Diabetes & Metabolism Journal

2015

Original Articles

FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women: Do Kyeong Song, Hyejin Lee, Jee-Young Oh, Young Sun Hong, Yeon-Ah Sung; Diabetes Metab J. 2014;38(4):302-310. Published online August 20, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.4.302

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Background

The fat mass and obesity-associated (FTO) gene is associated with obesity and type 2 diabetes mellitus. Obesity and insulin resistance are also common features of polycystic ovary syndrome (PCOS). Therefore, the FTO gene might be a candidate gene for PCOS susceptibility. The aim of the present study was to evaluate the effects of FTO gene variants on PCOS susceptibility and metabolic and reproductive hormonal parameters.

Methods

We recruited 432 women with PCOS (24±5 years) and 927 healthy women with regular menstrual cycles (27±5 years) and performed a case-control association study. We genotyped the single nucleotide polymorphisms rs1421085, rs17817449, and rs8050136 in the FTO gene and collected metabolic and hormonal measurements.

Results

Logistic regression revealed that the G/G genotype (rs1421085, 1.6%), the C/C genotype (rs17817449, 1.6%), and the A/A genotype (rs8050136, 1.6%) were strongly associated with an increased risk of PCOS (odds ratio, 2.551 to 2.559; all P<0.05). The strengths of these associations were attenuated after adjusting for age and BMI. The women with these genotypes were more obese and exhibited higher free androgen indices (P<0.05) and higher free testosterone levels (P=0.053 to 0.063) compared to the other genotypes. However the significant differences disappeared after adjusting for body mass index (BMI). When we analyzed the women with PCOS and the control groups separately, there were no significant differences in the metabolic and reproductive hormonal parameters according to the FTO gene variants.

Conclusion

The rs1421085, rs17817449, and rs8050136 variants of the FTO gene were associated with PCOS susceptibility and hyperandrogenemia in young Korean women. These associations may be mediated through an effect of BMI.

Citations

Citations to this article as recorded by

Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
Prakash Patil, Neevan D'Souza, Sudeep D. Ghate, Lakshmi Nagendra, Harish B. Girijashankar
Journal of Health and Allied Sciences NU.2023; 13(03): 380. CrossRef
Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS
Wassim Y. Almawi, Rita Nemr, Tomiris Atazhanova, Zainab H. Malalla, Sameh Sarray, Fekria E. Mustafa, Naeema A. Mahmood
Reproductive Sciences.2023; 30(7): 2166. CrossRef
FTO: a critical role in obesity and obesity-related diseases
Dan Yin, Yiyang Li, Xingyue Liao, Dewei Tian, Yunsi Xu, Cuilan Zhou, Jun Liu, Suyun Li, Jing Zhou, Yulin Nie, Hongqing Liao, Cuiying Peng
British Journal of Nutrition.2023; 130(10): 1657. CrossRef
Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India
Hiral Chaudhary, Jalpa Patel, Nayan K. Jain, Sonal Panchal, Naresh Laddha, Rushikesh Joshi
BMC Medical Genomics.2023;[Epub] CrossRef
ASSOCIATION BETWEEN FAT MASS AND OBESITY ASSOCIATED (FTO) RS17817449 GENE POLYMORPHISM WITH INSULIN RESISTANCE AND OBESITY IN THE PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Mahbobeh Moayeri, Masoumeh Nezhadali, Mahnaz Mohamadi
Studies in Medical Sciences.2023; 33(12): 868. CrossRef
Association of FTO gene variants rs9939609 and rs1421085 with polycystic ovary syndrome
Alaa A. Alnafjan, Afrah F. Alkhuriji, Hussah M. Alobaid, Zainb A. Babay, Mahmoud I. Khalil
Egyptian Journal of Medical Human Genetics.2022;[Epub] CrossRef
Association of FTO gene variant rs9939609 with hyperandrogenemia and fasting glucose levels in South Indian women with polycystic ovarian syndrome
Zeinab Naghshband, Suttur S. Malini
Egyptian Journal of Medical Human Genetics.2022;[Epub] CrossRef
Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome
Giorgia Scarfò, Simona Daniele, Jonathan Fusi, Marco Gesi, Claudia Martini, Ferdinando Franzoni, Vito Cela, Paolo Giovanni Artini
Biomedicines.2022; 10(6): 1305. CrossRef
Fat mass and Obesity Associated (FTO) gene and polycystic ovary syndrome: Insight into pathogenesis and association with insulin resistance
Sadaf Parveen, Saba Khan, Haseeb Ahsan, Priyanka Thapa Manger, Bhavana Gupta, Roshan Alam
Human Nutrition & Metabolism.2022; 30: 200174. CrossRef
Effect of green cardamom on the expression of genes implicated in obesity and diabetes among obese women with polycystic ovary syndrome: a double blind randomized controlled trial
Sahar Cheshmeh, Negin Elahi, Maysa Ghayyem, Elaheh Mosaieby, Shima Moradi, Yahya Pasdar, Susan Tahmasebi, Mehdi Moradinazar
Genes & Nutrition.2022;[Epub] CrossRef
In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study
Umayal Branavan, Sulochana Wijesundera, Vishvanath Chandrasekaran, Carukshi Arambepola, Chandrika Wijeyaratne
BMC Medical Genetics.2020;[Epub] CrossRef
Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study
Yalin Zhao, Yuping Xu, Xiaomeng Wang, Lin Xu, Jianhua Chen, Chengwen Gao, Chuanhong Wu, Dun Pan, Qian Zhang, Juan Zhou, Ruirui Chen, Zhuo Wang, Han Zhao, Li You, Yunxia Cao, Zhiqiang Li, Yongyong Shi
The Journal of Clinical Endocrinology & Metabolism.2020; 105(6): 1778. CrossRef
Polikistik Over Sendromu ve Obezite: FTO ve MC4R Gen Polimorfizmlerinin Rolü
Ayçıl ÖZTURAN ŞİRİN, Yasemin AKDEVELİOĞLU
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi.2020; 4(3): 275. CrossRef
Vitamin D receptor and binding protein polymorphisms in women with polycystic ovary syndrome: a case control study
Do Kyeong Song, Hyejin Lee, Young Sun Hong, Yeon-Ah Sung
BMC Endocrine Disorders.2019;[Epub] CrossRef
Phenotype and genotype of polycystic ovary syndrome in Asia: Ethnic differences
Jin Ju Kim, Young Min Choi
Journal of Obstetrics and Gynaecology Research.2019; 45(12): 2330. CrossRef
Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis
Ritu Deswal, Arun Yadav, Amita Suneja Dang
Systems Biology in Reproductive Medicine.2018; 64(1): 12. CrossRef
Association between FTO gene polymorphisms and type 2 diabetes mellitus, serum levels of apelin and androgen hormones among Iranian obese women
Farzaneh Ghafarian-Alipour, Shayan Ziaee, Mohamad Reza Ashoori, Mir Saeid Zakeri, Mohammad Ali Boroumand, Naser Aghamohammadzadeh, Maryam Abbasi-Majdi, Fatemeh Shool, Navid Sarakhs Asbaghi, Abolghasem Mohammadi, Nosratollah Zarghami
Gene.2018; 641: 361. CrossRef
The role of FTO variants in the susceptibility of polycystic ovary syndrome and in vitro fertilization outcomes in Chinese women
Ai Ling Liu, Hong Qing Liao, Jing Zhou, Yu Lin Nie, Cui Lan Zhou, Zhi Liang Li, Zi Fen Guo, Dong Xiu He, Yun Hua Zhu, Cui Ying Peng
Gynecological Endocrinology.2018; 34(8): 719. CrossRef
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
Joel Eriksson, Robin Haring, Niels Grarup, Liesbeth Vandenput, Henri Wallaschofski, Erik Lorentzen, Torben Hansen, Dan Mellström, Oluf Pedersen, Matthias Nauck, Mattias Lorentzon, Lise Lotte Nystrup Husemoen, Henry Völzke, Magnus Karlsson, Sebastian E. Ba
PLOS ONE.2017; 12(4): e0176277. CrossRef
Post-transcriptional gene regulation by mRNA modifications
Boxuan Simen Zhao, Ian A. Roundtree, Chuan He
Nature Reviews Molecular Cell Biology.2017; 18(1): 31. CrossRef
The Role of Serum MicroRNA-6767-5p as a Biomarker for the Diagnosis of Polycystic Ovary Syndrome
Do Kyeong Song, Yeon-Ah Sung, Hyejin Lee, Wan-Xi Yang
PLOS ONE.2016; 11(9): e0163756. CrossRef
Haplotyping strategy highlights the specificity of FTO gene association with polycystic ovary syndrome in Tunisian women population
Assila Ben Salem, Redha Attaoua, Nabil Mtiraoui, Sawssen Meddeb, Olfa Kacem, Mounir Ajina, Moncef Souissi, Patrick Poucheret, Christophe Normand, Touhami Mahjoub, Florin Grigorescu
Gene.2015; 565(2): 166. CrossRef
FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil
Ramon B. Ramos, Poli Mara Spritzer
Gene.2015; 560(1): 25. CrossRef
Interaction between common variants of FTO and MC4R is associated with risk of PCOS
Huiqin Yuan, Guoping Zhu, Fang Wang, Xiang Wang, Huihui Guo, Mo Shen
Reproductive Biology and Endocrinology.2015;[Epub] CrossRef

Assessment of Diabetic Polyneuropathy and Autonomic Neuropathy Using Current Perception Threshold in Korean Patients with Diabetes Mellitus: Bo Kyung Koo, Jung Hun Ohn, Soo-Heon Kwak, Min Kyong Moon; Diabetes Metab J. 2014;38(4):285-293. Published online August 20, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.4.285

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Background

The current perception threshold (CPT) could be quantified by stimulating Aβ and C fibers at 2,000 and 5 Hz, respectively. C fibers play a role in the autonomic nervous system and are involved in temperature and pain sensation. We evaluated the usefulness of CPT for diagnosing distal polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) in diabetic patients.

Methods

The CPT was measured in the index finger (C7 level) and in the third toe (L5 level) in diabetic patients aged 30 to 69 years. We assessed DPN according to the neuropathy total symptom score-6 (NTSS-6) and 10-g monofilament pressure sensation. Subjects with a NTSS-6 >6 or with abnormal 10-g monofilament sensation were defined to have DPN. CAN was evaluated by spectral analysis of heart rate variability and by Ewing's traditional tests.

Results

The subjects with DPN had significantly higher CPT at all of the frequencies than the subjects without DPN (P<0.05). Abnormal 10-g monofilament sensation and NTSS-6 >6 could be most precisely predicted by CPT at 2,000 and 5 Hz, respectively. However, only 6.5% and 19.6% of subjects with DPN had an abnormal CPT at 2,000 Hz at the C7 and L5 levels. Although CPT at 5 Hz showed a negative correlation with the power of low and high frequency in the spectral analysis (P<0.05), only 16.7% of subjects with CAN exhibited an abnormal CPT at the same frequency.

Conclusion

Although the CPT is significantly associated with neuropathic symptoms or signs corresponding to the nerve fiber stimulated, it provides little additional information compared with conventional evaluations.

Citations

Citations to this article as recorded by

New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine
Heng Yang, Gordon Sloan, Yingchun Ye, Shuo Wang, Bihan Duan, Solomon Tesfaye, Ling Gao
Frontiers in Endocrinology.2020;[Epub] CrossRef
Patterns of Nerve Conduction Abnormalities in Patients with Type 2 Diabetes Mellitus According to the Clinical Phenotype Determined by the Current Perception Threshold
Joong Hyun Park, Jong Chul Won
Diabetes & Metabolism Journal.2018; 42(6): 519. CrossRef
Association between Pain Sensitivity, Central Sensitization, and Functional Disability in Adolescents With Joint Hypermobility
Elizabeth A. Bettini, Ki Moore, Yunfei Wang, Pamela S. Hinds, Julia C. Finkel
Journal of Pediatric Nursing.2018; 42: 34. CrossRef
The impact of neuropathic pain and other comorbidities on the quality of life in patients with diabetes
Vesna Dermanovic Dobrota, Pero Hrabac, Dinko Skegro, Ranko Smiljanic, Savko Dobrota, Ingrid Prkacin, Neva Brkljacic, Kristijan Peros, Martina Tomic, Vesna Lukinovic-Skudar, Vanja Basic Kes
Health and Quality of Life Outcomes.2014;[Epub] CrossRef

Statin Discontinuation after Achieving a Target Low Density Lipoprotein Cholesterol Level in Type 2 Diabetic Patients without Cardiovascular Disease: A Randomized Controlled Study: Seung-Hwan Lee, Hyuk-Sang Kwon, Yong-Moon Park, Seung-Hyun Ko, Yoon-Hee Choi, Kun-Ho Yoon, Yu-Bae Ahn; Diabetes Metab J. 2014;38(1):64-73. Published online February 19, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.1.64

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47 Download
16 Web of Science
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Abstract PDF PubReader

Background

This study investigated the rate of relapse of dyslipidemia and the factors which could predict relapse following a short-term statin discontinuation after achieving a target low density lipoprotein cholesterol (LDL-C) level in type 2 diabetic patients without cardiovascular disease (CVD).

Methods

Ninety-nine subjects on rosuvastatin treatment and whose LDL-C level was lower than 100 mg/dL were randomly assigned to discontinue or maintain statin treatment at a 2:1 ratio. The subjects were followed-up after 10 weeks. A relapse of dyslipidemia was defined as a reascent of LDL-C level to greater than 100 mg/dL.

Results

The statin discontinuation group had a significant rate of relapse compared to the maintenance group (79% vs. 3%, respectively). Pretreatment and baseline lipid levels, their ratios, and hemoglobin A1c level were significantly different between the relapse and nonrelapse groups. The pretreatment and baseline lipid profiles and their ratios were independently associated with relapse. The pretreatment LDL-C level was the most useful parameter for predicting a relapse, with a cutoff of 123 mg/dL. During the follow-up period, no CVD event was noted.

Conclusion

The relapse rate of dyslipidemia was high when statins were discontinued in type 2 diabetic patients without CVD. Statin discontinuation should be considered carefully based on the pretreatment lipid profiles of patients.

Citations

Citations to this article as recorded by

Cardiovascular Outcomes and Mortality Associated With Discontinuing Statins in Older Patients Receiving Polypharmacy
Federico Rea, Annalisa Biffi, Raffaella Ronco, Matteo Franchi, Simona Cammarota, Anna Citarella, Valeria Conti, Amelia Filippelli, Carmine Sellitto, Giovanni Corrao
JAMA Network Open.2021; 4(6): e2113186. CrossRef
Visit-to-visit variability of lipid measurements and the risk of myocardial infarction and all-cause mortality: A prospective cohort study
Xiaoxue Liu, Shouling Wu, Qiaofeng Song, Xizhu Wang
Atherosclerosis.2020; 312: 110. CrossRef
2018 Guidelines for the management of dyslipidemia
Eun-Jung Rhee, Hyeon Chang Kim, Jae Hyeon Kim, Eun Young Lee, Byung Jin Kim, Eun Mi Kim, YoonJu Song, Jeong Hyun Lim, Hae Jin Kim, Seonghoon Choi, Min Kyong Moon, Jin Oh Na, Kwang-Yeol Park, Mi Sun Oh, Sang Youb Han, Junghyun Noh, Kyung Hee Yi, Sang-Hak L
The Korean Journal of Internal Medicine.2019; 34(4): 723. CrossRef
2018 Guidelines for the Management of Dyslipidemia in Korea
Eun-Jung Rhee, Hyeon Chang Kim, Jae Hyeon Kim, Eun Young Lee, Byung Jin Kim, Eun Mi Kim, YoonJu Song, Jeong Hyun Lim, Hae Jin Kim, Seonghoon Choi, Min Kyong Moon, Jin Oh Na, Kwang-Yeol Park, Mi Sun Oh, Sang Youb Han, Junghyun Noh, Kyung Hee Yi, Sang-Hak L
Journal of Lipid and Atherosclerosis.2019; 8(2): 78. CrossRef
Patterns of statin use and long‐term adherence and persistence among older adults with diabetes
Richard Ofori‐Asenso, Jenni Ilomäki, Mark Tacey, Ella Zomer, Andrea J. Curtis, J. Simon Bell, Sophia Zoungas, Danny Liew
Journal of Diabetes.2018; 10(9): 699. CrossRef
Effect of visit-to-visit LDL-, HDL-, and non-HDL-cholesterol variability on mortality and cardiovascular outcomes after percutaneous coronary intervention
Eun Young Lee, Yeoree Yang, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Wook Sung Chung, Seung-Hwan Lee, Kiyuk Chang
Atherosclerosis.2018; 279: 1. CrossRef
Change in ALT levels after administration of HMG‐CoA reductase inhibitors to subjects with pretreatment levels three times the upper normal limit in clinical practice
Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun‐Ho Yoon, Hun‐Sung Kim
Cardiovascular Therapeutics.2018;[Epub] CrossRef
Orthodox religious fasting as a medical nutrition therapy for dyslipidemia: where do we stand and how far can we go?
Theocharis Koufakis, Spyridon N Karras, Pantelis Zebekakis, Kalliopi Kotsa
European Journal of Clinical Nutrition.2018; 72(4): 474. CrossRef
Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization
Jingyun Choi, Yejin Kim, Hun-Sung Kim, In Young Choi, Hwanjo Yu, Katriina Aalto-Setala
PLOS ONE.2018; 13(6): e0197518. CrossRef
Impact of educational outreach intervention on enhancing health care providers' knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus
Mohamed Hassan Elnaem, Mohamad Haniki Nik Mohamed, Hasniza Zaman Huri, Shah M Azarisman
Journal of Evaluation in Clinical Practice.2018; 24(3): 521. CrossRef
Use of Moderate‐Intensity Statins for Low‐Density Lipoprotein Cholesterol Level above 190 mg/dL at Baseline in Koreans
Hun‐Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung‐Hwan Lee, Jae Hyoung Cho, In‐Young Choi, Kun‐Ho Yoon, Ju Han Kim
Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 272. CrossRef
Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study
Mee Kyoung Kim, Kyungdo Han, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
European Heart Journal.2017; 38(48): 3560. CrossRef
Analysis and comparison of the cost-effectiveness of statins according to the baseline low-density lipoprotein cholesterol level in Korea
Y. J. Jeong, H. Kim, S. J. Baik, T. M. Kim, S. J. Yang, S.-H. Lee, J.-H. Cho, H. Lee, H. W. Yim, I. Y. Choi, K.-H. Yoon, H.-S. Kim
Journal of Clinical Pharmacy and Therapeutics.2017; 42(3): 292. CrossRef
The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156. CrossRef
Statin for the Primary Prevention of Cardiovascular Disease in Patients with Diabetes Mellitus
Bo Kyung Koo
Diabetes & Metabolism Journal.2014; 38(1): 32. CrossRef

Assessment of the Association between Mean Hemoglobin A1c Levels for 5 Years and Coronary Artery Disease by Coronary Angiography in Nondiabetic Patients: Jae-Joon Kim, Ji-Hoon Kang, Ja-Jun Goo, Kyoung-Nyoun Kim, Ja-Young Lee, Mi-kyung Kim, Tae Ik Kim; Diabetes Metab J. 2014;38(1):58-63. Published online February 19, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.1.58

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Background

The effects of glucose on cardiovascular events or mortality in nondiabetic patients has been recently reported. However, since atherosclerosis can be formed over a long period of time, it is necessary to devote several years to unveil the relationship between the two factors. Here, we attempted to find out the relationship between the mean hemoglobin A1c (HbA1c) level and HbA1c variability for 5 years and coronary artery disease (CAD) by using coronary angiography (CAG) to assess nondiabetic patients.

Methods

We reviewed patients who performed CAG who were followed up for at least 5 years after the initial diagnosis. The fasting blood test was performed annually for glucose and HbA1c level. CAD was defined as more than 50% of luminal narrowing. The severity of CAD was divided into two groups depending on whether no vessels were involved or one more vessel were involved (CAD(-) or CAD(+), respectively).

Results

The patients in CAD(+) group had higher mean HbA1c level for 5 years than CAD(-) group (5.71±0.40 vs. 5.86±0.68; P=0.04). Mean HbA1c was a significant predictor for CAD in multiple regression (odds ratio, 2.224; P=0.028). The percentage of patients with CAD was significantly higher in patients with >6.2% of mean HbA1c levels compared to patients with <6.2% of mean HbA1c levels (P<0.019).

Conclusion

When the mean HbA1c levels were above 6.2%, the risk of CAD was higher. Also this study shows that HbA1c level can be one of the predictors for CAD even if the patients do not have diabetes.

Citations

Citations to this article as recorded by

Impact of a comprehensive cardiac rehabilitation programme versus coronary revascularisation in patients with stable angina pectoris: study protocol for the PRO-FIT randomised controlled trial
Joyce M. Heutinck, Iris A. De Koning, Tom Vromen, Robert-Jan M. Van Geuns, Dick H.J. Thijssen, Hareld M.C. Kemps, Eddy M. Adang, Johanna M. Geleijnse, Pieter van Gorp, Arnoud W. J. van ‘t Hof, Veronica R. Janssen, Harald T. Jorstad, Roderik A. Kraaijenhag
BMC Cardiovascular Disorders.2023;[Epub] CrossRef
Evaluation of HbA1c as a prognostic biomarker of cardiovascular events and mortality in nondiabetic patients: Methodological considerations
Denis Monneret
Atherosclerosis.2015; 242(1): 19. CrossRef

Plasma Glucose Regulation and Mortality in Korea: A Pooled Analysis of Three Community-Based Cohort Studies: Nan Hee Kim, Dong-Jun Kim, Seok Won Park, Jee-Young Oh, Joong-Yeol Park, Chol Shin, Hong Kyu Lee, Yongsoo Park; Diabetes Metab J. 2014;38(1):44-50. Published online February 19, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.1.44

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Background

Although diabetes is a well-known risk factor for death, its impact on cancer death is not clearly understood. Furthermore, it remains controversial whether impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are associated with increased risk of mortality. We investigated the impact of diabetes or glucose tolerance categories on all cause and cause-specific mortality.

Methods

Mortality analysis was conducted in three population-based cohort studies of 3,801 participants, divided according to fasting plasma glucose (FPG) (normal; stage 1 IFG [5.6≤FPG<6.1 mmol/L]; stage 2 IFG [6.1≤FPG<7.0 mmol/L]; diabetes mellitus [DM]-FPG); or 2-hour glucose after 75 g glucose loading (2hPG) (normal; IGT; DM-2hPG), or a combination of FPG and 2hPG criteria.

Results

During a median follow-up of 11.0 years, 474 subjects died from all causes. Hazard ratios (HRs) for all cause death were higher in those with diabetes as defined by either FPG or 2hPG criteria than their normal counterparts (HR, 2.2, 95% confidence interval [CI], 1.6 to 2.9 for DM-FPG; HR, 2.0, 95% CI, 1.5 to 2.7 for DM-2hPG). Similarly, diabetes defined by either FPG or 2hPG was associated with cancer death (HR, 2.9, 95% CI, 1.7 to 5.0; and HR, 2.1, 95% CI, 1.2 to 3.9, respectively). Although neither IFG nor IGT conferred higher risk for death, when combining stage 2 IFG and/or IGT, the risk of all cause death was higher than in subjects with normal glucose regulation (HR, 1.3; 95% CI, 1.0 to 1.6).

Conclusion

Diabetes is associated with higher risk of death from all causes and cancer. In subjects without diabetes, stage 2 IFG and/or IGT confers increased risk for mortality.

Citations

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Abnormal Fasting Glucose Increases Risk of Unrecognized Myocardial Infarctions in an Elderly Cohort
Richard Brandon Stacey, Janice Zgibor, Paul E. Leaverton, Douglas D. Schocken, Jennifer A. Peregoy, Mary F. Lyles, Alain G. Bertoni, Gregory L. Burke
Journal of the American Geriatrics Society.2019; 67(1): 43. CrossRef
Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke
Nam Hoon Kim, Tae Yeon Kwon, Sungwook Yu, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yousung Park, Sin Gon Kim
Stroke.2017; 48(4): 840. CrossRef
β-Cell Function and Insulin Sensitivity in Normal Glucose-Tolerant Subjects Stratified by 1-Hour Plasma Glucose Values
Miranda M. Priya, Anandakumar Amutha, T.A. Pramodkumar, Harish Ranjani, Saravanan Jebarani, Kuppan Gokulakrishnan, Rajendra Pradeepa, Ranjit Unnikrishnan, Ranjit Mohan Anjana, Viswanathan Mohan
Diabetes Technology & Therapeutics.2016; 18(1): 29. CrossRef
Effect of Socio-Economic Status on the Prevalence of Diabetes
Yu Jeong Kim, Ja Young Jeon, Seung Jin Han, Hae Jin Kim, Kwan Woo Lee, Dae Jung Kim
Yonsei Medical Journal.2015; 56(3): 641. CrossRef
The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
Chang Hee Jung, Gi Hyeon Seo, Sunghwan Suh, Ji Cheol Bae, Mee Kyoung Kim, You-Cheol Hwang, Jae Hyeon Kim, Byung-Wan Lee, Xian Wu Cheng
PLOS ONE.2015; 10(6): e0128627. CrossRef

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