweight correlates with later metabolic abnormalities in Chinese patients with maturity-onset diabetes of the young type 2
  Junling Fu, Tong Wang, Jieying Liu, Xiaojing Wang, Ming Li, Xinhua Xiao
  Endocrine.2019; 65(1): 53.     CrossRef
• Molecular and cellular regulation of human glucokinase
  Shawn M. Sternisha, Brian G. Miller
  Archives of Biochemistry and Biophysics.2019; 663: 199.     CrossRef
• Genetic studies of multifactorial diseases in the concept of personalized medicine
  N. N. Belushkina, A. S. Chemezov, M. A. Paltsev
  Profilakticheskaya meditsina.2019; 22(3): 26.     CrossRef
• Epigenome-wide association study in peripheral white blood cells involving insulin resistance
  Ana Arpón, Fermín I. Milagro, Omar Ramos-Lopez, M. Luisa Mansego, José Luis Santos, José-Ignacio Riezu-Boj, J. Alfredo Martínez
  Scientific Reports.2019;[Epub]     CrossRef
• Maturity Onset Diabetes of the Young: A Rare Monogenic Form of Diabetes
  Kallarackal M
  International Journal of Clinical Endocrinology and Metabolism.2019; : 006.     CrossRef
• Hidden MODY—Looking for a Needle in a Haystack
  Jana Urbanová, Ludmila Brunerová, Jan Brož
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Fifteen-minute consultation: Monogenic forms of diabetes with onset after age 6 months
  Emma M Dyer, Rakesh Amin
  Archives of disease in childhood - Education & practice edition.2018; 103(2): 58.     CrossRef
• Aspectos clínicos y diagnósticos de la diabetes infantil
  M. Louvigné, A. Decrequy, A. Donzeau, N. Bouhours-Nouet, R. Coutant
  EMC - Pediatría.2018; 53(1): 1.     CrossRef
• Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives
  Parveena Firdous, Kamran Nissar, Sajad Ali, Bashir Ahmad Ganai, Uzma Shabir, Toyeeba Hassan, Shariq Rashid Masoodi
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• Applications of mesoporous silica in biosensing and controlled release of insulin
  Maria Sönmez, Denisa Ficai, Anton Ficai, Laurentia Alexandrescu, Mihai Georgescu, Roxana Trusca, Dana Gurau, Mihail Aurel Titu, Ecaterina Andronescu
  International Journal of Pharmaceutics.2018; 549(1-2): 179.     CrossRef
• Novel deletion mutation in the glucokinase gene from a Korean man with GCK-MODY phenotype and situs inversus
  Yun Kyung Cho, Eun-Hee Cho, Hoon Sung Choi, Sang-Wook Kim
  Diabetes Research and Clinical Practice.2018; 143: 263.     CrossRef
• Maturity Onset Diabetes of the Young (MODY) in Tunisia: Low frequencies of GCK and HNF1A mutations
  S. Ben Khelifa, R. Martinez, A. Dandana, I. Khochtali, S. Ferchichi, L. Castaño
  Gene.2018; 651: 44.     CrossRef
• Pregnancy Complicated by Maternal MODY 3 and Paternal MODY 2 Diabetes and Subsequent Rapidly Falling Insulin Requirement
  Anastasia Mikuscheva, Adel Mekhail, Benjamin J. Wheeler
  Case Reports in Obstetrics and Gynecology.2018; 2018: 1.     CrossRef
• Mechanistic Origins of Enzyme Activation in Human Glucokinase Variants Associated with Congenital Hyperinsulinism
  Shawn M. Sternisha, Peilu Liu, Alan G. Marshall, Brian G. Miller
  Biochemistry.2018; 57(10): 1632.     CrossRef
• Genetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY)
  Xiuzhen Li, Tzer Hwu Ting, Huiying Sheng, Cui Li Liang, Yongxian Shao, Minyan Jiang, Aijing Xu, Yunting Lin, Li Liu
  BMC Pediatrics.2018;[Epub]     CrossRef
• Pathway-induced allelic spectra of diseases in the presence of strong genetic effects
  George Kanoungi, Michael Nothnagel
  Human Genetics.2018; 137(3): 215.     CrossRef
• Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing
  Eun-Hee Cho, Jae Woong Min, Sun Shim Choi, Hoon Sung Choi, Sang-Wook Kim
  Endocrinology and Metabolism.2017; 32(2): 296.     CrossRef
• The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes
  J.V. Sagen, L. Bjørkhaug, B.I. Haukanes, L. Grevle, J. Molnes, B.G. Nedrebø, O. Søvik, P.R. Njølstad, S. Johansson, A. Molven
  Diabetes Research and Clinical Practice.2017; 133: 142.     CrossRef
• Variants in MODY genes associated with maternal lipids profiles in second trimester of pregnancy
  Xiaojing Wang, Wei Li, Liangkun Ma, Fan Ping, Juntao Liu, Xueyan Wu, Jiangfeng Mao, Xi Wang, Min Nie
  The Journal of Gene Medicine.2017; 19(6-7): e2962.     CrossRef
• Genotype-Phenotype Correlation in a MODY 2 Family: An Under-Diagnosed Disease
  Maria Chiara Fabiano, Antonella Verrienti, Antonella Carbone, Marialuisa Sponziello, Pasquale Bellitti, Rocco Bruno
  Journal of Diabetes Mellitus.2016; 06(04): 263.     CrossRef
• Revisiting the Polygenic Additive Liability Model through the Example of Diabetes Mellitus
  Emmanuelle Génin, Françoise Clerget-Darpoux
  Human Heredity.2015; 80(4): 171.     CrossRef